{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:15:40Z","timestamp":1791605740036,"version":"4.3.4"},"reference-count":79,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2011,9,6]],"date-time":"2011-09-06T00:00:00Z","timestamp":1315267200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AGE"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1007\/s11357-011-9293-6","type":"journal-article","created":{"date-parts":[[2011,9,6]],"date-time":"2011-09-06T17:28:24Z","timestamp":1315330104000},"page":"935-947","source":"Crossref","is-referenced-by-count":40,"title":["Instability of the cellular lipidome with age"],"prefix":"10.1007","volume":"34","author":[{"given":"Jessica R.","family":"Hughes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane M.","family":"Deeley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Blanksby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich","family":"Leisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shane R.","family":"Ellis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger J. W.","family":"Truscott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd W.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,9,6]]},"reference":[{"issue":"7","key":"9293_CR1","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/BF02535072","volume":"24","author":"K Anders","year":"1989","unstructured":"Anders K, Appelkvist EL, Dallner G (1989) Age-related changes in the lipid compositions of rat and human tissues. Lipids 24(7):579\u2013584","journal-title":"Lipids"},{"issue":"1","key":"9293_CR2","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0304-4165(02)00271-4","volume":"1572","author":"J Arnhold","year":"2002","unstructured":"Arnhold J, Osipov AN, Spalteholz H, Panasenko OM, Schiller J (2002) Formation of lysophospholipids from unsaturated phosphatidylcholines under the influence of hypochlorous acid. Biochimica et Biophysica Acta 1572(1):91\u2013100","journal-title":"Biochimica et Biophysica Acta"},{"issue":"6","key":"9293_CR3","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1076\/ceyr.19.6.506.5279","volume":"19","author":"V Bantseev","year":"1999","unstructured":"Bantseev V, Herbert KL, Trevithick JR, Sivak JG (1999) Mitochondria of rat lenses: distribution near and at the sutures. Curr Eye Res 19(6):506\u2013516","journal-title":"Curr Eye Res"},{"issue":"5923","key":"9293_CR4","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1126\/science.1164680","volume":"324","author":"O Bergmann","year":"2009","unstructured":"Bergmann O, Bhardwaj RD, Bernard S, Zdunek S, Barnabe-Heider F, Walsh S, Zupicich J, Alkass K, Buchholz BA, Druid H, Jovinge S, Frisen J (2009) Evidence for cardiomyocyte renewal in humans. Science 324(5923):98\u2013102","journal-title":"Science"},{"issue":"33","key":"9293_CR5","doi-asserted-by":"crossref","first-page":"12564","DOI":"10.1073\/pnas.0605177103","volume":"103","author":"RD Bhardwaj","year":"2006","unstructured":"Bhardwaj RD, Curtis MA, Spalding KL, Buchholz BA, Fink D, Bjork-Eriksson T, Nordborg C, Gage FH, Druid H, Eriksson PS, Frisen J (2006) Neocortical neurogenesis in humans is restricted to development. Proc Natl Acad Sci U S A 103(33):12564\u201312568","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"9293_CR6","first-page":"1053","volume":"39","author":"D Borchman","year":"1998","unstructured":"Borchman D, Yappert MC (1998) Age-related lipid oxidation in human lenses. Investig Ophthalmol Vis Sci 39(6):1053\u20131058","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"11","key":"9293_CR7","first-page":"3938","volume":"35","author":"D Borchman","year":"1994","unstructured":"Borchman D, Byrdwell WC, Yappert MC (1994) Regional and age-dependent differences in the phospholipid composition of human lens membranes. Investig Ophthalmol Vis Sci 35(11):3938\u20133942","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"3","key":"9293_CR8","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/(SICI)1520-6343(1999)5:3<151::AID-BSPY5>3.0.CO;2-D","volume":"5","author":"D