{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:31:27Z","timestamp":1772119887714,"version":"3.50.1"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"34","license":[{"start":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T00:00:00Z","timestamp":1646697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T00:00:00Z","timestamp":1646697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100014718","name":"innovative research group project of the national natural science foundation of china","doi-asserted-by":"publisher","award":["81773478"],"award-info":[{"award-number":["81773478"]}],"id":[{"id":"10.13039\/100014718","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"natural science foundation of\u00a0hunan province","doi-asserted-by":"publisher","award":["2019JJ40402"],"award-info":[{"award-number":["2019JJ40402"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1007\/s11356-022-19118-w","type":"journal-article","created":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T20:02:33Z","timestamp":1646683353000},"page":"52289-52301","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Clusterin protects against Cr(VI)-induced oxidative stress-associated hepatotoxicity by mediating the Akt-Keap1-Nrf2 signaling pathway"],"prefix":"10.1007","volume":"29","author":[{"given":"Yu","family":"Ma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siwen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sixuan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuzi","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ningjuan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuehui","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,3,8]]},"reference":[{"key":"19118_CR1","doi-asserted-by":"publisher","first-page":"420578","DOI":"10.1155\/2008\/420578","volume":"2008","author":"EC Alexopoulos","year":"2008","unstructured":"Alexopoulos EC, Cominos X, Trougakos IP, Lourda M, Gonos ES, Makropoulos V (2008) Biological monitoring of hexavalent chromium and serum levels of the senescence biomarker apolipoprotein J\/Clusterin in welders. Bioinorg Chem Appl 2008:420578","journal-title":"Bioinorg Chem Appl"},{"key":"19118_CR2","doi-asserted-by":"publisher","first-page":"S8","DOI":"10.1006\/rtph.1997.1133","volume":"26","author":"TC Aw","year":"1997","unstructured":"Aw TC (1997) Clinical and epidemiological data on lung cancer at a chromate plant. Regul Toxicol Pharmacol 26:S8-s12","journal-title":"Regul Toxicol Pharmacol"},{"key":"19118_CR3","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/S0891-5849(96)00352-8","volume":"22","author":"D Bagchi","year":"1997","unstructured":"Bagchi D, Vuchetich PJ, Bagchi M, Hassoun EA, Tran MX, Tang L, Stohs SJ (1997) Induction of oxidative stress by chronic administration of sodium dichromate [chromium VI] and cadmium chloride [cadmium II] to rats. Free Radic Biol Med 22:471\u2013478","journal-title":"Free Radic Biol Med"},{"key":"19118_CR4","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/S0300-483X(02)00378-5","volume":"180","author":"D Bagchi","year":"2002","unstructured":"Bagchi D, Stohs SJ, Downs BW, Bagchi M, Preuss HG (2002) Cytotoxicity and oxidative mechanisms of different forms of chromium. Toxicology 180:5\u201322","journal-title":"Toxicology"},{"key":"19118_CR5","doi-asserted-by":"crossref","unstructured":"Bajpai VK, Alam MB, Quan KT, Kwon KR, Ju MK, Choi HJ, Lee JS, Yoon JI, Majumder R, Rather IA, Kim K, Lee SH, Na M (2017) Antioxidant efficacy and the upregulation of Nrf2-mediated HO-1 expression by (+)-lariciresinol, a lignan isolated from Rubia philippinensis, through the activation of p38. Sci Rep 7:46035","DOI":"10.1038\/srep46035"},{"key":"19118_CR6","doi-asserted-by":"publisher","first-page":"22378","DOI":"10.1074\/jbc.M112.444182","volume":"288","author":"KL Cheung","year":"2013","unstructured":"Cheung KL, Lee JH, Shu L, Kim JH, Sacks DB, Kong AN (2013) The Ras GTPase-activating-like protein IQGAP1 mediates Nrf2 protein activation via the mitogen-activated protein kinase\/extracellular signal-regulated kinase (ERK) kinase (MEK)-ERK pathway. J Biol Chem 288:22378\u201322386","journal-title":"J Biol