{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T14:28:02Z","timestamp":1773239282731,"version":"3.50.1"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2011,7,7]],"date-time":"2011-07-07T00:00:00Z","timestamp":1309996800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AGE"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1007\/s11357-011-9280-y","type":"journal-article","created":{"date-parts":[[2011,7,6]],"date-time":"2011-07-06T03:44:46Z","timestamp":1309923886000},"page":"795-804","source":"Crossref","is-referenced-by-count":15,"title":["Telomere length dynamics in the human pituitary gland: robust preservation throughout adult life to centenarian age"],"prefix":"10.1007","volume":"34","author":[{"given":"Naoshi","family":"Ishikawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken-Ichi","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naotaka","family":"Izumiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Aida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoji","family":"Sawabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomio","family":"Arai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kishimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mutsunori","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akio","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaiyo","family":"Takubo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,7,7]]},"reference":[{"key":"9280_CR1","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.ejca.2009.10.018","volume":"46","author":"J Aida","year":"2010","unstructured":"Aida J, Izumo T, Shimomura N, Nakamura K, Ishikawa N, Matsuura M, Poon SS, Fujiwara M, Sawabe M, Arai T, Takubo K (2010) Telomere lengths in the oral epithelia with and without carcinoma. Eur J Cancer 46:430\u2013438","journal-title":"Eur J Cancer"},{"key":"9280_CR2","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1002\/path.2817","volume":"223","author":"J Aida","year":"2011","unstructured":"Aida J, Yokoyama A, Izumiyama N, Nakamura K, Ishikawa N, Poon SSS, Fujiwara M, Sawabe M, Matsuura M, Arai T, Takubo K (2011) Alcoholics show reduced telomere length in the oesophagus. J Pathol 223:410\u2013416","journal-title":"J Pathol"},{"key":"9280_CR3","doi-asserted-by":"publisher","first-page":"10114","DOI":"10.1073\/pnas.89.21.10114","volume":"89","author":"RC Allsopp","year":"1992","unstructured":"Allsopp RC, Vaziri H, Patterson C, Goldstein S, Younglai EV, Futcher AB, Greider CW, Harley CB (1992) Telomere length predicts replicative capacity of human fibroblasts. Proc Natl Acad Sci USA 89:10114\u201310118","journal-title":"Proc Natl Acad Sci USA"},{"key":"9280_CR4","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/ng1084","volume":"33","author":"DM Baird","year":"2003","unstructured":"Baird DM, Rowson J, Wynford-Thomas D, Kipling D (2003) Extensive allelic variation and ultrashort telomeres in senescent human cells. Nat Genet 33:203\u2013207","journal-title":"Nat Genet"},{"key":"9280_CR5","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1111\/j.1474-9726.2006.00254.x","volume":"6","author":"GM Bearlocher","year":"2007","unstructured":"Bearlocher GM, Rice K, Vulto I, Lansdorp PM (2007) Longitudinal data on telomere length in leukocytes from newborn baboons support a marked drop in stem cell turnover around 1\u00a0year of age. Aging Cell 6:121\u2013123","journal-title":"Aging Cell"},{"key":"9280_CR6","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1038\/350569a0","volume":"350","author":"EH Blackburn","year":"1991","unstructured":"Blackburn EH (1991) Structure and function of telomeres. Nature 350:569\u2013573","journal-title":"Nature"},{"key":"9280_CR7","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/S0140-6736(03)12384-7","volume":"361","author":"RM Cawthon","year":"2003","unstructured":"Cawthon RM, Smith KR, O\u2019Brien E, Sivatchenko A, Kerber RA (2003) Association between telomere length in blood and mortality in people aged 60\u00a0years or older. Lancet 361:393\u2013395","journal-title":"Lancet"},{"key":"9280_CR8","doi-asserted-by":"publisher","first-page":"17312","DOI":"10.1073\/pnas.0407162101","volume":"101","author":"ES Epel","year":"2004","unstructured":"Epel ES, Blackburn EH, Lin J, Dhabhar FS, Adler NE, Morrow JD, Cawthon RM (2004) Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci USA 101:17312\u201317315","journal-title":"Proc Natl Acad Sci USA"},{"key":"9280_CR9","doi-asserted-by":"publisher","first-page":"5607","DOI":"10.1073\/pnas.95.10.5607","volume":"95","author":"RW