Borchman","year":"1999","unstructured":"Borchman D, Tang D, Yappert MC (1999) Lipid composition, membrane structure relationships in lens and muscle sarcoplasmic reticulum membranes. Biospectroscopy 5(3):151\u2013167","journal-title":"Biospectroscopy"},{"key":"9293_CR9","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0021-9258(19)63319-3","volume":"236","author":"LF Borkenhagen","year":"1961","unstructured":"Borkenhagen LF, Kennedy EP, Fielding L (1961) Enzymatic formation and decarboxylation of phosphatidylserine. J Biol Chem 236:28\u201330","journal-title":"J Biol Chem"},{"issue":"3","key":"9293_CR10","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/0005-2760(69)90009-5","volume":"187","author":"R Broekhuyse","year":"1969","unstructured":"Broekhuyse R (1969) Phospholipids in tissues of eye 3. Composition and metabolism of phospholipids in human lens in relation to age and cataract formation. Biochim Biophys Acta 187(3):354","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"9293_CR11","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0005-2760(78)90012-7","volume":"530","author":"E Cotlier","year":"1978","unstructured":"Cotlier E, Obara Y, Toftness B (1978) Cholesterol and phospholipids in protein fractions of human lens and senile cataract. Biochim Biophys Acta 530(2):267\u2013278","journal-title":"Biochim Biophys Acta"},{"issue":"6\u20137","key":"9293_CR12","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.bbalip.2008.04.002","volume":"1781","author":"JM Deeley","year":"2008","unstructured":"Deeley JM, Mitchell TW, Xiaojia W, Korth J, Nealon JR, Blanksby SJ, Truscott RJ (2008) Human lens lipids differ markedly from those of commonly used experimental animals. Biochim Biophys Acta 1781(6\u20137):288\u2013298","journal-title":"Biochim Biophys Acta"},{"issue":"5","key":"9293_CR13","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1021\/ac802395d","volume":"81","author":"JM Deeley","year":"2009","unstructured":"Deeley JM, Thomas MC, Truscott RJW, Mitchell TW, Blanksby SJ (2009) Identification of abundant alkyl ether glycerophospholipids in the human lens by tandem mass spectrometry techniques. Anal Chem 81(5):1920\u20131930","journal-title":"Anal Chem"},{"key":"9293_CR14","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1194\/jlr.M007716","volume":"51","author":"JM Deeley","year":"2010","unstructured":"Deeley JM, Hankin JA, Friedrich MG, Murphy RC, Truscott RJW, Mitchell TW, Blanksby SJ (2010) Sphingolipid distribution changes with age in the human lens. J Lipid Res 51:2753\u20132760","journal-title":"J Lipid Res"},{"key":"9293_CR15","unstructured":"R Development Core Team (2009) A language and environment for statistical computing. Vienna, Austria"},{"issue":"3","key":"9293_CR16","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0020-7292(01)00581-1","volume":"76","author":"G Dilmen","year":"2002","unstructured":"Dilmen G, K\u00f6ktener A, Turhan N\u00d6, Tez S (2002) Growth of the fetal lens and orbit. Int J Gynecol Obstet 76(3):267\u2013271","journal-title":"Int J Gynecol Obstet"},{"issue":"6","key":"9293_CR17","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0014-4835(81)80105-4","volume":"33","author":"A Dovrat","year":"1981","unstructured":"Dovrat A, Gershon D (1981) Rat lens superoxide dismutase and glucose-6-phosphate dehydrogenase: studies on the catalytic activity and the fate of enzyme antigen as a function of age. Exp Eye Res 33(6):651\u2013661","journal-title":"Exp Eye Res"},{"issue":"2\u20133","key":"9293_CR18","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0047-6374(84)90019-8","volume":"28","author":"A Dovrat","year":"1984","unstructured":"Dovrat A, Scharf J, Gershon D (1984) Glyceraldehyde 3-phosphate dehydrogenase activity in rat and human lenses and the fate of enzyme molecules in the aging lens. Mech Ageing Dev 28(2\u20133):187\u2013191","journal-title":"Mech