{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T21:02:41Z","timestamp":1791147761960,"version":"4.1.0"},"reference-count":75,"publisher":"Springer Science and Business Media LLC","issue":"34","license":[{"start":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T00:00:00Z","timestamp":1686873600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T00:00:00Z","timestamp":1686873600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"DOI":"10.1007\/s11356-023-28037-3","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T06:02:43Z","timestamp":1686895363000},"page":"82437-82457","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["An evaluation of the effects of mixed heavy metals on prediabetes and type 2 diabetes: epidemiological and toxicogenomic analysis"],"prefix":"10.1007","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8419-7784","authenticated-orcid":false,"given":"Hai Duc","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,6,16]]},"reference":[{"key":"28037_CR1","doi-asserted-by":"crossref","unstructured":"Anetor JI, Uche CZ, Ayita EB, Adedapo SK, Adeleye JO, Anetor GO, Akinlade SK (2016) Cadmium Level, Glycemic Control, and Indices of Renal Function in Treated Type II Diabetics: Implications for Polluted Environments. 4","DOI":"10.3389\/fpubh.2016.00114"},{"key":"28037_CR2","doi-asserted-by":"crossref","unstructured":"Asif MJC (2017) Role of heavy metals in human health and particularly in respect to diabetic patients. 7: 1.1-1.10","DOI":"10.5667\/tang.2014.0033"},{"key":"28037_CR3","unstructured":"Association AD (2021) Understanding A1C: Diagnosis. Book Understanding A1C: Diagnosis, City"},{"key":"28037_CR4","doi-asserted-by":"crossref","first-page":"36625","DOI":"10.1038\/srep36625","volume":"6","author":"T Barta","year":"2016","unstructured":"Barta T, Peskova L, Hampl A (2016) miRNAsong: a web-based tool for generation and testing of miRNA sponge constructs in silico. Sci Rep 6:36625","journal-title":"Sci Rep"},{"key":"28037_CR5","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/biostatistics\/kxu058","volume":"16","author":"JF Bobb","year":"2015","unstructured":"Bobb JF, Valeri L, Claus Henn B, Christiani DC, Wright RO, Mazumdar M, Godleski JJ, Coull BA (2015) Bayesian kernel machine regression for estimating the health effects of multi-pollutant mixtures. Biostatistics 16:493\u2013508","journal-title":"Biostatistics"},{"key":"28037_CR6","doi-asserted-by":"crossref","unstructured":"Bobb JF (2015) Bayesian kernel machine regression for estimating the health effects of multi-pollutant mixtures. Biostatistics; 16","DOI":"10.1093\/biostatistics\/kxu058"},{"key":"28037_CR7","doi-asserted-by":"crossref","unstructured":"Buha A, \u0110uki\u0107-\u0106osi\u0107 D, \u0106ur\u010di\u0107 M, Bulat Z, Antonijevi\u0107 B, Moulis J-M, Goumenou M, Wallace DJT (2020) Emerging links between cadmium exposure and insulin resistance: Human, animal, and cell study data. 8: 63","DOI":"10.3390\/toxics8030063"},{"key":"28037_CR8","volume":"287","author":"J Cai","year":"2022","unstructured":"Cai J, Li Y, Liu S, Liu Q, Min X, Zhang J, Wei Y, Mo X, Lin Y, Tang X et al (2022) Associations between multiple heavy metals exposure and glycated hemoglobin in a Chinese population. Chemosphere 287:132159","journal-title":"Chemosphere"},{"key":"28037_CR9","doi-asserted-by":"crossref","unstructured":"Chang C-W, Wang C-W, Wu D-W, Lee W-H, Chen Y-C, Liu Y-H, Li C-H, Tsai C-C, Lin W-Y, Chen S-CJD et al. (2021) Significant association between blood lead (Pb) level and haemoglobin A1c in non-diabetic population. 