{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T22:55:04Z","timestamp":1768344904692,"version":"3.49.0"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"14","license":[{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Wuxi Health Commission","award":["BJ2020095"],"award-info":[{"award-number":["BJ2020095"]}]},{"name":"Wuxi Health Commission","award":["HB2020098"],"award-info":[{"award-number":["HB2020098"]}]},{"name":"Wuxi Health Commission","award":["LCZX2021006"],"award-info":[{"award-number":["LCZX2021006"]}]},{"name":"Wuxi Health Commission","award":["M202047"],"award-info":[{"award-number":["M202047"]}]},{"DOI":"10.13039\/501100007289","name":"Nanjing  Medical University","doi-asserted-by":"crossref","award":["NMUMT202002"],"award-info":[{"award-number":["NMUMT202002"]}],"id":[{"id":"10.13039\/501100007289","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"DOI":"10.1007\/s11356-022-25072-4","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T01:02:20Z","timestamp":1672794140000},"page":"39724-39732","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Urinary trihalomethane concentrations and liver function indicators: a cross-sectional study in China"],"prefix":"10.1007","volume":"30","author":[{"given":"Li","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Limei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yamei","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Run","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingying","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianqian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuzhu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2950-4360","authenticated-orcid":false,"given":"Xinliang","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhua","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,1,4]]},"reference":[{"key":"25072_CR1","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.envres.2014.10.018","volume":"136","author":"SS Andra","year":"2015","unstructured":"Andra SS, Charisiadis P, Karakitsios S, Sarigiannis DA, Makris KC (2015) Passive exposures of children to volatile trihalomethanes during domestic cleaning activities of their parents. Environ Res 136:187\u2013195. https:\/\/doi.org\/10.1016\/j.envres.2014.10.018","journal-title":"Environ Res"},{"key":"25072_CR2","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.scitotenv.2014.03.075","volume":"485\u2013486","author":"SS Andra","year":"2014","unstructured":"Andra SS, Charisiadis P, Makris KC (2014) Obesity-mediated association between exposure to brominated trihalomethanes and type II diabetes mellitus: an exploratory analysis. Sci Total Environ 485\u2013486:340\u2013347. https:\/\/doi.org\/10.1016\/j.scitotenv.2014.03.075","journal-title":"Sci Total Environ"},{"key":"25072_CR3","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.envres.2014.09.015","volume":"135","author":"XD Andrianou","year":"2014","unstructured":"Andrianou XD, Charisiadis P, Andra SS, Makris KC (2014) Spatial and seasonal variability of urinary trihalomethanes concentrations in urban settings. Environ Res 135:289\u2013295. https:\/\/doi.org\/10.1016\/j.envres.2014.09.015","journal-title":"Environ Res"},{"issue":"8","key":"25072_CR4","doi-asserted-by":"publisher","first-page":"2743","DOI":"10.1021\/acs.jproteome.6b01061","volume":"16","author":"XD Andrianou","year":"2017","unstructured":"Andrianou XD, Charisiadis P, Makris KC (2017) Coupling urinary trihalomethanes and metabolomic profiles of type II diabetes: a case-control study. J Proteome Res 16(8):2743\u20132751. https:\/\/doi.org\/10.1021\/acs.jproteome.6b01061","journal-title":"J Proteome Res"},{"key":"25072_CR5","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.scitotenv.2015.03.050","volume":"521\u2013522","author":"JB Burch","year":"2015","unstructured":"Burch