{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T16:34:20Z","timestamp":1785515660965,"version":"3.56.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T00:00:00Z","timestamp":1662768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T00:00:00Z","timestamp":1662768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100005001","name":"Ahvaz Jundishapur University of Medical Sciences","doi-asserted-by":"publisher","award":["TRC-9908"],"award-info":[{"award-number":["TRC-9908"]}],"id":[{"id":"10.13039\/501100005001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"DOI":"10.1007\/s11356-022-22941-w","type":"journal-article","created":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T09:02:43Z","timestamp":1662800563000},"page":"10880-10889","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Betaine protects against sodium arsenite-induced diabetes and hepatotoxicity in mice"],"prefix":"10.1007","volume":"30","author":[{"given":"Parian Pourmoafi","family":"Esfahani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoud","family":"Mahdavinia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Layasadat","family":"Khorsandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsen","family":"Rezaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hojatolla","family":"Nikravesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9518-1286","authenticated-orcid":false,"given":"Mohammad Javad","family":"Khodayar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,10]]},"reference":[{"key":"22941_CR1","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1007\/s11095-010-0080-3","volume":"27","author":"DR Abernethy","year":"2010","unstructured":"Abernethy DR, DeStefano AJ, Cecil TL et al (2010) Metal impurities in food and drugs. Pharm Res 27:750\u2013755. https:\/\/doi.org\/10.1007\/s11095-010-0080-3","journal-title":"Pharm Res"},{"key":"22941_CR2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-0020-3","author":"M Alaoui-Jamali","year":"2010","unstructured":"Alaoui-Jamali M (2010) Alternative and complementary therapies for cancer: integrative approaches and discovery of conventional drugs. Springer, New York, NY. https:\/\/doi.org\/10.1007\/978-1-4419-0020-3","journal-title":"Springer, New York, NY"},{"key":"22941_CR3","doi-asserted-by":"publisher","first-page":"661","DOI":"10.22270\/jddt.v9i3.2677","volume":"9","author":"M Baskar","year":"2019","unstructured":"Baskar M, Kiranmathyi B, Sivaraj C, Saraswathi KAP (2019) Journal of drug delivery and therapeutics. J Drug Deliv Ther 9:661\u2013668. https:\/\/doi.org\/10.22270\/jddt.v9i3.2677","journal-title":"J Drug Deliv Ther"},{"issue":"6 Pt 2","key":"22941_CR4","doi-asserted-by":"publisher","first-page":"F983","DOI":"10.1152\/ajprenal.1995.268.6.F983","volume":"268","author":"B Burg","year":"1995","unstructured":"Burg B (1995) Basis of osmotic regulation. Am J Physiol 268(6 Pt 2):F983\u2013F996. https:\/\/doi.org\/10.1152\/ajprenal.1995.268.6.F983","journal-title":"Am J Physiol"},{"key":"22941_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-020-78935-6","volume":"10","author":"Q Chen","year":"2020","unstructured":"Chen Q, Wang Y, Jiao F et al (2020) Betaine inhibits Toll-like receptor 4 responses and restores intestinal microbiota in acute liver failure mice. Sci Rep 10:1\u201314. https:\/\/doi.org\/10.1038\/s41598-020-78935-6","journal-title":"Sci Rep"},{"key":"22941_CR6","doi-asserted-by":"publisher","first-page":"2787","DOI":"10.1158\/1055-9965.EPI-07-0683","volume":"16","author":"E Cho","year":"2007","unstructured":"Cho E, Holmes M, Hankinson SE, Willett WC (2007) Nutrients involved in one-carbon metabolism and risk of breast cancer among premenopausal women. Cancer Epidemiol Biomarkers Prev 16:2787\u20132790. https:\/\/doi.org\/10.1158\/1055-9965.EPI-07-0683","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"22941_CR7","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/S0308-8146(03)00063-3","volume":"83","author":"FJ De Zwart","year":"2003","unstructured":"De Zwart FJ, Slow S, Payne RJ et al (2003) Glycine betaine and glycine betaine analogues in common foods. Food Chem 83:197\u2013204. https:\/\/doi.org\/10.1016\/S0308-8146(03)00063-3","journal-title":"Food Chem"},{"key":"22941_CR8","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1093\/toxsci\/kfv089","volume":"146","author":"SP Divya","year":"2015","unstructured":"Divya SP, Pratheeshkumar P, Son YO et al (2015) Adipocytes and myotubes via oxidative stress-regulated mitochondrial sirt3-FOXO3a signaling pathway. Toxicol Sci 146:290\u2013300. https:\/\/doi.org\/10.1093\/toxsci\/kfv089","journal-title":"Toxicol Sci"},{"key":"22941_CR9","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1007\/s11033-019-05217-4","volume":"47","author":"MA Dkhil","year":"2020","unstructured":"Dkhil MA, Abdel Moneim AE, Bauomy AA et al (2020) Chlorogenic acid prevents hepatotoxicity in arsenic-treated mice: role of oxidative stress and apoptosis. Mol Biol Rep 47:1161\u20131171. https:\/\/doi.org\/10.1007\/s11033-019-05217-4","journal-title":"Mol Biol Rep"},{"key":"22941_CR10","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.fct.2018.05.032","volume":"118","author":"S Dutta","year":"2018","unstructured":"Dutta S, Saha S, Mahalanobish S et al (2018) Melatonin attenuates arsenic induced nephropathy via the regulation of oxidative stress and inflammatory signaling cascades in mice. Food Chem Toxicol 118:303\u2013316. https:\/\/doi.org\/10.1016\/j.fct.2018.05.032","journal-title":"Food Chem Toxicol"},{"key":"22941_CR11","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.cj.2017.04.003","volume":"5","author":"Z Emami Bistgani","year":"2017","unstructured":"Emami Bistgani Z, Siadat SA, Bakhshandeh A et al (2017) Interactive effects of drought stress and chitosan application on physiological characteristics and essential oil yield of Thymus daenensis Celak. Crop J 5:407\u2013415. https:\/\/doi.org\/10.1016\/j.cj.2017.04.003","journal-title":"Crop J"},{"key":"22941_CR12","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/s00726-004-0105-5","volume":"27","author":"F Erman","year":"2004","unstructured":"Erman F, Balkan J, \u00c7evikba\u015f U et al (2004) Betaine or taurine administration prevents fibrosis and lipid peroxidation induced by rat liver by ethanol plus carbon tetrachloride intoxication. Amino Acids 27:199\u2013205. https:\/\/doi.org\/10.1007\/s00726-004-0105-5","journal-title":"Amino Acids"},{"key":"22941_CR13","doi-asserted-by":"publisher","first-page":"582","DOI":"10.4103\/0378-6323.45099","volume":"74","author":"P Ghosh","year":"2008","unstructured":"Ghosh P, Roy C, Das N, Sengupta S (2008) Epidemiology and prevention of chronic arsenicosis: an Indian perspective. Indian J Dermatol Venereol Leprol 74:582\u2013593. https:\/\/doi.org\/10.4103\/0378-6323.45099","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"22941_CR14","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1016\/j.envpol.2018.01.008","volume":"235","author":"M Grau-Perez","year":"2018","unstructured":"Grau-Perez M, Navas-Acien A, Galan-Chilet I et al (2018) Arsenic exposure, diabetes-related genes and diabetes prevalence in a general population from Spain. Environ Pollut 235:948\u2013955. https:\/\/doi.org\/10.1016\/j.envpol.2018.01.008","journal-title":"Environ Pollut"},{"key":"22941_CR15","doi-asserted-by":"publisher","first-page":"62","DOI":"10.5681\/hpp.2011.006","volume":"1","author":"B Hajalilou","year":"2011","unstructured":"Hajalilou B, Mosaferi M, Khaleghi F et al (2011) Effects of abandoned arsenic mine on water resources pollution in north west of iran. Heal Promot Perspect 1:62\u201370. https:\/\/doi.org\/10.5681\/hpp.2011.006","journal-title":"Heal Promot Perspect"},{"key":"22941_CR16","doi-asserted-by":"publisher","first-page":"393","DOI":"10.4103\/0976-9668.116986","volume":"4","author":"P