{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T23:12:28Z","timestamp":1788390748261,"version":"build-2803163510"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"13","license":[{"start":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T00:00:00Z","timestamp":1741910400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T00:00:00Z","timestamp":1741910400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and engineering research board","doi-asserted-by":"crossref","award":["CRG\/2021\/002625"],"award-info":[{"award-number":["CRG\/2021\/002625"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["5\/4\/7\u20134\/Nephro\/2021-NCD-II"],"award-info":[{"award-number":["5\/4\/7\u20134\/Nephro\/2021-NCD-II"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"DOI":"10.1007\/s11356-025-36229-2","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T09:17:19Z","timestamp":1741943839000},"page":"8498-8517","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Prenatal arsenic exposure alters EZH2\/H3K27me3 to induce RKIP\/NF-kB\/ERK1\/2-mediated early-onset kidney disease in mouse offspring"],"prefix":"10.1007","volume":"32","author":[{"given":"Sukhveer","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anchal","family":"Chauhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavita","family":"Koshta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samiya","family":"Baby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratnakar","family":"Tiwari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj Ramji","family":"Jagdale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahadeo","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vineeta","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhirendra","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,14]]},"reference":[{"key":"36229_CR1","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.3109\/0886022X.2015.1074462","volume":"37","author":"M Adil","year":"2015","unstructured":"Adil M, Kandhare AD, Visnagri A, Bodhankar SL (2015) Naringin ameliorates sodium arsenite-induced renal and hepatic toxicity in rats: decisive role of KIM-1, caspase-3, TGF-beta, and TNF-alpha. Ren Fail 37:1396\u20131407","journal-title":"Ren Fail"},{"key":"36229_CR2","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.envres.2017.05.010","volume":"157","author":"KS Almberg","year":"2017","unstructured":"Almberg KS, Turyk ME, Jones RM, Rankin K, Freels S, Graber JM, Stayner LT (2017) Arsenic in drinking water and adverse birth outcomes in Ohio. Environ Res 157:52\u201359","journal-title":"Environ Res"},{"key":"36229_CR3","doi-asserted-by":"publisher","first-page":"106019","DOI":"10.1016\/j.envint.2020.106019","volume":"144","author":"R Babich","year":"2020","unstructured":"Babich R, Ulrich JC, Ekanayake E, Massarsky A, De Silva P, Manage PM, Jackson BP, Ferguson PL, Di Giulio RT, Drummond IA, Jayasundara N (2020) Kidney developmental effects of metal-herbicide mixtures: implications for chronic kidney disease of unknown etiology. Environ Int 144:106019","journal-title":"Environ Int"},{"key":"36229_CR4","doi-asserted-by":"publisher","first-page":"643972","DOI":"10.3389\/fphar.2021.643972","volume":"12","author":"M Balali-Mood","year":"2021","unstructured":"Balali-Mood M, Naseri K, Tahergorabi Z, Khazdair MR, Sadeghi M (2021) Toxic mechanisms of five heavy metals: mercury, lead, chromium, cadmium, and arsenic. Front Pharmacol 12:643972","journal-title":"Front Pharmacol"},{"key":"36229_CR5","unstructured":"Bancroft JD, Gamble M (2008): Theory and practice of histological techniques. Elsevier health sciences"},{"key":"36229_CR6","doi-asserted-by":"publisher","first-page":"e1920964","DOI":"10.1001\/jamanetworkopen.2019.20964","volume":"3","author":"PM