JB, Everson TM, Seth RK et al (2015) Trihalomethane exposure and biomonitoring for the liver injury indicator, alanine aminotransferase, in the United States population (NHANES 1999\u20132006). Sci Total Environ 521\u2013522:226\u2013234. https:\/\/doi.org\/10.1016\/j.scitotenv.2015.03.050","journal-title":"Sci Total Environ"},{"issue":"4","key":"25072_CR6","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1289\/ehp.1409234","volume":"124","author":"WC Cao","year":"2016","unstructured":"Cao WC, Zeng Q, Luo Y, Chen HX et al (2016) Blood biomarkers of late pregnancy exposure to trihalomethanes in drinking water and fetal growth measures and gestational age in a Chinese cohort. Environ Health Perspect 124(4):536\u2013541. https:\/\/doi.org\/10.1289\/ehp.1409234","journal-title":"Environ Health Perspect"},{"issue":"13","key":"25072_CR7","doi-asserted-by":"publisher","first-page":"4793","DOI":"10.1021\/es070084c","volume":"41","author":"J Caro","year":"2007","unstructured":"Caro J, Gallego M (2007) Assessment of exposure of workers and swimmers to trihalomethanes in an indoor swimming pool. Environ Sci Technol 41(13):4793\u20134798. https:\/\/doi.org\/10.1021\/es070084c","journal-title":"Environ Sci Technol"},{"issue":"11","key":"25072_CR8","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1515\/CCLM.2010.315","volume":"48","author":"F Ceriotti","year":"2010","unstructured":"Ceriotti F, Henny J, Queralt\u00f3 J et al (2010) Common reference intervals for aspartate aminotransferase (AST), alanine aminotransferase (ALT) and \u03b3-glutamyl transferase (GGT) in serum: results from an IFCC multicenter study. Clin Chem Lab Med 48(11):1593\u20131601. https:\/\/doi.org\/10.1515\/CCLM.2010.315","journal-title":"Clin Chem Lab Med"},{"issue":"1","key":"25072_CR9","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1021\/es404220z","volume":"48","author":"P Charisiadis","year":"2014","unstructured":"Charisiadis P, Andra SS, Makris KC, Christodoulou M, Christophi CA, Kargaki S, Stephanou EG (2014) Household cleaning activities as noningestion exposure determinants of urinary trihalomethanes. Environ Sci Technol 48(1):770\u2013780. https:\/\/doi.org\/10.1021\/es404220z","journal-title":"Environ Sci Technol"},{"key":"25072_CR10","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.jchromb.2013.11.060","volume":"947\u2013948","author":"P Charisiadis","year":"2014","unstructured":"Charisiadis P, Makris KC (2014) A sensitive and fast method for trihalomethanes in urine using gas chromatography\u2013triple quadrupole mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 947\u2013948:17\u201322. https:\/\/doi.org\/10.1016\/j.jchromb.2013.11.060","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"25072_CR11","doi-asserted-by":"publisher","first-page":"105335","DOI":"10.1016\/j.envint.2019.105335","volume":"134","author":"YJ Chen","year":"2020","unstructured":"Chen YJ, Duan P, Meng TQ et al (2020) Associations of blood trihalomethanes with semen quality among 1199 healthy Chinese men screened as potential sperm donors. Environ Int 134:105335. https:\/\/doi.org\/10.1016\/j.envint.2019.105335","journal-title":"Environ Int"},{"key":"25072_CR12","doi-asserted-by":"publisher","first-page":"3529149","DOI":"10.1155\/2016\/3529149","volume":"2016","author":"ML Contreras-Zentella","year":"2016","unstructured":"Contreras-Zentella ML, Medicine RH-MJO, Longevity C (2016) Is liver enzyme release really associated with cell necrosis induced by oxidant stress? Oxid Med Cell Longev 2016:3529149. https:\/\/doi.org\/10.1155\/2016\/3529149","journal-title":"Oxid Med Cell Longev"},{"issue":"4","key":"25072_CR13","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1093\/aje\/kwr419","volume":"175","author":"N Costet","year":"2012","unstructured":"Costet N, Garlant\u00e9zec R, Monfort C, Rouget