{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T23:54:45Z","timestamp":1779148485990,"version":"3.51.4"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"51","license":[{"start":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T00:00:00Z","timestamp":1696550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T00:00:00Z","timestamp":1696550400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the sponsorship of the National Natural Science Foundation of China","award":["82073566"],"award-info":[{"award-number":["82073566"]}]},{"name":"the Anhui Medical University Clinical Pharmacology and Pharmacology Co-construction Project","award":["2020"],"award-info":[{"award-number":["2020"]}]},{"name":"Anhui public health clinical center, the first affiliated hospital of anhui medical university north area scientific research cultivation fund project","award":["2023YKJ11"],"award-info":[{"award-number":["2023YKJ11"]}]},{"name":"Anhui public health clinical center, the first affiliated hospital of anhui medical university north area scientific research cultivation fund project","award":["2023YKJ06"],"award-info":[{"award-number":["2023YKJ06"]}]},{"name":"Anhui public health clinical center, the first affiliated hospital of anhui medical university north area scientific research cultivation fund project","award":["2023YKJ14"],"award-info":[{"award-number":["2023YKJ14"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"DOI":"10.1007\/s11356-023-30149-9","type":"journal-article","created":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T01:05:50Z","timestamp":1696554350000},"page":"110956-110969","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Obeticholic acid alleviates intrauterine growth restriction induced by di-ethyl-hexyl phthalate in pregnant female mice by improving bile acid disorder"],"prefix":"10.1007","volume":"30","author":[{"given":"Fan","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingchao","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianqian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,10,6]]},"reference":[{"key":"30149_CR1","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1080\/14656566.2016.1218471","volume":"17","author":"AH Ali","year":"2016","unstructured":"Ali AH, Lindor KD (2016) Obeticholic acid for the treatment of primary biliary cholangitis. Expert Opin Pharmacother 17:1809\u20131815. https:\/\/doi.org\/10.1080\/14656566.2016.1218471","journal-title":"Expert Opin Pharmacother"},{"key":"30149_CR2","doi-asserted-by":"publisher","first-page":"e228213","DOI":"10.1371\/journal.pone.0228213","volume":"15","author":"C Arthuis","year":"2020","unstructured":"Arthuis C, Diguisto C, Lorphelin H et al (2020) Perinatal outcomes of intrahepatic cholestasis during pregnancy: an 8-year case-control study. PLoS One 15:e228213. https:\/\/doi.org\/10.1371\/journal.pone.0228213","journal-title":"PLoS One"},{"key":"30149_CR3","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1177\/07482337221108578","volume":"38","author":"S Batool","year":"2022","unstructured":"Batool S, Batool S, Shameem S, Batool T, Batool S (2022) Effects of dibutyl phthalate and di(2-ethylhexyl) phthalate on hepatic structure and function of adult male mice. Toxicol Ind Health 38:470\u2013480. https:\/\/doi.org\/10.1177\/07482337221108578","journal-title":"Toxicol Ind Health"},{"key":"30149_CR4","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/S1665-2681(19)32188-X","volume":"1","author":"D Brites","year":"2002","unstructured":"Brites D (2002) Intrahepatic cholestasis of pregnancy: changes in maternal-fetal bile acid balance and improvement by ursodeoxycholic acid. Ann Hepatol 1:20\u201328","journal-title":"Ann Hepatol"},{"key":"30149_CR5","doi-asserted-by":"publisher","first-page":"7419249","DOI":"10.1155\/2019\/7419249","volume":"15","author":"W Chen","year":"2019","unstructured":"Chen W, Gao XX, Ma L et al (2019) Obeticholic Acid