{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T12:23:26Z","timestamp":1769343806314,"version":"3.49.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"51","license":[{"start":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T00:00:00Z","timestamp":1654560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T00:00:00Z","timestamp":1654560000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91943301"],"award-info":[{"award-number":["91943301"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92043301"],"award-info":[{"award-number":["92043301"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1007\/s11356-022-21088-y","type":"journal-article","created":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T16:09:48Z","timestamp":1654618188000},"page":"76816-76832","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Microarray analysis of mRNA expression profiles in liver of ob\/ob mice with real-time atmospheric PM2.5 exposure"],"prefix":"10.1007","volume":"29","author":[{"given":"Lisen","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengqi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junchao","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiwei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,6,7]]},"reference":[{"key":"21088_CR1","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1186\/1472-6882-14-426","volume":"14","author":"IJ Atangwho","year":"2014","unstructured":"Atangwho IJ, Yin KB, Umar MI et al (2014) Vernonia amygdalina simultaneously suppresses gluconeogenesis and potentiates glucose oxidation via the pentose phosphate pathway in streptozotocin-induced diabetic rats. BMC Complement Altern Med [j] 14:426","journal-title":"BMC Complement Altern Med [j]"},{"key":"21088_CR2","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1089\/thy.2019.0572","volume":"30","author":"A Bano","year":"2020","unstructured":"Bano A, Chaker L, Muka T et al (2020) Thyroid function and the risk of fibrosis of the liver, heart, and lung in humans: a systematic review and meta-analysis. Thyroid [j] 30:806\u2013820","journal-title":"Thyroid [j]"},{"key":"21088_CR3","doi-asserted-by":"publisher","first-page":"e760","DOI":"10.1016\/S2542-5196(21)00287-4","volume":"5","author":"H Carvalho","year":"2021","unstructured":"Carvalho H (2021) New WHO global air quality guidelines: more pressure on nations to reduce air pollution levels. Lancet Planet Health [j] 5:e760\u2013e761","journal-title":"Lancet Planet Health [j]"},{"key":"21088_CR4","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s10072-014-1889-z","volume":"36","author":"S Cui","year":"2015","unstructured":"Cui S, Sun H, Gu X et al (2015) Gene expression profiling analysis of locus coeruleus in idiopathic Parkinson\u2019s disease by bioinformatics. Neurol Sci [j] 36:97\u2013102","journal-title":"Neurol Sci [j]"},{"key":"21088_CR5","doi-asserted-by":"publisher","first-page":"13998","DOI":"10.1073\/pnas.0810087106","volume":"106","author":"JA Ehses","year":"2009","unstructured":"Ehses JA, Lacraz G, Giroix MH et al (2009) IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat. Proc Natl Acad Sci U S A [j] 106:13998\u201314003","journal-title":"Proc Natl Acad Sci U S A [j]"},{"key":"21088_CR6","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1002\/hep.23280","volume":"51","author":"E Fabbrini","year":"2010","unstructured":"Fabbrini E, Sullivan S, Klein S (2010) Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology [j] 51:679\u2013689","journal-title":"Hepatology [j]"},{"key":"21088_CR7","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s13046-018-0673-y","volume":"37","author":"Q Fan","year":"2018","unstructured":"Fan Q, Yang L, Zhang X et al (2018) Autophagy promotes metastasis and glycolysis by upregulating MCT1 expression and Wnt\/\u03b2-catenin signaling pathway activation in hepatocellular carcinoma cells. J Exp Clin Cancer Res [j] 37:9","journal-title":"J Exp Clin Cancer Res [j]"},{"key":"21088_CR8","doi-asserted-by":"publisher","first-page":"e1912902","DOI":"10.1001\/jamanetworkopen.2019.12902","volume":"2","author":"A Ghassabian","year":"2019","unstructured":"Ghassabian A, Pierotti L, Basterrechea M et al (2019) Association of exposure to ambient air pollution with thyroid function during pregnancy. JAMA Netw Open [j] 2:e1912902","journal-title":"JAMA Netw Open [j]"},{"key":"21088_CR9","doi-asserted-by":"publisher","first-page":"H1423","DOI":"10.1152\/ajpheart.00369.2015","volume":"310","author":"P Haberzettl","year":"2016","unstructured":"Haberzettl P, Mccracken JP, Bhatnagar A et al (2016) Insulin sensitizers prevent fine particulate matter-induced vascular insulin resistance and changes in endothelial progenitor cell homeostasis. Am J Physiol Heart Circ Physiol [j] 310:H1423-1438","journal-title":"Am J Physiol Heart Circ Physiol [j]"},{"key":"21088_CR10","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/S0014-5793(00)01889-5","volume":"479","author":"E Hajduch","year":"2000","unstructured":"Hajduch E, Heyes RR, Watt PW et al (2000) Lactate transport in rat adipocytes: identification of monocarboxylate transporter 1 (MCT1) and its modulation during streptozotocin-induced diabetes. FEBS Lett [j] 479:89\u201392","journal-title":"FEBS Lett [j]"},{"key":"21088_CR11","doi-asserted-by":"publisher","first-page":"e218","DOI":"10.1038\/emm.2015.122","volume":"48","author":"HS Han","year":"2016","unstructured":"Han HS, Kang G, Kim JS et al (2016) Regulation of glucose metabolism from a liver-centric perspective. Exp Mol Med [j] 48:e218","journal-title":"Exp Mol Med [j]"},{"key":"21088_CR12","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.cell.2009.03.016","volume":"137","author":"L He","year":"2009","unstructured":"He L, Sabet A, Djedjos S et al (2009) Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein. Cell [j] 137:635\u2013646","journal-title":"Cell [j]"},{"key":"21088_CR13","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1111\/ijpo.12228","volume":"13","author":"S Hsieh","year":"2018","unstructured":"Hsieh S, Leaderer BP, Feldstein AE et al (2018) Traffic-related air pollution associations with cytokeratin-18, a marker of hepatocellular apoptosis, in an overweight and obese paediatric population. Pediatr Obes [j] 13:342\u2013347","journal-title":"Pediatr Obes [j]"},{"key":"21088_CR14","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/s41575-020-00381-6","volume":"18","author":"DQ Huang","year":"2021","unstructured":"Huang DQ, El-Serag HB, Loomba R (2021) Global epidemiology of NAFLD-related HCC: trends, predictions, risk factors and prevention. Nat Rev Gastroenterol Hepatol [j] 18:223\u2013238","journal-title":"Nat Rev Gastroenterol Hepatol [j]"},{"key":"21088_CR15","doi-asserted-by":"publisher","first-page":"e0141642","DOI":"10.1371\/journal.pone.0141642","volume":"10","author":"F Huang","year":"2015","unstructured":"Huang F, Li X, Wang C et al (2015) PM2.5 Spatiotemporal variations and the relationship with meteorological factors during 2013\u20132014 in Beijing, China. Plos One [J] 10:e0141642","journal-title":"Plos One [J]"},{"issue":"1","key":"21088_CR16","doi-asserted-by":"publisher","first-page":"160","DOI":"10.3390\/ijerph15010160","volume":"15","author":"Z Jia","year":"2018","unstructured":"Jia Z, Wei Y, Li X et al (2018) Exposure to ambient air particles increases the risk of mental disorder: findings from a natural experiment in Beijing. Int J Environ Res Public Health 15(1):160. https:\/\/doi.org\/10.3390\/ijerph15010160","journal-title":"Int J Environ Res Public Health"},{"key":"21088_CR17","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.bbalip.2014.05.001","volume":"1851","author":"P Karagianni","year":"2015","unstructured":"Karagianni P, Talianidis I (2015) Transcription factor networks regulating hepatic fatty acid metabolism. Biochim Biophys Acta [j] 1851:2\u20138","journal-title":"Biochim Biophys Acta [j]"},{"issue":"8","key":"21088_CR18","doi-asserted-by":"publisher","first-page":"dgaa338","DOI":"10.1210\/clinem\/dgaa338","volume":"105","author":"HJ Kim","year":"2020","unstructured":"Kim HJ, Kwon H, Yun JM et al (2020) Association between exposure to ambient air pollution and thyroid function in Korean adults. J Clin Endocrinol Metab 105(8):dgaa338. https:\/\/doi.org\/10.1210\/clinem\/dgaa338","journal-title":"J Clin Endocrinol Metab"},{"key":"21088_CR19","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1186\/1471-2105-9-559","volume":"9","author":"P Langfelder","year":"2008","unstructured":"Langfelder P, Horvath S (2008) WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics [j] 9:559","journal-title":"BMC Bioinformatics [j]"},{"key":"21088_CR20","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.scitotenv.2019.01.346","volume":"663","author":"S Liang","year":"2019","unstructured":"Liang S, Zhao T, Hu H et al (2019) Repeat dose exposure of PM2.5 triggers the disseminated intravascular coagulation (DIC) in SD rats. Sci Total Environ [j] 663:245\u2013253","journal-title":"Sci Total Environ [j]"},{"key":"21088_CR21","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/j.envpol.2019.03.045","volume":"249","author":"J Liu","year":"2019","unstructured":"Liu J, Liang S, Du Z et al (2019) PM(2.5) aggravates the lipid accumulation, mitochondrial damage and apoptosis in macrophage foam cells. Environ Pollut [j] 249:482\u2013490","journal-title":"Environ Pollut [j]"},{"key":"21088_CR22","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1289\/EHP135","volume":"124","author":"R Liu","year":"2016","unstructured":"Liu R, Young MT, Chen JC et al (2016) Ambient air pollution exposures and risk of Parkinson disease. Environ Health Perspect [j] 124:1759\u20131765","journal-title":"Environ Health Perspect [j]"},{"key":"21088_CR23","doi-asserted-by":"publisher","first-page":"2295","DOI":"10.2337\/db15-1122","volume":"65","author":"T Luo","year":"2016","unstructured":"Luo T, Nocon A, Fry J et al (2016) AMPK activation by metformin suppresses abnormal extracellular matrix remodeling in adipose tissue and ameliorates insulin resistance in obesity. Diabetes [j] 65:2295\u20132310","journal-title":"Diabetes [j]"},{"key":"21088_CR24","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1038\/s41591-018-0125-4","volume":"24","author":"AK Madiraju","year":"2018","unstructured":"Madiraju AK, Qiu Y, Perry RJ et al (2018) Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo. Nat Med [j] 24:1384\u20131394","journal-title":"Nat Med [j]"},{"key":"21088_CR25","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.cmet.2017.06.014","volume":"26","author":"N Mart\u00ednez-S\u00e1nchez","year":"2017","unstructured":"Mart\u00ednez-S\u00e1nchez N, Seoane-Collazo P, Contreras C et al (2017) Hypothalamic AMPK-ER stress-JNK1 axis mediates the central actions of thyroid hormones on energy balance. Cell Metab [j] 26:212-229.e212","journal-title":"Cell Metab [j]"},{"key":"21088_CR26","first-page":"5","volume":"244","author":"A Mukherjee","year":"2018","unstructured":"Mukherjee A, Agrawal M (2018) A global perspective of fine particulate matter pollution and its health effects. Rev Environ Contam Toxicol [j] 244:5\u201351","journal-title":"Rev Environ Contam Toxicol [j]"},{"key":"21088_CR27","doi-asserted-by":"publisher","first-page":"17423","DOI":"10.1038\/s41598-019-53716-y","volume":"9","author":"H Reyes-Caballero","year":"2019","unstructured":"Reyes-Caballero H, Rao X, Sun Q et al (2019) Air pollution-derived particulate matter dysregulates hepatic Krebs cycle, glucose and lipid metabolism in mice. Sci Rep [j] 9:17423","journal-title":"Sci Rep [j]"},{"key":"21088_CR28","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1002\/hep.31296","volume":"72","author":"MJ Ritter","year":"2020","unstructured":"Ritter MJ, Amano I, Hollenberg AN (2020) Thyroid hormone signaling and the liver. Hepatology [j] 72:742\u2013752","journal-title":"Hepatology [j]"},{"key":"21088_CR29","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1089\/thy.2010.0322","volume":"21","author":"P