{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:42:08Z","timestamp":1790959328765,"version":"4.1.0"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T00:00:00Z","timestamp":1665705600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T00:00:00Z","timestamp":1665705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"DOI":"10.1007\/s11356-022-23509-4","type":"journal-article","created":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T07:03:38Z","timestamp":1665731018000},"page":"19466-19476","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Hematological indices as indicators of inflammation induced by exposure to pesticides"],"prefix":"10.1007","volume":"30","author":[{"given":"Miguel Alfonso","family":"Ru\u00edz-Arias","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irma Martha","family":"Medina-D\u00edaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael Yvette","family":"Bernal-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Manuel","family":"Agraz-Cibri\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyndia Azucena","family":"Gonz\u00e1lez-Arias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Briscia Socorro","family":"Barr\u00f3n-Vivanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Francisco","family":"Herrera-Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Alberto","family":"Verd\u00edn-Betancourt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Francisco","family":"Zambrano-Zaragoza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurora Elizabeth","family":"Rojas-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,10,14]]},"reference":[{"issue":"8","key":"23509_CR1","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1038\/ni.3772","volume":"18","author":"IS Afonina","year":"2017","unstructured":"Afonina IS, Zhong Z, Karin M et al (2017) Limiting inflammation-the negative regulation of NF-\u03baB and the NLRP3 inflammasome. Nat Immunol 18(8):861\u2013869. https:\/\/doi.org\/10.1038\/ni.3772","journal-title":"Nat Immunol"},{"key":"23509_CR2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.674325","volume":"12","author":"PM Andrew","year":"2021","unstructured":"Andrew PM, Lein PJ (2021) Neuroinflammation as a therapeutic target for mitigating the long-term consequences of acute organophosphate intoxication. Front Pharmacol 12:674325. https:\/\/doi.org\/10.3389\/fphar.2021.674325","journal-title":"Front Pharmacol"},{"issue":"7","key":"23509_CR3","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1016\/j.neuint.2012.09.003","volume":"61","author":"M Astiz","year":"2012","unstructured":"Astiz M, de Alaniz MJ, Marra CA (2012) The oxidative damage and inflammation caused by pesticides are reverted by lipoic acid in rat brain. Neurochem Int 61(7):1231\u20131241. https:\/\/doi.org\/10.1016\/j.neuint.2012.09.003","journal-title":"Neurochem Int"},{"issue":"1","key":"23509_CR4","doi-asserted-by":"publisher","first-page":"32","DOI":"10.26453\/otjhs.984345","volume":"7","author":"C Aydin","year":"2022","unstructured":"Aydin C, Alpsoy \u015e, Yildirim \u0130 (2022) Predictive values of inflammation indexes in predicting mortality in patients with COVID 19 hospitalized in general intensive care unit. T\u00fcrk Sa\u011fl\u0131k Bilimleri Dergisi 7(1):32\u201339. https:\/\/doi.org\/10.26453\/otjhs.984345","journal-title":"T\u00fcrk Sa\u011fl\u0131k Bilimleri Dergisi"},{"issue":"2","key":"23509_CR5","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.toxlet.2014.01.039","volume":"230","author":"MT Baltazar","year":"2014","unstructured":"Baltazar MT, Dinis-Oliveira RJ, de Lourdes BM et al (2014) Pesticides exposure as etiological factors of Parkinson\u2019s disease and other neurodegenerative diseases \u2013 a mechanistic approach. Toxicol Lett 230(2):85\u2013103. https:\/\/doi.org\/10.1016\/j.toxlet.2014.01.039","journal-title":"Toxicol