Chem"},{"issue":"1","key":"19118_CR7","doi-asserted-by":"publisher","first-page":"60","DOI":"10.3390\/antiox10010060","volume":"10","author":"MG Detsika","year":"2021","unstructured":"Detsika MG, Lianos EA (2021) Regulation of complement activation by heme oxygenase-1 (HO-1) in kidney injury. Antioxidants (basel) 10(1):60","journal-title":"Antioxidants (basel)"},{"key":"19118_CR8","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1080\/15376510309845","volume":"13","author":"SK Dey","year":"2003","unstructured":"Dey SK, Roy S, Chatterjee AK (2003) Effect of chromium on certain aspects of metabolic toxicities. Toxicol Mech Methods 13:89\u201395","journal-title":"Toxicol Mech Methods"},{"key":"19118_CR9","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/S0300-483X(03)00088-X","volume":"188","author":"A Gambelunghe","year":"2003","unstructured":"Gambelunghe A, Piccinini R, Ambrogi M, Villarini M, Moretti M, Marchetti C, Abbritti G, Muzi G (2003) Primary DNA damage in chrome-plating workers. Toxicology 188:187\u2013195","journal-title":"Toxicology"},{"key":"19118_CR10","doi-asserted-by":"publisher","first-page":"3745","DOI":"10.1038\/onc.2011.92","volume":"30","author":"EM Goetz","year":"2011","unstructured":"Goetz EM, Shankar B, Zou Y, Morales JC, Luo X, Araki S, Bachoo R, Mayo LD, Boothman DA (2011) ATM-dependent IGF-1 induction regulates secretory clusterin expression after DNA damage and in genetic instability. Oncogene 30:3745\u20133754","journal-title":"Oncogene"},{"key":"19118_CR11","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1093\/mutage\/gei043","volume":"20","author":"M Goulart","year":"2005","unstructured":"Goulart M, Bator\u00e9u MC, Rodrigues AS, Laires A, Rueff J (2005) Lipoperoxidation products and thiol antioxidants in chromium exposed workers. Mutagenesis 20:311\u2013315","journal-title":"Mutagenesis"},{"key":"19118_CR12","doi-asserted-by":"publisher","first-page":"G1","DOI":"10.1152\/ajpgi.00001.2006","volume":"291","author":"D Han","year":"2006","unstructured":"Han D, Hanawa N, Saberi B, Kaplowitz N (2006) Mechanisms of liver injury. III. Role of glutathione redox status in liver injury. Am J Physiol Gastrointest Liver Physiol 291:G1-7","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"19118_CR13","doi-asserted-by":"crossref","unstructured":"Hassan ZK, Elobeid MA, Virk P, Omer SA, ElAmin M, Daghestani MH, AlOlayan EM (2012) Bisphenol A induces hepatotoxicity through oxidative stress in rat model. Oxidative Med Cell Longev 194829","DOI":"10.1155\/2012\/194829"},{"key":"19118_CR14","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1161\/01.RES.85.8.663","volume":"85","author":"S Hayashi","year":"1999","unstructured":"Hayashi S, Takamiya R, Yamaguchi T, Matsumoto K, Tojo SJ, Tamatani T, Kitajima M, Makino N, Ishimura Y, Suematsu M (1999) Induction of heme oxygenase-1 suppresses venular leukocyte adhesion elicited by oxidative stress: role of bilirubin generated by the enzyme. Circ Res 85:663\u2013671","journal-title":"Circ Res"},{"key":"19118_CR15","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1093\/toxsci\/kfm081","volume":"98","author":"X He","year":"2007","unstructured":"He X, Lin GX, Chen MG, Zhang JX, Ma Q (2007) Protection against chromium (VI)-induced oxidative stress and apoptosis by Nrf2. Recruiting Nrf2 into the nucleus and disrupting the nuclear Nrf2\/Keap1 association. Toxicol Sci 98:298\u2013309","journal-title":"Toxicol Sci"},{"key":"19118_CR16","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1021\/tx100389r","volume":"24","author":"C Hu","year":"2011","unstructured":"Hu C, Eggler AL, Mesecar AD, van Breemen RB (2011) Modification of keap1 cysteine residues by sulforaphane. Chem Res Toxicol 24:515\u2013521","journal-title":"Chem Res Toxicol"},{"key":"19118_CR17","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1016\/j.jnutbio.2015.08.001","volume":"26","author":"Y Huang","year":"2015","unstructured":"Huang Y, Li W, Su ZY, Kong AN (2015) The complexity of the Nrf2 pathway: beyond the antioxidant response. J Nutr Biochem 26:1401\u20131413","journal-title":"J Nutr Biochem"},{"key":"19118_CR18","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/S1357-2725(01)00155-8","volume":"34","author":"SE Jones","year":"2002","unstructured":"Jones