{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T04:53:29Z","timestamp":1793163209358,"version":"4.5.0"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"23","license":[{"start":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T00:00:00Z","timestamp":1642464000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T00:00:00Z","timestamp":1642464000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1007\/s11356-021-18218-3","type":"journal-article","created":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T21:07:31Z","timestamp":1642453651000},"page":"34594-34606","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":123,"title":["Exposure to microplastics leads to a defective ovarian function and change in cytoskeleton protein expression in rat"],"prefix":"10.1007","volume":"29","author":[{"given":"Asma","family":"Haddadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaouthar","family":"Kessabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sana","family":"Boughammoura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariem Ben","family":"Rhouma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rania","family":"Mlouka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Banni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4025-8765","authenticated-orcid":false,"given":"Imed","family":"Messaoudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,18]]},"reference":[{"issue":"4","key":"18218_CR1","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1096\/fj.15-280313","volume":"30","author":"A Abedini","year":"2016","unstructured":"Abedini A, Zamberlam G, Lapointe E, Tourigny C, Boyer A, Paquet M, Boerboom D (2016) WNT5a is required for normal ovarian follicle development and antagonizes gonadotropin responsiveness in granulosa cells by suppressing canonical WNT signaling. Faseb J 30(4):1534\u20131547. https:\/\/doi.org\/10.1096\/fj.15-280313","journal-title":"Faseb J"},{"key":"18218_CR2","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/s0076-6879(84)05016-3","volume":"105","author":"H Aebi","year":"1984","unstructured":"Aebi H (1984) Catalase in vitro. Methods Enzymol 105:121\u2013126. https:\/\/doi.org\/10.1016\/s0076-6879(84)05016-3","journal-title":"Methods Enzymol"},{"key":"18218_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2020.114158","volume":"261","author":"F Amereh","year":"2020","unstructured":"Amereh F, Babaei M, Eslami A, Fazelipour S, Rafiee M (2020) The emerging risk of exposure to nano(micro)plastics on endocrine disturbance and reproductive toxicity: from a hypothetical scenario to a global public health challenge. Environ Pollut 261:114158. https:\/\/doi.org\/10.1016\/j.envpol.2020.114158","journal-title":"Environ Pollut"},{"key":"18218_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2020.152665","volume":"449","author":"R An","year":"2021","unstructured":"An R, Wang X, Yang L, Zhang J, Wang N, Xu F, Zhang L (2021) Polystyrene microplastics cause granulosa cells apoptosis and fibrosis in ovary through oxidative stress in rats. Toxicology 449:152665. https:\/\/doi.org\/10.1016\/j.tox.2020.152665","journal-title":"Toxicology"},{"issue":"5","key":"18218_CR5","doi-asserted-by":"publisher","first-page":"e18904","DOI":"10.1371\/journal.pone.0018904","volume":"6","author":"M Banni","year":"2011","unstructured":"Banni M, Negri A, Mignone F, Boussetta H, Viarengo A, Dondero F (2011) Gene expression rhythms in the mussel Mytilus galloprovincialis (Lam.) across an annual cycle. PLoS One 6(5):e18904. https:\/\/doi.org\/10.1371\/journal.pone.0018904","journal-title":"PLoS