{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T08:27:17Z","timestamp":1777624037985,"version":"3.51.4"},"reference-count":81,"publisher":"Springer Science and Business Media LLC","issue":"52","license":[{"start":{"date-parts":[[2022,6,11]],"date-time":"2022-06-11T00:00:00Z","timestamp":1654905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,6,11]],"date-time":"2022-06-11T00:00:00Z","timestamp":1654905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1007\/s11356-022-21027-x","type":"journal-article","created":{"date-parts":[[2022,6,11]],"date-time":"2022-06-11T03:31:47Z","timestamp":1654918307000},"page":"78396-78413","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Impacts of engineered iron nanoparticles on oxidative stress, fatty acid composition, and histo-architecture of the smooth scallop Flexopecten glaber"],"prefix":"10.1007","volume":"29","author":[{"given":"Imen","family":"Rabeh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaoula","family":"Telahigue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3869-8876","authenticated-orcid":false,"given":"Tarek","family":"Hajji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zied","family":"Mdaini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salwa","family":"Nechi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emna","family":"Chelbi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u2019hamed","family":"El Cafsi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lazhar","family":"Mhadhbi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,6,11]]},"reference":[{"key":"21027_CR1","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/J.CEJ.2015.10.105","volume":"286","author":"A Adeleye","year":"2016","unstructured":"Adeleye A, Conway JR, Garner KL, Huang Y, Su Y, Keller A (2016) Engineered nanomaterials for water treatment and remediation: costs, benefits, and applicability. Chem Eng J 286:640\u2013662. https:\/\/doi.org\/10.1016\/J.CEJ.2015.10.105","journal-title":"Chem Eng J"},{"key":"21027_CR2","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","volume":"105","author":"H Aebi","year":"1984","unstructured":"Aebi H (1984) Catalase in vitro. Methods Enzymol 105:121\u2013126. https:\/\/doi.org\/10.1016\/S0076-6879(84)05016-3","journal-title":"Methods Enzymol"},{"issue":"24","key":"21027_CR3","doi-asserted-by":"publisher","first-page":"14480","DOI":"10.1021\/acs.est.8b05266","volume":"52","author":"M Al-Sid-Cheikh","year":"2013","unstructured":"Al-Sid-Cheikh M, Rowland SJ, Stevenson K, Rouleau C, Henry TB, Thompson RC (2013) Uptake, whole-body distribution, and depuration of nanoplastics by the scallop Pecten maximus at environmentally realistic concentrations. Environ Sci Technol 52(24):14480\u201314486. https:\/\/doi.org\/10.1021\/acs.est.8b05266","journal-title":"Environ Sci Technol"},{"key":"21027_CR4","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/360438","volume":"2014","author":"A Ayala","year":"2014","unstructured":"Ayala A, Munoz MF, Arguelles S (2014) Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. Oxid Med Cell Longev 2014:360438. https:\/\/doi.org\/10.1155\/2014\/360438","journal-title":"Oxid Med Cell Longev"},{"key":"21027_CR5","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.aquatox.2016.05.005","volume":"177","author":"M Ates","year":"2016","unstructured":"Ates M, Demir V, Arslan Z, Kaya H, Y\u0131lmaz S, Camas M (2016) Chronic exposure of tilapia (Oreochromis niloticus) to iron oxide nanoparticles: effects of particle morphology on accumulation, elimination, hematology and immune responses. Aquat Toxicol 177:22\u201332. https:\/\/doi.org\/10.1016\/j.aquatox.2016.05.005","journal-title":"Aquat Toxicol"},{"issue":"1","key":"21027_CR6","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/0003-2697(71)90370-8","volume":"44","author":"C Beauchamp","year":"1971","unstructured":"Beauchamp C, Fridovich I (1971) Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. Anal Biochem 44(1):276\u2013287. https:\/\/doi.org\/10.1016\/0003-2697(71)90370-8","journal-title":"Anal Biochem"},{"key":"21027_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2021.131044","volume":"282","author":"M Bibi","year":"2021","unstructured":"Bibi M, Zhu X, Munir M, Angelidaki I (2021) Bioavailability and effect of \u03b1-Fe2O3 nanoparticles on growth, fatty acid composition and morphological indices of Chlorella vulgaris. Chemosphere 282:131044. https:\/\/doi.org\/10.1016\/j.chemosphere.2021.131044","journal-title":"Chemosphere"},{"key":"21027_CR8","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.marenvres.2011.05.004","volume":"72","author":"JP