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In this study, we presented an overview of recent updates on the environmental and health impacts of synthetic pesticides against agro-pest and disease vectors while exhaustive reviewing the potentials of natural plant products from <jats:italic>Zanthoxylum species<\/jats:italic> (<jats:italic>Rutaceae<\/jats:italic>) as sustainable alternatives. This study is expected to spur further research on exploiting these plants and their chemicals as safe and effective pesticide entities to minimize the impact of their chemical and synthetic counterparts on health and the environment.<\/jats:p>\n                <jats:p><jats:bold>Graphical abstract<\/jats:bold><\/jats:p>","DOI":"10.1007\/s11356-023-27258-w","type":"journal-article","created":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T13:01:40Z","timestamp":1683378100000},"page":"67997-68021","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Overhauling the ecotoxicological impact of synthetic pesticides using plants\u2019 natural products: a focus on Zanthoxylum metabolites"],"prefix":"10.1007","volume":"30","author":[{"given":"Innocent Uzochukwu","family":"Okagu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel Sunday","family":"Okeke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wisdom Chinedu Favour","family":"Ezeorba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph Chinedum","family":"Ndefo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7077-3282","authenticated-orcid":false,"given":"Timothy Prince Chidike","family":"Ezeorba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,5,6]]},"reference":[{"issue":"5","key":"27258_CR1","doi-asserted-by":"publisher","first-page":"299","DOI":"10.3390\/TOXINS14050299","volume":"14","author":"A Abbas","year":"2022","unstructured":"Abbas A, Yli-Mattila T (2022) Biocontrol of Fusarium graminearum, a causal agent of Fusarium head blight of wheat, and deoxynivalenol accumulation: from in vitro to in planta. 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