{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:50:12Z","timestamp":1790419812581,"version":"4.1.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"24","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"DOI":"10.1007\/s11356-025-36474-5","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T10:40:58Z","timestamp":1748601658000},"page":"14782-14795","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Adverse effects of a realistic concentration of human exposure to microplastics on markers of placental barrier permeability in pregnant rats"],"prefix":"10.1007","volume":"32","author":[{"given":"Asma","family":"Haddadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Venditti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaouthar","family":"Kessabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4025-8765","authenticated-orcid":false,"given":"Imed","family":"Messaoudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,30]]},"reference":[{"key":"36474_CR1","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1021\/acs.estlett.2c00186","volume":"9","author":"Z Aghaei","year":"2022","unstructured":"Aghaei Z, Sled JG, Kingdom JC, Baschat AA, Helm PA, Jobst KJ, Cahill LS (2022) Maternal exposure to polystyrene micro and nanoplastics causes fetal growth restriction in mice. Environ Sci Technol Lett 9:426\u2013430. https:\/\/doi.org\/10.1021\/acs.estlett.2c00186","journal-title":"Environ Sci Technol Lett"},{"key":"36474_CR2","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s12989-024-00595-5","volume":"21","author":"J Bai","year":"2024","unstructured":"Bai J, Wang Y, Deng S, Yang Y, Chen S, Wu Z (2024) Microplastics caused embryonic growth retardation and placental dysfunction in pregnant mice by activating GRP78\/IRE1\u03b1\/ JNK axis induced apoptosis and endoplasmic reticulum stress. Part Fibre Toxicol 21:36. https:\/\/doi.org\/10.1186\/s12989-024-00595-5","journal-title":"Part Fibre Toxicol"},{"key":"36474_CR3","doi-asserted-by":"publisher","first-page":"56700","DOI":"10.1007\/s11356-023-26429-z","volume":"30","author":"M Ben Hassine","year":"2023","unstructured":"Ben Hassine M, Venditti M, Ben Rhouma M, Minucci S, Messaoudi I (2023) Combined effect of polystyrene microplastics and cadmium on rat blood-testis barrier integrity and sperm quality. ESPR 30:56700\u201356712. https:\/\/doi.org\/10.1007\/s11356-023-26429-z","journal-title":"ESPR"},{"key":"36474_CR4","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1006\/abio.1976.9999","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248\u2013254. https:\/\/doi.org\/10.1006\/abio.1976.9999","journal-title":"Anal Biochem"},{"key":"36474_CR5","doi-asserted-by":"publisher","first-page":"921","DOI":"10.3390\/pharmaceutics13070921","volume":"13","author":"T Braun","year":"2021","unstructured":"Braun T, Ehrlich L, Henrich W, Koeppel S, Lomako I, Schwabl P, Liebmann B (2021) Detection of microplastic in human placenta and meconium in a clinical setting. Pharmaceutics 13:921. https:\/\/doi.org\/10.3390\/pharmaceutics13070921","journal-title":"Pharmaceutics"},{"key":"36474_CR6","doi-asserted-by":"publisher","unstructured":"Buege JA, Aust SD (1978) Microsomal lipid peroxidation. In: Fleischer S, Packer L (eds) Methods in enzymology. Academic Press, Elsevier, pp 302\u2013310. https:\/\/doi.org\/10.1016\/s0076-6879(78)52032-6","DOI":"10.1016\/s0076-6879(78)52032-6"},{"key":"36474_CR7","doi-asserted-by":"publisher","first-page":"720","DOI":"10.3390\/nano13040720","volume":"13","author":"CM