{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T10:54:23Z","timestamp":1780656863313,"version":"3.54.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"39","license":[{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31971185"],"award-info":[{"award-number":["31971185"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22376100"],"award-info":[{"award-number":["22376100"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"DOI":"10.1007\/s11356-024-34636-5","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T07:02:15Z","timestamp":1723100535000},"page":"51593-51603","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Low doses of acetyl trihexyl citrate plasticizer promote adipogenesis in hepatocytes and mice"],"prefix":"10.1007","volume":"31","author":[{"given":"Danyang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weigao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfa","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingzhe","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,8]]},"reference":[{"issue":"4","key":"34636_CR1","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1093\/clinchem\/20.4.470","volume":"20","author":"CC Allain","year":"1974","unstructured":"Allain CC, Poon LS, Chan CS, Richmond W, Fu PC (1974) Enzymatic determination of total serum cholesterol. Clin Chem 20(4):470\u2013475","journal-title":"Clin Chem"},{"issue":"1","key":"34636_CR2","first-page":"1","volume":"8","author":"M Alves-Bezerra","year":"2017","unstructured":"Alves-Bezerra M, Cohen DE (2017) Triglyceride Metabolism in the Liver. Compr Physiol 8(1):1\u20138","journal-title":"Compr Physiol"},{"key":"34636_CR3","doi-asserted-by":"crossref","unstructured":"Bian X, Liu R, Meng Y, Xing D, Xu D, Lu Z (2021) Lipid metabolism and cancer. J Exp Med 218(1):e20201606","DOI":"10.1084\/jem.20201606"},{"issue":"5","key":"34636_CR4","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1093\/clinchem\/19.5.476","volume":"19","author":"G Bucolo","year":"1973","unstructured":"Bucolo G, David H (1973) Quantitative determination of serum triglycerides by the use of enzymes. Clin Chem 19(5):476\u2013482","journal-title":"Clin Chem"},{"key":"34636_CR5","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.scitotenv.2015.09.036","volume":"541","author":"TT Bui","year":"2016","unstructured":"Bui TT, Giovanoulis G, Cousins AP, Magner J, Cousins IT, de Wit CA (2016) Human exposure, hazard and risk of alternative plasticizers to phthalate esters. Sci Total Environ 541:451\u2013467","journal-title":"Sci Total Environ"},{"key":"34636_CR6","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.envres.2018.11.034","volume":"171","author":"C Christia","year":"2019","unstructured":"Christia C, Poma G, Harrad S, de Wit CA, Sjostrom Y, Leonards P, Lamoree M, Covaci A (2019) Occurrence of legacy and alternative plasticizers in indoor dust from various EU countries and implications for human exposure via dust ingestion and dermal absorption. Environ Res 171:204\u2013212","journal-title":"Environ Res"},{"issue":"3","key":"34636_CR7","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/0009-8981(68)90041-7","volume":"22","author":"MJ Fletcher","year":"1968","unstructured":"Fletcher MJ (1968) A colorimetric method for estimating serum triglycerides. Clin Chim Acta 22(3):393\u2013397","journal-title":"Clin Chim Acta"},{"issue":"11","key":"34636_CR8","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1038\/nrendo.2015.163","volume":"11","author":"JJ Heindel","year":"2015","unstructured":"Heindel JJ, Newbold R, Schug TT (2015) Endocrine disruptors and obesity. Nat Rev Endocrinol 11(11):653\u2013661","journal-title":"Nat Rev Endocrinol"},{"issue":"3","key":"34636_CR9","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1152\/physrev.00002.2020","volume":"101","author":"DJ Hoffman","year":"2021","unstructured":"Hoffman DJ, Powell TL, Barrett