Barrett","year":"2020","unstructured":"Barrett PM, McCarthy FP, Kublickiene K, Cormican S, Judge C, Evans M, Kublickas M, Perry IJ, Stenvinkel P, Khashan AS (2020) Adverse pregnancy outcomes and long-term maternal kidney disease: a systematic review and meta-analysis. JAMA Netw Open 3:e1920964","journal-title":"JAMA Netw Open"},{"key":"36229_CR7","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1086\/679906","volume":"88","author":"WW Burggren","year":"2015","unstructured":"Burggren WW, Mueller CA (2015) Developmental critical windows and sensitive periods as three-dimensional constructs in time and space. Physiol Biochem Zool 88:91\u2013102","journal-title":"Physiol Biochem Zool"},{"key":"36229_CR8","doi-asserted-by":"publisher","first-page":"6904","DOI":"10.1038\/s41598-024-56547-8","volume":"14","author":"A Chauhan","year":"2024","unstructured":"Chauhan A, Gangopadhyay S, Koshta K, Singh S, Singh D, Srivastava V (2024a) Activated fibroblasts modify keratinocyte stem niche through TET1 and IL-6 to promote their rapid transformation in a mouse model of prenatal arsenic exposure. Sci Rep 14:6904","journal-title":"Sci Rep"},{"key":"36229_CR9","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1002\/mc.23690","volume":"63","author":"A Chauhan","year":"2024","unstructured":"Chauhan A, Gangopadhyay S, Sharma V, Singh S, Koshta K, Singh D, Ansari KM, Srivastava V (2024b) Prenatal arsenic exposure alters keratinocyte stem cell fate through persistent activation of IGF2R-MAPK cascade leading to aggravated skin carcinogenesis in mice offspring. Mol Carcinog 63:817\u2013833","journal-title":"Mol Carcinog"},{"key":"36229_CR10","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1093\/ije\/dyr022","volume":"40","author":"Y Chen","year":"2011","unstructured":"Chen Y, Parvez F, Liu M, Pesola GR, Gamble MV, Slavkovich V, Islam T, Ahmed A, Hasan R, Graziano JH, Ahsan H (2011) Association between arsenic exposure from drinking water and proteinuria: results from the Health Effects of Arsenic Longitudinal Study. Int J Epidemiol 40:828\u2013835","journal-title":"Int J Epidemiol"},{"key":"36229_CR11","doi-asserted-by":"publisher","first-page":"108681","DOI":"10.1016\/j.envres.2019.108681","volume":"178","author":"Y Chen","year":"2019","unstructured":"Chen Y, Wu F, Liu X, Parvez F, LoIacono NJ, Gibson EA, Kioumourtzoglou MA, Levy D, Shahriar H, Uddin MN, Islam T, Lomax A, Saxena R, Sanchez T, Santiago D, Ellis T, Ahsan H, Wasserman GA, Graziano JH (2019) Early life and adolescent arsenic exposure from drinking water and blood pressure in adolescence. Environ Res 178:108681","journal-title":"Environ Res"},{"key":"36229_CR12","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1042\/CS20160047","volume":"130","author":"G Cobo","year":"2016","unstructured":"Cobo G, Hecking M, Port FK, Exner I, Lindholm B, Stenvinkel P, Carrero JJ (2016) Sex and gender differences in chronic kidney disease: progression to end-stage renal disease and haemodialysis. Clin Sci (Lond) 130:1147\u20131163","journal-title":"Clin Sci (Lond)"},{"key":"36229_CR13","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/S0140-6736(20)30045-3","volume":"395","author":"GBDCKD Collaboration","year":"2020","unstructured":"Collaboration GBDCKD (2020) Global, regional, and national burden of chronic kidney disease, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 395:709\u2013733","journal-title":"Lancet"},{"key":"36229_CR14","doi-asserted-by":"publisher","first-page":"8414047","DOI":"10.1155\/2022\/8414047","volume":"2022","author":"X Duan","year":"2022","unstructured":"Duan X, Xu G, Li J, Yan N, Li X, Liu