{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:09:03Z","timestamp":1773360543854,"version":"3.50.1"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"13","license":[{"start":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T00:00:00Z","timestamp":1708041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T00:00:00Z","timestamp":1708041600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Johannes Kepler University Linz"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The uptake, translocation, and metabolization of four widely used drugs, amitriptyline, orphenadrine, lidocaine, and tramadol, were investigated in a laboratory study. Cress\n                    <jats:italic>(Lepidium sativum<\/jats:italic>\n                    L.) and pea (\n                    <jats:italic>Pisum sativum<\/jats:italic>\n                    L.) were employed as model plants. These plants were grown in tap water containing the selected pharmaceuticals at concentrations ranging from 0.010 to 10\u00a0mg L\n                    <jats:sup>\u22121<\/jats:sup>\n                    , whereby the latter concentration was employed for the (tentative) identification of drug-related metabolites formed within the plant. Thereby, mainly phase I metabolites were detected. Time-resolved uptake studies, with sampling after 1, 2, 4, 8, and 16\u00a0days, revealed that all four pharmaceuticals were taken up by the roots and further relocated to plant stem and leaves. Also in these studies, the corresponding phase I metabolites could be detected, and their translocation from root to stem (pea only) and finally leaves could be investigated.\n                  <\/jats:p>","DOI":"10.1007\/s11356-024-32379-x","type":"journal-article","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T06:02:39Z","timestamp":1708063359000},"page":"19649-19657","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Uptake, translocation, and metabolization of amitriptyline, lidocaine, orphenadrine, and tramadol by cress and pea"],"prefix":"10.1007","volume":"31","author":[{"given":"Anna","family":"Detzlhofer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Grechhamer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence","family":"Madikizela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Himmelsbach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franz","family":"Mlynek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Buchberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian W.","family":"Klampfl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,2,16]]},"reference":[{"key":"32379_CR1","doi-asserted-by":"publisher","first-page":"127284","DOI":"10.1016\/j.jhazmat.2021.127284","volume":"424","author":"AS Adeleye","year":"2022","unstructured":"Adeleye AS, Xue J, Zhao Y, Taylor AA, Zenobio JE, Sun Y, Han Z, Salawu OA, Zhu Y (2022) Abundance, fate, and effects of pharmaceuticals and personal care products in aquatic environments. J Hazard Mat 424:127284","journal-title":"J Hazard Mat"},{"key":"32379_CR2","doi-asserted-by":"publisher","first-page":"3883","DOI":"10.1007\/s10311-022-01498-7","volume":"20","author":"U Anand","year":"2022","unstructured":"Anand U, Adelodun B, Cabreros C, Kumar P, Suresh S, Dey A, Ballesteros F Jr, Bontempi E (2022) Occurrence, transformation, bioaccumulation, risk and analysis of pharmaceutical and personal care products from wastewater: a review. Environ Chem Lett 20:3883\u20133904","journal-title":"Environ Chem Lett"},{"key":"32379_CR3","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.tplants.2016.12.010","volume":"22","author":"M Bartrons","year":"2017","unstructured":"Bartrons M, Pe\u00f1uelas J (2017) Pharmaceuticals and personal-care products in plants. Trends Plant Sci 22:194\u2013203","journal-title":"Trends Plant Sci"},{"key":"32379_CR4","doi-asserted-by":"publisher","first-page":"153635","DOI":"10.1016\/j.scitotenv.2022.153635","volume":"823","author":"JP Bavumiragira","year":"2022","unstructured":"Bavumiragira JP, Ge J, Yin H (2022) Fate and transport of pharmaceuticals in water systems: a processes review. Sci Tot Environ 823:153635","journal-title":"Sci Tot Environ"},{"key":"32379_CR5","doi-asserted-by":"crossref","unstructured":"aus der Beek T, Weber FA, Bergmann A, Hickmann S, Ebert I, Hein A, K\u00fcster A (2016) Pharmaceuticals in the environment - global occurrences and perspectives, Environ Toxicol Chem 35:823\u2013835","DOI":"10.1002\/etc.3339"},{"key":"32379_CR6","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1002\/elps.201700438","volume":"39","author":"L Emhofer","year":"2018","unstructured":"Emhofer L, Himmelsbach M, Buchberger W, Klampfl CW (2018) Insights into the uptake, metabolization and translocation of four non-steroidal anti-inflammatory drugs in cress (Lepidium sativum) by HPLC-MS2. Electrophoresis 39:1294\u20131300","journal-title":"Electrophoresis"},{"key":"32379_CR7","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.chroma.2019.01.049","volume":"1592","author":"L Emhofer","year":"2019","unstructured":"Emhofer L, Himmelsbach M, Buchberger W, Klampfl CW (2019) HPLC drift-tube ion-mobility quadrupole time-of-flight \/ mass spectrometry for the identification and characterization of metabolites from three statins (lipid lowering drugs) in the mode plant garden cress (Lepidium sativum). J Chromatogr A 1592:122\u2013132","journal-title":"J Chromatogr A"},{"key":"32379_CR8","doi-asserted-by":"publisher","first-page":"14083","DOI":"10.1021\/acs.est.9b06206","volume":"53","author":"Q Fu","year":"2019","unstructured":"Fu Q, Malchi T, Carter LJ, Li H, Gan J, Chefetz B (2019) Pharmaceutical and personal care products: from wastewater treatment into agro-food systems. Environ Sci Technol 53:14083\u201314090","journal-title":"Environ Sci Technol"},{"issue":"2017","key":"32379_CR9","doi-asserted-by":"publisher","first-page":"6071","DOI":"10.1021\/acs.est.6b06266","volume":"51","author":"Q Fu","year":"2017","unstructured":"Fu Q, Zhang J, Borchardt D, Schlenk D, Gan J (2017) Direct conjugation of emerging contaminants in arabidopsis: indication for an overlooked risk in plants? Environ Sci Technol 51(2017):6071\u20136081","journal-title":"Environ Sci Technol"},{"key":"32379_CR10","doi-asserted-by":"publisher","first-page":"128737","DOI":"10.1016\/j.chemosphere.2020.128737","volume":"269","author":"KM Gani","year":"2021","unstructured":"Gani KM, Hlongwa N, Abunama T, Kumari S, Bux F (2021) Emerging contaminants in South African water environment- a critical review of their occurrence, sources and ecotoxicological risks. Chemosphere 269:128737","journal-title":"Chemosphere"},{"key":"32379_CR11","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/S0378-4274(02)00041-3","volume":"131","author":"T Heberer","year":"2002","unstructured":"Heberer T (2002) Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. Toxicol Lett 131:5\u201317","journal-title":"Toxicol Lett"},{"key":"32379_CR12","first-page":"100172","volume":"8","author":"R Hern\u00e1ndez-Tenorio","year":"2022","unstructured":"Hern\u00e1ndez-Tenorio R, Gonz\u00e1lez-Ju\u00e1rez E, Guzm\u00e1n-Mar JL, Hinojosa-Reyes L, Hern\u00e1ndez-Ram\u00edrez A (2022) Review of occurrence of pharmaceuticals worldwide for estimating concentration ranges in aquatic environments at the end of the last decade. J Hazard Mat Adv 8:100172","journal-title":"J Hazard Mat Adv"},{"key":"32379_CR13","doi-asserted-by":"publisher","unstructured":"Keerthanan S, Jayasinghe C, Kumar Biswas J, Vithanage M (2021) Pharmaceutical and personal care products (PPCPs) in the environment: plant uptake, translocation, bio-accumulation, and human health risks, Crit. Rev Environ Sci Technol.https:\/\/doi.org\/10.1080\/10643389.2020.1753634","DOI":"10.1080\/10643389.2020.1753634"},{"key":"32379_CR14","first-page":"13","volume":"111","author":"CW Klampfl","year":"2019","unstructured":"Klampfl CW (2019) Metabolization of pharmaceuticals by plants after uptake from water and soil: a review, Trends Anal. Chem 111:13\u201326","journal-title":"Chem"},{"key":"32379_CR15","doi-asserted-by":"publisher","unstructured":"Klampfl CW, Buchberger W, Mlynek F, Himmelsbach M (2021) Metabolization of pharmaceuticals by plants after uptake from water; in S. P\u00e9rez Solsona, N. Montemurro, S. Chiron, D. Barcel\u00f3 (eds.), Interaction and fate of pharmaceuticals in soil-crop systems: the impact of reclaimed wastewater, Hdb Env Chem, DOI https:\/\/doi.org\/10.1007\/698_2020_629 Springer-Nature","DOI":"10.1007\/698_2020_629"},{"key":"32379_CR16","doi-asserted-by":"publisher","first-page":"9876","DOI":"10.1007\/s11356-019-04333-9","volume":"26","author":"R Kode\u0161ov\u00e1","year":"2019","unstructured":"Kode\u0161ov\u00e1 R, KlementA GO, F\u00e9r M, Nikodem A, Ko\u010d\u00e1rek M, Grabic R (2019) Root uptake of atenolol, sulfamethoxazole and carbamazepine, and their transformation in three soils and four plants. Environ Sci Poll Res 26:9876\u20139891","journal-title":"Environ Sci Poll Res"},{"key":"32379_CR17","doi-asserted-by":"publisher","first-page":"50790","DOI":"10.1007\/s11356-021-14289-4","volume":"28","author":"T Lang","year":"2021","unstructured":"Lang T, Himmelsbach M, Mlynek F, Buchberger W, Klampfl CW (2021) Uptake and bio-transformation of telmisartan by cress (Lepidium sativum) from sewage treatment plant effluents using high-performance liquid chromatography\/drift-tube ion-mobility quadrupole time-of-flight mass spectrometry. Environ Sci Pollut Res 28:50790\u201350798","journal-title":"Environ Sci Pollut Res"},{"key":"32379_CR18","doi-asserted-by":"publisher","first-page":"130688","DOI":"10.1016\/j.chemosphere.2021.130688","volume":"280","author":"LM Madikizela","year":"2021","unstructured":"Madikizela LM, Ncube S (2021) Occurrence and ecotoxicological risk assessment of non-steroidal anti-inflammatory drugs in South African aquatic environment: what is known and the missing information? Chemosphere 280:130688","journal-title":"Chemosphere"},{"key":"32379_CR19","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.scitotenv.2018.04.297","volume":"636","author":"LM Madikizela","year":"2018","unstructured":"Madikizela LM, Ncube S, Chimuka L (2018) Uptake of pharmaceuticals by plants grown under hydroponic conditions and natural occurring plant species: a review. Sci Total Environ 636:477\u2013486","journal-title":"Sci Total Environ"},{"key":"32379_CR20","doi-asserted-by":"publisher","first-page":"1817","DOI":"10.1007\/s00216-020-02429-7","volume":"412","author":"F Mlynek","year":"2020","unstructured":"Mlynek F, Himmelsbach M, Buchberger W, Klampfl CW (2020) A new analytical workflow using HPLC with drift-tube ion-mobility quadrupole time-of-flight\/mass spectrometry for the detection of drug-related metabolites in plants. Anal Bioanal Chem 412:1817\u20131824","journal-title":"Anal Bioanal Chem"},{"key":"32379_CR21","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1002\/elps.202000292","volume":"42","author":"F Mlynek","year":"2021","unstructured":"Mlynek F, Himmelsbach M, Buchberger W, Klampfl CW (2021) A fast-screening approach for the tentative identification of drug-related metabolites from three non-steroidal anti-inflammatory drugs in hydroponically grown edible plants by HPLC-drift-tube-ion-mobility quadrupole time-of-flight mass spectrometry. Electrophoresis 42:482\u2013489","journal-title":"Electrophoresis"},{"key":"32379_CR22","first-page":"173","volume":"94","author":"Y Pico","year":"2017","unstructured":"Pico Y, Alfarham A, Barcelo D (2017) Analysis of emerging contaminants and nanomaterials in plant materials following uptake from soils, Trends Anal. Chem 94:173\u2013189","journal-title":"Chem"},{"key":"32379_CR23","doi-asserted-by":"publisher","first-page":"149134","DOI":"10.1016\/j.scitotenv.2021.149134","volume":"797","author":"BS Rathi","year":"2021","unstructured":"Rathi BS, Kumar PS, Vo D-VN (2021) Critical review on hazardous pollutants in water environment: occurrence, monitoring, fate, removal technologies and risk assessment. Sci Tot Environ 797:149134","journal-title":"Sci Tot Environ"},{"key":"32379_CR24","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1016\/j.scitotenv.2018.04.375","volume":"636","author":"VL Reddy Pullagurala","year":"2018","unstructured":"Reddy Pullagurala VL, Rawat S, Adisa IO, Hernandez-Viezcas JA, Peralta-Videa JR, Gardea-Torresdey JL (2018) Plant uptake and translocation of contaminants of emerging