ES, Hardy DB (2021) Developmental origins of metabolic diseases. Physiol Rev 101(3):739\u2013795","journal-title":"Physiol Rev"},{"key":"34636_CR10","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.envint.2015.08.005","volume":"85","author":"LE Johns","year":"2015","unstructured":"Johns LE, Cooper GS, Galizia A, Meeker JD (2015) Exposure assessment issues in epidemiology studies of phthalates. Environ Int 85:27\u201339","journal-title":"Environ Int"},{"issue":"Suppl 2","key":"34636_CR11","first-page":"1","volume":"21","author":"W Johnson Jr","year":"2002","unstructured":"Johnson W Jr (2002) Final report on the safety assessment of acetyl triethyl citrate, acetyl tributyl citrate, acetyl trihexyl citrate, and acetyl trioctyl citrate. Int J Toxicol 21(Suppl 2):1\u201317","journal-title":"Int J Toxicol"},{"issue":"8","key":"34636_CR12","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/S2213-8587(20)30129-7","volume":"8","author":"LG Kahn","year":"2020","unstructured":"Kahn LG, Philippat C, Nakayama SF, Slama R, Trasande L (2020) Endocrine-disrupting chemicals: implications for human health. Lancet Diabetes Endocrinol 8(8):703\u2013718","journal-title":"Lancet Diabetes Endocrinol"},{"key":"34636_CR13","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/j.scitotenv.2018.04.158","volume":"635","author":"D Kashyap","year":"2018","unstructured":"Kashyap D, Agarwal T (2018) Concentration and factors affecting the distribution of phthalates in the air and dust: A global scenario. Sci Total Environ 635:817\u2013827","journal-title":"Sci Total Environ"},{"issue":"8","key":"34636_CR14","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1080\/10934529.2011.579870","volume":"46","author":"T Kawakami","year":"2011","unstructured":"Kawakami T, Isama K, Matsuoka A (2011) Analysis of phthalic acid diesters, monoester, and other plasticizers in polyvinyl chloride household products in Japan. J Environ Sci Health A Tox Hazard Subst Environ Eng 46(8):855\u2013864","journal-title":"J Environ Sci Health A Tox Hazard Subst Environ Eng"},{"issue":"10","key":"34636_CR15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005599","volume":"11","author":"MM Keenan","year":"2015","unstructured":"Keenan MM, Liu B, Tang X, Wu J, Cyr D, Stevens RD, Ilkayeva O, Huang Z, Tollini LA, Murphy SK, Lucas J, Muoio DM, Kim SY, Chi JT (2015) ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via alpha-ketoglutarate. PLoS Genet 11(10):e1005599","journal-title":"PLoS Genet"},{"key":"34636_CR16","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.envres.2019.05.007","volume":"175","author":"H Kim","year":"2019","unstructured":"Kim H, Nam K, Oh S, Son S, Jeon D, Gye MC, Shin I (2019) Toxicological assessment of phthalates and their alternatives using human keratinocytes. Environ Res 175:316\u2013322","journal-title":"Environ Res"},{"issue":"8","key":"34636_CR17","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1002\/nbm.3334","volume":"28","author":"M Li","year":"2015","unstructured":"Li M, Vassiliou CC, Colucci LA, Cima MJ (2015) (1)H nuclear magnetic resonance (NMR) as a tool to measure dehydration in mice. NMR Biomed 28(8):1031\u20131039","journal-title":"NMR Biomed"},{"issue":"5","key":"34636_CR18","doi-asserted-by":"publisher","first-page":"2462","DOI":"10.1073\/pnas.1914553117","volume":"117","author":"K Liu","year":"2020","unstructured":"Liu K, Lin L, Li Q, Xue Y, Zheng F, Wang G, Zheng C, Du L, Hu M, Huang Y, Shao C, Kong X, Melino G, Shi Y, Wang Y (2020) Scd1 controls de novo beige fat biogenesis through succinate-dependent regulation of mitochondrial complex II. Proc Natl Acad Sci U S A 117(5):2462\u20132472","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"34636_CR19","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25(4):402\u2013408","journal-title":"Methods"},{"issue":"9","key":"34636_CR20","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1038\/nrendo.2017.51","volume":"13","author":"A