{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T22:17:43Z","timestamp":1773094663347,"version":"3.50.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2015,4,25]],"date-time":"2015-04-25T00:00:00Z","timestamp":1429920000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["AGE"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1007\/s11357-015-9776-y","type":"journal-article","created":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T14:16:44Z","timestamp":1429885004000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["A preliminary candidate approach identifies the combination of chemerin, fetuin-A, and fibroblast growth factors 19 and 21 as a potential biomarker panel of successful aging"],"prefix":"10.1007","volume":"37","author":[{"given":"Fabian","family":"Sanchis-Gomar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helios","family":"Pareja-Galeano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Santos-Lozano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuria","family":"Garatachea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Fiuza-Luces","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Letizia","family":"Venturini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Ricevuti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Lucia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enzo","family":"Emanuele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,4,25]]},"reference":[{"key":"9776_CR1","doi-asserted-by":"crossref","first-page":"e49977","DOI":"10.1371\/journal.pone.0049977","volume":"7","author":"AC Adams","year":"2012","unstructured":"Adams AC, Cheng CC, Coskun T, Kharitonenkov A (2012) FGF21 requires betaklotho to act in vivo. PLoS ONE 7:e49977","journal-title":"PLoS ONE"},{"key":"9776_CR2","doi-asserted-by":"crossref","unstructured":"Ailshire JA, Beltran-Sanchez H, Crimmins EM (2014) Becoming Centenarians: Disease and Functioning Trajectories of Older U.S. Adults as They Survive to 100. J Gerontol A Biol Sci Med Sci","DOI":"10.1093\/gerona\/glu124"},{"key":"9776_CR3","first-page":"390","volume":"41","author":"B Barutcuoglu","year":"2011","unstructured":"Barutcuoglu B, Basol G, Cakir Y, Cetinkalp S, Parildar Z, Kabaroglu C, Ozmen D, Mutaf I, Bayindir O (2011) Fibroblast growth factor-19 levels in type 2 diabetic patients with metabolic syndrome. Ann Clin Lab Sci 41:390\u2013396","journal-title":"Ann Clin Lab Sci"},{"key":"9776_CR4","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.archger.2011.05.004","volume":"54","author":"G Basile","year":"2012","unstructured":"Basile G, Paffumi I, D\u2019Angelo AG, Figliomeni P, Cucinotta MD, Pace E, Ferraro M, Saitta S, Lasco A, Gangemi S (2012) Healthy centenarians show high levels of circulating interleukin-22 (IL-22). Arch Gerontol Geriatr 54:459\u2013461","journal-title":"Arch Gerontol Geriatr"},{"key":"9776_CR5","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.exger.2013.01.015","volume":"48","author":"W Bik","year":"2013","unstructured":"Bik W, Baranowska-Bik A, Wolinska-Witort E, Kalisz M, Broczek K, Mossakowska M, Baranowska B (2013) Assessment of adiponectin and its isoforms in Polish centenarians. Exp Gerontol 48:401\u2013407","journal-title":"Exp Gerontol"},{"key":"9776_CR6","doi-asserted-by":"crossref","first-page":"13274","DOI":"10.1073\/pnas.0804931105","volume":"105","author":"K Christensen","year":"2008","unstructured":"Christensen K, McGue M, Petersen I, Jeune B, Vaupel JW (2008) Exceptional longevity does not result in excessive levels of disability. Proc Natl Acad Sci U S A 105:13274\u201313279","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9776_CR7","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.neurobiolaging.2009.07.003","volume":"32","author":"E Emanuele","year":"2011","unstructured":"Emanuele E, Lista S, Ghidoni R, Binetti G, Cereda C, Benussi L, Maletta R, Bruni AC, Politi P (2011) Chromosome 9p21.3 genotype is associated with vascular dementia and Alzheimer\u2019s disease. Neurobiol Aging 32:1231\u20131235","journal-title":"Neurobiol