{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T07:15:01Z","timestamp":1793949301310,"version":"4.8.0"},"reference-count":83,"publisher":"Springer Science and Business Media LLC","issue":"59","license":[{"start":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T00:00:00Z","timestamp":1658275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T00:00:00Z","timestamp":1658275200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1007\/s11356-022-21945-w","type":"journal-article","created":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T04:02:42Z","timestamp":1658289762000},"page":"89712-89726","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Occurrence, ecological risk assessment and prioritization of pharmaceuticals and abuse drugs in estuarine waters along the S\u00e3o Paulo coast, Brazil"],"prefix":"10.1007","volume":"29","author":[{"given":"Vinicius","family":"Roveri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana Lopes","family":"Guimar\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walber","family":"Toma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2831-025X","authenticated-orcid":false,"given":"Alberto Teodorico","family":"Correia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,20]]},"reference":[{"key":"21945_CR1","unstructured":"Abrafarma. Brazilian Association of Pharmacy and Drugstore Chains. Abrafarma em n\u00fameros. 2017. Portal ABRAFARMA. Available in https:\/\/www.abrafarma.com.br\/sobre-1-c1mp6 Accessed: August 6th, 2021."},{"key":"21945_CR2","doi-asserted-by":"publisher","unstructured":"Adams E, Neves BB, Prola LDT, de Liz MV, Martins LRR, Ramsdorf WA, de Freitas AM (2020) Ecotoxicity and genotoxicity assessment of losartan after UV\/H2O2 and UVC\/photolysis treatments. Environ Sci Pollut Res. https:\/\/doi.org\/10.1007\/s11356-020-11420-9","DOI":"10.1007\/s11356-020-11420-9"},{"key":"21945_CR3","doi-asserted-by":"publisher","unstructured":"Arrais PSD, Fernandes MEP, da Pizzol TSD, Ramos LR, Mengue SS, Luiza VL, Bertoldi AD (2016) Prevalence of self-medication in Brazil and associated factors. Rev Saude Publica 50(Suppl 2). https:\/\/doi.org\/10.1590\/s1518-8787.2016050006117","DOI":"10.1590\/s1518-8787.2016050006117"},{"key":"21945_CR4","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.seppur.2017.06.019","volume":"186","author":"K Arola","year":"2017","unstructured":"Arola K, Hatakka H, M\u00e4ntt\u00e4ri M, Kallioinen M (2017) Novel process concept alternatives for improved removal of micropollutants in wastewater treatment. Sep Purif Technol 186:333\u2013341. https:\/\/doi.org\/10.1016\/j.seppur.2017.06.019","journal-title":"Sep Purif Technol"},{"key":"21945_CR5","doi-asserted-by":"publisher","unstructured":"Ashfaq M, Li Y, Rehman MSU, Zubair M, Mustafa G, Nazar MF, Sun Q (2019) Occurrence, spatial variation and risk assessment of pharmaceuticals and personal care products in urban wastewater, canal surface water, and their sediments: a case study of Lahore, Pakistan. Science of the Total Environment. doi:https:\/\/doi.org\/10.1016\/j.scitotenv.2019.06.285","DOI":"10.1016\/j.scitotenv.2019.06.285"},{"key":"21945_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2021.149002","volume":"797","author":"RW Becker","year":"2021","unstructured":"Becker RW, Alves Jachstet L, Dallegrave A, Ruiz-Padillo A, Zanella R, Sirtori C (2021) Multi-criteria decision-making techniques associated with (Q)SAR risk assessment for ranking surface water microcontaminants identified using LC-QTOF MS. Sci Total Environ 797:149002. https:\/\/doi.org\/10.1016\/j.scitotenv.2021.149002","journal-title":"Sci Total Environ"},{"issue":"2","key":"21945_CR7","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.toxlet.2007.10.012","volume":"176","author":"J-P Besse","year":"2008","unstructured":"Besse J-P, Garric J (2008) Human pharmaceuticals in surface waters. Toxicol Lett 176(2):104\u2013123. https:\/\/doi.org\/10.1016\/j.toxlet.2007.10.012","journal-title":"Toxicol Lett"},{"key":"21945_CR8","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.scitotenv.2017.08.2","volume":"612","author":"M Biel-Maeso","year":"2018","unstructured":"Biel-Maeso M, Baena-Nogueras RM, Corada-Fern\u00e1ndez C, Lara-Mart\u00edn PA (2018) Occurrence, distribution and environmental risk of pharmaceutically active compounds (PhACs) in coastal and ocean waters from the Gulf of Cadiz (SW Spain). Sci Total Environ 612:649\u2013659. https:\/\/doi.org\/10.1016\/j.scitotenv.2017.08.2","journal-title":"Sci Total