{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T11:26:36Z","timestamp":1778325996971,"version":"3.51.4"},"reference-count":160,"publisher":"Springer Science and Business Media LLC","issue":"28","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1007\/s11356-022-19770-2","type":"journal-article","created":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T10:44:40Z","timestamp":1648809880000},"page":"42404-42432","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Targeting natural products against SARS-CoV-2"],"prefix":"10.1007","volume":"29","author":[{"given":"Ahmed","family":"Al-Harrasi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0993-7708","authenticated-orcid":false,"given":"Tapan","family":"Behl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanuj","family":"Upadhyay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sridevi","family":"Chigurupati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shvetank","family":"Bhatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aayush","family":"Sehgal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saurabh","family":"Bhatia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sukhbir","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neelam","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shantini","family":"Vijayabalan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasanth Raj","family":"Palanimuthu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suprava","family":"Das","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajwinder","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lotfi","family":"Aleya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Bungau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,4,1]]},"reference":[{"key":"19770_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fpls.2016.00019","volume":"7","author":"CM Andre","year":"2016","unstructured":"Andre CM, Hausman JF, Guerriero G (2016) Cannabis sativa: the plant of the thousand and one molecules. Front Plant Sci 7:1\u201317","journal-title":"Front Plant Sci"},{"key":"19770_CR2","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1002\/cbdv.201500046","volume":"13","author":"PH Arato Ferreira","year":"2016","unstructured":"Arato Ferreira PH, dos Santos DAP, da Silva MFDG, Vieira PC, King-Diaz B, Lotina-Hennsen B, Veiga TAM (2016) Acridone alkaloids from Swinglea glutinosa (Rutaceae) and their effects on photosynthesis. Chem Biodivers 13:100\u2013106","journal-title":"Chem. Biodivers"},{"issue":"5","key":"19770_CR3","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1002\/ptr.2955","volume":"24","author":"A Astani","year":"2010","unstructured":"Astani A, Reichling J, Schnitzler P (2010) Comparative study on the antiviral activity of selected monoterpenes derived from essential oils. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives 24(5):673\u2013679","journal-title":"Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives"},{"key":"19770_CR4","first-page":"149","volume":"6","author":"A Astani","year":"2014","unstructured":"Astani A, Schnitzler P (2014) Antiviral activity of monoterpenes beta-pinene and limonene against herpes simplex virus in vitro. Iran J Microbiol 6:149\u2013155","journal-title":"Iran J Microbiol"},{"key":"19770_CR5","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/nn1665","volume":"9","author":"M Bandell","year":"2006","unstructured":"Bandell M, Dubin AE, Petrus MJ, Orth A, Mathur J, Hwang SW (2006) Patapoutian, A. High-throughput random mutagenesis screen reveals TRPM8 residues specifically required for activation by menthol. Nat Neurosci 9:493","journal-title":"Nat. Neurosci."},{"key":"19770_CR6","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1007\/BF02118655","volume":"42","author":"ML Barrett","year":"1986","unstructured":"Barrett ML, Scutt AM, Evans FJ (1986) Cannflavin A and B, prenylated flavones from Cannabis sativa L. Experientia 42:452\u2013453","journal-title":"Experientia"},{"key":"19770_CR7","doi-asserted-by":"publisher","first-page":"6642","DOI":"10.3390\/v7122963","volume":"7","author":"M Berry","year":"2015","unstructured":"Berry M, Fielding B, Gamieldien J (2015) Potential broad spectrum inhibitors of the coronavirus 3CLpro: a virtual screening and structure-based drug design study. Viruses 7:6642\u20136660","journal-title":"Viruses"},{"key":"19770_CR8","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.janh.2017.02.001","volume":"3","author":"K Brook","year":"2017","unstructured":"Brook K, Bennett J, Desai SP (2017) The chemical history of morphine: an 8000-year journey, from resin to de-novo synthesis. J Anesth Hist 3:50\u201355","journal-title":"J Anesth Hist"},{"key":"19770_CR9","doi-asserted-by":"crossref","unstructured":"Bulduk, Gezer B, Cengiz M. (2015) Optimization of Ultrasound-Assisted Extraction of Morphine from Capsules of Papaver somniferum by Response Surface Methodology. Int J Anal Chem 20151\u201320158","DOI":"10.1155\/2015\/796349"},{"issue":"12","key":"19770_CR10","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.2174\/138955708786140990","volume":"8","author":"P Buzzini","year":"2008","unstructured":"Buzzini P, Arapitsas P, Goretti M, Branda E, Turchetti B, Pinelli P, Romani A (2008) Antimicrobial and antiviral activity of hydrolysable tannins. Mini-Rev Med Chem 8(12):1179","journal-title":"Mini-Rev Med Chem"},{"key":"19770_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.antiviral.2014.11.010","volume":"114","author":"J Cao","year":"2015","unstructured":"Cao J, Forrest JC, Zhang X (2015) A screen of the NIH clinical collection small molecule library identifies potential anti-coronavirus drugs. Antiviral Res 114:1\u201310","journal-title":"Antiviral Res"},{"key":"19770_CR12","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1038\/39807","volume":"389","author":"MJ Caterina","year":"1997","unstructured":"Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D (1997) The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389:816","journal-title":"Nature"},{"issue":"6","key":"19770_CR13","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1007\/BF02976342","volume":"18","author":"J Chang","year":"1995","unstructured":"Chang J, Cho JH, Lee KHH, Lee KP, Han MW, Lee SS (1995) Antitumor activity of pedunculagin, one of the ellagitannin. Arch Pharmacal Res 18(6):396","journal-title":"Arch Pharmacal Res"},{"key":"19770_CR14","first-page":"1","volume":"2012","author":"SJ Chang","year":"2012","unstructured":"Chang SJ, Chang YC, Lu KZ, Tsou YY, Lin CW (2012) Antiviral activity of Isatis indigotica extract and its derived indirubin against Japanese encephalitis virus. Evid Based Complement Altern Med 2012:1\u20137","journal-title":"Evid Based Complement Altern Med"},{"issue":"9","key":"19770_CR15","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1016\/j.neuropsychologia.2004.12.015","volume":"43","author":"SHA Chen","year":"2005","unstructured":"Chen SHA, Desmond JE (2005b) Temporal dynamics of cerebro-cerebellar network recruitment during a cognitive task. Neuropsychologia 43(9):1227\u20131237","journal-title":"Neuropsychologia"},{"key":"19770_CR16","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1021\/acs.jnatprod.8b00239","volume":"81","author":"QB Chen","year":"2018","unstructured":"Chen QB, Gao J, Zou GA, Xin XL (2018a) A piperidine alkaloids with diverse skeletons from Anacyclus pyrethrum. J Nat Prod 81:1474\u20131482","journal-title":"J. Nat. Prod."