{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T10:36:27Z","timestamp":1788258987136,"version":"build-2803163510"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T00:00:00Z","timestamp":1668643200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T00:00:00Z","timestamp":1668643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"NOT APPLICABLE","award":["This research did not receive any specific grant from funding agencies in the public"],"award-info":[{"award-number":["This research did not receive any specific grant from funding agencies in the public"]}]},{"name":"NOT APPLICABLE","award":["commercial"],"award-info":[{"award-number":["commercial"]}]},{"name":"NOT APPLICABLE","award":["or not-for-profit sectors."],"award-info":[{"award-number":["or not-for-profit sectors."]}]},{"name":"NA"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"DOI":"10.1007\/s11356-022-23987-6","type":"journal-article","created":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T10:04:06Z","timestamp":1668679446000},"page":"28118-28132","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effect of TLR3\/dsRNA complex inhibitor on Poly(I:C)-induced airway inflammation in Swiss albino mice"],"prefix":"10.1007","volume":"30","author":[{"given":"Swamita","family":"Arora","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangeetha","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wasim","family":"Akram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed E.","family":"Altyar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priti","family":"Tagde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,17]]},"reference":[{"key":"23987_CR1","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","volume":"105","author":"H Aebi","year":"1984","unstructured":"Aebi H (1984) Catalase in vitro. Methods Enzymol 105:121\u2013126. https:\/\/doi.org\/10.1016\/S0076-6879(84)05016-3","journal-title":"Methods Enzymol"},{"key":"23987_CR2","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1038\/35099560","volume":"413","author":"L Alexopoulou","year":"2001","unstructured":"Alexopoulou L, Holt AC, Medzhitov R, Flavell RA (2001) Recognition of double-stranded RNA and activation of NF-\u03baB by Toll-like receptor 3. Nature 413:732\u2013738. https:\/\/doi.org\/10.1038\/35099560","journal-title":"Nature"},{"key":"23987_CR3","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1007\/s00408-022-00564-9","volume":"200","author":"P Aydin","year":"2022","unstructured":"Aydin P, Magden ZBA, Uzuncakmak SK, Halici H, Akgun N, Mendil AS, Mokhtare B, Cadirci E (2022) Avanafil as a novel therapeutic agent against LPS-induced acute lung injury via increasing CGMP to downregulate the TLR4-NF-\u03baB-NLRP3 inflammasome signaling pathway. Lung 200:561\u2013572","journal-title":"Lung"},{"key":"23987_CR4","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1038\/nri2254","volume":"8","author":"PJ Barnes","year":"2008","unstructured":"Barnes PJ (2008) Immunology of asthma and chronic obstructive pulmonary disease. Nat Rev Immunol 8:183\u2013192. https:\/\/doi.org\/10.1038\/nri2254","journal-title":"Nat Rev Immunol"},{"key":"23987_CR5","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1165\/ajrcmb.19.1.2930","volume":"19","author":"DI Blyth","year":"1998","unstructured":"Blyth DI, Pedrick MS, Savage TJ et al (1998) Induction, duration, and resolution of airway goblet cell hyperplasia in a murine model of atopic asthma: effect of concurrent infection with respiratory syncytial virus and response to dexamethasone. Am J Respir Cell Mol Biol 19:38\u201354. https:\/\/doi.org\/10.1165\/ajrcmb.19.1.2930","journal-title":"Am J Respir Cell Mol