Bignell","year":"2011","unstructured":"Bignell JP, Stentiford G, Taylor N, Lyons B (2011) Histopathology of mussels (Mytilus sp.) from the Tamar estuary. UK. Mar Environ Res 72:25\u201332. https:\/\/doi.org\/10.1016\/j.marenvres.2011.05.004","journal-title":"UK. Mar Environ Res"},{"issue":"2","key":"21027_CR9","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1080\/01480545.2017.1329317","volume":"41","author":"Y Bouallegui","year":"2018","unstructured":"Bouallegui Y, Ben Younes R, Turki F, Mezni A, Oueslati R (2018) Effect of exposure time, particle size and uptake pathways in immune cell lysosomal cytotoxicity of mussels exposed to silver nanoparticles. Drug Chem Toxicol 41(2):169\u2013174. https:\/\/doi.org\/10.1080\/01480545.2017.1329317","journal-title":"Drug Chem Toxicol"},{"key":"21027_CR10","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.marenvres.2013.12.009","volume":"95","author":"M Brenner","year":"2013","unstructured":"Brenner M, Broeg K, Frickenhaus S, Buck B, Koehler A (2013) Multi-biomarker approach using the blue mussel (Mytilus edulis L.) to assess the quality of marine environments: season and habitat-related impacts. Mar Environ Res 95:13\u201327. https:\/\/doi.org\/10.1016\/j.marenvres.2013.12.009","journal-title":"Mar Environ Res"},{"key":"21027_CR11","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.marenvres.2011.06.005","volume":"76","author":"L Canesi","year":"2012","unstructured":"Canesi L, Ciacci C, Fabbri R, Marcomini A, Pojana G, Gallo G (2012) Bivalve molluscs as a unique target group for nanoparticle toxicity. Mar Environ Res 76:16\u201321. https:\/\/doi.org\/10.1016\/j.marenvres.2011.06.005","journal-title":"Mar Environ Res"},{"issue":"2","key":"21027_CR12","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.aquatox.2009.10.017","volume":"96","author":"L Canesi","year":"2010","unstructured":"Canesi L, Ciacci C, Vallotto D, Gallo G, Marcomini A, Pojana G (2010) In vitro effects of suspensions of selected nanoparticles (C60 fullerene, TiO2, SiO2) on Mytilus hemocytes. Aquat Toxicol 96(2):151\u2013158. https:\/\/doi.org\/10.1016\/j.aquatox.2009.10.017","journal-title":"Aquat Toxicol"},{"key":"21027_CR13","first-page":"63","volume":"4","author":"G Cecchi","year":"1985","unstructured":"Cecchi G, Basini S, Castano C (1985) M\u00e9thanolyse rapide des huiles en solvant. Rev Fr Corps Gras 4:63\u2013164","journal-title":"Rev Fr Corps Gras"},{"issue":"15","key":"21027_CR14","doi-asserted-by":"publisher","first-page":"8431e8439","DOI":"10.1021\/es3006783","volume":"46","author":"PJ Chen","year":"2012","unstructured":"Chen PJ, Tan SW, Wu WL (2012) Stabilization or oxidation of nanoscale zerovalent iron at environmentally relevant exposure changes bioavailability and toxicity in medaka fish. Environ. Sci. Technol 46(15):8431e8439","journal-title":"Environ. Sci. Technol"},{"key":"21027_CR15","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1016\/j.rvsc.2012.03.014","volume":"93","author":"G De Vico","year":"2012","unstructured":"De Vico G, Carella F (2012) Morphological features of the inflammatory response in molluscs. Res Vet Sci 93:1109\u20131115","journal-title":"Res Vet Sci"},{"key":"21027_CR16","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/0076-6879(90)86135-I","volume":"186","author":"HH Draper","year":"1990","unstructured":"Draper HH, Hadley M (1990) Malondialdehyde determination as index of lipid peroxidation. Methods Enzymol. 186:421\u2013431. https:\/\/doi.org\/10.1016\/0076-6879(90)86135-I","journal-title":"Methods Enzymol."},{"issue":"1","key":"21027_CR17","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","volume":"82","author":"GL Ellman","year":"1959","unstructured":"Ellman GL (1959) Tissue sulfhydryl groups. Arch Biochem Biophys 82(1):70\u201377. https:\/\/doi.org\/10.1016\/0003-9861(59)90090-6","journal-title":"Arch Biochem Biophys"},{"key":"21027_CR18","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.aquatox.2016.09.005","volume":"180","author":"M Fadhlaoui","year":"2016","unstructured":"Fadhlaoui M, Couture P (2016) Combined effects of temperature and metal exposure on the fatty acid composition of cell membranes, antioxidant enzyme activities and lipid peroxidation in yellow perch (Perca flavescens). Aquat Toxicol 180:45\u201355. https:\/\/doi.org\/10.1016\/j.aquatox.2016.09.005","journal-title":"Aquat Toxicol"},{"key":"21027_CR19","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/j.ecolind.2016.03.044","volume":"67","author":"V Filimonova","year":"2016","unstructured":"Filimonova V, Gon\u00e7alves F, Marques JC, De Troch