Lett"},{"issue":"3","key":"23509_CR6","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.neuro.2012.02.002","volume":"33","author":"CN Banks","year":"2012","unstructured":"Banks CN, Lein PJ (2012) A review of experimental evidence linking neurotoxic organophosphorus compounds and inflammation. Neurotoxicology 33(3):575\u2013584. https:\/\/doi.org\/10.1016\/j.neuro.2012.02.002","journal-title":"Neurotoxicology"},{"issue":"1","key":"23509_CR7","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.neuro.2004.07.004","volume":"26","author":"BK Barlow","year":"2005","unstructured":"Barlow BK, Lee DW, Cory-Slechta DA et al (2005) Modulation of antioxidant defense systems by the environmental pesticide maneb in dopaminergic cells. Neurotoxicology 26(1):63\u201375. https:\/\/doi.org\/10.1016\/j.neuro.2004.07.004","journal-title":"Neurotoxicology"},{"key":"23509_CR8","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.fct.2018.01.035","volume":"113","author":"AB Benitez-Trinidad","year":"2018","unstructured":"Benitez-Trinidad AB, Medina-D\u00edaz IM, Bernal-Hern\u00e1ndez YY et al (2018) Relationship between LINE-1 methylation pattern and pesticide exposure in urban sprayers. Food Chem Toxicol 113:125\u2013133. https:\/\/doi.org\/10.1016\/j.fct.2018.01.035","journal-title":"Food Chem Toxicol"},{"issue":"2","key":"23509_CR9","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.pneurobio.2005.06.004","volume":"76","author":"ML Block","year":"2005","unstructured":"Block ML, Hong JS (2005) Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism. Prog Neurobiol 76(2):77\u201398. https:\/\/doi.org\/10.1016\/j.pneurobio.2005.06.004","journal-title":"Prog Neurobiol"},{"issue":"37","key":"23509_CR10","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000017199","volume":"98","author":"ZX Cao","year":"2019","unstructured":"Cao ZX, Song YQ, Bai WJ et al (2019) Neutrophil-lymphocyte ratio as an early predictor for patients with acute paraquat poisoning: a retrospective analysis. Medicine 98(37):e17199. https:\/\/doi.org\/10.1097\/MD.0000000000017199","journal-title":"Medicine"},{"key":"23509_CR11","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/B978-1-4377-0881-3.00027-9","volume-title":"Zakim and Boyer's Hepatology","author":"M Cave","year":"2012","unstructured":"Cave M, Falkner KC, McClain C (2012) Chapter 27 Occupational and environmental hepatotoxicity. In: Boyer TD, Manns MP, Sanyal AJ (eds) Zakim and Boyer\u2019s Hepatology. Elsevier Inc, China, pp 476\u2013492"},{"issue":"23","key":"23509_CR12","doi-asserted-by":"publisher","first-page":"29291","DOI":"10.1007\/s11356-020-09203-3","volume":"27","author":"LV Cestonaro","year":"2020","unstructured":"Cestonaro LV, Garcia SC, Nascimento S et al (2020) Biochemical, hematological and immunological parameters and relationship with occupational exposure to pesticides and metals. Environ Sci Pollut Res Int 27(23):29291\u201329302. https:\/\/doi.org\/10.1007\/s11356-020-09203-3","journal-title":"Environ Sci Pollut Res Int"},{"key":"23509_CR13","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.foodcont.2019.04.015","volume":"104","author":"Z Chen","year":"2019","unstructured":"Chen Z, Xu Y, Li N et al (2019) A national-scale cumulative exposure assessment of organophosphorus pesticides through dietary vegetable consumption in China. Food Control 104:34\u201341. https:\/\/doi.org\/10.1016\/j.foodcont.2019.04.015","journal-title":"Food Control"},{"key":"23509_CR14","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.2147\/CMAR.S235519","volume":"12","author":"L Chen","year":"2020","unstructured":"Chen L, Kong X, Wang Z et al (2020) Pretreatment systemic infammation response index in patients with breast cancer treated with neoadjuvant chemotherapy as a useful prognostic indicator. Cancer Manag Res 12:1543. https:\/\/doi.org\/10.2147\/CMAR.S235519","journal-title":"Cancer Manag Res"},{"issue":"7","key":"23509_CR15","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1097\/JOM.0b013e3181e66d25","volume":"52","author":"S Dayton","year":"2010","unstructured":"Dayton S, Sandler D, Blair A et al (2010) Pesticide use and myocardial infarction incidence among farm women in the agricultural health study. J Occup Environ Med 52(7):693\u2013697. https:\/\/doi.org\/10.1097\/JOM.0b013e3181e66d25","journal-title":"J Occup Environ Med"},{"issue":"2","key":"23509_CR16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054722","volume":"8","author":"A di Penta","year":"2013","unstructured":"di Penta A, Moreno B, Reix S et al (2013) Oxidative stress and proinflammatory cytokines contribute to demyelination and axonal damage in a cerebellar culture model of neuroinflammation. PLoS ONE 8(2):e54722. https:\/\/doi.org\/10.1371\/journal.pone.0054722","journal-title":"PLoS ONE"},{"issue":"1","key":"23509_CR17","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1042\/CS20020240","volume":"104","author":"JS Duffield","year":"2003","unstructured":"Duffield JS (2003) The inflammatory macrophage: a story of Jekyll and Hyde. Clin Sci 104(1):27\u201338","journal-title":"Clin Sci"},{"issue":"3","key":"23509_CR18","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.jemermed.2014.01.034","volume":"47","author":"ZD Dundar","year":"2014","unstructured":"Dundar ZD, Ergin M, Koylu R et al (2014) Neutrophil-lymphocyte ratio in patients with pesticide poisoning. J Emerg Med 47(3):286\u2013293. https:\/\/doi.org\/10.1016\/j.jemermed.2014.01.034","journal-title":"J Emerg Med"},{"issue":"4","key":"23509_CR19","doi-asserted-by":"publisher","first-page":"29","DOI":"10.21608\/EJFSAT.2018.5005.1022","volume":"18","author":"NM Elhosary","year":"2018","unstructured":"Elhosary NM, Abdelbar E (2018) RED CELL distribution width, neutrophil lymphocyte and platelet lymphocyte ratios as prognostic markers in acutely pesticides-poisoned patients. EJFSAT 18(4):29\u201340. https:\/\/doi.org\/10.21608\/EJFSAT.2018.5005.1022","journal-title":"EJFSAT"},{"issue":"6342","key":"23509_CR20","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1126\/science.aam7928","volume":"356","author":"SA Eming","year":"2017","unstructured":"Eming SA, Wynn TA, Martin P (2017) Inflammation and metabolism in tissue repair and regeneration. Science 356(6342):1026\u20131030. https:\/\/doi.org\/10.1126\/science.aam7928","journal-title":"Science"},{"issue":"4","key":"23509_CR21","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.envint.2010.02.010","volume":"36","author":"C Everett","year":"2010","unstructured":"Everett C, Matheson E (2010) Biomarkers of pesticide exposure and diabetes in the 1999\u20132004 national health and nutrition examination survey. Environ Int 36(4):398\u2013401. https:\/\/doi.org\/10.1016\/j.envint.2010.02.010","journal-title":"Environ Int"},{"issue":"23","key":"23509_CR22","doi-asserted-by":"publisher","first-page":"5725","DOI":"10.3390\/molecules25235725","volume":"25","author":"AG Fois","year":"2020","unstructured":"Fois AG, Paliogiannis P, Scano V et al (2020) The systemic inflammation index on admission predicts in-hospital mortality in COVID-19 patients. Molecules 25(23):5725. https:\/\/doi.org\/10.3390\/molecules25235725","journal-title":"Molecules"},{"key":"23509_CR23","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.3389\/fimmu.2017.01085","volume":"8","author":"T Fujii","year":"2017","unstructured":"Fujii T, Mashimo M, Moriwaki Y et al (2017) Expression and function of the cholinergic system in immune cells. Front Immunol 8:1085. https:\/\/doi.org\/10.3389\/fimmu.2017.01085","journal-title":"Front Immunol"},{"issue":"1","key":"23509_CR24","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1186\/s12974-018-1198-1","volume":"15","author":"B Gargouri","year":"2018","unstructured":"Gargouri B, Yousif NM, Bouchard M et al (2018) Inflammatory and cytotoxic effects of bifenthrin in primary microglia and organotypic hippocampal