47: 101233","DOI":"10.1016\/j.diabet.2021.101233"},{"key":"28037_CR10","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1021\/tx0600705","volume":"19","author":"YW Chen","year":"2006","unstructured":"Chen YW, Huang CF, Tsai KS, Yang RS, Yen CC, Yang CY, Lin-Shiau SY, Liu SH (2006a) Methylmercury induces pancreatic beta-cell apoptosis and dysfunction. Chem Res Toxicol 19:1080\u20131085","journal-title":"Chem Res Toxicol"},{"key":"28037_CR11","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.2337\/db06-0029","volume":"55","author":"YW Chen","year":"2006","unstructured":"Chen YW, Huang CF, Tsai KS, Yang RS, Yen CC, Yang CY, Lin-Shiau SY, Liu SH (2006b) The role of phosphoinositide 3-kinase\/Akt signaling in low-dose mercury-induced mouse pancreatic beta-cell dysfunction in vitro and in vivo. Diabetes 55:1614\u20131624","journal-title":"Diabetes"},{"key":"28037_CR12","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ijheh.2016.10.002","volume":"220","author":"W Choi","year":"2017","unstructured":"Choi W, Kim S, Baek Y-W, Choi K, Lee K, Kim S, Yu SD, Choi K (2017) Exposure to environmental chemicals among Korean adults-updates from the second Korean National Environmental Health Survey (2012\u20132014). Int J Hyg Environ Health 220:29\u201335","journal-title":"Int J Hyg Environ Health"},{"key":"28037_CR13","doi-asserted-by":"crossref","unstructured":"Dawson PAJPotgt (2018) Bile formation and the enterohepatic circulation. 931-56","DOI":"10.1016\/B978-0-12-809954-4.00041-4"},{"key":"28037_CR14","doi-asserted-by":"crossref","unstructured":"Duc HN, Oh H, Kim M-S (2021a) The Effect of Mixture of Heavy Metals on Obesity in Individuals \u226550 Years of Age. Biological Trace Element Research","DOI":"10.1007\/s12011-021-02972-z"},{"key":"28037_CR15","doi-asserted-by":"crossref","unstructured":"Duc HN, Oh H, Kim MS (2021b) Effects of Antioxidant Vitamins, Curry Consumption, and Heavy Metal Levels on Metabolic Syndrome with Comorbidities: A Korean Community-Based Cross-Sectional Study. Antioxidants (Basel); 10","DOI":"10.21203\/rs.3.rs-225694\/v1"},{"key":"28037_CR16","volume":"10","author":"HN Duc","year":"2021","unstructured":"Duc HN, Oh H, Yoon IM, Kim M-S (2021c) Association between levels of thiamine intake, diabetes, cardiovascular diseases and depression in Korea: a national cross-sectional study. J Nutrition Sci 10:e31","journal-title":"J Nutrition Sci"},{"key":"28037_CR17","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108736","volume":"108","author":"H Duc Nguyen","year":"2022","unstructured":"Duc Nguyen H, Hee Jo W, Hong Minh Hoang N, Kim M-S (2022a) Anti-inflammatory effects of B vitamins protect against tau hyperphosphorylation and cognitive impairment induced by 1,2 diacetyl benzene: An in vitro and in silico study. Int Immunopharmacol 108:108736","journal-title":"Int Immunopharmacol"},{"key":"28037_CR18","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.108428","volume":"102","author":"H Duc Nguyen","year":"2022","unstructured":"Duc Nguyen H, Oh H, Kim M-S (2022b) Association between exposure to chemical mixtures in relation to serum total IgE among adults 19\u201386 years old. Int Immunopharmacol 102:108428","journal-title":"Int Immunopharmacol"},{"key":"28037_CR19","doi-asserted-by":"crossref","unstructured":"Edwards J, Ackerman CJCDR (2016) A review of diabetes mellitus and exposure to the environmental toxicant cadmium with an emphasis on likely mechanisms of action. 12: 252-58","DOI":"10.2174\/1573399811666150812142922"},{"key":"28037_CR20","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106920","volume":"158","author":"T Filippini","year":"2022","unstructured":"Filippini T, Wise LA, Vinceti M (2022) Cadmium exposure and risk of diabetes and prediabetes: A systematic review and dose-response meta-analysis. Environ Int 158:106920","journal-title":"Environ Int"},{"key":"28037_CR21","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1463-1326.2005.00496.x","volume":"8","author":"LE Fridlyand","year":"2006","unstructured":"Fridlyand LE, Philipson LH (2006) Reactive species and early manifestation of insulin resistance in type 2 diabetes. Diabetes Obes Metab 8:136\u2013145","journal-title":"Diabetes Obes Metab"},{"key":"28037_CR22","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.metabol.2016.01.001","volume":"65","author":"JM Hazlehurst","year":"2016","unstructured":"Hazlehurst JM, Woods C, Marjot T, Cobbold JF, Tomlinson JW (2016) Non-alcoholic fatty liver disease and diabetes. Metab Clin Exp 65:1096\u20131108","journal-title":"Metab Clin Exp"},{"key":"28037_CR23","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.2337\/dc12-1842","volume":"36","author":"K He","year":"2013","unstructured":"He K, Xun P, Liu K, Morris S, Reis J, Guallar E (2013) Mercury exposure in young adulthood and incidence of diabetes later in life: the CARDIA Trace Element Study. Diabetes Care 36:1584\u20131589","journal-title":"Diabetes Care"},{"key":"28037_CR24","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1615\/CritRevEukaryotGeneExpr.2021037971","volume":"31","author":"A Javaid","year":"2021","unstructured":"Javaid A, Akbar I, Javed H, Khan U, Iftikhar H, Zahra D, Rashid F, Ashfaq UA (2021) Role of Heavy Metals in Diabetes: Mechanisms and Treatment Strategies. Crit Rev Eukaryot Gene Expr 31:65\u201380","journal-title":"Crit Rev Eukaryot Gene Expr"},{"key":"28037_CR25","doi-asserted-by":"crossref","first-page":"e039541","DOI":"10.1136\/bmjopen-2020-039541","volume":"11","author":"JH Ji","year":"2021","unstructured":"Ji JH, Jin MH, Kang J-H, Lee SI, Lee S, Kim S-H, Oh SY (2021a) Relationship between heavy metal exposure and type 2 diabetes: a large-scale retrospective cohort study using occupational health examinations. BMJ Open 11:e039541\u2013e039e41","journal-title":"BMJ Open"},{"key":"28037_CR26","volume":"11","author":"JH Ji","year":"2021","unstructured":"Ji JH, Jin MH, Kang JH, Lee SI, Lee S, Kim SH, Oh SY (2021b) Relationship between heavy metal exposure and type 2 diabetes: a large-scale retrospective cohort study using occupational health examinations. BMJ Open 11:e039541","journal-title":"BMJ Open"},{"key":"28037_CR27","first-page":"6809703","volume":"2016","author":"AM Kay","year":"2016","unstructured":"Kay AM, Simpson CL, Stewart JA Jr (2016) The Role of AGE\/RAGE Signaling in Diabetes-Mediated Vascular Calcification. J Diabetes Res 2016:6809703\u20136809703","journal-title":"J Diabetes Res"},{"key":"28037_CR28","doi-asserted-by":"crossref","unstructured":"Keil Alexander P, Buckley Jessie P, O\u2019Brien Katie M, Ferguson Kelly K, Zhao S, White AJ (n.d.) A Quantile-Based g-Computation Approach to Addressing the Effects of Exposure Mixtures. Environ Health Perspect 128:047004","DOI":"10.1289\/EHP5838"},{"key":"28037_CR29","doi-asserted-by":"crossref","unstructured":"Keil AP, Buckley JP, O\u2019Brien KM, Ferguson KK, Zhao S, White AJJEhp (2020) A quantile-based g-computation approach to addressing the effects of exposure mixtures. 128: 047004","DOI":"10.1289\/EHP5838"},{"key":"28037_CR30","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1080\/15476286.2019.1673117","volume":"17","author":"R Khan","year":"2020","unstructured":"Khan R, Kadamkode V, Kesharwani D, Purkayastha S, Banerjee G, Datta M (2020) Circulatory miR-98-5p levels are deregulated during diabetes and it inhibits proliferation and promotes apoptosis by targeting PPP1R15B in keratinocytes. RNA Biol 17:188\u2013201","journal-title":"RNA Biol"},{"key":"28037_CR31","doi-asserted-by":"crossref","unstructured":"Kim DW, Ock J, Moon KW, Park CH (2021) Association between Pb, Cd, and Hg Exposure and Liver Injury among Korean Adults. Intl J Environ Res Public Health 18","DOI":"10.3390\/ijerph18136783"},{"key":"28037_CR32","unstructured":"Klaassen CD (2013) Casarett and Doull's toxicology: the basic science of poisons: McGraw-Hill New York"},{"key":"28037_CR33","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/ije\/dyt228","volume":"43","author":"S Kweon","year":"2014","unstructured":"Kweon S, Kim Y, Jang MJ, Kim Y, Kim K, Choi S, Chun C, Khang YH, Oh K (2014) Data resource profile: the Korea National Health and Nutrition Examination Survey (KNHANES). Int J Epidemiol 43:69\u201377","journal-title":"Int J Epidemiol"},{"key":"28037_CR34","doi-asserted-by":"crossref","unstructured":"Lee A-T, Yang M-Y, Lee Y-J, Yang T-W, Wang C-C, Wang C-J (2022) Gallic Acid Improves Diabetic Steatosis by Downregulating MicroRNA-34a-5p through Targeting NFE2L2 Expression in High-Fat Diet-Fed db\/db Mice. Antioxidants; 11","DOI":"10.3390\/antiox11010092"},{"key":"28037_CR35","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3390\/toxics6030054","volume":"6","author":"T Leff","year":"2018","unstructured":"Leff T, Stemmer P, Tyrrell J, Jog R (2018) Diabetes and Exposure to Environmental Lead (Pb). Toxics 6:54","journal-title":"Toxics"},{"key":"28037_CR36","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1186\/s12859-019-3105-x","volume":"20","author":"V Licursi","year":"2019","unstructured":"Licursi V, Conte F, Fiscon G, Paci P (2019) MIENTURNET: an interactive web tool for microRNA-target enrichment and network-based analysis. BMC Bioinformatics 20:545","journal-title":"BMC Bioinformatics"},{"key":"28037_CR37","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.3892\/ol.2020.11707","volume":"20","author":"S Liu","year":"2020","unstructured":"Liu S, Zhou Y, Zhou Y, Wang J, Ji R (2020) Mechanism of miR-98 inhibiting tumor proliferation and invasion by targeting IGF1R in diabetic patients combined with colon cancer. Oncol Lett 20:1719\u20131726","journal-title":"Oncol Lett"},{"key":"28037_CR38","doi-asserted-by":"crossref","first-page":"8887","DOI":"10.1038\/s41598-019-43793-4","volume":"9","author":"N Mononen","year":"2019","unstructured":"Mononen N, Lyytik\u00e4inen L-P, Sepp\u00e4l\u00e4 I, Mishra PP, Juonala M, Waldenberger M, Klopp N, Illig T, Leivisk\u00e4 J, Loo B-M et al (2019) Whole blood microRNA levels associate with glycemic status and correlate with target mRNAs in pathways important to type 2 diabetes. Sci Rep 9:8887\u20138887","journal-title":"Sci Rep"},{"key":"28037_CR39","doi-asserted-by":"crossref","first-page":"e143","DOI":"10.1111\/dme.12103","volume":"30","author":"SS Moon","year":"2013","unstructured":"Moon SS (2013) Association of lead, mercury and cadmium with diabetes in the Korean population: the Korea National Health and Nutrition Examination Survey (KNHANES) 2009-2010. Diabet Med 30:e143\u2013e148","journal-title":"Diabet Med"},{"key":"28037_CR40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/GME.0000000000001680","volume":"28","author":"HD Nguyen","year":"2021","unstructured":"Nguyen HD, Kim M-S (2021) Effects of heavy metal, vitamin, and curry consumption on metabolic syndrome during menopause: a Korean community-based cross-sectional study. J Menopause 28:1","journal-title":"J Menopause"},{"key":"28037_CR41","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.119780","volume":"309","author":"HD Nguyen","year":"2022","unstructured":"Nguyen HD (2022a) Cadmium, lead, and mercury mixtures interact with non-alcoholic fatty liver diseases. Environ Pollut 309:119780","journal-title":"Environ Pollut"},{"key":"28037_CR42","doi-asserted-by":"crossref","unstructured":"Nguyen HD (2022b) Effects of chemical mixtures on liver function biomarkers in the Korean adult population: thresholds and molecular mechanisms for non-alcoholic fatty liver disease involved. Environ Sci Pollut Res","DOI":"10.1007\/s11356-022-21090-4"},{"key":"28037_CR43","doi-asserted-by":"crossref","unstructured":"Nguyen HD . (2022c) Effects of heavy metals on cardiovascular diseases in pre and post-menopausal women: from big data to molecular mechanism involved. Environ Sci Pollut Res","DOI":"10.1007\/s11356-022-21208-8"},{"key":"28037_CR44","doi-asserted-by":"crossref","unstructured":"Nguyen HD (2022d) Exposure to a mixture of heavy metals induces cognitive impairment: genes and microRNAs involved. Toxicology; 153164","DOI":"10.1016\/j.tox.2022.153164"},{"key":"28037_CR45","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2022.109326","volume":"727","author":"HD Nguyen","year":"2022","unstructured":"Nguyen HD (2022e) The protective effects of curcumin on metabolic syndrome and its components: In-silico analysis for genes, transcription factors, and microRNAs involved. Arch Biochem Biophys 727:109326","journal-title":"Arch Biochem Biophys"},{"key":"28037_CR46","doi-asserted-by":"crossref","unstructured":"Nguyen HD (2022f) The protective effects of curcumin on metabolic syndrome and its components: In-silico analysis for genes, transcription factors, and microRNAs involved. Arch Biochem Biophys 109326","DOI":"10.1016\/j.abb.2022.109326"},{"key":"28037_CR47","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jpsychires.2022.06.006","volume":"152","author":"HD Nguyen","year":"2022","unstructured":"Nguyen HD (2022g) The role of mixed B vitamin intakes on cognitive performance: Modeling, genes and miRNAs involved. J Psychiatr Res 152:38\u201356","journal-title":"J Psychiatr Res"},{"key":"28037_CR48","doi-asserted-by":"crossref","unstructured":"Nguyen HD (2022h) The effects of chemical mixtures on lipid profiles in the Korean adult population: threshold and molecular mechanisms for dyslipidemia involved. Environ Sci Pollut Res","DOI":"10.1007\/s11356-022-18871-2"},{"key":"28037_CR49","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jad.2021.12.133","volume":"301","author":"HD Nguyen","year":"2022","unstructured":"Nguyen HD (2022i) Mixtures modeling identifies vitamin B1 and B3 intakes associated with depression. J Affect Disord 301:68\u201380","journal-title":"J Affect Disord"},{"key":"28037_CR50","doi-asserted-by":"crossref","unstructured":"Nguyen HD (2021) Higher intakes of nutrients are linked with a lower risk of cardiovascular diseases, type 2 diabetes mellitus, arthritis, and depression among Korean adults. Nutrition Research","DOI":"10.1016\/j.nutres.2021.11.003"},{"key":"28037_CR51","doi-asserted-by":"crossref","first-page":"14664","DOI":"10.1038\/s41598-021-94158-9","volume":"11","author":"HD Nguyen","year":"2021","unstructured":"Nguyen HD, Oh H, Hoang NHM, Kim M-S (2021a) Association between heavy metals, high-sensitivity C-reaction protein and 10-year risk of cardiovascular diseases among adult Korean population. Sci Rep 11:14664","journal-title":"Sci Rep"},{"key":"28037_CR52","doi-asserted-by":"crossref","unstructured":"Nguyen HD, Oh H, Hoang NHM, Kim MS (2021b) Association between heavy metals, high-sensitivity C-reaction protein and 10-year risk of cardiovascular diseases among adult Korean population. Sci Rep 11","DOI":"10.1038\/s41598-021-94158-9"},{"key":"28037_CR53","doi-asserted-by":"crossref","unstructured":"Nguyen HD, Oh H, Jo WH, Hoang NHM, Kim MS (2021c) Mixtures modeling identifies heavy metals and pyrethroid insecticide metabolites associated with obesity. Environ Sci Pollut Res Intl","DOI":"10.1007\/s11356-021-16936-2"},{"key":"28037_CR54","doi-asserted-by":"crossref","unstructured":"Nguyen HD, Oh H, Kim M-S (2021d) Effects of heavy metals on hypertension during menopause: a Korean community-based cross-sectional study. Menopause 28","DOI":"10.1097\/GME.0000000000001865"},{"key":"28037_CR55","doi-asserted-by":"crossref","unstructured":"Nguyen HD, Oh H, Kim MS (2021e) Effects of heavy metals on hypertension during menopause: a Korean community-based cross-sectional study. Menopause","DOI":"10.1097\/GME.0000000000001865"},{"key":"28037_CR56","doi-asserted-by":"crossref","unstructured":"Nie X, Wang N, Chen Y, Chen C, Han B, Zhu C, Chen Y, Xia F, Cang Z, Lu MJES et al. (2016) Blood cadmium in Chinese adults and its relationships with diabetes and obesity. 