Protects against Gestational Cholestasis-Induced Fetal Intrauterine Growth Restriction in Mice. Oxid Med Cell Longev 15:7419249. https:\/\/doi.org\/10.1155\/2019\/7419249","journal-title":"Oxid Med Cell Longev"},{"issue":"7","key":"30149_CR6","doi-asserted-by":"publisher","first-page":"2514","DOI":"10.1128\/aem.61.7.2514-2520.1995","volume":"61","author":"JP Coleman","year":"1995","unstructured":"Coleman JP, Hudson LL (1995) Cloning and characterization of a conjugated bile acid hydrolase gene from Clostridium perfringens. Appl Environ Microbiol 61(7):2514\u20132520. https:\/\/doi.org\/10.1128\/aem.61.7.2514-2520.1995","journal-title":"Appl Environ Microbiol"},{"key":"30149_CR7","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1053\/gast.2001.25503","volume":"121","author":"LA Denson","year":"2001","unstructured":"Denson LA, Sturm E, Echevarria W et al (2001) The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp. Gastroenterology 121:140\u2013147. https:\/\/doi.org\/10.1053\/gast.2001.25503","journal-title":"Gastroenterology"},{"key":"30149_CR8","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/s0021-9673(02)01736-3","volume":"983","author":"AO Earls","year":"2003","unstructured":"Earls AO, Axford IP, Braybrook JH (2003) Gas chromatography-mass spectrometry determination of the migration of phthalate plasticisers from polyvinyl chloride toys and childcare articles. J Chromatogr a 983:237\u2013246. https:\/\/doi.org\/10.1016\/s0021-9673(02)01736-3","journal-title":"J Chromatogr a"},{"key":"30149_CR9","doi-asserted-by":"publisher","unstructured":"Erythropel HC, Maric M, Nicell JA, Leask RL, Yargeau V (2014) Leaching of the plasticizer di(2-ethylhexyl)phthalate (DEHP) from plastic containers and the question of human exposure. Appl Microbiol Biotechnol 98:9967\u20139981. https:\/\/doi.org\/10.1007\/s00253-014-6183-8","DOI":"10.1007\/s00253-014-6183-8"},{"key":"30149_CR10","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1124\/jpet.104.079665","volume":"313","author":"S Fiorucci","year":"2005","unstructured":"Fiorucci S, Clerici C, Antonelli E et al (2005) Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid x receptor ligand, in estrogen-induced cholestasis. J Pharmacol Exp Ther 313:604\u2013612. https:\/\/doi.org\/10.1124\/jpet.104.079665","journal-title":"J Pharmacol Exp Ther"},{"key":"30149_CR11","doi-asserted-by":"publisher","first-page":"e28","DOI":"10.1097\/MPG.0000000000001813","volume":"66","author":"H Gaitantzi","year":"2018","unstructured":"Gaitantzi H, Hakenberg P, Theobald J et al (2018) Di (2-ethylhexyl) phthalate and its role in developing cholestasis: an in vitro study on different liver cell types. J Pediatr Gastroenterol Nutr 66:e28\u2013e35. https:\/\/doi.org\/10.1097\/MPG.0000000000001813","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"30149_CR12","doi-asserted-by":"publisher","first-page":"119492","DOI":"10.1016\/j.saa.2021.119492","volume":"252","author":"JJ Gao","year":"2021","unstructured":"Gao JJ, Lang XX, Yu QQ, Li HY, Wang HJ, Wang MQ (2021) Amphiphilic bodipy-based nanoparticles as \u201clight-up\u201d fluorescent probe for paes detection by an aggregation\/disaggregation approach. Spectrochim Acta A Mol Biomol Spectrosc 252:119492. https:\/\/doi.org\/10.1016\/j.saa.2021.119492","journal-title":"Spectrochim Acta A Mol Biomol Spectrosc"},{"key":"30149_CR13","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1053\/gast.1996.v110.pm8536857","volume":"110","author":"C Gartung","year":"1996","unstructured":"Gartung C, Ananthanarayanan M, Rahman MA et al (1996) Down-regulation of expression and function of the rat liver na+\/bile acid cotransporter in extrahepatic cholestasis. Gastroenterology 110:199\u2013209. https:\/\/doi.org\/10.1053\/gast.1996.v110.pm8536857","journal-title":"Gastroenterology"},{"key":"30149_CR14","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1002\/hep.20336","volume":"40","author":"A