slice cultures. J Neuroinflammation 15(1):159. https:\/\/doi.org\/10.1186\/s12974-018-1198-1","journal-title":"J Neuroinflammation"},{"key":"23509_CR25","first-page":"159","volume":"29","author":"S G\u00f3mez-Arroyo","year":"2013","unstructured":"G\u00f3mez-Arroyo S, Mart\u00ednez-Valenzuela C, Carbajal-L\u00f3pez Y et al (2013) Riesgo genot\u00f3xico por la exposici\u00f3n ocupacional a plaguicidas en Am\u00e9rica Latina. Rev Int De Contam Ambient 29:159\u2013180","journal-title":"Rev Int De Contam Ambient"},{"issue":"2","key":"23509_CR26","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/s41577-019-0215-7","volume":"20","author":"T Gong","year":"2020","unstructured":"Gong T, Liu L, Jiang W et al (2020) DAMP-sensing receptors in sterile inflammation and inflammatory diseases. Nat Rev Immunol 20(2):95\u2013112. https:\/\/doi.org\/10.1038\/s41577-019-0215-7","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"23509_CR27","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1007\/s44197-021-00021-5","volume":"12","author":"DA Hamad","year":"2022","unstructured":"Hamad DA, Aly MM, Abdelhameid MA et al (2022) Combined blood indexes of systemic inflammation as a mirror to admission to intensive care unit in COVID-19 patients: a multicentric study. J Epidemiol Glob Health 12(1):64\u201373. https:\/\/doi.org\/10.1007\/s44197-021-00021-5","journal-title":"J Epidemiol Glob Health"},{"issue":"36","key":"23509_CR28","doi-asserted-by":"publisher","first-page":"50825","DOI":"10.1007\/s11356-021-14270-1","volume":"28","author":"JF Herrera-Moreno","year":"2021","unstructured":"Herrera-Moreno JF, Medina-D\u00edaz IM, Bernal-Hern\u00e1ndez YY et al (2021) Organophosphorus pesticide exposure biomarkers in a Mexican population. Environ Sci Pollut Res 28(36):50825\u201350834. https:\/\/doi.org\/10.1007\/s11356-021-14270-1","journal-title":"Environ Sci Pollut Res"},{"key":"23509_CR29","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1053\/j.gastro.2010.09.004","volume":"139","author":"GM Hirschfield","year":"2010","unstructured":"Hirschfield GM, Heathcote EJ, Gershwin ME (2010) Reviews in basic and clinical gastroenterology and hepatology. Gastroenterology 139:1481\u20131496. https:\/\/doi.org\/10.1053\/j.gastro.2010.09.004","journal-title":"Gastroenterology"},{"issue":"23","key":"23509_CR30","doi-asserted-by":"publisher","first-page":"6212","DOI":"10.1158\/1078-0432.CCR-14-0442","volume":"20","author":"B Hu","year":"2014","unstructured":"Hu B, Yang X-R, Xu Y et al (2014) Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma. Clin Cancer Res 20(23):6212\u20136222. https:\/\/doi.org\/10.1158\/1078-0432.CCR-14-0442","journal-title":"Clin Cancer Res"},{"key":"23509_CR31","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1128\/9781555819194.ch18","volume-title":"Myeloid Cells in Health and Disease: A Synthesis","author":"AJ Iqbal","year":"2017","unstructured":"Iqbal AJ, Fisher EA, Greaves DR (2017) Chapter 18 inflammation\u2014a critical appreciation of the role of myeloid cells. In: Gordon S (ed) Myeloid Cells in Health and Disease: A Synthesis. ASM Press, Washington, pp 325\u2013342"},{"issue":"8","key":"23509_CR32","first-page":"96","volume":"3","author":"A Jab\u0142o\u0144ska-Trypu\u0107","year":"2017","unstructured":"Jab\u0142o\u0144ska-Trypu\u0107 A (2017) Pesticides as inducers of oxidative stress. React Oxyg Species 3(8):96\u2013110","journal-title":"React Oxyg Species"},{"issue":"5","key":"23509_CR33","doi-asserted-by":"publisher","first-page":"384","DOI":"10.5762\/KAIS.2020.21.5.384","volume":"21","author":"JH Jeong","year":"2020","unstructured":"Jeong JH, Sun KH (2020) Role of neutrophil\/lymphocyte ratio as a predictor of mortality in organophosphate poisoning. J Korea Acad-Industr Coop Soc 21(5):384\u2013390. https:\/\/doi.org\/10.5762\/KAIS.2020.21.5.384","journal-title":"J Korea Acad-Industr Coop