M, Gon\u00e7alves ANN (2016) Fatty acid profiling as bioindicator of chemical stress in marine organisms: a review. Ecol Indicat 67:657\u2013672. https:\/\/doi.org\/10.1016\/j.ecolind.2016.03.044","journal-title":"Ecol Indicat"},{"key":"21027_CR20","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/S0076-6879(84)05015-1","volume":"105","author":"L Floh\u00e9","year":"1984","unstructured":"Floh\u00e9 L, G\u00fcnzler WA (1984) Assays of glutathione peroxidase. Methods Enzymol 105:114\u2013121. https:\/\/doi.org\/10.1016\/S0076-6879(84)05015-1","journal-title":"Methods Enzymol"},{"key":"21027_CR21","doi-asserted-by":"crossref","unstructured":"Fokina NN, Ruokolainen TR, Nemova NN (2017) Lipid composition modifications in the blue mussels (Mytilus edulis L.) from the White Sea. In (Ed.), Organismal and molecular malacology. IntechOpen. 10.5772\/67811","DOI":"10.5772\/67811"},{"issue":"1","key":"21027_CR22","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","volume":"226","author":"J Folch","year":"1957","unstructured":"Folch J, Lees M, Sloane-Stanley GA (1957) A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226(1):497\u2013509","journal-title":"J Biol Chem"},{"key":"21027_CR23","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.aquatox.2012.03.017","volume":"118-119","author":"T Gomes","year":"2012","unstructured":"Gomes T, Pereira CG, Cardoso C, Pinheiro JP, Cancio I, Bebianno MJ (2012) Accumulation and toxicity of copper oxide nanoparticles in the digestive gland of Mytilus galloprovincialis. Aquat Toxicol 118-119:72\u201379. https:\/\/doi.org\/10.1016\/j.aquatox.2012.03.017","journal-title":"Aquat Toxicol"},{"key":"21027_CR24","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.marenvres.2014.07.004","volume":"101","author":"T Gomes","year":"2014","unstructured":"Gomes T, Pereira CG, Cardoso C, Sousa VS, Teixeira MR, Pinheiro JP, Bebianno MJ (2014) Effects of silver nanoparticles exposure in the mussel Mytilus galloprovincialis. Mar Environ Res 101:208\u2013214. https:\/\/doi.org\/10.1016\/j.marenvres.2014.07.004","journal-title":"Mar Environ Res"},{"issue":"6","key":"21027_CR25","doi-asserted-by":"publisher","first-page":"807","DOI":"10.3109\/17435390.2015.1132348","volume":"10","author":"R Gornati","year":"2016","unstructured":"Gornati R, Longo A, Rossi F, Maisano M, Sabatino G, Mauceri A, Bernardini G, Fasulo S (2016) Effects of titanium dioxide nanoparticle exposure in Mytilus galloprovincialis gills and digestive gland. Nanotoxicology 10(6):807\u2013817. https:\/\/doi.org\/10.3109\/17435390.2015.1132348","journal-title":"Nanotoxicology"},{"key":"21027_CR26","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/S0025-326X(99)00119-8","volume":"39","author":"MA Gregory","year":"1999","unstructured":"Gregory MA, George RC, Marshall DJ, Anadraj A, Mcclurg TP (1999) The effects of mercury exposure on the surface morphology of gill filaments in Perna perna (Mollusca: Bivalvia). Mar Pollut Bull 39:116\u2013121","journal-title":"Mar Pollut Bull"},{"key":"21027_CR27","doi-asserted-by":"publisher","unstructured":"Hao L, Chen L (2012) Oxidative stress responses in different organs of carp (Cyprinus carpio) with exposure to ZnO nanoparticles. Ecotoxicol Environ Saf 80:103-10. 10. doi: https:\/\/doi.org\/10.1016\/j.ecoenv.2012.02.017","DOI":"10.1016\/j.ecoenv.2012.02.017"},{"issue":"5","key":"21027_CR28","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1080\/07388551.2016.1207153","volume":"37","author":"M Hashimoto","year":"2017","unstructured":"Hashimoto M, Hossain S, Al Mamun A, Matsuzaki K, Arai H (2017) Docosahexaenoic acid: one molecule diverse functions. Crit Rev Biotechnol 37(5):579\u2013597. https:\/\/doi.org\/10.1080\/07388551.2016.1207153","journal-title":"Crit Rev Biotechnol"},{"key":"21027_CR29","doi-asserted-by":"crossref","unstructured":"Jollow DJ, Mitchell JR, Zampaglione N, Gillette JR (1974) Bromobenzene induced liver necrosis. Protective role of glutathione and evidence for 3, 4- bromobenzene oxide as the hepatotoxic metabolite. Pharmacology 11 (3):151-169. 