Environ"},{"key":"21945_CR9","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1590\/S1519-69842006000500003","volume":"66","author":"JFV Biudes","year":"2006","unstructured":"Biudes JFV, Camargo AFM (2006) Changes in biomass, chemical composition and nutritive value of Spartina alterniflora due to organic pollution in the Itanha\u00e9m River Basin (SP, Brazil). Braz J Biol 66:781\u2013789. https:\/\/doi.org\/10.1590\/S1519-69842006000500003","journal-title":"Braz J Biol"},{"issue":"3","key":"21945_CR10","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.yrtph.2014.04.006","volume":"69","author":"C Bouissou-Schurtz","year":"2014","unstructured":"Bouissou-Schurtz C, Houeto P, Guerbet M, Bachelot M, Casellas C, Mauclaire A-C, Masset D (2014) Ecological risk assessment of the presence of pharmaceutical residues in a French national water survey. Regul Toxicol Pharmacol 69(3):296\u2013303. https:\/\/doi.org\/10.1016\/j.yrtph.2014.04.006","journal-title":"Regul Toxicol Pharmacol"},{"key":"21945_CR11","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.scitotenv.2016.04.125","volume":"563-564","author":"M Capolupo","year":"2016","unstructured":"Capolupo M, Valbonesi P, Kiwan A, Buratti S, Franzellitti S, Fabbri E (2016) Use of an integrated biomarker-based strategy to evaluate physiological stress responses induced by environmental concentrations of caffeine in the Mediterranean mussel Mytilus galloprovincialis. Sci Total Environ 563-564:538\u2013548. https:\/\/doi.org\/10.1016\/j.scitotenv.2016.04.125","journal-title":"Sci Total Environ"},{"key":"21945_CR12","doi-asserted-by":"publisher","first-page":"268","DOI":"10.4236\/ajcc.2017.62014","volume":"6","author":"IFA Cavalcanti","year":"2017","unstructured":"Cavalcanti IFA, Nunes LH, Marengo JA, Gomes JL, Silveira VP, Castellano MS (2017) Projections of precipitation changes in two vulnerable regions of S\u00e3o Paulo State, Brazil. Am J Clim Chang 6:268\u2013293. https:\/\/doi.org\/10.4236\/ajcc.2017.62014","journal-title":"Am J Clim Chang"},{"key":"21945_CR13","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1016\/j.scitotenv.2018.10.2","volume":"652","author":"M \u010celi\u0107","year":"2019","unstructured":"\u010celi\u0107 M, Gros M, Farr\u00e9 M, Barcel\u00f3 D, Petrovi\u0107 M (2019) Pharmaceuticals as chemical markers of wastewater contamination in the vulnerable area of the Ebro Delta (Spain). Sci Total Environ 652:952\u2013963. https:\/\/doi.org\/10.1016\/j.scitotenv.2018.10.2","journal-title":"Sci Total Environ"},{"key":"21945_CR14","unstructured":"Cetesb - Companhia Estadual de Tecnologia e Saneamento ambiental (2020) Relat\u00f3rio de qualidade das \u00e1guas costeiras no estado de S\u00e3o Paulo 2019. S\u00e9rie Relat\u00f3rios\/Ag\u00eancia Ambiental do Estado de S\u00e3o Paulo. ISSN 0103-4103"},{"issue":"6","key":"21945_CR15","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.1021\/es00006a009","volume":"29","author":"B Clark","year":"1995","unstructured":"Clark B, Henry GLH, Mackay D (1995) Fugacity analysis and model of organic chemical fate in a sewage treatment plant. Environ Sci Technol 29(6):1488\u20131494. https:\/\/doi.org\/10.1021\/es00006a009","journal-title":"Environ Sci Technol"},{"key":"21945_CR16","unstructured":"CMED - C\u00e2mara de Regula\u00e7\u00e3o do Mercado de Medicamentos (2019) Anu\u00e1rio Estat\u00edstico do Mercado Farmac\u00eautico. ANVISA, Bras\u00edlia, Brazil. Available in: http:\/\/portal.anvisa.gov.br\/"},{"key":"21945_CR17","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1016\/j.scitotenv.2018.05.0","volume":"637-638","author":"FS Cortez","year":"2018","unstructured":"Cortez FS, da Souza LS, Guimar\u00e3es LL, Almeida JE, Pusceddu FH, Maranho LA, Pereira CDS (2018) Ecotoxicological effects of losartan on the brown mussel Perna perna and its occurrence in seawater from Santos Bay (Brazil). Sci Total Environ 637-638:1363\u20131371. https:\/\/doi.org\/10.1016\/j.scitotenv.2018.05.0","journal-title":"Sci Total Environ"},{"key":"21945_CR18","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/j.scitotenv.2017.09.155","volume":"615","author":"R Dafouz","year":"2018","unstructured":"Dafouz R, C\u00e1ceres N, Rodr\u00edguez-Gil JL, Mastroianni N, L\u00f3pez de Alda M, Barcel\u00f3 D, Valc\u00e1rcel Y (2018) Does the presence of caffeine in the marine environment represent an environmental risk? A regional and global study. Sci Total Environ 615:632\u2013642. https:\/\/doi.org\/10.1016\/j.scitotenv.2017.09.155","journal-title":"Sci Total