Soc"},{"issue":"8","key":"23509_CR34","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1007\/s11255-014-0730-1","volume":"46","author":"M Kanbay","year":"2014","unstructured":"Kanbay M, Solak Y, Unal HU et al (2014) Monocyte count\/HDL cholesterol ratio and cardiovascular events in patients with chronic kidney disease. Int Urol Nephrol 46(8):1619\u20131625","journal-title":"Int Urol Nephrol"},{"issue":"3","key":"23509_CR35","doi-asserted-by":"publisher","first-page":"1799","DOI":"10.1007\/s10072-021-05507-5","volume":"43","author":"SP Kara","year":"2022","unstructured":"Kara SP, Altunan B, Unal A (2022) Investigation of the peripheral inflammation (neutrophil\u2013lymphocyte ratio) in two neurodegenerative diseases of the central nervous system. Neurol Sci 43(3):1799\u20131807. https:\/\/doi.org\/10.1007\/s10072-021-05507-5","journal-title":"Neurol Sci"},{"issue":"1","key":"23509_CR36","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1093\/toxsci\/61.1.100","volume":"61","author":"ML Kirby","year":"2001","unstructured":"Kirby ML, Barlow RL, Bloomquist JR (2001) Neurotoxicity of the organochlorine insecticide heptachlor to murine striatal dopaminergic pathways. Toxicol Sci 61(1):100\u2013106. https:\/\/doi.org\/10.1093\/toxsci\/61.1.100","journal-title":"Toxicol Sci"},{"issue":"8","key":"23509_CR37","doi-asserted-by":"publisher","first-page":"865","DOI":"10.3390\/ijerph14080865","volume":"14","author":"M Koureas","year":"2017","unstructured":"Koureas M, Rachiotis G, Tsakalof A et al (2017) Increased frequency of rheumatoid arthritis and allergic rhinitis among pesticide sprayers and associations with pesticide use. Int J Environ Res Public Health 14(8):865. https:\/\/doi.org\/10.3390\/ijerph14080865","journal-title":"Int J Environ Res Public Health"},{"issue":"3","key":"23509_CR38","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1016\/j.cyto.2012.07.030","volume":"60","author":"D Koziorowski","year":"2012","unstructured":"Koziorowski D, Tomasiuk R, Szlufik S et al (2012) Inflammatory cytokines and NT-proCNP in Parkinson\u2019s disease patients. Cytokine 60(3):762\u2013766. https:\/\/doi.org\/10.1016\/j.cyto.2012.07.030","journal-title":"Cytokine"},{"issue":"9","key":"23509_CR39","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1289\/ehp.1307613","volume":"122","author":"J Kumar","year":"2014","unstructured":"Kumar J, Lind PM, Salihovic S et al (2014) Persistent organic pollutants and inflammatory markers in a cross-sectional study of elderly Swedish people: the PIVUS cohort. Environ Health Perspect 122(9):977\u2013983. https:\/\/doi.org\/10.1289\/ehp.1307613","journal-title":"Environ Health Perspect"},{"issue":"3","key":"23509_CR40","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/S0753-3322(99)80077-8","volume":"53","author":"DG Le Couteur","year":"1999","unstructured":"Le Couteur DG, McLean AJ, Taylor MC et al (1999) Pesticides and Parkinson\u2019s disease. Biomed Pharmacother 53(3):122\u2013130. https:\/\/doi.org\/10.1016\/S0753-3322(99)80077-8","journal-title":"Biomed Pharmacother"},{"issue":"6 Suppl","key":"23509_CR41","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.3945\/ajcn.110.001669","volume":"94","author":"J Legler","year":"2011","unstructured":"Legler J, Hamers T, van Eck van der Sluijs-van de Bor M, et al (2011) The OBELIX project: early life exposure to endocrine disruptors and obesity. Am J Clin Nutr 94(6 Suppl):1933\u20131938. https:\/\/doi.org\/10.3945\/ajcn.110.001669","journal-title":"Am J Clin Nutr"},{"issue":"3","key":"23509_CR42","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.taap.2011.03.026","volume":"253","author":"Y Li","year":"2011","unstructured":"Li Y, Lein PJ, Liu C et al (2011) Spatiotemporal pattern of neuronal injury induced by DFP in rats: a model for delayed neuronal cell death following acute OP intoxication. Toxicol Appl Pharmacol 253(3):261\u2013269. https:\/\/doi.org\/10.1016\/j.taap.2011.03.026","journal-title":"Toxicol