One"},{"issue":"3","key":"18218_CR6","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.cbpc.2008.09.017","volume":"149","author":"M Banni","year":"2009","unstructured":"Banni M, Negri A, Rebelo M, Rapallo F, Boussetta H, Viarengo A, Dondero F (2009) Expression analysis of the molluscan p53 protein family mRNA in mussels (Mytilus spp.) exposed to organic contaminants. Comp Biochem Physiol C ToxicolPharmacol 149(3):414\u2013418. https:\/\/doi.org\/10.1016\/j.cbpc.2008.09.017","journal-title":"Comp Biochem Physiol C ToxicolPharmacol"},{"issue":"13","key":"18218_CR7","doi-asserted-by":"publisher","first-page":"5026","DOI":"10.1021\/es800249a","volume":"42","author":"MA Browne","year":"2008","unstructured":"Browne MA, Dissanayake A, Galloway TS, Lowe DM, Thompson RC (2008) Ingested microscopic plastic translocates to the circulatory system of the mussel, Mytilus edulis (L). Environ Sci Technol 42(13):5026\u20135031. https:\/\/doi.org\/10.1021\/es800249a","journal-title":"Environ Sci Technol"},{"key":"18218_CR8","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1016\/j.envpol.2017.10.015","volume":"233","author":"S Bruck","year":"2018","unstructured":"Bruck S, Ford AT (2018) Chronic ingestion of polystyrene microparticles in low doses has no effect on food consumption and growth to the intertidal amphipod Echinogammarus marinus. Environ Pollut 233:1125\u20131130. https:\/\/doi.org\/10.1016\/j.envpol.2017.10.015","journal-title":"Environ Pollut"},{"key":"18218_CR9","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.envint.2018.03.007","volume":"115","author":"M Carbery","year":"2018","unstructured":"Carbery M, O\u2019Connor W, Palanisami T (2018) Trophic transfer of microplastics and mixed contaminants in the marine food web and implications for human health. Environ Int 115:400\u2013409. https:\/\/doi.org\/10.1016\/j.envint.2018.03.007","journal-title":"Environ Int"},{"key":"18218_CR10","doi-asserted-by":"publisher","first-page":"46687","DOI":"10.1038\/srep46687","volume":"7","author":"Y Deng","year":"2017","unstructured":"Deng Y, Zhang Y, Lemos B, Ren H (2017) Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure. Sci Rep 7:46687. https:\/\/doi.org\/10.1038\/srep46687","journal-title":"Sci Rep"},{"key":"18218_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2020.124644","volume":"15","author":"Y Deng","year":"2021","unstructured":"Deng Y, Yan Z, Shen R, Huang Y, Ren H, Zhang Y (2021) Enhanced reproductive toxicities induced by phthalates contaminated microplastics in male mice (Mus musculus). J Hazard Mater 15:124644. https:\/\/doi.org\/10.1016\/j.jhazmat.2020.124644","journal-title":"J Hazard Mater"},{"key":"18218_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2020.113937","volume":"259","author":"A Elizalde-Vel\u00e1zquez","year":"2020","unstructured":"Elizalde-Vel\u00e1zquez A, Carcano AM, Crago J, Green MJ, Shah SA, Ca\u00f1as-Carrell JE (2020) Translocation, trophic transfer, accumulation and depuration of polystyrene microplastics in Daphnia magna and Pimephales promelas. Environ Pollut 259:113937. https:\/\/doi.org\/10.1016\/j.envpol.2020.113937","journal-title":"Environ Pollut"},{"key":"18218_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.envpol.2013.01.046","volume":"177","author":"P Farrell","year":"2013","unstructured":"Farrell P, Nelson K (2013) Trophic level transfer of microplastic: Mytilus edulis (L.) to Carcinus maenas (L.). Environ Pollut 177:1\u20133. https:\/\/doi.org\/10.1016\/j.envpol.2013.01.046","journal-title":"Environ Pollut"},{"key":"18218_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.136567","volume":"714","author":"V