F, Gagni\u00e8re B, Chevrier C, Cordier S (2012) Environmental and urinary markers of prenatal exposure to drinking water disinfection by-products, fetal growth, and duration of gestation in the PELAGIE birth cohort (Brittany, France, 2002\u20132006). Am J Epidemiol 175(4):263\u2013275. https:\/\/doi.org\/10.1093\/aje\/kwr419","journal-title":"Am J Epidemiol"},{"key":"25072_CR14","doi-asserted-by":"publisher","unstructured":"Cristina, Villanueva, Sylvaine, Cordier, Laia, Font-Ribera and Lucas (2015) Overview of disinfection by-products and associated health effects. Curr Environ Health Rep 2(1): 107-115https:\/\/doi.org\/10.1007\/s40572-014-0032-x","DOI":"10.1007\/s40572-014-0032-x"},{"issue":"3","key":"25072_CR15","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.taap.2013.02.003","volume":"269","author":"S Das","year":"2013","unstructured":"Das S, Kumar A, Seth RK et al (2013a) Proinflammatory adipokine leptin mediates disinfection byproduct bromodichloromethane-induced early steatohepatitic injury in obesity. Toxicol Appl Pharmacol 269(3):297\u2013306. https:\/\/doi.org\/10.1016\/j.taap.2013.02.003","journal-title":"Toxicol Appl Pharmacol"},{"issue":"12","key":"25072_CR16","doi-asserted-by":"publisher","first-page":"G950","DOI":"10.1152\/ajpgi.00235.2013","volume":"305","author":"S Das","year":"2013","unstructured":"Das S, Seth RK, Kumar A et al (2013b) Purinergic receptor X7 is a key modulator of metabolic oxidative stress-mediated autophagy and inflammation in experimental nonalcoholic steatohepatitis. Am J Physiol Gastrointest Liver Physiol 305(12):G950-963. https:\/\/doi.org\/10.1152\/ajpgi.00235.2013","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"7","key":"25072_CR17","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1136\/oem.58.7.443","volume":"58","author":"L Dodds","year":"2001","unstructured":"Dodds L, King WD (2001) Relation between trihalomethane compounds and birth defects. Occup Environ Med 58(7):443\u2013446. https:\/\/doi.org\/10.1136\/oem.58.7.443","journal-title":"Occup Environ Med"},{"key":"25072_CR18","doi-asserted-by":"publisher","first-page":"114976","DOI":"10.1016\/j.watres.2019.114976","volume":"165","author":"F Dong","year":"2019","unstructured":"Dong F, Chen J, Li C, Ma X, Jiang J, Lin Q, Lin C, Diao H (2019) Evidence-based analysis on the toxicity of disinfection byproducts in vivo and in vitro for disinfection selection. Water Res 165:114976. https:\/\/doi.org\/10.1016\/j.watres.2019.114976","journal-title":"Water Res"},{"issue":"10","key":"25072_CR19","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.1093\/clinchem\/27.10.1642","volume":"27","author":"BT Doumas","year":"1981","unstructured":"Doumas BT, Bayse DD, Carter RJ (1981) A candidate reference method for determination of total protein in serum I. Dev Valid Clin Chem 27(10):1642\u20131650","journal-title":"Dev Valid Clin Chem"},{"key":"25072_CR20","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.envint.2017.10.003","volume":"110","author":"A Esp\u00edn-P\u00e9rez","year":"2018","unstructured":"Esp\u00edn-P\u00e9rez A, Font-Ribera L, Van Veldhoven K et al (2018) Blood transcriptional and microRNA responses to short-term exposure to disinfection by-products in a swimming pool. Environ Int 110:42\u201350. https:\/\/doi.org\/10.1016\/j.envint.2017.10.003","journal-title":"Environ Int"},{"key":"25072_CR21","doi-asserted-by":"publisher","first-page":"104988","DOI":"10.1016\/j.envint.2019.104988","volume":"131","author":"L Font-Ribera","year":"2019","unstructured":"Font-Ribera L, Marco E, Grimalt JO et al (2019) Exposure to disinfection by-products in swimming pools and biomarkers of genotoxicity and respiratory damage - The PISCINA2 Study. Environ Int 131:104988. https:\/\/doi.org\/10.1016\/j.envint.2019.104988","journal-title":"Environ Int"},{"issue":"1\u20134","key":"25072_CR22","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s10661-010-1672-4","volume":"178","author":"M Fooladvand","year":"2011","unstructured":"Fooladvand M, Ramavandi B, Zandi K et al (2011) Investigation of trihalomethanes formation potential in Karoon River water. Iran Environ Monit Assess 178(1\u20134):63\u201371. https:\/\/doi.org\/10.1007\/s10661-010-1672-4","journal-title":"Iran Environ Monit Assess"},{"issue":"8","key":"25072_CR23","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1093\/clinchem\/29.8.1494","volume":"29","author":"P Fossati","year":"1983","unstructured":"Fossati P, Prencipe L, Berti G (1983) Enzymic creatinine assay: a new colorimetric method based on hydrogen peroxide measurement. Clin Chem 29(8):1494\u20131496","journal-title":"Clin Chem"},{"issue":"2","key":"25072_CR24","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1038\/jes.2017.27","volume":"28","author":"S G\u00e4ngler","year":"2018","unstructured":"G\u00e4ngler S, Makris KC, Bouhamra W, Dockery DW (2018) Coupling external with internal exposure metrics of trihalomethanes in young females from Kuwait and Cyprus. J Expo Sci Environ Epidemiol 28(2):140\u2013146. https:\/\/doi.org\/10.1038\/jes.2017.27","journal-title":"J Expo Sci Environ Epidemiol"},{"key":"25072_CR25","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.chemosphere.2014.08.002","volume":"117","author":"S Guilherme","year":"2014","unstructured":"Guilherme S, Rodriguez MJ (2014) Occurrence of regulated and non-regulated disinfection by-products in small drinking water systems. Chemosphere 117:425\u2013432. https:\/\/doi.org\/10.1016\/j.chemosphere.2014.08.002","journal-title":"Chemosphere"},{"issue":"23","key":"25072_CR26","doi-asserted-by":"publisher","first-page":"2095","DOI":"10.1080\/15287390600631789","volume":"69","author":"S Haddad","year":"2006","unstructured":"Haddad S, Tardif GC, Tardif R (2006) Development of physiologically based toxicokinetic models for improving the human indoor exposure assessment to water contaminants: trichloroethylene and trihalomethanes. J Toxicol Environ Health A 69(23):2095\u20132136. https:\/\/doi.org\/10.1080\/15287390600631789","journal-title":"J Toxicol Environ Health A"},{"issue":"8","key":"25072_CR27","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.1002\/ijc.33351","volume":"148","author":"MM He","year":"2021","unstructured":"He MM, Fang Z, Hang D et al (2021) Circulating liver function markers and colorectal cancer risk: a prospective cohort study in the UK Biobank. Int J Cancer 148(8):1867\u20131878. https:\/\/doi.org\/10.1002\/ijc.33351","journal-title":"Int J Cancer"},{"issue":"1","key":"25072_CR28","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.etap.2013.08.015","volume":"37","author":"DK Ingawale","year":"2014","unstructured":"Ingawale DK, Mandlik SK, Naik SR (2014) Models of hepatotoxicity and the underlying cellular, biochemical and immunological mechanism(s): a critical discussion. Environ Toxicol Pharmaco 37(1):118\u2013133. https:\/\/doi.org\/10.1016\/j.etap.2013.08.015","journal-title":"Environ Toxicol Pharmaco"},{"issue":"4","key":"25072_CR29","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/s0272-6386(96)90168-7","volume":"27","author":"R Joseph","year":"1996","unstructured":"Joseph R, Tria L, Mossey RT et al (1996) Comparison of methods for measuring albumin in peritoneal dialysis and hemodialysis patients. Am J Kidney Dis 27(4):566\u2013572. https:\/\/doi.org\/10.1016\/s0272-6386(96)90168-7","journal-title":"Am J Kidney Dis"},{"issue":"2","key":"25072_CR30","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1053\/jhep.2001.22172","volume":"33","author":"PS Kamath","year":"2001","unstructured":"Kamath PS, Wiesner RH, Malinchoc M et al (2001) A model to predict survival in patients with end-stage liver disease. Hepatology 