Aging"},{"key":"9776_CR8","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.amjmed.2014.04.025","volume":"127","author":"E Emanuele","year":"2014","unstructured":"Emanuele E, Minoretti P, Pareja-Galeano H, Sanchis-Gomar F, Garatachea N, Lucia A (2014a) Serum irisin levels, precocious myocardial infarction, and healthy exceptional longevity. Am J Med 127:888\u2013890","journal-title":"Am J Med"},{"key":"9776_CR9","doi-asserted-by":"crossref","unstructured":"Emanuele E, Minoretti P, Sanchis-Gomar F, Pareja-Galeano H, Yilmaz Y, Garatachea N , Lucia A (2014b) Can Enhanced Autophagy be Associated with Human Longevity? Serum Levels of the Autophagy Biomarker Beclin-1 are Increased in Healthy Centenarians. Rejuvenation Res","DOI":"10.1089\/rej.2014.1607"},{"key":"9776_CR10","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.2337\/dc12-1766","volume":"36","author":"Q Fang","year":"2013","unstructured":"Fang Q, Li H, Song Q, Yang W, Hou X, Ma X, Lu J, Xu A, Jia W (2013) Serum fibroblast growth factor 19 levels are decreased in Chinese subjects with impaired fasting glucose and inversely associated with fasting plasma glucose levels. Diabetes Care 36:2810\u20132814","journal-title":"Diabetes Care"},{"key":"9776_CR11","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.peptides.2014.09.019","volume":"62C","author":"SS Fatima","year":"2014","unstructured":"Fatima SS, Rehman R, Baig M, Khan TA (2014) New roles of the multidimensional adipokine: Chemerin. Peptides 62C:15\u201320","journal-title":"Peptides"},{"key":"9776_CR12","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3758\/BF03193146","volume":"39","author":"F Faul","year":"2007","unstructured":"Faul F, Erdfelder E, Lang AG, Buchner A (2007) G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 39:175\u2013191","journal-title":"Behav Res Methods"},{"key":"9776_CR13","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S0531-5565(03)00061-5","volume":"38","author":"S Gangemi","year":"2003","unstructured":"Gangemi S, Basile G, Merendino RA, Minciullo PL, Novick D, Rubinstein M, Dinarello CA, Lo Balbo C, Franceschi C, Basili S, DU E, Davi G, Nicita-Mauro V, Romano M (2003) Increased circulating Interleukin-18 levels in centenarians with no signs of vascular disease: another paradox of longevity? Exp Gerontol 38:669\u2013672","journal-title":"Exp Gerontol"},{"key":"9776_CR14","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1089\/rej.2009.0968","volume":"13","author":"NS Gavrilova","year":"2010","unstructured":"Gavrilova NS, Gavrilov LA (2010) Search for mechanisms of exceptional human longevity. Rejuvenation Res 13:262\u2013264","journal-title":"Rejuvenation Res"},{"key":"9776_CR15","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0047-6374(00)00195-0","volume":"121","author":"R Gerli","year":"2000","unstructured":"Gerli R, Monti D, Bistoni O, Mazzone AM, Peri G, Cossarizza A, Di Gioacchino M, Cesarotti ME, Doni A, Mantovani A, Franceschi C, Paganelli R (2000) Chemokines, sTNF-Rs and sCD30 serum levels in healthy aged people and centenarians. Mech Ageing Dev 121:37\u201346","journal-title":"Mech Ageing Dev"},{"key":"9776_CR16","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1111\/j.1532-5415.2006.00776.x","volume":"54","author":"D Geroldi","year":"2006","unstructured":"Geroldi D, Falcone C, Minoretti P, Emanuele E, Arra M, D\u2019Angelo A (2006) High levels of soluble receptor for advanced glycation end products may be a marker of extreme longevity in humans. J Am Geriatr Soc 54:1149\u20131150","journal-title":"J Am Geriatr Soc"},{"key":"9776_CR17","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.maturitas.2012.09.012","volume":"73","author":"V Gremeaux","year":"2012","unstructured":"Gremeaux V, Gayda M, Lepers R, Sosner P, Juneau M, Nigam A (2012) Exercise and longevity. Maturitas 73:312\u2013317","journal-title":"Maturitas"},{"key":"9776_CR18","doi-asserted-by":"crossref","first-page":"e72345","DOI":"10.1371\/journal.pone.0072345","volume":"8","author":"Y Hao","year":"2013","unstructured":"Hao Y, Zhou J, Zhou M, Ma X, Lu Z, Gao