{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T09:52:21Z","timestamp":1774432341614,"version":"3.50.1"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"56","license":[{"start":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T00:00:00Z","timestamp":1657065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T00:00:00Z","timestamp":1657065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073504"],"award-info":[{"award-number":["82073504"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["2017GXNSFGA198003"],"award-info":[{"award-number":["2017GXNSFGA198003"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1007\/s11356-022-21653-5","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T05:02:40Z","timestamp":1657083760000},"page":"85103-85113","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Metal mixtures with longitudinal changes in lipid\u00a0profiles: findings from the manganese-exposed workers healthy cohort"],"prefix":"10.1007","volume":"29","author":[{"given":"Xiaoting","family":"Ge","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guohong","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junxiu","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Bao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuming","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunfeng","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9866-7724","authenticated-orcid":false,"given":"Xiaobo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,7,6]]},"reference":[{"key":"21653_CR1","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1007\/s12011-018-1352-8","volume":"187","author":"F Ates Alkan","year":"2019","unstructured":"Ates Alkan F, Karis D, Cakmak G, Ercan AM (2019) Analysis of the relationship between hemorheologic parameters, aluminum, manganese, and selenium in smokers. Biol Trace Elem Res 187:22\u201331","journal-title":"Biol Trace Elem Res"},{"key":"21653_CR2","doi-asserted-by":"publisher","first-page":"15606","DOI":"10.1038\/srep15606","volume":"5","author":"J Bai","year":"2015","unstructured":"Bai J, Xun P, Morris S, Jacobs DR Jr, Liu K, He K (2015) Chromium exposure and incidence of metabolic syndrome among American young adults over a 23-year follow-up: the CARDIA Trace Element Study. Sci Rep 5:15606","journal-title":"Sci Rep"},{"key":"21653_CR3","first-page":"732","volume":"29","author":"LT Bell","year":"1973","unstructured":"Bell LT, Hurley LS (1973) Ultrastructural effects of manganese deficiency in liver, heart, kidney, and pancreas of mice. Lab Invest 29:732\u2013736","journal-title":"Lab Invest"},{"key":"21653_CR4","doi-asserted-by":"publisher","first-page":"2464","DOI":"10.2337\/dc11-0888","volume":"34","author":"S Bhasin","year":"2011","unstructured":"Bhasin S, Jasjua GK, Pencina M, D\u2019Agostino R Sr, Coviello AD, Vasan RS, Travison TG (2011) Sex hormone-binding globulin, but not testosterone, is associated prospectively and independently with incident metabolic syndrome in men: the framingham heart study. Diabetes Care 34:2464\u20132470","journal-title":"Diabetes Care"},{"key":"21653_CR5","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1093\/biostatistics\/kxu058","volume":"16","author":"JF Bobb","year":"2015","unstructured":"Bobb JF, Valeri L, Claus Henn B, Christiani DC, Wright RO, Mazumdar M, Godleski JJ, Coull BA (2015) Bayesian kernel machine regression for estimating the health effects of multi-pollutant mixtures. Biostatistics 16:493\u2013508","journal-title":"Biostatistics"},{"key":"21653_CR6","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1002\/mnfr.201200758","volume":"57","author":"J Bornhorst","year":"2013","unstructured":"Bornhorst J, Meyer S, Weber T, Boker C, Marschall T, Mangerich A, Beneke S, Burkle A, Schwerdtle T (2013) Molecular mechanisms of Mn induced neurotoxicity: RONS generation, genotoxicity, and DNA-damage response. Mol Nutr Food Res 57:1255\u20131269","journal-title":"Mol Nutr Food Res"},{"key":"21653_CR7","doi-asserted-by":"crossref","unstructured":"Bryzgalova G, Gao H, Ahren