Environ"},{"key":"21945_CR19","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.jenvman.2015.06.037","volume":"160","author":"S Daouk","year":"2015","unstructured":"Daouk S, Ch\u00e8vre N, Vernaz N, Bonnabry P, Dayer P, Daali Y, Fleury-Souverain S (2015) Prioritization methodology for the monitoring of active pharmaceutical ingredients in hospital effluents. J Environ Manag 160:324\u2013332. https:\/\/doi.org\/10.1016\/j.jenvman.2015.06.037","journal-title":"J Environ Manag"},{"key":"21945_CR20","doi-asserted-by":"publisher","unstructured":"De Andrade Arag\u00e3o RB, Semensatto D, Calixto LA, Labuto G (2020) Pharmaceutical market, environmental public policies and water quality: the case of the S\u00e3o Paulo Metropolitan Region. Brazil Cad Sa\u00fade P\u00fablica 36. https:\/\/doi.org\/10.1590\/0102-311X00192319","DOI":"10.1590\/0102-311X00192319"},{"issue":"5","key":"21945_CR21","doi-asserted-by":"publisher","first-page":"e552","DOI":"10.1016\/s2214-109x(19)30157-3","volume":"7","author":"J Deen","year":"2019","unstructured":"Deen J, Von Seidlein L (2019) Paracetamol for dengue fever: no benefit and potential harm? Lancet Glob Health 7(5):e552\u2013e553. https:\/\/doi.org\/10.1016\/s2214-109x(19)30157-3","journal-title":"Lancet Glob Health"},{"issue":"3","key":"21945_CR22","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1002\/etc.3568","volume":"36","author":"V Di Nica","year":"2016","unstructured":"Di Nica V, Villa S, Finizio A (2016) Toxicity of individual pharmaceuticals and their mixtures to Aliivibrio fischeri: experimental results for single compounds and considerations of their mechanisms of action and potential acute effects on aquatic organisms. Environ Toxicol Chem 36(3):807\u2013814. https:\/\/doi.org\/10.1002\/etc.3568","journal-title":"Environ Toxicol Chem"},{"issue":"4","key":"21945_CR23","first-page":"308","volume":"10","author":"JC Dos Santos","year":"2012","unstructured":"Dos Santos JC, Faria Junior M, Restini CBA (2012) Potential drug interactions identified in prescriptions to hypertensive patients. Revista Brasileira de Clinica Medica S\u00e3o Paulo 10(4):308\u2013317","journal-title":"Revista Brasileira de Clinica Medica S\u00e3o Paulo"},{"key":"21945_CR24","doi-asserted-by":"publisher","unstructured":"Dufresne C, Arfib B, Ducros L, Duffa C, Giner F, Rey V (2020) Karst and urban flood-induced solid discharges in Mediterranean coastal rivers: the case study of Las River (SE France). J Hydrol 125194. https:\/\/doi.org\/10.1016\/j.jhydrol.2020.125194","DOI":"10.1016\/j.jhydrol.2020.125194"},{"key":"21945_CR25","unstructured":"ECB. (2003) Technical guidance document on risk assessment for existing substances, part II, pp. 108-110"},{"key":"#cr-split#-21945_CR26.1","unstructured":"EC (2015) European Commission. Commission Implementing Decision"},{"key":"#cr-split#-21945_CR26.2","unstructured":"(EU) 2015\/495 of 20 March 2015 establishing a watch list of substances for Union-wide monitoring in the field of water policy pursuant to Directive 2008\/105\/EC of the European Parliament and of the Council (notified under document C (2015) 1756). 3 p. 2015"},{"key":"21945_CR27","unstructured":"ECHA. (2008) Guidance on information requirements and chemical safety assessment. Chapter R.10: Characterisation of dose [concentration]-response for environment, pp7-29"},{"key":"21945_CR28","unstructured":"EMA - European Medicines Agency, Committee for Medicinal Products for Human use (CHMP) (2006) Guideline on the environmental risk assessment of medicinal products for human use. Doc. Ref.: EMEA\/CHMP\/SWP\/4447\/00 corr 1, London, UK"},{"issue":"3","key":"21945_CR29","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/j.scitotenv.2009.10.0","volume":"408","author":"C Fern\u00e1ndez","year":"2010","unstructured":"Fern\u00e1ndez C, Gonz\u00e1lez-Doncel M, Pro J, Carbonell G, Tarazona JV (2010) Occurrence of pharmaceutically active compounds in surface waters of the henares-jarama-tajo river system (madrid, spain) and a potential risk characterization. Sci Total Environ 408(3):543\u2013551. https:\/\/doi.org\/10.1016\/j.scitotenv.2009.10.0","journal-title":"Sci Total Environ"},{"key":"21945_CR30","doi-asserted-by":"publisher","unstructured":"Fern\u00e1ndez-Rubio J, Rodr\u00edguez-Gil JL, Postigo C, Mastroianni N, L\u00f3pez de Alda M, Barcel\u00f3 D, Valc\u00e1rcel Y (2019a) Psychoactive pharmaceuticals and illicit drugs in coastal waters of north-western Spain: environmental exposure and risk