X, Li B (2022) Arsenic induces continuous inflammation and regulates Th1\/Th2\/Th17\/Treg balance in liver and kidney in vivo. Mediat Inflamm 2022:8414047","journal-title":"Mediat Inflamm"},{"key":"36229_CR15","doi-asserted-by":"publisher","first-page":"e307","DOI":"10.1016\/S2214-109X(16)00071-1","volume":"4","author":"B Ene-Iordache","year":"2016","unstructured":"Ene-Iordache B et al (2016) Chronic kidney disease and cardiovascular risk in six regions of the world (ISN-KDDC): a cross-sectional study. Lancet Glob Health 4:e307\u2013e319","journal-title":"Lancet Glob Health"},{"issue":"2011","key":"36229_CR16","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/kisup.2014.3","volume":"4","author":"AB Farris","year":"2014","unstructured":"Farris AB, Alpers CE (2014) What is the best way to measure renal fibrosis?: a pathologist\u2019s perspective. Kidney Int Suppl 4(2011):9\u201315","journal-title":"Kidney Int Suppl"},{"key":"36229_CR17","first-page":"pdb prot4986","volume":"2008","author":"AH Fischer","year":"2008","unstructured":"Fischer AH, Jacobson KA, Rose J, Zeller R (2008) Hematoxylin and eosin staining of tissue and cell sections. CSH Protoc 2008:pdb prot4986","journal-title":"CSH Protoc"},{"key":"36229_CR18","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.freeradbiomed.2011.04.008","volume":"51","author":"SJ Flora","year":"2011","unstructured":"Flora SJ (2011) Arsenic-induced oxidative stress and its reversibility. Free Radic Biol Med 51:257\u2013281","journal-title":"Free Radic Biol Med"},{"key":"36229_CR19","doi-asserted-by":"publisher","first-page":"e207","DOI":"10.1371\/journal.pgen.0030207","volume":"3","author":"RC Fry","year":"2007","unstructured":"Fry RC, Navasumrit P, Valiathan C, Svensson JP, Hogan BJ, Luo M, Bhattacharya S, Kandjanapa K, Soontararuks S, Nookabkaew S, Mahidol C, Ruchirawat M, Samson LD (2007) Activation of inflammation\/NF-kappaB signaling in infants born to arsenic-exposed mothers. PLoS Genet 3:e207","journal-title":"PLoS Genet"},{"key":"36229_CR20","doi-asserted-by":"publisher","first-page":"e161316","DOI":"10.1172\/jci.insight.161316","volume":"8","author":"PI Good","year":"2023","unstructured":"Good PI, Li L, Hurst HA, Serrano Herrera I, Xu K, Rao M, Bateman DA, Al-Awqati Q, D\u2019Agati VD, Costantini F, Lin F (2023) Low nephron endowment increases susceptibility to renal stress and chronic kidney disease. JCI Insight 8:e161316","journal-title":"JCI Insight"},{"key":"36229_CR21","doi-asserted-by":"publisher","first-page":"2439","DOI":"10.1038\/nprot.2007.304","volume":"2","author":"L Graham","year":"2007","unstructured":"Graham L, Orenstein JM (2007) Processing tissue and cells for transmission electron microscopy in diagnostic pathology and research. Nat Protoc 2:2439\u20132450","journal-title":"Nat Protoc"},{"key":"36229_CR22","doi-asserted-by":"publisher","first-page":"1161436","DOI":"10.3389\/fimmu.2023.1161436","volume":"14","author":"Y Guo","year":"2023","unstructured":"Guo Y, Yuan Z, Hu Z, Gao Y, Guo H, Zhu H, Hong K, Cen K, Mai Y, Bai Y, Yang X (2023) Diagnostic model constructed by five EMT-related genes for renal fibrosis and reflecting the condition of immune-related cells. Front Immunol 14:1161436","journal-title":"Front Immunol"},{"key":"36229_CR23","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1002\/biof.2027","volume":"50","author":"MS Iheanacho","year":"2024","unstructured":"Iheanacho MS, Kandel R, Roy P, Singh KP (2024) Epigallocatechin-3-gallate attenuates arsenic-inducedfibrogenic changes in human kidney epithelial cells through reversal of epigenetic aberrations andantioxidant activities. Biofactors 