},{"key":"19770_CR17","doi-asserted-by":"crossref","unstructured":"Chen L-C, Zhu Y, Papandreou G, Schroff F, Adam H (2018b) Encoderdecoder with atrous separable convolution for semantic image segmentation. In Proceedings of the European conference on computer vision (ECCV), pp 801\u2013818","DOI":"10.1007\/978-3-030-01234-2_49"},{"key":"19770_CR18","doi-asserted-by":"publisher","first-page":"3058","DOI":"10.1016\/j.bmcl.2005.04.027","volume":"15","author":"LR Chen","year":"2005","unstructured":"Chen LR, Wang YC, Lin YW, Chou SY, Chen SF, Liu LT, Juang SH (2005a) Synthesis and evaluation of isatin derivatives as effective SARS coronavirus 3CL protease inhibitors. Bioorg Med Chem Lett 15:3058\u20133062","journal-title":"Bioorg Med Chem Lett"},{"key":"19770_CR19","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/S1470-2045(08)70285-7","volume":"10","author":"A-L Cheng","year":"2009","unstructured":"Cheng A-L, Kang Y-K, Chen Z, Tsao C-J, Qin S, Kim JS, Luo R et al (2009) Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol 10:125\u201334","journal-title":"Lancet Oncol"},{"key":"19770_CR20","doi-asserted-by":"crossref","unstructured":"Cheng F, Wu J, Fang L, Wang X (2012) Syntenic gene analysis between Brassica rapa and other Brassicaceae species. Frontiers Plant Sci 3198","DOI":"10.3389\/fpls.2012.00198"},{"key":"19770_CR21","unstructured":"Cheng (2020) Covid-19: risk factors for severe disease and death. Bmj 368"},{"key":"19770_CR22","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.3389\/fimmu.2020.01664","volume":"11","author":"S Choudhary","year":"2020","unstructured":"Choudhary S, Malik YS, Tomar S (2020) IdentificationofSARS-CoV-2cell entry inhibitors by drug repurposing using in silico structure based virtual screening approach. Front Immunol 11:1664","journal-title":"Front Immunol"},{"key":"19770_CR23","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.1016\/S0140-6736(03)13615-X","volume":"361","author":"J Cinatl","year":"2003","unstructured":"Cinatl J, Morgenstern B, Bauer G, Chandra P, Rabenau H, Doerr HW (2003) Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus. Lancet 361:2045\u20132046","journal-title":"Lancet"},{"key":"19770_CR24","unstructured":"Cronemberger Sebasti\u00e3o, Nassim Calixto, Marcelo Nacif Moraes, Iuri David Castro, Patr\u00edcia Cordeiro Lana, and Artur Furst Loredo. (2012) Efficacy of one drop of 2% pilocarpine to reverse the intraocular pressure peak at 6:00 am in early glaucoma. Vision Pan-America 11(1):14"},{"key":"19770_CR25","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.ijantimicag.2014.06.001","volume":"44","author":"TPT Cushnie","year":"2014","unstructured":"Cushnie TPT, Cushnie B, Lamb AJ (2014) Alkaloids: an overview of their antibacterial, antibiotic-enhancing and antivirulence activities. Int J Antimicrob Agents 44:377\u2013386","journal-title":"Int J Antimicrob Agents"},{"key":"19770_CR26","doi-asserted-by":"publisher","first-page":"23379","DOI":"10.1039\/D0RA03774E","volume":"10","author":"AA da Silva","year":"2020","unstructured":"da Silva AA, Wiedemann LSM, Veiga-Junior VF (2020) Natural products\u2019 role against COVID-19. RSC Adv 10:23379\u201323393","journal-title":"RSC Adv"},{"key":"19770_CR27","doi-asserted-by":"crossref","unstructured":"Dai J-P, Wang Q-W, Su Y, Gu L-M, Deng H-X, Chen X-X, Li W-Z, Li K-S (2018) Oxymatrine inhibits influenza A virus replication and inflammation via TLR4, p38 MAPK and NF-\u03baB pathways. Int J Mol Sci 19(4):965","DOI":"10.3390\/ijms19040965"},{"issue":"12","key":"19770_CR28","doi-asserted-by":"publisher","first-page":"e1192","DOI":"10.1016\/S2214-109X(17)30375-3","volume":"5","author":"L Degenhardt","year":"2017","unstructured":"Degenhardt L, Peacock A, Colledge S, Leung J, Grebely J, Vickerman P, Stone J et al (2017) Global prevalence of injecting drug use and sociodemographic characteristics and prevalence of HIV, HBV, and HCV in people who inject drugs: a multistage systematic review. The Lancet Global Health 5(12):e1192\u2013e1207","journal-title":"The Lancet Global Health"},{"key":"19770_CR29","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.antiviral.2018.11.011","volume":"161","author":"M Diosa-Toro","year":"2019","unstructured":"Diosa-Toro M, Troost B, van de Pol D, Heberle AM, Urcuqui-Inchima S, Thedieck K, Smit JM (2019) Tomatidine, a novel antiviral compound towards dengue virus. Antivir Res 161:90\u201399","journal-title":"Antivir Res"},{"key":"19770_CR30","doi-asserted-by":"crossref","first-page":"10","DOI":"10.4172\/2329-6836.1000163","volume":"3","author":"S Elzinga","year":"2015","unstructured":"Elzinga S, Fischedick J, Podkolinski R, Raber JC (2015) Cannabinoids and terpenes as chemotaxonomic markers in cannabis. Nat Prod Chem Res 3:10\u20134172","journal-title":"Nat Prod Chem Res"},{"key":"19770_CR31","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1002\/ddr.10213","volume":"59","author":"I Ero","year":"2003","unstructured":"Ero I, Abu Eida EY, Cs\u00f3ka I, S\u00e1nta Z, Cserne A, K\u00f6v\u00e9 T (2003) Optimization of drug release from dermatological semisolid preparations. Drug Dev Res 59:316\u2013325","journal-title":"Drug Dev Res"},{"issue":"2","key":"19770_CR32","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/S0014-5793(98)00450-5","volume":"427","author":"M Fellermeier","year":"1998","unstructured":"Fellermeier M, Zenk MH (1998) Prenylation of olivetolate by a hemp transferase yields cannabigerolic acid, the precursor of tetrahydrocannabinol. FEBS Lett 427(2):283\u2013285","journal-title":"FEBS Lett"},{"issue":"1","key":"19770_CR33","doi-asserted-by":"publisher","first-page":"101","DOI":"10.2174\/1570159X13666150716165726","volume":"14","author":"TH Ferreira-Vieira","year":"2016","unstructured":"Ferreira-Vieira TH, Guimaraes IM, Silva FR, Ribeiro FM (2016) Alzheimer\u2019s disease: targeting the cholinergic system. Curr Neuropharmacol 14(1):101\u2013115","journal-title":"Curr Neuropharmacol"},{"key":"19770_CR34","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1007\/s11101-008-9094-4","volume":"7","author":"IJ Flores-Sanchez","year":"2008","unstructured":"Flores-Sanchez IJ, Verpoorte R (2008) Secondary metabolism in cannabis. Phytochem Rev 7:615\u2013639","journal-title":"Phytochem Rev"},{"key":"19770_CR35","doi-asserted-by":"publisher","first-page":"2359","DOI":"10.1016\/j.jid.2020.03.962","volume":"140","author":"SB Forman","year":"2020","unstructured":"Forman SB, Pariser DM, Poulin Y, Vincent MS et al (2020) TYK2\/JAK1 inhibitor PF-06700841 in patients with plaque psoriasis: Phase IIa, randomized, double-blind, placebo controlled Trial. J Investig Dermatol 140:2359-2370.e5","journal-title":"J. Investig. Dermatol"},{"key":"19770_CR36","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1007\/BF00915771","volume":"12","author":"EA Formukong","year":"1998","unstructured":"Formukong EA, Evans AT, Evans FJ (1998) Analgesic and anti inflammatory activity of constituents of Cannabis sativa L. Inflammation 12:361\u2013371","journal-title":"Inflammation"},{"key":"19770_CR37","doi-asserted-by":"publisher","first-page":"e0124459","DOI":"10.1371\/journal.pone.0124459","volume":"10","author":"E Fossati","year":"2015","unstructured":"Fossati E, Narcross L, Ekins A, Martin Falgueyret J P (2015) Synthesis of morphinan alkaloids in Saccharomyces cerevisiae. PLoS ONE 10:e0124459","journal-title":"PLoS ONE"},{"key":"19770_CR38","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1056\/NEJMra1407304","volume":"373","author":"D Friedman","year":"2015","unstructured":"Friedman D, Devinsky O (2015) Cannabinoids in the treatment of epilepsy. N Engl J Med 373:1048\u20131058","journal-title":"N Engl J Med"},{"key":"19770_CR39","doi-asserted-by":"crossref","unstructured":"Funck-Brentano C, Salem\u00a0J  (2020)\u00a0Funck-Brentano, C, Salem J-E (2020) RETRACTED: Chloroquine or hydroxychloroquine for COVID-19: why might they be hazardous? The