assessment. Chemosphere. https:\/\/doi.org\/10.1016\/j.chemosphere.2019.02","DOI":"10.1016\/j.chemosphere.2019.02"},{"issue":"1","key":"21945_CR31","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s10750-009-9932-4","volume":"636","author":"FC Ferreira","year":"2009","unstructured":"Ferreira FC, Petrere M (2009) The fish zonation of the Itanha\u00e9m River basin in the Atlantic Forest of southeast Brazil. Hydrobiologia 636(1):11\u201334. https:\/\/doi.org\/10.1007\/s10750-009-9932-4","journal-title":"Hydrobiologia"},{"key":"21945_CR32","doi-asserted-by":"publisher","unstructured":"Fern\u00e1ndez-Rubio J, Rodr\u00edguez-Gil JL, Postigo C, Mastroianni N, L\u00f3pez de Alda M, Barcel\u00f3 D, Valc\u00e1rcel Y (2019b) Psychoactive pharmaceuticals and illicit drugs in coastal waters of north-western Spain: environmental exposure and risk assessment. Chemosphere. https:\/\/doi.org\/10.1016\/j.chemosphere.2019.02","DOI":"10.1016\/j.chemosphere.2019.02"},{"key":"21945_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.marpolbul.2019.110545","volume":"149","author":"MK Fontes","year":"2019","unstructured":"Fontes MK, de Campos BG, Cortez FS, Pusceddu FH, Moreno BB, Maranho LA, Pereira CDS (2019) Seasonal monitoring of cocaine and benzoylecgonine in a subtropical coastal zone (Santos Bay, Brazil). Mar Pollut Bull 149:110545. https:\/\/doi.org\/10.1016\/j.marpolbul.2019.110545","journal-title":"Mar Pollut Bull"},{"key":"21945_CR34","doi-asserted-by":"publisher","unstructured":"Fontes MK, de Campos BG, Cortez FS, Pusceddu FH, Nobre CR, Moreno BB, Pereira CDS (2020) Mussels get higher: a study on the occurrence of cocaine and benzoylecgonine in seawater, sediment and mussels from a subtropical ecosystem (Santos Bay, Brazil). Sci Total Environ 143808. https:\/\/doi.org\/10.1016\/j.scitotenv.2020.143808","DOI":"10.1016\/j.scitotenv.2020.143808"},{"issue":"2","key":"21945_CR35","doi-asserted-by":"publisher","first-page":"61","DOI":"10.3390\/jox11020005","volume":"11","author":"LAA de Freitas","year":"2021","unstructured":"de Freitas LAA, Radis-Baptista G (2021) Pharmaceutical pollution and disposal of expired, unused, and unwanted medicines in the Brazilian context. J Xenobiotics 11(2):61\u201376. https:\/\/doi.org\/10.3390\/jox11020005","journal-title":"J Xenobiotics"},{"issue":"2","key":"21945_CR36","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1111\/jcpt.12502","volume":"42","author":"JT Hanlon","year":"2017","unstructured":"Hanlon JT, Perera S, Newman AB, Thorpe JM, Donohue JM, Simonsick EM (2017) Potential drug-drug and drug-disease interactions in well-functioning community-dwelling older adults. J Clin Pharm Ther 42(2):228\u2013233. https:\/\/doi.org\/10.1111\/jcpt.12502","journal-title":"J Clin Pharm Ther"},{"issue":"2","key":"21945_CR37","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.talanta.2005.09.037","volume":"69","author":"MD Hernando","year":"2006","unstructured":"Hernando MD, Mezcua M, Fernandez-Alba AR, Barcelo D (2006) Environmental risk assessment of pharmaceutical residues in wastewater effluents, surface waters and sediments. Talanta 69(2):334\u2013342. https:\/\/doi.org\/10.1016\/j.talanta.2005.09.037","journal-title":"Talanta"},{"key":"21945_CR38","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.aquatox.2012.12.016","volume":"132-133","author":"M Galus","year":"2013","unstructured":"Galus M, Jeyaranjaan J, Smith E, Li H, Metcalfe C, Wilson JY (2013) Chronic effects of exposure to a pharmaceutical mixture and municipal wastewater in zebrafish. Aquat Toxicol 132-133:212\u2013222. https:\/\/doi.org\/10.1016\/j.aquatox.2012.12.016","journal-title":"Aquat Toxicol"},{"key":"21945_CR39","doi-asserted-by":"publisher","unstructured":"Gonz\u00e1lez-Mari\u00f1o I, Baz-Lomba JA, Alygizakis NA, Andr\u00e9s-Costa MJ, Bade R, Barron LP, Bod\u00edk I (2019) Spatio-temporal assessment of illicit drug use at large scale: evidence from 7 years of international wastewater monitoring. Addiction. https:\/\/doi.org\/10.1111\/add.14767","DOI":"10.1111\/add.14767"},{"key":"21945_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2021.116494","volume":"273","author":"N Hamid","year":"2021","unstructured":"Hamid N, Junaid M, Wang Y, Pu S-Y, Jia P-P, Pei D-S (2021) Chronic exposure to PPCPs mixture at environmentally relevant concentrations (ERCs) altered carbohydrate and lipid metabolism through gut and liver toxicity in zebrafish. Environ Pollut 273:116494. https:\/\/doi.org\/10.1016\/j.envpol.2021.116494","journal-title":"Environ Pollut"},{"key":"21945_CR41","volume-title":"Estimativa da popula\u00e7\u00e3o brasileira","author":"Ibge \u2013 Instituto brasileiro de Geografia e Estat\u00edstica","year":"2019","unstructured":"Ibge \u2013 Instituto brasileiro de Geografia e Estat\u00edstica (2019) Estimativa da popula\u00e7\u00e3o brasileira. Brasil, Rio de Janeiro"},{"key":"21945_CR42","doi-asserted-by":"publisher","unstructured":"Korekar G, Kumar A, Ugale C (2019) Occurrence, fate, persistence, and remediation of caffeine: a review. Environ Sci Pollut Res. https:\/\/doi.org\/10.1007\/s11356-019-06998-8","DOI":"10.1007\/s11356-019-06998-8"},{"issue":"7","key":"21945_CR43","doi-asserted-by":"publisher","first-page":"6095","DOI":"10.1007\/s11356-017-9755-1","volume":"25","author":"S Lacorte","year":"2017","unstructured":"Lacorte S, Luis S, G\u00f3mez-Canela C, Sala-Comorera T, Courtier A, Roig B, Calas-Blanchard C (2017) Pharmaceuticals released from senior residences: occurrence and risk evaluation. Environ Sci Pollut Res 25(7):6095\u20136106. https:\/\/doi.org\/10.1007\/s11356-017-9755-1","journal-title":"Environ Sci Pollut Res"},{"issue":"3","key":"21945_CR44","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1002\/etc.1723","volume":"31","author":"JR Lawrence","year":"2012","unstructured":"Lawrence JR, Zhu B, Swerhone GDW, Roy J, Tumber V, Waiser MJ, Korber DR (2012) Molecular and microscopic assessment of the effects of caffeine, acetaminophen, diclofenac, and their mixtures on river biofilm communities. Environ Toxicol Chem 31(3):508\u2013517. https:\/\/doi.org\/10.1002\/etc.1723","journal-title":"Environ Toxicol Chem"},{"key":"21945_CR45","doi-asserted-by":"publisher","unstructured":"Maasz G, Mayer M, Zrinyi Z, Molnar E, Kuzma M, Fodor I, Tak\u00e1cs P (2019) Spatiotemporal variations of pharmacologically active compounds in surface waters of a summer holiday destination. Sci Total Environ. https:\/\/doi.org\/10.1016\/j.scitotenv.2019.04.286","DOI":"10.1016\/j.scitotenv.2019.04.286"},{"key":"21945_CR46","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.scitotenv.2016.07.210","volume":"572","author":"KC Machado","year":"2016","unstructured":"Machado KC, Grassi MT, Vidal C, Pescara IC, Jardim WF, Fernandes AN, Severo FJR (2016) A preliminary nationwide survey of the presence of emerging contaminants in drinking and source waters in Brazil. Sci Total Environ 572:138\u2013146. https:\/\/doi.org\/10.1016\/j.scitotenv.2016.07.210","journal-title":"Sci Total Environ"},{"key":"21945_CR47","doi-asserted-by":"crossref","unstructured":"Maranho LA, dos Santos DM, da Fonseca TG, Ortega ADSB, da Silva Sousa L, Pusceddu FH, Pereira CDS (2021) Occurrence and environmental fate of pharmaceuticals, personal care products and illicit drugs (PPCPIDs) in tropical ecosystems. Pharma Marine Coast Environ, 169-193","DOI":"10.1016\/B978-0-08-102971-8.00001-9"},{"key":"21945_CR48","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1016\/j.scitotenv.2016.02.0","volume":"551-552","author":"B Mathon","year":"2016","unstructured":"Mathon B, Choubert J-M, Miege C, Coquery M (2016) A review of the photodegradability and transformation products of 13 pharmaceuticals and pesticides relevant to sewage polishing treatment. Sci Total Environ 551-552:712\u2013724. https:\/\/doi.org\/10.1016\/j.scitotenv.2016.02.0","journal-title":"Sci Total Environ"},{"key":"21945_CR49","doi-asserted-by":"publisher","unstructured":"McNally RJ, Morselli F, Farukh B, Chowienczyk PJ, Faconti L (2019) A review of the prescribing trend of thiazide-type and thiazide like diuretics in hypertension: a UK perspective. Br J Clin Pharmacol. https:\/\/doi.org\/10.1111\/bcp.14109","DOI":"10.1111\/bcp.14109"},{"key":"21945_CR50","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2021.1497","volume":"803","author":"FV Mello","year":"2022","unstructured":"Mello FV, Cunha SC, Foga\u00e7a FHS, Alonso MB, Torres JPM, Fernandes JO (2022) Occurrence of pharmaceuticals in seafood from two Brazilian coastal areas: implication for human risk assessment. Sci Total Environ 803:149744. https:\/\/doi.org\/10.1016\/j.scitotenv.2021.1497","journal-title":"Sci Total Environ"},{"issue":"2","key":"21945_CR51","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1002\/ieam.1248","volume":"8","author":"CT Moermond","year":"2012","unstructured":"Moermond CT, Janssen MP, de Knecht JA, Montforts MH, Peijnenburg WJ, Zweers PG, Sijm DT (2012) PBT assessment using the revised annex XIII of REACH: a comparison with other regulatory frameworks. Integr Environ Assess