M, Pan X, Tang J, Bao Y, Jia W (2013) Serum levels of fibroblast growth factor 19 are inversely associated with coronary artery disease in chinese individuals. PLoS ONE 8:e72345","journal-title":"PLoS ONE"},{"key":"9776_CR19","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1038\/nm.2869","volume":"18","author":"J Heinrichsdorff","year":"2012","unstructured":"Heinrichsdorff J, Olefsky JM (2012) Fetuin-A: the missing link in lipid-induced inflammation. Nat Med 18:1182\u20131183","journal-title":"Nat Med"},{"key":"9776_CR20","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1126\/science.1198363","volume":"331","author":"S Kir","year":"2011","unstructured":"Kir S, Beddow SA, Samuel VT, Miller P, Previs SF, Suino-Powell K, Xu HE, Shulman GI, Kliewer SA, Mangelsdorf DJ (2011) FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis. Science 331:1621\u20131624","journal-title":"Science"},{"key":"9776_CR21","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s00424-009-0722-7","volume":"459","author":"M Kuro-o","year":"2010","unstructured":"Kuro-o M (2010) Klotho. Pflugers Arch 459:333\u2013343","journal-title":"Pflugers Arch"},{"key":"9776_CR22","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1177\/1754045314521551","volume":"20","author":"GW Leeson","year":"2014","unstructured":"Leeson GW (2014) Future prospects for longevity. Post Reprod Health 20:11\u201315","journal-title":"Post Reprod Health"},{"key":"9776_CR23","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1007\/s12603-014-0459-7","volume":"18","author":"SK Malin","year":"2014","unstructured":"Malin SK, Navaneethan SD, Mulya A, Huang H, Kirwan JP (2014) Exercise-induced lowering of chemerin is associated with reduced cardiometabolic risk and glucose-stimulated insulin secretion in older adults. J Nutr Health Aging 18:608\u2013615","journal-title":"J Nutr Health Aging"},{"key":"9776_CR24","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.bbrc.2006.09.071","volume":"350","author":"ST Mathews","year":"2006","unstructured":"Mathews ST, Rakhade S, Zhou X, Parker GC, Coscina DV, Grunberger G (2006) Fetuin-null mice are protected against obesity and insulin resistance associated with aging. Biochem Biophys Res Commun 350:437\u2013443","journal-title":"Biochem Biophys Res Commun"},{"key":"9776_CR25","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/B978-0-12-394317-0.00010-8","volume":"56","author":"K Mori","year":"2012","unstructured":"Mori K, Emoto M, Inaba M (2012) Fetuin-A and the cardiovascular system. Adv Clin Chem 56:175\u2013195","journal-title":"Adv Clin Chem"},{"key":"9776_CR26","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.ygyno.2010.02.005","volume":"117","author":"B Nolen","year":"2010","unstructured":"Nolen B, Velikokhatnaya L, Marrangoni A, De Geest K, Lomakin A, Bast RC Jr, Lokshin A (2010) Serum biomarker panels for the discrimination of benign from malignant cases in patients with an adnexal mass. Gynecol Oncol 117:440\u2013445","journal-title":"Gynecol Oncol"},{"key":"9776_CR27","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1007\/s12020-012-9754-4","volume":"42","author":"S Rasul","year":"2012","unstructured":"Rasul S, Wagner L, Kautzky-Willer A (2012) Fetuin-A and angiopoietins in obesity and type 2 diabetes mellitus. Endocrine 42:496\u2013505","journal-title":"Endocrine"},{"key":"9776_CR28","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1159\/000358907","volume":"39","author":"L Robert","year":"2014","unstructured":"Robert L, Fulop T (2014) Longevity and its regulation: centenarians and beyond. Interdiscip Top Gerontol 39:198\u2013211","journal-title":"Interdiscip Top Gerontol"},{"key":"9776_CR29","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1007\/s12020-013-0003-2","volume":"45","author":"T Stefanov","year":"2014","unstructured":"Stefanov T, Bluher M, Vekova A, Bonova I, Tzvetkov S, Kurktschiev D, Temelkova-Kurktschiev T (2014) Circulating chemerin decreases in response to a combined strength and endurance training. Endocrine 