Lancet\u00a02020","DOI":"10.1016\/S0140-6736(20)31174-0"},{"key":"19770_CR40","doi-asserted-by":"publisher","first-page":"12811","DOI":"10.1073\/pnas.1200330109","volume":"109","author":"SJ Gagne","year":"2012","unstructured":"Gagne SJ, Stout JM, Liu E, Boubakir Z, Page CSM (2012) Identification of olivetolic acid cyclase from Cannabis sativa reveals a unique catalytic route to plant polyketides. Proc Natl Acad Sci USA 109:12811\u201312816","journal-title":"Proc Natl Acad Sci USA"},{"key":"19770_CR41","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/S0304-3940(01)02527-7","volume":"322","author":"N Galeotti","year":"2002","unstructured":"Galeotti N, Mannelli LDC, Mazzanti G, Bartolini A, Ghelardini C (2002) Menthol: a natural analgesic compound. Neurosci Lett 322:145\u2013148","journal-title":"Neurosci Lett"},{"key":"19770_CR42","doi-asserted-by":"publisher","first-page":"72","DOI":"10.5582\/bst.2020.01047","volume":"14","author":"J Gao","year":"2020","unstructured":"Gao J, Tian Z, Yang X (2020) Breakthrough: chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies. Biosci Trends 14:72\u201373","journal-title":"Biosci Trends"},{"key":"19770_CR43","doi-asserted-by":"crossref","unstructured":"Gautret P, Lagier JC, Parola P, Hoang VT, Meddeb L, Mailhe M, Doudier B, Courjon J, Giordanengo V, Vieira VE, T Dupont, Honor\u00b4e S, Colson P, Chabri`ere E, La Scola B, Rolain JM, Brouqui P and D Raoul (2020) Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. Int J Antimicrob Agents 56(1):105949","DOI":"10.1016\/j.ijantimicag.2020.105949"},{"key":"19770_CR44","doi-asserted-by":"publisher","first-page":"2463","DOI":"10.1111\/bcp.13618","volume":"84","author":"CPL Grof","year":"2018","unstructured":"Grof CPL (2018) Cannabis, from plant to pill. Br J Clin Pharmacol 84:2463\u20132467","journal-title":"Br J Clin Pharmacol"},{"key":"19770_CR45","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.fitote.2015.10.009","volume":"107","author":"W Gu","year":"2015","unstructured":"Gu W, Wang W, Li X, Zhang Y, Wang L, Yuan C, Huang L, Hao X (2015) A novel isocoumarin with anti-influenza virus activity from Strobilanthes cusia. Fitoterapia 107:60\u201362","journal-title":"Fitoterapia"},{"key":"19770_CR46","doi-asserted-by":"publisher","first-page":"212531","DOI":"10.7573\/dic.212531","volume":"7","author":"C Guerrero-Garc\u00eda","year":"2018","unstructured":"Guerrero-Garc\u00eda C, Rubio-Guerra AF (2018) Combination therapy in the treatment of hypertension. Drugs Context 7:212531","journal-title":"Drugs Context"},{"key":"19770_CR47","doi-asserted-by":"publisher","first-page":"2471","DOI":"10.3390\/molecules24132471","volume":"24","author":"AC Guimar\u00e3es","year":"2019","unstructured":"Guimar\u00e3es AC, Meireles LM, Lemos MF, Guimar\u00e3es MCC, Endringer DC, Fronza M, Scherer R (2019) Antibacterial activity of terpenes and terpenoids present in essential oils. Molecules 24:2471","journal-title":"Molecules"},{"key":"19770_CR48","first-page":"79","volume":"69","author":"JMR Gulland","year":"1952","unstructured":"Gulland JMR, Mem R (1952) Constitution of codeine and thebaine. Proc Manch Lit Phil Soc 69:79-86.6","journal-title":"Proc. Manch. Lit. Phil. Soc."},{"key":"19770_CR49","doi-asserted-by":"crossref","unstructured":"Gupta A, Bhati V, Kumar A (2021) Herbals for COVID-19 infection: COVID-19 Curr Chall Future Perspect 1: 160","DOI":"10.2174\/9789811498640121010016"},{"key":"19770_CR50","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/sj.bjp.0707442","volume":"153","author":"HO Gutzeit","year":"2008","unstructured":"Gutzeit HO, Ludwig-M\u00fcller J (2008) PlantNaturalProducts: Synthesis, Biological Functions and Practical Applications; John Wiley & Sons: Hoboken, NJ, USA, 2014. 105. Pertwee, R.G. The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: \u22069-tetrahydrocannabinol, cannabidiol and \u22069-tetrahydrocannabivarin. Br J Pharmacol 153:199\u2013215","journal-title":"Br J Pharmacol"},{"issue":"5","key":"19770_CR51","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.1080\/07391102.2020.1835726","volume":"40","author":"GA Gyebi","year":"2022","unstructured":"Gyebi GA, Adegunloye AP, Ibrahim IM, Ogunyemi OM, Afolabi SO, Ogunro OB (2022) Prevention of SARS-CoV-2 cell entry: insight from in silico interaction of drug-like alkaloids with spike glycoprotein, human ACE2, and TMPRSS2. J Biomol Struct Dyn 40(5):2121\u20132145","journal-title":"J Biomol Struct Dyn"},{"key":"19770_CR52","first-page":"09871","volume":"70","author":"JM Gyuris","year":"2004","unstructured":"Gyuris JM, Forgo P, Moln\u00e1r J, Hohmann J (2004) Alkaloids from Leucojum vernum and antiretroviral activity of Amaryllidaceae alkaloids. Planta Medica 70:09871\u2013873","journal-title":"Planta Medica"},{"key":"19770_CR53","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1089\/can.2016.0017","volume":"1","author":"A Hazekamp","year":"2016","unstructured":"Hazekamp A, Tejkalov\u00e1 K, Papadimitriou S (2016) Cannabis: from cultivar to chemovar II\u2014a metabolomics approach to Cannabis classification. Cannabis Cannabinoid Res 1:202\u2013215","journal-title":"Cannabis Cannabinoid Res"},{"key":"19770_CR54","doi-asserted-by":"publisher","first-page":"104391","DOI":"10.1016\/j.fitote.2019.104391","volume":"139","author":"LJ He","year":"2019","unstructured":"He LJ, Liu JS, Luo D, Zheng YR, Zhang YB, Wang GC, Li YL (2019) Quinolizidine alkaloids from Sophora tonkinensis and their anti-inflammatory activities. Fitoterapia. 139:104391","journal-title":"Fitoterapia."},{"key":"19770_CR55","doi-asserted-by":"crossref","unstructured":"He FG, Martinowich K, Chin MH, Fouse FSD, Hutnick L, Hattori C et al. (2005) DNA methylation controls the timing of astrogliogenesis through regulation of JAK-STAT signaling 3345-3356","DOI":"10.1242\/dev.01912"},{"key":"19770_CR56","first-page":"171","volume-title":"Analysis of Steroidal Alkaloids and Saponins in Solanaceae Plant Extracts Using UPLC-qTOF Mass Spectrometry","author":"U Heinig","year":"2014","unstructured":"Heinig U, Aharoni A (2014) Analysis of Steroidal Alkaloids and Saponins in Solanaceae Plant Extracts Using UPLC-qTOF Mass Spectrometry. Humana Press, New York, NY, USA, pp 171\u2013185"},{"key":"19770_CR57","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/j.1748-1716.1951.tb00824.x","volume":"24","author":"H Hensel","year":"1951","unstructured":"Hensel H (1951) Zotterman Y (1951) The effect of menthol on the thermoreceptors. Acta Physiol Scand 24:27\u201334","journal-title":"Acta Physiol Scand"},{"issue":"5","key":"19770_CR58","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1152\/jn.1951.14.5.377","volume":"14","author":"H Hensel","year":"1951","unstructured":"Hensel H, Zotterman Y (1951) Action potentials of cold fibres and intracutaneous temperature gradient. J Neurophys 14(5):377\u2013385","journal-title":"J Neurophys"},{"key":"19770_CR59","doi-asserted-by":"publisher","first-page":"1932","DOI":"10.1073\/pnas.87.5.1932","volume":"87","author":"M Herkenham","year":"1990","unstructured":"Herkenham M, Lynn AB, Little MD, Johnson MR, Melvin LS, de Costa BR, Rice KC (1990) Cannabinoid receptor localization in brain. Proc. Natl. Acad. Sci. 87:1932\u20131936","journal-title":"Proc. Natl. Acad. Sci."