{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T13:16:14Z","timestamp":1790342174877,"version":"4.1.0"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"18","license":[{"start":{"date-parts":[[2023,2,25]],"date-time":"2023-02-25T00:00:00Z","timestamp":1677283200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,2,25]],"date-time":"2023-02-25T00:00:00Z","timestamp":1677283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100017962","name":"Jiangsu Commission of Health","doi-asserted-by":"publisher","award":["CXTDB 2017016"],"award-info":[{"award-number":["CXTDB 2017016"]}],"id":[{"id":"10.13039\/100017962","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016308","name":"Wuxi Health and Family Planning Commission","doi-asserted-by":"publisher","award":["Q201837"],"award-info":[{"award-number":["Q201837"]}],"id":[{"id":"10.13039\/501100016308","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016308","name":"Wuxi Health and Family Planning Commission","doi-asserted-by":"publisher","award":["Z202016"],"award-info":[{"award-number":["Z202016"]}],"id":[{"id":"10.13039\/501100016308","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016308","name":"Wuxi Health and Family Planning Commission","doi-asserted-by":"publisher","award":["QNRC071"],"award-info":[{"award-number":["QNRC071"]}],"id":[{"id":"10.13039\/501100016308","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016308","name":"Wuxi Health and Family Planning Commission","doi-asserted-by":"publisher","award":["HB2020088"],"award-info":[{"award-number":["HB2020088"]}],"id":[{"id":"10.13039\/501100016308","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016308","name":"Wuxi Health and Family Planning Commission","doi-asserted-by":"publisher","award":["FYKY202204"],"award-info":[{"award-number":["FYKY202204"]}],"id":[{"id":"10.13039\/501100016308","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"DOI":"10.1007\/s11356-023-26065-7","type":"journal-article","created":{"date-parts":[[2023,2,25]],"date-time":"2023-02-25T09:03:18Z","timestamp":1677315798000},"page":"52535-52548","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Perfluoroalkyl substance exposure is associated with asthma and innate immune cell count in US adolescents stratified by sex"],"prefix":"10.1007","volume":"30","author":[{"given":"Zhenzhen","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7487-135X","authenticated-orcid":false,"given":"Ling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,2,25]]},"reference":[{"key":"26065_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2020.105979","author":"Y Ait Bamai","year":"2020","unstructured":"Ait Bamai Y, Goudarzi H, Araki A, Okada E, Kashino I, Miyashita C, Kishi R (2020) Effect of prenatal exposure to per- and polyfluoroalkyl substances on childhood allergies and common infectious diseases in children up to age 7 years: The Hokkaido study on environment and children\u2019s health. Environ Int. https:\/\/doi.org\/10.1016\/j.envint.2020.105979","journal-title":"Environ Int"},{"key":"26065_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.11.008","author":"N Akar-Ghibril","year":"2020","unstructured":"Akar-Ghibril N, Casale T, Custovic A, Phipatanakul W (2020) Allergic endotypes and phenotypes of asthma. J Allergy Clin Immunol Pract. https:\/\/doi.org\/10.1016\/j.jaip.2019.11.008","journal-title":"J Allergy Clin Immunol Pract"},{"key":"26065_CR3","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-020-0836-3","author":"L Anderko","year":"2020","unstructured":"Anderko L (2020) Growing health concerns from perfluoroalkyl substances: public health perspectives and clinical implications. Pediatr Res. https:\/\/doi.org\/10.1038\/s41390-020-0836-3","journal-title":"Pediatr Res"},{"key":"26065_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cppeds.2020.100760","author":"L Anderko","year":"2020","unstructured":"Anderko