B, Zierath JR, Galuska D, Steiler TL, Dahlman-Wright K, Nilsson S, Gustafsson JA, Efendic S, Khan A (2006) Evidence that oestrogen receptor-alpha plays an important role in the regulation of glucose homeostasis in mice: insulin sensitivity in the liver. Diabetologia 49:588\u2013597","DOI":"10.1007\/s00125-005-0105-3"},{"key":"21653_CR8","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.envres.2018.10.022","volume":"168","author":"CM Bulka","year":"2019","unstructured":"Bulka CM, Persky VW, Daviglus ML, Durazo-Arvizu RA, Argos M (2019) Multiple metal exposures and metabolic syndrome: a cross-sectional analysis of the National Health and Nutrition Examination Survey 2011\u20132014. Environ Res 168:397\u2013405","journal-title":"Environ Res"},{"key":"21653_CR9","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.1016\/j.clnu.2019.08.033","volume":"39","author":"L Chen","year":"2020","unstructured":"Chen L, Guo Q, Wang Q, Luo C, Chen S, Wen S, Tan A, Yang W, Bao W, Hu FB, Liu L (2020) Association between plasma strontium, a bone-seeking element, and type 2 diabetes mellitus. Clin Nutr 39:2151\u20132157","journal-title":"Clin Nutr"},{"key":"21653_CR10","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.jtemb.2018.07.019","volume":"50","author":"H Cheng","year":"2018","unstructured":"Cheng H, Xia B, Su C, Chen K, Chen X, Chen P, Zou Y, Yang X (2018) PI3K\/Akt signaling pathway and Hsp70 activate in hippocampus of rats with chronic manganese sulfate exposure. J Trace Elem Med Biol 50:332\u2013338","journal-title":"J Trace Elem Med Biol"},{"key":"21653_CR11","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/j.1467-9868.2009.00723.x","volume":"72","author":"H Chun","year":"2010","unstructured":"Chun H, Keles S (2010) Sparse partial least squares regression for simultaneous dimension reduction and variable selection. J R Stat Soc Series B Stat Methodol 72:3\u201325","journal-title":"J R Stat Soc Series B Stat Methodol"},{"key":"21653_CR12","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1016\/S0140-6736(20)30752-2","volume":"396","author":"GBDRF Collaborators","year":"2020","unstructured":"GBDRF Collaborators (2020) Global burden of 87 risk factors in 204 countries and territories, 1990\u20132019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet 396:1223\u20131249","journal-title":"Lancet"},{"key":"21653_CR13","doi-asserted-by":"publisher","first-page":"e011433","DOI":"10.1161\/JAHA.118.011433","volume":"8","author":"MS Duncan","year":"2019","unstructured":"Duncan MS, Vasan RS, Xanthakis V (2019) Trajectories of blood lipid concentrations over the adult life course and risk of cardiovascular disease and all-cause mortality: observations from the Framingham Study over 35 years. J Am Heart Assoc 8:e011433","journal-title":"J Am Heart Assoc"},{"key":"21653_CR14","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.jtemb.2009.03.006","volume":"23","author":"M Ghayour-Mobarhan","year":"2009","unstructured":"Ghayour-Mobarhan M, Shapouri-Moghaddam A, Azimi-Nezhad M, Esmaeili H, Parizadeh SM, Safarian M, Kazemi-Bajestani SM, Khodaei GH, Hosseini SJ, Parizadeh SM, Ferns GA (2009) The relationship between established coronary risk factors and serum copper and zinc concentrations in a large Persian cohort. J Trace Elem Med Biol 23:167\u2013175","journal-title":"J Trace Elem Med Biol"},{"key":"21653_CR15","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1161\/CIRCULATIONAHA.105.552737","volume":"113","author":"DC Goff Jr","year":"2006","unstructured":"Goff DC Jr, Bertoni AG, Kramer H, Bonds D, Blumenthal RS, Tsai MY, Psaty BM (2006) Dyslipidemia prevalence, treatment, and control in the Multi-Ethnic Study of Atherosclerosis (MESA): gender, ethnicity, and coronary artery calcium. Circulation 113:647\u2013656","journal-title":"Circulation"},{"key":"21653_CR16","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1177\/2047487312452965","volume":"20","author":"R Haring","year":"2013","unstructured":"Haring R, Volzke H, Spielhagen C, Nauck M, Wallaschofski H (2013) The role