Biol"},{"key":"23987_CR6","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1111\/jphp.13094","volume":"71","author":"MH Boskabady","year":"2019","unstructured":"Boskabady MH, Kaveh M, Shakeri F et al (2019) Alpha-linolenic acid ameliorates bronchial asthma features in ovalbumin-sensitized rats. J Pharm Pharmacol 71:1089\u20131099. https:\/\/doi.org\/10.1111\/jphp.13094","journal-title":"J Pharm Pharmacol"},{"key":"23987_CR7","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.1007\/s00210-021-02117-y","volume":"394","author":"M Cellat","year":"2021","unstructured":"Cellat M, Kuzu M, \u0130\u015fler CT et al (2021) Tyrosol improves ovalbumin (OVA)-induced asthma in rat model through prevention of airway inflammation. Naunyn-Schmiedeberg\u2019s Arch Pharmacol 394:2061\u20132075. https:\/\/doi.org\/10.1007\/s00210-021-02117-y","journal-title":"Naunyn-Schmiedeberg\u2019s Arch Pharmacol"},{"key":"23987_CR8","first-page":"265","volume":"35","author":"OE Ekpo","year":"2008","unstructured":"Ekpo OE, Pretorius E (2008) Using the BALB\/c asthmatic mouse model to investigate the effects of hydrocortisone and a herbal asthma medicine on animal weight. Scand J Lab Anim Sci 35:265\u2013280","journal-title":"Scand J Lab Anim Sci"},{"key":"23987_CR9","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.jpba.2008.04.028","volume":"48","author":"AA Ensafi","year":"2008","unstructured":"Ensafi AA, Khayamian T, Hasanpour F (2008) Determination of glutathione in hemolysed erythrocyte by flow injection analysis with chemiluminescence detection. J Pharm Biomed Anal 48:140\u2013144. https:\/\/doi.org\/10.1016\/j.jpba.2008.04.028","journal-title":"J Pharm Biomed Anal"},{"key":"23987_CR10","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1165\/rcmb.2002-0055OC","volume":"28","author":"JE Gern","year":"2003","unstructured":"Gern JE, French DA, Grindle KA et al (2003) Double-stranded RNA induces the synthesis of specific chemokines by bronchial epithelial cells. Am J Respir Cell Mol Biol 28:731\u2013737. https:\/\/doi.org\/10.1165\/rcmb.2002-0055OC","journal-title":"Am J Respir Cell Mol Biol"},{"key":"23987_CR11","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1007\/S12016-019-08751-Y\/FIGURES\/7","volume":"57","author":"K Guan","year":"2019","unstructured":"Guan K, Liu B, Wang M et al (2019) Principles of allergen immunotherapy and its clinical application in China: contrasts and comparisons with the USA. Clin Rev Allergy Immunol 57:128\u2013143. https:\/\/doi.org\/10.1007\/S12016-019-08751-Y\/FIGURES\/7","journal-title":"Clin Rev Allergy Immunol"},{"key":"23987_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.106017","volume":"78","author":"M Guan","year":"2020","unstructured":"Guan M, Ma H, Fan X et al (2020) Dexamethasone alleviate allergic airway inflammation in mice by inhibiting the activation of NLRP3 inflammasome. Int Immunopharmacol 78:106017. https:\/\/doi.org\/10.1016\/j.intimp.2019.106017","journal-title":"Int Immunopharmacol"},{"key":"23987_CR13","doi-asserted-by":"publisher","first-page":"5571","DOI":"10.1074\/JBC.M410592200","volume":"280","author":"L Guillot","year":"2005","unstructured":"Guillot L, Le Goffic R, Bloch S et al (2005) Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus. J Biol Chem 280:5571\u20135580. https:\/\/doi.org\/10.1074\/JBC.M410592200","journal-title":"J Biol Chem"},{"key":"23987_CR14","doi-asserted-by":"publisher","first-page":"12542","DOI":"10.1074\/JBC.M310175200","volume":"279","author":"K Karik\u00f3","year":"2004","unstructured":"Karik\u00f3 K, Ni H, Capodici J et al (2004) mRNA is an endogenous ligand for Toll-like receptor 3. J Biol Chem 279:12542\u201312550. https:\/\/doi.org\/10.1074\/JBC.M310175200","journal-title":"J Biol Chem"},{"key":"23987_CR15","doi-asserted-by":"publisher","unstructured":"Kim YY, Lee S, Kim MJ et al (2017) Tyrosol attenuates lipopolysaccharide-induced acute lung injury by inhibiting the inflammatory response and maintaining the alveolar capillary barrier.