Cary","year":"2023","unstructured":"Cary CM, DeLoid GM, Yang Z, Bitounis D, Polunas M, Goedken MJ, Buckley B, Cheatham B, Stapleton PA, Demokritou P (2023) Ingested polystyrene nanospheres translocate to placenta and fetal tissues in pregnant rats: potential health implications. Nanomaterials 13:720. https:\/\/doi.org\/10.3390\/nano13040720","journal-title":"Nanomaterials"},{"key":"36474_CR8","first-page":"283","volume-title":"Handbook methods for oxygen radical research","author":"A Claiborne","year":"1985","unstructured":"Claiborne A (1985) Catalase activity. In: Greenwald RA (ed) Handbook methods for oxygen radical research. CRC Press, pp 283\u2013284"},{"key":"36474_CR9","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1071\/rd05121","volume":"18","author":"JC Cross","year":"2006","unstructured":"Cross JC (2006) Placental function in development and disease. Reprod Fertil Dev 18:71\u201376. https:\/\/doi.org\/10.1071\/rd05121","journal-title":"Reprod Fertil Dev"},{"key":"36474_CR10","doi-asserted-by":"publisher","unstructured":"Cverenk\u00e1rov\u00e1 K, Valachovi\u02c7 cov\u00e1 M, Mackul\u2019ak T, \u017demli\u02c7 cka L, B\u00edro\u0161ov\u00e1 L (2021) Microplastics in the food chain. Life 11:1349. https:\/\/doi.org\/10.3390\/life11121349","DOI":"10.3390\/life11121349"},{"key":"36474_CR11","doi-asserted-by":"publisher","first-page":"46687","DOI":"10.1038\/srep46687","volume":"7","author":"Y Deng","year":"2017","unstructured":"Deng Y, Zhang Y, Lemos B, Ren H (2017) Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure. Sci Rep 7:46687. https:\/\/doi.org\/10.1038\/srep46687","journal-title":"Sci Rep"},{"key":"36474_CR12","doi-asserted-by":"publisher","first-page":"1481014","DOI":"10.3389\/fendo.2024.1481014","volume":"15","author":"AKA de Sousa","year":"2024","unstructured":"de Sousa AKA, Pires KSN, Cavalcante IH, Cavalcante ICL, Santos JD, Queiroz MIC, Leite ACR, Crispim AC, da Rocha Junior ER, Aquino TM, Weingrill RB, Urschitz J, Ospina-Prieto S, Borbely AU (2024) Polystyrene microplastics exposition on human placental explants induces timedependent cytotoxicity, oxidative stress and metabolic alterations. Front Endocrinol 15:1481014. https:\/\/doi.org\/10.3389\/fendo.2024.1481014","journal-title":"Front Endocrinol"},{"key":"36474_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1293\/tox.2018-0042","volume":"32","author":"S Furukawa","year":"2019","unstructured":"Furukawa S, Tsuji N, Sugiyama A (2019) Morphology and physiology of rat placenta for toxicological evaluation. J Toxicol Pathol 32:1\u201317. https:\/\/doi.org\/10.1293\/tox.2018-0042","journal-title":"J Toxicol Pathol"},{"key":"36474_CR14","doi-asserted-by":"publisher","first-page":"3459434606","DOI":"10.1007\/s11356-021-18218-3","volume":"29","author":"A Haddadi","year":"2022","unstructured":"Haddadi A, Kessabi K, Boughammoura S, Ben Rhouma M, Mlouka R, Banni M, Messaoudi I (2022) Exposure to microplastics leads to a defective ovarian function and change in cytoskeleton protein expression in rat. ESPR 29:3459434606. https:\/\/doi.org\/10.1007\/s11356-021-18218-3","journal-title":"ESPR"},{"key":"36474_CR15","doi-asserted-by":"publisher","first-page":"112842","DOI":"10.1016\/j.marpolbul.2021.112842","volume":"172","author":"A Hayes","year":"2021","unstructured":"Hayes A, Kirkbride KP, Leterme SC (2021) Variation in polymer types and abundance of microplastics from two rivers and beaches in Adelaide. South Australia Mar Pollut Bull 172:112842. https:\/\/doi.org\/10.1016\/j.marpolbul.2021.112842","journal-title":"South Australia Mar Pollut Bull"},{"key":"36474_CR16","doi-asserted-by":"publisher","unstructured":"Horvatits T, Tamminga M, Liu B, Sebode M, Carambia A, Fischer L, P\u00fcschel K, Huber S, Fischer EK (2022) Microplastics detected in cirrhotic liver tissue. EBioMedicine 82. https:\/\/doi.org\/10.1016\/j.ebiom.2022.104147","DOI":"10.1016\/j.ebiom.2022.104147"},{"key":"36474_CR17","doi-asserted-by":"publisher","first-page":"119924","DOI":"10.1016\/j.envpol.2022.119924","volume":"311","author":"J Hu","year":"2022","unstructured":"Hu J, Zhu Y, Zhang J, Xu Y, Wu J, Zeng W (2022) The potential toxicity of polystyrene nanoplastics to human trophoblasts in vitro. Environ Pollut 311:119924. https:\/\/doi.org\/10.1016\/j.envpol.2022.119924","journal-title":"Environ Pollut"},{"key":"36474_CR18","doi-asserted-by":"publisher","first-page":"6123","DOI":"10.1007\/s11033-013-2724-y","volume":"40","author":"YJ Hu","year":"2013","unstructured":"Hu YJ, Wang YD, Tan FQ, Yang WX (2013) Regulation of paracellular permeability: factors and mechanisms. Mol Biol Rep 40:6123\u20136142. https:\/\/doi.org\/10.1007\/s11033-013-2724-y","journal-title":"Mol Biol Rep"},{"key":"36474_CR19","doi-asserted-by":"publisher","first-page":"124399","DOI":"10.1016\/j.jhazmat.2020.124399","volume":"407","author":"D Huang","year":"2021","unstructured":"Huang D, Tao J, Cheng M, Deng R, Chen S, Yin L, Li R (2021) Microplastics and nanoplastics in the environment: macroscopic transport and effects on creatures. J Hazard Mater 407:124399. https:\/\/doi.org\/10.1016\/j.jhazmat.2020.124399","journal-title":"J Hazard Mater"},{"key":"36474_CR20","doi-asserted-by":"publisher","first-page":"154907","DOI":"10.1016\/j.scitotenv.2022.154907","volume":"831","author":"LC Jenner","year":"2022","unstructured":"Jenner LC, Rotchell JM, Bennett RT, Cowen M, Tentzeris V, Sadofsky LR (2022) Detection of microplastics in human lung tissue using \u03bcFTIR spectroscopy. Sci Total Environ 831:154907. https:\/\/doi.org\/10.1016\/j.scitotenv.2022.154907","journal-title":"Sci Total Environ"},{"key":"36474_CR21","doi-asserted-by":"publisher","first-page":"127815","DOI":"10.1016\/j.jhazmat.2021.127815","volume":"426","author":"B Jeong","year":"2022","unstructured":"Jeong B, Baek JY, Koo J, Park S, Ryu YK, Kim KS, Zhang S, Chung CH, Dogan R, Choi HS (2022) Maternal exposure to polystyrene nanoplastics causes brain abnormalities in progeny. J Hazard Mater 426:127815. https:\/\/doi.org\/10.1016\/j.jhazmat.2021.127815","journal-title":"J Hazard Mater"},{"key":"36474_CR22","doi-asserted-by":"publisher","unstructured":"Kelley LK, Smith CH, King BF (1983) Isolation and partial characterization of the basal cell membrane of human placental trophoblast. Biochim Biophys Acta 734:91\u201398. https:\/\/doi.org\/10.1016\/0005-2736(83)90079-2","DOI":"10.1016\/0005-2736(83)90079-2"},{"key":"36474_CR23","doi-asserted-by":"publisher","first-page":"107199","DOI":"10.1016\/j.envint.2022.107199","volume":"163","author":"HA Leslie","year":"2022","unstructured":"Leslie HA, Van Velzen MJ, Brandsma SH, Vethaak AD, Garcia Vallejo JJ, Lamoree MH (2022) Discovery and quantification of plastic particle pollution in human blood. Environ Int 