Hemalatha","year":"2013","unstructured":"Hemalatha P, Reddy AG, Reddy YR, Shivakumar P (2013) Evaluation of protective effect of N-acetyl cysteine on arsenic-induced hepatotoxicity. J Nat Sci Biol Med 4:393\u2013395. https:\/\/doi.org\/10.4103\/0976-9668.116986","journal-title":"J Nat Sci Biol Med"},{"key":"22941_CR17","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1016\/j.biopha.2018.04.154","volume":"103","author":"MJ Khodayar","year":"2018","unstructured":"Khodayar MJ, Kalantari H, Khorsandi L et al (2018) Betaine protects mice against acetaminophen hepatotoxicity possibly via mitochondrial complex II and glutathione availability. Biomed Pharmacother 103:1436\u20131445. https:\/\/doi.org\/10.1016\/j.biopha.2018.04.154","journal-title":"Biomed Pharmacother"},{"key":"22941_CR18","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1093\/oxfordjournals.aje.a117031","volume":"139","author":"MS Lai","year":"1994","unstructured":"Lai MS, Hsueh YM, Chen CJ et al (1994) Ingested inorganic arsenic and prevalence of diabetes mellitus. Am J Epidemiol 139:484\u2013492. https:\/\/doi.org\/10.1093\/oxfordjournals.aje.a117031","journal-title":"Am J Epidemiol"},{"key":"22941_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fphar.2020.594496","volume":"11","author":"C Li","year":"2020","unstructured":"Li C, Zhang S, Li L et al (2020) Ursodeoxycholic acid protects against arsenic induced hepatotoxicity by the Nrf2 signaling pathway. Front Pharmacol 11:1\u201317. https:\/\/doi.org\/10.3389\/fphar.2020.594496","journal-title":"Front Pharmacol"},{"key":"22941_CR20","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.2147\/DDDT.S247947","volume":"14","author":"Y Liu","year":"2020","unstructured":"Liu Y, Liang Y, Zheng B et al (2020) Protective effects of crocetin on arsenic trioxide-induced hepatic injury: involvement of suppression in oxidative stress and inflammation through activation of nrf2 signaling pathway in rats. Drug Des Devel Ther 14:1921\u20131931. https:\/\/doi.org\/10.2147\/DDDT.S247947","journal-title":"Drug Des Devel Ther"},{"key":"22941_CR21","doi-asserted-by":"publisher","first-page":"921581","DOI":"10.1155\/2014\/921581","volume":"2014","author":"N Mirza","year":"2014","unstructured":"Mirza N, Mahmood Q, Maroof Shah M et al (2014) Plants as useful vectors to reduce environmental toxic arsenic content. Sci World J 2014:921581. https:\/\/doi.org\/10.1155\/2014\/921581","journal-title":"Sci World J"},{"key":"22941_CR22","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1080\/13556210500123043","volume":"10","author":"ML Murillo-Fuentes","year":"2005","unstructured":"Murillo-Fuentes ML, Artillo R, Ubeda N et al (2005) Hepatic S-adenosylmethionine after maternal alcohol exposure on offspring rats. Addict Biol 10:139\u2013144. https:\/\/doi.org\/10.1080\/13556210500123043","journal-title":"Addict Biol"},{"key":"22941_CR23","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.toxlet.2017.11.032","volume":"284","author":"K Renu","year":"2018","unstructured":"Renu K, Madhyastha H, Madhyastha R et al (2018) Role of arsenic exposure in adipose tissue dysfunction and its possible implication in diabetes pathophysiology. Toxicol Lett 284:86\u201395. https:\/\/doi.org\/10.1016\/j.toxlet.2017.11.032","journal-title":"Toxicol Lett"},{"key":"22941_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/biom10091351","volume":"10","author":"NK Roy","year":"2020","unstructured":"Roy NK, Murphy A, Costa M (2020) Arsenic methyltransferase and methylation of inorganic arsenic. Biomolecules 10:1\u201313. https:\/\/doi.org\/10.3390\/biom10091351","journal-title":"Biomolecules"},{"key":"22941_CR25","doi-asserted-by":"publisher","first-page":"6791","DOI":"10.5897\/IJPS11.1300","volume":"6","author":"M Safiuddin","year":"2011","unstructured":"Safiuddin M, Shirazi SM, Yussof S (2011) Arsenic contamination of