Felten","year":"2020","unstructured":"Felten V, Toumi H, Masfaraud JF, Billoir E, Camara BI, F\u00e9rard JF (2020) Microplastics enhance Daphnia magna sensitivity to the pyrethroid insecticide deltamethrin: effects on life history traits. Sci Total Environ 714:136567. https:\/\/doi.org\/10.1016\/j.scitotenv.2020.136567","journal-title":"Sci Total Environ"},{"issue":"9","key":"18218_CR15","doi-asserted-by":"publisher","first-page":"2331","DOI":"10.1073\/pnas.1600715113","volume":"113","author":"TS Galloway","year":"2016","unstructured":"Galloway TS, Lewis CN (2016) Marine microplastics spell big problems for future generations. Proc Nat Acad Sci USA 113(9):2331\u20132333. https:\/\/doi.org\/10.1073\/pnas.1600715113","journal-title":"Proc Nat Acad Sci USA"},{"key":"18218_CR16","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1146\/annurev.ph.41.030179.003415","volume":"41","author":"RD Goldman","year":"1979","unstructured":"Goldman RD, Milsted A, Schloss JA, Starger J, Yerna MJ (1979) Cytoplasmic fibers in mammalian cells: cytoskeletal and contractile elements. Annu Rev Physiol 41:703\u2013722. https:\/\/doi.org\/10.1146\/annurev.ph.41.030179.003415","journal-title":"Annu Rev Physiol"},{"key":"18218_CR17","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/916212","volume":"2014","author":"S Gupta","year":"2014","unstructured":"Gupta S, Ghulmiyyah J, Sharma R, Halabi J, Agarwal A (2014) Power of proteomics in linking oxidative stress and female infertility. Biomed Res Int 2014:916212. https:\/\/doi.org\/10.1155\/2014\/916212","journal-title":"Biomed Res Int"},{"issue":"7","key":"18218_CR18","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/s0092-8674(01)00614-6","volume":"107","author":"R Habas","year":"2001","unstructured":"Habas R, Kato Y, He X (2001) Wnt\/Frizzled activation of rho regulates vertebrate gastrulation and requires a novel formin homology protein Daam1. Cell 107(7):843\u2013854. https:\/\/doi.org\/10.1016\/s0092-8674(01)00614-6","journal-title":"Cell"},{"key":"18218_CR19","doi-asserted-by":"publisher","unstructured":"Hamed M, Soliman HA, OsmanAG, Sayed AEDH(2020) Antioxidants and molecular damage in Nile Tilapia (Oreochromis niloticus) after exposure to microplastics. Environ Sci Pollut Res 1-8. https:\/\/doi.org\/10.1007\/s11356-020-07898-y","DOI":"10.1007\/s11356-020-07898-y"},{"issue":"22","key":"18218_CR20","doi-asserted-by":"publisher","first-page":"13451","DOI":"10.1021\/es501385y","volume":"48","author":"J Haemer","year":"2014","unstructured":"Haemer J, Gutow L, K\u00f6hler A, Saborowski R (2014) Fate of microplastics in the marine isopod Idotea emarginata. Environ Sci Technol 48(22):13451\u201313458. https:\/\/doi.org\/10.1021\/es501385y","journal-title":"Environ Sci Technol"},{"issue":"1","key":"18218_CR21","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/0890-6238(87)90074-8","volume":"1","author":"N Hirshfield","year":"1987","unstructured":"Hirshfield N (1987) Histological assessment of follicular development and its applicability to risk assessment. Reprod Toxicol 1(1):71\u201379. https:\/\/doi.org\/10.1016\/0890-6238(87)90074-8","journal-title":"Reprod Toxicol"},{"key":"18218_CR22","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s12989-020-00387-7","volume":"17","author":"N Hirt","year":"2020","unstructured":"Hirt N, Body-Malapel M (2020) Immunotoxicity and intestinal effects of nano- and microplastics: a review of the literature. Toxicology 