{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T21:49:09Z","timestamp":1783547349490,"version":"3.55.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T00:00:00Z","timestamp":1670803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T00:00:00Z","timestamp":1670803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 31873031"],"award-info":[{"award-number":["No. 31873031"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 32172929"],"award-info":[{"award-number":["No. 32172929"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"DOI":"10.1007\/s11356-022-24598-x","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T15:03:16Z","timestamp":1670857396000},"page":"34188-34202","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Ginsenoside Rg1 regulates thiram-induced chondrocytes\u2019 apoptosis and angiogenesis in broiler chickens"],"prefix":"10.1007","volume":"30","author":[{"given":"Huaisen","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Fakhar-e-Alam","family":"Kulyar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmei","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangyuan","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6065-6648","authenticated-orcid":false,"given":"Jiakui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,12]]},"reference":[{"key":"24598_CR1","doi-asserted-by":"crossref","first-page":"12742","DOI":"10.1038\/s41598-021-91471-1","volume":"11","author":"HQ Cao","year":"2021","unstructured":"Cao HQ, Wei W, Xu RR, Cui X (2021) Ginsenoside Rg1 can restore hematopoietic function by inhibiting Bax translocation-mediated mitochondrial apoptosis in aplastic anemia. Sci Rep 11:12742","journal-title":"Sci Rep"},{"key":"24598_CR2","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1111\/j.1745-7254.2008.00868.x","volume":"29","author":"CF Chen","year":"2008","unstructured":"Chen CF, Chiou WF, Zhang JT (2008) Comparison of the pharmacological effects of Panax ginseng and Panax quinquefolium. Acta Pharmacol Sin 29:1103\u20131108","journal-title":"Acta Pharmacol Sin"},{"key":"24598_CR3","doi-asserted-by":"crossref","first-page":"172418","DOI":"10.1016\/j.ejphar.2019.172418","volume":"856","author":"J Chen","year":"2019","unstructured":"Chen J, Zhang X, Liu X, Zhang C, Shang W, Xue J, Chen R, Xing Y, Song D, Xu R (2019) Ginsenoside Rg1 promotes cerebral angiogenesis via the PI3K\/Akt\/mTOR signaling pathway in ischemic mice. Eur J Pharmacol 856:172418","journal-title":"Eur J Pharmacol"},{"key":"24598_CR4","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3390\/nu9030263","volume":"9","author":"W Cheng","year":"2017","unstructured":"Cheng W, Jing J, Wang Z, Wu D, Huang Y (2017) Chondroprotective effects of ginsenoside Rg1 in human osteoarthritis chondrocytes and a rat model of anterior cruciate ligament transection. Nutrients 9:263","journal-title":"Nutrients"},{"key":"24598_CR5","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1093\/cvr\/cvq300","volume":"89","author":"LWT Cheung","year":"2011","unstructured":"Cheung LWT, Leung KW, Wong CKC, Wong RNS, Wong AST (2011) Ginsenoside-Rg1 induces angiogenesis via non-genomic crosstalk of glucocorticoid receptor and fibroblast growth factor receptor-1. Cardiovasc Res 89:419\u2013425","journal-title":"Cardiovasc Res"},{"key":"24598_CR6","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrm3722","volume":"15","author":"PE Czabotar","year":"2014","unstructured":"Czabotar PE, Lessene G, Strasser A, Adams JM (2014) Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy. Nat Rev Mol Cell Biol 15:49\u201363","journal-title":"Nat Rev Mol Cell Biol"},{"key":"24598_CR7","doi-asserted-by":"crossref","first-page":"112981","DOI":"10.1016\/j.ecoenv.2021.112981","volume":"228","author":"Y Ding","year":"2021","unstructured":"Ding Y, Yao W, Kulyar MF-e-A, Mo Q, Pan H, Zhang Y, Ma B, He Y, Zhang M, Hong J (2021) Taurine is an effective therapy against thiram induced tibial dyschondroplasia via HIF-1\u03b1\/VEGFA and \u03b2-catenin\/GSK-3\u03b2 pathways in broilers. Ecotoxicol Environ Saf 228:112981","journal-title":"Ecotoxicol Environ Saf"},{"key":"24598_CR8","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.3389\/fimmu.2018.02889","volume":"9","author":"C Fan","year":"2018","unstructured":"Fan C, Song Q, Wang P, Li Y, Yang M, Yu SY (2018) Neuroprotective effects of Ginsenoside-Rg1 against depression-like behaviors via suppressing glial activation, synaptic deficits, and neuronal apoptosis in rats. Front Immunol 9:2889","journal-title":"Front Immunol"},{"key":"24598_CR9","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S1050-1738(00)00074-8","volume":"10","author":"H-P Gerber","year":"2000","unstructured":"Gerber H-P, Ferrara N (2000) Angiogenesis and bone growth. Trends Cardiovasc Med 10:223\u2013228","journal-title":"Trends Cardiovasc Med"},{"key":"24598_CR10","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.2527\/jas.2007-0738","volume":"86","author":"M Hasky-Negev","year":"2008","unstructured":"Hasky-Negev M, Simsa S, Tong A, Genina O, Ornan EM (2008) Expression of matrix metalloproteinases during vascularization and ossification of normal and impaired avian growth plate. J Anim Sci 86:1306\u20131315","journal-title":"J Anim Sci"},{"key":"24598_CR11","doi-asserted-by":"crossref","first-page":"9089","DOI":"10.1038\/s41598-017-09664-6","volume":"7","author":"S-c Huang","year":"2017","unstructured":"Huang S-c, Rehman MU, Lan Y-f, Qiu G, Zhang H, Iqbal MK, Luo H-q, Mehmood K, Zhang L-h, Li J-k (2017) Tibial dyschondroplasia is highly associated with suppression of tibial angiogenesis through regulating the HIF-1\u03b1\/VEGF\/VEGFR signaling pathway in chickens. Sci Rep 7:9089","journal-title":"Sci Rep"},{"key":"24598_CR12","doi-asserted-by":"crossref","first-page":"3680","DOI":"10.1038\/s41598-018-22109-y","volume":"8","author":"SC Huang","year":"2018","unstructured":"Huang SC, Zhang LH, Zhang JL, Rehman MU, Tong XL, Qiu G, Jiang X, Iqbal M, Shahzad M, Shen YQ, Li JK (2018) Role and regulation of growth plate vascularization during coupling with osteogenesis in tibial dyschondroplasia of chickens. Sci Rep 8:3680","journal-title":"Sci Rep"},{"key":"24598_CR13","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/s12864-022-08494-9","volume":"23","author":"AR Jahejo","year":"2022","unstructured":"Jahejo AR, Bukhari SAR, Rajput N, Kalhoro NH, Leghari IH, Raza SHA, Li Z, Liu WZ, Tian WX (2022) Transcriptome-based biomarker gene screening and evaluation of the extracellular fatty acid-binding protein (Ex-FABP) on immune and angiogenesis-related genes in chicken erythrocytes of tibial dyschondroplasia. BMC Genomics 23:323","journal-title":"BMC Genomics"},{"key":"24598_CR14","doi-asserted-by":"publisher","first-page":"154296","DOI":"10.1016\/j.phymed.2022.154296","volume":"104","author":"MF-e-A Kulyar","year":"2022","unstructured":"Kulyar MF-e-A, Mo Q, Yao W, Ding Y, Yan Z, Du H, Pan H, Li K, Gao J, Shahzad M, Mansoor MK, Iqbal M, Waqas M, Akhtar M, Bhutta ZA, Li J (2022) Chlorogenic acid suppresses miR-460a in the regulation of Bcl-2, causing interleukin-1\u03b2 reduction in thiram exposed chondrocytes via caspase-3\/caspase-7 pathway. Phytomedicine 104:154296. https:\/\/doi.org\/10.1016\/j.phymed.2022.154296","journal-title":"Phytomedicine"},{"key":"24598_CR15","doi-asserted-by":"publisher","first-page":"112059","DOI":"10.1016\/j.ecoenv.2021.112059","volume":"213","author":"MFEA Kulyar","year":"2021","unstructured":"Kulyar MFEA, Yao WY, Ding YM, Du HT, Li K, Zhang LH, Li AY, Huachun P, Waqas M, Mehmood K, Li JK (2021) Cluster of differentiation 147 (CD147) expression is linked with thiram induced chondrocyte\u2019s apoptosis via Bcl-2\/Bax\/Caspase-3 signalling in tibial growth plate under chlorogenic acid repercussion. Ecotoxicol Environ Saf 213:112059. https:\/\/doi.org\/10.1016\/j.ecoenv.2021.112059","journal-title":"Ecotoxicol Environ Saf"},{"issue":"16","key":"24598_CR16","doi-asserted-by":"publisher","first-page":"2028","DOI":"10.3390\/ani12162028","volume":"12","author":"MF Kulyar","year":"2022","unstructured":"Kulyar MF, Yao W, Mo Q, Ding Y, Zhang Y, Gao J, Li K, Pan H, Nawaz S, Shahzad M, Mehmood K, Iqbal M, Akhtar M, Bhutta ZA, Waqas M, Li J, Qi D (2022) Regulatory role of apoptotic and inflammasome related proteins and their possible functional aspect