Glantz","year":"2004","unstructured":"Glantz A, Marschall HU, Mattsson LA (2004) Intrahepatic cholestasis of pregnancy: relationships between bile acid levels and fetal complication rates. Hepatology 40:467\u2013474. https:\/\/doi.org\/10.1002\/hep.20336","journal-title":"Hepatology"},{"key":"30149_CR15","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1172\/JCI117091","volume":"93","author":"B Hagenbuch","year":"1994","unstructured":"Hagenbuch B, Meier PJ (1994) Molecular cloning, chromosomal localization, and functional characterization of a human liver na+\/bile acid cotransporter. J Clin Invest 93:1326\u20131331. https:\/\/doi.org\/10.1172\/JCI117091","journal-title":"J Clin Invest"},{"key":"30149_CR16","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1053\/j.gastro.2014.12.005","volume":"148","author":"GM Hirschfield","year":"2015","unstructured":"Hirschfield GM, Mason A, Luketic V et al (2015) Efficacy of obeticholic acid in patients with primary biliary cirrhosis and inadequate response to ursodeoxycholic acid. Gastroenterology 148:751\u2013761. https:\/\/doi.org\/10.1053\/j.gastro.2014.12.005","journal-title":"Gastroenterology"},{"key":"30149_CR17","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.chemosphere.2008.06.019","volume":"73","author":"PC Huang","year":"2008","unstructured":"Huang PC, Tien CJ, Sun YM, Hsieh CY, Lee CC (2008) Occurrence of phthalates in sediment and biota: relationship to aquatic factors and the biota-sediment accumulation factor. Chemosphere 73:539\u2013544. https:\/\/doi.org\/10.1016\/j.chemosphere.2008.06.019","journal-title":"Chemosphere"},{"key":"30149_CR18","doi-asserted-by":"publisher","first-page":"113119","DOI":"10.1016\/j.fct.2022.113119","volume":"165","author":"YQ Huang","year":"2022","unstructured":"Huang YQ, Tang YX, Qiu BH, Talukder M, Li XN, Li JL (2022) Di-2-ethylhexyl phthalate (dehp) induced lipid metabolism disorder in liver via activating the lxr\/srebp-1c\/pparalpha\/gamma and nf-kappab signaling pathway. Food Chem Toxicol 165:113119. https:\/\/doi.org\/10.1016\/j.fct.2022.113119","journal-title":"Food Chem Toxicol"},{"key":"30149_CR19","doi-asserted-by":"publisher","unstructured":"Huang L, Zhu X, Zhou S et al (2021) Phthalic acid esters: natural sources and biological activities. Toxins (Basel) 13. https:\/\/doi.org\/10.3390\/toxins13070495","DOI":"10.3390\/toxins13070495"},{"key":"30149_CR20","doi-asserted-by":"publisher","first-page":"19081","DOI":"10.1074\/jbc.M600116200","volume":"281","author":"D Jung","year":"2006","unstructured":"Jung D, Mangelsdorf DJ, Meyer UA (2006) Pregnane x receptor is a target of farnesoid x receptor. J Biol Chem 281:19081\u201319091. https:\/\/doi.org\/10.1074\/jbc.M600116200","journal-title":"J Biol Chem"},{"key":"30149_CR21","doi-asserted-by":"publisher","unstructured":"Kaestner F, Seiler F, Rapp D et al (2020) Exposure of patients to di(2-ethylhexy)phthalate (DEHP) and its metabolite mehp during extracorporeal membrane oxygenation (ecmo) therapy. Plos One 15:e224931. https:\/\/doi.org\/10.1371\/journal.pone.0224931","DOI":"10.1371\/journal.pone.0224931"},{"key":"30149_CR22","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1002\/hep.29199","volume":"66","author":"KH Kim","year":"2017","unstructured":"Kim KH, Choi S, Zhou Y et al (2017) Hepatic fxr\/shp axis modulates systemic glucose and fatty acid homeostasis in aged mice. Hepatology 66:498\u2013509. https:\/\/doi.org\/10.1002\/hep.29199","journal-title":"Hepatology"},{"key":"30149_CR23","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.jhep.2020.07.028","volume":"74","author":"K Kjaergaard","year":"2021","unstructured":"Kjaergaard K, Frisch K, Sorensen M et al (2021) Obeticholic acid improves hepatic bile acid excretion in patients with primary biliary cholangitis. J Hepatol 74:58\u201365. https:\/\/doi.org\/10.1016\/j.jhep.2020.07.028","journal-title":"J