SE, Jomary C (2002) Clusterin. Int J Biochem Cell Biol 34:427\u2013431","journal-title":"Int J Biochem Cell Biol"},{"key":"19118_CR19","doi-asserted-by":"crossref","unstructured":"Kajarabille N, Latunde-Dada GO (2019) Programmed cell-death by ferroptosis: antioxidants as mitigators. Int J Mol Sci 20:4968","DOI":"10.3390\/ijms20194968"},{"key":"19118_CR20","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1097\/00007890-200210150-00001","volume":"74","author":"M Katori","year":"2002","unstructured":"Katori M, Busuttil RW, Kupiec-Weglinski JW (2002) Heme oxygenase-1 system in organ transplantation. Transplantation 74:905\u2013912","journal-title":"Transplantation"},{"key":"19118_CR21","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1007\/BF01973713","volume":"65","author":"E Kim","year":"1991","unstructured":"Kim E, Na KJ (1991) Nephrotoxicity of sodium dichromate depending on the route of administration. Arch Toxicol 65:537\u2013541","journal-title":"Arch Toxicol"},{"key":"19118_CR22","doi-asserted-by":"publisher","first-page":"11590","DOI":"10.1074\/jbc.M209233200","volume":"278","author":"KS Leskov","year":"2003","unstructured":"Leskov KS, Klokov DY, Li J, Kinsella TJ, Boothman DA (2003) Synthesis and functional analyses of nuclear clusterin, a cell death protein. J Biol Chem 278:11590\u201311600","journal-title":"J Biol Chem"},{"key":"19118_CR23","doi-asserted-by":"publisher","first-page":"123933","DOI":"10.1016\/j.jhazmat.2020.123933","volume":"402","author":"S Li","year":"2021","unstructured":"Li S, Shi M, Wang Y, Xiao Y, Cai D, Xiao F (2021a) Keap1-Nrf2 pathway up-regulation via hydrogen sulfide mitigates polystyrene microplastics induced-hepatotoxic effects. J Hazard Mater 402:123933","journal-title":"J Hazard Mater"},{"key":"19118_CR24","doi-asserted-by":"publisher","first-page":"126025","DOI":"10.1016\/j.jhazmat.2021.126025","volume":"417","author":"S Li","year":"2021","unstructured":"Li S, Ma Y, Ye S, Tang S, Liang N, Liang Y, Xiao F (2021b) Polystyrene microplastics trigger hepatocyte apoptosis and abnormal\n glycolytic flux via ROS-driven calcium overload. J Hazard Mater 417:126025","journal-title":"J Hazard Mater"},{"key":"19118_CR25","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/S1726-4901(09)70059-0","volume":"72","author":"CC Lin","year":"2009","unstructured":"Lin CC, Wu ML, Yang CC, Ger J, Tsai WJ, Deng JF (2009) Acute severe chromium poisoning after dermal exposure to hexavalent chromium. J Chin Med Assoc 72:219\u2013221","journal-title":"J Chin Med Assoc"},{"key":"19118_CR26","doi-asserted-by":"crossref","unstructured":"Linos A, Petralias A, Christophi CA, Christoforidou E, Kouroutou P, Stoltidis M, Veloudaki A, Tzala E, Makris KC, Karagas MR (2011) Oral ingestion of hexavalent chromium through drinking water and cancer mortality in an industrial area of Greece - an ecological study. Environ Health 10:50","DOI":"10.1186\/1476-069X-10-50"},{"key":"19118_CR27","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1007\/s12192-019-00977-1","volume":"24","author":"Q Liu","year":"2019","unstructured":"Liu Q, Jin Z, Xu Z, Yang H, Li L, Li G, Li F, Gu S, Zong S, Zhou J, Cao L, Wang Z, Xiao W (2019) Antioxidant effects of ginkgolides and bilobalide against cerebral ischemia injury by activating the Akt\/Nrf2 pathway in vitro and in vivo. Cell Stress Chaperones 24:441\u2013452","journal-title":"Cell Stress Chaperones"},{"key":"19118_CR28","doi-asserted-by":"crossref","unstructured":"Luo XQ, Suzuki M, Ghandhi SA, Amundson SA, Boothman DA (2014) ATM Regulates Insulin-Like Growth factor 1-secretory clusterin (IGF-1-sCLU) expression that protects cells against senescence. Plos One 9:e99983","DOI":"10.1371\/journal.pone.0099983"},{"key":"19118_CR29","doi-asserted-by":"publisher","first-page":"519","DOI":"10.3139\/113.110523","volume":"54","author":"MH Mondal","year":"2017","unstructured":"Mondal MH, Malik S, Garain A, Mandal S, Saha B (2017) Extraction of natural surfactant saponin from soapnut (Sapindus mukorossi) and its utilization in the remediation of hexavalent chromium from contaminated water. Tenside, Surfactants, Deterg 