groundwater in Bangladesh: a review. Int J Phys Sci 6:6791\u20136800. https:\/\/doi.org\/10.5897\/IJPS11.1300","journal-title":"Int J Phys Sci"},{"key":"22941_CR26","doi-asserted-by":"publisher","first-page":"704","DOI":"10.22037\/ijpr.2019.1100669","volume":"18","author":"S Soltani","year":"2019","unstructured":"Soltani S, Khodayar MJ, Yaghooti H et al (2019) Evaluation of the protective effects of doxycycline on acetaminophen-induced hepatotoxicity in mice. Iran J Pharm Res 18:704\u2013712. https:\/\/doi.org\/10.22037\/ijpr.2019.1100669","journal-title":"Iran J Pharm Res"},{"key":"22941_CR27","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1155\/2015\/368087","volume":"2015","author":"TC Sung","year":"2015","unstructured":"Sung TC, Huang JW, Guo HR, Bin SuS (2015) Association between arsenic exposure and diabetes: a meta-analysis. Biomed Res Int 2015:17\u201322. https:\/\/doi.org\/10.1155\/2015\/368087","journal-title":"Biomed Res Int"},{"key":"22941_CR28","doi-asserted-by":"publisher","first-page":"3275","DOI":"10.1016\/s0021-9258(19)83617-7","volume":"260","author":"CE Thomas","year":"1985","unstructured":"Thomas CE, Morehouse LA, Aust SD (1985) Ferritin and superoxide-dependent lipid peroxidation. J Biol Chem 260:3275\u20133280. https:\/\/doi.org\/10.1016\/s0021-9258(19)83617-7","journal-title":"J Biol Chem"},{"key":"22941_CR29","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/S0378-4274(02)00085-1","volume":"133","author":"CH Tseng","year":"2002","unstructured":"Tseng CH, Tseng CP, Chiou HY et al (2002) Epidemiologic evidence of diabetogenic effect of arsenic. Toxicol Lett 133:69\u201376. https:\/\/doi.org\/10.1016\/S0378-4274(02)00085-1","journal-title":"Toxicol Lett"},{"key":"22941_CR30","doi-asserted-by":"publisher","first-page":"3593","DOI":"10.1099\/mic.0.2007\/006361-0","volume":"153","author":"S van der Veen","year":"2007","unstructured":"van der Veen S, Hain T, Wouters JA et al (2007) The heat-shock response of Listeria monocytogenes comprises genes involved in heat shock, cell division, cell wall synthesis, and the SOS response. Microbiology 153:3593\u20133607. https:\/\/doi.org\/10.1099\/mic.0.2007\/006361-0","journal-title":"Microbiology"},{"key":"22941_CR31","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1038\/sj.cr.7290305","volume":"15","author":"ZX Wang","year":"2005","unstructured":"Wang ZX, Jiang CS, Liu L et al (2005) The role of Akt on arsenic trioxide suppression of 3T3-L1 preadipocyte differentiation. Cell Res 15:379\u2013386. https:\/\/doi.org\/10.1038\/sj.cr.7290305","journal-title":"Cell Res"},{"key":"22941_CR32","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.biocontrol.2017.02.011","volume":"108","author":"X Zhang","year":"2017","unstructured":"Zhang X, Zhang G, Li P et al (2017) Mechanisms of glycine betaine enhancing oxidative stress tolerance and biocontrol efficacy of Pichia caribbica against blue mold on apples. Biol Control 108:55\u201363. https:\/\/doi.org\/10.1016\/j.biocontrol.2017.02.011","journal-title":"Biol Control"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-022-22941-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11356-022-22941-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-022-22941-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T05:23:36Z","timestamp":1675401816000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11356-022-22941-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,10]]},"references-count":32,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["22941"],"URL":"https:\/\/doi.org\/10.1007\/s11356-022-22941-w","relation":{},"ISSN":["1614-7499"],"issn-type":[{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,10]]},"assertion":[{"value":"10 March 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 September 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 September 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}