Hepatol"},{"key":"30149_CR24","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s10555-007-9039-1","volume":"26","author":"GD Kruh","year":"2007","unstructured":"Kruh GD, Belinsky MG, Gallo JM, Lee K (2007) Physiological and pharmacological functions of mrp2, mrp3 and mrp4 as determined from recent studies on gene-disrupted mice. Cancer Metastasis Rev 26:5\u201314. https:\/\/doi.org\/10.1007\/s10555-007-9039-1","journal-title":"Cancer Metastasis Rev"},{"issue":"4","key":"30149_CR25","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1124\/pr.113.008201","volume":"66","author":"TG Li","year":"2014","unstructured":"Li TG, Chiang JY (2014) Bile acid signaling in metabolic disease and drug therapy. Pharmacol Rev 66(4):948\u2013983. https:\/\/doi.org\/10.1124\/pr.113.008201","journal-title":"Pharmacol Rev"},{"key":"30149_CR26","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.21037\/atm-20-4879","volume":"8","author":"C Liu","year":"2020","unstructured":"Liu C, Gao J, Liu J et al (2020) Intrahepatic cholestasis of pregnancy is associated with an increased risk of gestational diabetes and preeclampsia. Ann Transl Med 8:1574. https:\/\/doi.org\/10.21037\/atm-20-4879","journal-title":"Ann Transl Med"},{"key":"30149_CR27","doi-asserted-by":"publisher","first-page":"23501","DOI":"10.1007\/s11356-020-11990-8","volume":"28","author":"RJ Liu","year":"2021","unstructured":"Liu RJ, He YJ, Liu H, Zheng DD, Huang SW, Liu CH (2021) Protective effect of lycium barbarum polysaccharide on di-(2-ethylhexyl) phthalate-induced toxicity in rat liver. Environ Sci Pollut Res Int 28:23501\u201323509. https:\/\/doi.org\/10.1007\/s11356-020-11990-8","journal-title":"Environ Sci Pollut Res Int"},{"key":"30149_CR28","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1126\/science.284.5418.1362","volume":"284","author":"M Makishima","year":"1999","unstructured":"Makishima M, Okamoto AY, Repa JJ et al (1999) Identification of a nuclear receptor for bile acids. Science 284:1362\u20131365. https:\/\/doi.org\/10.1126\/science.284.5418.1362","journal-title":"Science"},{"key":"30149_CR29","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.reprotox.2010.03.002","volume":"29","author":"F Maranghi","year":"2010","unstructured":"Maranghi F, Lorenzetti S, Tassinari R et al (2010) In utero exposure to di-(2-ethylhexyl) phthalate affects liver morphology and metabolism in post-natal cd-1 mice. Reprod Toxicol 29:427\u2013432. https:\/\/doi.org\/10.1016\/j.reprotox.2010.03.002","journal-title":"Reprod Toxicol"},{"key":"30149_CR30","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1111\/j.1478-3231.2008.01680.x","volume":"28","author":"JJ Marin","year":"2008","unstructured":"Marin JJ, Macias RI, Briz O et al (2008) Molecular bases of the fetal liver-placenta-maternal liver excretory pathway for cholephilic compounds. Liver Int 28:435\u2013454. https:\/\/doi.org\/10.1111\/j.1478-3231.2008.01680.x","journal-title":"Liver Int"},{"key":"30149_CR31","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1016\/S0140-6736(19)31607-1","volume":"394","author":"HU Marschall","year":"2019","unstructured":"Marschall HU (2019) Ursodeoxycholic acid for intrahepatic cholestasis in pregnancy. Lancet 394:810\u2013812. https:\/\/doi.org\/10.1016\/S0140-6736(19)31607-1","journal-title":"Lancet"},{"key":"30149_CR32","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1016\/S0140-6736(14)61933-4","volume":"385","author":"BA Neuschwander-Tetri","year":"2015","unstructured":"Neuschwander-Tetri BA, Loomba R, Sanyal AJ et al (2015) Farnesoid x nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (flint): a multicentre, randomised, placebo-controlled trial. Lancet 385:956\u2013965. https:\/\/doi.org\/10.1016\/S0140-6736(14)61933-4","journal-title":"Lancet"},{"key":"30149_CR33","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1007\/s00424-006-0109-y","volume":"453","author":"AT Nies","year":"2007","unstructured":"Nies AT, Keppler D (2007) The apical conjugate efflux