33(2):464\u2013470. https:\/\/doi.org\/10.1053\/jhep.2001.22172","journal-title":"Hepatology"},{"issue":"1","key":"25072_CR31","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1080\/00039896.1995.9955013","volume":"50","author":"Karl and Cammann","year":"1995","unstructured":"Karl and Cammann (1995) Trihalomethane concentrations in swimmers\u2019 and bath attendants\u2019 blood and urine after swimming or working in indoor swimming pools. Arch Environ Health 50(1):61\u201365. https:\/\/doi.org\/10.1080\/00039896.1995.9955013","journal-title":"Arch Environ Health"},{"issue":"1","key":"25072_CR32","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1080\/009841098158629","volume":"55","author":"TE Keegan","year":"1998","unstructured":"Keegan TE, Simmons JE, Pegram RA (1998) NOAEL and LOAEL determinations of acute hepatotoxicity for chloroform and bromodichloromethane delivered in an aqueous vehicle to F344 rats. J Toxicol Environ Health A 55(1):65\u201375. https:\/\/doi.org\/10.1080\/009841098158629","journal-title":"J Toxicol Environ Health A"},{"issue":"23","key":"25072_CR33","doi-asserted-by":"publisher","first-page":"7175","DOI":"10.1021\/es060353j","volume":"40","author":"SW Krasner","year":"2006","unstructured":"Krasner SW, Weinberg HS (2006) (2006) Occurrence of a new generation of disinfection byproducts. Environ Sci Technol 40(23):7175\u20137185. https:\/\/doi.org\/10.1021\/es060353j","journal-title":"Environ Sci Technol"},{"issue":"1904","key":"25072_CR34","doi-asserted-by":"publisher","first-page":"4077","DOI":"10.1098\/rsta.2009.0108","volume":"367","author":"SW Krasner","year":"2009","unstructured":"Krasner SW (2009) The formation and control of emerging disinfection by-products of health concern. Philos Trans A Math Phys Eng Sci 367(1904):4077\u20134095. https:\/\/doi.org\/10.1098\/rsta.2009.0108","journal-title":"Philos Trans A Math Phys Eng Sci"},{"issue":"4","key":"25072_CR35","doi-asserted-by":"publisher","first-page":"599","DOI":"10.5009\/gnl20171","volume":"15","author":"HA Lee","year":"2021","unstructured":"Lee HA, Jung JY, Lee YS et al (2021) Direct bilirubin is more valuable than total bilirubin for predicting prognosis in patients with liver cirrhosis. Gut Liver 15(4):599\u2013605. https:\/\/doi.org\/10.5009\/gnl20171","journal-title":"Gut Liver"},{"key":"25072_CR36","doi-asserted-by":"publisher","first-page":"105518","DOI":"10.1016\/j.envint.2020.105518","volume":"137","author":"C Liu","year":"2020","unstructured":"Liu C, Wang YX, Chen YJ et al (2020) Blood and urinary biomarkers of prenatal exposure to disinfection byproducts and oxidative stress: a repeated measurement analysis. Environ Int 137:105518. https:\/\/doi.org\/10.1016\/j.envint.2020.105518","journal-title":"Environ Int"},{"issue":"1","key":"25072_CR37","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1186\/s12944-018-0920-4","volume":"17","author":"Y Liu","year":"2018","unstructured":"Liu Y, Zhao P, Cheng M et al (2018) AST to ALT ratio and arterial stiffness in non-fatty liver Japanese population: a secondary analysis based on a cross-sectional study. Lipids Health Dis 17(1):275. https:\/\/doi.org\/10.1186\/s12944-018-0920-4","journal-title":"Lipids Health Dis"},{"issue":"2","key":"25072_CR38","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.talanta.2003.10.049","volume":"63","author":"C Lu","year":"2004","unstructured":"Lu C, Lin JM, Huie CW (2004) Determination of total bilirubin in human serum by chemiluminescence from the reaction of bilirubin and peroxynitrite. Talanta 63(2):333\u2013337. https:\/\/doi.org\/10.1016\/j.talanta.2003.10.049","journal-title":"Talanta"},{"key":"25072_CR39","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1016\/j.envint.2016.04.012","volume":"92\u201393","author":"KC Makris","year":"2016","unstructured":"Makris KC, Andrianou XD, Charisiadis P