{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:43:29Z","timestamp":1790811809901,"version":"4.1.0"},"reference-count":120,"publisher":"Springer Science and Business Media LLC","issue":"51","license":[{"start":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T00:00:00Z","timestamp":1654819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T00:00:00Z","timestamp":1654819200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002386","name":"Cairo University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002386","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The aim of this study is to investigate the protective effect of polyethylene glycol capped gold nanoparticles (PEG-AuNPs) on renal ischemia\u2013reperfusion injury (I\/R)\u2013induced acute kidney injury (AKI) in diabetic mice via the activation of adenosine 5\u2032 monophosphate\u2013activated protein kinase\u2014nuclear factor erythroid-2-related factor-2 (AMPK-Nrf2) pathway. Diabetes was induced in male mice (12\/group) by streptozotocin (50\u00a0mg\/kg) for 5 consecutive days. After 4\u00a0weeks, the mice have intravenously received doses of PEG-AuNPs (40, 150, and 400\u00a0\u00b5g\/kg body weight) for 3 consecutive days, and then animals were subjected to 30\u00a0min ischemia and 48\u00a0h reperfusion. Following the treatment with three different doses of PEG-AuNPs, the levels of blood urea nitrogen (BUN) and creatinine were reduced. Obvious reduction in renal tubular atrophy, glomerular damage, mitochondrial damage, and necrotic area were ultra-structurally detected, and renal interstitial inflammation and apoptosis were diminished. Moreover, PEG-AuNPs increased the recovering of damaged renal cells, suppressed significantly levels of malondialdehyde (MDA), downregulated significantly the level of inflammatory cytokines (TNF-\u03b1 and IL-1\u03b2), and upregulated the AMPK-Nrf2 pathway. PEG-AuNPs exhibited a promising alternative therapeutic target for diabetic renal I\/R-induced AKI through upregulation of AMPK\/PI3K\/AKT path which additionally stimulated Nrf2-regulated antioxidant enzymes in a dose-dependent manner.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Graphical abstract<\/jats:bold>\n                  <\/jats:p>","DOI":"10.1007\/s11356-022-21235-5","type":"journal-article","created":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T12:20:00Z","timestamp":1654863600000},"page":"77884-77907","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Polyethylene glycol capped gold nanoparticles ameliorate renal ischemia\u2013reperfusion injury in diabetic mice through AMPK-Nrf2 signaling pathway"],"prefix":"10.1007","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3979-5301","authenticated-orcid":false,"given":"Hanan","family":"Saleh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Salama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehab Mohamed","family":"Hussein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,10]]},"reference":[{"key":"21235_CR1","doi-asserted-by":"crossref","unstructured":"Ahmed SMU, Luo L, Namani A et al (2017) Nrf2 signaling pathway: pivotal roles in inflammation. Biochimica et Biophysica Acta (BBA) - Molecular basis of disease 1863(2): 585\u2013597","DOI":"10.1016\/j.bbadis.2016.11.005"},{"key":"21235_CR2","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1080\/21691401.2018.1430585","volume":"46","author":"S Bagheri","year":"2018","unstructured":"Bagheri S, Yasemi M, Safaie-Qamsari E et al (2018) Using gold nanoparticles in diagnosis and treatment of melanoma cancer. Artificial Cells Nanomedicine Biotechnol 46:462\u2013471","journal-title":"Artificial Cells Nanomedicine Biotechnol"},{"issue":"9","key":"21235_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0076790","volume":"8","author":"K Ban","year":"2013","unstructured":"Ban K, Peng Z, Kozar RA (2013) Inhibition of ERK1\/2 worsens intestinal ischemia\/reperfusion injury. PLoS ONE 8(9):1\u201311","journal-title":"PLoS ONE"},{"issue":"1","key":"21235_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1477-3155-8-16","volume":"8","author":"S BarathManiKanth","year":"2010","unstructured":"BarathManiKanth S, Kalishwaralal K, Sriram M et al (2010) Anti-oxidant effect of gold nanoparticles restrains hyperglycemic conditions in diabetic mice. J Nanobiotechnology 8(1):1\u201316","journal-title":"J Nanobiotechnology"},{"issue":"3","key":"21235_CR5","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1681\/ASN.2015030309","volume":"27","author":"DP Basile","year":"2016","unstructured":"Basile DP, Bonventre JV, Mehta R et al (2016) Progression after AKI: understanding maladaptive repair processes to predict and identify therapeutic treatments. J Am Soc Nephrol 27(3):687\u2013697","journal-title":"J Am Soc Nephrol"},{"key":"21235_CR6","first-page":"882","volume":"61","author":"EJJLCM Beutler","year":"1963","unstructured":"Beutler EJJLCM (1963) Improved method for the determination of blood glutathione. J Lab Clin Med 61:882\u2013888","journal-title":"J Lab Clin Med"},{"issue":"6","key":"21235_CR7","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1039\/b806051g","volume":"38","author":"E Boisselier","year":"2009","unstructured":"Boisselier E, Astruc D (2009) Gold nanoparticles in nanomedicine: preparations, imaging, diagnostics, therapies and toxicity. Chem Soc Rev 38(6):1759\u20131782","journal-title":"Chem Soc Rev"},{"issue":"5","key":"21235_CR8","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1038\/ki.1993.163","volume":"43","author":"JV Bonventre","year":"1993","unstructured":"Bonventre JV (1993) Mechanisms of ischemic acute renal failure. Kidney Int 43(5):1160\u20131178","journal-title":"Kidney Int"},{"issue":"11","key":"21235_CR9","doi-asserted-by":"publisher","first-page":"4210","DOI":"10.1172\/JCI45161","volume":"121","author":"JV Bonventre","year":"2011","unstructured":"Bonventre JV, Yang L (2011) Cellular pathophysiology of ischemic acute kidney