},{"key":"19770_CR60","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1016\/j.bbrc.2019.08.120","volume":"518","author":"YJ Ho","year":"2019","unstructured":"Ho YJ, Lu JW, Huang YL, Lai ZZ (2019) Palmatine inhibits Zika virus infection by disrupting virus binding, entry, and stability. Biochem Biophys Res Commun 518:732\u2013738","journal-title":"Biochem Biophys Res Commun"},{"key":"19770_CR61","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.phymed.2018.09.025","volume":"53","author":"TC Hung","year":"2019","unstructured":"Hung TC, Jassey A, Liu CH, Lin CJ, Lin CC, Wong SH, Wang JY, Yen MH (2019) Lin L T (2019) Berberine inhibits hepatitis C virus entry by targeting the viral E2 glycoprotein. Phytomedicine 53:62\u201369","journal-title":"Phytomedicine"},{"key":"19770_CR62","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1007\/s11606-020-05762-w","volume":"35","author":"F Jiang","year":"2020","unstructured":"Jiang F, Deng L, Zhang L, Cai Y, Cheung CW, Xia Z (2020) Review of the clinical characteristics of coronavirus disease 2019 (COVID-19). J Gen Intern Med 35:1545\u20131549","journal-title":"J Gen Intern Med"},{"issue":"6","key":"19770_CR63","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1111\/cbdd.13604","volume":"94","author":"S Jo","year":"2019","unstructured":"Jo S, Kim H, Kim S, Shin DH, Kim MS (2019) Characteristics of flavonoids as potent MERS-CoV 3C-like protease inhibitors. Chem Biol Drug Des 94(6):2023\u20132030","journal-title":"Chem Biol Drug Des"},{"key":"19770_CR64","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.phytochem.2015.09.001","volume":"119","author":"K Kang","year":"2015","unstructured":"Kang K, Ming B, G, Kim G J, Choi H, Oh W K, Sung S H, (2015) Jubanines F-J, cyclopeptide alkaloids from the roots of Ziziphus jujuba. Phytochemistry 119:90\u201395. https:\/\/doi.org\/10.1016\/j.phytochem.2015.09.001","journal-title":"Phytochemistry"},{"key":"19770_CR65","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1016\/j.bcp.2008.06.022","volume":"76","author":"BL Kaplan","year":"2008","unstructured":"Kaplan BL, Springs AE (2008) Kaminski N E (2008) The profile of immunemodulation by cannabidiol (CBD) involves deregulation of nuclear factor of activated T cells (NFAT). Biochem Pharmacol 76:726\u2013737","journal-title":"Biochem Pharmacol"},{"key":"19770_CR66","first-page":"1","volume":"1","author":"S Khaerunnisa","year":"2020","unstructured":"Khaerunnisa S, Kurniawan H, Awaluddin R, Suhartati S, Soetjipto S (2020) Potential inhibitor of COVID-19 main Protease (Mpro) from several medicinal plant compounds by molecular docking study. Prepr 1:1\u201314","journal-title":"Prepr"},{"issue":"2","key":"19770_CR67","doi-asserted-by":"publisher","first-page":"12","DOI":"10.26480\/asm.02.2017.12.15","volume":"1","author":"IU Khan","year":"2017","unstructured":"Khan IU, Sajid S, Javed A, Sajid S, Shah SU (2017) Comparative diagnosis of typhoid fever by polymerase chain reaction and widal test in Southern Districts (Bannu, Lakki Marwat and DI Khan) of Khyber Pakhtunkhwa. Pakistan. Acta Sci Malaysia 1(2):12\u201315","journal-title":"Pakistan. Acta Sci Malaysia"},{"key":"19770_CR68","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.4314\/tjpr.v14i10.28","volume":"14","author":"FA Khan","year":"2015","unstructured":"Khan FA, Maalik A (2015) Advances in pharmacology of isatin and its derivatives: a review. Trop J Pharm Res 14:1937\u20131942","journal-title":"Trop J Pharm Res"},{"key":"19770_CR69","doi-asserted-by":"publisher","first-page":"696","DOI":"10.3390\/biom9110696","volume":"9","author":"DE Kim","year":"2019","unstructured":"Kim DE, Min JS, Jang MS, Lee JY, Shin YS, Park CM, Jin YH (2019) Natural bis-benzylisoquinoline alkaloids-tetrandrine, fangchinoline, and cepharanthine, inhibit human coronavirus OC43 infection of MRC-5 human lung cells. Biomolecules 9:696","journal-title":"Biomolecules"},{"issue":"4","key":"19770_CR70","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1016\/j.cell.2020.04.011","volume":"181","author":"D Kim","year":"2020","unstructured":"Kim D, Lee J-Y, Yang J-S, Kim JW, Kim VN, Chang H (2020) The architecture of SARS-CoV-2 transcriptome. Cell 181(4):914\u2013921","journal-title":"Cell"},{"key":"19770_CR71","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.3390\/molecules21081078","volume":"21","author":"S Kishimoto","year":"2016","unstructured":"Kishimoto S, Sato M, Tsunematsu Y, Watanabe K (2016) Evaluation of biosynthetic pathway and engineered biosynthesis of alkaloids. Molecules 21:1078","journal-title":"Molecules"},{"key":"19770_CR72","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.antiviral.2006.01.011","volume":"70","author":"YC Kuo","year":"2006","unstructured":"Kuo YC, Kuo YH, Lin YL, Tsai WJ (2006) Yatein from Chamaecyparis obtusa suppresses herpes simplex virus type 1 replication in HeLa cells by interruption the immediate-early gene expression. Antiviral Res 70:112\u2013120","journal-title":"Antiviral Res"},{"key":"19770_CR73","doi-asserted-by":"publisher","first-page":"2803","DOI":"10.1111\/bph.12602","volume":"171","author":"BK Lau","year":"2014","unstructured":"Lau BK, Karim S, Goodchild AK, Vaughan CW, Drew GM (2014) Menthol enhances phasic and tonic GABAA receptor-mediated currents in midbrain periaqueductal grey neurons. Br J Pharmacol 171:2803\u20132813","journal-title":"Br J Pharmacol"},{"key":"19770_CR74","doi-asserted-by":"publisher","first-page":"10363","DOI":"10.1021\/jm300705j","volume":"55","author":"YZ Lee","year":"2012","unstructured":"Lee YZ, Yang CW, Hsu HY, Qiu YQ, Yeh TK, Chang HY, Chao YS, Lee SJ (2012) Synthesis and biological evaluation of tylophorine-derived dibenzoquinolines as orally active agents: exploration of the role of tylophorine E ring on biological activity. J Med Chem 55:10363\u201310377","journal-title":"J Med Chem"},{"key":"19770_CR75","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.antiviral.2005.02.007","volume":"67","author":"SY Li","year":"2005","unstructured":"Li SY, Chen C, Zhang Q, Guo HY, Wang H, Wang L, Xiao PG (2005) Identification of natural compounds with antiviral activities against SARS-associated coronavirus. Antiviral Res 67:18\u201323","journal-title":"Antiviral Res"},{"key":"19770_CR76","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.antiviral.2005.07.002","volume":"68","author":"CW Lin","year":"2005","unstructured":"Lin CW, Tsai FJ, Tsai CH, Lai CC, Wan L, Ho TY, Hsieh CC, Chao PDL (2005) Anti-SARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds. Antivir Res 68:36\u201342","journal-title":"Antivir Res"},{"issue":"9","key":"19770_CR77","doi-asserted-by":"publisher","first-page":"4386","DOI":"10.1128\/JVI.01492-10","volume":"85","author":"LT Lin","year":"2011","unstructured":"Lin LT, Chen TY, Chung CY, Noyce RS, Grindley TB, Mccormick C, Richardson CD (2011) Hydrolyzable tannins (chebulagic acid and punicalagin) target viral glycoprotein-glycosaminoglycan interactions to inhibit herpes simplex virus 1 entry and cell-to-cell spread. Virol 85(9):4386\u20134398","journal-title":"Virol"},{"issue":"1","key":"19770_CR78","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1006\/dbio.1997.8669","volume":"189","author":"Lin,","year":"1997","unstructured":"Lin (1997) Spectrosomes and Fusomes Anchor Mitotic Spindles during Asymmetric Germ Cell Divisions and Facilitate the Formation of a Polarized Microtubule Array for Oocyte Specification inDrosophila. Dev Biol 189(1):79\u201394","journal-title":"Dev Biol"},{"key":"19770_CR79","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1021\/bp025597w","volume":"18","author":"J Lin","year":"2002","unstructured":"Lin J, Qiu S, Lewis K, Klibanov AM (2002) Bactericidal properties of flat surfaces and nanoparticles derivatized with alkylated polyethylenimines. Biotechnol Prog 18:1082\u20131086","journal-title":"Biotechnol Prog"},{"key":"19770_CR80","doi-asserted-by":"publisher","first-page":"29","DOI":"10.2174\/157340609787049316","volume":"5","author":"GT Liu","year":"2009","unstructured":"Liu GT (2009) Bicyclol: a novel drug for treating chronic viral hepatitis B and C. Med Chem 5:29\u201343","journal-title":"Med