17:57. https:\/\/doi.org\/10.1186\/s12989-020-00387-7","journal-title":"Toxicology"},{"key":"18218_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2021.112012","volume":"212","author":"J Hou","year":"2021","unstructured":"Hou J, Lei Z, Cui L, Hou Y, Yang L, An R, Zhang L (2021) Polystyrene microplastics lead to pyroptosis and apoptosis of ovarian granulosa cells via NLRP3\/caspase-1 signaling pathway in rats. Ecotoxicol Environ Saf 212:112012. https:\/\/doi.org\/10.1016\/j.ecoenv.2021.112012","journal-title":"Ecotoxicol Environ Saf"},{"issue":"1","key":"18218_CR24","doi-asserted-by":"publisher","first-page":"10145","DOI":"10.1038\/s41598-018-28544-1","volume":"8","author":"LL Hu","year":"2018","unstructured":"Hu LL, Zhou X, Zhang HL, Wu LL, Tang LS, Chen LL, Duan JL (2018) Exposure to podophyllotoxin inhibits oocyte meiosis by disturbing meiotic spindle formation. Sci Rep 8(1):10145. https:\/\/doi.org\/10.1038\/s41598-018-28544-1","journal-title":"Sci Rep"},{"issue":"10","key":"18218_CR25","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1016\/j.freeradbiomed.2004.02.074","volume":"36","author":"AK Jaiswal","year":"2004","unstructured":"Jaiswal AK (2004) Nrf2 signaling in coordinated activation of antioxidant gene expression. Free Radic Biol Med 36(10):1199\u20131207. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2004.02.074","journal-title":"Free Radic Biol Med"},{"key":"18218_CR26","doi-asserted-by":"publisher","first-page":"41323","DOI":"10.1038\/srep41323","volume":"7","author":"CB Jeong","year":"2017","unstructured":"Jeong CB, Kang HM, Lee MC, Kim DH, Han J, Hwang DS, Lee JS (2017) Adverse effects of microplastics and oxidative stress-induced MAPK\/Nrf2 pathway-mediated defense mechanisms in the marine copepod Paracyclopina nana. Sci Rep 7:41323. https:\/\/doi.org\/10.1038\/srep41323","journal-title":"Sci Rep"},{"issue":"16","key":"18218_CR27","doi-asserted-by":"publisher","first-page":"8849","DOI":"10.1021\/acs.est.6b01441","volume":"50","author":"CB Jeong","year":"2016","unstructured":"Jeong CB, Won EJ, Kang HM, Lee MC, Hwang DS, Hwang UK, Lee JS (2016) Microplastic size-dependent toxicity, oxidative stress induction, and p-JNK and p-p38 activation in the monogonont rotifer (Brachionus koreanus). Environ Sci Technol 50(16):8849\u20138857. https:\/\/doi.org\/10.1021\/acs.est.6b01441","journal-title":"Environ Sci Technol"},{"issue":"401","key":"18218_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2020.123430","volume":"5","author":"H Jin","year":"2021","unstructured":"Jin H, Ma T, Sha X, Liu Z, Zhou Y, Meng X, Chen Y, Han X, Ding J (2021) Polystyrene microplastics induced male reproductive toxicity in mice. J Hazard Mater 5(401):123430. https:\/\/doi.org\/10.1016\/j.jhazmat.2020.123430","journal-title":"J Hazard Mater"},{"key":"18218_CR29","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.tox.2019.04.016","volume":"421","author":"D Kalo","year":"2019","unstructured":"Kalo D, Vitorino Carvalho A, Archilla C, Duranthon V, Moroldo M, Levin Y, Roth Z (2019) Mono(2-ethylhexyl) phthalate (MEHP) induces transcriptomic alterations in oocytes and their derived blastocysts. Toxicology 421:59\u201373. https:\/\/doi.org\/10.1016\/j.tox.2019.04.016","journal-title":"Toxicology"},{"issue":"16","key":"18218_CR30","doi-asserted-by":"publisher","first-page":"6708","DOI":"10.1073\/pnas.0608946104","volume":"A104","author":"YS Kida","year":"2007","unstructured":"Kida YS, Sato T, Miyasaka KY, Suto A, Ogura T (2007) Daam1 regulates the endocytosis of EphB during the convergent extension of the zebrafish notochord. Proc Natl Acad Sci U S A104(16):6708\u20136713. https:\/\/doi.org\/10.1073\/pnas.0608946104","journal-title":"Proc