10.1159\/000136485","DOI":"10.1159\/000136485"},{"key":"21027_CR30","doi-asserted-by":"publisher","first-page":"3145","DOI":"10.3390\/ijms13033145","volume":"13","author":"M Jozefczak","year":"2012","unstructured":"Jozefczak M, Remans T, Vangronsveld J, Cuypers A (2012) Glutathione is a key player in metal-induced oxidative stress defenses. Int J Mol Sci 13:3145\u20133175. https:\/\/doi.org\/10.3390\/ijms13033145","journal-title":"Int J Mol Sci"},{"key":"21027_CR31","doi-asserted-by":"publisher","first-page":"4642","DOI":"10.3390\/ijms22094642","volume":"22","author":"CA Juan","year":"2021","unstructured":"Juan CA, P\u00e9rez de la Lastra JM, Plou FJ, P\u00e9rez-Lebe\u00f1a E (2021) The chemistry of reactive oxygen species (ROS) revisited: outlining their role in biological macromolecules (DNA, lipids and proteins) and induced pathologies. Int J Mol Sci 22:4642. https:\/\/doi.org\/10.3390\/ijms22094642","journal-title":"Int J Mol Sci"},{"key":"21027_CR32","doi-asserted-by":"publisher","first-page":"3490","DOI":"10.1016\/j.envpol.2010.03.025","volume":"158","author":"E Kadar","year":"2010","unstructured":"Kadar E, Simmance F, Martin O, Voulvoulis N, Widdicombe S, Mitovc S, Lead JR, Readman JW (2010) The influence of engineered Fe2O3 nanoparticles and soluble (FeCl3) iron on the developmental toxicity caused by CO2-induced seawater acidification. Environ Pollut 158:3490\u20133497. https:\/\/doi.org\/10.1016\/j.envpol.2010.03.025","journal-title":"Environ Pollut"},{"issue":"1","key":"21027_CR33","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1002\/cbf.1190.\u00a3","volume":"24","author":"R Kayali","year":"2006","unstructured":"Kayali R, Cakatay U, Akcay T, Altug T (2006) Effect of alpha-lipoic acid supplementation on markers of protein oxidation in post-mitotic tissues of ageing rat. Cell Biochem Funct 24(1):79\u201385. https:\/\/doi.org\/10.1002\/cbf.1190.\u00a3","journal-title":"Cell Biochem Funct"},{"issue":"8","key":"21027_CR34","doi-asserted-by":"publisher","first-page":"43983","DOI":"10.1371\/journal.pone.0043983","volume":"7","author":"AA Keller","year":"2012","unstructured":"Keller AA, Garner K, Miller RJ, Lenihan HS (2012) Toxicity of nano-zero valent iron to freshwater and marine organisms. PLoS ONE 7(8):43983. https:\/\/doi.org\/10.1371\/journal.pone.0043983","journal-title":"PLoS ONE"},{"key":"21027_CR35","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.envpol.2017.09.052","volume":"232","author":"C Lei","year":"2018","unstructured":"Lei C, Sun Y, Tsang DCW, Lin D (2018) Environmental transformations and ecological effects of iron-based nanoparticles. Environ Pollut 232:10\u201330. https:\/\/doi.org\/10.1016\/j.envpol.2017.09.052","journal-title":"Environ Pollut"},{"key":"21027_CR36","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.envpol.2016.07.030","volume":"218","author":"C Lei","year":"2016","unstructured":"Lei C, Zhang L, Yang K, Zhu L, Lin D (2016) Toxicity of iron-based nanoparticles to green algae: effects of particle size, crystal phase, oxidation state and environmental aging. Environ Pollut 218:505\u2013512. https:\/\/doi.org\/10.1016\/j.envpol.2016.07.030","journal-title":"Environ Pollut"},{"key":"21027_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2019.134886","volume":"719","author":"C Leite","year":"2020","unstructured":"Leite C, Coppola F, Monteiro R, Russo T, Polese G, Louren\u00e7o MAO, Silva MRF, Ferreira P, Soares AMVM, Freitas R, Pereira E (2020) Biochemical and histopathological impacts of rutile and anatase (TiO2 forms) in Mytilus galloprovincialis. Sci. Total Environ 719:134886. https:\/\/doi.org\/10.1016\/j.scitotenv.2019.134886","journal-title":"Sci. Total Environ"},{"issue":"3","key":"21027_CR38","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1016\/j.ecoenv.2008.09.027","volume":"72","author":"H Li","year":"2009","unstructured":"Li H, Zhou Q, Wu Y, Fu J, Wang T, Jiang G (2009) Effects of waterborne nano-iron on medaka (Oryzias latipes): antioxidant enzymatic activity, lipid peroxidation and histopathology. Ecotoxicol Environ Saf 72(3):684\u2013692. https:\/\/doi.org\/10.1016\/j.ecoenv.2008.09.027","journal-title":"Ecotoxicol Environ Saf"},{"issue":"4","key":"21027_CR39","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1080\/10408430601057611","volume":"31","author":"XQ Li","year":"2006","unstructured":"Li XQ, Elliott DW, Zhang WX (2006) Zero-valent iron nanoparticles for abatement of environmental pollutants: materials and engineering aspects. Crit Rev Solid State Mater Sci 31(4):111\u2013122. https:\/\/doi.org\/10.1080\/10408430601057611","journal-title":"Crit Rev Solid State Mater Sci"},{"issue":"10","key":"21027_CR40","doi-asserted-by":"publisher","first-page":"4638","DOI":"10.1021\/la060057k","volume":"22","author":"XQ Li","year":"2006","unstructured":"Li XQ, Zhang WX (2006) Iron nanoparticles: the core\u2013shell structure and unique properties for Ni (II) sequestration. Langmuir 22(10):4638\u20134642. https:\/\/doi.org\/10.1021\/la060057k","journal-title":"Langmuir"},{"key":"21027_CR41","doi-asserted-by":"publisher","unstructured":"Liu L, Luan L, Luo X, Wang X, Lu H, Li Y, Wen L, Li F, Zhao J (2021) Functionalized