\u00a0Food Chem Toxicol\u00a0109:526\u2013533. https:\/\/doi.org\/10.1016\/J.FCT.2017.09.053","DOI":"10.1016\/J.FCT.2017.09.053"},{"key":"23987_CR16","doi-asserted-by":"publisher","first-page":"263","DOI":"10.3389\/FMICB.2013.00263\/BIBTEX","volume":"4","author":"M Kudo","year":"2013","unstructured":"Kudo M, Ishigatsubo Y, Aoki I (2013) Pathology of asthma. Front Microbiol 4:263. https:\/\/doi.org\/10.3389\/FMICB.2013.00263\/BIBTEX","journal-title":"Front Microbiol"},{"key":"23987_CR17","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3109\/08830185.2010.529976","volume":"30","author":"H Kumar","year":"2011","unstructured":"Kumar H, Kawai T, Akira S (2011) Pathogen recognition by the innate immune system. Int Rev Immunol 30:16\u201334. https:\/\/doi.org\/10.3109\/08830185.2010.529976","journal-title":"Int Rev Immunol"},{"key":"23987_CR18","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/s11010-017-2981-5","volume":"431","author":"P Kumar","year":"2017","unstructured":"Kumar P, Sulakhiya K, Barua CC, Mundhe N (2017) TNF-\u03b1, IL-6 and IL-10 expressions, responsible for disparity in action of curcumin against cisplatin-induced nephrotoxicity in rats. Mol Cell Biochem 431:113\u2013122. https:\/\/doi.org\/10.1007\/s11010-017-2981-5","journal-title":"Mol Cell Biochem"},{"key":"23987_CR19","doi-asserted-by":"publisher","unstructured":"Kuzu M, Kandemir FM, Yildirim S et al (2018) Morin attenuates doxorubicin-induced heart and brain damage by reducing oxidative stress, inflammation and apoptosis.\u00a0Biomed Pharmacother\u00a0106:443\u2013453. https:\/\/doi.org\/10.1016\/J.BIOPHA.2018.06.161","DOI":"10.1016\/J.BIOPHA.2018.06.161"},{"key":"23987_CR20","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1164\/ajrccm.161.1.9802048","volume":"161","author":"R Louis","year":"2000","unstructured":"Louis R, Lau LCK, Bron AO et al (2000) The relationship between airways inflammation and asthma severity. Am J Respir Crit Care Med 161:9\u201316. https:\/\/doi.org\/10.1164\/ajrccm.161.1.9802048","journal-title":"Am J Respir Crit Care Med"},{"key":"23987_CR21","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265\u2013275. https:\/\/doi.org\/10.1016\/S0021-9258(19)52451-6","journal-title":"J Biol Chem"},{"key":"23987_CR22","doi-asserted-by":"publisher","unstructured":"M T, UN D, P K (2014) Tinospora cordifolia extract modulates COX-2, iNOS, ICAM-1, pro-inflammatory cytokines and redox status in murine model of asthma. J Ethnopharmacol 153:. https:\/\/doi.org\/10.1016\/J.JEP.2014.01.031","DOI":"10.1016\/J.JEP.2014.01.031"},{"key":"23987_CR23","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.ejphar.2010.09.075","volume":"650","author":"SG Mahajan","year":"2011","unstructured":"Mahajan SG, Mehta AA (2011) Suppression of ovalbumin-induced Th2-driven airway inflammation by \u03b2-sitosterol in a guinea pig model of asthma. Eur J Pharmacol 650:458\u2013464. https:\/\/doi.org\/10.1016\/j.ejphar.2010.09.075","journal-title":"Eur J Pharmacol"},{"key":"23987_CR24","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1165\/rcmb.2009-0450OC","volume":"45","author":"K Matsumoto","year":"2011","unstructured":"Matsumoto K, Kan-o K, Eguchi-Tsuda M et al (2011) Essential role of B7\u2013H1 in double-stranded RNA-induced augmentation of an asthma phenotype in mice. Am J Respir Cell Mol Biol 45:31\u201339. https:\/\/doi.org\/10.1165\/rcmb.2009-0450OC","journal-title":"Am J Respir Cell Mol