Romanque","year":"2011","unstructured":"Romanque P, Cornejo P, Vald\u00e9s S et al (2011) Thyroid hormone administration induces rat liver Nrf2 activation: suppression by N-acetylcysteine pretreatment. Thyroid [j] 21:655\u2013662","journal-title":"Thyroid [j]"},{"issue":"9","key":"21088_CR30","doi-asserted-by":"publisher","first-page":"1766","DOI":"10.3390\/molecules24091766","volume":"24","author":"Q Shi","year":"2019","unstructured":"Shi Q, Zhao L, Xu C et al (2019) High molecular weight hyaluronan suppresses macrophage M1 polarization and enhances IL-10 production in PM(2.5)-induced lung inflammation. Molecules 24(9):1766. https:\/\/doi.org\/10.3390\/molecules24091766","journal-title":"Molecules"},{"key":"21088_CR31","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1136\/gutjnl-2020-322786","volume":"70","author":"TG Simon","year":"2021","unstructured":"Simon TG, Roelstraete B, Khalili H et al (2021) Mortality in biopsy-confirmed nonalcoholic fatty liver disease: results from a nationwide cohort. Gut [j] 70:1375\u20131382","journal-title":"Gut [j]"},{"key":"21088_CR32","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1038\/nrendo.2018.10","volume":"14","author":"RA Sinha","year":"2018","unstructured":"Sinha RA, Singh BK, Yen PM (2018) Direct effects of thyroid hormones on hepatic lipid metabolism. Nat Rev Endocrinol [j] 14:259\u2013269","journal-title":"Nat Rev Endocrinol [j]"},{"issue":"2","key":"21088_CR33","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1136\/gutjnl-2021-324364","volume":"71","author":"S Sun","year":"2021","unstructured":"Sun S, Yang Q, Zhou Q et al (2021) Long-term exposure to fine particulate matter and non-alcoholic fatty liver disease: a prospective cohort study. Gut 71(2):443\u2013445. https:\/\/doi.org\/10.1136\/gutjnl-2021-324364","journal-title":"Gut"},{"key":"21088_CR34","doi-asserted-by":"publisher","first-page":"6805","DOI":"10.2147\/OTT.S258439","volume":"13","author":"Z Tian","year":"2020","unstructured":"Tian Z, He W, Tang J et al (2020) Identification of important modules and biomarkers in breast cancer based on WGCNA. Onco Targets Ther [j] 13:6805\u20136817","journal-title":"Onco Targets Ther [j]"},{"key":"21088_CR35","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1007\/s00228-008-0553-z","volume":"64","author":"RK Verbeeck","year":"2008","unstructured":"Verbeeck RK (2008) Pharmacokinetics and dosage adjustment in patients with hepatic dysfunction. Eur J Clin Pharmacol [j] 64:1147\u20131161","journal-title":"Eur J Clin Pharmacol [j]"},{"key":"21088_CR36","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1007\/s10552-018-1036-x","volume":"29","author":"T Vopham","year":"2018","unstructured":"Vopham T, Bertrand KA, Tamimi RM et al (2018) Ambient PM(2.5) air pollution exposure and hepatocellular carcinoma incidence in the United States. Cancer Causes Control [j] 29:563\u2013572","journal-title":"Cancer Causes Control [j]"},{"key":"21088_CR37","doi-asserted-by":"crossref","unstructured":"Wang Y, Li C, Zhang X, et al. (2021) Exposure to PM2.5 aggravates Parkinson\u2019s disease via inhibition of autophagy and mitophagy pathway. Toxicology [J] 456:152770","DOI":"10.1016\/j.tox.2021.152770"},{"key":"21088_CR38","doi-asserted-by":"crossref","unstructured":"Weichenthal S, Hoppin J A, Reeves F (2014) Obesity and the cardiovascular health effects of fine particulate air pollution. Obesity (Silver Spring) [J] 22:1580\u20131589","DOI":"10.1002\/oby.20748"},{"key":"21088_CR39","unstructured":"WHO (2021a)\u00a0WHO global air quality guidelines: particulate matter (PM2.5 and PM10), ozone, nitrogen dioxide, sulfur dioxide and carbon\u00a0monoxide. https:\/\/www.who.int\/publications\/i\/item\/9789240034228"},{"key":"21088_CR40","unstructured":"WHO (2021b) Ambient (outdoor) air pollution. World Health Organization. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/ambient-(outdoor)-air-quality-and-health"},{"key":"21088_CR41","doi-asserted-by":"publisher","first-page":"25071","DOI":"10.1007\/s11356-017-0090-3","volume":"24","author":"J Wu","year":"2017","unstructured":"Wu J, Shi Y, Asweto CO et al (2017) Fine particle matters induce DNA damage and G2\/M cell cycle arrest in human bronchial epithelial BEAS-2B cells. Environ Sci Pollut Res Int [j] 24:25071\u201325081","journal-title":"Environ Sci Pollut Res Int [j]"},{"key":"21088_CR42","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/j.freeradbiomed.2018.11.016","volume":"130","author":"MX Xu","year":"2019","unstructured":"Xu MX, Ge CX, Qin YT et al (2019) Prolonged PM2.5 exposure elevates risk of oxidative stress-driven nonalcoholic fatty liver disease by triggering increase of dyslipidemia. Free Radic Biol Med [j] 130:542\u2013556","journal-title":"Free Radic Biol Med [j]"},{"key":"21088_CR43","doi-asserted-by":"crossref","unstructured":"Yan R, Ku T, Yue H, et al. (2020) PM(2.5) exposure induces age-dependent hepatic lipid metabolism disorder in female mice. J Environ Sci (China) [J] 89:227\u2013237","DOI":"10.1016\/j.jes.2019.10.014"},{"key":"21088_CR44","first-page":"4516349","volume":"2020","author":"H Yu","year":"2020","unstructured":"Yu H, Liu Y, Li C et al (2020) Bioinformatic analysis of neuroimmune mechanism of neuropathic pain. Biomed Res Int [j] 2020:4516349","journal-title":"Biomed Res Int [j]"},{"key":"21088_CR45","doi-asserted-by":"publisher","first-page":"7657","DOI":"10.1038\/s41598-019-44009-5","volume":"9","author":"AV Zaitsev","year":"2019","unstructured":"Zaitsev AV, Martinov MV, Vitvitsky VM et al (2019) Rat liver folate metabolism can provide an independent functioning of associated metabolic pathways. Sci Rep [j] 9:7657","journal-title":"Sci Rep [j]"},{"key":"21088_CR46","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.jhep.2012.08.009","volume":"58","author":"Z Zheng","year":"2013","unstructured":"Zheng Z, Xu X, Zhang X et al (2013) Exposure to ambient particulate matter induces a NASH-like phenotype and impairs hepatic glucose metabolism in an animal model. J Hepatol [j] 58:148\u2013154","journal-title":"J Hepatol [j]"},{"key":"21088_CR47","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1016\/j.jhep.2015.07.020","volume":"63","author":"Z Zheng","year":"2015","unstructured":"Zheng Z, Zhang X, Wang J et al (2015) Exposure to fine airborne particulate matters induces hepatic fibrosis in murine models. J Hepatol [j] 63:1397\u20131404","journal-title":"J Hepatol [j]"},{"key":"21088_CR48","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","volume":"10","author":"Y Zhou","year":"2019","unstructured":"Zhou Y, Zhou B, Pache L et al (2019) Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat Commun [j] 10:1523","journal-title":"Nat Commun [j]"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-022-21088-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11356-022-21088-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-022-21088-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T07:24:10Z","timestamp":1666164250000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11356-022-21088-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,7]]},"references-count":48,"journal-issue":{"issue":"51","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["21088"],"URL":"https:\/\/doi.org\/10.1007\/s11356-022-21088-y","relation":{},"ISSN":["0944-1344","1614-7499"],"issn-type":[{"value":"0944-1344","type":"print"},{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,7]]},"assertion":[{"value":"11 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 May 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This work has received approval for research ethics from the Animal Care and Use Committee of Capital Medical University, which ethical approval number is AEEI-2019\u2013161.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All listed authors have approved the manuscript before submission, including the names and order of authors.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}