Nadal","year":"2017","unstructured":"Nadal A, Quesada I, Tuduri E, Nogueiras R, Alonso-Magdalena P (2017) Endocrine-disrupting chemicals and the regulation of energy balance. Nat Rev Endocrinol 13(9):536\u2013546","journal-title":"Nat Rev Endocrinol"},{"key":"34636_CR21","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.envres.2019.02.001","volume":"172","author":"J Park","year":"2019","unstructured":"Park J, Park C, Gye MC, Lee Y (2019) Assessment of endocrine-disrupting activities of alternative chemicals for bis(2-ethylhexyl)phthalate. Environ Res 172:10\u201317","journal-title":"Environ Res"},{"key":"34636_CR22","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1146\/annurev.physiol.64.082201.154705","volume":"64","author":"P Rinaldo","year":"2002","unstructured":"Rinaldo P, Matern D, Bennett MJ (2002) Fatty acid oxidation disorders. Annu Rev Physiol 64:477\u2013502","journal-title":"Annu Rev Physiol"},{"issue":"6","key":"34636_CR23","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1007\/s00134-019-05594-1","volume":"45","author":"M Schetz","year":"2019","unstructured":"Schetz M, De Jong A, Deane AM, Druml W, Hemelaar P, Pelosi P, Pickkers P, Reintam-Blaser A, Roberts J, Sakr Y, Jaber S (2019) Obesity in the critically ill: a narrative review. Intensive Care Med 45(6):757\u2013769","journal-title":"Intensive Care Med"},{"issue":"3","key":"34636_CR24","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1111\/vox.12355","volume":"110","author":"K Serrano","year":"2016","unstructured":"Serrano K, Levin E, Chen D, Hansen A, Turner TR, Kurach J, Reidel A, Boecker WF, Acker JP, Devine DV (2016) An investigation of red blood cell concentrate quality during storage in paediatric-sized polyvinylchloride bags plasticized with alternatives to di-2-ethylhexyl phthalate (DEHP). Vox Sang 110(3):227\u2013235","journal-title":"Vox Sang"},{"issue":"6","key":"34636_CR25","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/S0163-7827(01)00010-8","volume":"40","author":"H Shimano","year":"2001","unstructured":"Shimano H (2001) Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes. Prog Lipid Res 40(6):439\u2013452","journal-title":"Prog Lipid Res"},{"key":"34636_CR26","first-page":"1181","volume":"4","author":"KM Somashekar","year":"2015","unstructured":"Somashekar KM, Mahima MR, Manjunath KC (2015) Contamination of Water Sources in Mysore City by Pesticide Residues and Plasticizer - A Cause of Health Concern. Intl Conf Water Resour Coast Ocean Eng (Icwrcoe\u201915) 4:1181\u20131188","journal-title":"Intl Conf Water Resour Coast Ocean Eng (Icwrcoe'15)"},{"key":"34636_CR27","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.trac.2018.10.025","volume":"110","author":"SA Strungaru","year":"2019","unstructured":"Strungaru SA, Jijie R, Nicoara M, Plavan G, Faggio C (2019) Micro- (nano) plastics in freshwater ecosystems: Abundance, toxicological impact and quantification methodology. Trac-Trends Anal Chem 110:116\u2013128","journal-title":"Trac-Trends Anal Chem"},{"issue":"9","key":"34636_CR28","doi-asserted-by":"publisher","first-page":"3634","DOI":"10.1021\/acs.est.2c08110","volume":"57","author":"H Tan","year":"2023","unstructured":"Tan H, Yang L, Liang X, Huang D, Qiao X, Dai Q, Chen D, Cai Z (2023) Nonphthalate Plasticizers in House Dust from Multiple Countries: An Increasing Threat to Humans. Environ Sci Technol 57(9):3634\u20133644","journal-title":"Environ Sci Technol"},{"issue":"5","key":"34636_CR29","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1007\/s00018-012-1096-0","volume":"70","author":"L Tong","year":"2013","unstructured":"Tong L (2013) Structure and function of biotin-dependent carboxylases. Cell Mol Life Sci 70(5):863\u2013891","journal-title":"Cell Mol Life Sci"},{"key":"34636_CR30","volume":"12","author":"Y