54:519\u2013529","journal-title":"Tenside, Surfactants, Deterg"},{"key":"19118_CR30","doi-asserted-by":"publisher","first-page":"516","DOI":"10.3139\/113.110654","volume":"56","author":"MH Mondal","year":"2019","unstructured":"Mondal MH, Ali MA, Pal A, Saha B (2019) A review on micellar catalyzed oxidation reactions of organic functional groups in aqueous medium using various transition metals. Tenside, Surfactants, Deterg 56:516\u2013525","journal-title":"Tenside, Surfactants, Deterg"},{"key":"19118_CR31","first-page":"349","volume":"139","author":"A Nigam","year":"2014","unstructured":"Nigam A, Priya S, Bajpai P, Kumar S (2014) Cytogenomics of hexavalent chromium (Cr 6+) exposed cells: a comprehensive review. Indian J Med Res 139:349\u2013370","journal-title":"Indian J Med Res"},{"key":"19118_CR32","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1002\/tox.20395","volume":"24","author":"AK Patlolla","year":"2009","unstructured":"Patlolla AK, Barnes C, Yedjou C, Velma VR, Tchounwou PB (2009) Oxidative stress, DNA damage, and antioxidant enzyme activity induced by hexavalent chromium in Sprague-Dawley rats. Environ Toxicol 24:66\u201373","journal-title":"Environ Toxicol"},{"key":"19118_CR33","doi-asserted-by":"publisher","first-page":"E4676","DOI":"10.1073\/pnas.1614943114","volume":"114","author":"L Quinti","year":"2017","unstructured":"Quinti L, Dayalan Naidu S, Tr\u00e4ger U, Chen X, Kegel-Gleason K, Ll\u00e8res D, Connolly C, Chopra V, Low C, Moniot S, Sapp E, Tousley AR, Vodicka P, Van Kanegan MJ, Kaltenbach LS, Crawford LA, Fuszard M, Higgins M, Miller JRC, Farmer RE, Potluri V, Samajdar S, Meisel L, Zhang N, Snyder A, Stein R, Hersch SM, Ellerby LM, Weerapana E, Schwarzschild MA, Steegborn C, Leavitt BR, Degterev A, Tabrizi SJ, Lo DC, DiFiglia M, Thompson LM, Dinkova-Kostova AT, Kazantsev AG (2017) KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington\u2019s disease patients. Proc Natl Acad Sci U S A 114:E4676-e4685","journal-title":"Proc Natl Acad Sci U S A"},{"key":"19118_CR34","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.taap.2007.07.004","volume":"224","author":"AI Rafael","year":"2007","unstructured":"Rafael AI, Almeida A, Santos P, Parreira I, Madeira VM, Alves R, Cabrita AM, Alpoim MC (2007) A role for transforming growth factor-beta apoptotic signaling pathway in liver injury induced by ingestion of water contaminated with high levels of Cr(VI). Toxicol Appl Pharmacol 224:163\u2013173","journal-title":"Toxicol Appl Pharmacol"},{"key":"19118_CR35","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1248\/jhs.52.142","volume":"52","author":"MV Rao","year":"2006","unstructured":"Rao MV, Parekh SS, Chawla SL (2006) Vitamin-E supplementation ameliorates chromium-and\/or nickel induced oxidative stress in vivo. J Health Sci 52:142\u2013147","journal-title":"J Health Sci"},{"key":"19118_CR36","doi-asserted-by":"publisher","first-page":"6157","DOI":"10.1021\/bi952981b","volume":"35","author":"KB Reddy","year":"1996","unstructured":"Reddy KB, Jin G, Karode MC, Harmony JA, Howe PH (1996) Transforming growth factor beta (TGF beta)-induced nuclear localization of apolipoprotein J\/clusterin in epithelial cells. Biochemistry 35:6157\u20136163","journal-title":"Biochemistry"},{"key":"19118_CR37","doi-asserted-by":"publisher","first-page":"e1153","DOI":"10.1038\/cddis.2014.118","volume":"5","author":"F Rizvi","year":"2014","unstructured":"Rizvi F, Shukla S, Kakkar P (2014) Essential role of PH domain and leucine-rich repeat protein phosphatase 2 in Nrf2 suppression via modulation of Akt\/GSK3beta\/Fyn kinase axis during oxidative hepatocellular toxicity. Cell Death Dis 5:e1153","journal-title":"Cell Death Dis"},{"key":"19118_CR38","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.cbi.2009.08.014","volume":"182","author":"DN Roy","year":"2009","unstructured":"Roy DN, Mandal S, Sen G, Biswas T (2009) Superoxide anion mediated mitochondrial dysfunction leads to hepatocyte apoptosis preferentially in the periportal region during copper toxicity in rats. Chem Biol Interact 182:136\u2013147","journal-title":"Chem Biol Interact"},{"key":"19118_CR39","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.etp.2010.04.005","volume":"63","author":"N Soudani","year":"2011","unstructured":"Soudani N, Ben Amara I, Sefi