163:107199. https:\/\/doi.org\/10.1016\/j.envint.2022.107199","journal-title":"Environ Int"},{"key":"36474_CR24","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1021\/envhealth.3c00052","volume":"1","author":"Y Li","year":"2023","unstructured":"Li Y, Tao L, Wang Q, Wang F, Li G, Song M (2023) Potential health impact of microplastics: a review of environmental distribution, human exposure, and toxic effects. Environ Health 1:249\u2013257. https:\/\/doi.org\/10.1021\/envhealth.3c00052","journal-title":"Environ Health"},{"issue":"1","key":"36474_CR25","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s12989-021-00414-1","volume":"18","author":"B Liang","year":"2021","unstructured":"Liang B, Zhong Y, Huang Y, Lin X, Liu J, Lin L, Hu M, Jiang J, Dai M, Wang B, Zhang B, Meng H, Justin J, Lelaka J, Sui H, Yang X, Huang Z (2021) Underestimated health risks: polystyrene micro- and nanoplastics jointly induce intestinal barrier dysfunction by ROS-mediated epithelial cell apoptosis. Part Fibre Toxicol 18(1):20. https:\/\/doi.org\/10.1186\/s12989-021-00414-1","journal-title":"Part Fibre Toxicol"},{"key":"36474_CR26","doi-asserted-by":"publisher","unstructured":"Li\u00e9vano S, Alarc\u00f3n L, Ch\u00e1vez\u2013Mungu\u00eda B, Gonz\u00e1lez\u2013Mariscal L (2006) Endothelia of term human placentae display diminished expression of tight junction proteins during preeclampsia. Cell Tissue Res 324:433\u2013448. https:\/\/doi.org\/10.1007\/s00441-005-0135-7","DOI":"10.1007\/s00441-005-0135-7"},{"key":"36474_CR27","doi-asserted-by":"publisher","first-page":"10978","DOI":"10.1021\/acs.est.9b03191","volume":"53","author":"T Luo","year":"2019","unstructured":"Luo T, Wang C, Pan Z, Jin C, Fu Z, Jin Y (2019) Maternal polystyrene microplastic exposure during gestation and lactation altered metabolic homeostasis in the dams and their F1 and F2 offspring. Environ Sci Technol 53:10978\u201310992. https:\/\/doi.org\/10.1021\/acs.est.9b03191","journal-title":"Environ Sci Technol"},{"key":"36474_CR28","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","volume":"47","author":"S Marklund","year":"1974","unstructured":"Marklund S, Marklund G (1974) Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 47:469\u2013474. https:\/\/doi.org\/10.1111\/j.1432-1033.1974.tb03714.x","journal-title":"Eur J Biochem"},{"key":"36474_CR29","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/BF00317652","volume":"159","author":"J Metz","year":"1980","unstructured":"Metz J (1980) On the developing rat placenta I: Differentiation and junctional alterations of labyrinthine layers II and III. Anat Embryol 159:289\u2013305. https:\/\/doi.org\/10.1007\/BF00317652","journal-title":"Anat Embryol"},{"key":"36474_CR30","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.3390\/cells8101174","volume":"8","author":"J Miranda","year":"2019","unstructured":"Miranda J, Mart\u00edn-Tapia D, Valdespino-V\u00e1zquez Y, Alarc\u00f3n L, Espejel-Nu\u00f1ez A, Guzm\u00e1n-Huerta M, Mu\u00f1oz-Medina JE, Shibayama M, Ch\u00e1vez-Mungu\u00eda B, Estrada-Guti\u00e9rrez G, Lievano S, Ludert EL, Gonz\u00e1lez-Mariscal L (2019) Syncytiotrophoblast of placentae from women with Zika virus infection has altered tight junction protein expression and increased paracellular permeability. Cells 8:1174. https:\/\/doi.org\/10.3390\/cells8101174","journal-title":"Cells"},{"key":"36474_CR31","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1517\/17425255.3.3.331","volume":"3","author":"P