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Studies on the effects of pesticides on bees have reported effects on both metabolic and neurological levels under chronic exposure. In this study, variations in the differential expression of head and thorax\u2013abdomen proteins in Africanized <jats:italic>A. mellifera<\/jats:italic> bees treated acutely with sublethal doses of glyphosate and imidacloprid were studied using a proteomic approach. A total of 92 proteins were detected, 49 of which were differentially expressed compared to those in the control group (47 downregulated and 2 upregulated). Protein interaction networks with differential protein expression ratios suggested that acute exposure of <jats:italic>A. mellifera<\/jats:italic> to sublethal doses of glyphosate could cause head damage, which is mainly associated with behavior and metabolism. Simultaneously, imidacloprid can cause damage associated with metabolism as well as, neuronal damage, cellular stress, and impairment of the detoxification system. Regarding the thorax\u2013abdomen fractions, glyphosate could lead to cytoskeleton reorganization and a reduction in defense mechanisms, whereas imidacloprid could affect the coordination and impairment of the oxidative stress response.<\/jats:p>","DOI":"10.1007\/s11356-024-34185-x","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T15:22:41Z","timestamp":1720538561000},"page":"45954-45969","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Changes in the proteome of Apis mellifera acutely exposed to sublethal dosage of glyphosate and imidacloprid"],"prefix":"10.1007","volume":"31","author":[{"given":"Carlos Andr\u00e9s","family":"Maya-Aguirre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luz Dary","family":"Guti\u00e9rrez-Casta\u00f1eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luz Mary","family":"Salazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael","family":"Abreu-Villa\u00e7a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex Christian","family":"Manh\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7665-8955","authenticated-orcid":false,"given":"Nelson Enrique","family":"Arenas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,9]]},"reference":[{"key":"34185_CR1","doi-asserted-by":"publisher","first-page":"13513","DOI":"10.1021\/acs.jafc.8b05793","volume":"66","author":"YM Abd-Elhakim","year":"2018","unstructured":"Abd-Elhakim YM, Mohammed HH, Mohamed WAM (2018) Imidacloprid impacts on neurobehavioral performance, oxidative stress, and apoptotic events in the brain of adolescent and adult rats. 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