M, Boudawara T, Zeghal N (2011) Effects of selenium on chromium (VI)-induced hepatotoxicity in adult rats. Exp Toxicol Pathol 63:541\u2013548","journal-title":"Exp Toxicol Pathol"},{"key":"19118_CR40","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1111\/j.1365-2443.2010.01473.x","volume":"16","author":"K Taguchi","year":"2011","unstructured":"Taguchi K, Motohashi H, Yamamoto M (2011) Molecular mechanisms of the Keap1\u2013Nrf2 pathway in stress response and cancer evolution. Genes Cells 16:123\u2013140","journal-title":"Genes Cells"},{"key":"19118_CR41","first-page":"9056845","volume":"2019","author":"CT Wu","year":"2019","unstructured":"Wu CT, Deng JS, Huang WC, Shieh PC, Chung MI, Huang GJ (2019) Salvianolic acid C against acetaminophen-induced acute liver injury by attenuating inflammation, oxidative stress, and apoptosis through inhibition of the keap1\/Nrf2\/HO-1 signaling. Oxid Med Cell Longev 2019:9056845","journal-title":"Oxid Med Cell Longev"},{"key":"19118_CR42","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1039\/C8TX00231B","volume":"8","author":"Y Xiao","year":"2019","unstructured":"Xiao Y, Zeng M, Yin L, Li N, Xiao F (2019) Clusterin increases mitochondrial respiratory chain complex I activity and protects against hexavalent chromium-induced cytotoxicity in L-02 hepatocytes. Toxicol Res (camb) 8:15\u201324","journal-title":"Toxicol Res (camb)"},{"key":"19118_CR43","doi-asserted-by":"publisher","first-page":"5907","DOI":"10.1073\/pnas.97.11.5907","volume":"97","author":"CR Yang","year":"2000","unstructured":"Yang CR, Leskov K, Hosley-Eberlein K, Criswell T, Pink JJ, Kinsella TJ, Boothman DA (2000) Nuclear clusterin\/XIP8, an x-ray-induced Ku70-binding protein that signals cell death. Proc Natl Acad Sci U S A 97:5907\u20135912","journal-title":"Proc Natl Acad Sci U S A"},{"key":"19118_CR44","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1111\/jcpt.13044","volume":"45","author":"JH Yu","year":"2020","unstructured":"Yu JH, Lu JX, Smollin C, Cheng HT, Seak CJ, Chen HY (2020) N-acetylcysteine and ascorbic acid therapy for acute hepatic injury after hexavalent chromium ingestion. J Clin Pharm Ther 45:208\u2013210","journal-title":"J Clin Pharm Ther"},{"key":"19118_CR45","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1016\/j.spinee.2017.03.015","volume":"17","author":"CX Zhang","year":"2017","unstructured":"Zhang CX, Wang T, Ma JF, Liu Y, Zhou ZG, Wang DC (2017) Protective effect of CDDO-ethyl amide against high-glucose-induced oxidative injury via the Nrf2\/HO-1 pathway. Spine Journal 17:1017\u20131025","journal-title":"Spine Journal"},{"key":"19118_CR46","doi-asserted-by":"publisher","first-page":"109465","DOI":"10.1016\/j.ecoenv.2019.109465","volume":"183","author":"Y Zhang","year":"2019","unstructured":"Zhang Y, Zhang Y, Xiao Y, Zhong C, Xiao F (2019) Expression of clusterin suppresses Cr(VI)-induced premature senescence through activation of PI3K\/AKT pathway. Ecotoxicol Environ Saf 183:109465","journal-title":"Ecotoxicol Environ Saf"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-022-19118-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11356-022-19118-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-022-19118-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T04:12:50Z","timestamp":1657944770000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11356-022-19118-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,8]]},"references-count":46,"journal-issue":{"issue":"34","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["19118"],"URL":"https:\/\/doi.org\/10.1007\/s11356-022-19118-w","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-665264\/v1","asserted-by":"object"}]},"ISSN":["0944-1344","1614-7499"],"issn-type":[{"value":"0944-1344","type":"print"},{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,8]]},"assertion":[{"value":"8 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 March 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Animal experiments were carried out in accordance with the procedures approved by the Animal Care and Use Committee of Xiangya School of Public Health, Central South University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}