{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T17:41:49Z","timestamp":1788284509317,"version":"build-2803163510"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"16","license":[{"start":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T00:00:00Z","timestamp":1675382400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T00:00:00Z","timestamp":1675382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Central Scientific Research Projects for Public Welfare Research Institutes","award":["ZX2022QT020"],"award-info":[{"award-number":["ZX2022QT020"]}]},{"name":"Doctoral Program of Entrepreneurship and Innovation in Jiangsu Province","award":["JSSCBS20211323"],"award-info":[{"award-number":["JSSCBS20211323"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"DOI":"10.1007\/s11356-023-25693-3","type":"journal-article","created":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T09:03:47Z","timestamp":1675415027000},"page":"47168-47181","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Sex-specific effect of urinary metabolites of polycyclic aromatic hydrocarbons on thyroid profiles: results from NHANES 2011\u20132012"],"prefix":"10.1007","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7527-4338","authenticated-orcid":false,"given":"Weilong","family":"Xing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyuan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deling","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,2,3]]},"reference":[{"key":"25693_CR1","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.uclim.2018.08.009","volume":"26","author":"B Ambade","year":"2018","unstructured":"Ambade B (2018) The air pollution during Diwali festival by the burning of fireworks in Jamshedpur city, India. Urban Climate 26:149\u2013160","journal-title":"Urban Climate"},{"issue":"7","key":"25693_CR2","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1007\/s11869-021-01004-y","volume":"14","author":"B Ambade","year":"2021","unstructured":"Ambade B, Kurwadkar S, Sankar TK et al (2021) Emission reduction of black carbon and polycyclic aromatic hydrocarbons during COVID-19 pandemic lockdown. Air Qual Atmos Health 14(7):1081\u20131095","journal-title":"Air Qual Atmos Health"},{"key":"25693_CR3","doi-asserted-by":"publisher","first-page":"114073","DOI":"10.1016\/j.marpolbul.2022.114073","volume":"183","author":"B Ambade","year":"2022","unstructured":"Ambade B, Sethi SS, Kurwadkar S et al (2022b) Accumulation of polycyclic aromatic hydrocarbons (PAHs) in surface sediment residues of Mahanadi River Estuary: abundance, source, and risk assessment. Mar Pollut Bull 183:114073","journal-title":"Mar Pollut Bull"},{"key":"25693_CR4","doi-asserted-by":"crossref","unstructured":"Ambade B,Sethi SS, Chintalacheruvu MR (2022a) Distribution, risk assessment, and source apportionment of polycyclic aromatic hydrocarbons (PAHs) using positive matrix factorization (PMF) in urban soils of East India. Environmental geochemistry and health","DOI":"10.1007\/s10653-022-01223-x"},{"key":"25693_CR5","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.chemosphere.2018.07.023","volume":"210","author":"X Bai","year":"2018","unstructured":"Bai X, Yan L, Ji C et al (2018) A combination of ternary classification models and reporter gene assays for the comprehensive thyroid hormone disruption profiles of 209 polychlorinated biphenyls. Chemosphere 210:312\u2013319","journal-title":"Chemosphere"},{"key":"25693_CR6","doi-asserted-by":"crossref","unstructured":"Calsolaro V,Pasqualetti G,Niccolai F et al (2017) Thyroid disrupting chemicals. Int J Mol Sci 18(12)","DOI":"10.3390\/ijms18122583"},{"key":"25693_CR7","doi-asserted-by":"publisher","first-page":"725950","DOI":"10.3389\/fimmu.2021.725950","volume":"12","author":"Z Chen","year":"2021","unstructured":"Chen Z, Zhang Y, Cui L et al (2021) Presence of anti-thyroid antibodies