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The aim of this study is to optimize the degradation of two pharmaceutical pollutants of emerging concern: amoxicillin and acetaminophen in aqueous solution at laboratory and pilot scale, by solar photo-Fenton process carried out at neutral pH using ethylenediamine-N,N\u2032-disuccinic acid (EDDS) as a complexing agent to maintain iron in solution. The initial concentration of each compound was set at 1 mg\/L dissolved in a simulated effluent from a municipal wastewater treatment plant (MWTP). A factorial experimental design and its surface response analysis were used to optimize the operating parameters to achieve the highest initial degradation rate of each target. The evolution of the degradation process was measured by ultra-performance liquid chromatography (UPLC\/UV), obtaining elimination rates above 90% for both contaminants. Statistical study showed the optimum concentrations of Fe(III) at 3 mg\/L at an Fe-EDDS ratio of 1:2 and 2.75 mg\/L H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    for the almost complete removal of the target compounds by solar photo-Fenton process. Validation of the experimental design was successfully carried out with actual MWTP effluent spiked with 100 \u03bcg\/L of amoxicillin and acetaminophen, each\u00a0at pilot plant scale.\n                  <\/jats:p>","DOI":"10.1007\/s11356-023-28988-7","type":"journal-article","created":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T00:01:50Z","timestamp":1691712110000},"page":"96208-96218","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Solar photo-Fenton optimization at neutral pH for microcontaminant removal at pilot plant scale"],"prefix":"10.1007","volume":"30","author":[{"given":"Mercedes","family":"Hinojosa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9893-6207","authenticated-orcid":false,"given":"Isabel","family":"Oller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"Quiroga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sixto","family":"Malato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"Egea-Corbacho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asunci\u00f3n","family":"Acevedo-Merino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,8,11]]},"reference":[{"key":"28988_CR1","doi-asserted-by":"publisher","first-page":"1878","DOI":"10.1080\/19443994.2013.794015","volume":"52","author":"AC Affam","year":"2014","unstructured":"Affam AC, Chaudhuri M (2014) Optimization of Fenton treatment of amoxicillin and cloxacillin antibiotic aqueous solution. 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