50:542\u2013557","journal-title":"Biofactors"},{"key":"36229_CR24","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/s00244-006-0053-z","volume":"52","author":"SH Jadhav","year":"2007","unstructured":"Jadhav SH, Sarkar SN, Aggarwal M, Tripathi HC (2007) Induction of oxidative stress in erythrocytes of male rats subchronically exposed to a mixture of eight metals found as groundwater contaminants in different parts of India. Arch Environ Contam Toxicol 52:145\u2013151","journal-title":"Arch Environ Contam Toxicol"},{"key":"36229_CR25","doi-asserted-by":"publisher","first-page":"123396","DOI":"10.1016\/j.envpol.2024.123396","volume":"345","author":"H Ji","year":"2024","unstructured":"Ji H, Bi Z, Pawar AS, Seno A, Almutairy BS, Fu Y, Qiu Y, Zhang W, Wang Z, Thakur C, Cui H, Yang L, Chen F (2024) Genomic and epigenetic characterization of the arsenic-induced oncogenic microRNA-21. Environ Pollut 345:123396","journal-title":"Environ Pollut"},{"key":"36229_CR26","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/j.ccr.2013.04.008","volume":"23","author":"E Kim","year":"2013","unstructured":"Kim E, Kim M, Woo DH, Shin Y, Shin J, Chang N, Oh YT, Kim H, Rheey J, Nakano I, Lee C, Joo KM, Rich JN, Nam DH, Lee J (2013) Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells. Cancer Cell 23:839\u2013852","journal-title":"Cancer Cell"},{"key":"36229_CR27","doi-asserted-by":"publisher","first-page":"141493","DOI":"10.1016\/j.chemosphere.2024.141493","volume":"352","author":"K Koshta","year":"2024","unstructured":"Koshta K, Chauhan A, Singh S, Gaikwad AN, Kumar M, Srivastava V (2024a) Altered Igf2 imprint leads to accelerated adipogenesis and early onset of metabolic syndrome in male mice following gestational arsenic exposure. Chemosphere 352:141493","journal-title":"Chemosphere"},{"key":"36229_CR28","doi-asserted-by":"publisher","first-page":"108929","DOI":"10.1016\/j.envint.2024.108929","volume":"190","author":"K Koshta","year":"2024","unstructured":"Koshta K, Chauhan A, Singh S, Srivastava V (2024b) Prenatal arsenic exposure alters EZH2-H3K27me3 occupancy at TNF-alpha promoter leading to insulin resistance and metabolic syndrome in a mouse model. Environ Int 190:108929","journal-title":"Environ Int"},{"key":"36229_CR29","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.kisu.2021.11.003","volume":"12","author":"CP Kovesdy","year":"2022","unstructured":"Kovesdy CP (2022) Epidemiology of chronic kidney disease: an update 2022. Kidney Int Suppl (2011) 12:7\u201311","journal-title":"Kidney Int Suppl (2011)"},{"key":"36229_CR30","doi-asserted-by":"publisher","first-page":"2893","DOI":"10.1101\/gad.1035902","volume":"16","author":"A Kuzmichev","year":"2002","unstructured":"Kuzmichev A, Nishioka K, Erdjument-Bromage H, Tempst P, Reinberg D (2002) Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev 16:2893\u20132905","journal-title":"Genes Dev"},{"key":"36229_CR31","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1369\/0022155414545787","volume":"62","author":"R Lattouf","year":"2014","unstructured":"Lattouf R, Younes R, Lutomski D, Naaman N, Godeau G, Senni K, Changotade S (2014) Picrosirius red staining: a useful tool to appraise collagen networks in normal and pathological tissues. J Histochem Cytochem 62:751\u2013758","journal-title":"J Histochem Cytochem"},{"key":"36229_CR32","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1038\/s41581-022-00590-z","volume":"18","author":"L Li","year":"2022","unstructured":"Li L, Fu H, Liu Y (2022) The fibrogenic niche in kidney fibrosis: components and mechanisms. Nat Rev Nephrol 18:545\u2013557","journal-title":"Nat Rev Nephrol"},{"key":"36229_CR33","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1080\/0886022X.2021.1901739","volume":"43","author":"HY