injury. J Clin Investig 121(11):4210\u20134221","journal-title":"J Clin Investig"},{"issue":"5","key":"21235_CR10","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1172\/JCI37829","volume":"119","author":"C Brooks","year":"2009","unstructured":"Brooks C, Wei Q, Cho S-G et al (2009) Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models. J Clin Investig 119(5):1275\u20131285","journal-title":"J Clin Investig"},{"issue":"3","key":"21235_CR11","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/S0959-4388(00)00211-7","volume":"11","author":"A Brunet","year":"2001","unstructured":"Brunet A, Datta SR, Greenberg ME (2001) Transcription-dependent and -independent control of neuronal survival by the PI3K\u2013Akt signaling pathway. Curr Opin Neurobiol 11(3):297\u2013305","journal-title":"Curr Opin Neurobiol"},{"issue":"2","key":"21235_CR12","doi-asserted-by":"publisher","first-page":"513","DOI":"10.3892\/etm.2015.2514","volume":"10","author":"H Chen","year":"2015","unstructured":"Chen H, Wang L, Xing BZ et al (2015) Ischemic postconditioning attenuates inflammation in rats following renal ischemia and reperfusion injury. Exp Ther Med 10(2):513\u2013518","journal-title":"Exp Ther Med"},{"key":"21235_CR13","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.impact.2017.07.005","volume":"8","author":"H Chen","year":"2017","unstructured":"Chen H, Zhao R, Wang B et al (2017) The effects of orally administered Ag, TiO2 and SiO2 nanoparticles on gut microbiota composition and colitis induction in mice. NanoImpact 8:80\u201388","journal-title":"NanoImpact"},{"issue":"6","key":"21235_CR14","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.1021\/nl070363y","volume":"7","author":"BD Chithrani","year":"2007","unstructured":"Chithrani BD, Chan WCW (2007) Elucidating the mechanism of cellular uptake and removal of protein-coated gold nanoparticles of different sizes and shapes. Nano Lett 7(6):1542\u20131550","journal-title":"Nano Lett"},{"issue":"1","key":"21235_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-230X-13-69","volume":"13","author":"SS Cho","year":"2013","unstructured":"Cho SS, Rudloff I, Berger PJ et al (2013) Remifentanil ameliorates intestinal ischemia-reperfusion injury. BMC Gastroenterol 13(1):1\u20139","journal-title":"BMC Gastroenterol"},{"issue":"3","key":"21235_CR16","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1002\/smll.200400093","volume":"1","author":"EE Connor","year":"2005","unstructured":"Connor EE, Mwamuka J, Gole A et al (2005) Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity. Small 1(3):325\u2013327","journal-title":"Small"},{"issue":"1","key":"21235_CR17","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1021\/cr030698+","volume":"104","author":"M-C Daniel","year":"2004","unstructured":"Daniel M-C, Astruc D (2004) Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. Chem Rev 104(1):293\u2013346","journal-title":"Chem Rev"},{"key":"21235_CR18","doi-asserted-by":"publisher","first-page":"1912","DOI":"10.1016\/j.biomaterials.2007.12.037","volume":"29","author":"WH De Jong","year":"2008","unstructured":"De Jong WH (2008) Particle size-dependent organ distribution of gold nanoparticles after intravenous administration. Biomaterials 29:1912\u20131919","journal-title":"Biomaterials"},{"issue":"12","key":"21235_CR19","doi-asserted-by":"publisher","first-page":"1912","DOI":"10.1016\/j.biomaterials.2007.12.037","volume":"29","author":"WH De Jong","year":"2008","unstructured":"De Jong WH, Hagens WI, Krystek P et al (2008) Particle size-dependent organ distribution of gold nanoparticles after intravenous administration. Biomaterials 29(12):1912\u20131919","journal-title":"Biomaterials"},{"issue":"3\u20134","key":"21235_CR20","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1159\/000368932","volume":"128","author":"A-E Decl\u00e8ves","year":"2014","unstructured":"Decl\u00e8ves A-E, Sharma K, Satriano J (2014a) Beneficial effects of AMP-activated protein kinase agonists in kidney ischemia-reperfusion: autophagy and cellular stress markers. Nephron Exp Nephrol 128(3\u20134):98\u2013110","journal-title":"Nephron Exp Nephrol"},{"issue":"3","key":"21235_CR21","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1038\/ki.2013.462","volume":"85","author":"A-E Decl\u00e8ves","year":"2014","unstructured":"Decl\u00e8ves A-E, Zolkipli Z, Satriano J et al (2014b) Regulation of lipid accumulation by AMK-activated kinase in high fat diet\u2013induced kidney injury. Kidney Int 85(3):611\u2013623","journal-title":"Kidney Int"},{"key":"21235_CR22","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.ijcard.2016.11.156","volume":"227","author":"L Di Lullo","year":"2017","unstructured":"Di Lullo L, Bellasi A, Russo D et al (2017) Cardiorenal acute kidney injury: epidemiology, presentation, causes, pathophysiology and treatment. Int J Cardiol 227:143\u2013150","journal-title":"Int J Cardiol"},{"issue":"22","key":"21235_CR23","doi-asserted-by":"publisher","first-page":"5747","DOI":"10.3390\/ijms20225747","volume":"20","author":"S \u0110ura\u0161evi\u0107","year":"2019","unstructured":"\u0110ura\u0161evi\u0107 S, Stojkovi\u0107 M, Bogdanovi\u0107 L et al (2019) The effects of meldonium on the renal acute ischemia\/reperfusion injury in rats. Int J Mol Sci 20(22):5747","journal-title":"Int J Mol Sci"},{"key":"21235_CR24","first-page":"16","volume":"6","author":"H Edrees","year":"2017","unstructured":"Edrees H, Elbehiry A, Elmosaad YM (2017) Hypoglycemic and anti-inflammatory effects of gold nanoparticles in streptozotocin-induced type 1 diabetes in experimental rats. Int J Diab Res 6:16\u201323","journal-title":"Int J Diab Res"},{"issue":"11","key":"21235_CR25","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1038\/nm.2507","volume":"17","author":"HK Eltzschig","year":"2011","unstructured":"Eltzschig HK, Eckle T (2011) Ischemia and reperfusion\u2014from mechanism to translation. Nat Med 17(11):1391\u20131401","journal-title":"Nat