23: 18714-23","DOI":"10.1007\/s11356-016-7078-2"},{"key":"28037_CR57","doi-asserted-by":"crossref","first-page":"5865","DOI":"10.4049\/jimmunol.171.11.5865","volume":"171","author":"Y Oikawa","year":"2003","unstructured":"Oikawa Y, Shimada A, Kasuga A, Morimoto J, Osaki T, Tahara H, Miyazaki T, Tashiro F, Yamato E, Miyazaki J-i et al (2003) Systemic Administration of IL-18 Promotes Diabetes Development in Young Nonobese Diabetic Mice. J Immunol 171:5865","journal-title":"J Immunol"},{"key":"28037_CR58","unstructured":"Organization WH (2021) Ageing and health. Book Ageing and health, City"},{"key":"28037_CR59","doi-asserted-by":"crossref","unstructured":"Renzetti S, Curtin P, Just A, Gennings CJRpv (2016) Gwqs: Generalized weighted quantile sum regression. 1","DOI":"10.1289\/isee.2016.3985"},{"key":"28037_CR60","first-page":"188","volume":"42","author":"SY Rhee","year":"2018","unstructured":"Rhee SY, Kim YS (2018) The Role of Advanced Glycation End Products in Diabetic Vascular Complications. dmj 42:188\u2013195","journal-title":"dmj"},{"key":"28037_CR61","doi-asserted-by":"crossref","first-page":"3944","DOI":"10.3390\/ijerph120403944","volume":"12","author":"I Rotter","year":"2015","unstructured":"Rotter I, Kosik-Bogacka D, Do\u0142\u0119gowska B, Safranow K, Lubkowska A, Laszczy\u0144ska M (2015) Relationship between the concentrations of heavy metals and bioelements in aging men with metabolic syndrome. Int J Environ Res Public Health 12:3944\u20133961","journal-title":"Int J Environ Res Public Health"},{"key":"28037_CR62","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/jat.3381","volume":"37","author":"L Schumacher","year":"2017","unstructured":"Schumacher L, Abbott LC (2017) Effects of methyl mercury exposure on pancreatic beta cell development and function. J Appl Toxicol 37:4\u201312","journal-title":"J Appl Toxicol"},{"key":"28037_CR63","doi-asserted-by":"crossref","first-page":"40050","DOI":"10.1074\/jbc.M110.154955","volume":"285","author":"SA Soleimanpour","year":"2010","unstructured":"Soleimanpour SA, Crutchlow MF, Ferrari AM, Raum JC, Groff DN, Rankin MM, Liu C, De Le\u00f3n DD, Naji A, Kushner JA et al (2010) Calcineurin signaling regulates human islet {beta}-cell survival. J Biol Chem 285:40050\u201340059","journal-title":"J Biol Chem"},{"key":"28037_CR64","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.7150\/ijms.62843","volume":"18","author":"T Su","year":"2021","unstructured":"Su T, Hou J, Liu T, Dai P, Qin L, Ding L, Hu Y, Guo X (2021) MiR-34a-5p and miR-452-5p: The Novel Regulators of Pancreatic Endocrine Dysfunction in Diabetic Zucker Rats? Int J Med Sci 18:3171\u20133181","journal-title":"Int J Med Sci"},{"key":"28037_CR65","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.scitotenv.2017.05.224","volume":"601","author":"AA Tinkov","year":"2017","unstructured":"Tinkov AA, Filippini T, Ajsuvakova OP, Aaseth J, Gluhcheva YG, Ivanova JM, Bj\u00f8rklund G, Skalnaya MG, Gatiatulina ER, Popova EV (2017a) The role of cadmium in obesity and diabetes. Sci Total Environ 601:741\u2013755","journal-title":"Sci Total Environ"},{"key":"28037_CR66","doi-asserted-by":"crossref","unstructured":"Tinkov AA, Filippini T, Ajsuvakova OP, Aaseth J, Gluhcheva YG, Ivanova JM, Bj\u00f8rklund G, Skalnaya MG, Gatiatulina ER, Popova EVJSoTTE (2017b) The role of cadmium in obesity and diabetes. 601: 741-55","DOI":"10.1016\/j.scitotenv.2017.05.224"},{"key":"28037_CR67","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.envint.2019.02.038","volume":"126","author":"T-L Tsai","year":"2019","unstructured":"Tsai T-L, Kuo C-C, Pan W-H, Wu T-N, Lin P, Wang S-L (2019) Type 2 diabetes occurrence and mercury exposure \u2013 From the National Nutrition and Health Survey in Taiwan. Environ Int 126:260\u2013267","journal-title":"Environ Int"},{"key":"28037_CR68","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jtemb.2016.10.007","volume":"39","author":"JB Tyrrell","year":"2017","unstructured":"Tyrrell JB, Hafida S, Stemmer P, Adhami A, Leff T (2017) Lead (Pb) exposure promotes diabetes in obese rodents. J Trace Elem Med Biol 39:221\u2013226","journal-title":"J Trace Elem Med Biol"},{"key":"28037_CR69","first-page":"4229","volume":"19","author":"T Wang","year":"2019","unstructured":"Wang T, Zhu H, Yang S, Fei X (2019) Let-7a-5p may participate in the pathogenesis of diabetic nephropathy through targeting HMGA2. Mol Med Rep 19:4229\u20134237","journal-title":"Mol Med Rep"},{"key":"28037_CR70","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.envint.2018.09.035","volume":"121","author":"X Wang","year":"2018","unstructured":"Wang X, Mukherjee B, Park SK (2018) Associations of cumulative exposure to heavy metal mixtures with obesity and its comorbidities among U.S. adults in NHANES 2003-2014. Environ Int 121:683\u2013694","journal-title":"Environ Int"},{"key":"28037_CR71","unstructured":"Welfare KMoHa (2021) Korea National Health & Nutrition Examination Survey. Book Korea National Health & Nutrition Examination Survey, City"},{"key":"28037_CR72","unstructured":"WHO (2021) Obesity. Available at: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/obesity-and-overweight. Accessed 1 Aug 2022"},{"key":"28037_CR73","doi-asserted-by":"crossref","first-page":"113129","DOI":"10.18632\/oncotarget.21991","volume":"8","author":"M Wu","year":"2017","unstructured":"Wu M, Song J, Zhu C, Wang Y, Yin X, Huang G, Zhao K, Zhu J, Duan Z, Su L (2017) Association between cadmium exposure and diabetes mellitus risk: a prisma-compliant systematic review and meta-analysis. Oncotarget 8:113129\u2013113141","journal-title":"Oncotarget"},{"key":"28037_CR74","doi-asserted-by":"crossref","unstructured":"Yun S, Nguyen HD, Park JS, Oh C, Kim MS (2021) The association between the metabolic syndrome and iron status in pre- and postmenopausal women: Korean National Health and Nutrition Examination Survey (KNHANES) in 2012. Br J Nutr:1\u201311","DOI":"10.1017\/S0007114521001331"},{"key":"28037_CR75","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1530\/EC-17-0273","volume":"7","author":"E Zaharieva","year":"2018","unstructured":"Zaharieva E, Kamenov Z, Velikova T, Tsakova A, El-Darawish Y, Okamura H (2018) Interleukin-18 serum level is elevated in type 2 diabetes and latent autoimmune diabetes. Endocr Connect 7:179\u2013185","journal-title":"Endocr Connect"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-023-28037-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11356-023-28037-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-023-28037-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,15]],"date-time":"2023-07-15T10:32:25Z","timestamp":1689417145000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11356-023-28037-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,16]]},"references-count":75,"journal-issue":{"issue":"34","published-online":{"date-parts":[[2023,7]]}},"alternative-id":["28037"],"URL":"https:\/\/doi.org\/10.1007\/s11356-023-28037-3","relation":{},"ISSN":["1614-7499"],"issn-type":[{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,16]]},"assertion":[{"value":"26 December 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The KNHANES investigation commission accepted this study (IRB Approval numbers: 2009-01CON-03-2C, 2010-02CON-21-C, 2011-02CON-06-C, 2012-01EXP-01-2C, 2013-07CON-03-4C, 2013-12EXP-03-5C). KNHANES was excluded from assessment on research ethics under the Bioethics and Safety Act from 2016 to 2017.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"All KNHANES participants submitted written informed permission prior to the investigations, which were carried out by the Korea Centers for Disease Control and Prevention's Health and Nutrition Examination Department.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Publish"}},{"value":"The authors have no conflict of interest to declare.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}