L, Pennea E (2020) Exposures to per-and polyfluoroalkyl substances (PFAS): Potential risks to reproductive and children\u2019s health. Curr Probl Pediatr Adolesc Health Care. https:\/\/doi.org\/10.1016\/j.cppeds.2020.100760","journal-title":"Curr Probl Pediatr Adolesc Health Care"},{"key":"26065_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2018.11.005","author":"M Averina","year":"2019","unstructured":"Averina M, Brox J, Huber S, Furberg AS, S\u00f8rensen M (2019) Serum perfluoroalkyl substances (PFAS) and risk of asthma and various allergies in adolescents. The Troms\u00f8 study Fit Futures in Northern Norway. Environ Res. https:\/\/doi.org\/10.1016\/j.envres.2018.11.005","journal-title":"Environ Res"},{"key":"26065_CR6","doi-asserted-by":"publisher","DOI":"10.1039\/d0em00077a","author":"R Awad","year":"2020","unstructured":"Awad R, Zhou Y, Nyberg E, Namazkar S, Yongning W, Xiao Q, Sun Y, Zhu Z, Bergman \u00c5, Benskin JP (2020) Emerging per- and polyfluoroalkyl substances (PFAS) in human milk from Sweden and China. Environ Sci Process Impacts. https:\/\/doi.org\/10.1039\/d0em00077a","journal-title":"Environ Sci Process Impacts"},{"key":"26065_CR7","doi-asserted-by":"publisher","DOI":"10.1186\/s12940-019-0541-z","author":"IH Beck","year":"2019","unstructured":"Beck IH, Timmermann CAG, Nielsen F, Schoeters G, J\u00f8hnk C, Kyhl HB, H\u00f8st A, Jensen TK (2019) Association between prenatal exposure to perfluoroalkyl substances and asthma in 5-year-old children in the Odense Child Cohort. Environ Health. https:\/\/doi.org\/10.1186\/s12940-019-0541-z","journal-title":"Environ Health"},{"key":"26065_CR8","doi-asserted-by":"publisher","DOI":"10.1021\/es3034654","author":"S Beesoon","year":"2012","unstructured":"Beesoon S, Genuis SJ, Benskin JP, Martin JW (2012) Exceptionally high serum concentrations of perfluorohexanesulfonate in a Canadian family are linked to home carpet treatment applications. Environ Sci Technol. https:\/\/doi.org\/10.1021\/es3034654","journal-title":"Environ Sci Technol"},{"key":"26065_CR9","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-020-02705-6","author":"GW Choi","year":"2020","unstructured":"Choi GW, Choi EJ, Kim JH, Kang DW, Lee YB, Cho HY (2020) Gender differences in pharmacokinetics of perfluoropentanoic acid using non-linear mixed-effect modeling in rats. Arch Toxicol. https:\/\/doi.org\/10.1007\/s00204-020-02705-6","journal-title":"Arch Toxicol"},{"key":"26065_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2021.10639","author":"L Dalsager","year":"2021","unstructured":"Dalsager L, Christensen N, Halekoh U, Timmermann C, Nielsen F, Kyhl HB, Husby S, Grandjean P, Jensen TK, Andersen HR (2021) Exposure to perfluoroalkyl substances during fetal life and hospitalization for infectious disease in childhood: A study among 1,503 children from the Odense Child Cohort. Environ Int. https:\/\/doi.org\/10.1016\/j.envint.2021.10639","journal-title":"Environ Int"},{"key":"26065_CR11","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmaa018","author":"N Ding","year":"2020","unstructured":"Ding N, Harlow SD, Randolph JF Jr, Loch-Caruso R, Park SK (2020) Perfluoroalkyl and polyfluoroalkyl substances (PFAS) and their effects on the ovary. Hum Reprod Update. https:\/\/doi.org\/10.1093\/humupd\/dmaa018","journal-title":"Hum Reprod Update"},{"key":"26065_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2019.108648","author":"JL Domingo","year":"2019","unstructured":"Domingo JL, Nadal M (2019) Human exposure to per- and polyfluoroalkyl substances (PFAS) through drinking water: A review of the recent scientific literature. Environ Res. https:\/\/doi.org\/10.1016\/j.envres.2019.108648","journal-title":"Environ Res"},{"key":"26065_CR13","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1205351","author":"GH Dong","year":"2013","unstructured":"Dong GH, Tung KY, Tsai CH, Liu MM, Wang D, Liu W, Jin YH, Hsieh