Myllynen","year":"2007","unstructured":"Myllynen P, Pasanen M, V\u00e4h\u00e4kangas K (2007) The fate and effects of xenobiotics in human placenta. Expert Opin Drug Metab Toxicol 3:331\u2013346. https:\/\/doi.org\/10.1517\/17425255.3.3.331","journal-title":"Expert Opin Drug Metab Toxicol"},{"issue":"2","key":"36474_CR32","doi-asserted-by":"publisher","first-page":"27","DOI":"10.4103\/0976-0105.177703","volume":"7","author":"AB Nair","year":"2016","unstructured":"Nair AB, Jacob S (2016) A simple practice guide for dose conversion between animals and human. J Basic Clin Pharm 7(2):27\u201331. https:\/\/doi.org\/10.4103\/0976-0105.177703","journal-title":"J Basic Clin Pharm"},{"key":"36474_CR33","doi-asserted-by":"publisher","first-page":"106274","DOI":"10.1016\/j.envint.2020.106274","volume":"146","author":"A Ragusa","year":"2021","unstructured":"Ragusa A, Svelato A, Santacroce C, Catalano P, Notarstefano V, Carnevali O, Papa F, Ciro M, Rongioletti A, Baiocco F, Draghi S, D\u2019Amore E, Rinaldo D, Matta M, Giorgini E (2021) Plasticenta: first evidence of microplastics in human placenta. Environ Int 146:106274. https:\/\/doi.org\/10.1016\/j.envint.2020.106274","journal-title":"Environ Int"},{"key":"36474_CR34","doi-asserted-by":"publisher","first-page":"165e81","DOI":"10.1242\/dev.113.1.165","volume":"113","author":"B Risek","year":"1991","unstructured":"Risek B, Gilula NB (1991) Spatiotemporal expression of three gap junction gene products involved in fetomaternal communication during rat pregnancy. Development 113:165e81. https:\/\/doi.org\/10.1242\/dev.113.1.165","journal-title":"Development"},{"key":"36474_CR35","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1039\/d1va00012h","volume":"1","author":"P Roy","year":"2022","unstructured":"Roy P, Mohanty AK, Misra M (2022) Microplastics in ecosystems: their implications and mitigation pathways. Environ Sci Adv 1:9. https:\/\/doi.org\/10.1039\/d1va00012h","journal-title":"Environ Sci Adv"},{"key":"36474_CR36","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/0003-2697(68)90092-4","volume":"25","author":"J Sedlak","year":"1968","unstructured":"Sedlak J, Lindsay RH (1968) Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman\u2019s reagent. Anal Biochem 25:192\u2013205. https:\/\/doi.org\/10.1016\/0003-2697(68)90092-4","journal-title":"Anal Biochem"},{"key":"36474_CR37","doi-asserted-by":"publisher","first-page":"124004","DOI":"10.1016\/j.jhazmat.2020.124004","volume":"15","author":"K Senathirajah","year":"2020","unstructured":"Senathirajah K, Attwood S, Bhagwat G, Carbery M, Wilson S, Palanisami T (2020) Estimation of the mass of microplastics ingested - a pivotal first step towards human health risk assessment. J Hazard Mater 15:124004. https:\/\/doi.org\/10.1016\/j.jhazmat.2020.124004","journal-title":"J Hazard Mater"},{"key":"36474_CR38","doi-asserted-by":"publisher","first-page":"118960","DOI":"10.1016\/j.watres.2022.118960","volume":"223","author":"F Shen","year":"2022","unstructured":"Shen F, Li D, Guo J, Chen J (2022) Mechanistic toxicity assessment of differently sized and charged polystyrene nanoparticles based on human placental cells. Water Res 223:118960. https:\/\/doi.org\/10.1016\/j.watres.2022.118960","journal-title":"Water Res"},{"key":"36474_CR39","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1053\/plac.2002.0790","volume":"23","author":"P Sibley","year":"2002","unstructured":"Sibley