Natl Acad Sci U S"},{"key":"18218_CR31","first-page":"9","volume":"32","author":"J Kruger","year":"1994","unstructured":"Kruger J (1994) The Bradford method for protein quantitation. Meth Mol Biol 32:9\u201315","journal-title":"Meth Mol Biol"},{"issue":"4","key":"18218_CR32","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25(4):402\u2013408. https:\/\/doi.org\/10.1006\/meth.2001.1262","journal-title":"Methods"},{"key":"18218_CR33","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.scitotenv.2018.03.051","volume":"631","author":"L Lu","year":"2018","unstructured":"Lu L, WanZ LT, Fu Z, Jin Y (2018a) Polystyrene microplastics induce gut microbiota dysbiosis and hepatic lipid metabolism disorder in mice. Sci Total Environ 631:449\u2013458","journal-title":"Sci Total Environ"},{"issue":"5","key":"18218_CR34","doi-asserted-by":"publisher","first-page":"2335","DOI":"10.1093\/nar\/gky001","volume":"46","author":"Y Lu","year":"2018","unstructured":"Lu Y, Li S, Cui Z, Dai X, Zhang M, Miao Y, Xiong B (2018b) The cohesion establishment factor Esco1 acetylates \u03b1-tubulin to ensure proper spindle assembly in oocyte meiosis. Nucleic Acids Res 46(5):2335\u20132346. https:\/\/doi.org\/10.1093\/nar\/gky001","journal-title":"Nucleic Acids Res"},{"issue":"7","key":"18218_CR35","doi-asserted-by":"publisher","first-page":"4054","DOI":"10.1021\/acs.est.6b00183","volume":"50","author":"Y Lu","year":"2016","unstructured":"Lu Y, Zhang Y, Deng Y, Jiang W, Zhao Y, Geng J, Ren H (2016) Uptake and accumulation of polystyrene microplastics in zebrafish (Danio rerio) and toxic effects in liver. Environ Sci Technol 50(7):4054\u20134060. https:\/\/doi.org\/10.1021\/acs.est.6b00183","journal-title":"Environ Sci Technol"},{"issue":"Pt 1","key":"18218_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2019.113122","volume":"255","author":"T Luo","year":"2019","unstructured":"Luo T, Zhang Y, Wang C, Wang X, Zhou J, Shen M, Jin Y (2019) Maternal exposure to different sizes of polystyrene microplastics during gestation causes metabolic disorders in their offspring. Environ Pollut 255(Pt 1):113122. https:\/\/doi.org\/10.1016\/j.envpol.2019.113122","journal-title":"Environ Pollut"},{"key":"18218_CR37","doi-asserted-by":"publisher","unstructured":"MagniS DT, C, Garrone G, D\u2019Amato A, Parenti CC, Binelli A, (2019) First evidence of protein modulation by polystyrene microplastics in a freshwater biological model. Environ Pollut 250:407\u2013415. https:\/\/doi.org\/10.1016\/j.envpol.2019.04.088","DOI":"10.1016\/j.envpol.2019.04.088"},{"issue":"3","key":"18218_CR38","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","volume":"47","author":"MG MarklundS","year":"1974","unstructured":"MarklundS MG (1974) Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 47(3):469\u2013474. https:\/\/doi.org\/10.1111\/j.1432-1033.1974.tb03714.x","journal-title":"Eur J Biochem"},{"key":"18218_CR39","doi-asserted-by":"publisher","first-page":"114634","DOI":"10.1016\/j.envpol.2020.114634","volume":"263","author":"O Missawi","year":"2020","unstructured":"Missawi O, Bousserrhine N, Belbekhouche S, Zitouni N, Alphonse V, Boughattas I, Banni M (2020) Abundance and distribution of small microplastics (\u2264 3 \u03bcm) in sediments and seaworms from the Southern Mediterranean coasts and characterisation of their potential harmful effects. Environ Pollut 263:114634","journal-title":"Environ Pollut"},{"issue":"10","key":"18218_CR40","doi-asserted-by":"publisher","first-page":"2172","DOI":"10.1002\/jcp.25330","volume":"231","author":"P Pariante","year":"2016","unstructured":"Pariante