Ma","year":"2021","unstructured":"Ma HY, Chen S, Du Y (2021) Estrogen and estrogen receptors in kidney diseases. Ren Fail 43:619\u2013642","journal-title":"Ren Fail"},{"key":"36229_CR34","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/978-1-4939-8935-5_25","volume":"1897","author":"S Magaki","year":"2019","unstructured":"Magaki S, Hojat SA, Wei B, So A, Yong WH (2019) An introduction to the performance of immunohistochemistry. Methods Mol Biol 1897:289\u2013298","journal-title":"Methods Mol Biol"},{"key":"36229_CR35","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/s00210-019-01734-y","volume":"393","author":"AO Maghmomeh","year":"2020","unstructured":"Maghmomeh AO, El-Gayar AM, El-Karef A, Abdel-Rahman N (2020) Arsenic trioxide and curcumin attenuate cisplatin-induced renal fibrosis in rats through targeting Hedgehog signaling. Naunyn Schmiedebergs Arch Pharmacol 393:303\u2013313","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"36229_CR36","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1111\/j.1742-7843.2010.00660.x","volume":"108","author":"VP Markowski","year":"2011","unstructured":"Markowski VP, Currie D, Reeve EA, Thompson D, Wise JP Sr (2011) Tissue-specific and dose-related accumulation of arsenic in mouse offspring following maternal consumption of arsenic-contaminated water. Basic Clin Pharmacol Toxicol 108:326\u2013332","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"36229_CR37","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1126\/science.aba1510","volume":"368","author":"J Podgorski","year":"2020","unstructured":"Podgorski J, Berg M (2020) Global threat of arsenic in groundwater. Science 368:845\u2013850","journal-title":"Science"},{"key":"36229_CR38","doi-asserted-by":"publisher","first-page":"225","DOI":"10.2147\/IJNRD.S319933","volume":"14","author":"D Puthiyottil","year":"2021","unstructured":"Puthiyottil D, Priyamvada PS, Kumar MN, Chellappan A, Zachariah B, Parameswaran S (2021) Role of urinary beta 2 microglobulin and kidney injury molecule-1 in predicting kidney function at one year following acute kidney injury. Int J Nephrol Renovasc Dis 14:225\u2013234","journal-title":"Int J Nephrol Renovasc Dis"},{"key":"36229_CR39","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/S0162-0134(03)00235-6","volume":"96","author":"Y Qian","year":"2003","unstructured":"Qian Y, Castranova V, Shi X (2003) New perspectives in arsenic-induced cell signal transduction. J Inorg Biochem 96:271\u2013278","journal-title":"J Inorg Biochem"},{"key":"36229_CR40","doi-asserted-by":"publisher","first-page":"542","DOI":"10.3109\/0886022X.2015.1013419","volume":"37","author":"ML Robles-Osorio","year":"2015","unstructured":"Robles-Osorio ML, Sabath-Silva E, Sabath E (2015) Arsenic-mediated nephrotoxicity. Ren Fail 37:542\u2013547","journal-title":"Ren Fail"},{"key":"36229_CR41","doi-asserted-by":"publisher","first-page":"29927","DOI":"10.1007\/s11356-020-09354-3","volume":"27","author":"ML Sall","year":"2020","unstructured":"Sall ML, Diaw AKD, Gningue-Sall D, Efremova Aaron S, Aaron JJ (2020) Toxic heavy metals: impact on the environment and human health, and treatment with conducting organic polymers, a review. Environ Sci Pollut Res Int 27:29927\u201329942","journal-title":"Environ Sci Pollut Res Int"},{"key":"36229_CR42","first-page":"58520","volume":"21","author":"L Scarfe","year":"2018","unstructured":"Scarfe L, Schock-Kusch D, Ressel L, Friedemann J, Shulhevich Y, Murray P, Wilm B, de Caestecker M (2018) Transdermal measurement of glomerular filtration rate in mice. J Vis Exp 21:58520","journal-title":"J Vis Exp"},{"key":"36229_CR43","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1038\/nprot.2008.73","volume":"3","author":"TD Schmittgen","year":"2008","unstructured":"Schmittgen TD, Livak KJ (2008) Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 3:1101\u20131108","journal-title":"Nat Protoc"},{"key":"36229_CR44","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1038\/ki.2011.31","volume":"79","author":"D Schock-Kusch","year":"2011","unstructured":"Schock-Kusch D, Xie Q, Shulhevich Y, Hesser J, Stsepankou D, Sadick M, Koenig S, Hoecklin F, Pill J, Gretz N (2011) Transcutaneous assessment of renal function in conscious rats with a device for measuring FITC-sinistrin disappearance curves. Kidney Int 79:1254\u20131258","journal-title":"Kidney Int"},{"key":"36229_CR45","doi-asserted-by":"publisher","first-page":"7180","DOI":"10.1007\/s11356-020-11035-0","volume":"28","author":"AK Sharma","year":"2021","unstructured":"Sharma AK, Kaur J, Kaur T, Singh B, Yadav HN, Pathak D, Singh AP (2021) Ameliorative role of bosentan, an endothelin receptor antagonist, against sodium arsenite-induced renal dysfunction in rats. Environ Sci Pollut Res Int 28:7180\u20137190","journal-title":"Environ Sci Pollut Res Int"},{"key":"36229_CR46","doi-asserted-by":"publisher","first-page":"116004","DOI":"10.1016\/j.taap.2022.116004","volume":"443","author":"V Sharma","year":"2022","unstructured":"Sharma V, Gangopadhyay S, Shukla S, Chauhan A, Singh S, Singh RD, Tiwari R, Singh D, Srivastava V (2022) Prenatal exposure to arsenic promotes sterile inflammation through the polycomb repressive element EZH2 and accelerates skin tumorigenesis in mouse. Toxicol Appl Pharmacol 443:116004","journal-title":"Toxicol Appl Pharmacol"},{"key":"36229_CR47","doi-asserted-by":"publisher","first-page":"1045692","DOI":"10.3389\/fmed.2022.1045692","volume":"9","author":"RD Singh","year":"2022","unstructured":"Singh RD, Tiwari R, Sharma V, Khan H, Gangopadhyay S, Singh S, Koshta K, Shukla S, Arjaria N, Mandrah K, Jagdale PR, Patnaik S, Roy SK, Singh D, Giri AK, Srivastava V (2022) Prenatal arsenic exposure induces immunometabolic alteration and renal injury in rats. Front Med (Lausanne) 9:1045692","journal-title":"Front Med (Lausanne)"},{"key":"36229_CR48","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.envres.2015.03.038","volume":"140","author":"H Skroder","year":"2015","unstructured":"Skroder H, Hawkesworth S, Kippler M, El Arifeen S, Wagatsuma Y, Moore SE, Vahter M (2015) Kidney function and blood pressure in preschool-aged children exposed to cadmium and arsenic\u2013potential alleviation by selenium. Environ Res 140:205\u2013213","journal-title":"Environ Res"},{"key":"36229_CR49","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1289\/ehp.1104867","volume":"120","author":"AH Smith","year":"2012","unstructured":"Smith AH, Marshall G, Liaw J, Yuan Y, Ferreccio C, Steinmaus C (2012) Mortality in young adults following in utero and childhood exposure to arsenic in drinking water. Environ Health Perspect 120:1527\u20131531","journal-title":"Environ Health Perspect"},{"key":"36229_CR50","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.toxlet.2020.07.029","volume":"333","author":"C Sosa","year":"2020","unstructured":"Sosa C, Guillen N, Lucea S, Sorribas V (2020) Effects of oral exposure to arsenite on arsenic metabolism and transport in rat kidney. Toxicol Lett 333:4\u201312","journal-title":"Toxicol Lett"},{"key":"36229_CR51","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1021\/acs.chemrestox.9b00464","volume":"33","author":"LM Tam","year":"2020","unstructured":"Tam LM, Price NE, Wang Y (2020) Molecular mechanisms of arsenic-induced disruption of DNA repair. Chem Res Toxicol 33:709\u2013726","journal-title":"Chem Res