{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T03:23:32Z","timestamp":1788492212979,"version":"build-2803163510"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000965","name":"American Federation for Aging Research","doi-asserted-by":"publisher","award":["2015-030"],"award-info":[{"award-number":["2015-030"]}],"id":[{"id":"10.13039\/100000965","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000965","name":"American Federation for Aging Research","doi-asserted-by":"publisher","award":["Glenn\/AFAR Scholarship"],"award-info":[{"award-number":["Glenn\/AFAR Scholarship"]}],"id":[{"id":"10.13039\/100000965","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19-AG023122"],"award-info":[{"award-number":["U19-AG023122"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["1435655"],"award-info":[{"award-number":["1435655"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["GeroScience"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1007\/s11357-019-00062-6","type":"journal-article","created":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T11:20:14Z","timestamp":1554117614000},"page":"229-242","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Cellular energetics and mitochondrial uncoupling in canine aging"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5433-3041","authenticated-orcid":false,"given":"Justin W.","family":"Nicholatos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy M.","family":"Robinette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurabh V.P.","family":"Tata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer D.","family":"Yordy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam B.","family":"Francisco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Platov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany K.","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga R.","family":"Ilkayeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank K.","family":"Huynh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxim","family":"Dokukin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmytro","family":"Volkov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Weinstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam R.","family":"Boyko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Sokolov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D.","family":"Hirschey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergiy","family":"Libert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,4,1]]},"reference":[{"key":"62_CR1","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1038\/nm995","volume":"10","author":"J An","year":"2004","unstructured":"An J, Muoio DM, Shiota M, Fujimoto Y, Cline GW, Shulman GI, Koves TR, Stevens R, Millington D, Newgard CB (2004) Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance. Nat Med 10:268\u2013274","journal-title":"Nat Med"},{"key":"62_CR2","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/bjc.2011.245","volume":"105","author":"G Baffy","year":"2011","unstructured":"Baffy G, Derdak Z, Robson SC (2011) Mitochondrial recoupling: a novel therapeutic strategy for cancer? Br J Cancer 105:469\u2013474","journal-title":"Br J Cancer"},{"key":"62_CR3","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms16082","volume":"8","author":"LR Botigue","year":"2017","unstructured":"Botigue LR, Song S, Scheu A, Gopalan S, Pendleton AL, Oetjens M, Taravella AM, Seregely T, Zeeb-Lanz A, Arbogast RM, Bobo D, Daly K, Unterlander M, Burger J, Kidd JM, Veeramah KR (2017) Ancient European dog genomes reveal continuity since the Early Neolithic. Nat Commun 8:16082","journal-title":"Nat Commun"},{"key":"62_CR4","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/S0531-5565(00)00135-2","volume":"35","author":"MD Brand","year":"2000","unstructured":"Brand MD (2000) Uncoupling to survive? The role of mitochondrial inefficiency in ageing. Exp Gerontol 35:811\u2013820","journal-title":"Exp Gerontol"},{"key":"62_CR5","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.freeradbiomed.2004.05.034","volume":"37","author":"MD Brand","year":"2004","unstructured":"Brand MD, Affourtit C, Esteves TC, Green K, Lambert AJ, Miwa S, Pakay JL, Parker N (2004) Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins. Free Radic Biol Med 37:755\u2013767","journal-title":"Free Radic Biol Med"},{"key":"62_CR6","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1126\/science.1177808","volume":"326","author":"E Cadieu","year":"2009","unstructured":"Cadieu E, Neff MW, Quignon P, Walsh K, Chase K, Parker HG, Vonholdt BM, Rhue A, Boyko A, Byers A, Wong A, Mosher DS, Elkahloun AG, Spady TC, Andre C, Lark KG, Cargill M, Bustamante CD, Wayne RK, Ostrander EA (2009) Coat variation in the domestic dog is governed by variants in three genes. Science. 326:150\u2013153","journal-title":"Science."},{"key":"62_CR7","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1111\/j.1474-9726.2008.00407.x","volume":"7","author":"CC Caldeira da Silva","year":"2008","unstructured":"Caldeira da Silva CC, Cerqueira FM, Barbosa LF, Medeiros MH, Kowaltowski AJ (2008) Mild mitochondrial uncoupling in mice affects energy metabolism, redox balance and longevity. Aging Cell 7:552\u2013560","journal-title":"Aging Cell"},{"key":"62_CR8","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1038\/jid.2013.352","volume":"134","author":"SY Cho","year":"2014","unstructured":"Cho SY, Seo DB, Kim WG, Lee SJ (2014) Mild mitochondrial uncoupling prevents premature senescence in human dermal fibroblasts. J Invest Dermatol 134:540\u2013543","journal-title":"J Invest Dermatol"},{"key":"62_CR9","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1007\/s10495-017-1412-0","volume":"22","author":"S Domanskyi","year":"2017","unstructured":"Domanskyi S, Nicholatos JW, Schilling JE, Privman V, Libert S (2017) SIRT6 knockout cells resist apoptosis initiation but not progression: a computational method to evaluate the progression of apoptosis. Apoptosis. 22:1336\u20131343","journal-title":"Apoptosis."},{"key":"62_CR10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000034","volume":"4","author":"CT Ferrara","year":"2008","unstructured":"Ferrara CT, Wang P, Neto EC, Stevens RD, Bain JR, Wenner BR, Ilkayeva OR, Keller MP, Blasiole DA, Kendziorski C, Yandell BS, Newgard CB, Attie AD (2008) Genetic networks of liver metabolism revealed by integration of metabolic and transcriptional profiling. PLoS Genet 4:e1000034","journal-title":"PLoS Genet"},{"key":"62_CR11","doi-asserted-by":"publisher","first-page":"1530","DOI":"10.1016\/j.celrep.2012.11.021","volume":"2","author":"LJ Fick","year":"2012","unstructured":"Fick LJ, Fick GH, Li Z, Cao E, Bao B, Heffelfinger D, Parker HG, Ostrander EA, Riabowol K (2012) Telomere length correlates with life span of dog breeds. Cell Rep 2:1530\u20131536","journal-title":"Cell Rep"},{"key":"62_CR12","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.rvsc.2006.06.005","volume":"82","author":"KA Greer","year":"2007","unstructured":"Greer KA, Canterberry SC, Murphy KE (2007) Statistical analysis regarding the effects of height and weight on life span of the domestic dog. Res Vet Sci 82:208\u2013214","journal-title":"Res Vet Sci"},{"key":"62_CR13","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1007\/s11357-010-9182-4","volume":"33","author":"KA Greer","year":"2011","unstructured":"Greer KA, Hughes LM, Masternak MM (2011) Connecting serum IGF-1, body size, and age in the domestic dog. Age (Dordr) 33:475\u2013483","journal-title":"Age (Dordr)"},{"key":"62_CR14","doi-asserted-by":"publisher","first-page":"1902","DOI":"10.1242\/jeb.054643","volume":"214","author":"JM Harper","year":"2011","unstructured":"Harper JM, Wang M, Galecki AT, Ro J, Williams JB, Miller RA (2011) Fibroblasts from long-lived bird species are resistant to multiple forms of stress. J Exp Biol 214:1902\u20131910","journal-title":"J Exp Biol"},{"key":"62_CR15","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10460","volume":"7","author":"JJ Hayward","year":"2016","unstructured":"Hayward JJ, Castelhano MG, Oliveira KC, Corey E, Balkman C, Baxter TL, Casal ML, Center SA, Fang M, Garrison SJ, Kalla SE, Korniliev P, Kotlikoff MI, Moise NS, Shannon LM, Simpson KW, Sutter NB, Todhunter RJ, Boyko AR (2016) Complex disease and phenotype mapping in the domestic dog. Nat Commun 7:10460","journal-title":"Nat Commun"},{"key":"62_CR16","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1111\/acel.12413","volume":"15","author":"A Hoeflich","year":"2016","unstructured":"Hoeflich A, Reyer A, Ohde D, Schindler N, Brenmoehl J, Spitschak M, Langhammer M, Tuchscherer A, Wirthgen E, Renner-Muller I, Wanke R, Metzger F, Bielohuby M, Wolf E (2016) Dissociation of somatic growth, time of sexual maturity, and life expectancy by overexpression of an RGD-deficient IGFBP-2 variant in female transgenic mice. Aging Cell 15:111\u2013117","journal-title":"Aging Cell"},{"key":"62_CR17","doi-asserted-by":"crossref","unstructured":"Hoffman JM, Creevy KE, Franks A, O'Neill DG, Promislow DEL (2018) The companion dog as a model for human aging and mortality. Aging Cell 17:e12737","DOI":"10.1111\/acel.12737"},{"key":"62_CR18","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1111\/j.1365-2052.2006.01448.x","volume":"37","author":"DJE Housley","year":"2006","unstructured":"Housley DJE, Venta PJ (2006) The long and the short of it: evidence that FGF5 is a major determinant of canine \u2018hair\u2019-itability. Anim Genet 37:309\u2013315","journal-title":"Anim Genet"},{"key":"62_CR19","doi-asserted-by":"publisher","first-page":"22342","DOI":"10.1074\/jbc.M604350200","volume":"281","author":"MV Jensen","year":"2006","unstructured":"Jensen MV, Joseph JW, Ilkayeva O, Burgess S, Lu D, Ronnebaum SM, Odegaard M, Becker TC, Sherry AD, Newgard CB (2006) Compensatory responses to pyruvate carboxylase suppression in islet