P, Glazier D, Greenwood L, Lacey H, Mynett K, Speake P, Powell L (2002) Regulation of placental transfer: the Na+\/H+ exchanger\u2014a review. Placenta 23:39\u201346. https:\/\/doi.org\/10.1053\/plac.2002.0790","journal-title":"Placenta"},{"key":"36474_CR40","doi-asserted-by":"publisher","first-page":"164531","DOI":"10.1016\/j.scitotenv.2023.164531","volume":"892","author":"SA Siddiqui","year":"2023","unstructured":"Siddiqui SA, Singh S, Bahmidd NA, Douglas DJH, Shyuf DR, Lorenzog JM, Pereira JAM, C\u00e2mara JS (2023) Polystyrene microplastic particles in the food chain: characteristics and toxicity- a review. Sci Total Environ 892:164531. https:\/\/doi.org\/10.1016\/j.scitotenv.2023.164531","journal-title":"Sci Total Environ"},{"issue":"3","key":"36474_CR41","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1152\/physrev.1997.77.3.805","volume":"77","author":"J Stulk","year":"1997","unstructured":"Stulk J (1997) Placental transfer of inorganic ions and water. Physiol Rev 77(3):805\u2013836. https:\/\/doi.org\/10.1152\/physrev.1997.77.3.805","journal-title":"Physiol Rev"},{"key":"36474_CR42","doi-asserted-by":"publisher","first-page":"487","DOI":"10.2165\/00003088-200443080-00001","volume":"43","author":"MR Syme","year":"2004","unstructured":"Syme MR, Paxton JW, Keelan JA (2004) Drug transfer and metabolism by the human placenta. Clin Pharmacokinet 43:487\u2013514. https:\/\/doi.org\/10.2165\/00003088-200443080-00001","journal-title":"Clin Pharmacokinet"},{"key":"36474_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1262\/jrd.43.13","volume":"43","author":"K Takata","year":"1997","unstructured":"Takata K, Fujikura K, Shin BC (1997) Ultrastructure of the rodent placental labyrinth: a site of barrier transport. J Reprod Devel 43:1. https:\/\/doi.org\/10.1262\/jrd.43.13","journal-title":"J Reprod Devel"},{"key":"36474_CR44","doi-asserted-by":"publisher","first-page":"109956","DOI":"10.1016\/j.ecoenv.2019.109956","volume":"189","author":"C Teng","year":"2020","unstructured":"Teng C, Jia J, Wang Z, Yan B (2020) Oral co-exposures to zinc oxide nanoparticles and CdCl2 induced maternal-fetal pollutant transfer and embryotoxicity by damaging placental barriers. Ecotoxicol Environ Saf 189:109956. https:\/\/doi.org\/10.1016\/j.ecoenv.2019.109956","journal-title":"Ecotoxicol Environ Saf"},{"issue":"1","key":"36474_CR45","doi-asserted-by":"publisher","first-page":"133","DOI":"10.3390\/ani11010133","volume":"11","author":"M Venditti","year":"2021","unstructured":"Venditti M, Romano MZ, Aniello F, Minucci S (2021) Preliminary investigation on the ameliorative role exerted by D-aspartic acid in counteracting ethane dimethane sulfonate (EDS) toxicity in the rat testis. Animals (Basel) 11(1):133. https:\/\/doi.org\/10.3390\/ani11010133","journal-title":"Animals (Basel)"},{"key":"36474_CR46","doi-asserted-by":"publisher","first-page":"1145702","DOI":"10.3389\/fcell.2023.1145702","volume":"11","author":"M Venditti","year":"2023","unstructured":"Venditti M, Ben Hadj Hassine M, Messaoudi I, Minucci S (2023) The simultaneous administration of microplastics and cadmium alters rat testicular activity and changes the expression of PTMA, DAAM1 and PREP. Front Cell Dev Biol 11:1145702. https:\/\/doi.org\/10.3389\/fcell.2023.1145702","journal-title":"Front Cell Dev Biol"},{"issue":"1","key":"36474_CR47","doi-asserted-by":"publisher","first-page":"113735","DOI":"10.1016\/j.envres.2022.113735","volume":"214","author":"H