Chem"},{"key":"19770_CR81","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.bmc.2013.11.028","volume":"22","author":"W Liu","year":"2014","unstructured":"Liu W, Zhu HM, Niu GJ, Shi EZ, Chen J, Sun B, Yang C (2014) Synthesis, modification and docking studies of 5-sulfonyl isatin derivatives as SARS-CoV 3C-like protease inhibitors. Bioorg Med Chem 22:292\u2013302","journal-title":"Bioorg Med Chem"},{"key":"19770_CR82","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.antiviral.2016.08.026","volume":"134","author":"C Liu","year":"2016","unstructured":"Liu C, Cai D, Zhang L, Tang W, Yan R, Guo H, Chen X (2016) Identification of hydrolyzable tannins (punicalagin, punicalin and geraniin) as novel inhibitors of hepatitis B virus covalently closed circular DNA. Antiviral Res 134:97\u2013107","journal-title":"Antiviral Res"},{"issue":"14","key":"19770_CR83","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1056\/NEJMc2003717","volume":"382","author":"W Liu","year":"2020","unstructured":"Liu W, Junbo Chen Z, Xiang R, Song H, Shu S, Chen L et al (2020) Detection of Covid-19 in children in early January 2020 in Wuhan. China. N Engl J Med 382(14):1370\u20131371","journal-title":"China. N Engl J Med"},{"key":"19770_CR84","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.antiviral.2019.02.006","volume":"164","author":"A Luganini","year":"2019","unstructured":"Luganini A, Mercorelli B, Messa L, Pal\u00f9 G, Gribaudo G (2019) Loregian A (2019) The isoquinoline alkaloid berberine inhibits human cytomegalovirus replication by interfering with the viral Immediate Early-2 (IE2) protein transactivating activity. Antivir Res 164:52\u201360","journal-title":"Antivir Res"},{"key":"19770_CR85","doi-asserted-by":"crossref","unstructured":"Macchiagodena M, Pagliai M, Procacci P (2020)\u00a0Identification of potential binders of the main protease 3CLpro of the COVID-19 via structure-based ligand design and molecular modeling. Chem Phys Lett 750137489","DOI":"10.1016\/j.cplett.2020.137489"},{"key":"19770_CR86","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.endeavour.2009.09.001","volume":"33","author":"AH Maehle","year":"2009","unstructured":"Maehle AH (2009) (2009) A binding question: the evolution of the receptor concept. Endeavour 33:135\u2013140","journal-title":"Endeavour"},{"key":"19770_CR87","doi-asserted-by":"crossref","unstructured":"Maier H J, Bickerton E, Britton P (2015) Coronaviruses Methods and Protocols; Humana Press: Heidelberg, Germany. pp. 1\u2013282. ISBN 9781493924387.","DOI":"10.1007\/978-1-4939-2438-7"},{"key":"19770_CR88","doi-asserted-by":"publisher","first-page":"4918","DOI":"10.2174\/0929867324666170523120656","volume":"25","author":"A Manayi","year":"2019","unstructured":"Manayi A, Nabavi SM, Setzer WN, Jafari S (2019) Piperine as a potential anti-cancer agent: a review on preclinical studies. Curr. Med. Chem. 25:4918\u20134928","journal-title":"Curr. Med. Chem."},{"key":"19770_CR89","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.phytochem.2014.10.026","volume":"109","author":"NJ Martin","year":"2020","unstructured":"Martin NJ, Ferreiro SF, Barbault F, Lecellier NM, Paetz G, Gaysinski C, Alonso M, Thomas E, Botana OP (2020) Indole alkaloids from the Marquesan plant Rauvolfia nukuhivensis and their effects on ion channels. Phytochemistry 109:84\u201395","journal-title":"Phytochemistry"},{"key":"19770_CR90","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1038\/346561a0","volume":"346","author":"LA Matsuda","year":"1990","unstructured":"Matsuda LA, Lolait SJ, Brownstein MJ, Young AC (1990) Bonner, T.I. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346:561","journal-title":"Nature"},{"key":"19770_CR91","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1128\/AAC.39.2.484","volume":"39","author":"JB McMahon","year":"1995","unstructured":"McMahon JB, Currens MJ, Gulakowski RJ, Buckheit RW, Lackman-Smith C, Hallock YF, Boyd MR (1995) Michellamine B, a novel plant alkaloid, inhibits human immunodeficiency virus-induced cell killing by at least two distinct mechanisms. Antimicrob Agents Chemother 39:484\u2013488","journal-title":"Antimicrob Agents Chemother"},{"key":"19770_CR92","doi-asserted-by":"crossref","unstructured":"De Meijer E, Hammond K (2020)\u00a0Distribution of chemical phenotypes (Chemotypes) in European agricultural hemp (Cannabis sativa L.) cultivars. J Forensic Sci 65(3):715\u2013721","DOI":"10.1111\/1556-4029.14242"},{"issue":"3","key":"19770_CR93","doi-asserted-by":"publisher","first-page":"150","DOI":"10.2471\/BLT.20.251561","volume":"98","author":"V Moorthy","year":"2020","unstructured":"Moorthy V, Restrepo AMH, Preziosi MP, Swaminathan S (2020) Data sharing for novel coronavirus (COVID-19). Bull World Health Organ 98(3):150","journal-title":"Bull World Health Organ"},{"key":"19770_CR94","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.micpath.2017.06.014","volume":"110","author":"MT Moradi","year":"2017","unstructured":"Moradi MT, Karimi A, Rafieian Kopaei M, Fotouhi F (2017) In vitro antiviral effects of Peganum harmala seed extract and its total alkaloids against Influenza virus. Microb Pathog 110:42\u201349","journal-title":"Microb Pathog"},{"key":"19770_CR95","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1038\/ncomms1327","volume":"2","author":"A Nakagawa","year":"2011","unstructured":"Nakagawa A, Minami H, Kim JS, Koyanagi T, Katayama T, Sato F, Kumagai H (2011) A bacterial platform for fermentative production of plant alkaloids. Nat Commun 2:326","journal-title":"Nat Commun"},{"key":"19770_CR96","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1002\/cbdv.200800290","volume":"7","author":"SL Oliveira","year":"2010","unstructured":"Oliveira SL, da Silva MS, Tavares JF, Sena-Filho JG, Lucena HFS, Romero MAV, Barbosa-Filho JM (2010) Alkaloids from Erythroxylum genus: distribution and compilation of 13C-NMR spectral data. Chem Biodivers 7:302\u2013326","journal-title":"Chem. Biodivers."},{"key":"19770_CR97","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1016\/j.jid.2019.11.027","volume":"140","author":"KM Page","year":"2020","unstructured":"Page KM, Suarez-Farinas M, Suprun M, Zhang W, Garcet S, Fuentes-Duculan J, Li X, Scaramozza M, Kieras E, Banfield C (2020) Molecular and cellular responses to the TYK2\/JAK1 inhibitor PF-06700841 reveal reduction of skin in-flammation in plaque psoriasis. J Investig Dermatol 140:1546-1555.e4","journal-title":"J Investig Dermatol"},{"key":"19770_CR98","first-page":"1","volume":"2","author":"SW Page","year":"2008","unstructured":"Page SW, Maddison JE (2008) Principles of clinical pharmacology. Small Animal Clinical Pharmacology 2:1\u201326","journal-title":"Small Animal Clinical Pharmacology"},{"key":"19770_CR99","doi-asserted-by":"publisher","first-page":"100345","DOI":"10.1016\/j.imu.2020.100345","volume":"19","author":"KA Peele","year":"2020","unstructured":"Peele KA, Chandrasai P, Srihansa T, Krupanidhi S, Sai AV, Babu DJ, Indira M, Reddy AR, Venkateswarulu T (2020) Molecular docking and dynamic simulations for antiviral compounds against SARS-CoV-2: a computational study. Inform Med Unlocked 19:100345","journal-title":"Inform. Med. Unlocked"},{"key":"19770_CR100","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1016\/j.jhep.2012.07.006","volume":"57","author":"LV Pham","year":"2012","unstructured":"Pham LV, Ngo HTT, Lim YS (2012) Hwang, S.B. Hepatitis C virus non-structural 5B protein interacts with cyclin A2 and regulates viral propagation. J Hepatol 57:960\u2013966","journal-title":"J Hepatol"},{"issue":"4","key":"19770_CR101","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.drudis.2020.01.015","volume":"25","author":"T Pillaiyar","year":"2020","unstructured":"Pillaiyar T, Meenakshisundaram S, Manickam M (2020) Recent discovery and development of inhibitors targeting coronaviruses. Drug Discov Today 25(4):668\u2013688","journal-title":"Drug Discovery Today"},{"key":"19770_CR102","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1186\/1743-422X-6-197","volume":"6","author":"S Pleschka","year":"2009","unstructured":"Pleschka S, Stein M, Schoop R (2009) Hudson JB (2009) Anti-viral properties and mode of action of standardized Echinacea purpurea extract against highly pathogenic avian influenza virus (H5N1, H7N7) and Swine-Origin H1N1 (S-OIV). Virol J 6:197","journal-title":"Virol J"},{"key":"19770_CR103","doi-asserted-by":"publisher","first-page":"109721","DOI":"10.1016\/j.cellsig.2020.109721","volume":"74","author":"R Poduri","year":"2020","unstructured":"Poduri R, Joshi G, Jagadeesh G (2020) Drugs targeting various stages of the SARS-CoV-2 life cycle: exploring promising drugs for the treatment of Covid-19. Cell Signal 74:109721","journal-title":"Cell. Signal."