Wang","year":"2022","unstructured":"Wang Y, Yu W, Li S, Guo D, He J, Wang Y (2022) Acetyl-CoA Carboxylases and Diseases. Front. Oncol 12:836058","journal-title":"Oncol"},{"issue":"5930","key":"34636_CR31","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1126\/science.1164097","volume":"324","author":"KE Wellen","year":"2009","unstructured":"Wellen KE, Hatzivassiliou G, Sachdeva UM, Bui TV, Cross JR, Thompson CB (2009) ATP-citrate lyase links cellular metabolism to histone acetylation. Science 324(5930):1076\u20131080","journal-title":"Science"},{"key":"34636_CR32","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/j.chemosphere.2018.04.077","volume":"204","author":"Y Xu","year":"2018","unstructured":"Xu Y, Gye MC (2018) Developmental toxicity of dibutyl phthalate and citrate ester plasticizers in Xenopus laevis embryos. Chemosphere 204:523\u2013534","journal-title":"Chemosphere"},{"key":"34636_CR33","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.envres.2019.03.004","volume":"172","author":"Y Xu","year":"2019","unstructured":"Xu Y, Park SH, Yoon KN, Park SJ, Gye MC (2019) Effects of citrate ester plasticizers and bis (2-ethylhexyl) phthalate in the OECD 28-day repeated-dose toxicity test (OECD TG 407). Environ Res 172:675\u2013683","journal-title":"Environ Res"},{"key":"34636_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2021.145418","volume":"771","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Jiao Y, Li Z, Tao Y, Yang Y (2021a) Hazards of phthalates (PAEs) exposure: A review of aquatic animal toxicology studies. Sci Total Environ 771:145418","journal-title":"Sci Total Environ"},{"issue":"20","key":"34636_CR35","doi-asserted-by":"publisher","first-page":"13961","DOI":"10.1021\/acs.est.1c04402","volume":"55","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Li J, Su G (2021b) Identifying Citric Acid Esters, a Class of Phthalate Substitute Plasticizers, in Indoor Dust via an Integrated Target, Suspect, and Characteristic Fragment-Dependent Screening Strategy. Environ Sci Technol 55(20):13961\u201313970","journal-title":"Environ Sci Technol"},{"key":"34636_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.152933","volume":"817","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Li J, Su G (2022) Comprehensively screening of citric acid ester (CAE) plasticizers in Chinese foodstuffs, and the food-based assessment of human exposure risk of CAEs. Sci Total Environ 817:152933","journal-title":"Sci Total Environ"},{"issue":"6","key":"34636_CR37","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1007\/s00217-011-1475-z","volume":"232","author":"PD Zygoura","year":"2011","unstructured":"Zygoura PD, Riganakos KA, Kontominas MG (2011) Study of the migration behavior of acetyl tributyl citrate from PVDC\/PVC film into fish fillets as affected by intermediate doses of electron beam radiation. Eur Food Res Technol 232(6):1017\u20131025","journal-title":"Eur Food Res Technol"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-024-34636-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11356-024-34636-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-024-34636-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T07:05:28Z","timestamp":1725433528000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11356-024-34636-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,8]]},"references-count":37,"journal-issue":{"issue":"39","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["34636"],"URL":"https:\/\/doi.org\/10.1007\/s11356-024-34636-5","relation":{},"ISSN":["1614-7499"],"issn-type":[{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,8]]},"assertion":[{"value":"24 August 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The protocols of animals were approved by the Animal Care and Use Committee of Nanjing University of Science & Technology.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}