Appl Pharmacol"},{"issue":"82","key":"23509_CR43","doi-asserted-by":"publisher","first-page":"35293","DOI":"10.18632\/oncotarget.24293","volume":"9","author":"C Li","year":"2018","unstructured":"Li C, Tian W, Zhao F et al (2018) Systemic immune-inflammation index, SII, for prognosis of elderly patients with newly diagnosed tumors. Oncotarget 9(82):35293. https:\/\/doi.org\/10.18632\/oncotarget.24293","journal-title":"Oncotarget"},{"key":"23509_CR44","doi-asserted-by":"publisher","unstructured":"Li H, Huang J, Pan W et al (2020) Systemic immune-inflammatory index predicts prognosis of patients with COVID-19: a retrospective study. Research Square 1\u201330. https:\/\/doi.org\/10.21203\/rs.3.rs-30701\/v1","DOI":"10.21203\/rs.3.rs-30701\/v1"},{"key":"23509_CR45","doi-asserted-by":"publisher","first-page":"4696156","DOI":"10.1155\/2021\/4696156","volume":"2021","author":"C Lionte","year":"2021","unstructured":"Lionte C, Bologa C, Sorodoc V et al (2021) Biomarkers of inflammation and inflammation-related indexes upon emergency department admission are predictive for the risk of intensive care unit hospitalization and mortality in acute poisoning: a 6-year prospective observational study. Dis Markers 2021:4696156. https:\/\/doi.org\/10.1155\/2021\/4696156","journal-title":"Dis Markers"},{"key":"23509_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.107391","volume":"93","author":"J Lu","year":"2021","unstructured":"Lu J, Wu W (2021) Cholinergic modulation of the immune system \u2013 a novel therapeutic target for myocardial inflammation. Int Immunopharmacol 93:107391. https:\/\/doi.org\/10.1016\/j.intimp.2021.107391","journal-title":"Int Immunopharmacol"},{"issue":"3","key":"23509_CR47","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.shaw.2013.07.004","volume":"4","author":"E Macfarlane","year":"2013","unstructured":"Macfarlane E, Carey R, Keegel T et al (2013) Dermal exposure associated with occupational end use of pesticides and the role of protective measures. Saf Health Work 4(3):136\u2013141. https:\/\/doi.org\/10.1016\/j.shaw.2013.07.004","journal-title":"Saf Health Work"},{"issue":"2","key":"23509_CR48","doi-asserted-by":"publisher","first-page":"138","DOI":"10.3109\/1354750X.2015.1118545","volume":"21","author":"FZ Madani","year":"2016","unstructured":"Madani FZ, Hafida M, Merzouk SA et al (2016) Hemostatic, inflammatory, and oxidative markers in pesticide user farmers. Biomarkers 21(2):138\u2013145. https:\/\/doi.org\/10.3109\/1354750X.2015.1118545","journal-title":"Biomarkers"},{"issue":"2","key":"23509_CR49","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.22228","volume":"32","author":"X Meng","year":"2018","unstructured":"Meng X, Chang Q, Liu Y et al (2018) Determinant roles of gender and age on SII, PLR, NLR, LMR and MLR and their reference intervals defining in Henan, China: a posteriori and big-data-based. J Clin Lab Anal 32(2):e22228. https:\/\/doi.org\/10.1002\/jcla.22228","journal-title":"J Clin Lab Anal"},{"issue":"12","key":"23509_CR50","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1097\/dcr.0000000000001484","volume":"62","author":"Y Miyamoto","year":"2019","unstructured":"Miyamoto Y, Hiyoshi Y, Daitoku N et al (2019) Naples prognostic score is a useful prognostic marker in patients with metastatic colorectal cancer. Dis Colon Rectum 62(12):1485\u20131493. https:\/\/doi.org\/10.1097\/dcr.0000000000001484","journal-title":"Dis Colon Rectum"},{"issue":"2","key":"23509_CR51","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.taap.2013.01.025","volume":"268","author":"S Mostafalou","year":"2013","unstructured":"Mostafalou S, Abdollahi M (2013) Pesticides and human chronic diseases: evidences, mechanisms, and perspectives. Toxicol Appl Pharmacol 268(2):157\u2013177. https:\/\/doi.org\/10.1016\/j.taap.2013.01.025","journal-title":"Toxicol Appl