Ageing Dev"},{"key":"9293_CR19","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/j.jasms.2010.09.003","volume":"21","author":"SR Ellis","year":"2010","unstructured":"Ellis SR, Wu C, Deeley JM, Zhu X, Truscott RJW, in het Panhuis M, Cooks RG, Mitchell TW, Blanksby SJ (2010) Imaging of human lens lipids by desorption electrospray ionization mass spectrometry. J Am Soc Mass Spectrom 21:2095\u20132104","journal-title":"J Am Soc Mass Spectrom"},{"issue":"3","key":"9293_CR20","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.bbamem.2009.11.008","volume":"1798","author":"R Estrada","year":"2010","unstructured":"Estrada R, Puppato A, Borchman D, Yappert MC (2010) Reevaluation of the phospholipid composition in membranes of adult human lenses by 31P NMR and MALDI MS. Biochim Biophys Acta 1798(3):303\u2013311","journal-title":"Biochim Biophys Acta"},{"key":"9293_CR21","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","volume":"226","author":"J Folch","year":"1957","unstructured":"Folch J, Lees M, Sloane Stanley GH (1957) A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226:497\u2013509","journal-title":"J Biol Chem"},{"issue":"10","key":"9293_CR22","doi-asserted-by":"crossref","first-page":"4786","DOI":"10.1167\/iovs.09-3588","volume":"50","author":"MG Friedrich","year":"2009","unstructured":"Friedrich MG, Truscott RJW (2009) Membrane association of proteins in the aging human lens: profound changes take place in the fifth decade of life. Investig Ophthalmol Vis Sci 50(10):4786\u20134793","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"3","key":"9293_CR23","doi-asserted-by":"crossref","first-page":"368","DOI":"10.2174\/1389557510909030368","volume":"9","author":"B Fuchs","year":"2009","unstructured":"Fuchs B, Schiller J (2009) Lysophospholipids: their generation, physiological role and detection. Are they important disease markers? Mini-Rev Med Chem 9(3):368\u2013378","journal-title":"Mini-Rev Med Chem"},{"issue":"2","key":"9293_CR24","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0042-6989(97)00102-8","volume":"38","author":"A Glasser","year":"1998","unstructured":"Glasser A, Campbell MCW (1998) Presbyopia and the optical changes in the human crystalline lens with age. Vis Res 38(2):209\u2013229","journal-title":"Vis Res"},{"issue":"2","key":"9293_CR25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00004397-200104000-00003","volume":"41","author":"A Glasser","year":"2001","unstructured":"Glasser A, Croft MA, Kaufman PL (2001) Aging of the human crystalline lens and presbyopia. Int Ophthalmol Clin 41(2):1\u201315","journal-title":"Int Ophthalmol Clin"},{"issue":"2","key":"9293_CR26","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.exer.2004.12.014","volume":"81","author":"V Grami","year":"2005","unstructured":"Grami V, Marrero Y, Huang L, Tang D, Yappert MC, Borchman D (2005) Alpha-crystallin binding in vitro to lipids from clear human lenses. Exp Eye Res 81(2):138\u2013146","journal-title":"Exp Eye Res"},{"issue":"21","key":"9293_CR27","doi-asserted-by":"crossref","first-page":"5793","DOI":"10.1093\/emboj\/19.21.5793","volume":"19","author":"S Grether-Beck","year":"2000","unstructured":"Grether-Beck S, Bonizzi G, Schmitt-Brenden H, Felsner I, Timmer A, Sies H, Johnson JP, Piette J, Krutmann J (2000) Non-enzymatic triggering of the ceramide signalling cascade by solar UVA radiation. EMBO J 19(21):5793\u20135800","journal-title":"EMBO J"},{"issue":"2","key":"9293_CR28","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1006\/abio.2001.5536","volume":"302","author":"X Han","year":"2002","unstructured":"Han X (2002) Characterisation and direct quantitation of ceramide molecular species from lipid extracts of biological samples by electrospray ionization tandem mass spectrometry. Anal Biochem 302(2):199\u2013212","journal-title":"Anal Biochem"},{"issue":"4","key":"9293_CR29","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1046\/j.1471-4159.2002.00997.x","volume":"82","author":"X