Yadav","year":"2022","unstructured":"Yadav H, Sethulekshmi S, Shriwastav A (2022) Estimation of microplastic exposure via the composite sampling of drinking water, respirable air, and cooked food from Mumbai. India Environ Res 214(1):113735. https:\/\/doi.org\/10.1016\/j.envres.2022.113735","journal-title":"India Environ Res"},{"key":"36474_CR48","first-page":"89","volume":"8","author":"F Zamora","year":"1987","unstructured":"Zamora F, Arola LI (1987) (Na\u2019-K\u2019)-ATPase activities in rat tissues during pregnancy. Biol Res Pregnancy 8:89\u201392","journal-title":"Biol Res Pregnancy"},{"key":"36474_CR49","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.placenta.2010.01.005","volume":"31","author":"Y Zhang","year":"2010","unstructured":"Zhang Y, Cui Y, Zhou Z, Sha J, Li Y, Liu J (2010) Altered global gene expressions of human placentae subjected to assisted reproductive technology treatments. Placenta 31:251\u2013258. https:\/\/doi.org\/10.1016\/j.placenta.2010.01.005","journal-title":"Placenta"},{"key":"36474_CR50","doi-asserted-by":"publisher","unstructured":"Zhao H, Hundal HS (2000) Identification and biochemical localization of a Na-K-Cl cotransporter in the human placental cell line BeWo. Biochem Biophys Res Commun 21: 274(1):43\u201348. https:\/\/doi.org\/10.1006\/bbrc.2000.3099","DOI":"10.1006\/bbrc.2000.3099"},{"issue":"1","key":"36474_CR51","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1093\/biolre\/ioac186","volume":"108","author":"Y Zhao","year":"2023","unstructured":"Zhao Y, Pasanen M, Rys\u00e4 J (2023) Placental ion channels: potential target of chemical exposure. Biol Reprod 108(1):41\u201351. https:\/\/doi.org\/10.1093\/biolre\/ioac186","journal-title":"Biol Reprod"},{"key":"36474_CR52","doi-asserted-by":"publisher","first-page":"1330396","DOI":"10.3389\/fendo.2023.1330396","volume":"14","author":"RE Zurub","year":"2024","unstructured":"Zurub RE, Cariaco Y, Wade MG, Bainbridge SA (2024) Microplastics exposure: implications for human fertility, pregnancy and child health. Front Endocrinol 14:1330396. https:\/\/doi.org\/10.3389\/fendo.2023.1330396","journal-title":"Front Endocrinol"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-025-36474-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11356-025-36474-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-025-36474-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:25:36Z","timestamp":1750897536000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11356-025-36474-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,30]]},"references-count":52,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2025,5]]}},"alternative-id":["36474"],"URL":"https:\/\/doi.org\/10.1007\/s11356-025-36474-5","relation":{},"ISSN":["1614-7499"],"issn-type":[{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,30]]},"assertion":[{"value":"7 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experiments and procedures involving Wistar rats were conducted in accordance with Directive 609\/86 of the Ethics and Confidentiality Committee (EEC) concerning the welfare of experimental animals. The study also adhered to the ethical guidelines approved by the local ethics committee at the Institute of Biotechnology, University of Monastir, under reference number EEA B-35\u2013072 CER-VS\/ISBM022\/2023.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}}]}}