in thiram associated tibial dyschondroplasia of poultry. Animals (Basel) 12(16):2028. https:\/\/doi.org\/10.3390\/ani12162028","journal-title":"Animals (Basel)"},{"key":"24598_CR17","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s10456-011-9235-z","volume":"14","author":"KW Leung","year":"2011","unstructured":"Leung KW, Ng HM, Tang MKS, Wong CCK, Wong RNS, Wong AST (2011) Ginsenoside-Rg1 mediates a hypoxia-independent upregulation of hypoxia-inducible factor-1 alpha to promote angiogenesis. Angiogenesis 14:515\u2013522","journal-title":"Angiogenesis"},{"key":"24598_CR18","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.rvsc.2007.11.008","volume":"84","author":"JK Li","year":"2008","unstructured":"Li JK, Bi DR, Pan SY, Zhang YH, Zhou DH (2008) Effects of high dietary vitamin A supplementation on tibial dyschondroplasia, skin pigmentation and growth performance in avian broilers. Res Vet Sci 84:409\u2013412","journal-title":"Res Vet Sci"},{"key":"24598_CR19","doi-asserted-by":"crossref","first-page":"395","DOI":"10.3892\/mmr.2013.1822","volume":"9","author":"H Li","year":"2014","unstructured":"Li H, Xu JM, Wang X, Yuan GX (2014) Protective effect of ginsenoside Rg1 on lidocaine-induced apoptosis. Mol Med Rep 9:395\u2013400","journal-title":"Mol Med Rep"},{"key":"24598_CR20","doi-asserted-by":"crossref","first-page":"110398","DOI":"10.1016\/j.biopha.2020.110398","volume":"129","author":"J Lin","year":"2020","unstructured":"Lin J, Huang HF, Yang SK, Duan J, Qu SM, Yuan B, Zeng Z (2020) The effect of Ginsenoside Rg1 in hepatic ischemia reperfusion (I\/R) injury ameliorates ischemia-reperfusion-induced liver injury by inhibiting apoptosis. Biomed Pharmacother 129:110398","journal-title":"Biomed Pharmacother"},{"key":"24598_CR21","doi-asserted-by":"crossref","first-page":"133928","DOI":"10.1016\/j.chemosphere.2022.133928","volume":"295","author":"K Liu","year":"2022","unstructured":"Liu K, Li Y, Iqbal M, Tang Z, Zhang H (2022) Thiram exposure in environment: a critical review on cytotoxicity. Chemosphere 295:133928","journal-title":"Chemosphere"},{"key":"24598_CR22","first-page":"1101","volume":"17","author":"VI Lushchak","year":"2018","unstructured":"Lushchak VI, Matviishyn TM, Husak VV, Storey JM, Storey KB (2018) Pesticide toxicity: a mechanistic approach. EXCLI J 17:1101\u20131136","journal-title":"EXCLI J"},{"key":"24598_CR23","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1002\/jbmr.1487","volume":"27","author":"C Maes","year":"2012","unstructured":"Maes C, Araldi E, Haigh K, Khatri R, Van Looveren R, Giaccia AJ, Haigh JJ, Carmeliet G, Schipani E (2012) VEGF-independent cell-autonomous functions of HIF-1\u03b1 regulating oxygen consumption in fetal cartilage are critical for chondrocyte survival. J Bone Miner Res 27:596\u2013609","journal-title":"J Bone Miner Res"},{"key":"24598_CR24","first-page":"3","volume":"146","author":"G Majno","year":"1995","unstructured":"Majno G, Joris I (1995) Apoptosis, oncosis, and necrosis. An overview of cell death. Am J Pathol 146:3\u201315","journal-title":"Am J Pathol"},{"key":"24598_CR25","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1080\/08927014.2017.1404036","volume":"34","author":"SE Martins","year":"2018","unstructured":"Martins SE, Fillmann G, Lillicrap A, Thomas KV (2018) Review: ecotoxicity of organic and organo-metallic antifouling co-biocides and implications for environmental hazard and risk assessments in aquatic ecosystems. Biofouling 34:34\u201352","journal-title":"Biofouling"},{"key":"24598_CR26","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1080\/03079457.2016.1141170","volume":"45","author":"F Nabi","year":"2016","unstructured":"Nabi F, Shahzad M, Liu J, Li K, Han Z, Zhang D, Iqbal MK, Li J (2016) Hsp90 inhibitor celastrol reinstates growth plate angiogenesis in thiram-induced tibial dyschondroplasia. Avian Pathol 45:187\u2013193","journal-title":"Avian Pathol"},{"key":"24598_CR27","doi-asserted-by":"crossref","first-page":"141826","DOI":"10.1155\/2010\/141824","volume":"2010","author":"PA Nnadi","year":"2010","unstructured":"Nnadi PA, George SO (2010) A cross-sectional survey on parasites of