Biol"},{"key":"23987_CR25","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1007\/s12011-019-01955-5","volume":"196","author":"ET Mohammed","year":"2020","unstructured":"Mohammed ET, Safwat GM (2020) Grape seed proanthocyanidin extract mitigates titanium dioxide nanoparticle (TiO2-NPs)\u2013induced hepatotoxicity through TLR-4\/NF-\u03baB signaling pathway. Biol Trace Elem Res 196:579\u2013589","journal-title":"Biol Trace Elem Res"},{"key":"23987_CR26","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.resp.2018.12.001","volume":"260","author":"PB Ninave","year":"2019","unstructured":"Ninave PB, Patil SD (2019) Antiasthmatic potential of Zizyphus jujuba Mill and Jujuboside B. \u2013 possible role in the treatment of asthma. Respir Physiol Neurobiol 260:28\u201336. https:\/\/doi.org\/10.1016\/j.resp.2018.12.001","journal-title":"Respir Physiol Neurobiol"},{"key":"23987_CR27","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","volume":"95","author":"H Ohkawa","year":"1979","unstructured":"Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351\u2013358. https:\/\/doi.org\/10.1016\/0003-2697(79)90738-3","journal-title":"Anal Biochem"},{"key":"23987_CR28","doi-asserted-by":"crossref","unstructured":"O'Neill LAJ, Bryant CE and Doyle SL (2009) Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer. Pharmacol Rev","DOI":"10.1124\/pr.109.001073"},{"key":"23987_CR29","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1292\/JVMS.19-0438","volume":"82","author":"H Shibuta","year":"2020","unstructured":"Shibuta H, Yamana R, Kashimoto J et al (2020) Comparison of the anesthetic effect by the injection route of mixed anesthesia (medetomidine, midazolam and butorphanol) and the effect of this anesthetic agent on the respiratory function. J Vet Med Sci 82:35\u201342. https:\/\/doi.org\/10.1292\/JVMS.19-0438","journal-title":"J Vet Med Sci"},{"key":"23987_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12931-015-0292-5","volume":"16","author":"M Starkhammar","year":"2015","unstructured":"Starkhammar M, Geor\u00e9n SK, Dahl\u00e9n SE et al (2015) TNF\u03b1-blockade stabilizes local airway hyperresponsiveness during TLR-induced exacerbations in murine model of asthma. Respir Res 16:1\u20139. https:\/\/doi.org\/10.1186\/s12931-015-0292-5","journal-title":"Respir Res"},{"key":"23987_CR31","doi-asserted-by":"publisher","unstructured":"Starkhammar M, Larsson O, Kumlien Geor\u00e9n S, et al (2014) Toll-like receptor ligands LPS and poly (I:C) exacerbate airway hyperresponsiveness in a model of airway allergy in mice, independently of inflammation. PLoS ONE 9:. https:\/\/doi.org\/10.1371\/journal.pone.0104114","DOI":"10.1371\/journal.pone.0104114"},{"key":"23987_CR32","doi-asserted-by":"publisher","unstructured":"Stowell NC, Seideman J, Raymond HA, et al (2009) Long-term activation of TLR3 by Poly(I:C) induces inflammation and impairs lung function in mice. https:\/\/doi.org\/10.1186\/1465-9921-10-43","DOI":"10.1186\/1465-9921-10-43"},{"key":"23987_CR33","doi-asserted-by":"publisher","first-page":"L27","DOI":"10.1152\/ajplung.00398.2014","volume":"309","author":"TE Sussan","year":"2015","unstructured":"Sussan TE, Gajghate S, Chatterjee S et al (2015) Nrf2 reduces allergic asthma in mice through enhanced airway epithelial cytoprotective function. Am J Physiol Lung Cell Mol Physiol 309:L27\u2013L36. https:\/\/doi.org\/10.1152\/ajplung.00398.2014","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"23987_CR34","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1258\/00236770460734416","volume":"38","author":"G Szcz\u0229sny","year":"2004","unstructured":"Szcz\u0229sny G, Veihelmann A, Massberg S et al (2004) Long-term anaesthesia using inhalatory isoflurane in different strains of mice - the haemodynamic