Manag 8(2):359\u2013371. https:\/\/doi.org\/10.1002\/ieam.1248","journal-title":"Integr Environ Assess Manag"},{"key":"21945_CR52","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.ecolind.2018.12.052","volume":"101","author":"LB Moreira","year":"2019","unstructured":"Moreira LB, Leite PRBD, de Dias ML, de Martins CC, de Abessa DMS (2019) Sediment quality assessment as potential tool for the management of tropical estuarine protected areas in SW Atlantic, Brazil. Ecol Indic 101:238\u2013248. https:\/\/doi.org\/10.1016\/j.ecolind.2018.12.052","journal-title":"Ecol Indic"},{"issue":"4","key":"21945_CR53","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1590\/s1679-87592017128806504","volume":"65","author":"LB Moreira","year":"2017","unstructured":"Moreira LB, Vicente TM, Taniguchi S, Hortellani MA, Sarkis JES, B\u00edcego MC, de Abessa DMS (2017) Assessing legacy contaminants in sediments from marine protected areas of the central coast of S\u00e3o Paulo (Brazil). Braz J Oceanogr 65(4):549\u2013563. https:\/\/doi.org\/10.1590\/s1679-87592017128806504","journal-title":"Braz J Oceanogr"},{"issue":"5","key":"21945_CR54","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1039\/d0ay02098b","volume":"13","author":"D O\u2019Flynn","year":"2021","unstructured":"O\u2019Flynn D, Lawler J, Yusuf A, Parle-McDermott A, Harold D, Mc Cloughlin T, White B (2021) A review of pharmaceutical occurrence and pathways in the aquatic environment in the context of a changing climate and the COVID-19 pandemic. Anal Methods 13(5):575\u2013594. https:\/\/doi.org\/10.1039\/d0ay02098b","journal-title":"Anal Methods"},{"issue":"15","key":"21945_CR55","doi-asserted-by":"publisher","first-page":"11574","DOI":"10.1007\/s11356-015-4329-6","volume":"22","author":"B Nunes","year":"2015","unstructured":"Nunes B, Verde MF, Soares AMVM (2015) Biochemical effects of the pharmaceutical drug paracetamol on Anguilla anguilla. Environ Sci Pollut Res 22(15):11574\u201311584. https:\/\/doi.org\/10.1007\/s11356-015-4329-6","journal-title":"Environ Sci Pollut Res"},{"key":"21945_CR56","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.scitotenv.2016.01.051","volume":"548-549","author":"CDS Pereira","year":"2016","unstructured":"Pereira CDS, Maranho LA, Cortez FS, Pusceddu FH, Santos AR, Ribeiro DA, Cesar A, Guimar\u00e3es LL (2016) Occurrence of pharmaceuticals and cocaine in a Brazilian coastal zone. Sci Total Environ 548-549:148\u2013154. https:\/\/doi.org\/10.1016\/j.scitotenv.2016.01.051","journal-title":"Sci Total Environ"},{"issue":"31","key":"21945_CR57","doi-asserted-by":"publisher","first-page":"24061","DOI":"10.1007\/s11356-017-0097-9","volume":"24","author":"AL Pereira","year":"2017","unstructured":"Pereira AL, de Vasconcelos Barros RT, Pereira SR (2017) Pharmacy pollution and household waste medicine (HWM): how reverse logistics is environmentally important to Brazil. Environ Sci Pollut Res 24(31):24061\u201324075. https:\/\/doi.org\/10.1007\/s11356-017-0097-9","journal-title":"Environ Sci Pollut Res"},{"key":"21945_CR58","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.chemosphere.2015.12.035","volume":"146","author":"A Pires","year":"2016","unstructured":"Pires A, Almeida \u00c2, Correia J, Calisto V, Schneider RJ, Esteves VI, Freitas R (2016) Long-term exposure to caffeine and carbamazepine: impacts on the regenerative capacity of the polychaete Diopatra neapolitana. Chemosphere 146:565\u2013573. https:\/\/doi.org\/10.1016\/j.chemosphere.2015.12.035","journal-title":"Chemosphere"},{"key":"21945_CR59","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2021.118329","volume":"292","author":"FH Pusceddu","year":"2022","unstructured":"Pusceddu FH, Guimar\u00e3es MM, Lopes LO, Souza LS, Cortez FS, Pereira CDS, Cesar A (2022) Biological effects of the antihypertensive losartan under different ocean acidification scenarios. Environ Pollut 292:118329","journal-title":"Environ Pollut"},{"key":"21945_CR60","doi-asserted-by":"publisher","unstructured":"Quadra GR, Parana\u00edba JR, Vilas-Boas J, Roland F, Amado AM, Barros N, Cardoso SJ (2019) A global trend of caffeine consumption over time and related-environmental impacts. Environ Pollut 113343. https:\/\/doi.org\/10.1016\/j.envpol.2019.113343","DOI":"10.1016\/j.envpol.2019.113343"},{"issue":"3","key":"21945_CR61","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1016\/j.etap.2014.04.005","volume":"37","author":"AS Ramos","year":"2014","unstructured":"Ramos AS, Correia AT, Antunes SC, Gon\u00e7alves