Med"},{"issue":"6","key":"21235_CR26","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1007\/s12274-014-0697-3","volume":"8","author":"I Fratoddi","year":"2015","unstructured":"Fratoddi I, Venditti I, Cametti C et al (2015) How toxic are gold nanoparticles? The State-of-the-Art Nano Research 8(6):1771\u20131799","journal-title":"The State-of-the-Art Nano Research"},{"issue":"22","key":"21235_CR27","first-page":"1","volume":"4","author":"K Fujii","year":"2019","unstructured":"Fujii K, Kubo A, Miyashita K et al (2019) Xanthine oxidase inhibitor ameliorates postischemic renal injury in mice by promoting resynthesis of adenine nucleotides. Am Soc Clin Invest 4(22):1\u201348","journal-title":"Am Soc Clin Invest"},{"issue":"1","key":"21235_CR28","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/cdd.2011.96","volume":"19","author":"L Galluzzi","year":"2012","unstructured":"Galluzzi L, Vitale I, Abrams JM et al (2012) Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ 19(1):107\u2013120","journal-title":"Cell Death Differ"},{"issue":"5","key":"21235_CR29","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1016\/j.kint.2017.05.034","volume":"92","author":"DL Galvan","year":"2017","unstructured":"Galvan DL, Green NH, Danesh FR (2017) The hallmarks of mitochondrial dysfunction in chronic kidney disease. Kidney Int 92(5):1051\u20131057","journal-title":"Kidney Int"},{"issue":"2","key":"21235_CR30","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1080\/21691401.2017.1305393","volume":"46","author":"K Golchin","year":"2018","unstructured":"Golchin K, Golchin J, Ghaderi S et al (2018) Gold nanoparticles applications: from artificial enzyme till drug delivery. Artif Cells Nanomed Biotechnol 46(2):250\u2013254","journal-title":"Artif Cells Nanomed Biotechnol"},{"issue":"1","key":"21235_CR31","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1080\/0886022X.2019.1643737","volume":"41","author":"D-J Gong","year":"2019","unstructured":"Gong D-J, Wang L, Yang Y-Y et al (2019) Diabetes aggravates renal ischemia and reperfusion injury in rats by exacerbating oxidative stress, inflammation, and apoptosis. Ren Fail 41(1):750\u2013761","journal-title":"Ren Fail"},{"issue":"33","key":"21235_CR32","doi-asserted-by":"publisher","first-page":"12338","DOI":"10.1021\/ja405371g","volume":"135","author":"L Guo","year":"2013","unstructured":"Guo L, Xu Y, Ferhan AR et al (2013) Oriented gold nanoparticle aggregation for colorimetric sensors with surprisingly high analytical figures of merit. J Am Chem Soc 135(33):12338\u201312345","journal-title":"J Am Chem Soc"},{"key":"21235_CR33","doi-asserted-by":"crossref","unstructured":"Guo Y, Yu W, Sun D et al (2015) A novel protective mechanism for mitochondrial aldehyde dehydrogenase (ALDH2) in type I diabetes-induced cardiac dysfunction: role of AMPK-regulated autophagy. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1852(2): 319\u2013331","DOI":"10.1016\/j.bbadis.2014.05.017"},{"key":"21235_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/7612182","volume":"2017","author":"P Han","year":"2017","unstructured":"Han P, Qin Z, Tang J et al (2017) RTA-408 protects kidney from ischemia-reperfusion injury in mice via activating Nrf2 and downstream GSH biosynthesis gene. Oxid Med Cell Longev 2017:1\u201310","journal-title":"Oxid Med Cell Longev"},{"issue":"1","key":"21235_CR35","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S0014-5793(03)00560-X","volume":"546","author":"DG Hardie","year":"2003","unstructured":"Hardie DG, Scott JW, Pan DA et al (2003) Management of cellular energy by the AMP-activated protein kinase system. FEBS Lett 546(1):113\u2013120","journal-title":"FEBS Lett"},{"issue":"1","key":"21235_CR36","doi-asserted-by":"publisher","first-page":"37","DOI":"10.15171\/jnp.2018.11","volume":"7","author":"A Hasanvand","year":"2018","unstructured":"Hasanvand A, Amini-Khoei H, Jahanabadi S et al (2018) Metformin attenuates streptozotocin-induced diabetic nephropathy in rats through activation of AMPK signaling pathway. J Nephropathol 7(1):37\u201342","journal-title":"J Nephropathol"},{"issue":"9","key":"21235_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0138505","volume":"10","author":"HC Hatcher","year":"2015","unstructured":"Hatcher HC, Tesfay L, Torti SV et al (2015) Cytoprotective effect of ferritin h in renal ischemia reperfusion injury. PLoS ONE 10(9):1\u201310","journal-title":"PLoS ONE"},{"key":"21235_CR38","doi-asserted-by":"crossref","unstructured":"Haupenthal DPDS, Possato JC, Zaccaron RP et al (2020) Effects of chronic treatment with gold nanoparticles on inflammatory responses and oxidative stress in Mdx mice. J Drug Target, 28(1): 46\u201354","DOI":"10.1080\/1061186X.2019.1613408"},{"issue":"5","key":"21235_CR39","doi-asserted-by":"publisher","first-page":"e0233109","DOI":"10.1371\/journal.pone.0233109","volume":"15","author":"S Herath","year":"2020","unstructured":"Herath S, Dai H, Erlich J et al (2020) Selection and validation of reference genes for normalisation of gene expression in ischaemic and toxicological studies in kidney disease. PLOS ONE 15(5):e0233109","journal-title":"PLOS ONE"},{"key":"21235_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/9783893","volume":"2017","author":"X Hong","year":"2017","unstructured":"Hong X, Zhao X, Wang G et al (2017) Luteolin treatment protects against renal ischemia-reperfusion injury in rats. Mediators Inflamm 2017:1\u201310","journal-title":"Mediators Inflamm"},{"key":"21235_CR41","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1146\/annurev-physiol-022516-034227","volume":"80","author":"BD Humphreys","year":"2018","unstructured":"Humphreys BD (2018) Mechanisms of renal fibrosis. Annu Rev Physiol 80:309\u2013326","journal-title":"Annu Rev Physiol"},{"issue":"14","key":"21235_CR42","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.2217\/nnm-2018-0009","volume":"13","author":"RM Hussein","year":"2018","unstructured":"Hussein