polystyrene nanoplastics induced energy homeostasis imbalance and immunomodulation dysfunction of marine clams (Meretrix meretrix) at environmentally relevant concentrations. Environ Sci Nano 8. https:\/\/doi.org\/10.1039\/D1EN00212K","DOI":"10.1039\/D1EN00212K"},{"issue":"1","key":"21027_CR42","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193(1):265\u2013275","journal-title":"J Biol Chem"},{"key":"21027_CR43","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1111\/j.1530-9290.2008.00041.x","volume":"12","author":"T Maccormack","year":"2008","unstructured":"Maccormack T, Goss G (2008) Identifying and predicting biological risks associated with manufactured nanoparticles in aquatic ecosystems. J Ind Ecol 12:286\u2013296. https:\/\/doi.org\/10.1111\/j.1530-9290.2008.00041.x","journal-title":"J Ind Ecol"},{"key":"21027_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.143470","volume":"759","author":"A Malakar","year":"2021","unstructured":"Malakar A, Kanel SR, Ray C, Snow DD, Nadagouda MN (2021) Nanomaterials in the environment, human exposure pathway, and health effects: a review. Sci Total Environ 759:143470. https:\/\/doi.org\/10.1016\/j.scitotenv.2020.143470","journal-title":"Sci Total Environ"},{"key":"21027_CR45","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1007\/s00580-016-2333-y","volume":"25","author":"A Mansouri","year":"2016","unstructured":"Mansouri A, Fathi M, Mansouri B, Azadi N (2016a) Coexisting of titanium dioxide nanoparticles and diazinon on histopathology of common carp (Cyprinus carpio). Comp Clin Path 25:1227\u20131236. https:\/\/doi.org\/10.1007\/s00580-016-2333-y","journal-title":"Comp Clin Path"},{"issue":"10","key":"21027_CR46","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1007\/s10661-016-5579-6","volume":"188","author":"B Mansouri","year":"2016","unstructured":"Mansouri B, Maleki A, Davari B, Johari SA, Shahmoradi B, Mohammadi E, Shahsavari S (2016b) Histopathological effects following short-term coexposure of Cyprinus carpio to nanoparticles of TiO2 and CuO. Environ Monit Assess 188(10):575. https:\/\/doi.org\/10.1007\/s10661-016-5579-6","journal-title":"Environ Monit Assess"},{"key":"21027_CR47","unstructured":"Martoja R, Martoja-Pierson M (1967) Initiation aux techniques de l\u2019histologie animale. Paris: Masson:345 pp."},{"key":"21027_CR48","doi-asserted-by":"publisher","unstructured":"McCarthy MP, Carroll DL, Ringwood AH (2013) Tissue specific responses of oysters, Crassostrea virginica, to silver nanoparticles. Aquat Toxicol 138-139:123-8. https:\/\/doi.org\/10.1016\/j.aquatox.2013.04.015","DOI":"10.1016\/j.aquatox.2013.04.015"},{"issue":"8","key":"21027_CR49","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1016\/j.envint.2006.06.014","volume":"32","author":"MN Moore","year":"2006","unstructured":"Moore MN (2006) Do nanoparticles present ecotoxicological risks for the health of the aquatic environment? Environ Int 32(8):967\u2013976. https:\/\/doi.org\/10.1016\/j.envint.2006.06.014","journal-title":"Environ Int"},{"key":"21027_CR50","doi-asserted-by":"publisher","unstructured":"Nardi A, Benedetti M, Fattorini D, Regoli F (2018) Oxidative and interactive challenge of cadmium and ocean acidification on the smooth scallop Flexopecten glaber. Aquat Toxicol 196. https:\/\/doi.org\/10.1016\/j.aquatox.2018.01.008","DOI":"10.1016\/j.aquatox.2018.01.008"},{"issue":"6","key":"21027_CR51","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1002\/jemt.21130","volume":"75","author":"LR Nogarol","year":"2012","unstructured":"Nogarol LR, Brossi-Garcia AL, Fontanetti CS (2012) Surface morphology of Diplodon expansus (K\u00fcster, 1856; Mollusca, Bivalvia, Hyriidae) gill filaments after exposure to environmentally relevant concentrations of atrazine herbicide. Microsc Res Tech 75(6):807\u2013813. https:\/\/doi.org\/10.1002\/jemt.21130","journal-title":"Microsc Res Tech"},{"key":"21027_CR52","doi-asserted-by":"publisher","unstructured":"Ou P, Wolff SP (1996) A discontinuous method for catalase determination at near physiological concentrations of H2O2 and its application to the study of H2O2 fluxes within cells. J Biochem Biophys Methods 31(1e2):59-67. https:\/\/doi.org\/10.1016\/0165-022x(95)00039-t","DOI":"10.1016\/0165-022x(95)00039-t"},{"issue":"11","key":"21027_CR53","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1039\/c7em00186j","volume":"19","author":"L Pan","year":"2017","unstructured":"Pan L, Zhang M, Jin Q, Ji R (2017) Multi-biomarker approach in the scallop Chlamys farreri to assess PAHs pollution in Qingdao coastal areas of China. Environ Sci Process