chickens in selected villages in the subhumid zones of South-eastern Nigeria. J Parasitol Res 2010:141826","journal-title":"J Parasitol Res"},{"key":"24598_CR28","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/sj.cdd.4400476","volume":"6","author":"AG Porter","year":"1999","unstructured":"Porter AG, Janicke RU (1999) Emerging roles of caspase-3 in apoptosis. Cell Death Differ 6:99\u2013104","journal-title":"Cell Death Differ"},{"key":"24598_CR29","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1093\/ps\/79.7.1009","volume":"79","author":"CA Praul","year":"2000","unstructured":"Praul CA, Ford BC, Gay CV, Pines M, Leach RM (2000) Gene expression and tibial dyschondroplasia. Poult Sci 79:1009\u20131013","journal-title":"Poult Sci"},{"key":"24598_CR30","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.phytochem.2011.02.012","volume":"72","author":"LW Qi","year":"2011","unstructured":"Qi LW, Wang CZ, Yuan CS (2011) Ginsenosides from American ginseng: chemical and pharmacological diversity. Phytochemistry 72:689\u2013699","journal-title":"Phytochemistry"},{"key":"24598_CR31","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature13146","volume":"507","author":"SK Ramasamy","year":"2014","unstructured":"Ramasamy SK, Kusumbe AP, Adams RH (2014) Endothelial Notch activity promotes angiogenesis and osteogenesis in bone. Nature 507:376\u2013380","journal-title":"Nature"},{"key":"24598_CR32","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jcpa.2005.01.005","volume":"133","author":"NC Rath","year":"2005","unstructured":"Rath NC, Richards MP, Huff WE, Huff GR, Balog JM (2005) Changes in the tibial growth plates of chickens with thiram-induced dyschondroplasia. J Comp Pathol 133:41\u201352","journal-title":"J Comp Pathol"},{"key":"24598_CR33","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.3382\/ps.2007-00219","volume":"86","author":"NC Rath","year":"2007","unstructured":"Rath NC, Huff WE, Huff GR (2007) Thiram-induced changes in the expression of genes relating to vascularization and tibial dyschondroplasia. Poult Sci 86:2390\u20132395","journal-title":"Poult Sci"},{"key":"24598_CR34","doi-asserted-by":"crossref","first-page":"104915","DOI":"10.1016\/j.pestbp.2021.104915","volume":"178","author":"S Salam","year":"2021","unstructured":"Salam S, Iqbal Z, Khan AA, Mahmood R (2021) Oral administration of thiram inhibits brush border membrane enzymes, oxidizes proteins and thiols, impairs redox system and causes histological changes in rat intestine: a dose dependent study. Pestic Biochem Physiol 178:104915","journal-title":"Pestic Biochem Physiol"},{"key":"24598_CR35","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1039\/b304710e","volume":"5","author":"VK Sharma","year":"2003","unstructured":"Sharma VK, Aulakh JS, Malik AK (2003) Thiram: degradation, applications and analytical methods. J Environ Monit 5:717\u2013723","journal-title":"J Environ Monit"},{"key":"24598_CR36","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jhazmat.2008.03.074","volume":"161","author":"B Singh","year":"2009","unstructured":"Singh B, Sharma DK, Gupta A (2009) A study towards release dynamics of thiram fungicide from starch-alginate beads to control environmental and health hazards. J Hazard Mater 161:208\u2013216","journal-title":"J Hazard Mater"},{"key":"24598_CR37","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jss.2014.03.067","volume":"191","author":"T Tao","year":"2014","unstructured":"Tao T, Chen F, Bo L, Xie Q, Yi W, Zou Y, Hu B, Li J, Deng X (2014) Ginsenoside Rg1 protects mouse liver against ischemia\u2013reperfusion injury through anti-inflammatory and anti-apoptosis properties. J Surg Res 191:231\u2013238","journal-title":"J Surg Res"},{"key":"24598_CR38","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1186\/1471-2164-14-276","volume":"14","author":"WX Tian","year":"2013","unstructured":"Tian WX, Li JK, Qin P, Wang R, Ning GB, Qiao JG, Li HQ, Bi DR, Pan SY, Guo DZ (2013) Screening of differentially expressed genes in the growth plate of broiler chickens with tibial dyschondroplasia by microarray analysis. BMC Genomics 14:276","journal-title":"BMC