P, Dotolo R, Venditti M, Ferrara D, Donizetti A, Aniello F, Minucci S (2016) First Evidence of DAAM1 Localization during the post-natal development of rat testis and in mammalian sperm. J Cell Physiol 231(10):2172\u20132184. https:\/\/doi.org\/10.1002\/jcp.25330","journal-title":"J Cell Physiol"},{"key":"18218_CR41","doi-asserted-by":"publisher","first-page":"203","DOI":"10.3389\/fimmu.2020.00203","volume":"11","author":"Y Park","year":"2020","unstructured":"Park Y, Abihssira-Garc\u00eda IS, Thalmann S, Wiegertjes GF, Barreda DR, Olsvik PA, Kiron V (2020) Imaging flow cytometry protocols for examining phagocytosis of microplastics and bioparticles by immune cells of aquatic animals. Front Immunol 11:203. https:\/\/doi.org\/10.3389\/fimmu.2020.00203","journal-title":"Front Immunol"},{"key":"18218_CR42","first-page":"37","volume":"111","author":"MD Prokic","year":"2019","unstructured":"Prokic MD, Radovanovi\u0107 TB, Gavri\u0107 JP, Faggio C (2019) Ecotoxicological effects of microplastics: examination of biomarkers, current state and future perspectives. TrAC 111:37\u201346","journal-title":"TrAC"},{"key":"18218_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2019.07.065","volume":"236","author":"R Qiao","year":"2019","unstructured":"Qiao R, Deng Y, Zhang S, Wolosker MB, Zhu Q, Ren H, Zhang Y (2019) Accumulation of different shapes of microplastics initiates intestinal injury and gut microbiota dysbiosis in the gut of zebrafish. Chemosphere 236:124334. https:\/\/doi.org\/10.1016\/j.chemosphere.2019.07.065","journal-title":"Chemosphere"},{"key":"18218_CR44","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/0003-2697(68)90092-4","volume":"24","author":"J Sedlack","year":"1968","unstructured":"Sedlack J, Lindsay RH (1968) Measurement of protein sulfhydrils with the Ellman\u2019s reagent. Anal Biochem 24:192\u2013205","journal-title":"Anal Biochem"},{"issue":"9","key":"18218_CR45","doi-asserted-by":"publisher","first-page":"2430","DOI":"10.1073\/pnas.1519019113","volume":"113","author":"R Sussarellu","year":"2016","unstructured":"Sussarellu R, Suquet M, Thomas Y, Lambert C, Fabioux C, Pernet ME, Huvet A (2016) Oyster reproduction is affected by exposure to polystyrene microplastics. Proc Natl Acad Sci U S A 113(9):2430\u20132435. https:\/\/doi.org\/10.1073\/pnas.1519019113","journal-title":"Proc Natl Acad Sci U S A"},{"key":"18218_CR46","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.ecoenv.2021.112012","volume":"110","author":"R Triebskorn","year":"2019","unstructured":"Triebskorn R, Braunbeck T, Grummt T, Hanslik L, Huppertsberg S, Jekel M, K\u00f6hler R (2019) Relevance of nano-and microplastics for freshwater ecosystems: a critical review. Analyt Chem 110:375\u2013392. https:\/\/doi.org\/10.1016\/j.ecoenv.2021.112012","journal-title":"Analyt Chem"},{"issue":"3","key":"18218_CR47","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/s1534-5807(03)00266-1","volume":"5","author":"MT Veeman","year":"2003","unstructured":"Veeman MT, Axelrod JD, Moon RT (2003) A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling. Dev Cell 5(3):367\u2013377. https:\/\/doi.org\/10.1016\/s1534-5807(03)00266-1","journal-title":"Dev Cell"},{"issue":"475","key":"18218_CR48","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.mce.2018.02.007","volume":"5","author":"C Vigui\u00e9","year":"2018","unstructured":"Vigui\u00e9 C, Mhaouty-Kodja S, Habert R, Chevrier C, C\u00e9cile Michel C, Pasquier E (2018) Evidence-based adverse outcome pathway approach for the identification of BPA as en endocrine disruptor in relation