of sex hormone-binding globulin and testosterone in the risk of incident metabolic syndrome. Eur J Prev Cardiol 20:1061\u20131068","journal-title":"Eur J Prev Cardiol"},{"key":"21653_CR17","doi-asserted-by":"publisher","first-page":"151327","DOI":"10.1016\/j.scitotenv.2021.151327","volume":"811","author":"J He","year":"2022","unstructured":"He J, Ge X, Cheng H, Bao Y, Feng X, Zan G, Wang F, Zou Y, Yang X (2022) Sex-specific associations of exposure to metal mixtures with telomere length change: results from an 8-year longitudinal study. Sci Total Environ 811:151327","journal-title":"Sci Total Environ"},{"key":"21653_CR18","doi-asserted-by":"publisher","first-page":"126706","DOI":"10.1016\/j.jtemb.2020.126706","volume":"64","author":"P Heitland","year":"2021","unstructured":"Heitland P, Koster HD (2021) Human biomonitoring of 73 elements in blood, serum, erythrocytes and urine. J Trace Elem Med Biol 64:126706","journal-title":"J Trace Elem Med Biol"},{"key":"21653_CR19","first-page":"35","volume":"42","author":"K Helgeland","year":"1982","unstructured":"Helgeland K, Haider T, Jonsen J (1982) Copper and zinc in human serum in Norway. Relationship to geography, sex and age. Scand J Clin Lab Invest 42:35\u201339","journal-title":"Scand J Clin Lab Invest"},{"key":"21653_CR20","doi-asserted-by":"crossref","unstructured":"Huang Q, Jiang H, Zhang B, Wang H, Jia X, Huang F, Wang L, Wang Z (2019) Threshold-effect association of dietary cholesterol intake with dyslipidemia in chinese adults: results from the China Health and Nutrition Survey in 2015. Nutrients 11","DOI":"10.3390\/nu11122885"},{"key":"21653_CR21","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.neuro.2006.08.005","volume":"28","author":"Y Jiang","year":"2007","unstructured":"Jiang Y, Zheng W, Long L, Zhao W, Li X, Mo X, Lu J, Fu X, Li W, Liu S, Long Q, Huang J, Pira E (2007) Brain magnetic resonance imaging and manganese concentrations in red blood cells of smelting workers: search for biomarkers of manganese exposure. Neurotoxicology 28:126\u2013135","journal-title":"Neurotoxicology"},{"key":"21653_CR22","doi-asserted-by":"publisher","first-page":"131497","DOI":"10.1016\/j.chemosphere.2021.131497","volume":"285","author":"Q Jiang","year":"2021","unstructured":"Jiang Q, Xiao Y, Long P, Li W, Yu Y, Liu Y, Liu K, Zhou L, Wang H, Yang H, Li X, He M, Wu T, Yuan Y (2021) Associations of plasma metal concentrations with incident dyslipidemia: prospective findings from the Dongfeng-Tongji cohort. Chemosphere 285:131497","journal-title":"Chemosphere"},{"key":"21653_CR23","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.atherosclerosis.2004.05.018","volume":"176","author":"JL Johnson","year":"2004","unstructured":"Johnson JL, Slentz CA, Duscha BD, Samsa GP, McCartney JS, Houmard JA, Kraus WE (2004) Gender and racial differences in lipoprotein subclass distributions: the STRRIDE study. Atherosclerosis 176:371\u2013377","journal-title":"Atherosclerosis"},{"key":"21653_CR24","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1093\/toxsci\/kft130","volume":"135","author":"MR Karim","year":"2013","unstructured":"Karim MR, Rahman M, Islam K, Mamun AA, Hossain S, Hossain E, Aziz A, Yeasmin F, Agarwal S, Hossain MI, Saud ZA, Nikkon F, Hossain M, Mandal A, Jenkins RO, Haris PI, Miyataka H, Himeno S, Hossain K (2013) Increases in oxidized low-density lipoprotein and other inflammatory and adhesion molecules with a concomitant decrease in high-density lipoprotein in the individuals exposed to arsenic in Bangladesh. Toxicol Sci 135:17\u201325","journal-title":"Toxicol Sci"},{"key":"21653_CR25","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.envint.2018.05.033","volume":"118","author":"CC Kuo","year":"2018","unstructured":"Kuo CC, Su PH, Sun CW, Liu HJ, Chang CL, Wang SL (2018) Early-life arsenic exposure promotes atherogenic lipid metabolism in adolescence: a 15-year birth cohort follow-up study in central Taiwan. Environ Int 118:97\u2013105","journal-title":"Environ Int"},{"key":"21653_CR26","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.toxlet.2017.10.014","volume":"282","author":"C Ledda","year":"2018","unstructured":"Ledda C, Iavicoli I, Bracci M, Avola R, Senia P, Santarelli L, Pomara C, Rapisarda V (2018) Serum lipid, lipoprotein and apolipoprotein profiles in workers exposed to low arsenic levels: lipid profiles and occupational arsenic exposure. Toxicol Lett 282:49\u201356","journal-title":"Toxicol Lett"},{"key":"21653_CR27","doi-asserted-by":"publisher","first-page":"7580707","DOI":"10.1155\/2018\/7580707","volume":"2018","author":"L Li","year":"2018","unstructured":"Li L, Yang X (2018) The essential element manganese, oxidative stress, and metabolic diseases: links and interactions. Oxid Med Cell Longev 2018:7580707","journal-title":"Oxid Med Cell Longev"},{"key":"21653_CR28","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.neuro.2014.03.007","volume":"45","author":"Z Long","year":"2014","unstructured":"Long Z, Jiang YM, Li XR, Fadel W, Xu J, Yeh CL, Long LL, Luo HL, Harezlak J, Murdoch JB, Zheng W, Dydak U (2014) Vulnerability of welders to manganese exposure\u2013a neuroimaging study. Neurotoxicology 45:285\u2013292","journal-title":"Neurotoxicology"},{"key":"21653_CR29","doi-asserted-by":"publisher","first-page":"e005070","DOI":"10.1136\/bmjopen-2014-005070","volume":"4","author":"Y Lv","year":"2014","unstructured":"Lv Y, Zou Y, Liu J, Chen K, Huang D, Shen Y, Zhong Y, Liu Z, Jiang B, Li Q, Qing L, Zhang W, Chen L, Wang F, Xia B, Yang L, Yang X (2014) Rationale, design and baseline results of the Guangxi manganese-exposed workers healthy cohort (GXMEWHC) study. BMJ Open 4:e005070","journal-title":"BMJ Open"},{"key":"21653_CR30","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/s12020-013-0061-5","volume":"46","author":"SS Moon","year":"2014","unstructured":"Moon SS (2014) Additive effect of heavy metals on metabolic syndrome in the Korean population: the Korea National Health and Nutrition Examination Survey (KNHANES) 2009\u20132010. Endocrine 46:263\u2013271","journal-title":"Endocrine"},{"key":"21653_CR31","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1161\/CIRCRESAHA.115.306249","volume":"118","author":"BG Nordestgaard","year":"2016","unstructured":"Nordestgaard BG (2016) Triglyceride-rich lipoproteins and atherosclerotic cardiovascular disease: new insights from epidemiology, genetics, and biology. Circ Res 118:547\u2013563","journal-title":"Circ Res"},{"key":"21653_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jtemb.2018.05.018","volume":"50","author":"SY Ou","year":"2018","unstructured":"Ou SY, Luo HL, Mailman RB, Li ZC, Zhang YW, Cai M, Huang XW, Li SJ, Jiang YM (2018) Effect of manganese on neural endocrine hormones in serum of welders and smelters. J Trace Elem Med Biol 50:1\u20137","journal-title":"J Trace Elem Med Biol"},{"key":"21653_CR33","doi-asserted-by":"crossref","unstructured":"Park H, Kim K (2019) Comparisons among machine learning models for the prediction of hypercholestrolemia associated with exposure to lead, mercury, and cadmium. Int J Environ Res Public Health 16","DOI":"10.3390\/ijerph16152666"},{"key":"21653_CR34","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1007\/s10653-015-9758-0","volume":"38","author":"I Rotter","year":"2016","unstructured":"Rotter I, Kosik-Bogacka DI, Dolegowska B, Safranow K, Kuczynska M, Laszczynska M (2016) Analysis of the relationship between the blood concentration of several metals, macro- and micronutrients and endocrine disorders associated with male aging. Environ Geochem Health 38:749\u2013761","journal-title":"Environ Geochem Health"},{"key":"21653_CR35","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1021\/es0101227","volume":"36","author":"E Silva","year":"2002","unstructured":"Silva E, Rajapakse N, Kortenkamp A (2002) Something from \u201cnothing\u201d\u2013eight weak estrogenic chemicals combined at concentrations below NOECs produce significant mixture effects. Environ Sci Technol 36:1751\u20131756","journal-title":"Environ Sci Technol"},{"key":"21653_CR36","first-page":"550","volume":"79","author":"S