Impacts 19(11):1387\u20131403. https:\/\/doi.org\/10.1039\/c7em00186j","journal-title":"Environ Sci Process Impacts"},{"key":"21027_CR54","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.chemosphere.2015.08.025","volume":"144","author":"M Parolini","year":"2016","unstructured":"Parolini M, Magni S, Castiglioni S, Binelli A (2016) Amphetamine exposure imbalanced antioxidant activity in the bivalve Dreissena polymorpha causing oxidative and genetic damage. Chemosphere 144:207\u2013213. https:\/\/doi.org\/10.1016\/j.chemosphere.2015.08.025","journal-title":"Chemosphere"},{"key":"21027_CR55","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2020.126792","volume":"254","author":"AC Pereira","year":"2020","unstructured":"Pereira AC, Gon\u00e7alves BB, Brito RDS, Vieira LG, Lima ECO, Rocha TL (2020) Comparative developmental toxicity of iron oxide nanoparticles and ferric chloride to zebrafish (Danio rerio) after static and semi-static exposure. Chemosphere 254:126792. https:\/\/doi.org\/10.1016\/j.chemosphere.2020.126792","journal-title":"Chemosphere"},{"key":"21027_CR56","unstructured":"R Core Team, 2020. R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna, Austria. https:\/\/www.R-project.org\/."},{"issue":"3","key":"21027_CR57","doi-asserted-by":"publisher","DOI":"10.3989\/gya.0335201","volume":"72","author":"I Rabeh","year":"2021","unstructured":"Rabeh I, Telahigue K, Hajji T, Fouzai C, El Cafsi M, Soudani N (2021) Changes in fatty acid profile of Holothuria forskali muscle following acute mercury exposure. Grasas Aceites 72(3):e425. https:\/\/doi.org\/10.3989\/gya.0335201","journal-title":"Grasas Aceites"},{"key":"21027_CR58","doi-asserted-by":"crossref","unstructured":"Robinson WE, Langton RW (1980) Digestion in a subtidal population of Mercenariu mercenaria (Bivalvia). Mar Biol 58:113-l 79.","DOI":"10.1007\/BF00391873"},{"key":"21027_CR59","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2021.105910","volume":"237","author":"CC Rodrigues","year":"2021","unstructured":"Rodrigues CC, Caixeta MB, Ara\u00fajo PS, Gon\u00e7alves BB, Ara\u00fajo OA, Silva LD, Rocha TL (2021) Gonadal histopathology and inflammatory response in the freshwater snail exposed to iron oxide nanoparticles and ferric chloride: insights into reproductive nanotoxicity. Aquat Toxicol 237:105910. https:\/\/doi.org\/10.1016\/j.aquatox.2021.105910","journal-title":"Aquat Toxicol"},{"key":"21027_CR60","doi-asserted-by":"crossref","unstructured":"Saidani W, Sellami B, Khazri A, Mezni A, Dellali M, Joubert O, Sheehan D, Beyrem H (2019) Metal accumulation, biochemical and behavioral responses on the Mediterranean clams Ruditapes decussatus exposed to two photocatalyst nanocomposites (TiO2 NPs and AuTiO2 NPs) . Aquatic Toxicology 208:71-79. 10.1016\/j.aquatox.2019.01.003","DOI":"10.1016\/j.aquatox.2019.01.003"},{"key":"21027_CR61","doi-asserted-by":"publisher","DOI":"10.1016\/j.crgsc.2020.100042","volume":"4","author":"A Samrot","year":"2020","unstructured":"Samrot A, Sahithya C, Selvarani JA, Purayil SK, Ponnaiah P (2020) A review on synthesis, characterization and potential biological applications of superparamagnetic iron oxide nanoparticles. Curr Res Green Sustain Chem 4:100042. https:\/\/doi.org\/10.1016\/j.crgsc.2020.100042","journal-title":"Curr Res Green Sustain Chem"},{"key":"21027_CR62","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1007\/s11051-015-3082-6","volume":"17","author":"M Saravanan","year":"2015","unstructured":"Saravanan M, Suganya R, Ramesh M, Poopal R, Gopalan N, Nagamony P (2015) Iron oxide nanoparticles induced alterations in haematological, biochemical and ionoregulatory responses of an Indian major carp Labeo rohita. J Nanoparticle Res 17:274. https:\/\/doi.org\/10.1007\/s11051-015-3082-6","journal-title":"J Nanoparticle Res"},{"issue":"1","key":"21027_CR63","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1166\/jnn.2014.8752","volume":"14","author":"A Sarkar","year":"2014","unstructured":"Sarkar A, Ghosh M, Sil PC (2014) Nanotoxicity: oxidative stress mediated toxicity of metal and metal oxide nanoparticles. J Nanosci Nanotechnol 14(1):730\u2013743. https:\/\/doi.org\/10.1166\/jnn.2014.8752","journal-title":"J Nanosci Nanotechnol"},{"key":"21027_CR64","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.envpol.2016.05.051","volume":"216","author":"A Schiwy","year":"2016","unstructured":"Schiwy A, Maes HM, Koske D, Flecken M, Schmidt KR, Schell H, Tiehm A, Kamptner A, Thummler S, Stanjek H, Heggen M, Dunin-Borkowski RE, Braun J, Schaffer A, Hollert H (2016) The ecotoxic potential of a new zerovalent iron