correlate to worse outcome of anti-NMDAR encephalitis. Front Immunol 12:725950","journal-title":"Front Immunol"},{"key":"25693_CR8","doi-asserted-by":"publisher","first-page":"103522","DOI":"10.1016\/j.critrevonc.2021.103522","volume":"168","author":"T Cheng","year":"2021","unstructured":"Cheng T, Lam AK, Gopalan V (2021) Diet derived polycyclic aromatic hydrocarbons and its pathogenic roles in colorectal carcinogenesis. Crit Rev Oncol Hematol 168:103522","journal-title":"Crit Rev Oncol Hematol"},{"issue":"3","key":"25693_CR9","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1007\/s00216-006-0628-6","volume":"386","author":"T Chetiyanukornkul","year":"2006","unstructured":"Chetiyanukornkul T, Toriba A, Kameda T et al (2006) Simultaneous determination of urinary hydroxylated metabolites of naphthalene, fluorene, phenanthrene, fluoranthene and pyrene as multiple biomarkers of exposure to polycyclic aromatic hydrocarbons. Anal Bioanal Chem 386(3):712\u2013718","journal-title":"Anal Bioanal Chem"},{"issue":"Pt 1","key":"25693_CR10","doi-asserted-by":"publisher","first-page":"131605","DOI":"10.1016\/j.chemosphere.2021.131605","volume":"286","author":"S Dehghani","year":"2022","unstructured":"Dehghani S, Fararouei M, Rafiee A et al (2022) Prenatal exposure to polycyclic aromatic hydrocarbons and effects on neonatal anthropometric indices and thyroid-stimulating hormone in a Middle Eastern population. Chemosphere 286(Pt 1):131605","journal-title":"Chemosphere"},{"issue":"4","key":"25693_CR11","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1210\/er.2009-0002","volume":"30","author":"E Diamanti-Kandarakis","year":"2009","unstructured":"Diamanti-Kandarakis E, Bourguignon JP, Giudice LC et al (2009) Endocrine-disrupting chemicals: an Endocrine Society scientific statement. Endocr Rev 30(4):293\u2013342","journal-title":"Endocr Rev"},{"key":"25693_CR12","doi-asserted-by":"publisher","first-page":"147741","DOI":"10.1016\/j.scitotenv.2021.147741","volume":"789","author":"L Famiyeh","year":"2021","unstructured":"Famiyeh L, Chen K, Xu J et al (2021) A review on analysis methods, source identification, and cancer risk evaluation of atmospheric polycyclic aromatic hydrocarbons. Sci Total Environ 789:147741","journal-title":"Sci Total Environ"},{"issue":"1","key":"25693_CR13","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.envpol.2005.09.013","volume":"142","author":"ML Gentes","year":"2006","unstructured":"Gentes ML, Waldner C, Papp Z et al (2006) Effects of oil sands tailings compounds and harsh weather on mortality rates, growth and detoxification efforts in nestling tree swallows (Tachycineta bicolor). Environ Pollut 142(1):24\u201333","journal-title":"Environ Pollut"},{"key":"25693_CR14","doi-asserted-by":"crossref","unstructured":"Gilbert ME,O'Shaughnessy KL, Axelstad M (2020) Regulation of thyroid-disrupting chemicals to protect the developing brain. Endocrinology 161(10)","DOI":"10.1210\/endocr\/bqaa106"},{"issue":"6","key":"25693_CR15","doi-asserted-by":"publisher","first-page":"2593","DOI":"10.1210\/en.2006-1276","volume":"148","author":"JH Goodman","year":"2007","unstructured":"Goodman JH, Gilbert ME (2007) Modest thyroid hormone insufficiency during development induces a cellular malformation in the corpus callosum: a model of cortical dysplasia. Endocrinology 148(6):2593\u20132597","journal-title":"Endocrinology"},{"issue":"6","key":"25693_CR16","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1002\/em.21866","volume":"55","author":"H Guo","year":"2014","unstructured":"Guo H, Huang K, Zhang X et al (2014) Women are more susceptible than men to oxidative stress and chromosome damage caused by polycyclic aromatic hydrocarbons exposure. Environ Mol Mutagen 55(6):472\u2013481","journal-title":"Environ Mol Mutagen"},{"key":"25693_CR17","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.envpol.2019.05.022","volume":"251","author":"J