Pharmacol"},{"issue":"1","key":"23509_CR52","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1515\/biol-2021-0069","volume":"16","author":"Y Mu","year":"2021","unstructured":"Mu Y, Hu B, Gao N et al (2021) Prognostic value of the neutrophil-to-lymphocyte ratio in acute organophosphorus pesticide poisoning. Open Life Sci 16(1):703\u2013710. https:\/\/doi.org\/10.1515\/biol-2021-0069","journal-title":"Open Life Sci"},{"issue":"3","key":"23509_CR53","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2022.e09040","volume":"8","author":"F Nejatifar","year":"2022","unstructured":"Nejatifar F, Abdollahi M, Attarchi M et al (2022) Evaluation of hematological indices among insecticides factory workers. Heliyon 8(3):e09040. https:\/\/doi.org\/10.1016\/j.heliyon.2022.e09040","journal-title":"Heliyon"},{"key":"23509_CR54","doi-asserted-by":"publisher","unstructured":"Ortiz-L\u00f3pez D, Acosta-M\u00e9rida MA, Casimiro-P\u00e9rez JA et al\u00a0(2022) Valor del Ratio Neutr\u00f3filo-Linfocito, Ratio Plaqueta-Linfocito y Prote\u00edna C Reactiva del primer d\u00eda como predictores de complicaciones postoperatorias tras cirug\u00eda oncol\u00f3gica g\u00e1strica. Revista de Gastroenterolog\u00eda de M\u00e9xico 87(2):142\u2013148. https:\/\/doi.org\/10.1016\/j.rgmx.2020.10.003","DOI":"10.1016\/j.rgmx.2020.10.003"},{"issue":"1","key":"23509_CR55","doi-asserted-by":"publisher","first-page":"13147","DOI":"10.1038\/s41598-018-31599-9","volume":"8","author":"AD Petrescu","year":"2018","unstructured":"Petrescu AD, Grant S, Frampton G et al (2018) Gulf war illness-related chemicals increase CD11b\/c+ monocyte infiltration into the liver and aggravate hepatic cholestasis in a rodent model. Sci Rep 8(1):13147. https:\/\/doi.org\/10.1038\/s41598-018-31599-9","journal-title":"Sci Rep"},{"issue":"6","key":"23509_CR56","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.1590\/1413-81232018246.13142017","volume":"24","author":"C Piccoli","year":"2019","unstructured":"Piccoli C, Cremonese C, Koifman R et al (2019) Occupational exposure to pesticides and hematological alterations: a survey of farm residents in the South of Brazil. Cien Saude Colet 24(6):2325\u20132340. https:\/\/doi.org\/10.1590\/1413-81232018246.13142017","journal-title":"Cien Saude Colet"},{"key":"23509_CR57","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbi.2016.07.003","volume":"61","author":"EE Spangenberg","year":"2017","unstructured":"Spangenberg EE, Green KN (2017) Inflammation in Alzheimer\u2019s disease: lessons learned from microglia-depletion models. Brain Behav Immun 61:1\u201311. https:\/\/doi.org\/10.1016\/j.bbi.2016.07.003","journal-title":"Brain Behav Immun"},{"key":"23509_CR58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2022\/5563759","volume":"2022","author":"RO Sule","year":"2022","unstructured":"Sule RO, Condon L, Gomes AV (2022) A common feature of pesticides: oxidative stress\u2014the role of oxidative stress in pesticide-induced toxicity. Oxid Med Cell Longev 2022:1\u201331. https:\/\/doi.org\/10.1155\/2022\/5563759","journal-title":"Oxid Med Cell Longev"},{"issue":"7","key":"23509_CR59","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1021\/acs.chemrestox.9b00148","volume":"32","author":"V Vilas-Boas","year":"2019","unstructured":"Vilas-Boas V, Gijbels E, Cooreman A et al (2019) Industrial, biocide, and cosmetic chemical inducers of cholestasis. Chem Res Toxicol 32(7):1327\u20131334. https:\/\/doi.org\/10.1021\/acs.chemrestox.9b00148","journal-title":"Chem Res Toxicol"},{"issue":"20","key":"23509_CR60","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000015702","volume":"98","author":"WJ Wang","year":"2019","unstructured":"Wang WJ, Cao ZX, Feng SY et al (2019) Platelet-lymphocyte ratio is not a prognostic predictor for acute paraquat-intoxicated patients: a retrospective analysis. Medicine 98(20):e15702. https:\/\/doi.org\/10.1097\/MD.0000000000015702","journal-title":"Medicine"},{"key":"23509_CR61","unstructured":"WHO. The WHO recommended classification of pesticides by hazard and guidelines to classification, (2019) edition Available online: https:\/\/www.who.int\/publications\/i\/item\/9789240005662 (accessed on 30 March 2022)."