nanomaterial, designed for the elimination of halogenated pollutants, and its effect on reductive dechlorinating microbial communities. Environ Pollut 216:419\u2013427. https:\/\/doi.org\/10.1016\/j.envpol.2016.05.051","journal-title":"Environ Pollut"},{"key":"21027_CR65","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.aquatox.2017.04.005","volume":"188","author":"B Sellami","year":"2017","unstructured":"Sellami B, Mezni A, Khazri A, Bouzidi I, Saidani W, Sheehan D, Beyrem H (2017) Toxicity assessment of ZnO-decorated Au nanoparticles in the Mediterranean clam Ruditapes decussatus. Aquat Toxicol 188:10\u201319. https:\/\/doi.org\/10.1016\/j.aquatox.2017.04.005","journal-title":"Aquat Toxicol"},{"key":"21027_CR66","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2020.110611","volume":"194","author":"J Seyedi","year":"2021","unstructured":"Seyedi J, Tayemeh MB, Esmaeilbeigi M, Joo HS, Langeroudi EK, Banan A, Johari SA, Jami MJ (2021) Fatty acid alteration in liver, brain, muscle, and oocyte of zebrafish (Danio rerio) exposed to silver nanoparticles and mitigating influence of quercetin-supplemented diet. Environ Res 194:110611. https:\/\/doi.org\/10.1016\/j.envres.2020.110611","journal-title":"Environ Res"},{"key":"21027_CR67","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.ecoenv.2017.01.014","volume":"139","author":"X Sun","year":"2017","unstructured":"Sun X, Chen B, Xia B, Han Q, Zhu L, Qu K (2017) Are CuO nanoparticles effects on hemocytes of the marine scallop (Chlamys farreri) caused by particles and\/or corresponding released ions? Ecotoxicol Environ Saf 139:65\u201372. https:\/\/doi.org\/10.1016\/j.ecoenv.2017.01.014","journal-title":"Ecotoxicol Environ Saf"},{"key":"21027_CR68","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2019.124576","volume":"238","author":"BM Tayemeh","year":"2020","unstructured":"Tayemeh BM, Esmailbeigi M, Shirdel I, Joo HS, Johari SA, Banan A, Nourani H, Mashhadi H, Jami MJ, Tabarrok M (2020) Perturbation of fatty acid composition, pigments, and growth indices of Chlorella vulgaris in response to silver ions and nanoparticles: a new holistic understanding of hidden ecotoxicological aspect of pollutants. Chemosphere 238:124576. https:\/\/doi.org\/10.1016\/j.chemosphere.2019.124576","journal-title":"Chemosphere"},{"key":"21027_CR69","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.aquatox.2015.12.013","volume":"172","author":"C Taze","year":"2016","unstructured":"Taze C, Panetas I, Kalogiannis S, Feidantsis K, Gallios GP, Kastrinaki G, Konstandopoulos AG, V\u00e1clav\u00edkov\u00e1 M, Ivanicova L, Kaloyianni M (2016) Toxicity assessment and comparison between two types of iron oxide nanoparticles in Mytilus galloprovincialis. Aquat Toxicol 172:9\u201320. https:\/\/doi.org\/10.1016\/j.aquatox.2015.12.013","journal-title":"Aquat Toxicol"},{"key":"21027_CR70","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.cbpc.2009.10.002","volume":"151","author":"S Tedesco","year":"2010","unstructured":"Tedesco S, Doyle H, Blasco J, Redmond G, Sheehan D (2010) Exposure of the blue mussel, Mytilus edulis, to gold nanoparticles and the pro-oxidant menadione. Comp Biochem Physiol Part C: Toxicol Pharmacol 151:167\u2013174. https:\/\/doi.org\/10.1016\/j.cbpc.2009.10.002","journal-title":"Comp Biochem Physiol Part C: Toxicol Pharmacol"},{"key":"21027_CR71","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1016\/j.foodchem.2010.03.047","volume":"122","author":"K Telahigue","year":"2010","unstructured":"Telahigue K, Chetoui I, Rabeh I, Romdhane MS, El Cafsi M (2010) Comparative fatty acid profiles in edible parts of wild scallops from the Tunisian coast. Food Chem 122:744\u2013746. https:\/\/doi.org\/10.1016\/j.foodchem.2010.03.047","journal-title":"Food Chem"},{"key":"21027_CR72","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.ecoenv.2018.11.051","volume":"169","author":"K Telahigue","year":"2019","unstructured":"Telahigue K, Rabeh I, Hajji T, Trabelsi W, Bejaoui S, Chouba L, El Cafsi M, Soudani N (2019) Effects of acute mercury exposure on fatty acid composition and oxidative stress biomarkers in Holothuria forskali body wall. Ecotoxicol Environ Saf 169:516\u2013522. https:\/\/doi.org\/10.1016\/j.ecoenv.2018.11.051","journal-title":"Ecotoxicol Environ Saf"},{"key":"21027_CR73","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2020.129376","volume":"269","author":"K Telahigue","year":"2021","unstructured":"Telahigue K, Rabeh I, Hajji T, Trabelsi W, Fouzai C, Nechi S, Chelbi E, El Cafsi M, Soudani N (2021) Assessment of the impacts of glyphosate and its commercial formulation Roundup\u00ae