WS, Lee YL, Chen PC (2013) Serum polyfluoroalkyl concentrations, asthma outcomes, and immunological markers in a case-control study of Taiwanese children. Environ Health Perspect. https:\/\/doi.org\/10.1289\/ehp.1205351","journal-title":"Environ Health Perspect"},{"key":"26065_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2021.111113","author":"A Erinc","year":"2021","unstructured":"Erinc A, Davis MB, Padmanabhan V, Langen E, Goodrich JM (2021) Considering environmental exposures to per- and polyfluoroalkyl substances (PFAS) as risk factors for hypertensive disorders of pregnancy. Environ Res. https:\/\/doi.org\/10.1016\/j.envres.2021.111113","journal-title":"Environ Res"},{"key":"26065_CR15","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.22","author":"Q Hamid","year":"2003","unstructured":"Hamid Q, Tulic\u2019 MK, Liu MC, Moqbel R (2003) Inflammatory cells in asthma: mechanisms and implications for therapy. J Allergy Clin Immunol. https:\/\/doi.org\/10.1067\/mai.2003.22","journal-title":"J Allergy Clin Immunol"},{"key":"26065_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2012.03.035","author":"D Herzke","year":"2012","unstructured":"Herzke D, Olsson E, Posner S (2012) Perfluoroalkyl and polyfluoroalkyl substances (PFASs) in consumer products in Norway - a pilot study. Chemosphere. https:\/\/doi.org\/10.1016\/j.chemosphere.2012.03.035","journal-title":"Chemosphere"},{"key":"26065_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2018.05.051","author":"M Huang","year":"2018","unstructured":"Huang M, Jiao J, Zhuang P, Chen X, Wang J, Zhang Y (2018) Serum polyfluoroalkyl chemicals are associated with risk of cardiovascular diseases in national US population. Environ Int. https:\/\/doi.org\/10.1016\/j.envint.2018.05.051","journal-title":"Environ Int"},{"key":"26065_CR18","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1306606","author":"O Humblet","year":"2014","unstructured":"Humblet O, Diaz-Ramirez LG, Balmes JR, Pinney SM, Hiatt RA (2014) Perfluoroalkyl chemicals and asthma among children 12\u201319 years of age: NHANES (1999\u20132008). Environ Health Perspect. https:\/\/doi.org\/10.1289\/ehp.1306606","journal-title":"Environ Health Perspect"},{"key":"26065_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2017.10.012","author":"A Impinen","year":"2018","unstructured":"Impinen A, Nygaard UC, L\u00f8drup Carlsen KC, Mowinckel P, Carlsen KH, Haug LS, Granum B (2018a) Prenatal exposure to perfluoralkyl substances (PFASs) associated with respiratory tract infections but not allergy- and asthma-related health outcomes in childhood. Environ Res. https:\/\/doi.org\/10.1016\/j.envres.2017.10.012","journal-title":"Environ Res"},{"key":"26065_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2018.12.041","author":"A Impinen","year":"2018","unstructured":"Impinen A, Longnecker MP, Nygaard UC, London SJ, Ferguson KK, Haug LS, Granum B (2018b) Maternal levels of perfluoroalkyl substances (PFASs) during pregnancy and childhood allergy and asthma related outcomes and infections in the Norwegian Mother and Child (MoBa) cohort. Environ Int. https:\/\/doi.org\/10.1016\/j.envint.2018.12.041","journal-title":"Environ Int"},{"key":"26065_CR21","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.envint.2018.12.041","volume":"164","author":"A Impinen","year":"2019","unstructured":"Impinen A, Longnecker MP, Nygaard UC, London SJ, Ferguson KK, Haug LS, Granum B (2019) Maternal levels of perfluoroalkyl substances (PFASs) during pregnancy and childhood allergy and asthma related outcomes and infections in the Norwegian Mother and Child (MoBa) cohort. Environ Int 164:462\u2013472. https:\/\/doi.org\/10.1016\/j.envint.2018.12.041","journal-title":"Environ Int"},{"key":"26065_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2020.113565","author":"MS Jackson-Browne","year":"2020","unstructured":"Jackson-Browne MS, Eliot M, Patti