F, Nunes B (2014) Effect of acetaminophen exposure in Oncorhynchus mykiss gills and liver: detoxification mechanisms, oxidative defence system and peroxidative damage. Environ Toxicol Pharmacol 37(3):1221\u20131228. https:\/\/doi.org\/10.1016\/j.etap.2014.04.005","journal-title":"Environ Toxicol Pharmacol"},{"key":"21945_CR62","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2021.103727","volume":"87","author":"R Reque","year":"2021","unstructured":"Reque R, Carneiro RD, Yamamoto FY, Ramsdorf WA, Martins LR, Guiloski IC, de Freitas AM (2021) Ecotoxicity of losartan potassium in aquatic organisms of different trophic levels. Environ Toxicol Pharmacol 87:103727. https:\/\/doi.org\/10.1016\/j.etap.2021.103727","journal-title":"Environ Toxicol Pharmacol"},{"key":"21945_CR63","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.scitotenv.2014.01.121","volume":"479-480","author":"J Robles-Molina","year":"2014","unstructured":"Robles-Molina J, Gilbert-L\u00f3pez B, Garc\u00eda-Reyes JF, Molina-D\u00edaz A (2014) Monitoring of selected priority and emerging contaminants in the Guadalquivir River and other related surface waters in the province of Ja\u00e9n, South East Spain. Sci Total Environ 479-480:247\u2013257. https:\/\/doi.org\/10.1016\/j.scitotenv.2014.01.121","journal-title":"Sci Total Environ"},{"issue":"19","key":"21945_CR64","doi-asserted-by":"publisher","first-page":"19387","DOI":"10.1007\/s11356-016-7138-7","volume":"23","author":"TS Ribeiro","year":"2016","unstructured":"Ribeiro TS, Carvalho DP, Guimar\u00e3es MT, Campina NN, Lobarinhas MR, Lopes ALJ, Braga ALF (2016) Prevalence of hypertension and its associated factors in contaminated areas of the Santos-S\u00e3o Vicente Estuarine region and Bertioga, Brazil: 2006-2009. Environ Sci Pollut Res 23(19):19387\u201319396. https:\/\/doi.org\/10.1007\/s11356-016-7138-7","journal-title":"Environ Sci Pollut Res"},{"issue":"1","key":"21945_CR65","first-page":"ISSN: 2317-1308","volume":"1","author":"V Roveri","year":"2012","unstructured":"Roveri V, Barrella V, Ramires M (2012) Instruments of Law 9985\/00: a discussion of its effectiveness in environmental management Mosaic Ecological Station Jur\u00e9ia \/ Itatins, from Law 12.406\/06. Law and Social. Science 1(1):ISSN: 2317-1308","journal-title":"Science"},{"key":"21945_CR66","doi-asserted-by":"publisher","unstructured":"Roveri V, Guimar\u00e3es LL, Toma, Correia AT (2020a) Occurrence and ecological risk assessment of pharmaceuticals and cocaine in a beach area of Guaruj\u00e1, S\u00e3o Paulo State, Brazil, under the influence of urban surface runoff. Environ Sci Pollut Res. https:\/\/doi.org\/10.1007\/s11356-020-10316-y","DOI":"10.1007\/s11356-020-10316-y"},{"key":"21945_CR67","doi-asserted-by":"publisher","unstructured":"Roveri V, Guimar\u00e3es LL, Correia AT (2020b) Spatial and temporal evaluation of the urban runoff water flowing into recreational areas of Guaruj\u00e1, S\u00e3o Paulo State, Brazil. Intl J River Basin Manag 1\u20130. https:\/\/doi.org\/10.1080\/15715124.2020.1776304","DOI":"10.1080\/15715124.2020.1776304"},{"key":"21945_CR68","doi-asserted-by":"publisher","unstructured":"Roveri V, Guimar\u00e3es LL, Toma W, Correia AT (2021) Occurrence and ecological risk assessment of pharmaceuticals and cocaine in the urban drainage channels of Santos beaches (S\u00e3o Paulo, Brazil): a neglected, but sensitive issue. Environ Sci Pollut Res. https:\/\/doi.org\/10.1007\/s11356-021-15249-8","DOI":"10.1007\/s11356-021-15249-8"},{"key":"21945_CR69","doi-asserted-by":"crossref","unstructured":"S\u00e3o Paulo (2008) State Decree No. 53.528.Decreto de cria\u00e7\u00e3o do Mosaico de \u00c1reas Marinhas Protegidas do Litoral Paulista. N\u00b0 53.528, de 8 de outubro de 2008. D.O.E.","DOI":"10.5327\/Z1519-874X2008000200004"},{"key":"21945_CR70","doi-asserted-by":"publisher","unstructured":"Scavone C, Brusco S, Bertini M, Sportiello L, Rafaniello C, Zoccoli A, Capuano A (2020) Current pharmacological treatments for COVID-19: what\u2019s next? Br J Pharmacol. https:\/\/doi.org\/10.1111\/bph.15072","DOI":"10.1111\/bph.15072"},{"key":"21945_CR71","doi-asserted-by":"publisher","unstructured":"Shihomatzu, H. M., 2015. Desenvolvimento e Valida\u00e7\u00e3o de Metodologia SPE-LC-MS\/MS para determina\u00e7\u00e3o de F\u00e1rmacos e Droga de Abuso nas \u00c1guas da Represa Guarapiranga, S\u00e3o Paulo\/SP, Brasil. IPEN\/USP. https:\/\/doi.org\/10.11606\/T.85.2015.tde-28042015-095207","DOI":"10.11606\/T.85.2015.tde-28042015-095207"},{"issue":"9","key":"21945_CR72","doi-asserted-by":"publisher","first-page":"759","DOI":"10.2165\/11538460-000000000-00000","volume":"27","author":"S-R