concern in soil. Sci Total Environ 636:1585\u20131596","journal-title":"Sci Total Environ"},{"key":"32379_CR25","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1002\/elps.201700482","volume":"39","author":"B Reichl","year":"2018","unstructured":"Reichl B, Himmelsbach M, Emhofer L, Klampfl CW, Buchberger W (2018) Uptake and metabolism of the antidepressants sertraline, clomipramine, and trazodone in a garden cress (Lepidium sativum) model. Electrophoresis 39:1301\u20131308","journal-title":"Electrophoresis"},{"key":"32379_CR26","doi-asserted-by":"publisher","first-page":"6100","DOI":"10.1021\/acs.est.6b06485","volume":"51","author":"C Riemenschneider","year":"2017","unstructured":"Riemenschneider C, Seiwert B, Moeder M, Schwarz D, Reemtsma T (2017) Extensive transformation of the pharmaceutical carbamazepine following uptake into intact tomato plants. Environ Sci Technol 51:6100\u20136109","journal-title":"Environ Sci Technol"},{"key":"32379_CR27","doi-asserted-by":"publisher","first-page":"118049","DOI":"10.1016\/j.envpol.2021.118049","volume":"290","author":"C Rodrigues dos Santos","year":"2022","unstructured":"Rodrigues dos Santos C, Santos Arcanjo G, de Souza Santos LV, Koch K, Santos Amaral MC (2022) Aquatic concentration and risk assessment of pharmaceutically active compounds in the environment. Environ Poll 290:118049","journal-title":"Environ Poll"},{"key":"32379_CR28","doi-asserted-by":"publisher","unstructured":"Sauvetre A, Eichhorn P, Perez S (2021) Metabolism of pharmaceuticals in plants and their associated microbiota; in S. P\u00e9rez Solsona, N. Montemurro, S. Chiron, D. Barcel\u00f3 (eds.), Interaction and fate of pharmaceuticals in soil-crop systems: the impact of reclaimed wastewater, Hdb Env Chem, DOI https:\/\/doi.org\/10.1007\/698_2020_629 Springer-Nature","DOI":"10.1007\/698_2020_629"},{"key":"32379_CR29","doi-asserted-by":"publisher","first-page":"2097","DOI":"10.1021\/es5002105","volume":"48","author":"EL Schymanski","year":"2014","unstructured":"Schymanski EL, Jeon J, Gulde R, Fenner K, Ruff M, Singer HP, Hollender J (2014) Identifying small molecules via high resolution mass spectrometry: communicating confidence. Environ Sci Technol 48:2097\u20132098","journal-title":"Environ Sci Technol"},{"key":"32379_CR30","doi-asserted-by":"crossref","unstructured":"Wang K, Zhuang T, Su Z, Chi M, Wang H (2021) Antibiotic residues in wastewaters from sewage treatment plants and pharmaceutical industries: occurrence, removal and environmental impacts. Sci Tot Environ 788:147811","DOI":"10.1016\/j.scitotenv.2021.147811"},{"key":"32379_CR31","doi-asserted-by":"publisher","first-page":"11286","DOI":"10.1021\/es502868k","volume":"48","author":"X Wu","year":"2014","unstructured":"Wu X, Conkle JL, Ernst F, Gan J (2014) Treated wastewater irrigation: uptake of pharmaceutical and personal care products by common vegetables under field conditions. Environ Sci Technol 48:11286\u201311293","journal-title":"Environ Sci Technol"},{"key":"32379_CR32","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.envpol.2015.12.050","volume":"211","author":"X Wu","year":"2016","unstructured":"Wu X, Fu Q, Gan J (2016) Metabolism of pharmaceutical and personal care products by carrot cell cultures. Environ Pollut 211:141\u2013147","journal-title":"Environ Pollut"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-024-32379-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11356-024-32379-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-024-32379-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T05:35:38Z","timestamp":1710394538000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11356-024-32379-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,16]]},"references-count":32,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["32379"],"URL":"https:\/\/doi.org\/10.1007\/s11356-024-32379-x","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-2466773\/v1","asserted-by":"object"}]},"ISSN":["1614-7499"],"issn-type":[{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,16]]},"assertion":[{"value":"17 January 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}