RM, Saleh H (2018) Promising therapeutic effect of gold nanoparticles against dinitrobenzene sulfonic acid-induced colitis in rats. Nanomedicine 13(14):1657\u20131679","journal-title":"Nanomedicine"},{"issue":"1","key":"21235_CR43","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/S0300-483X(03)00003-9","volume":"187","author":"TI Jeon","year":"2003","unstructured":"Jeon TI, Hwang SG, Park NG et al (2003) Antioxidative effect of chitosan on chronic carbon tetrachloride induced hepatic injury in rats. Toxicology 187(1):67\u201373","journal-title":"Toxicology"},{"issue":"3\u20134","key":"21235_CR44","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1016\/j.fct.2011.11.028","volume":"50","author":"S-I Jeong","year":"2012","unstructured":"Jeong S-I, Kim S-J, Kwon T-H et al (2012) Schizandrin prevents damage of murine mesangial cells via blocking NADPH oxidase-induced ROS signaling in high glucose. Food Chem Toxicol 50(3\u20134):1045\u20131053","journal-title":"Food Chem Toxicol"},{"issue":"12","key":"21235_CR45","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1038\/ki.2012.261","volume":"82","author":"M Jiang","year":"2012","unstructured":"Jiang M, Wei Q, Dong G et al (2012) Autophagy in proximal tubules protects against acute kidney injury. Kidney Int 82(12):1271\u20131283","journal-title":"Kidney Int"},{"key":"21235_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bpc.2020.106457","volume":"266","author":"F Jiao","year":"2020","unstructured":"Jiao F, Sang J, Liu Z et al (2020) Effect of concentration of PEG coated gold nanoparticle on lung surfactant studied with coarse-grained molecular dynamics simulations. Biophys Chem 266:1\u201310","journal-title":"Biophys Chem"},{"issue":"1","key":"21235_CR47","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.ejphar.2007.12.011","volume":"582","author":"L Jin","year":"2008","unstructured":"Jin L, Xue H-Y, Jin L-J et al (2008) Antioxidant and pancreas-protective effect of aucubin on rats with streptozotocin-induced diabetes. Eur J Pharmacol 582(1):162\u2013167","journal-title":"Eur J Pharmacol"},{"key":"21235_CR48","doi-asserted-by":"crossref","unstructured":"Johnson JA, Johnson DA, Kraft AD et al (2008) The Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegeneration. Ann N Y Acad Sci 1147:61\u201369","DOI":"10.1196\/annals.1427.036"},{"issue":"4","key":"21235_CR49","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1097\/00041552-199307000-00014","volume":"2","author":"KJ Johnson","year":"1993","unstructured":"Johnson KJ, Weinberg JM (1993) Postischemic renal injury due to oxygen radicals. Curr Opin Nephrol Hypertens 2(4):625\u2013635","journal-title":"Curr Opin Nephrol Hypertens"},{"issue":"21","key":"21235_CR50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijms21217994","volume":"21","author":"F Juszczak","year":"2020","unstructured":"Juszczak F, Caron N, Mathew AV et al (2020) Critical role for AMPK in metabolic disease-induced chronic kidney disease. Int J Mol Sci 21(21):1\u201323","journal-title":"Int J Mol Sci"},{"issue":"7","key":"21235_CR51","doi-asserted-by":"publisher","first-page":"1832","DOI":"10.2337\/db11-0082","volume":"60","author":"P Kantharidis","year":"2011","unstructured":"Kantharidis P, Wang B, Carew RM et al (2011) Diabetes complications: the microRNA perspective. J Diabetes 60(7):1832\u20131837","journal-title":"J Diabetes"},{"issue":"9","key":"21235_CR52","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1016\/j.freeradbiomed.2009.07.035","volume":"47","author":"JW Kaspar","year":"2009","unstructured":"Kaspar JW, Niture SK, Jaiswal AK (2009) Nrf 2:INrf2 (Keap1) signaling in oxidative stress. Free Radical Biol Med 47(9):1304\u20131309","journal-title":"Free Radical Biol Med"},{"key":"21235_CR53","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1080\/21691401.2018.1446968","volume":"46","author":"MA Khan","year":"2018","unstructured":"Khan MA, Khan MJ (2018) Nano-gold displayed anti-inflammatory property via NF-kB pathways by suppressing COX-2 activity. Artificial Cells Nanomedicine Biotechnol 46:1149\u20131158","journal-title":"Artificial Cells Nanomedicine Biotechnol"},{"issue":"2","key":"21235_CR54","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.krcp.2016.02.004","volume":"35","author":"Y Kim","year":"2016","unstructured":"Kim Y, Park CW (2016) Adenosine monophosphate\u2013activated protein kinase in diabetic nephropathy. Kidney Res Clin Pract 35(2):69\u201377","journal-title":"Kidney Res Clin Pract"},{"key":"21235_CR55","doi-asserted-by":"crossref","unstructured":"Kong FY, Zhang JW, Li RF, Wang ZX, Wang WJ, Wang W (2017) Unique roles of gold nanoparticles in drug delivery, targeting and imaging applications. Molecules 22(9):1\u201313","DOI":"10.3390\/molecules22091445"},{"key":"21235_CR56","doi-asserted-by":"crossref","unstructured":"Kovac, S, Angelova, PR, Holmstr\u00f6m, KM, et al (2015) Nrf2 regulates ROS production by mitochondria and NADPH oxidase. Biochimica et Biophysica Acta (BBA) - General Subjects, 1850 (4): 794\u2013801","DOI":"10.1016\/j.bbagen.2014.11.021"},{"issue":"4","key":"21235_CR57","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.bbrc.2010.02.046","volume":"393","author":"C Lasagna-Reeves","year":"2010","unstructured":"Lasagna-Reeves C, Gonzalez-Romero D, Barria MA et al (2010) Bioaccumulation and toxicity of gold nanoparticles after repeated administration in mice. Biochem Biophys Res Commun 393(4):649\u2013655","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"21235_CR58","first-page":"232","volume":"15","author":"G Lepore","year":"2002","unstructured":"Lepore G, Bruttomesso D, Nosari I et al (2002) Glycaemic control and microvascular complications in a large cohort of Italian type 1 diabetic out-patients. Diabetes Nutr Metab 15(4):232\u2013239","journal-title":"Diabetes Nutr Metab"},{"issue":"4","key":"21235_CR59","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1159\/000487735","volume":"45","author":"J