pump abcc2 (mrp2). Pflugers Arch 453:643\u2013659. https:\/\/doi.org\/10.1007\/s00424-006-0109-y","journal-title":"Pflugers Arch"},{"key":"30149_CR34","doi-asserted-by":"publisher","first-page":"G1","DOI":"10.1152\/ajpgi.00028.2017","volume":"313","author":"V Pataia","year":"2017","unstructured":"Pataia V, Dixon PH, Williamson C (2017) Pregnancy and bile acid disorders. Am J Physiol Gastrointest Liver Physiol 313:G1\u2013G6. https:\/\/doi.org\/10.1152\/ajpgi.00028.2017","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"30149_CR35","doi-asserted-by":"publisher","first-page":"G197","DOI":"10.1152\/ajpgi.00126.2020","volume":"319","author":"V Pataia","year":"2020","unstructured":"Pataia V, Mcilvride S, Papacleovoulou G et al (2020) Obeticholic acid improves fetal bile acid profile in a mouse model of gestational hypercholanemia. Am J Physiol Gastrointest Liver Physiol 319:G197\u2013G211. https:\/\/doi.org\/10.1152\/ajpgi.00126.2020","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"30149_CR36","doi-asserted-by":"publisher","unstructured":"Piechota J, Jelski W (2020) Intrahepatic cholestasis in pregnancy: review of the literature. J Clin Med 9. https:\/\/doi.org\/10.3390\/jcm9051361","DOI":"10.3390\/jcm9051361"},{"key":"30149_CR37","doi-asserted-by":"publisher","unstructured":"Pournejati R, Gust R, Sagasser J et al (2021) In vitro evaluation of cytotoxic effects of di(2-ethylhexyl)phthalate (DEHP) produced by bacillus velezensis strain rp137 isolated from persian gulf. Toxicol in Vitro 73:105148. https:\/\/doi.org\/10.1016\/j.tiv.2021.105148","DOI":"10.1016\/j.tiv.2021.105148"},{"key":"30149_CR38","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1016\/j.apsb.2019.03.005","volume":"9","author":"X Qin","year":"2019","unstructured":"Qin X, Wang X (2019) Role of vitamin d receptor in the regulation of cyp3a gene expression. Acta Pharm Sin B 9:1087\u20131098. https:\/\/doi.org\/10.1016\/j.apsb.2019.03.005","journal-title":"Acta Pharm Sin B"},{"key":"30149_CR39","doi-asserted-by":"publisher","first-page":"115703","DOI":"10.1016\/j.taap.2021.115703","volume":"429","author":"X Qin","year":"2021","unstructured":"Qin X, Zhang Y, Lu J, Huang S, Liu Z, Wang X (2021) Cyp3a deficiency alters bile acid homeostasis and leads to changes in hepatic susceptibility in rats. Toxicol Appl Pharmacol 429:115703. https:\/\/doi.org\/10.1016\/j.taap.2021.115703","journal-title":"Toxicol Appl Pharmacol"},{"key":"30149_CR40","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1093\/toxsci\/57.1.177","volume":"57","author":"AP Rolo","year":"2000","unstructured":"Rolo AP, Oliveira PJ, Moreno AJ, Palmeira CM (2000) Bile acids affect liver mitochondrial bioenergetics: possible relevance for cholestasis therapy. Toxicol Sci 57:177\u2013185. https:\/\/doi.org\/10.1093\/toxsci\/57.1.177","journal-title":"Toxicol Sci"},{"key":"30149_CR41","doi-asserted-by":"publisher","first-page":"1750368","DOI":"10.1155\/2018\/1750368","volume":"2018","author":"S Rowdhwal","year":"2018","unstructured":"Rowdhwal S, Chen J (2018) Toxic effects of di-2-ethylhexyl phthalate: an overview. Biomed Res Int 2018:1750368. https:\/\/doi.org\/10.1155\/2018\/1750368","journal-title":"Biomed Res Int"},{"key":"30149_CR42","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1136\/gutjnl-2020-323345","volume":"71","author":"A Salhab","year":"2022","unstructured":"Salhab A, Amer J, Lu Y, Safadi R (2022) Sodium(+)\/taurocholate cotransporting polypeptide as target therapy for liver fibrosis. Gut 71:1373\u20131385. https:\/\/doi.org\/10.1136\/gutjnl-2020-323345","journal-title":"Gut"},{"key":"30149_CR43","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.reprotox.2016.12.003","volume":"67","author":"R Shen","year":"2017","unstructured":"Shen R, Zhao LL, Yu Z et al (2017) Maternal di-(2-ethylhexyl) phthalate exposure during pregnancy causes fetal growth restriction in a stage-specific but gender-independent manner. Reprod