Han","year":"2002","unstructured":"Han X, David MH, Daniel WM Jr, John K, John CM (2002) Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease: potential role in disease pathogenesis. J Neurochem 82(4):809\u2013818","journal-title":"J Neurochem"},{"issue":"3","key":"9293_CR30","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S1568-1637(02)00012-0","volume":"1","author":"JJ Harding","year":"2002","unstructured":"Harding JJ (2002) Viewing molecular mechanisms of ageing through a lens. Ageing Res Rev 1(3):465\u2013479","journal-title":"Ageing Res Rev"},{"issue":"3","key":"9293_CR31","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1214\/ss\/1177013604","volume":"1","author":"T Hastie","year":"1986","unstructured":"Hastie T, Tibshirani R (1986) Generalised additive models. Stat Sci 1(3):297\u2013310","journal-title":"Stat Sci"},{"key":"9293_CR32","first-page":"956","volume":"10","author":"KR Heys","year":"2004","unstructured":"Heys KR, Cram SL, Truscott RJW (2004) Massive increase in the stiffness of the human lens nucleus with age: the basis for presbyopia? Mol Vis 10:956\u2013963","journal-title":"Mol Vis"},{"issue":"5","key":"9293_CR33","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1167\/iovs.07-1151","volume":"49","author":"KR Heys","year":"2008","unstructured":"Heys KR, Friedrich MG, Truscott RJW (2008) Free and bound water in normal and cataractous human lenses. Investig Ophthalmol Vis Sci 49(5):1991\u20131997","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"9293_CR34","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/BF02537295","volume":"22","author":"RJY Ho","year":"1987","unstructured":"Ho RJY, Schmetz M, Deamer DW (1987) Nonenzymatic hydrolysis of phosphatidylcholine prepared as liposomes and mixed micelles. Lipids 22:156\u2013158","journal-title":"Lipids"},{"issue":"11","key":"9293_CR35","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1016\/j.jasms.2007.08.019","volume":"18","author":"FF Hsu","year":"2007","unstructured":"Hsu FF, Turk J (2007) Differentiation of 1-O-alk-1\u2032-enyl-2-acyl and 1-O-alkyl-2-acyl glycerophospholipids by multiple-stage linear ion-trap mass spectrometry with electrospray ionization. J Am Soc Mass Spectrom 18(11):2065\u20132073","journal-title":"J Am Soc Mass Spectrom"},{"issue":"5","key":"9293_CR36","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1167\/iovs.04-1155","volume":"46","author":"L Huang","year":"2005","unstructured":"Huang L, Grami V, Marrero Y, Tang D, Yappert MC, Rasi V, Borchman D (2005) Human lens phospholipid changes with age and cataract. Investig Ophthalmol Vis Sci 46(5):1682\u20131689","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"2","key":"9293_CR37","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.bbamem.2006.02.016","volume":"1758","author":"LM Ickenstein","year":"2006","unstructured":"Ickenstein LM, Sandstr\u00f6m MC, Mayer LD, Edwards K (2006) Effects of phospholipid hydrolysis on the aggregate structure in DPPC\/DSPE-PEG2000 liposome preparations after gel to liquid crystalline phase transition. Biochim Biophys Acta 1758(2):171\u2013180","journal-title":"Biochim Biophys Acta"},{"issue":"9","key":"9293_CR38","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1248\/bpb.19.1223","volume":"19","author":"A Kamei","year":"1996","unstructured":"Kamei A (1996) Properties of partially purified esterase in human crystalline lens and variation in its enzyme activity during aging and with advance of senile cataract. Biol Pharm Bull 19(9):1223\u20131226","journal-title":"Biol Pharm Bull"},{"key":"9293_CR39","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1016\/S0021-9258(18)91247-0","volume":"239","author":"J Kanfer","year":"1964","unstructured":"Kanfer J, Kennedy EP (1964) Metabolism and function of bacterial lipids: II. Biosynthesis of phospholipids in Escherischia coli. J Biol Chem 239:1720\u20131726","journal-title":"J Biol