45:382\u2013391","journal-title":"Endocrine"},{"key":"9776_CR30","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1001\/archinternmed.2007.75","volume":"168","author":"DF Terry","year":"2008","unstructured":"Terry DF, Sebastiani P, Andersen SL, Perls TT (2008) Disentangling the roles of disability and morbidity in survival to exceptional old age. Arch Intern Med 168:277\u2013283","journal-title":"Arch Intern Med"},{"key":"9776_CR31","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1073\/pnas.0913986107","volume":"107","author":"K Tomiyama","year":"2010","unstructured":"Tomiyama K, Maeda R, Urakawa I, Yamazaki Y, Tanaka T, Ito S, Nabeshima Y, Tomita T, Odori S, Hosoda K, Nakao K, Imura A (2010) Relevant use of Klotho in FGF19 subfamily signaling system in vivo. Proc Natl Acad Sci U S A 107:1666\u20131671","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9776_CR32","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1038\/oby.2011.364","volume":"20","author":"SG Trost","year":"2012","unstructured":"Trost SG, Fees BS, Haar SJ, Murray AD, Crowe LK (2012) Identification and validity of accelerometer cut-points for toddlers. Obesity (Silver Spring) 20:2317\u20132319","journal-title":"Obesity (Silver Spring)"},{"key":"9776_CR33","doi-asserted-by":"crossref","first-page":"e81190","DOI":"10.1371\/journal.pone.0081190","volume":"8","author":"D Wang","year":"2013","unstructured":"Wang D, Zhu W, Li J, An C, Wang Z (2013) Serum concentrations of fibroblast growth factors 19 and 21 in women with gestational diabetes mellitus: association with insulin resistance, adiponectin, and polycystic ovary syndrome history. PLoS ONE 8:e81190","journal-title":"PLoS ONE"},{"key":"9776_CR34","first-page":"1089","volume":"25","author":"M Wojcik","year":"2012","unstructured":"Wojcik M, Janus D, Dolezal-Oltarzewska K, Kalicka-Kasperczyk A, Poplawska K, Drozdz D, Sztefko K, Starzyk JB (2012) A decrease in fasting FGF19 levels is associated with the development of non-alcoholic fatty liver disease in obese adolescents. J Pediatr Endocrinol Metab 25:1089\u20131093","journal-title":"J Pediatr Endocrinol Metab"},{"key":"9776_CR35","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/cen.12095","volume":"78","author":"YC Woo","year":"2013","unstructured":"Woo YC, Xu A, Wang Y, Lam KS (2013) Fibroblast growth factor 21 as an emerging metabolic regulator: clinical perspectives. Clin Endocrinol (Oxf) 78:489\u2013496","journal-title":"Clin Endocrinol (Oxf)"},{"key":"9776_CR36","doi-asserted-by":"crossref","first-page":"e17868","DOI":"10.1371\/journal.pone.0017868","volume":"6","author":"AL Wu","year":"2011","unstructured":"Wu AL, Coulter S, Liddle C, Wong A, Eastham-Anderson J, French DM, Peterson AS, Sonoda J (2011) FGF19 regulates cell proliferation, glucose and bile acid metabolism via FGFR4-dependent and independent pathways. PLoS ONE 6:e17868","journal-title":"PLoS ONE"},{"key":"9776_CR37","doi-asserted-by":"crossref","first-page":"e00065","DOI":"10.7554\/eLife.00065","volume":"1","author":"Y Zhang","year":"2012","unstructured":"Zhang Y, Xie Y, Berglund ED, Coate KC, He TT, Katafuchi T, Xiao G, Potthoff MJ, Wei W, Wan Y, Yu RT, Evans RM, Kliewer SA, Mangelsdorf DJ (2012) The starvation hormone, fibroblast growth factor-21, extends lifespan in mice. Elife 1:e00065","journal-title":"Elife"}],"container-title":["AGE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11357-015-9776-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11357-015-9776-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11357-015-9776-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,24]],"date-time":"2019-08-24T02:09:26Z","timestamp":1566612566000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11357-015-9776-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,25]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["9776"],"URL":"https:\/\/doi.org\/10.1007\/s11357-015-9776-y","relation":{},"ISSN":["0161-9152","1574-4647"],"issn-type":[{"value":"0161-9152","type":"print"},{"value":"1574-4647","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,25]]},"article-number":"42"}}