on the respiratory tree of the sea cucumber Holothuria forskali using a multivariate biomarker approach. Chemosphere 269:129376. https:\/\/doi.org\/10.1016\/j.chemosphere.2020.129376","journal-title":"Chemosphere"},{"key":"21027_CR74","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1134\/S1063074006020040","volume":"32","author":"LN Usheva","year":"2006","unstructured":"Usheva LN, Frolova LT (2006) Morphofunctional changes of the digestive gland in the bivalve mollusk Crenomytilus grayanus (Dunker, 1853) in normal conditions and after parasitic invasion by trematodes. Russ J Mar Biol 32:96","journal-title":"Russ J Mar Biol"},{"key":"21027_CR75","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1039\/C6EN00365F","volume":"4","author":"Z Wang","year":"2017","unstructured":"Wang Z, Xia B, Chen B, Sun X, Zhu L, Zhao J, Du P, Xing B (2017) Trophic transfer of TiO2 nanoparticles from marine microalga (Nitzschia closterium) to scallop (Chlamys farreri) and related toxicity. Environ Sci Nano 4:415\u2013424. https:\/\/doi.org\/10.1039\/C6EN00365F","journal-title":"Environ Sci Nano"},{"key":"21027_CR76","first-page":"137","volume":"68","author":"JE Ward","year":"2009","unstructured":"Ward JE, Kach DJ (2009) Marine aggregates facilitate ingestion of nanoparticles by suspension-feeding bivalves Mar. Environ. Res. 68:137\u2013142","journal-title":"Environ. Res."},{"key":"21027_CR77","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.etap.2017.01.016","volume":"50","author":"B Xia","year":"2017","unstructured":"Xia B, Zhu L, Han Q, Sun X, Chen B, Qu K (2017) Effects of TiO2 nanoparticles at predicted environmental relevant concentration on the marine scallop Chlamys farreri: an integrated biomarker approach. Environ Toxicol Pharmacol 50:128\u2013135. https:\/\/doi.org\/10.1016\/j.etap.2017.01.016","journal-title":"Environ Toxicol Pharmacol"},{"key":"21027_CR78","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2019.113504","volume":"256","author":"QQ Xiang","year":"2019","unstructured":"Xiang QQ, Wang D, Zhang JL, Ding C, Luo X, Tao J, Ling J, Shea D, Chen LQ (2019) Effect of silver nanoparticles on gill membranes of common carp: modification of fatty acid profile, lipid peroxidation and membrane fluidity. Environ Pollut 256:113504. https:\/\/doi.org\/10.1016\/j.envpol.2019.113504","journal-title":"Environ Pollut"},{"issue":"Pt B","key":"21027_CR79","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1016\/j.envpol.2019.05.154","volume":"252","author":"CH Yang","year":"2019","unstructured":"Yang CH, Kung TA, Chen PJ (2019) Differential alteration in reproductive toxicity of medaka fish on exposure to nanoscale zerovalent iron and its oxidation products. Environ Pollut 252(Pt B):1920\u20131932. https:\/\/doi.org\/10.1016\/j.envpol.2019.05.154","journal-title":"Environ Pollut"},{"key":"21027_CR80","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.ecoenv.2018.07.099","volume":"163","author":"H Yoon","year":"2018","unstructured":"Yoon H, Pangging M, Jang M, Hwang Y, Chang Y (2018) Impact of surface modification on the toxicity of zerovalent iron nanoparticles in aquatic and terrestrial organisms. Ecotoxicol Environ Saf 163:436\u2013443. https:\/\/doi.org\/10.1016\/j.ecoenv.2018.07.099","journal-title":"Ecotoxicol Environ Saf"},{"key":"21027_CR81","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1016\/j.toxrep.2020.11.009","volume":"7","author":"E Zapata Vivenes","year":"2020","unstructured":"Zapata Vivenes E, Nusetti O, Marcano L, S\u00e1nchez G, Guderley H (2020) Antioxidant defenses of flame scallop Ctenoides scaber (Born, 1778) exposed to the water-soluble fraction of used vehicle crankcase oils. Toxicol Rep 7:1597\u20131606. https:\/\/doi.org\/10.1016\/j.toxrep.2020.11.009","journal-title":"Toxicol Rep"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-022-21027-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11356-022-21027-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-022-21027-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T21:06:45Z","timestamp":1666386405000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11356-022-21027-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,11]]},"references-count":81,"journal-issue":{"issue":"52","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["21027"],"URL":"https:\/\/doi.org\/10.1007\/s11356-022-21027-x","relation":{},"ISSN":["0944-1344","1614-7499"],"issn-type":[{"value":"0944-1344","type":"print"},{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,11]]},"assertion":[{"value":"13 September 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}