Han","year":"2019","unstructured":"Han J, Liang Y, Zhao B et al (2019) Polycyclic aromatic hydrocarbon (PAHs) geographical distribution in China and their source, risk assessment analysis. Environ Pollut 251:312\u2013327","journal-title":"Environ Pollut"},{"issue":"5","key":"25693_CR18","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1248\/jhs.53.562","volume":"53","author":"K Hayakawa","year":"2007","unstructured":"Hayakawa K, Onoda Y, Tachikawa C et al (2007) Estrogenic\/antiestrogenic activities of polycyclic aromatic hydrocarbons and their monohydroxylated derivatives by yeast two-hybrid assay. J Health Sci 53(5):562\u2013570","journal-title":"J Health Sci"},{"key":"25693_CR19","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.aquatox.2012.07.007","volume":"124\u2013125","author":"C He","year":"2012","unstructured":"He C, Zuo Z, Shi X et al (2012) Pyrene exposure influences the thyroid development of Sebastiscus marmoratus embryos. Aquatic Toxicology (amsterdam, Netherlands) 124\u2013125:28\u201333","journal-title":"Aquatic Toxicology (amsterdam, Netherlands)"},{"issue":"4","key":"25693_CR20","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1080\/09603123.2015.1135311","volume":"26","author":"RB Jain","year":"2016","unstructured":"Jain RB (2016) Association between polycyclic aromatic hydrocarbons and thyroid function among males and females: data from NHANES 2007\u20132008. Int J Environ Health Res 26(4):405\u2013419","journal-title":"Int J Environ Health Res"},{"key":"25693_CR21","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.envint.2013.07.019","volume":"60","author":"KH Kim","year":"2013","unstructured":"Kim KH, Jahan SA, Kabir E et al (2013) A review of airborne polycyclic aromatic hydrocarbons (PAHs) and their human health effects. Environ Int 60:71\u201380","journal-title":"Environ Int"},{"key":"25693_CR22","doi-asserted-by":"publisher","first-page":"144227","DOI":"10.1016\/j.scitotenv.2020.144227","volume":"762","author":"MJ Kim","year":"2021","unstructured":"Kim MJ, Kim S, Choi S et al (2021) Association of exposure to polycyclic aromatic hydrocarbons and heavy metals with thyroid hormones in general adult population and potential mechanisms. Sci Total Environ 762:144227","journal-title":"Sci Total Environ"},{"issue":"3","key":"25693_CR23","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s10654-021-00721-z","volume":"36","author":"AD Kjaergaard","year":"2021","unstructured":"Kjaergaard AD, Marouli E, Papadopoulou A et al (2021) Thyroid function, sex hormones and sexual function: a Mendelian randomization study. Eur J Epidemiol 36(3):335\u2013344","journal-title":"Eur J Epidemiol"},{"issue":"1","key":"25693_CR24","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1007\/s11356-019-06882-5","volume":"27","author":"A Kumar","year":"2020","unstructured":"Kumar A, Sankar TK, Sethi SS et al (2020b) Characteristics, toxicity, source identification and seasonal variation of atmospheric polycyclic aromatic hydrocarbons over East India. Environ Sci Pollut Res Int 27(1):678\u2013690","journal-title":"Environ Sci Pollut Res Int"},{"key":"25693_CR25","doi-asserted-by":"crossref","unstructured":"Kumar A,Ambade B,Sankar TK et al (2020a) Source identification and health risk assessment of atmospheric PM2.5-bound polycyclic aromatic hydrocarbons in Jamshedpur, India. Sustainable Cities and Society 52","DOI":"10.1016\/j.scs.2019.101801"},{"key":"25693_CR26","doi-asserted-by":"crossref","unstructured":"Lawal AT (2017) Polycyclic aromatic hydrocarbons. A review. Cogent Environmental Science 3(1)","DOI":"10.1080\/23311843.2017.1339841"},{"issue":"7","key":"25693_CR27","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1136\/oem.2010.055681","volume":"68","author":"MS Lee","year":"2011","unstructured":"Lee MS, Magari S, Christiani DC (2011) Cardiac