Chem"},{"issue":"1","key":"9293_CR40","doi-asserted-by":"crossref","first-page":"e1529","DOI":"10.1371\/journal.pone.0001529","volume":"3","author":"N Lynnerup","year":"2008","unstructured":"Lynnerup N, Kjeldsen H, Heegaard S, Jacobsen C, Heinemeier J (2008) Radiocarbon dating of the human eye lens crystallines reveal proteins without carbon turnover throughout life. PLoS ONE 3(1):e1529","journal-title":"PLoS ONE"},{"issue":"3\u20134","key":"9293_CR41","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0891-5849(98)00208-1","volume":"26","author":"P Mecocci","year":"1999","unstructured":"Mecocci P, Fan\u00f3 G, Fulle S, MacGarvey U, Shinobu L, Polidori MC, Cherubini A, Vecchiet J, Senin U, Beal MF (1999) Age-dependent increases in oxidative damage to DNA, lipids, and proteins in human skeletal muscle. Free Radic Biol Med 26(3\u20134):303\u2013308","journal-title":"Free Radic Biol Med"},{"issue":"3","key":"9293_CR42","first-page":"549","volume":"32","author":"TE Merchant","year":"1991","unstructured":"Merchant TE, Lass JH, Meneses P, Greiner JV, Glonek T (1991) Human crystalline lens phospholipid analysis with age. Invest Ophthalmol Vis Sci 32(3):549\u2013555","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"9293_CR43","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1007\/s00268-005-0742-1","volume":"31","author":"E Messaris","year":"2007","unstructured":"Messaris E, Kekis P, Memos N, Chatzigianni E, Menenakos E, Leandros E, Konstadoulakis MM (2007) Sepsis: prognostic role of apoptosis regulators in gastrointestinal cells. World J Surg 31(4):787\u2013794","journal-title":"World J Surg"},{"key":"9293_CR44","doi-asserted-by":"crossref","unstructured":"Meulle A, Salles B, Daviaud D, Valet P, Muller C (2008) Positive regulation of DNA double strand break repair activity during differentiation of long life span cells: the example of adipogenesis. Plos One 3(10)","DOI":"10.1371\/journal.pone.0003345"},{"issue":"6","key":"9293_CR45","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1006\/exer.1999.0747","volume":"69","author":"BA Moffat","year":"1999","unstructured":"Moffat BA, Landman KA, Truscott RJW, Sweeney MHJ, Pope JM (1999) Age-related changes in the kinetics of water transport in normal human lenses. Exp Eye Res 69(6):663\u2013669","journal-title":"Exp Eye Res"},{"issue":"2","key":"9293_CR46","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1083\/jcb.44.2.459","volume":"44","author":"FP Moss","year":"1970","unstructured":"Moss FP, Leblond CP (1970) Nature of dividing nuclei in skeletal muscle of growing rats. J Cell Biol 44(2):459\u2013461","journal-title":"J Cell Biol"},{"issue":"6","key":"9293_CR47","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.exer.2008.08.009","volume":"87","author":"JR Nealon","year":"2008","unstructured":"Nealon JR, Blanksby SJ, Abbott SK, Hulbert AJ, Mitchell TW, Truscott RJW (2008a) Phospholipid composition of the rat lens is independent of diet. Exp Eye Res 87(6):502\u2013514","journal-title":"Exp Eye Res"},{"issue":"Pt 19","key":"9293_CR48","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1242\/jeb.019968","volume":"211","author":"JR Nealon","year":"2008","unstructured":"Nealon JR, Blanksby SJ, Mitchell TW, Else PL (2008b) Systematic differences in membrane acyl composition associated with varying body mass in mammals occur in all phospholipid classes: an analysis of kidney and brain. J Exp Biol 211(Pt 19):3195\u20133204","journal-title":"J Exp Biol"},{"key":"9293_CR49","doi-asserted-by":"crossref","unstructured":"Nealon JR, Blanksby SJ, Donaldson PJ, Truscott RJW, Mitchell TW (2011) Fatty acid uptake and incorporation into phospholipids in the rat lens. Investig Ophthalmol Vis Sci 52(2):804\u2013809","DOI":"10.1167\/iovs.10-5830"},{"issue":"33","key":"9293_CR50","doi-asserted-by":"crossref","first-page":"12219","DOI":"10.1073\/pnas.0605605103","volume":"103","author":"RS Nowakowski","year":"2006","unstructured":"Nowakowski RS (2006) Stable neuron numbers from cradle to grave. Proc