M, Spanier AJ, Braun JM (2020) PFAS (per- and polyfluoroalkyl substances) and asthma in young children: NHANES 2013\u20132014. Int J Hyg Environ Health. https:\/\/doi.org\/10.1016\/j.ijheh.2020.113565","journal-title":"Int J Hyg Environ Health"},{"key":"26065_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(20)30129-7","author":"LG Kahn","year":"2020","unstructured":"Kahn LG, Philippat C, Nakayama SF, Slama R, Trasande L (2020) Endocrine-disrupting chemicals: implications for human health. Lancet Diabetes Endocrinol. https:\/\/doi.org\/10.1016\/S2213-8587(20)30129-7","journal-title":"Lancet Diabetes Endocrinol"},{"key":"26065_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2016.09.017","author":"SJ Kim","year":"2016","unstructured":"Kim SJ, Heo SH, Lee DS, Hwang IG, Lee YB, Cho HY (2016) Gender differences in pharmacokinetics and tissue distribution of 3 perfluoroalkyl and polyfluoroalkyl substances in rats. Food Chem Toxicol. https:\/\/doi.org\/10.1016\/j.fct.2016.09.017","journal-title":"Food Chem Toxicol"},{"key":"26065_CR25","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-018-2365-y","author":"SJ Kim","year":"2019","unstructured":"Kim SJ, Choi EJ, Choi GW, Lee YB, Cho HY (2019) Exploring sex differences in human health risk assessment for PFNA and PFDA using a PBPK model. Arch Toxicol. https:\/\/doi.org\/10.1007\/s00204-018-2365-y","journal-title":"Arch Toxicol"},{"key":"26065_CR26","volume-title":"Fluorinated surfactants and repellents (2nd edition revised and expanded)","author":"E Kissa","year":"2001","unstructured":"Kissa E (2001) Fluorinated surfactants and repellents (2nd edition revised and expanded). Marcel Dekker, New York"},{"key":"26065_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2018.09.006","author":"J Koponen","year":"2018","unstructured":"Koponen J, Winkens K, Airaksinen R, Berger U, Vestergren R, Cousins IT, Karvonen AM, Pekkanen J, Kiviranta H (2018) Longitudinal trends of per- and polyfluoroalkyl substances in children\u2019s serum. Environ Int. https:\/\/doi.org\/10.1016\/j.envint.2018.09.006","journal-title":"Environ Int"},{"key":"26065_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2019.105259","author":"HE Kvalem","year":"2020","unstructured":"Kvalem HE, Nygaard UC, L\u00f8drupCarlsen KC, Carlsen KH, Haug LS, Granum B (2020) Perfluoroalkyl substances, airways infections, allergy and asthma related health outcomes - implications of gender, exposure period and study design. Environ Int. https:\/\/doi.org\/10.1016\/j.envint.2019.105259","journal-title":"Environ Int"},{"key":"26065_CR29","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.scitotenv.2017.08.094","volume":"612","author":"S Lee","year":"2018","unstructured":"Lee S, Kim S, Park J, Kim HJ, Choi G, Choi S, Kim S, Kim SY, Kim S, Choi K, Moon HB (2018) Perfluoroalkyl substances (PFASs) in breast milk from Korea: Time-course trends, influencing factors, and infant exposure. \u00a0Sci Total Environ 612:286\u2013292. https:\/\/doi.org\/10.1016\/j.scitotenv.2017.08.094","journal-title":"\u00a0Sci Total Environ"},{"key":"26065_CR30","doi-asserted-by":"publisher","DOI":"10.1007\/s40572-018-0173-4","author":"Z Liew","year":"2018","unstructured":"Liew Z, Goudarzi H, Oulhote Y (2018) Developmental exposures to Perfluoroalkyl substances (PFASs): an update of associated health outcomes. Curr Environ Health Rep. https:\/\/doi.org\/10.1007\/s40572-018-0173-4","journal-title":"Curr Environ Health Rep"},{"key":"26065_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2021.106599","author":"MJ Lopez-Espinosa","year":"2021","unstructured":"Lopez-Espinosa MJ, Carrizosa C, Luster MI, Margolick JB, Costa O, Leonardi GS, Fletcher T (2021) Perfluoroalkyl substances and immune cell counts in adults from the Mid-Ohio Valley (USA). Environ Int. https:\/\/doi.org\/10.1016\/j.envint.2021.106599","journal-title":"Environ Int"},{"key":"26065_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2020.110145","author":"Y Luo","year":"2020","unstructured":"Luo Y, Deji Z, Huang Z (2020) Exposure to perfluoroalkyl substances and allergic outcomes in children: A systematic review and meta-analysis. Environ Res. https:\/\/doi.org\/10.1016\/j.envres.2020.110145","journal-title":"Environ Res"},{"key":"26065_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2021.106496","author":"K Luo","year":"2021","unstructured":"Luo K, Liu X, Nian M, Wang Y, Qiu J, Yu H, Chen X, Zhang J (2021) Shanghai Birth Cohort. Environmental exposure to per- and polyfluoroalkyl substances mixture and male reproductive hormones. Environ Int. https:\/\/doi.org\/10.1016\/j.envint.2021.106496","journal-title":"Environ Int"},{"key":"26065_CR34","doi-asserted-by":"publisher","DOI":"10.1111\/pai.13403","author":"N Mallah","year":"2021","unstructured":"Mallah N, Rodriguez-Segade S, Gonzalez-Barcala FJ, Takkouche B (2021) Blood eosinophil count as predictor of asthma exacerbation. A meta-analysis. Pediatr Allergy Immunol. https:\/\/doi.org\/10.1111\/pai.13403","journal-title":"Pediatr Allergy Immunol"},{"key":"26065_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2019.06.005","author":"CB Manzano-Salgado","year":"2019","unstructured":"Manzano-Salgado CB, Granum B, Lopez-Espinosa MJ, Ballester F, I\u00f1iguez C, Gasc\u00f3n M, Mart\u00ednez D, Guxens M, Basterretxea M, Zabaleta C, Schettgen T, Sunyer J, Vrijheid M, Casas M (2019) Prenatal exposure to perfluoroalkyl substances, immune-related outcomes, and lung function in children from a Spanish birth cohort study. Int J Hyg Environ Health. https:\/\/doi.org\/10.1016\/j.ijheh.2019.06.005","journal-title":"Int J Hyg Environ Health"},{"key":"26065_CR36","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.5b02237","author":"UB Mogensen","year":"2015","unstructured":"Mogensen UB, Grandjean P, Nielsen F, Weihe P, Budtz-J\u00f8rgensen E (2015) Breastfeeding as an exposure pathway for Perfluorinated Alkylates. Environ Sci Technol. https:\/\/doi.org\/10.1021\/acs.est.5b02237","journal-title":"Environ Sci Technol"},{"key":"26065_CR37","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b19-00095","author":"T Nabe","year":"2020","unstructured":"Nabe T (2020) Steroid-resistant asthma and neutrophils. Biol Pharm Bull. https:\/\/doi.org\/10.1248\/bpb.b19-00095","journal-title":"Biol Pharm Bull"},{"key":"26065_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2016.08.001","author":"Y Oulhote","year":"2017","unstructured":"Oulhote Y, Shamim Z, Kielsen K, Weihe P, Grandjean P, Ryder LP, Heilmann C (2017) Children\u2019s white blood cell counts in relation to developmental exposures to methylmercury and persistent organic pollutants. Reprod Toxicol. https:\/\/doi.org\/10.1016\/j.reprotox.2016.08.001","journal-title":"Reprod Toxicol"},{"key":"26065_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2022.113157","author":"KU Petersen","year":"2022","unstructured":"Petersen KU, H\u00e6rvig KK, Flachs EM, Bonde JP, Lindh C, Hougaard KS, Toft G, Ramlau-Hansen CH, T\u00f8ttenborg SS (2022) Per- and polyfluoroalkyl substances (PFAS) and male reproductive function in young adulthood; a cross-sectional study. Environ Res. https:\/\/doi.org\/10.1016\/j.envres.2022.113157","journal-title":"Environ Res"},{"key":"26065_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2020.01.001","author":"DJ Piekarski","year":"2020","unstructured":"Piekarski DJ, Diaz KR, McNerney MW (2020) Perfluoroalkyl chemicals in neurological health and disease: Human concerns and animal models. Neurotoxicology. https:\/\/doi.org\/10.1016\/j.neuro.2020.01.001","journal-title":"Neurotoxicology"},{"key":"26065_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2019.05.008","author":"DM Pizzurro","year":"2019","unstructured":"Pizzurro DM, Seeley M, Kerper LE, Beck BD (2019) Interspecies differences in perfluoroalkyl