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However, the dysgenic influence of air pollutants on the antiphospholipid syndrome (APS) in mothers and their pregnancy outcomes remains unclear. In the current study, 371 mother-infant pairs (189 healthy: 182 APS) from Nanjing Maternal and Child Health Hospital as well as air pollutants concentration from their living environment were used to investigate correlations between air pollution with maternal blood indicators and fetal birth weight in the groups of APS and healthy mothers. Generalized linear model was used to evaluate the contributions of air pollutant exposure during pregnancy to the blood indicators variation. The relationships between birth weight with specific air pollutant and blood index were analyzed using ridge regression. Results showed that APS fetal birth weight was significantly impacted by air pollutant exposure during pregnancy, in particular, the birth weight decreased significantly along with increasing fine particulate matter 2.5 (PM<jats:sub>2.5<\/jats:sub>) and fine particulate matter 10 (PM<jats:sub>10<\/jats:sub>) exposure concentrations throughout pregnancy. In contrast, birth weight increased significantly with sulfur dioxide (SO<jats:sub>2<\/jats:sub>) exposure. In addition, APS-related blood indicators comprised of platelet distribution width (PDW), total bilirubin (TBIL), mean platelet volume (MPV), platelet-larger cell ratio (P_LCR), homocysteine (HCY), alkaline phosphatase (ALP), direct bilirubin (DBIL), basophilic granulocyte (BAS), platelet thrombocytocrit (PCT), preprandial glucose levels (OGTT0), monocytes (MON), and monocytes ratio (MON_ratio) were also strongly related with prenatal exposure to PM<jats:sub>2.5<\/jats:sub> and PM<jats:sub>10<\/jats:sub>, in which PDW levels showed most strongly negative impaction on fetal birth weight. Together, we showed that prenatal exposure to air pollutant (PM<jats:sub>2.5<\/jats:sub> and PM<jats:sub>10<\/jats:sub>) may exacerbate the poor birth outcomes of low birth weight by impacting APS maternal blood indicators especially for PDW.<\/jats:p>","DOI":"10.1007\/s11356-023-29937-0","type":"journal-article","created":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T06:01:56Z","timestamp":1698818516000},"page":"116266-116278","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between ambient air pollution exposure in pregnant women with antiphospholipid syndrome in Nanjing, China"],"prefix":"10.1007","volume":"30","author":[{"given":"Bimei","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2212-8438","authenticated-orcid":false,"given":"Linjie","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiwen","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yexiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoer","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruizhe","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,11,1]]},"reference":[{"key":"29937_CR1","doi-asserted-by":"publisher","first-page":"106189","DOI":"10.1016\/j.leukres.2019.106189","volume":"84","author":"R Asare","year":"2019","unstructured":"Asare R, Opoku-Okrah C, Danquah KO et al (2019) Expression of platelet parameters and platelet membrane glycoproteins in childhood Burkitt lymphoma. 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