Natl Acad Sci U S A 103(33):12219\u201312220","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"9293_CR51","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0009-3084(03)00003-3","volume":"123","author":"EM Oborina","year":"2003","unstructured":"Oborina EM, Yappert MC (2003) Effect of sphingomyelin versus dipalmitoylphosphatidylcholine on the extent of lipid oxidation. Chem Phys Lipids 123(2):223\u2013232","journal-title":"Chem Phys Lipids"},{"key":"9293_CR52","doi-asserted-by":"crossref","first-page":"13242","DOI":"10.1016\/S0021-9258(19)38643-0","volume":"268","author":"M Ogiso","year":"1993","unstructured":"Ogiso M, Irie A, Kubo H, Komoto M, Matsuno T, Koide Y, Hoshi M (1993) Characterisation of neutral glycosphingolipids in human cataractous lens. J Biol Chem 268:13242\u201313247","journal-title":"J Biol Chem"},{"issue":"6","key":"9293_CR53","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1006\/exer.1994.1151","volume":"59","author":"M Ogiso","year":"1994","unstructured":"Ogiso M, Okinaga T, Komoto M, Nishiyama I, Hoshi M (1994) Comparative-study of glycosphingolipid composition in mammalian lenses. Exp Eye Res 59(6):653\u2013663","journal-title":"Exp Eye Res"},{"issue":"1","key":"9293_CR54","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1093\/glycob\/8.1.95","volume":"8","author":"M Ogiso","year":"1998","unstructured":"Ogiso M, Shogomori H, Hoshi M (1998) Localization of LewisX, sialyl-LewisX and alpha-galactosyl epitopes on glycosphingolipids in lens tissues. Glycobiology 8(1):95\u2013105","journal-title":"Glycobiology"},{"issue":"4","key":"9293_CR55","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1167\/iovs.02-0786","volume":"44","author":"M Rujoi","year":"2003","unstructured":"Rujoi M, Jin J, Borchman D, Tang D, Yappert MC (2003) Isolation and lipid characterisation of cholesterol-enriched fractions in cortical and nuclear human lens fibers. Investig Ophthalmol Vis Sci 44(4):1634\u20131642","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"9293_CR56","doi-asserted-by":"crossref","first-page":"17199","DOI":"10.1074\/jbc.273.27.17199","volume":"273","author":"K Saito","year":"1998","unstructured":"Saito K, Nishijima M, Kuge O (1998) Genetic evidence that phosphatidylserine synthase II catalyzes the conversion of phosphatidylethanolamine to phosphatidylserine in Chinese hamster ovary cells. J Biol Chem 273:17199\u201317205","journal-title":"J Biol Chem"},{"key":"9293_CR57","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0021-9258(17)38234-0","volume":"253","author":"M Satre","year":"1978","unstructured":"Satre M, Kennedy EP (1978) Identification of bound pyruvate essential for the activity of phosphatidylserine decarboxylase of Escherichia coli. J Biol Chem 253:479\u2013483","journal-title":"J Biol Chem"},{"issue":"2","key":"9293_CR58","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/BF02160345","volume":"225","author":"J Scharf","year":"1987","unstructured":"Scharf J, Dovrat A, Gershon D (1987) Defective superoxide-dimutase molecules accumulate with age in human lenses. Graefe's Arch Clin Exp Ophthalmol 225(2):133\u2013136","journal-title":"Graefe's Arch Clin Exp Ophthalmol"},{"issue":"2","key":"9293_CR59","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/j.1471-4159.1988.tb02960.x","volume":"50","author":"R Shapira","year":"1988","unstructured":"Shapira R, Wilkinson KD, Shapira G (1988) Racemization of individual aspartate residues in human myelin basic protein. J Neurochem 50(2):649\u2013654","journal-title":"J Neurochem"},{"issue":"4","key":"9293_CR60","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1046\/j.1471-4159.1996.67041702.x","volume":"67","author":"HU Shetty","year":"1996","unstructured":"Shetty HU, Quentin RS, Kazushige W, Stanley IR (1996) Identification of two molecular species of rat brain phosphatidylcholine that rapidly incorporate and turn over arachidonic acid in vivo. J Neurochem 67(4):1702\u20131710","journal-title":"J