to its effect on the estrous cycle. Mol Cell Endocrinol 5(475):10\u201328. https:\/\/doi.org\/10.1016\/j.mce.2018.02.007","journal-title":"Mol Cell Endocrinol"},{"key":"18218_CR49","doi-asserted-by":"publisher","unstructured":"Volkheimer G, Schulz FH (1968) The phenomenon of persorption: persorption, dissemination, and elimination of microparticles. Digestion 1:213\u2013218. https:\/\/doi.org\/10.1159\/000196856","DOI":"10.1159\/000196856"},{"key":"18218_CR50","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.chemosphere.2018.11.070","volume":"217","author":"Z Wan","year":"2019","unstructured":"Wan Z, Wang C, Zhou J, Shen M, Wang X, Fu Z, Jin Y (2019) Effects of polystyrene microplastics on the composition of the microbiome and metabolism in larval zebrafish. Chemosphere 217:646\u2013658. https:\/\/doi.org\/10.1016\/j.chemosphere.2018.11.070","journal-title":"Chemosphere"},{"issue":"22","key":"18218_CR51","doi-asserted-by":"publisher","first-page":"32554","DOI":"10.18632\/oncotarget.8689","volume":"7","author":"T Wang","year":"2016","unstructured":"Wang T, Han J, Duan X, Xiong B, Cui XS, Kim NH, Sun SC (2016) The toxic effects and possible mechanisms of Bisphenol A on oocyte maturation of porcine in vitro. Oncotarget 7(22):32554\u201332565. https:\/\/doi.org\/10.18632\/oncotarget.8689","journal-title":"Oncotarget"},{"key":"18218_CR52","doi-asserted-by":"publisher","first-page":"8823","DOI":"10.1021\/es501090e","volume":"48","author":"AJR Watts","year":"2014","unstructured":"Watts AJR, Lewis C, Goodhead RM, Becket SJ, Moger J, Tyler CR, Galloway TS (2014) Uptake and retention of microplastics by the shore crab Carcinus maenas. Environ Sci Technol 48:8823\u20138830. https:\/\/doi.org\/10.1021\/es501090e","journal-title":"Environ Sci Technol"},{"key":"18218_CR53","doi-asserted-by":"publisher","first-page":"381","DOI":"10.3389\/fncel.2015.00381","volume":"9","author":"C Wilson","year":"2015","unstructured":"Wilson C, Gonz\u00e1lez-Billault C (2015) Regulation of cytoskeletal dynamics by redox signaling and oxidative stress: implications for neuronal development and trafficking. Front Cell Neurosci 9:381. https:\/\/doi.org\/10.3389\/fncel.2015.00381","journal-title":"Front Cell Neurosci"},{"issue":"23","key":"18218_CR54","doi-asserted-by":"publisher","first-page":"R1031","DOI":"10.1016\/j.cub.2013.10.068","volume":"23","author":"SL Wright","year":"2013","unstructured":"Wright SL, Rowe D, Thompson RC, Galloway TS (2013) Microplastic ingestion decreases energy reserves in marine worms. Curr Biol 23(23):R1031-1033. https:\/\/doi.org\/10.1016\/j.cub.2013.10.068","journal-title":"Curr Biol"},{"issue":"12","key":"18218_CR55","doi-asserted-by":"publisher","first-page":"6634","DOI":"10.1021\/acs.est.7b00423","volume":"51","author":"SL Wright","year":"2017","unstructured":"Wright SL, Kelly FJ (2017) Plastic and human health: a micro issue? Environ Sci Technol 51(12):6634\u20136647. https:\/\/doi.org\/10.1021\/acs.est.7b00423","journal-title":"Environ Sci Technol"},{"key":"18218_CR56","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2019.110133","volume":"190","author":"X Xie","year":"2020","unstructured":"Xie X, Deng T, Duan J, Xie J, Yuan J, Chen M (2020) Exposure to polystyrene microplastics causes reproductive toxicity through oxidative stress and activation of the p38 MAPK signaling pathway. Ecotoxicol Environ Saf 190:110133. https:\/\/doi.org\/10.1016\/j.ecoenv.2019.110133","journal-title":"Ecotoxicol Environ Saf"},{"issue":"2","key":"18218_CR57","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/0006-2944(76)90049-1","volume":"15","author":"K