Songchitsomboon","year":"1996","unstructured":"Songchitsomboon S, Komindr S (1996) Serum zinc and copper in healthy adults living in Bangkok and surrounding districts. J Med Assoc Thai 79:550\u2013557","journal-title":"J Med Assoc Thai"},{"key":"21653_CR37","doi-asserted-by":"publisher","first-page":"109538","DOI":"10.1016\/j.envres.2020.109538","volume":"186","author":"A Stojsavljevic","year":"2020","unstructured":"Stojsavljevic A, Rovcanin B, Jagodic J, Radojkovic DD, Paunovic I, Gavrovic-Jankulovic M, Manojlovic D (2020) Significance of arsenic and lead in Hashimoto\u2019s thyroiditis demonstrated on thyroid tissue, blood, and urine samples. Environ Res 186:109538","journal-title":"Environ Res"},{"key":"21653_CR38","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.atherosclerosis.2011.03.027","volume":"217","author":"S Stranges","year":"2011","unstructured":"Stranges S, Galletti F, Farinaro E, D\u2019Elia L, Russo O, Iacone R, Capasso C, Carginale V, De Luca V, Della Valle E, Cappuccio FP, Strazzullo P (2011) Associations of selenium status with cardiometabolic risk factors: an 8-year follow-up analysis of the Olivetti Heart study. Atherosclerosis 217:274\u2013278","journal-title":"Atherosclerosis"},{"key":"21653_CR39","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/S0021-9150(03)00145-X","volume":"169","author":"PA Svensson","year":"2003","unstructured":"Svensson PA, Englund MC, Markstrom E, Ohlsson BG, Jernas M, Billig H, Torgerson JS, Wiklund O, Carlsson LM, Carlsson B (2003) Copper induces the expression of cholesterogenic genes in human macrophages. Atherosclerosis 169:71\u201376","journal-title":"Atherosclerosis"},{"key":"21653_CR40","doi-asserted-by":"publisher","first-page":"8244","DOI":"10.1007\/s11356-016-6333-x","volume":"23","author":"X Wu","year":"2016","unstructured":"Wu X, Cobbina SJ, Mao G, Xu H, Zhang Z, Yang L (2016) A review of toxicity and mechanisms of individual and mixtures of heavy metals in the environment. Environ Sci Pollut Res Int 23:8244\u20138259","journal-title":"Environ Sci Pollut Res Int"},{"key":"21653_CR41","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.chemosphere.2018.10.060","volume":"215","author":"L Xiao","year":"2019","unstructured":"Xiao L, Zhou Y, Ma J, Cao L, Wang B, Zhu C, Yang S, Li W, Zhang Z, Wang D, Guo Y, Mu G, Yuan J, Chen W (2019) The cross-sectional and longitudinal associations of chromium with dyslipidemia: a prospective cohort study of urban adults in China. Chemosphere 215:362\u2013369","journal-title":"Chemosphere"},{"key":"21653_CR42","doi-asserted-by":"publisher","first-page":"116230","DOI":"10.1016\/j.envpol.2020.116230","volume":"269","author":"L Xiao","year":"2021","unstructured":"Xiao L, Zan G, Feng X, Bao Y, Huang S, Luo X, Xu X, Zhang Z, Yang X (2021) The associations of multiple metals mixture with accelerated DNA methylation aging. Environ Pollut 269:116230","journal-title":"Environ Pollut"},{"key":"21653_CR43","doi-asserted-by":"publisher","first-page":"126763","DOI":"10.1016\/j.chemosphere.2020.126763","volume":"254","author":"Y Xu","year":"2020","unstructured":"Xu Y, Wei Y, Long T, Wang R, Li Z, Yu C, Wu T, He M (2020) Association between urinary metals levels and metabolic phenotypes in overweight and obese individuals. Chemosphere 254:126763","journal-title":"Chemosphere"},{"key":"21653_CR44","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.jacl.2016.12.010","volume":"11","author":"CC Yang","year":"2017","unstructured":"Yang CC, Chuang CS, Lin CI, Wang CL, Huang YC, Chuang HY (2017) The association of the blood lead level and serum lipid concentrations may be modified by the genetic combination of the metallothionein 2A polymorphisms rs10636 GC and rs28366003 AA. J Clin Lipidol 11:234\u2013241","journal-title":"J Clin Lipidol"},{"key":"21653_CR45","doi-asserted-by":"crossref","unstructured":"Yang M, Liu Q, Huang T, Tan W, Qu L, Chen T, Pan H, Chen L, Liu J, Wong CW, Lu WW, Guan M (2020) Dysfunction of estrogen-related receptor alpha-dependent hepatic