Toxicol 67:117\u2013124. https:\/\/doi.org\/10.1016\/j.reprotox.2016.12.003","journal-title":"Reprod Toxicol"},{"key":"30149_CR44","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/s0092-8674(00)00062-3","volume":"102","author":"CJ Sinal","year":"2000","unstructured":"Sinal CJ, Tohkin M, Miyata M, Ward JM, Lambert G, Gonzalez FJ (2000) Targeted disruption of the nuclear receptor fxr\/bar impairs bile acid and lipid homeostasis. Cell 102:731\u2013744. https:\/\/doi.org\/10.1016\/s0092-8674(00)00062-3","journal-title":"Cell"},{"key":"30149_CR45","doi-asserted-by":"publisher","first-page":"1926","DOI":"10.1016\/j.bbamem.2013.04.003","volume":"1828","author":"M Singh","year":"2013","unstructured":"Singh M, Singh A, Kundu S, Bansal S, Bajaj A (2013) Deciphering the role of charge, hydration, and hydrophobicity for cytotoxic activities and membrane interactions of bile acid based facial amphiphiles. Biochim Biophys Acta 1828:1926\u20131937. https:\/\/doi.org\/10.1016\/j.bbamem.2013.04.003","journal-title":"Biochim Biophys Acta"},{"key":"30149_CR46","doi-asserted-by":"publisher","first-page":"e2117409","DOI":"10.1001\/jamanetworkopen.2021.17409","volume":"4","author":"F Song","year":"2021","unstructured":"Song F, Chen Y, Chen L, Li H, Cheng X, Wu W (2021) Association of elevated maternal serum total bile acids with low birth weight and intrauterine fetal growth restriction. JAMA Netw Open 4:e2117409. https:\/\/doi.org\/10.1001\/jamanetworkopen.2021.17409","journal-title":"JAMA Netw Open"},{"key":"30149_CR47","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/s41575-020-00404-2","volume":"18","author":"L Sun","year":"2021","unstructured":"Sun L, Cai J, Gonzalez FJ (2021) The role of farnesoid x receptor in metabolic diseases, and gastrointestinal and liver cancer. Nat Rev Gastroenterol Hepatol 18:335\u2013347. https:\/\/doi.org\/10.1038\/s41575-020-00404-2","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"6","key":"30149_CR48","doi-asserted-by":"publisher","first-page":"2502","DOI":"10.1128\/AEM.66.6.2502-2512.2000","volume":"66","author":"H Tanaka","year":"2000","unstructured":"Tanaka H, Hashiba H, Kok J, Mierau I (2000) Bile salt hydrolase of Bifidobacterium longum: biochemical and genetic characterization. Appl Environ Microbiol 66(6):2502\u20132512. https:\/\/doi.org\/10.1128\/AEM.66.6.2502-2512.2000","journal-title":"Appl Environ Microbiol"},{"key":"30149_CR49","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/s1534-5807(02)00187-9","volume":"2","author":"L Wang","year":"2002","unstructured":"Wang L, Lee YK, Bundman D et al (2002) Redundant pathways for negative feedback regulation of bile acid production. Dev Cell 2:721\u2013731. https:\/\/doi.org\/10.1016\/s1534-5807(02)00187-9","journal-title":"Dev Cell"},{"key":"30149_CR50","doi-asserted-by":"publisher","first-page":"11714","DOI":"10.1007\/s11356-020-07675-x","volume":"27","author":"JQ Wang","year":"2020","unstructured":"Wang JQ, Gao H, Sheng J et al (2020) Urinary concentrations of phthalate metabolites during gestation and intrahepatic cholestasis of pregnancy: a population-based birth cohort study. Environ Sci Pollut Res Int 27:11714\u201311723. https:\/\/doi.org\/10.1007\/s11356-020-07675-x","journal-title":"Environ Sci Pollut Res Int"},{"key":"30149_CR51","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1097\/AOG.0000000000000346","volume":"124","author":"C Williamson","year":"2014","unstructured":"Williamson C, Geenes V (2014) Intrahepatic cholestasis of pregnancy. Obstet Gynecol 124:120\u2013133. https:\/\/doi.org\/10.1097\/AOG.0000000000000346","journal-title":"Obstet Gynecol"},{"key":"30149_CR52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.toxlet.2018.05.013","volume":"294","author":"Z Yu","year":"2018","unstructured":"Yu Z, Han Y et al (2018) Gestational di-(2-ethylhexyl) phthalate exposure causes fetal intrauterine growth restriction through disturbing placental thyroid