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Meticulous efforts were made to minimize animal suffering and reduce external stress, pain, and discomfort sources. Furthermore, the number of animals used in the study was limited to the minimum required to obtain reliable and scientifically valid data.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"We confirm that there are no known conflicts of interest associated with this work, and there has been no significant financial support for this work that could have influenced its outcome. Furthermore, we ensure that the manuscript has been read and approved by all named authors and that no other persons have satisfied the criteria for authorship but are not listed. We further confirm that all have agreed on the order of authors listed in the manuscript of us. Due care has been taken to ensure the integrity of the work.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}