},{"issue":"4","key":"19770_CR104","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.jpha.2020.03.009","volume":"10","author":"MT Qamar","year":"2020","unstructured":"Qamar MT, Alqahtani SM, Alamri MA, Chen L-L (2020) Structural basis of SARS-CoV-2 3CLpro and anti-COVID-19 drug discovery from medicinal plants. J Pharm Anal 10(4):313\u2013319","journal-title":"J Pharm Anal"},{"key":"19770_CR105","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1002\/(SICI)1098-1128(199811)18:6<375::AID-MED2>3.0.CO;2-8","volume":"18","author":"G Qin","year":"1998","unstructured":"Qin G, Xu R (1998) Recent advances on bioactive natural products from Chinese medicinal plants. Med Res Rev 18:375\u2013382","journal-title":"Med Res Rev"},{"issue":"4","key":"19770_CR106","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1172\/JCI1422","volume":"101","author":"S Qin","year":"1998","unstructured":"Qin S, Rottman JB, Myers P, Kassam N, Weinblatt M, Loetscher M, Mackay CR (1998) The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions. J Clin Investig 101(4):746\u2013754","journal-title":"J Clin Investig"},{"key":"19770_CR107","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.phytochem.2019.05.009","volume":"164","author":"KA Rea","year":"2019","unstructured":"Rea KA, Casaretto JA, Al-Abdul-Wahid MS, Sukumaran A, Geddes-McAlister J, Rothstein SJ, Akhtar TA (2019) Biosynthesis of cannflavins A and B from Cannabis sativa L. Phytochemistry 164:162\u2013171","journal-title":"Phytochemistry"},{"key":"19770_CR108","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1002\/bit.22004","volume":"101","author":"L\u00f3pez-P\u00e9rez PM Ricardo-da-Silva","year":"2008","unstructured":"Ricardo-da-Silva L\u00f3pez-P\u00e9rez PM, Elvira C, Mano JF, Rom\u00e1n JS, Reis RL (2008) Poly (Nisopropylacrylamide) surface-grafted chitosan membranes as a new substrate for cell sheet engineering and manipulation. Biotech Bioeng 101:1321\u20131331","journal-title":"Biotech Bioeng"},{"key":"19770_CR109","doi-asserted-by":"crossref","unstructured":"Richins RD, Rodriguez-Uribe L, Lowe K, Ferral R, Connell O, M A, (2018) Accumulation of bioactive metabolites in cultivated medical Cannabis. PLoS ONE 13:e0201119","DOI":"10.1371\/journal.pone.0201119"},{"key":"19770_CR110","doi-asserted-by":"publisher","first-page":"45","DOI":"10.21101\/cejph.a4578","volume":"26","author":"D Rogowska-Szadkowska","year":"2018","unstructured":"Rogowska-Szadkowska D, Strumi\u0142o J, Chlabicz S (2018) Is medical marijuana legalisation possible in Poland? Cent Eur J Public Health 26:45","journal-title":"Cent Eur J Public Health"},{"issue":"17","key":"19770_CR111","first-page":"9889","volume":"6","author":"X Rui","year":"2014","unstructured":"Rui X, Tan H, Yan Q (2014) Nanostructured metalsulfides for energy storage. Nanoscale 6(17):9889\u20139924","journal-title":"Nanostructured metalsulfides for energy storage. Nanoscale"},{"key":"19770_CR112","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1055\/s-0032-1328705","volume":"79","author":"C Rui","year":"2013","unstructured":"Rui C, Yuxiang L, Ning J, Ningtian M, Qingluan Z, Yinju H, Ru Z, Lin M, Tao S, Jianqiang Y (2013) Anti-apoptotic and neuroprotective effects of oxysophoridine on cerebral ischemia both in vivo and in vitro. Planta Med 79:916\u2013923","journal-title":"Planta Med"},{"key":"19770_CR113","doi-asserted-by":"publisher","first-page":"2272","DOI":"10.3390\/molecules24122272","volume":"24","author":"B Salehi","year":"2019","unstructured":"Salehi B, Sharopov F, Tumer TB, Ozleyen A, Rodr\u00edguez-P\u00e9rez C, Ezzat SM, Azzini E, Hosseinabadi T, Butnariu M, Sarac I (2019) Symphytum species: a comprehensive review on chemical composition, food applications and phytopharmacology. Molecules 24:2272","journal-title":"Molecules"},{"key":"19770_CR114","doi-asserted-by":"crossref","unstructured":"Sep\u00falveda L, Ascacio A, Rodr\u00edguez-Herrera R, Aguilera-Carb\u03cc A, Aguilar CN (1999) Processing of cellular ceramics by foaming and in situ polymerisation of organic monomers.\u00a0J Eur Ceram Soc 19:2059\u20132066","DOI":"10.1016\/S0955-2219(99)00024-2"},{"issue":"S2","key":"19770_CR115","doi-asserted-by":"publisher","first-page":"S310","DOI":"10.1002\/mnfr.200900039","volume":"53","author":"J Serrano","year":"2009","unstructured":"Serrano J, Puupponen-Pimi\u00e4 R, Dauer A, Aura AM, Saura Calixto F (2009) Tannins: current knowledge of food sources, intake, bioavailability and biological effects. Mol Nutr Food Res 53(S2):S310\u2013S329","journal-title":"Mol Nutr Food Res"},{"key":"19770_CR116","first-page":"1281","volume":"5","author":"R Shahni","year":"2013","unstructured":"Shahni R, Handique PJ (2013) Antibacterial properties of leaf extracts of Strobilanthes cusia (Nees) Kuntze, a rare ethno-medicinal plant of Manipur. India Int J Pharmtech Res 5:1281\u20131285","journal-title":"India Int J Pharmtech Res"},{"key":"19770_CR117","doi-asserted-by":"publisher","first-page":"e00023","DOI":"10.1128\/JVI.00023-19","volume":"93","author":"L Shen","year":"2019","unstructured":"Shen L, Niu J, Wang C, Huang B, Wang W, Zhu N, Cen S (2019) High-throughput screening and identification of potent broad-spectrum inhibitors of coronaviruses. J Virol 93:e00023-e19","journal-title":"J Virol"},{"key":"19770_CR118","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1016\/S0031-9422(00)84939-0","volume":"23","author":"Y Shoyama","year":"1984","unstructured":"Shoyama Y, Hirano H (1984) Nishioka I (1984) Biosynthesis of propyl cannabinoid acid and its biosynthetic relationship with pentyl and methyl cannabinoid acids. Phytochemistry 23:1909\u20131912","journal-title":"Phytochemistry"},{"key":"19770_CR119","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.mrgentox.2016.10.001","volume":"810","author":"RM Silva","year":"2016","unstructured":"Silva RM, Pereira LD, V\u00e9ras JH, Do Vale CR, Chen-Chen L, Da Costa SS (2016) Protective effect and induction of DNA repair by Myrciaria cauliflora seed extract and pedunculagin on cyclophosphamide -induced genotoxicity. Mutation Res\/Gen Toxicol Environ Mutagenesis 810:40\u201347","journal-title":"Mutation Res\/Gen Toxicol Environ Mutagenesis"},{"key":"19770_CR120","unstructured":"Silva Ant\u00f4nio AMd (2020) On the possibility of interrupting the coronavirus (COVID-19) epidemic based on the best available scientific evidence. Revista Brasileira de Epidemiologia 23:e200021"},{"key":"19770_CR121","first-page":"11","volume":"18","author":"M Simre","year":"2018","unstructured":"Simre M, Tack J (2018) Analysis of risk factors and prevention strategies for functional delayed gastric emptying in 1243 patients with distal gastric cancer. World J Surg Oncol 18:11\u201310","journal-title":"World