},{"key":"23509_CR62","unstructured":"WHO. Obesity and overweight (2021) Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/obesity-and-overweight (accessed on 8 August 2022)."},{"key":"23509_CR63","unstructured":"WHO. Body mass index (BMI) (2022) available online: https:\/\/www.who.int\/data\/gho\/data\/themes\/topics\/topic-details\/GHO\/body-mass-index (accessed on 30 March 2022)."},{"issue":"34","key":"23509_CR64","doi-asserted-by":"publisher","first-page":"26444","DOI":"10.1007\/s11356-017-0064-5","volume":"24","author":"HL Wong","year":"2017","unstructured":"Wong HL, Garthwaite DG, Ramwell CT et al (2017) How does exposure to pesticides vary in space and time for residents living near to treated orchards? Environ Sci Pollut Res Int 24(34):26444\u201326461. https:\/\/doi.org\/10.1007\/s11356-017-0064-5","journal-title":"Environ Sci Pollut Res Int"},{"issue":"13","key":"23509_CR65","doi-asserted-by":"publisher","first-page":"7227","DOI":"10.3390\/ijms22137227","volume":"22","author":"LS Wong","year":"2021","unstructured":"Wong LS, Yen YT, Lee CH (2021) The implications of Pruritogens in the pathogenesis of atopic dermatitis. Int J Mol Sci 22(13):7227. https:\/\/doi.org\/10.3390\/ijms22137227","journal-title":"Int J Mol Sci"},{"issue":"6","key":"23509_CR66","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1002\/tox.22398","volume":"32","author":"R Zepeda-Arce","year":"2017","unstructured":"Zepeda-Arce R, Rojas-Garc\u00eda AE, Benitez-Trinidad A et al (2017) Oxidative stress and genetic damage among workers exposed primarily to organophosphate and pyrethroid pesticides. Environ Toxicol 32(6):1754\u20131764. https:\/\/doi.org\/10.1002\/tox.22398","journal-title":"Environ Toxicol"},{"issue":"1","key":"23509_CR67","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep36235","volume":"6","author":"DC Zhou","year":"2016","unstructured":"Zhou DC, Zhang H, Luo ZM et al (2016) Prognostic value of hematological parameters in patients with paraquat poisoning. Sci Rep 6(1):1\u20139. https:\/\/doi.org\/10.1038\/srep36235","journal-title":"Sci Rep"},{"issue":"18","key":"23509_CR68","doi-asserted-by":"publisher","first-page":"4134","DOI":"10.3390\/jcm10184134","volume":"10","author":"A Zinellu","year":"2021","unstructured":"Zinellu A, Collu C, Nasser M et al (2021) The aggregate index of systemic inflammation (AISI): a novel prognostic biomarker in idiopathic pulmonary fibrosis. J Clin Med 10(18):4134. https:\/\/doi.org\/10.3390\/jcm10184134","journal-title":"J Clin Med"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-022-23509-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11356-022-23509-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-022-23509-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T14:13:31Z","timestamp":1744208011000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11356-022-23509-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,14]]},"references-count":68,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["23509"],"URL":"https:\/\/doi.org\/10.1007\/s11356-022-23509-4","relation":{},"ISSN":["1614-7499"],"issn-type":[{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,14]]},"assertion":[{"value":"2 June 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 October 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Bioethics Commission of the State of Nayarit, Mexico (CEBN\/0112017).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All individuals voluntarily participated in the study and gave their informed written consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Written informed consent was obtained from all participants.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}