Neurochem"},{"issue":"2","key":"9293_CR61","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1471-4159.1990.tb01889.x","volume":"54","author":"M S\u00f6derberg","year":"1990","unstructured":"S\u00f6derberg M, Edlund C, Kristensson K, Dallner G (1990) Lipid compositions of different regions of the human brain during aging. J Neurochem 54(2):415\u2013423","journal-title":"J Neurochem"},{"issue":"7196","key":"9293_CR62","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/nature06902","volume":"453","author":"KL Spalding","year":"2008","unstructured":"Spalding KL, Arner E, Westermark PO, Bernard S, Buchholz BA, Bergmann O, Blomqvist L, Hoffstedt J, Naslund E, Britton T, Concha H, Hassan M, Ryden M, Frisen J, Arner P (2008) Dynamics of fat cell turnover in humans. Nature 453(7196):783\u2013787","journal-title":"Nature"},{"issue":"3","key":"9293_CR63","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.freeradbiomed.2006.03.013","volume":"41","author":"G Spiteller","year":"2006","unstructured":"Spiteller G (2006) Peroxyl radicals: inductors of neurodegenerative and other inflammatory diseases. Their origin and how they transform cholesterol, phospholipids, plasmalogens, polyunsaturated fatty acids, sugars, and proteins into deleterious products. Free Radic Biol Med 41(3):362\u2013387","journal-title":"Free Radic Biol Med"},{"issue":"6","key":"9293_CR64","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1111\/j.1471-4159.1978.tb10470.x","volume":"30","author":"L Svennerholm","year":"1978","unstructured":"Svennerholm L, Vanier MT, Jungbjer B (1978) Changes in fatty acid composition of human brain myelin lipids during maturation. J Neurochem 30(6):1383\u20131390","journal-title":"J Neurochem"},{"issue":"6","key":"9293_CR65","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1111\/j.1471-4159.1991.tb03466.x","volume":"56","author":"L Svennerholm","year":"1991","unstructured":"Svennerholm L, Bostr\u00f6m K, Helander CG, Jungbjer B (1991) Membrane lipids in the aging human brain. J Neurochem 56(6):2051\u20132059","journal-title":"J Neurochem"},{"issue":"5","key":"9293_CR66","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1046\/j.1471-4159.1994.63051802.x","volume":"63","author":"L Svennerholm","year":"1994","unstructured":"Svennerholm L, Bostr\u00f6m K, Jungbjer B, Olsson L (1994) Membrane lipids of adult human brain:lipid composition of frontal and temporal lobe in subjects of age 20 to 100\u00a0years. J Neurochem 63(5):1802\u20131811","journal-title":"J Neurochem"},{"issue":"5","key":"9293_CR67","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1006\/exer.1998.0549","volume":"67","author":"MHJ Sweeney","year":"1998","unstructured":"Sweeney MHJ, Truscott RJW (1998) An impediment to glutathione diffusion in older normal human lenses: a possible precondition for nuclear cataract. Exp Eye Res 67(5):587\u2013595","journal-title":"Exp Eye Res"},{"key":"9293_CR68","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0005-2760(75)90029-6","volume":"409","author":"RVP Tao","year":"1975","unstructured":"Tao RVP, Cotlier E (1975) Ceramides of human normal and cataractous lens. Biochim Biophys Acta 409:329\u2013341","journal-title":"Biochim Biophys Acta"},{"issue":"5","key":"9293_CR69","doi-asserted-by":"crossref","first-page":"R1273","DOI":"10.1152\/ajpregu.1994.267.5.R1273","volume":"267","author":"F Thies","year":"1994","unstructured":"Thies F, Pillon C, Moliere P, Lagarde M, Lecerf J (1994) Preferential incorporation of sn-2 lysoPC DHA over unesterified DHA in the young rat brain. Am J Physiol Regul Integr Comp Physiol 267(5):R1273\u2013R1279","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"5","key":"9293_CR70","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.exer.2004.12.007","volume":"80","author":"RJW Truscott","year":"2005","unstructured":"Truscott RJW (2005) Age-related nuclear cataract\u2014oxidation is the key. Exp Eye Res 80(5):709\u2013725","journal-title":"Exp Eye