et al (2016) Association between exposures to brominated trihalomethanes, hepatic injury and type II diabetes mellitus. Environ Int 92\u201393:486\u2013493. https:\/\/doi.org\/10.1016\/j.envint.2016.04.012","journal-title":"Environ Int"},{"issue":"1","key":"25072_CR40","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1136\/gutjnl-2017-314924","volume":"67","author":"PN Newsome","year":"2018","unstructured":"Newsome PN, Cramb R, Davison SM et al (2018) Guidelines on the management of abnormal liver blood tests. Gut 67(1):6\u201319. https:\/\/doi.org\/10.1136\/gutjnl-2017-314924","journal-title":"Gut"},{"issue":"2","key":"25072_CR41","doi-asserted-by":"publisher","first-page":"185","DOI":"10.2166\/wh.2009.073","volume":"7","author":"MJ Nieuwenhuijsen","year":"2009","unstructured":"Nieuwenhuijsen MJ, Smith R, Golfinopoulos S et al (2009) Health impacts of long-term exposure to disinfection by-products in drinking water in Europe: HIWATE. J Water Health 7(2):185\u2013207. https:\/\/doi.org\/10.2166\/wh.2009.073","journal-title":"J Water Health"},{"issue":"1\u20133","key":"25072_CR42","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.mrrev.2007.09.001","volume":"636","author":"SD Richardson","year":"2007","unstructured":"Richardson SD, Plewa MJ, Wagner ED, Schoeny R, Demarini DM (2007) Occurrence, genotoxicity, and carcinogenicity of regulated and emerging disinfection by-products in drinking water: a review and roadmap for research. Mutat Res 636(1\u20133):178\u2013242. https:\/\/doi.org\/10.1016\/j.mrrev.2007.09.001","journal-title":"Mutat Res"},{"issue":"5","key":"25072_CR43","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1289\/ehp.1104347","volume":"120","author":"Z Rivera-Nunez","year":"2012","unstructured":"Rivera-Nunez Z, Wright JM, Blount BC et al (2012) Comparison of trihalomethanes in tap water and blood: a case study in the United States. Environ Health Perspect 120(5):661\u2013667. https:\/\/doi.org\/10.1289\/ehp.1104347","journal-title":"Environ Health Perspect"},{"issue":"2","key":"25072_CR44","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1093\/toxsci\/kft104","volume":"134","author":"RK Seth","year":"2013","unstructured":"Seth RK, Kumar A, Das S et al (2013) Environmental toxin-linked nonalcoholic steat ohepatitis and hepatic metabolic reprogramming in obese mice. Toxicol Sci 134(2):291\u2013303. https:\/\/doi.org\/10.1093\/toxsci\/kft104","journal-title":"Toxicol Sci"},{"key":"25072_CR45","doi-asserted-by":"publisher","first-page":"109399","DOI":"10.1016\/j.cbi.2021.109399","volume":"337","author":"K Sharma","year":"2021","unstructured":"Sharma K, Zajc I, \u017diberna L (2021) Dietary vitamin D equilibrium in serum ameliorates direct bilirubin associated diabetes mellitus. Chem Biol Interact 337:109399. https:\/\/doi.org\/10.1016\/j.cbi.2021.109399","journal-title":"Chem Biol Interact"},{"issue":"3","key":"25072_CR46","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/s0009-2797(85)80137-x","volume":"55","author":"A Tomasi","year":"1985","unstructured":"Tomasi A, Albano E, Biasi F et al (1985) Activation of chloroform and related trihalomethanes to free radical intermediates in isolated hepatocytes and in the rat in vivo as detected by the ESR-spin trapping technique. Chem Biol Interact 55(3):303\u2013316. https:\/\/doi.org\/10.1016\/s0009-2797(85)80137-x","journal-title":"Chem Biol Interact"},{"issue":"1","key":"25072_CR47","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.envint.2005.03.005","volume":"32","author":"V Uyak","year":"2006","unstructured":"Uyak V (2006) Multi-pathway risk assessment of trihalomethanes exposure in Istanbul drinking water supplies. Environ Int 32(1):12\u201321. https:\/\/doi.org\/10.1016\/j.envint.2005.03.005","journal-title":"Environ Int"},{"key":"25072_CR48","doi-asserted-by":"publisher","unstructured":"Villanueva, Cristina