substances (PFAS) toxicokinetics and application to health-based criteria. Regul Toxicol Pharmacol. https:\/\/doi.org\/10.1016\/j.yrtph.2019.05.008","journal-title":"Regul Toxicol Pharmacol"},{"key":"26065_CR42","doi-asserted-by":"publisher","DOI":"10.1021\/es0512475","author":"K Prevedouros","year":"2006","unstructured":"Prevedouros K, Cousins IT, Buck RC, Korzeniowski SH (2006) Sources, fate and transport of perfluorocarboxylates. Environ Sci Technol. https:\/\/doi.org\/10.1021\/es0512475","journal-title":"Environ Sci Technol"},{"key":"26065_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2017.01.025","author":"XD Qin","year":"2017","unstructured":"Qin XD, Qian ZM, Dharmage SC, Perret J, Geiger SD, Rigdon SE, Howard S, Zeng XW, Hu LW, Yang BY, Zhou Y, Li M, Xu SL, Bao WW, Zhang YZ, Yuan P, Wang J, Zhang C, Tian YP, Nian M, Xiao X, Chen W, Lee YL, Dong GH (2017) Association of perfluoroalkyl substances exposure with impaired lung function in children. Environ Res. https:\/\/doi.org\/10.1016\/j.envres.2017.01.025","journal-title":"Environ Res"},{"key":"26065_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2018.05.006","author":"C Radermecker","year":"2018","unstructured":"Radermecker C, Louis R, Bureau F, Marichal T (2018) Role of neutrophils in allergic asthma. Curr Opin Immunol. https:\/\/doi.org\/10.1016\/j.coi.2018.05.006","journal-title":"Curr Opin Immunol"},{"key":"26065_CR45","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfy055","author":"L Ramh\u00f8j","year":"2018","unstructured":"Ramh\u00f8j L, Hass U, Boberg J, Scholze M, Christiansen S, Nielsen F, Axelstad M (2018) Perfluorohexane Sulfonate (PFHxS) and a mixture of endocrine disrupters reduce thyroxine levels and cause Antiandrogenic effects in rats. Toxicol Sci. https:\/\/doi.org\/10.1093\/toxsci\/kfy055","journal-title":"Toxicol Sci"},{"key":"26065_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2017.07.003","author":"A Ray","year":"2017","unstructured":"Ray A, Kolls JK (2017) Neutrophilic inflammation in asthma and association with disease severity. Trends Immunol. https:\/\/doi.org\/10.1016\/j.it.2017.07.003","journal-title":"Trends Immunol"},{"key":"26065_CR47","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2016.04.034","author":"ME Romano","year":"2016","unstructured":"Romano ME, Xu Y, Calafat AM, Yolton K, Chen A, Webster GM, Eliot MN, Howard CR, Lanphear BP, Braun JM (2016) Maternal serum perfluoroalkyl substances during pregnancy and duration of breastfeeding. Environ Res. https:\/\/doi.org\/10.1016\/j.envres.2016.04.034","journal-title":"Environ Res"},{"key":"26065_CR48","doi-asserted-by":"publisher","DOI":"10.1289\/EHP9791","author":"T Schillemans","year":"2022","unstructured":"Schillemans T, Donat-Vargas C, Lindh CH, de Faire U, Wolk A, Leander K, \u00c5kesson A (2022) Per- and Polyfluoroalkyl substances and risk of myocardial infarction and stroke: a nested case-control study in Sweden. Environ Health Perspect. https:\/\/doi.org\/10.1289\/EHP9791","journal-title":"Environ Health Perspect"},{"key":"26065_CR49","doi-asserted-by":"publisher","DOI":"10.1111\/all.12605","author":"LA Smit","year":"2015","unstructured":"Smit LA, Lenters V, H\u00f8yer BB, Lindh CH, Pedersen HS, Liermontova I, J\u00f6nsson BA, Piersma AH, Bonde JP, Toft G, Vermeulen R, Heederik D (2015) Prenatal exposure to environmental chemical contaminants and asthma and eczema in school-age children. Allergy. https:\/\/doi.org\/10.1111\/all.12605","journal-title":"Allergy"},{"key":"26065_CR50","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2015.213","author":"CR Stein","year":"2016","unstructured":"Stein CR, McGovern KJ, Pajak AM, Maglione PJ, Wolff MS (2016) Perfluoroalkyl and polyfluoroalkyl substances and indicators of immune function in children aged 12\u201319 y: National Health and nutrition examination survey. Pediatr Res. https:\/\/doi.org\/10.1038\/pr.2015.213","journal-title":"Pediatr