Li","year":"2018","unstructured":"Li J, Li L, Wang S et al (2018) Resveratrol alleviates inflammatory responses and oxidative stress in rat kidney ischemia-reperfusion injury and H2O2-induced NRK-52E cells via the Nrf2\/TLR4\/NF-\u03baB pathway. J Cell Physiol Biochem 45(4):1677\u20131689","journal-title":"J Cell Physiol Biochem"},{"issue":"11","key":"21235_CR60","doi-asserted-by":"publisher","first-page":"2392","DOI":"10.1039\/C7MB00167C","volume":"13","author":"L Li","year":"2017","unstructured":"Li L, Wang C, Yang H et al (2017) Metabolomics reveal mitochondrial and fatty acid metabolism disorders that contribute to the development of DKD in T2DM patients. Mol BioSyst 13(11):2392\u20132400","journal-title":"Mol BioSyst"},{"issue":"6","key":"21235_CR61","doi-asserted-by":"publisher","first-page":"2461","DOI":"10.1159\/000475915","volume":"41","author":"Q Ling","year":"2017","unstructured":"Ling Q, Yu X, Wang T et al (2017) Roles of the exogenous H2S-mediated SR-A signaling pathway in renal ischemia\/ reperfusion injury in regulating endoplasmic reticulum stress-induced autophagy in a rat model. Cell Physiol Biochem 41(6):2461\u20132474","journal-title":"Cell Physiol Biochem"},{"issue":"25","key":"21235_CR62","doi-asserted-by":"publisher","first-page":"6574","DOI":"10.1016\/j.biomaterials.2010.05.009","volume":"31","author":"J Lipka","year":"2010","unstructured":"Lipka J, Semmler-Behnke M, Sperling RA et al (2010) Biodistribution of PEG-modified gold nanoparticles following intratracheal instillation and intravenous injection. Biomaterials 31(25):6574\u20136581","journal-title":"Biomaterials"},{"issue":"2","key":"21235_CR63","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/j.bbrc.2019.11.105","volume":"522","author":"S-S Liu","year":"2020","unstructured":"Liu S-S, Chen Y-Y, Wang S-X et al (2020) Protective effect of dabrafenib on renal ischemia-reperfusion injury in vivo and in vitro. Biochem Biophys Res Commun 522(2):395\u2013401","journal-title":"Biochem Biophys Res Commun"},{"key":"21235_CR64","doi-asserted-by":"publisher","first-page":"17023","DOI":"10.1038\/sigtrans.2017.23","volume":"2","author":"T Liu","year":"2017","unstructured":"Liu T, Zhang L, Joo D et al (2017) NF-\u03baB signaling in inflammation. Signal Transduct Target Ther 2:17023\u201317033","journal-title":"Signal Transduct Target Ther"},{"issue":"9","key":"21235_CR65","doi-asserted-by":"publisher","first-page":"2780","DOI":"10.1021\/ja711298b","volume":"130","author":"X Liu","year":"2008","unstructured":"Liu X, Dai Q, Austin L et al (2008) A one-step homogeneous immunoassay for cancer biomarker detection using gold nanoparticle probes coupled with dynamic light scattering. J Am Chem Soc 130(9):2780\u20132782","journal-title":"J Am Chem Soc"},{"issue":"12","key":"21235_CR66","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1038\/nrneph.2011.149","volume":"7","author":"Y Liu","year":"2011","unstructured":"Liu Y (2011) Cellular and molecular mechanisms of renal fibrosis. Nat Rev Nephrol 7(12):684\u2013696","journal-title":"Nat Rev Nephrol"},{"key":"21235_CR67","doi-asserted-by":"crossref","unstructured":"Lv W, Booz GW, Fan F, Wang Y, Roman RJ (2018) Oxidative stress and renal fibrosis: recent insights for the development of novel therapeutic strategies. Front Physiol 9:1\u201311","DOI":"10.3389\/fphys.2018.00105"},{"issue":"5","key":"21235_CR68","doi-asserted-by":"publisher","first-page":"353","DOI":"10.7150\/ijms.8.353","volume":"8","author":"X Lv","year":"2011","unstructured":"Lv X, Wang Z-M, Huang S-D et al (2011) Emulsified isoflurane preconditioning reduces lung injury induced by hepatic ischemia\/reperfusion in rats. J Int J Med Sci 8(5):353\u2013361","journal-title":"J Int J Med Sci"},{"issue":"4","key":"21235_CR69","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1002\/med.21257","volume":"32","author":"S Magesh","year":"2012","unstructured":"Magesh S, Chen Y, Hu L (2012) Small molecule modulators of K eap1-N rf2-ARE pathway as potential preventive and therapeutic agents. Med Res Rev 32(4):687\u2013726","journal-title":"Med Res Rev"},{"issue":"2","key":"21235_CR70","first-page":"20","volume":"4","author":"M Malek","year":"2015","unstructured":"Malek M, Nematbakhsh M (2015) Renal ischemia\/reperfusion injury; from pathophysiology to treatment. J Renal Inj Prev 4(2):20\u201327","journal-title":"J Renal Inj Prev"},{"issue":"4","key":"21235_CR71","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1021\/ac702037y","volume":"80","author":"CD Medley","year":"2008","unstructured":"Medley CD, Smith JE, Tang Z et al (2008) Gold nanoparticle-based colorimetric assay for the direct detection of cancerous cells. Anal Chem 80(4):1067\u20131072","journal-title":"Anal Chem"},{"issue":"1","key":"21235_CR72","doi-asserted-by":"publisher","first-page":"F78","DOI":"10.1152\/ajprenal.00077.2007","volume":"293","author":"JM Mej\u00eda-Vilet","year":"2007","unstructured":"Mej\u00eda-Vilet JM, Ram\u00edrez V, Cruz C et al (2007) Renal ischemia-reperfusion injury is prevented by the mineralocorticoid receptor blocker spironolactone. Am J Physiol Renal Physiol 293(1):F78\u2013F86","journal-title":"Am J Physiol Renal Physiol"},{"issue":"4","key":"21235_CR73","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1046\/j.1523-1755.2002.00284.x","volume":"61","author":"J Melin","year":"2002","unstructured":"Melin J, Hellberg O, Larsson E et al (2002) Protective effect of insulin on ischemic renal injury in diabetes mellitus. Kidney Int 61(4):1383\u20131392","journal-title":"Kidney Int"},{"issue":"3\/4","key":"21235_CR74","doi-asserted-by":"publisher","first-page":"90","DOI":"10.2307\/1412308","volume":"14","author":"A Meyer","year":"1903","unstructured":"Meyer A (1903) An attempt at analysis of the neurotic constitution. Am J Psychol 14(3\/4):90\u2013103","journal-title":"Am J Psychol"},{"issue":"4","key":"21235_CR75","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1089\/ars.2012.5116","volume":"20","author":"C