effects. Lab Anim 38:64\u201369. https:\/\/doi.org\/10.1258\/00236770460734416","journal-title":"Lab Anim"},{"key":"23987_CR35","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1111\/1440-1681.13002","volume":"45","author":"VR Thakur","year":"2018","unstructured":"Thakur VR, Beladiya JV, Chaudagar KK, Mehta AA (2018) An anti-asthmatic activity of natural Toll-like receptor-4 antagonist in OVA-LPS-induced asthmatic rats. Clin Exp Pharmacol Physiol 45:1187\u20131197. https:\/\/doi.org\/10.1111\/1440-1681.13002","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"23987_CR36","doi-asserted-by":"publisher","unstructured":"Thakur VR, Khuman V, Beladiya J V., et al (2019) An experimental model of asthma in rats using ovalbumin and lipopolysaccharide allergens. Heliyon 5:. https:\/\/doi.org\/10.1016\/J.HELIYON.2019.E02864","DOI":"10.1016\/J.HELIYON.2019.E02864"},{"key":"23987_CR37","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.bbi.2018.12.004","volume":"77","author":"AS Warden","year":"2019","unstructured":"Warden AS, Azzam M, DaCosta A et al (2019) Toll-like receptor 3 activation increases voluntary alcohol intake in C57BL\/6J male mice. Brain Behav Immun 77:55\u201365. https:\/\/doi.org\/10.1016\/j.bbi.2018.12.004","journal-title":"Brain Behav Immun"},{"key":"23987_CR38","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1007\/s00011-011-0307-8","volume":"60","author":"S Yan","year":"2011","unstructured":"Yan S, Ci X, Chen N et al (2011) Anti-inflammatory effects of ivermectin in mouse model of allergic asthma. Inflamm Res 60:589\u2013596. https:\/\/doi.org\/10.1007\/s00011-011-0307-8","journal-title":"Inflamm Res"},{"key":"23987_CR39","doi-asserted-by":"crossref","unstructured":"Zhang C, Wang X, Wang C, He C, Ma Q, Li J, Wang W, Xu Y-T and Wang T (2021) Qingwenzhike prescription alleviates acute lung injury induced by LPS via inhibiting TLR4\/NF-kB pathway and NLRP3 inflammasome activation. Front Pharmacol 12","DOI":"10.3389\/fphar.2021.790072"},{"key":"23987_CR40","doi-asserted-by":"publisher","first-page":"140","DOI":"10.3892\/ETM.2015.2897","volume":"11","author":"Y Zou","year":"2016","unstructured":"Zou Y, Wang Y, Bin WS et al (2016) Characteristic expression and significance of CCL19 in different tissue types in chronic rhinosinusitis. Exp Ther Med 11:140. https:\/\/doi.org\/10.3892\/ETM.2015.2897","journal-title":"Exp Ther Med"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-022-23987-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11356-022-23987-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-022-23987-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T05:19:55Z","timestamp":1678252795000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11356-022-23987-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,17]]},"references-count":40,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["23987"],"URL":"https:\/\/doi.org\/10.1007\/s11356-022-23987-6","relation":{},"ISSN":["1614-7499"],"issn-type":[{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,17]]},"assertion":[{"value":"15 August 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 October 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 November 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"To verify the validity of the experimental findings, only 6 mice per group were used per ethical standards, and the tests were conducted by methods approved by R.V. Northland Institute\u2019s Animal Institutional Ethical Committee (no. 1149\/PO\/Re\/S\/07\/CPCSEA). The animals\u2019 development, health, and capacity for food intake were tracked during the whole trial time to ensure their overall wellbeing.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}