M, Gracia-Laved\u00e1n, et al (2011) Exposure to trihalomethanes through different water uses and birth weight, small for gestational age, and preterm delivery in Spain. Environ Health Perspect 119 (12): 1824-1830https:\/\/doi.org\/10.1289\/ehp.1002425","DOI":"10.1289\/ehp.1002425"},{"issue":"2","key":"25072_CR49","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.envres.2006.11.001","volume":"103","author":"CM Villanueva","year":"2007","unstructured":"Villanueva CM, Gagniere B, Monfort C et al (2007) Sources of variability in levels and exposure to trihalomethanes. Environ Res 103(2):211\u2013220. https:\/\/doi.org\/10.1016\/j.envres.2006.11.001","journal-title":"Environ Res"},{"key":"25072_CR50","unstructured":"WHO (2005) Background document for development of WHO guidelines for drinking-water quality. World Health Organization; Geneva, Switzerland. Trihalomethanes in Drinking-water"},{"issue":"10","key":"25072_CR51","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1289\/ehp.1408778","volume":"123","author":"GC Windham","year":"2015","unstructured":"Windham GC, Pinney SM, Voss RW et al (2015) Brominated flame retardants and other persistent organohalogenated compounds in relation to timing of puberty in a longitudinal study of girls. Environ Health Perspect 123(10):1046\u20131052. https:\/\/doi.org\/10.1289\/ehp.1408778","journal-title":"Environ Health Perspect"},{"issue":"Pt 2","key":"25072_CR52","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1016\/j.envint.2018.10.024","volume":"121","author":"L Yang","year":"2018","unstructured":"Yang L, Chen X, She Q et al (2018) Regulation, formation, exposure, and treatment of disinfection by-products (DBPs) in swimming pool waters: a critical review. Environ Int 121(Pt 2):1039\u20131057. https:\/\/doi.org\/10.1016\/j.envint.2018.10.024","journal-title":"Environ Int"},{"key":"25072_CR53","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.scitotenv.2017.01.224","volume":"586","author":"P Yang","year":"2017","unstructured":"Yang P, Zhou B, Cao WC et al (2017) Prenatal exposure to drinking water disinfection by-products and DNA methylation in cord blood. Sci Total Environ 586:313\u2013318. https:\/\/doi.org\/10.1016\/j.scitotenv.2017.01.224","journal-title":"Sci Total Environ"},{"key":"25072_CR54","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.envint.2013.01.016","volume":"54","author":"Q Zeng","year":"2013","unstructured":"Zeng Q, Li M, Xie SH et al (2013) Baseline blood trihalomethanes, semen parameters and serum total testosterone: a cross-sectional study in China. Environ Int 54:134\u2013140. https:\/\/doi.org\/10.1016\/j.envint.2013.01.016","journal-title":"Environ Int"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-022-25072-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11356-022-25072-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-022-25072-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T06:04:09Z","timestamp":1680501849000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11356-022-25072-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,4]]},"references-count":54,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["25072"],"URL":"https:\/\/doi.org\/10.1007\/s11356-022-25072-4","relation":{},"ISSN":["1614-7499"],"issn-type":[{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,4]]},"assertion":[{"value":"16 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 December 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Ethics Committee of Wuxi Center for Disease Control and Prevention.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All included participants gave their written informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All the authors agree to the publication of this paper.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}