Mo","year":"2014","unstructured":"Mo C, Wang L, Zhang J et al (2014) The crosstalk between Nrf2 and AMPK signal pathways is important for the anti-inflammatory effect of berberine in LPS-stimulated macrophages and endotoxin-shocked mice. Antioxid Redox Signal 20(4):574\u2013588","journal-title":"Antioxid Redox Signal"},{"key":"21235_CR76","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/j.msec.2017.03.283","volume":"77","author":"AP Muller","year":"2017","unstructured":"Muller AP, Ferreira GK, Pires AJ et al (2017) Gold nanoparticles prevent cognitive deficits, oxidative stress and inflammation in a rat model of sporadic dementia of Alzheimer\u2019s type. Mater Sci Eng, C 77:476\u2013483","journal-title":"Mater Sci Eng, C"},{"issue":"2","key":"21235_CR77","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/S0014-5793(03)00517-9","volume":"546","author":"K Nakaso","year":"2003","unstructured":"Nakaso K, Yano H, Fukuhara Y et al (2003) PI3K is a key molecule in the Nrf2-mediated regulation of antioxidative proteins by hemin in human neuroblastoma cells. FEBS Lett 546(2):181\u2013184","journal-title":"FEBS Lett"},{"key":"21235_CR78","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/S0006-291X(72)80218-3","volume":"46","author":"M Nishikimi","year":"1972","unstructured":"Nishikimi M, Appaji N, Yagi K (1972) The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen. Biochem Biophys Res Commun 46:849\u2013854","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"21235_CR79","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1681\/ASN.2013090990","volume":"26","author":"L Nordquist","year":"2015","unstructured":"Nordquist L, Friederich-Persson M, Fasching A et al (2015) Activation of hypoxia-inducible factors prevents diabetic nephropathy. J Journal of the American Society of Nephrology 26(2):328\u2013338","journal-title":"J Journal of the American Society of Nephrology"},{"key":"21235_CR80","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","volume":"95","author":"H Ohkawa","year":"1979","unstructured":"Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351\u2013358","journal-title":"Anal Biochem"},{"key":"21235_CR81","first-page":"74","volume":"70","author":"DE Paglia","year":"1967","unstructured":"Paglia DE (1967) Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidases. J Lab Clin Med 70:74\u201377","journal-title":"J Lab Clin Med"},{"key":"21235_CR82","first-page":"632","volume":"42","author":"MS Paller","year":"1994","unstructured":"Paller MS (1994) The cell biology of reperfusion injury in the kidney. J Investig Med 42:632\u2013639","journal-title":"J Investig Med"},{"issue":"11","key":"21235_CR83","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.1002\/smll.200700378","volume":"3","author":"Y Pan","year":"2007","unstructured":"Pan Y, Neuss S, Leifert A et al (2007) Size-dependent cytotoxicity of gold nanoparticles. Small 3(11):1941\u20131949","journal-title":"Small"},{"key":"21235_CR84","first-page":"1","volume":"2018","author":"JH Park","year":"2018","unstructured":"Park JH, Jun JH, Shim J-K et al (2018) Effects of post ischemia-reperfusion treatment with trimetazidine on renal injury in rats: insights on delayed renal fibrosis progression. Oxid Med Cell Longev 2018:1\u201310","journal-title":"Oxid Med Cell Longev"},{"key":"21235_CR85","doi-asserted-by":"publisher","first-page":"52282","DOI":"10.1074\/jbc.M407629200","volume":"279","author":"KM Park","year":"2004","unstructured":"Park KM (2004) Testosterone is responsible for enhanced susceptibility of males to ischemic renal injury. J Biol Chem 279:52282\u201352292","journal-title":"J Biol Chem"},{"key":"21235_CR86","doi-asserted-by":"publisher","first-page":"7793","DOI":"10.2147\/IJN.S231353","volume":"14","author":"AK Patlolla","year":"2019","unstructured":"Patlolla AK, Shinde KK, Tchounwou PB (2019) A comparison of poly-ethylene-glycol-coated and uncoated gold nanoparticle-mediated hepatotoxicity and oxidative stress in Sprague-Dawley rats. Int J Nanomed 14:7793\u20137794","journal-title":"Int J Nanomed"},{"issue":"1","key":"21235_CR87","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1038\/ki.2014.226","volume":"87","author":"J Peng","year":"2015","unstructured":"Peng J, Li X, Zhang D et al (2015) Hyperglycemia, p53, and mitochondrial pathway of apoptosis are involved in the susceptibility of diabetic models to ischemic acute kidney injury. Kidney Int 87(1):137\u2013150","journal-title":"Kidney Int"},{"issue":"8","key":"21235_CR88","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1002\/dmrr.893","volume":"24","author":"JC Pickup","year":"2008","unstructured":"Pickup JC, Zhi ZL, Khan F et al (2008) Nanomedicine and its potential in diabetes research and practice. J Diabetes Metab Res Rev 24(8):604\u2013610","journal-title":"J Diabetes Metab Res Rev"},{"issue":"2","key":"21235_CR89","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1152\/ajpendo.00314.2018","volume":"316","author":"MV Pinti","year":"2019","unstructured":"Pinti MV, Fink GK, Hathaway QA et al (2019) Mitochondrial dysfunction in type 2 diabetes mellitus: an organ-based analysis. Am J Physiol Endocrinol Metab 316(2):268\u2013285","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"1\u20134","key":"21235_CR90","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1159\/000363717","volume":"127","author":"D Portilla","year":"2014","unstructured":"Portilla D (2014) Apoptosis, fibrosis and senescence. Nephron Clin Pract 127(1\u20134):65\u201369","journal-title":"Nephron Clin Pract"},{"key":"21235_CR91","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.phrs.2016.07.016","volume":"111","author":"M Qi","year":"2016","unstructured":"Qi M, Yin L, Xu L et al (2016) Dioscin alleviates lipopolysaccharide-induced inflammatory kidney injury via the microRNA let-7i\/TLR4\/MyD88 signaling pathway. J Pharmacol Res 111:509\u2013522","journal-title":"J Pharmacol