Toxicol"},{"key":"36229_CR52","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1016\/j.scitotenv.2019.04.409","volume":"686","author":"X Tian","year":"2019","unstructured":"Tian X, Feng J, Dong N, Lyu Y, Wei C, Li B, Ma Y, Xie J, Qiu Y, Song G, Ren X, Yan X (2019) Subchronic exposure to arsenite and fluoride from gestation to puberty induces oxidative stress and disrupts ultrastructure in the kidneys of rat offspring. Sci Total Environ 686:1229\u20131237","journal-title":"Sci Total Environ"},{"key":"36229_CR53","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1007\/s00204-019-02651-y","volume":"94","author":"X Tian","year":"2020","unstructured":"Tian X, Xie J, Chen X, Dong N, Feng J, Gao Y, Tian F, Zhang W, Qiu Y, Niu R, Ren X, Yan X (2020) Deregulation of autophagy is involved in nephrotoxicity of arsenite and fluoride exposure during gestation to puberty in rat offspring. Arch Toxicol 94:749\u2013760","journal-title":"Arch Toxicol"},{"key":"36229_CR54","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1080\/17435390.2021.1909767","volume":"15","author":"R Tiwari","year":"2021","unstructured":"Tiwari R, Singh RD, Binwal M, Srivastav AK, Singh N, Khan H, Gangopadhyay S, Argaria N, Saxena PN, Roy SK, Kumar M, Sharma V, Srivastava V (2021) Perinatal exposure to silver nanoparticles reprograms immunometabolism and promotes pancreatic beta-cell death and kidney damage in mice. Nanotoxicology 15:636\u2013660","journal-title":"Nanotoxicology"},{"key":"36229_CR55","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.7150\/ijms.51594","volume":"18","author":"HJ Tsai","year":"2021","unstructured":"Tsai HJ, Wu PY, Huang JC, Chen SC (2021) Environmental pollution and chronic kidney disease. Int J Med Sci 18:1121\u20131129","journal-title":"Int J Med Sci"},{"key":"36229_CR56","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1021\/pr800545q","volume":"8","author":"MK Tuck","year":"2009","unstructured":"Tuck MK, Chan DW, Chia D, Godwin AK, Grizzle WE, Krueger KE, Rom W, Sanda M, Sorbara L, Stass S, Wang W, Brenner DE (2009) Standard operating procedures for serum and plasma collection: early detection research network consensus statement standard operating procedure integration working group. J Proteome Res 8:113\u2013117","journal-title":"J Proteome Res"},{"key":"36229_CR57","doi-asserted-by":"publisher","first-page":"110742","DOI":"10.1016\/j.ecoenv.2020.110742","volume":"200","author":"J Wang","year":"2020","unstructured":"Wang J, Zhang G, Lin Z, Luo Y, Fang H, Yang L, Xie J, Guo L (2020) Determination of arsenicals in mouse tissues after simulated exposure to arsenic from rice for sixteen weeks and the effects on histopathological features. Ecotoxicol Environ Saf 200:110742","journal-title":"Ecotoxicol Environ Saf"},{"key":"36229_CR58","doi-asserted-by":"publisher","first-page":"2067","DOI":"10.1038\/s41401-021-00837-8","volume":"43","author":"L Wen","year":"2022","unstructured":"Wen L, Tao SH, Guo F, Li LZ, Yang HL, Liang Y, Zhang LD, Ma L, Fu P (2022) Selective EZH2 inhibitorzld1039 alleviates inflammation in cisplatin-induced acute kidney injury partially by enhancing RKIP andsuppressing NF-kappaB p65 pathway. Acta Pharmacol Sin 43:2067\u20132080","journal-title":"Acta Pharmacol Sin"},{"key":"36229_CR59","unstructured":"WHO (2023) Noncommunicable diseases, https:\/\/www.who.int\/news-room\/factsheets\/detail\/noncommunicable-diseases. Accessed 16 May (2024)"},{"key":"36229_CR60","doi-asserted-by":"publisher","first-page":"2161","DOI":"10.1002\/tox.23330","volume":"36","author":"G Xu","year":"2021","unstructured":"Xu G, Gu Y, Yan N, Li Y, Sun L, Li B (2021) Curcumin functions as an anti-inflammatory and antioxidant agent on arsenic-induced