hormone receptor signaling. Toxicol Lett 294:1\u201310. https:\/\/doi.org\/10.1016\/j.toxlet.2018.05.013","journal-title":"Toxicol Lett"},{"key":"30149_CR53","doi-asserted-by":"publisher","first-page":"106608","DOI":"10.1016\/j.envint.2021.106608","volume":"155","author":"L Yu","year":"2021","unstructured":"Yu L, Yang M, Cheng M et al (2021a) Associations between urinary phthalate metabolite concentrations and markers of liver injury in the us adult population. Environ Int 155:106608. https:\/\/doi.org\/10.1016\/j.envint.2021.106608","journal-title":"Environ Int"},{"key":"30149_CR54","doi-asserted-by":"publisher","first-page":"127959","DOI":"10.1016\/j.chemosphere.2020.127959","volume":"263","author":"Z Yu","year":"2021","unstructured":"Yu Z, Shi ZH, Zheng ZY et al (2021b) DEHP induce cholesterol imbalance via disturbing bile acid metabolism by altering the composition of gut microbiota in mouse. Chemosphere 263:127959. https:\/\/doi.org\/10.1016\/j.chemosphere.2020.127959","journal-title":"Chemosphere"},{"key":"30149_CR55","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1111\/bph.13729","volume":"174","author":"H Zeng","year":"2017","unstructured":"Zeng H, Jiang Y, Chen P et al (2017) Schisandrol b protects against cholestatic liver injury through pregnane x receptors. Br J Pharmacol 174:672\u2013688. https:\/\/doi.org\/10.1111\/bph.13729","journal-title":"Br J Pharmacol"},{"key":"30149_CR56","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106442","volume":"83","author":"C Zhang","year":"2020","unstructured":"Zhang C, Gan Y, Lv JW et al (2020) The protective effect of obeticholic acid on lipopolysaccharide-induced disorder of maternal bile acid metabolism in pregnant mice. Int Immunopharmacol 83:106442. https:\/\/doi.org\/10.1016\/j.intimp.2020.106442","journal-title":"Int Immunopharmacol"},{"key":"30149_CR57","doi-asserted-by":"publisher","first-page":"145418","DOI":"10.1016\/j.scitotenv.2021.145418","volume":"771","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Jiao Y, Li Z, Tao Y, Yang Y (2021) Hazards of phthalates (paes) exposure: a review of aquatic animal toxicology studies. Sci Total Environ 771:145418. https:\/\/doi.org\/10.1016\/j.scitotenv.2021.145418","journal-title":"Sci Total Environ"},{"key":"30149_CR58","doi-asserted-by":"publisher","first-page":"1014243","DOI":"10.3389\/fcell.2022.1014243","volume":"10","author":"F Zhang","year":"2022","unstructured":"Zhang F, Zhen HL et al (2022) Di-(2-ethylhexyl) phthalate exposure induces liver injury by promoting ferroptosis via downregulation of GPX4 in pregnant mice. Front Cell Dev Biol 10:1014243. https:\/\/doi.org\/10.3389\/fcell.2022.1014243","journal-title":"Front Cell Dev Biol"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-023-30149-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11356-023-30149-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-023-30149-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,4]],"date-time":"2023-11-04T07:37:21Z","timestamp":1699083441000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11356-023-30149-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,6]]},"references-count":58,"journal-issue":{"issue":"51","published-online":{"date-parts":[[2023,11]]}},"alternative-id":["30149"],"URL":"https:\/\/doi.org\/10.1007\/s11356-023-30149-9","relation":{},"ISSN":["1614-7499"],"issn-type":[{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,6]]},"assertion":[{"value":"30 April 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 October 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The experiment was conducted according to the guidelines of the National Institutes of Health (NIH publication No. 85\u201323, revised in 2011) and approved by the Research Ethics Committee of Anhui Medical University (Approval No.: 20200523).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"None.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}