Res"},{"issue":"4","key":"21235_CR92","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1213\/ANE.0000000000002131","volume":"125","author":"L Rahmania","year":"2017","unstructured":"Rahmania L, Orbegozo D, Su F et al (2017) Administration of tetrahydrobiopterin (BH4) protects the renal microcirculation from ischemia and reperfusion injury. J Anesth Analg 125(4):1253\u20131260","journal-title":"J Anesth Analg"},{"issue":"2","key":"21235_CR93","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.addr.2011.08.006","volume":"64","author":"S Rana","year":"2012","unstructured":"Rana S, Bajaj A, Mout R et al (2012) Monolayer coated gold nanoparticles for delivery applications. Adv Drug Deliv Rev 64(2):200\u2013216","journal-title":"Adv Drug Deliv Rev"},{"issue":"5","key":"21235_CR94","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1163\/156856206776986279","volume":"17","author":"KC Remant Bahadur","year":"2006","unstructured":"Remant Bahadur KC, Aryal S, Bhattarai SR et al (2006) Stabilization of gold nanoparticles by hydrophobically-modified polycations. J Biomater Sci Polym Ed 17(5):579\u2013589","journal-title":"J Biomater Sci Polym Ed"},{"key":"21235_CR95","doi-asserted-by":"publisher","first-page":"5841","DOI":"10.2147\/IJN.S141839","volume":"12","author":"H Rizwan","year":"2017","unstructured":"Rizwan H, Mohanta J, Si S et al (2017) Gold nanoparticles reduce high glucose-induced oxidative-nitrosative stress regulated inflammation and apoptosis via tuberin-mTOR\/NF-\u03baB pathways in macrophages. Int J Nanomed 12:5841\u20135862","journal-title":"Int J Nanomed"},{"issue":"1","key":"21235_CR96","doi-asserted-by":"publisher","first-page":"55","DOI":"10.15283\/ijsc.2013.6.1.55","volume":"6","author":"EM Sadek","year":"2013","unstructured":"Sadek EM, Afifi NM, Elfattah LI et al (2013) Histological study on effect of mesenchymal stem cell therapy on experimental renal injury induced by ischemia\/reperfusion in male albino rat. Int J Stem Cells 6(1):55\u201366","journal-title":"Int J Stem Cells"},{"issue":"3","key":"21235_CR97","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1097\/MNH.0b013e328344c3d4","volume":"20","author":"C Schrimpf","year":"2011","unstructured":"Schrimpf C, Duffield JS (2011) Mechanisms of fibrosis: the role of the pericyte. Curr Opin Nephrol Hypertens 20(3):297\u2013305","journal-title":"Curr Opin Nephrol Hypertens"},{"issue":"5","key":"21235_CR98","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/S0031-6989(81)80074-4","volume":"13","author":"KR Shanmugasundaram","year":"1981","unstructured":"Shanmugasundaram KR, Panneerselvam C, Samudram P et al (1981) The insulinotropic activity of Gymnema sylvestre, R.Br. an Indian medical herb used in controlling diabetes mellitus. Pharmacol Res Commun 13(5):475\u2013486","journal-title":"Pharmacol Res Commun"},{"issue":"5","key":"21235_CR99","doi-asserted-by":"publisher","first-page":"8311","DOI":"10.1002\/jcb.28114","volume":"120","author":"Y Shen","year":"2019","unstructured":"Shen Y, Zhao Y, Wang L et al (2019) MicroRNA-194 overexpression protects against hypoxia\/reperfusion-induced HK-2 cell injury through direct targeting Rheb. J Cell Biochem 120(5):8311\u20138318","journal-title":"J Cell Biochem"},{"key":"21235_CR100","doi-asserted-by":"crossref","unstructured":"Si S, Pal A, Mohanta J et al (2017) Gold nanostructure materials in diabetes management, 50: 1-10","DOI":"10.1088\/1361-6463\/aa5e21"},{"key":"21235_CR101","first-page":"236","volume":"230","author":"R Stiufiuc","year":"2013","unstructured":"Stiufiuc R, Iacovita C, Nicoara R et al (2013) One-step synthesis of PEGylated gold nanoparticles with tunable surface charge. J Nanomater 230:236\u2013029","journal-title":"J Nanomater"},{"issue":"3","key":"21235_CR102","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1002\/smll.201201528","volume":"9","author":"VV Sumbayev","year":"2013","unstructured":"Sumbayev VV, Yasinska IM, Garcia CP et al (2013) Gold nanoparticles downregulate interleukin-1\u03b2-induced pro-inflammatory responses. Small 9(3):472\u2013477","journal-title":"Small"},{"key":"21235_CR103","doi-asserted-by":"crossref","unstructured":"Turkevich J, Stevenson PC, Hillier JJDOTFS (1951) A study of the nucleation and growth processes in the synthesis of colloidal gold, 11: 55-75","DOI":"10.1039\/df9511100055"},{"issue":"15","key":"21235_CR104","doi-asserted-by":"publisher","first-page":"2996","DOI":"10.1128\/MCB.00225-13","volume":"33","author":"A Uruno","year":"2013","unstructured":"Uruno A, Furusawa Y, Yagishita Y et al (2013) The Keap1-Nrf2 system prevents onset of diabetes mellitus. Mol Cell Biol 33(15):2996\u20133010","journal-title":"Mol Cell Biol"},{"key":"21235_CR105","doi-asserted-by":"publisher","first-page":"3380","DOI":"10.2741\/3460","volume":"14","author":"B Viollet","year":"2009","unstructured":"Viollet B, Lantier L, Devin-Leclerc J et al (2009) Targeting the AMPK pathway for the treatment of type 2 diabetes. Front Biosci (landmark Edition) 14:3380\u20133400","journal-title":"Front Biosci (landmark Edition)"},{"issue":"2","key":"21235_CR106","doi-asserted-by":"publisher","first-page":"277","DOI":"10.5455\/2319-2003.ijbcp20140405","volume":"3","author":"MA Woldu","year":"2014","unstructured":"Woldu MA, Lenjisa JL (2014) Nanoparticles and the new era in diabetes management. Int J Basic Clin Pharmacol 3(2):277\u2013284","journal-title":"Int J Basic Clin Pharmacol"},{"key":"21235_CR107","first-page":"1","volume":"2013","author":"Y Wu","year":"2013","unstructured":"Wu Y, Zhang J, Liu F et al (2013) Protective effects of HBSP on ischemia reperfusion and cyclosporine A induced renal injury. Clin Dev Immunol 2013:1\u201310","journal-title":"Clin Dev Immunol"},{"issue":"15","key":"21235_CR108","doi-asserted-by":"publisher","first-page":"24154","DOI":"10.18632\/oncotarget.16530","volume":"8","author":"D Xie","year":"2017","unstructured":"Xie D, Xu Y, Jing W et al (2017) Berberine nanoparticles protects tubular