hepatic and kidney injury by inhibiting MAPKs\/NF-kappaB and activating Nrf2 pathways. Environ Toxicol 36:2161\u20132173","journal-title":"Environ Toxicol"},{"key":"36229_CR61","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1007\/BF01687364","volume":"19","author":"S Yamabayashi","year":"1987","unstructured":"Yamabayashi S (1987) Periodic acid-Schiff-alcian blue: a method for the differential staining of glycoproteins. Histochem J 19:565\u2013571","journal-title":"Histochem J"},{"key":"36229_CR62","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1080\/19396368.2018.1480076","volume":"64","author":"JL Young","year":"2018","unstructured":"Young JL, Cai L, States JC (2018) Impact of prenatal arsenic exposure on chronic adult diseases. Syst Biol Reprod Med 64:469\u2013483","journal-title":"Syst Biol Reprod Med"},{"key":"36229_CR63","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.1681\/ASN.2015050500","volume":"27","author":"W Yin","year":"2016","unstructured":"Yin W, Naini SM, Chen G, Hentschel DM, Humphreys BD, Bonventre JV (2016) Mammalian Target of Rapamycin Mediates Kidney Injury Molecule 1-Dependent Tubule Injury in a Surrogate Model. J Am Soc Nephrol 27:1943\u201357","journal-title":"J Am Soc Nephrol"},{"key":"36229_CR64","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1053\/j.ajkd.2012.09.011","volume":"61","author":"LY Zheng","year":"2013","unstructured":"Zheng LY, Umans JG, Tellez-Plaza M, Yeh F, Francesconi KA, Goessler W, Silbergeld EK, Guallar E, Howard BV, Weaver VM, Navas-Acien A (2013) Urine arsenic and prevalent albuminuria: evidence from a population-based study. Am J Kidney Dis 61:385\u2013394","journal-title":"Am J Kidney Dis"},{"key":"36229_CR65","doi-asserted-by":"publisher","first-page":"2092","DOI":"10.1681\/ASN.2015040457","volume":"27","author":"X Zhou","year":"2016","unstructured":"Zhou X, Zang X, Ponnusamy M, Masucci MV, Tolbert E, Gong R, Zhao TC, Liu N, Bayliss G, Dworkin LD, Zhuang S (2016) Enhancer of zeste homolog 2 inhibition attenuates renal fibrosis by maintaining Smad7 and phosphatase and tensin homolog expression. J Am Soc Nephrol 27:2092\u20132108","journal-title":"J Am Soc Nephrol"},{"key":"36229_CR66","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1038\/s41419-018-1012-0","volume":"9","author":"X Zhou","year":"2018","unstructured":"Zhou X, Zang X, Guan Y, Tolbert T, Zhao TC, Bayliss G, Zhuang S (2018) Targeting enhancer of zeste homolog 2 protects against acute kidney injury. Cell Death Dis 9:1067","journal-title":"Cell Death Dis"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-025-36229-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11356-025-36229-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-025-36229-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T16:36:10Z","timestamp":1743525370000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11356-025-36229-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,14]]},"references-count":66,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2025,3]]}},"alternative-id":["36229"],"URL":"https:\/\/doi.org\/10.1007\/s11356-025-36229-2","relation":{},"ISSN":["1614-7499"],"issn-type":[{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,14]]},"assertion":[{"value":"25 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This manuscript number IITR\/SEC\/MS\/2023\/101 was approved for the publication by the Ethical Committee of the CSIR-Indian Institute of Toxicology Research, Lucknow, India.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare that we consent to participate in a study, but object to having their data published in the journal.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}