VLDL secretion contributes to sex disparity in NAFLD\/NASH development. Theranostics 10:10874\u201310891","DOI":"10.7150\/thno.47037"},{"key":"21653_CR46","doi-asserted-by":"publisher","first-page":"113950","DOI":"10.1016\/j.ijheh.2022.113950","volume":"242","author":"Y Yue","year":"2022","unstructured":"Yue Y, Nair N, Quinones S, Kordas K, Desai G (2022) Associations of total urinary arsenic with total cholesterol and high-density lipoprotein among 12\u201317-year-old participants from the 2009\u20132016 NHANES cycles: a cross-sectional study. Int J Hyg Environ Health 242:113950","journal-title":"Int J Hyg Environ Health"},{"key":"21653_CR47","doi-asserted-by":"publisher","first-page":"116791","DOI":"10.1016\/j.envpol.2021.116791","volume":"278","author":"G Zan","year":"2021","unstructured":"Zan G, Li L, Cheng H, Huang L, Huang S, Luo X, Xiao L, Liu C, Zhang H, Mo Z, Yang X (2021) Mediated relationships between multiple metals exposure and fasting blood glucose by reproductive hormones in Chinese men. Environ Pollut 278:116791","journal-title":"Environ Pollut"},{"key":"21653_CR48","doi-asserted-by":"publisher","first-page":"16951","DOI":"10.1007\/s11356-018-1816-6","volume":"25","author":"X Zang","year":"2018","unstructured":"Zang X, Huang H, Zhuang Z, Chen R, Xie Z, Xu C, Mo X (2018) The association between serum copper concentrations and cardiovascular disease risk factors in children and adolescents in NHANES. Environ Sci Pollut Res Int 25:16951\u201316958","journal-title":"Environ Sci Pollut Res Int"},{"key":"21653_CR49","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1159\/000452576","volume":"40","author":"Z Zhou","year":"2016","unstructured":"Zhou Z, Lu YH, Pi HF, Gao P, Li M, Zhang L, Pei LP, Mei X, Liu L, Zhao Q, Qin QZ, Chen Y, Jiang YM, Zhang ZH, Yu ZP (2016) Cadmium exposure is associated with the prevalence of dyslipidemia. Cell Physiol Biochem 40:633\u2013643","journal-title":"Cell Physiol Biochem"},{"key":"21653_CR50","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1186\/s12889-018-5880-0","volume":"18","author":"Y Zhou","year":"2018","unstructured":"Zhou Y, Ge X, Shen Y, Qin L, Zhong Y, Jiang C, Su C, Huang J, Lin S, Li D, Cheng H, Wei F, Ou S, Zou Y, Yang X (2018) Follow-up of the manganese-exposed workers healthy cohort (MEWHC) and biobank management from 2011 to 2017 in China. BMC Public Health 18:944","journal-title":"BMC Public Health"},{"key":"21653_CR51","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1007\/s12011-020-02270-0","volume":"199","author":"X Zhu","year":"2021","unstructured":"Zhu X, Fan Y, Sheng J, Gu L, Tao Q, Huang R, Liu K, Yang L, Chen G, Cao H, Li K, Tao F, Wang S (2021) Association between blood heavy metal concentrations and dyslipidemia in the elderly. Biol Trace Elem Res 199:1280\u20131290","journal-title":"Biol Trace Elem Res"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-022-21653-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11356-022-21653-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-022-21653-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T18:39:31Z","timestamp":1668191971000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11356-022-21653-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,6]]},"references-count":51,"journal-issue":{"issue":"56","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["21653"],"URL":"https:\/\/doi.org\/10.1007\/s11356-022-21653-5","relation":{},"ISSN":["0944-1344","1614-7499"],"issn-type":[{"value":"0944-1344","type":"print"},{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,6]]},"assertion":[{"value":"7 April 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Medical Ethics Committee of Guangxi Medical University (ID: 20200021) have approved all study procedures.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All participants have signed the informed consents for this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The manuscript is approved by all the authors for publication.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}}]}}