epithelial cells from renal ischemia-reperfusion injury. Oncotarget 8(15):24154\u201324162","journal-title":"Oncotarget"},{"issue":"2","key":"21235_CR109","doi-asserted-by":"publisher","first-page":"605","DOI":"10.2337\/db13-0909","volume":"63","author":"Y Yagishita","year":"2014","unstructured":"Yagishita Y, Fukutomi T, Sugawara A et al (2014) Nrf2 protects pancreatic \u03b2-cells from oxidative and nitrosative stress in diabetic model mice. J Diabetes 63(2):605\u2013618","journal-title":"J Diabetes"},{"issue":"1","key":"21235_CR110","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.nantod.2014.02.004","volume":"9","author":"W Yang","year":"2014","unstructured":"Yang W, Liu S, Bai T et al (2014) Poly(carboxybetaine) nanomaterials enable long circulation and prevent polymer-specific antibody production. Nano Today 9(1):10\u201316","journal-title":"Nano Today"},{"issue":"4","key":"21235_CR111","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1152\/ajprenal.00181.2019","volume":"317","author":"Y-Y Yang","year":"2019","unstructured":"Yang Y-Y, Gong D-J, Zhang J-J et al (2019) Diabetes aggravates renal ischemia-reperfusion injury by repressing mitochondrial function and PINK1\/Parkin-mediated mitophagy. Am J Physiol Renal Physiol 317(4):852\u2013864","journal-title":"Am J Physiol Renal Physiol"},{"issue":"1","key":"21235_CR112","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1479-5876-11-24","volume":"11","author":"W Yu","year":"2013","unstructured":"Yu W, Sheng M, Xu R et al (2013) Berberine protects human renal proximal tubular cells from hypoxia\/reoxygenation injury via inhibiting endoplasmic reticulum and mitochondrial stress pathways. J Transl Med 11(1):1\u201310","journal-title":"J Transl Med"},{"key":"21235_CR113","doi-asserted-by":"crossref","unstructured":"Zamora-Justo JA, Abrica-Gonz\u00e1lez P, V\u00e1zquez-Mart\u00ednez GR, Mu\u00f1oz-Diosdado A, Balderas-L\u00f3pez JA, Ib\u00e1\u00f1ez-Hern\u00e1ndez M (2019) Polyethylene glycol-coated gold nanoparticles as DNA and atorvastatin delivery systems and cytotoxicity evaluation. J Nanomater 13:1\u201311","DOI":"10.1155\/2019\/5982047"},{"issue":"22","key":"21235_CR114","doi-asserted-by":"publisher","first-page":"8137","DOI":"10.1128\/MCB.23.22.8137-8151.2003","volume":"23","author":"DD Zhang","year":"2003","unstructured":"Zhang DD, Hannink M (2003) Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress. Mol Cell Biol 23(22):8137\u20138151","journal-title":"Mol Cell Biol"},{"key":"21235_CR115","doi-asserted-by":"publisher","first-page":"2071","DOI":"10.2147\/IJN.S21657","volume":"6","author":"XD Zhang","year":"2011","unstructured":"Zhang XD, Wu D, Shen X et al (2011) Size-dependent in vivo toxicity of PEG-coated gold nanoparticles. Int J Nanomed 6:2071\u20132081","journal-title":"Int J Nanomed"},{"key":"21235_CR116","doi-asserted-by":"publisher","first-page":"771","DOI":"10.2147\/IJN.S8428","volume":"5","author":"XD Zhang","year":"2010","unstructured":"Zhang XD, Wu HY, Wu D et al (2010) Toxicologic effects of gold nanoparticles in vivo by different administration routes. Int J Nanomedicine 5:771\u2013781","journal-title":"Int J Nanomedicine"},{"issue":"3","key":"21235_CR117","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1007\/s10557-010-6240-1","volume":"24","author":"ZQ Zhao","year":"2010","unstructured":"Zhao ZQ (2010) Postconditioning in reperfusion injury: a status report. Cardiovasc Drugs Ther 24(3):265\u2013279","journal-title":"Cardiovasc Drugs Ther"},{"issue":"7","key":"21235_CR118","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1007\/s11064-019-02776-7","volume":"44","author":"Y Zheng","year":"2019","unstructured":"Zheng Y, Wu Y, Liu Y et al (2019) Intrinsic effects of gold nanoparticles on oxygen\u2013glucose deprivation\/reperfusion injury in rat cortical neurons. Neurochem Res 44(7):1549\u20131566","journal-title":"Neurochem Res"},{"issue":"6","key":"21235_CR119","doi-asserted-by":"publisher","first-page":"2364","DOI":"10.1159\/000452506","volume":"39","author":"J Zhu","year":"2016","unstructured":"Zhu J, Yao K, Wang Q et al (2016) Ischemic postconditioning-regulated miR-499 protects the rat heart against ischemia\/reperfusion injury by inhibiting apoptosis through PDCD4. Cell Physiol Biochem 39(6):2364\u20132380","journal-title":"Cell Physiol Biochem"},{"key":"21235_CR120","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1146\/annurev-med-050214-013407","volume":"67","author":"A Zuk","year":"2016","unstructured":"Zuk A, Bonventre JV (2016) Acute kidney injury. J Annu Rev Med 67:293\u2013307","journal-title":"J Annu Rev Med"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-022-21235-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11356-022-21235-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-022-21235-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T04:28:46Z","timestamp":1666153726000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11356-022-21235-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,10]]},"references-count":120,"journal-issue":{"issue":"51","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["21235"],"URL":"https:\/\/doi.org\/10.1007\/s11356-022-21235-5","relation":{},"ISSN":["0944-1344","1614-7499"],"issn-type":[{"value":"0944-1344","type":"print"},{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,10]]},"assertion":[{"value":"18 March 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The experimental protocol was approved by the Institutional Animal Care and Use Committee (IACUC), Faculty of Science, Cairo University (Egypt) (CUFS\/I\/F\/PHY\/66\/18). All the experimental procedures were done following the international guidelines Guide for Care and Use of Laboratory Animals.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors drafted this work, revised it critically for important intellectual content, and approved the version to be published.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}