Res"},{"issue":"2","key":"9293_CR71","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.exer.2008.07.003","volume":"88","author":"RJ Truscott","year":"2009","unstructured":"Truscott RJ (2009) Presbyopia. Emerging from a blur towards an understanding of the molecular basis for this most common eye condition. Exp Eye Res 88(2):241\u2013247","journal-title":"Exp Eye Res"},{"issue":"6","key":"9293_CR72","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.preteyeres.2010.05.002","volume":"29","author":"RJW Truscott","year":"2010","unstructured":"Truscott RJW, Zhu X (2010) Presbyopia and cataract: a question of heat and time. Prog Retinal Eye Res 29(6):487\u2013499","journal-title":"Prog Retinal Eye Res"},{"key":"9293_CR73","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1198\/016214504000000980","volume":"99","author":"SN Wood","year":"2004","unstructured":"Wood SN (2004) Stable and efficient multiple smoothing parameter estimation for generalized additive models. J Am Stat Assoc 99:673\u2013686","journal-title":"J Am Stat Assoc"},{"issue":"1","key":"9293_CR74","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.chemphyslip.2003.12.003","volume":"129","author":"MC Yappert","year":"2004","unstructured":"Yappert MC, Borchman D (2004) Sphingolipids in human lens membranes: an update on their composition and possible biological implications. Chem Phys Lipids 129(1):1\u201320","journal-title":"Chem Phys Lipids"},{"issue":"13","key":"9293_CR75","first-page":"3555","volume":"33","author":"MC Yappert","year":"1992","unstructured":"Yappert MC, Lal S, Borchman D (1992) Age dependence and distribution of green and blue fluorophores in human lens homogenates. Investig Ophthalmol Vis Sci 33(13):3555\u20133560","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"6","key":"9293_CR76","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S0014-4835(03)00051-4","volume":"76","author":"MC Yappert","year":"2003","unstructured":"Yappert MC, Rujoi M, Borchman D, Vorobyov I, Estrada R (2003) Glycero- versus sphingo-phospholipids: correlations with human and non-human mammalian lens growth. Exp Eye Res 76(6):725\u2013734","journal-title":"Exp Eye Res"},{"issue":"10","key":"9293_CR77","doi-asserted-by":"crossref","first-page":"5162","DOI":"10.1167\/iovs.09-4947","volume":"51","author":"X Zhu","year":"2010","unstructured":"Zhu X, Gaus K, Lu Y, Magenau A, Truscott RJW, Mitchell TW (2010a) Alpha- and beta-crystallins modulate the head group order of human lens membranes during aging. Investig Ophthalmol Vis Sci 51(10):5162\u20135167","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"5","key":"9293_CR78","first-page":"1","volume":"13","author":"X Zhu","year":"2010","unstructured":"Zhu X, Korlimbinis A, Truscott RJ (2010b) Age-dependent denaturation of enzymes in the human body. Rejuven Res 13(5):1\u20138","journal-title":"Rejuven Res"},{"issue":"7","key":"9293_CR79","doi-asserted-by":"crossref","first-page":"887","DOI":"10.3109\/02713688409167206","volume":"3","author":"S Zigman","year":"1984","unstructured":"Zigman S, Paxhia T, Marinetti G, Girsch S (1984) Lipids of human lens fiber cell membranes. Curr Eye Res 3(7):887\u2013896","journal-title":"Curr Eye Res"}],"container-title":["AGE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11357-011-9293-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11357-011-9293-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11357-011-9293-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T15:08:07Z","timestamp":1638544087000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11357-011-9293-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,6]]},"references-count":79,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["9293"],"URL":"https:\/\/doi.org\/10.1007\/s11357-011-9293-6","relation":{},"ISSN":["0161-9152","1574-4647"],"issn-type":[{"value":"0161-9152","type":"print"},{"value":"1574-4647","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,6]]}}}