Yagi","year":"1976","unstructured":"Yagi K (1976) A simple fluorometric assay for lipoperoxide in blood plasma. Biochem Med 15(2):212\u2013216. https:\/\/doi.org\/10.1016\/0006-2944(76)90049-1","journal-title":"Biochem Med"},{"issue":"5","key":"18218_CR58","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1083\/jcb.201502043","volume":"211","author":"T Yasunaga","year":"2015","unstructured":"Yasunaga T, Hoff S, Schell C, Helmst\u00e4dter M, Kretz O, Kuechlin S, Walz G (2015) The polarity protein inturned links NPHP4 to Daam1 to control the subapical actin network in multiciliated cells. J Cell Biol 211(5):963\u2013973. https:\/\/doi.org\/10.1083\/jcb.201502043","journal-title":"J Cell Biol"},{"key":"18218_CR59","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/j.jhazmat.2018.12.048","volume":"366","author":"YF Yang","year":"2019","unstructured":"Yang YF, Chen CY, Lu TH, Liao CM (2019) Toxicity-based toxicokinetic\/toxicodynamic assessment for bioaccumulation of polystyrene microplastics in mice. J Hazard Mater 366:703\u2013713. https:\/\/doi.org\/10.1016\/j.jhazmat.2018.12.048","journal-title":"J Hazard Mater"},{"key":"18218_CR60","doi-asserted-by":"publisher","first-page":"33904","DOI":"10.1038\/srep33904","volume":"6","author":"Y Zhang","year":"2016","unstructured":"Zhang Y, Han J, Zhu CC, Cui TF, XS, Kim NH, Sun SC, (2016) Exposure to HT-2 toxin causes oxidative stress induced apoptosis\/autophagy in porcine oocytes. Sci Rep 6:33904. https:\/\/doi.org\/10.1038\/srep33904","journal-title":"Sci Rep"},{"key":"18218_CR61","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2020.115564","volume":"173","author":"K Zhu","year":"2020","unstructured":"Zhu K, Jia H, Sun Y, Dai Y, Zhang C, Guo X, Zhu L (2020) Long-term phototransformation of microplastics under simulated sunlight irradiation in aquatic environments: roles of reactive oxygen species. Water Res 173:115564. https:\/\/doi.org\/10.1016\/j.watres.2020.115564","journal-title":"Water Res"},{"key":"18218_CR62","doi-asserted-by":"publisher","unstructured":"Zitouni N, BousserrhineN Belbekhouche S, Missawi O, Alphonse V, Boughatass I, Banni M (2020) First report on the presence of small microplastics (\u2264 3 \u03bcm) in tissue of the commercial fish Serranus scriba (Linnaeus. 1758) from Tunisian coasts and associated cellular alterations. Environ Pollut 263(Pt A):114576. https:\/\/doi.org\/10.1016\/j.envpol.2020.114576","DOI":"10.1016\/j.envpol.2020.114576"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-021-18218-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11356-021-18218-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-021-18218-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T07:05:13Z","timestamp":1651820713000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11356-021-18218-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,18]]},"references-count":62,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["18218"],"URL":"https:\/\/doi.org\/10.1007\/s11356-021-18218-3","relation":{},"ISSN":["0944-1344","1614-7499"],"issn-type":[{"value":"0944-1344","type":"print"},{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,18]]},"assertion":[{"value":"2 August 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 December 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 January 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The experiments were approved by the local ethics committee of Institute of Biotechnology, University of Monastir, Ref: CER-SVS\/ISBM022\/2020.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}