autonomic dysfunction from occupational exposure to polycyclic aromatic hydrocarbons. Occup Environ Med 68(7):474\u2013478","journal-title":"Occup Environ Med"},{"issue":"16","key":"25693_CR28","doi-asserted-by":"publisher","first-page":"5744","DOI":"10.1021\/ac0606094","volume":"78","author":"Z Li","year":"2006","unstructured":"Li Z, Romanoff LC, Trinidad DA et al (2006) Measurement of urinary monohydroxy polycyclic aromatic hydrocarbons using automated liquid-liquid extraction and gas chromatography\/isotope dilution high-resolution mass spectrometry. Anal Chem 78(16):5744\u20135751","journal-title":"Anal Chem"},{"issue":"6","key":"25693_CR29","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1038\/jes.2009.41","volume":"20","author":"Z Li","year":"2010","unstructured":"Li Z, Romanoff LC, Lewin MD et al (2010) Variability of urinary concentrations of polycyclic aromatic hydrocarbon metabolite in general population and comparison of spot, first-morning, and 24-h void sampling. J Eposure Sci Environ Epidemiol 20(6):526\u2013535","journal-title":"J Eposure Sci Environ Epidemiol"},{"key":"25693_CR30","doi-asserted-by":"publisher","first-page":"116158","DOI":"10.1016\/j.envpol.2020.116158","volume":"269","author":"B Liu","year":"2021","unstructured":"Liu B, Chen Y, Li S et al (2021) Relationship between urinary metabolites of polycyclic aromatic hydrocarbons and risk of papillary thyroid carcinoma and nodular goiter: a case-control study in non-occupational populations. Environ Pollut 269:116158","journal-title":"Environ Pollut"},{"issue":"7","key":"25693_CR31","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.amjmed.2005.09.028","volume":"119","author":"N Rodondi","year":"2006","unstructured":"Rodondi N, Aujesky D, Vittinghoff E et al (2006) Subclinical hypothyroidism and the risk of coronary heart disease: a meta-analysis. Am J Med 119(7):541\u2013551","journal-title":"Am J Med"},{"key":"25693_CR32","doi-asserted-by":"publisher","first-page":"117258","DOI":"10.1016\/j.envpol.2021.117258","volume":"285","author":"J Shi","year":"2021","unstructured":"Shi J, Zhao Y, Xue L et al (2021) Urinary metabolites of polycyclic aromatic hydrocarbons after short-term fine particulate matter exposure: a randomized crossover trial of air filtration. Environ Pollut 285:117258","journal-title":"Environ Pollut"},{"issue":"8","key":"25693_CR33","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.1039\/c2em30106g","volume":"14","author":"M Song","year":"2012","unstructured":"Song M, Kim YJ, Park YK et al (2012) Changes in thyroid peroxidase activity in response to various chemicals. J Environ Monit\u202f: JEM 14(8):2121\u20132126","journal-title":"J Environ Monit : JEM"},{"key":"25693_CR34","doi-asserted-by":"publisher","first-page":"145403","DOI":"10.1016\/j.scitotenv.2021.145403","volume":"773","author":"K Sun","year":"2021","unstructured":"Sun K, Song Y, He F et al (2021) A review of human and animals exposure to polycyclic aromatic hydrocarbons: health risk and adverse effects, photo-induced toxicity and regulating effect of microplastics. Sci Total Environ 773:145403","journal-title":"Sci Total Environ"},{"issue":"Pt 1","key":"25693_CR35","doi-asserted-by":"publisher","first-page":"132066","DOI":"10.1016\/j.chemosphere.2021.132066","volume":"287","author":"L Sun","year":"2022","unstructured":"Sun L, Chen T, Wang Z et al (2022) The gender-specific adverse association of polycyclic aromatic hydrocarbons on skeletal muscle mass and strength in the general adults and the possible mechanisms in experimental rats. Chemosphere 287(Pt 1):132066","journal-title":"Chemosphere"},{"issue":"1","key":"25693_CR36","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1006\/abbi.1996.0222","volume":"330","author":"A Taurog","year":"1996","unstructured":"Taurog A, Dorris ML, Doerge DR (1996) Mechanism of simultaneous iodination and coupling