Secoli","year":"2010","unstructured":"Secoli S-R, Figueras A, Lebr\u00e3o ML, de Lima FD, Santos JLF (2010) Risk of potential drug-drug interactions among Brazilian elderly. Drugs Aging 27(9):759\u2013770. https:\/\/doi.org\/10.2165\/11538460-000000000-00000","journal-title":"Drugs Aging"},{"key":"21945_CR73","unstructured":"SMA\/CPLA \u2013 Secretaria de Meio Ambiente do Estado de S\u00e3o Paulo\/Coordena\u00e7\u00e3o de Planejamento Ambiental (2018) Zona Costeira Paulista: Relat\u00f3rio de Qualidade Ambiental. Org. Organizadores N\u00e1dia Gilma Beserra de Lima e Tatiana Camolez Morales Ferreira. SMA\/CPLA, S\u00e3o Paulo. Brasil"},{"key":"21945_CR74","unstructured":"SMA\/CPLEA \u2013 Secretaria do Meio Ambiente do Estado de S\u00e3o Paulo\/Coordenadoria de Planejamento e Educa\u00e7\u00e3o Ambiental (2016) Zoneamento Ecol\u00f3gico - Econ\u00f4mico \u2013 Baixada Santista, S\u00e3o Paulo, Brasil, 55 p"},{"key":"21945_CR75","unstructured":"UNODC - United Nations Office on Drugs and Crime (2020) World drug report, 2020. Booklet 1. Executive summary. Available at: https:\/\/wdr.unodc.org\/wdr2020\/en\/exsum.html"},{"key":"21945_CR76","unstructured":"USEPA - United States Environmental Protection Agency (2007) Method 1694: pharmaceuticals and personal care products in water, soil sediment, and biosolids by HPLC\/MS\/MS. Washington"},{"key":"21945_CR77","unstructured":"USEPA - United States Environmental Protection Agency (2017a) Ecological Structure-Activity Relationship Model (ECOSAR) class program. MS-Windows version 2.0. https:\/\/www.epa.gov\/tsca732screening-tools\/ecological-structure-activity-relationships-ecosarcpredictive-model"},{"key":"21945_CR78","unstructured":"USEPA - United States Environmental Protection Agency (2017b) Estimation Program Interface Suite (EPI Suite\u2122). Class program. MS-Windows version 4.11. https:\/\/www.epa.gov\/tsca-screening-tools\/download-epi-suitetm-estimation-program-interface-v411"},{"key":"21945_CR79","unstructured":"USEPA - United States Environmental Protection Agency, 2019. ECOTOX user guide: Ecotoxicology Database system, version 4.0. http:\/\/www.epa.gov\/ecotox\/."},{"key":"21945_CR80","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.scitotenv.2012.08.036","volume":"440","author":"P Vazquez-Roig","year":"2012","unstructured":"Vazquez-Roig P, Andreu V, Blasco C, Pic\u00f3 Y (2012) Risk assessment on the presence of pharmaceuticals in sediments, soils and waters of the Pego\u2013Oliva Marshlands (Valencia, eastern Spain). Sci Total Environ 440:24\u201332. https:\/\/doi.org\/10.1016\/j.scitotenv.2012.08.036","journal-title":"Sci Total Environ"},{"key":"21945_CR81","first-page":"49","volume":"1","author":"NS Yamamoto","year":"2012","unstructured":"Yamamoto NS, Dias C, Pereira S, Cortez FS, Pusceddu H, Santos AR, Guimaraes LL (2012) Avalia\u00e7\u00e3o dos efeitos biol\u00f3gicos do farmaco Losartan em microcrustaceos Daphnia similis e Ceriodaphnia dubia (Crustacea, Cladocera). Unisanta Bioscience 1:49\u201353","journal-title":"Unisanta Bioscience"},{"key":"21945_CR82","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.envint.2019.04.034","volume":"128","author":"SB Zhou","year":"2019","unstructured":"Zhou SB, Paolo CD, Wu XD, Shao Y, Seiler TB, Hollert H (2019) Optimization of screening-level risk assessment and priority selection of emerging pollutants \u2013 the case of pharmaceuticals in European surface waters. Environ Int 128:1\u201310","journal-title":"Environ Int"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-022-21945-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11356-022-21945-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-022-21945-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T08:54:46Z","timestamp":1744188886000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11356-022-21945-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,20]]},"references-count":83,"journal-issue":{"issue":"59","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["21945"],"URL":"https:\/\/doi.org\/10.1007\/s11356-022-21945-w","relation":{},"ISSN":["0944-1344","1614-7499"],"issn-type":[{"value":"0944-1344","type":"print"},{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,20]]},"assertion":[{"value":"14 January 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 July 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}