Frenck Jr","year":"1998","unstructured":"Frenck RW Jr, Blackburn EH, Shannon KM (1998) The rate of telomere sequence loss in human leukocytes varies with age. Proc Natl Acad Sci USA 95:5607\u20135610","journal-title":"Proc Natl Acad Sci USA"},{"key":"9280_CR10","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/S0047-6374(00)00173-1","volume":"119","author":"U Friedrich","year":"2000","unstructured":"Friedrich U, Griese E-U, Schwab M, Fritz P, Thon K-P, Klotz U (2000) Telomere length in different tissues of elderly patients. Mech Ageing Dev 119:89\u201399","journal-title":"Mech Ageing Dev"},{"key":"9280_CR11","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.2144\/01316bc02","volume":"31","author":"JD Grant","year":"2001","unstructured":"Grant JD, Broccoli D, Muquit M, Manion FJ, Tisdall J, Ochs MF (2001) Telometric: a tool providing simplified, reproducible measurements of telomeric DNA from constant field agarose gels. Biotechniques 31:1314\u20131316","journal-title":"Biotechniques"},{"key":"9280_CR12","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1146\/annurev.bi.65.070196.002005","volume":"65","author":"CW Greider","year":"1996","unstructured":"Greider CW (1996) Telomere length regulation. Annu Rev Biochem 65:337\u2013365","journal-title":"Annu Rev Biochem"},{"key":"9280_CR13","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/345458a0","volume":"345","author":"CB Harley","year":"1990","unstructured":"Harley CB, Futcher AB, Greider CW (1990) Telomeres shorten during ageing of human fibroblasts. Nature 345:458\u2013460","journal-title":"Nature"},{"key":"9280_CR14","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1038\/346866a0","volume":"346","author":"ND Hastie","year":"1990","unstructured":"Hastie ND, Dempster M, Dunlop MG, Thompson AM, Green DK, Allshire RC (1990) Telomere reduction in human colorectal carcinoma and with ageing. Nature 346:866\u2013868","journal-title":"Nature"},{"key":"9280_CR15","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1016\/j.exger.2006.06.036","volume":"41","author":"A Ishii","year":"2006","unstructured":"Ishii A, Nakamura K, Kishimoto H, Honma N, Aida J, Sawabe M, Arai T, Fujiwara M, Takeuchi F, Kato M, Oshimura M, Izumiyama N, Takubo K (2006) Telomere shortening with aging in the human pancreas. Exp Gerontol 41:882\u2013886","journal-title":"Exp Gerontol"},{"key":"9280_CR16","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.mad.2007.10.009","volume":"129","author":"D Kappei","year":"2007","unstructured":"Kappei D, Londo\u00f1o-Vallejo A (2007) Telomere length inheritance and aging. Mech Ageing Dev 129:17\u201326","journal-title":"Mech Ageing Dev"},{"key":"9280_CR17","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1016\/0022-2836(92)90096-3","volume":"225","author":"MZ Levy","year":"1992","unstructured":"Levy MZ, Allsopp RC, Futcher AB, Greider CW, Harley CB (1992) Telomere end-replication problem and cell aging. J Mol Biol 225:951\u2013960","journal-title":"J Mol Biol"},{"key":"9280_CR18","first-page":"321","volume-title":"Histology for pathologists","author":"MBS Lopes","year":"2007","unstructured":"Lopes MBS, Pernicone PJ, Scheithauer BW, Horvath E, Kovacs K (2007) Pituitary and sellar region. In: Mills SE (ed) Histology for pathologists, 3rd edn. Lippincott Williams & Wilkins, Philadelphia, pp 321\u2013344","edition":"3"},{"key":"9280_CR19","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1046\/j.1523-1747.2002.19523.x","volume":"119","author":"K Nakamura","year":"2002","unstructured":"Nakamura K, Izumiyama-Shimomura N, Sawabe M, Arai T, Aoyagi Y, Fujiwara M, Tsuchiya E, Kobayashi Y, Kato M, Oshimura M, Sasajima K, Nakachi K, Takubo K (2002) Comparative analysis of telomere lengths and erosion with age in human epidermis and lingual epithelium. J Invest Dermatol 119:1014\u20131019","journal-title":"J Invest Dermatol"},{"key":"9280_CR20","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1016\/j.exger.2007.05.003","volume":"42","author":"K Nakamura","year":"2007","unstructured":"Nakamura K, Takubo K, Izumiyama-Shimomura N, Sawabe M, Arai T, Kishimoto H, Fujiwara M, Kato M, Oshimura M, Ishii A, Ishikawa N (2007) Telomeric DNA length in cerebral gray and white matter is associated with longevity in individuals aged 70\u00a0years or older. Exp Gerontol 42:944\u2013950","journal-title":"Exp Gerontol"},{"key":"9280_CR21","first-page":"1496","volume":"201","author":"AM Olovnikov","year":"1971","unstructured":"Olovnikov AM (1971) Principles of marginotomy in