J Surg Oncol"},{"key":"19770_CR122","doi-asserted-by":"publisher","first-page":"39767","DOI":"10.1074\/jbc.M403693200","volume":"279","author":"S Sirikantaramas","year":"2004","unstructured":"Sirikantaramas S, Morimoto S, Shoyama Y, Ishikawa Y, Wada Y, Shoyama Y, Taura F (2004) The gene controlling marijuana psychoactivity: molecular cloning and heterologous expression of D1-tetrahydrocannabinolic acid synthase from Cannabis Sativa L. J Biol Chem 279:39767\u201339774","journal-title":"J Biol Chem"},{"issue":"11","key":"19770_CR123","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1111\/bph.13630","volume":"174","author":"A Smeriglio","year":"2017","unstructured":"Smeriglio A, Barreca D, Bellocco E, Trombetta D (2017) Proanthocyanidins and hydrolysable tannins: occurrence, dietary intake and pharmacological effects. British J Pharmacol 174(11):1244\u20131262","journal-title":"British J Pharmacol"},{"key":"19770_CR124","doi-asserted-by":"crossref","unstructured":"Smeriglio A, Trombetta D, Lagan\u00e0 G (2020) Colored phytonutrients: role and applications in the functional foods of anthocyanins. In Phytonutrients in Food. Woodhead Publishing, pp 177\u2013195","DOI":"10.1016\/B978-0-12-815354-3.00011-3"},{"key":"19770_CR125","first-page":"1223","volume":"17","author":"K Solymosi","year":"2017","unstructured":"Solymosi K, Kofalvi A (2017) Cannabis: a treasure trove or pandora\u2019s box? Mini Rev Med Chem 17:1223\u20131291","journal-title":"Med Chem"},{"key":"19770_CR126","first-page":"128","volume":"11","author":"K Spelman","year":"2006","unstructured":"Spelman K, Burns J, Nichols D, Winters N, Ottersberg S, Tenborg M (2006) Modulation of cytokine expression by traditional medicines: are view of herbal immunomodulators. Altern Med Rev 11:128\u2013150","journal-title":"Altern Med Rev"},{"issue":"53","key":"19770_CR127","doi-asserted-by":"publisher","first-page":"171","DOI":"10.3961\/jpmph.20.094","volume":"2020","author":"S Tasnim","year":"2020","unstructured":"Tasnim S, Hossain MM, Mazunder H (2020) J Prev Med Public Health 2020(53):171\u2013174","journal-title":"J Prev Med Public Health"},{"key":"19770_CR128","doi-asserted-by":"publisher","first-page":"9766","DOI":"10.1021\/ja00143a024","volume":"117","author":"F Taura","year":"1995","unstructured":"Taura F, Morimoto S, Shoyama Y, Mechoulam R (1995) First direct evidence for the mechanism of. DELTA. 1-tetrahydrocannabinolic acid biosynthesis. J Am Chem Soc 117:9766\u20139767","journal-title":"J Am Chem Soc"},{"key":"19770_CR129","doi-asserted-by":"publisher","first-page":"2929","DOI":"10.1016\/j.febslet.2007.05.043","volume":"581","author":"F Taura","year":"2007","unstructured":"Taura F, Sirikantaramas S, Shoyama Y, Yoshikai K, Shoyama Y, Morimoto S (2007) Cannabidiolic-acid synthase, the chemotype-determining enzyme in the fiber-type Cannabis sativa. FEBS Lett 581:2929\u20132934","journal-title":"FEBS Lett"},{"key":"19770_CR130","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.febslet.2009.05.024","volume":"583","author":"F Taura","year":"2009","unstructured":"Taura F, Tanaka S, Taguchi C, Fukamizu T, Tanaka H, Shoyama Y, Morimoto S (2009) Characterization of olivetol synthase, a polyketide synthase reputative involved in cannabinoid biosynthetic pathway. Febslett 583:22","journal-title":"Febslett"},{"issue":"3","key":"19770_CR131","first-page":"197","volume":"44","author":"R Thanacoody","year":"2016","unstructured":"Thanacoody R (2016) Quinine and chloroquine. Medicine 44(3):197\u2013198","journal-title":"Quinine and chloroquine. Medicine"},{"key":"19770_CR132","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1097\/MOL.0000000000000552","volume":"29","author":"PL Thompson","year":"2018","unstructured":"Thompson PL, Nidorf SM (2018) Colchicine: an affordable anti-inflammatory agent for atherosclerosis. Curr Opin Lipidol 29:467\u2013473","journal-title":"Curr Opin Lipidol"},{"key":"19770_CR133","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1002\/j.1537-2197.1978.tb06177.x","volume":"65","author":"JC Turner","year":"1978","unstructured":"Turner JC, Hemphill JK, Mahlberg PG (1978) Quantitative determination of cannabinoids in individual glandular trichomes of Cannabis sativa L. (Cannabaceae). Am J Bot 65:1103\u20131106","journal-title":"Am. J. Bot."},{"issue":"22","key":"19770_CR134","doi-asserted-by":"crossref","first-page":"14422","DOI":"10.1103\/PhysRevB.57.14422","volume":"57","author":"M Uozaki","year":"1998","unstructured":"Uozaki M, Yamasaki H, Katsuyama Y, Higuchi M, Higuti T, Koyama AH (1998) 2 D NMR in \u03b1\u2212(h 8\u2212 B E D T\u2212 T T F) 2 ND 4 Hg (SCN) 4. Phys Rev B 57(22):14422","journal-title":"Phys Rev B"},{"key":"19770_CR135","doi-asserted-by":"crossref","unstructured":"Ushio Y, Fang T, Okuda T, Abe H (2012)\u00a0\u00a0L type Ca2+ channel blockers prevent\u00a0 oxaliplatin-induced cold hyperalgesia and TRPM8 overexpression in rats. Molecular Pain 8:1744\u20138069","DOI":"10.1186\/1744-8069-8-7"},{"key":"19770_CR136","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1056\/NEJMc2004973","volume":"382","author":"N Van Doremalen","year":"2020","unstructured":"Van Doremalen N, Bushmaker T, Morris DH, Holbrook MG, Gamble A, Williamson BN, Tamin A, Harcourt JL, Thornburg NJ, Gerber SI (2020) Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1. N Engl J Med\u00a0 382:1564\u20131567","journal-title":"N. Engl. J. Med."},{"key":"19770_CR137","doi-asserted-by":"publisher","first-page":"9743","DOI":"10.1128\/JVI.01382-16","volume":"90","author":"FS Varghese","year":"2016","unstructured":"Varghese FS, Thaa B, Amrun SN, Simarmata D, Rausalu K, Nyman TA, Merits A, McInerney GM, Ng LFP, Ahola T (2016) The antiviral alkaloid Berberine reduces Chikungunya virus-induced mitogen-activated protein kinase signaling. J Virol\u00a0 90:9743\u20139757","journal-title":"J. Virol."},{"key":"19770_CR138","doi-asserted-by":"publisher","first-page":"561334","DOI":"10.3389\/fphar.2020.561334","volume":"11","author":"S Verma","year":"2020","unstructured":"Verma S, Twilley D, Esmear T, Oosthuizen CB, Reid AM, Nel M, Lall N (2020) Anti-SARS-CoV natural products with the potential to inhibit SARS-CoV-2 (COVID-19). Front Pharmacol 11:561334","journal-title":"Front. Pharmacol."},{"key":"19770_CR139","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1038\/nchembio862","volume":"3","author":"T Voets","year":"2007","unstructured":"Voets T, Owsianik G, Janssens A, Talavera K, Nilius B (2007) TRPM8 voltage sensor mutants reveal a mechanism for integrating thermal and chemical stimuli. Nat Chem Biol 3:174","journal-title":"Nat Chem Biol"},{"key":"19770_CR140","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.ejmech.2019.02.076","volume":"169","author":"T Wang","year":"2019","unstructured":"Wang T, Liu X, Guan J, Ge S, Wu MB, Lin J, Yang L (2019) Advancement of multi-target drug discoveries and promising applications in the field of Alzheimer\u2019s disease. Eur J Med Chem 169:200\u2013223","journal-title":"Eur J Med Chem"},{"key":"19770_CR141","doi-asserted-by":"publisher","first-page":"5072","DOI":"10.1021\/jm960603e","volume":"39","author":"SE Webber","year":"1996","unstructured":"Webber SE, Tikhe J, Worland ST, Fuhrman SA, Hendrickson TF, Matthews DA, Ferre RA (1996) Design, synthesis, and evaluation of nonpeptidic inhibitors of human rhinovirus 3C protease. J Med Chem 39:5072\u20135082","journal-title":"J Med Chem"},{"key":"19770_CR142","first-page":"1","volume":"81","author":"C Weber","year":"2019","unstructured":"Weber C, Opatz T (2019) Bisbenzylisoquinoline alkaloids. Alkaloids. Chem Biol 81:1\u2013114","journal-title":"Chem Biol"},{"key":"19770_CR143","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.phanu.2014.05.001","volume":"2","author":"O