Res"},{"key":"26065_CR51","doi-asserted-by":"publisher","DOI":"10.1111\/all.13985","author":"E Sze","year":"2020","unstructured":"Sze E, Bhalla A, Nair P (2020) Mechanisms and therapeutic strategies for non-T2 asthma. Allergy. https:\/\/doi.org\/10.1111\/all.13985","journal-title":"Allergy"},{"key":"26065_CR52","doi-asserted-by":"publisher","DOI":"10.1007\/s40572-020-00279-0","author":"JT Szilagyi","year":"2020","unstructured":"Szilagyi JT, Avula V, Fry RC (2020) Perfluoroalkyl Substances (PFAS) and their effects on the placenta, pregnancy, and child development: a Potential Mechanistic Role for Placental Peroxisome Proliferator-Activated Receptors (PPARs). Curr Environ Health Rep. https:\/\/doi.org\/10.1007\/s40572-020-00279-0","journal-title":"Curr Environ Health Rep"},{"key":"26065_CR53","doi-asserted-by":"publisher","DOI":"10.1080\/1547691X.2016.1254306","author":"CA Timmermann","year":"2017","unstructured":"Timmermann CA, Budtz-J\u00f8rgensen E, Jensen TK, Osuna CE, Petersen MS, Steuerwald U, Nielsen F, Poulsen LK, Weihe P, Grandjean P (2017) Association between perfluoroalkyl substance exposure and asthma and allergic disease in children as modified by MMR vaccination. J Immunotoxicol. https:\/\/doi.org\/10.1080\/1547691X.2016.1254306","journal-title":"J Immunotoxicol"},{"key":"26065_CR54","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-010-0439-3","author":"X Trier","year":"2011","unstructured":"Trier X, Granby K, Christensen JH (2011) Polyfluorinated surfactants (PFS) in paper and board coatings for food packaging. Environ Sci Pollut Res Int. https:\/\/doi.org\/10.1007\/s11356-010-0439-3","journal-title":"Environ Sci Pollut Res Int"},{"key":"26065_CR55","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.113963","author":"G Van Hulst","year":"2020","unstructured":"Van Hulst G, Batugedara HM, Jorssen J, Louis R, Bureau F, Desmet CJ (2020) Eosinophil diversity in asthma. Biochem Pharmacol. https:\/\/doi.org\/10.1016\/j.bcp.2020.113963","journal-title":"Biochem Pharmacol"},{"key":"26065_CR56","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2011957118","author":"M Wang","year":"2021","unstructured":"Wang M, Li Q, Hou M, Chan LLY, Liu M, Ter SK, Dong T, Xia Y, Chotirmall SH, Fang M (2021) Inactivation of common airborne antigens by perfluoroalkyl chemicals modulates early life allergic asthma. Proc Natl Acad Sci U S A. https:\/\/doi.org\/10.1073\/pnas.2011957118","journal-title":"Proc Natl Acad Sci U S A"},{"key":"26065_CR57","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23201-0","author":"LQ Wang","year":"2022","unstructured":"Wang LQ, Liu T, Yang S, Sun L, Zhao ZY, Li LY, She YC, Zheng YY, Ye XY, Bao Q, Dong GH, Li CW, Cui J (2022) Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome. Nat Commun. https:\/\/doi.org\/10.1038\/s41467-021-23201-0","journal-title":"Nat Commun"},{"key":"26065_CR58","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.01.033","author":"NA Winter","year":"2021","unstructured":"Winter NA, Qin L, Gibson PG, McDonald VM, Baines KJ, Faulkner J, Evans TJ, Fricker M (2021) Sputum mast cell\/basophil gene expression relates to inflammatory and clinical features of severe asthma. J Allergy Clin Immunol. https:\/\/doi.org\/10.1016\/j.jaci.2021.01.033","journal-title":"J Allergy Clin Immunol"},{"key":"26065_CR59","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2020.110450","author":"H Xu","year":"2021","unstructured":"Xu H, Mao Y, Hu Y, Xu B (2021) Association between exposure to polyfluoroalkyl chemicals and increased fractional exhaled nitric oxide in adults. Environ Res. https:\/\/doi.org\/10.1016\/j.envres.2020.110450","journal-title":"Environ Res"},{"key":"26065_CR60","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.10.005","author":"SW Yancey","year":"2017","unstructured":"Yancey SW, Keene ON, Albers FC, Ortega H, Bates S, Bleecker ER, Pavord I (2017) Biomarkers for severe eosinophilic asthma. J Allergy Clin Immunol. https:\/\/doi.org\/10.1016\/j.jaci.2017.10.005","journal-title":"J Allergy Clin Immunol"},{"key":"26065_CR61","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.142365","author":"M Yang","year":"2021","unstructured":"Yang M, Li LY, Qin XD, Ye XY, Yu S, Bao Q, Sun L, Wang ZB, Bloom MS, Jalava P, Hu LW, Yu HY, Zeng XW, Yang BY, Dong GH, Li CW (2021) Perfluorooctanesulfonate and perfluorooctanoate exacerbate airway inflammation in asthmatic mice and in vitro. Sci Total Environ. https:\/\/doi.org\/10.1016\/j.scitotenv.2020.142365","journal-title":"Sci Total Environ"},{"key":"26065_CR62","doi-asserted-by":"publisher","DOI":"10.3724\/SP.J.1123.2020.09023","author":"T Ye","year":"2021","unstructured":"Ye T, Chen Y, Fu J, Zhang A, Fu J (2021) Perfluoroalkyl and polyfluoroalkyl substances in eggs: analytical methods and their application as pollutant bioindicator. Se Pu. https:\/\/doi.org\/10.3724\/SP.J.1123.2020.09023","journal-title":"Se Pu"},{"key":"26065_CR63","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-019-05864-x","author":"X Zeng","year":"2019","unstructured":"Zeng X, Chen Q, Zhang X, Li H, Liu Q, Li C, Ma M, Zhang J, Zhang W, Zhang J, Huang L (2019) Association between prenatal exposure to perfluoroalkyl substances and asthma-related diseases in preschool children. Environ Sci Pollut Res Int. https:\/\/doi.org\/10.1007\/s11356-019-05864-x","journal-title":"Environ Sci Pollut Res Int"},{"key":"26065_CR64","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2022.107239","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Mustieles V, Sun Y, Oulhote Y, Wang YX, Messerlian C (2022) Association between serum per- and polyfluoroalkyl substances concentrations and common cold among children and adolescents in the United States. Environ Int. https:\/\/doi.org\/10.1016\/j.envint.2022.107239","journal-title":"Environ Int"},{"key":"26065_CR65","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2022.134338","author":"Y Zhao","year":"2022","unstructured":"Zhao Y, Liu W, Qu J, Hu S, Zhang L, Zhao M, Wu P, Xue J, Hangbiao J (2022) Per-\/polyfluoroalkyl substance concentrations in human serum and their associations with immune markers of rheumatoid arthritis. Chemosphere. https:\/\/doi.org\/10.1016\/j.chemosphere.2022.134338","journal-title":"Chemosphere"},{"key":"26065_CR66","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-01140-5","author":"Y Zhou","year":"2017","unstructured":"Zhou Y, Hu LW, Qian ZM, Geiger SD, Parrish KL, Dharmage SC, Campbell B, Roponen M, Jalava P, Hirvonen MR, Heinrich J, Zeng XW, Yang BY, Qin XD, Lee YL, Dong GH (2017) Interaction effects of polyfluoroalkyl substances and sex steroid hormones on asthma among children. Sci Rep. https:\/\/doi.org\/10.1038\/s41598-017-01140-5","journal-title":"Sci Rep"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-023-26065-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11356-023-26065-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-023-26065-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T14:50:56Z","timestamp":1682002256000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11356-023-26065-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,25]]},"references-count":66,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["26065"],"URL":"https:\/\/doi.org\/10.1007\/s11356-023-26065-7","relation":{},"ISSN":["1614-7499"],"issn-type":[{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,25]]},"assertion":[{"value":"5 July 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The NHANES protocol was approved by the US National Center for Health Statistics Research Ethics Review Board, and all participants provided informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from the parents or guardians of all minor participants.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}