Genomics"},{"key":"24598_CR39","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/sj.cr.7310028","volume":"16","author":"MF Van Delft","year":"2006","unstructured":"Van Delft MF, Huang D (2006) How the Bcl-2 family of proteins interact to regulate apoptosis. Cell Res 16:203\u2013213","journal-title":"Cell Res"},{"key":"24598_CR40","doi-asserted-by":"publisher","first-page":"110126","DOI":"10.1016\/j.ecoenv.2019.110126","volume":"190","author":"M Waqas","year":"2020","unstructured":"Waqas M, Qamar H, Zhang JL, Yao WY, Li AY, Wang YP, Iqbal M, Mehmood K, Jiang X, Li JK (2020) Puerarin enhance vascular proliferation and halt apoptosis in thiram-induced avian tibial dyschondroplasia by regulating HIF-1 alpha, TIMP-3 and BCL-2 expressions. Ecotoxicol Environ Saf 190:110126. https:\/\/doi.org\/10.1016\/j.ecoenv.2019.110126","journal-title":"Ecotoxicol Environ Saf"},{"key":"24598_CR41","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s10456-005-9000-2","volume":"8","author":"PY Yue","year":"2005","unstructured":"Yue PY, Wong DY, Ha W-Y, Fung M, Mak NK, Yeung H, Leung HW, Chan K, Liu L, Fan T (2005) Elucidation of the mechanisms underlying the angiogenic effects of ginsenoside Rg1 in vivo and in vitro. Angiogenesis 8:205\u2013216","journal-title":"Angiogenesis"},{"key":"24598_CR42","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.3382\/ps.2013-03420","volume":"92","author":"JP Zhang","year":"2013","unstructured":"Zhang JP, Deng YF, Zhou ZL, Hou JF (2013) Expression and identification of recombinant chicken vascular endothelial growth factor in Pichia pastoris and its role in the pathogenesis of tibial dyschondroplasia. Poult Sci 92:3214\u20133227","journal-title":"Poult Sci"},{"key":"24598_CR43","doi-asserted-by":"crossref","first-page":"28264","DOI":"10.1007\/s11356-018-2824-2","volume":"25","author":"H Zhang","year":"2018","unstructured":"Zhang H, Mehmood K, Jiang X, Yao W, Iqbal M, Waqas M, Rehman MU, Li A, Shen Y, Li J (2018) Effect of tetramethyl thiuram disulfide (thiram) in relation to tibial dyschondroplasia in chickens. Environ Sci Pollut Res Int 25:28264\u201328274","journal-title":"Environ Sci Pollut Res Int"},{"key":"24598_CR44","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ecoenv.2019.03.043","volume":"175","author":"H Zhang","year":"2019","unstructured":"Zhang H, Mehmood K, Jiang X, Li ZX, Yao WY, Zhang JL, Tong XL, Wang YP, Li AY, Waqas M, Iqbal M, Li JK (2019) Identification of differentially expressed MiRNAs profile in a thiram-induced tibial dyschondroplasia. Ecotoxicol Environ Saf 175:83\u201389","journal-title":"Ecotoxicol Environ Saf"},{"key":"24598_CR45","doi-asserted-by":"crossref","first-page":"68288","DOI":"10.1007\/s11356-021-15286-3","volume":"28","author":"J Zhang","year":"2021","unstructured":"Zhang J, Luo B, Liu J, Waqas M, Kulyar MF-e-A, Guo K, Li J (2021) Chlorogenic acid inhibits apoptosis in thiram-induced tibial dyschondroplasia via intrinsic pathway. EnEnviron Sci Pollut Res Int 28:68288\u201368299","journal-title":"EnEnviron Sci Pollut Res Int"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-022-24598-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11356-022-24598-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-022-24598-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T00:24:04Z","timestamp":1679876644000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11356-022-24598-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,12]]},"references-count":45,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["24598"],"URL":"https:\/\/doi.org\/10.1007\/s11356-022-24598-x","relation":{},"ISSN":["1614-7499"],"issn-type":[{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,12]]},"assertion":[{"value":"8 August 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 December 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 December 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All maintenance, handling, and procedures of the experimental animals were performed in accordance with the ethics committee of Huazhong Agricultural University (approval no. 31273519).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}