catalyzed by thyroid peroxidase. Arch Biochem Biophys 330(1):24\u201332","journal-title":"Arch Biochem Biophys"},{"key":"25693_CR37","doi-asserted-by":"crossref","unstructured":"Vithanage M,Bandara PC,Novo LAB et al (2022) Deposition of trace metals associated with atmospheric particulate matter: environmental fate and health risk assessment. Chemosphere 303","DOI":"10.1016\/j.chemosphere.2022.135051"},{"key":"25693_CR38","doi-asserted-by":"publisher","first-page":"108600","DOI":"10.1016\/j.envres.2019.108600","volume":"177","author":"K Wahlberg","year":"2019","unstructured":"Wahlberg K, Liljedahl ER, Alhamdow A et al (2019) Filaggrin variations are associated with PAH metabolites in urine and DNA alterations in blood. Environ Res 177:108600","journal-title":"Environ Res"},{"issue":"1","key":"25693_CR39","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/s11154-019-09521-z","volume":"21","author":"B Yilmaz","year":"2020","unstructured":"Yilmaz B, Terekeci H, Sandal S et al (2020) Endocrine disrupting chemicals: exposure, effects on human health, mechanism of action, models for testing and strategies for prevention. Rev Endocr Metab Disord 21(1):127\u2013147","journal-title":"Rev Endocr Metab Disord"},{"key":"25693_CR40","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.jad.2021.05.097","volume":"292","author":"L Zhang","year":"2021","unstructured":"Zhang L, Sun J, Zhang D (2021) The relationship between urine polycyclic aromatic hydrocarbons and depressive symptoms in American adults. J Affect Disord 292:227\u2013233","journal-title":"J Affect Disord"},{"issue":"4","key":"25693_CR41","doi-asserted-by":"publisher","first-page":"2519","DOI":"10.1021\/acs.est.1c07767","volume":"56","author":"X Zhang","year":"2022","unstructured":"Zhang X, Sun Y, Gao Y et al (2022) Thyroid dysfunction of zebrafish (Danio rerio) after early-life exposure and discontinued exposure to tetrabromobiphenyl (BB-80) and OH-BB-80. Environ Sci Technol 56(4):2519\u20132528","journal-title":"Environ Sci Technol"},{"issue":"7","key":"25693_CR42","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/j.chemosphere.2009.08.054","volume":"77","author":"P Zhu","year":"2009","unstructured":"Zhu P, Bian Z, Xia Y et al (2009) Relationship between urinary metabolites of polycyclic aromatic hydrocarbons and thyroid hormone levels in Chinese non-occupational exposure adult males. Chemosphere 77(7):883\u2013888","journal-title":"Chemosphere"},{"issue":"12","key":"25693_CR43","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1002\/tox.22638","volume":"33","author":"J Zhu","year":"2018","unstructured":"Zhu J, Zhao LY, Wang XX et al (2018) Identification of hepatotoxicity and renal dysfunction of pyrene in adult male rats. Environ Toxicol 33(12):1304\u20131311","journal-title":"Environ Toxicol"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-023-25693-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11356-023-25693-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-023-25693-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T06:07:01Z","timestamp":1681279621000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11356-023-25693-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,3]]},"references-count":43,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["25693"],"URL":"https:\/\/doi.org\/10.1007\/s11356-023-25693-3","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-2098253\/v1","asserted-by":"object"}]},"ISSN":["1614-7499"],"issn-type":[{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,3]]},"assertion":[{"value":"28 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 January 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The program was approved by the National Center for Health Statistics Ethics Review Board. All of the participants provided written informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}