template synthesis of polynucleotides. Doklady Akad Nauk USSR 201:1496\u20131499","journal-title":"Doklady Akad Nauk USSR"},{"key":"9280_CR22","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/0531-5565(96)00005-8","volume":"31","author":"AM Olovnikov","year":"1996","unstructured":"Olovnikov AM (1996) Telomeres, telomerase, and aging: origin of the theory. Exp Gerontol 31:443\u2013448","journal-title":"Exp Gerontol"},{"key":"9280_CR23","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1111\/j.1440-1827.2006.01966.x","volume":"56","author":"M Sawabe","year":"2006","unstructured":"Sawabe M, Saito M, Naka M, Kasahara I, Saito Y, Arai T, Hamamatsu A, Shirasawa T (2006) Standard organ weights among elderly Japanese who died in hospital, including 50 centenarians. Pathol Int 56:315\u2013323","journal-title":"Pathol Int"},{"key":"9280_CR24","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1111\/j.1749-6632.2002.tb02079.x","volume":"959","author":"G Saretzki","year":"2002","unstructured":"Saretzki G, von Zglinicki T (2002) Replicative aging, telomeres, and oxidative stress. Ann N Y Acad Sci 959:24\u201329","journal-title":"Ann N Y Acad Sci"},{"key":"9280_CR25","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/0092-8674(84)90301-5","volume":"37","author":"DC Schwartz","year":"1984","unstructured":"Schwartz DC, Cantor CR (1984) Separation of yeast chromosome-sized DNAs by pulsed field gradient gel electrophoresis. Cell 37:67\u201375","journal-title":"Cell"},{"key":"9280_CR26","unstructured":"Statistics and Information Department, Ministry\u2019s Secretariat, Ministry of Health, Labour and Welfare Japan (ed) (2006) Statistical abstracts of health and welfare in Japan 2005. Health & Statistics Association Japan"},{"key":"9280_CR27","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/s11357-999-0011-6","volume":"22","author":"K Takubo","year":"1999","unstructured":"Takubo K, Nakamura K, Izumiyama N, Sawabe M, Arai T, Esaki Y, Tanaka Y, Mafune K, Fujiwara M, Kammori M, Sasajima K (1999) Telomere shortening with aging in human esophageal mucosa. Age 22:95\u201399","journal-title":"Age"},{"key":"9280_CR28","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/S0531-5565(01)00218-2","volume":"37","author":"K Takubo","year":"2002","unstructured":"Takubo K, Izumiyama-Shimomura N, Honma N, Sawabe M, Arai T, Kato M, Oshimura M, Nakamura K (2002) Telomere lengths are characteristic in each human individual. Exp Gerontol 37:523\u2013531","journal-title":"Exp Gerontol"},{"key":"9280_CR29","first-page":"661","volume":"52","author":"H Vaziri","year":"1993","unstructured":"Vaziri H, Schachter F, Uchida I, Wei L, Zhu X, Effros R, Cohen D, Harley CB (1993) Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes. Am J Hum Genet 52:661\u2013667","journal-title":"Am J Hum Genet"},{"key":"9280_CR30","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1038\/nature05976","volume":"447","author":"RE Verdun","year":"2007","unstructured":"Verdun RE, Karlseder J (2007) Replication and protection of telomeres. Nature 447:924\u2013931","journal-title":"Nature"},{"key":"9280_CR31","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1006\/excr.1995.1305","volume":"220","author":"T Zglinicki von","year":"1995","unstructured":"von Zglinicki T, Saretzki G, D\u00f6cke W, Lotze C (1995) Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence? Exp Cell Res 220:186\u2013193","journal-title":"Exp Cell Res"},{"key":"9280_CR32","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/239197a0","volume":"239","author":"J Watson","year":"1972","unstructured":"Watson J (1972) Origin of concatemeric T7 DNA. Nat N Biol 239:197\u2013201","journal-title":"Nat N Biol"}],"container-title":["AGE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11357-011-9280-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11357-011-9280-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.springerlink.com\/index\/pdf\/10.1007\/s11357-011-9280-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11357-011-9280-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T00:08:10Z","timestamp":1548202090000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11357-011-9280-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,7]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["9280"],"URL":"https:\/\/doi.org\/10.1007\/s11357-011-9280-y","relation":{},"ISSN":["0161-9152","1574-4647"],"issn-type":[{"value":"0161-9152","type":"print"},{"value":"1574-4647","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,7]]}}}