Werz","year":"2014","unstructured":"Werz O, Seegers J, Schaible AM, Weinigel C, Barz D, Koeberle A, Allegrone G, Pollastro F, Zampieri L, Grassi G (2014) Cannflavins from hemp sprouts, novel cannabinoid-free hemp food product, target microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase. Pharma Nutrition 2:53\u201360","journal-title":"Pharma Nutrition"},{"key":"19770_CR144","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.1080\/14786419.2017.1416385","volume":"33","author":"W Xu","year":"2019","unstructured":"Xu W, Zhang M, Liu H, Wei K, He M, Li X, Hu D, Yang S, Zheng Y (2019) Antiviral activity of aconite alkaloids from Aconitum carmichaelii Debx. Nat Prod Res 33:1486\u20131490","journal-title":"Nat Prod Res"},{"issue":"23","key":"19770_CR145","doi-asserted-by":"publisher","first-page":"13190","DOI":"10.1073\/pnas.1835675100","volume":"100","author":"H Yang","year":"2003","unstructured":"Yang H, Yang M, Ding Y, Liu Y, Lou Z, Zhou Z, Rao Z (2003) The crystal structures of severe acute respiratory syndrome virus main protease andits complex with an inhibitor. Proc Natl Acad Sci 100(23):13190\u201313195","journal-title":"Proc Natl Acad Sci"},{"key":"19770_CR146","doi-asserted-by":"publisher","first-page":"4573","DOI":"10.2174\/138161206779010369","volume":"12","author":"H Yang","year":"2006","unstructured":"Yang H, Bartlam M, Rao Z (2006) Drug design targeting the main protease, the Achilles heel of coronaviruses. Curr Pharm Des 12:4573\u20134590","journal-title":"Curr Pharm Des"},{"key":"19770_CR147","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.antiviral.2010.08.009","volume":"88","author":"CW Yang","year":"2010","unstructured":"Yang CW, Lee YZ, Kang IJ, Barnard DL, Jan JT, Lin D, Lee SJ (2010) Identification of phenanthroindolizines and phenanthroquinolizidines as novel potent anti-coronaviral agents for porcine enteropathogenic coronavirus transmissible gastroenteritis virus and human severe acute respiratory syndrome coronavirus. Antiviral Res 88:160\u2013168","journal-title":"Antiviral Res"},{"key":"19770_CR148","first-page":"1","volume":"7","author":"C Yang","year":"2017","unstructured":"Yang C, Lee W, Hsu YZ, Shih HY, Chao YS, Chang HY, Lee SJ (2017) Targeting coronaviral replication and cellular JAK2 mediated dominant NF-\u03baB activation for comprehensive and ultimate inhibition of coronaviral activity. Sci Reports 7:1\u201313","journal-title":"Sci Reports"},{"issue":"1\u20132","key":"19770_CR149","first-page":"211","volume":"289","author":"H Yang","year":"2004","unstructured":"Yang H, Li J, Wang H, Mason JM, Levine J, Yu M, Ulloa L, Czura CJ, Tracey KJ (2004) Recombinant HMGB1 with cytokine-stimulating activity. J Immunol Methods 289(1\u20132):211\u2013223","journal-title":"J Immunol Methods"},{"key":"19770_CR150","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/s11655-012-1001-6","volume":"18","author":"X Yao","year":"2012","unstructured":"Yao X, Zhang Y, Long W, Liu P (2012) Oxysophoridine suppresses the growth of hepatocellular carcinoma in mice. In Vivo and cDNA microarray studies. Chin J Integr Med 18:209\u2013213","journal-title":"Chin J Integr Med"},{"key":"19770_CR151","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1126\/science.aan4325","volume":"359","author":"Y Yin","year":"2018","unstructured":"Yin Y, Wu M, Zubcevic L, Borschel WF, Lander GC, Lee S (2018) Structure of the cold- and menthol-sensing ion channel TRPM8. Science 359:237\u2013241","journal-title":"Science"},{"issue":"736","key":"19770_CR152","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/nature10496","volume":"478","author":"K Yoshida","year":"2011","unstructured":"Yoshida K, Sanada M, Shiraishi Y, Nowak D, Nagata Y, Yamamoto R, Sato Y et al (2011) Frequent pathway mutations of splicing machinery in myelodysplasia. Nature 478(736):64\u201369","journal-title":"Nature"},{"key":"19770_CR153","doi-asserted-by":"publisher","first-page":"13042","DOI":"10.3390\/molecules190913042","volume":"19","author":"X Yu","year":"2014","unstructured":"Yu X, Gao X, Zhu Z, Cao Y, Zhang Q, Tu P, Chai X (2014a) Alkaloids from the Tribe Bocconieae (Papaveraceae): a chemical and biological review. Molecules 19:13042\u201313060","journal-title":"Molecules"},{"issue":"7","key":"19770_CR154","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1002\/adma.201304148","volume":"26","author":"X Yu","year":"2014","unstructured":"Yu X, Lu B, Xu Z (2014b) Super long-life supercapacitors based on the construction of nanohoneycomb-like strongly coupled CoMoO4\u20133D graphene hybrid electrodes. Advanced materials 26(7):1044\u20131051","journal-title":"Advanced materials"},{"issue":"19","key":"19770_CR155","first-page":"9026","volume":"102","author":"G Zeng","year":"2011","unstructured":"Zeng G, Zhang J, Chen Y, Yu Z, Yu M, Li H, Liu Z, Chen M, Lu L, Hu C (2011) Relative contributions of archaea and bacteria to microbial ammonia oxidation differ under different conditions during agricultural waste composting. J Immunol Methods 102(19):9026\u20139032","journal-title":"J Immunol Methods"},{"key":"19770_CR156","unstructured":"Zhang H, Cisse M, Dauphin YN, Lopez-Paz D (2017) mixup: Beyond empirical risk minimization. arXiv preprint arXiv:1710.09412"},{"key":"19770_CR157","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1080\/22221751.2020.1772676","volume":"9","author":"YN Zhang","year":"2020","unstructured":"Zhang YN, Zhang QY, Li XD, Xiong J, Xiao SQ, Wang Z, Zhang ZR, Deng CL, Yang XL (2020) Wei H P (2020) Gemcitabine, lycorine and oxysophoridine inhibit novel coronavirus (SARS-CoV-2) in cell culture. Emerg Microbes Infect 9:1170\u20131173","journal-title":"Emerg Microbes Infect"},{"key":"19770_CR158","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/s41586-020-2012-7","volume":"579","author":"P Zhou","year":"2020","unstructured":"Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, Hao-Rusi S, Zhu Y, Li B, Huang CL (2020) A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 579:270\u2013273","journal-title":"Nature."},{"issue":"2","key":"19770_CR159","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.neuron.2005.04.001","volume":"46","author":"Y Zuo","year":"2005","unstructured":"Zuo Y, Lin A, Chang P, Gan WB (2005) Development of long-term dendritic spine stability in diverse regions of cerebral cortex. Neuron 46(2):181\u2013189","journal-title":"Neuron"},{"key":"19770_CR160","unstructured":"Zhu Y, Papandreou G, Schroff F, Adam H (2018) Encoder-decoder with atrous separable convolution for semantic image segmentation. In Proceedings of the European conference on computer vision (ECCV), pp. 801\u2013818"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-022-19770-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11356-022-19770-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-022-19770-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T17:24:44Z","timestamp":1668273884000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11356-022-19770-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,1]]},"references-count":160,"journal-issue":{"issue":"28","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["19770"],"URL":"https:\/\/doi.org\/10.1007\/s11356-022-19770-2","relation":{},"ISSN":["0944-1344","1614-7499"],"issn-type":[{"value":"0944-1344","type":"print"},{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,1]]},"assertion":[{"value":"1 September 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 March 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All the authors have approved and reviewed the current manuscript for final publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}