beta-cells. Preservation of glucose-stimulated insulin secretion. J Biol Chem 281:22342\u201322351","journal-title":"J Biol Chem"},{"key":"62_CR20","doi-asserted-by":"crossref","unstructured":"Jimenez AG, Winward J, Beattie U, Cipolli W (2018) Cellular metabolism and oxidative stress as a possible determinant for longevity in small breed and large breed dogs. PLoS One 13:e0195832","DOI":"10.1371\/journal.pone.0195832"},{"key":"62_CR21","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/s00335-016-9638-7","volume":"27","author":"M Kaeberlein","year":"2016","unstructured":"Kaeberlein M, Creevy KE, Promislow DE (2016) The dog aging project: translational geroscience in companion animals. Mamm Genome 27:279\u2013288","journal-title":"Mamm Genome"},{"key":"62_CR22","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1086\/669665","volume":"181","author":"C Kraus","year":"2013","unstructured":"Kraus C, Pavard S, Promislow DE (2013) The size-life span trade-off decomposed: why large dogs die young. Am Nat 181:492\u2013505","journal-title":"Am Nat"},{"key":"62_CR23","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1007\/s11306-016-0997-6","volume":"12","author":"AJ Lloyd","year":"2016","unstructured":"Lloyd AJ, Beckmann M, Tailliart K, Brown WY, Draper J, Allaway D (2016) Characterisation of the main drivers of intra- and inter- breed variability in the plasma metabolome of dogs. Metabolomics. 12:72","journal-title":"Metabolomics."},{"key":"62_CR24","doi-asserted-by":"crossref","unstructured":"Lloyd AJ, Beckmann M, Wilson T, Tailliart K, Allaway D, Draper J (2017) Ultra high performance liquid chromatography-high resolution mass spectrometry plasma lipidomics can distinguish between canine breeds despite uncontrolled environmental variability and non-standardized diets. Metabolomics 13:15","DOI":"10.1007\/s11306-016-1152-0"},{"key":"62_CR25","doi-asserted-by":"publisher","first-page":"E990","DOI":"10.1152\/ajpendo.00602.2014","volume":"308","author":"CS McCoin","year":"2015","unstructured":"McCoin CS, Knotts TA, Ono-Moore KD, Oort PJ, Adams SH (2015) Long-chain acylcarnitines activate cell stress and myokine release in C2C12 myotubes: calcium-dependent and -independent effects. Am J Physiol Endocrinol Metab 308:E990\u2013E1000","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"62_CR26","doi-asserted-by":"publisher","first-page":"W566","DOI":"10.1093\/nar\/gkv468","volume":"43","author":"T Metsalu","year":"2015","unstructured":"Metsalu T, Vilo J (2015) ClustVis: a web tool for visualizing clustering of multivariate data using principal component analysis and heatmap. Nucleic Acids Res 43:W566\u2013W570","journal-title":"Nucleic Acids Res"},{"key":"62_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/4535710","volume":"2017","author":"RP Middleton","year":"2017","unstructured":"Middleton RP, Lacroix S, Scott-Boyer MP, Dordevic N, Kennedy AD, Slusky AR, Carayol J, Petzinger-Germain C, Beloshapka A, Kaput J (2017) Metabolic differences between dogs of different body sizes. J Nutr Metab 2017:1\u201311","journal-title":"J Nutr Metab"},{"key":"62_CR28","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.mad.2010.03.010","volume":"131","author":"SA Mookerjee","year":"2010","unstructured":"Mookerjee SA, Divakaruni AS, Jastroch M, Brand MD (2010) Mitochondrial uncoupling and lifespan. Mech Ageing Dev 131:463\u2013472","journal-title":"Mech Ageing Dev"},{"key":"62_CR29","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1096\/fj.02-1092fje","volume":"17","author":"S Murakami","year":"2003","unstructured":"Murakami S, Salmon A, Miller RA (2003) Multiplex stress resistance in cells from long-lived dwarf mice. FASEB J 17:1565\u20131566","journal-title":"FASEB J"},{"key":"62_CR30","volume-title":"Nutrient requirements of dogs and cats","author":"National Research Council (U.S.). Ad Hoc Committee on Dog and Cat Nutrition","year":"2006","unstructured":"National Research Council (U.S.). Ad Hoc Committee on Dog and Cat Nutrition (2006) Nutrient requirements of dogs and cats. National Academies Press, Washington, D.C"},{"key":"62_CR31","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/j.cmet.2018.02.019","volume":"27","author":"LM Redman","year":"2018","unstructured":"Redman LM, Smith SR, Burton JH, Martin CK, Il\u2019yasova D, Ravussin E (2018) Metabolic slowing and reduced oxidative damage with sustained caloric restriction support the rate of living and oxidative damage theories of aging. Cell Metab 27:805\u2013815 e804","journal-title":"Cell Metab"},{"key":"62_CR32","doi-asserted-by":"crossref","unstructured":"Rose G, Crocco P, De Rango F, Montesanto A, Passarino G (2011) Further support to the uncoupling-to-survive theory: the genetic variation of human UCP genes is associated with longevity. PLoS One 6:e29650","DOI":"10.1371\/journal.pone.0029650"},{"key":"62_CR33","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1111\/acel.12640","volume":"16","author":"SL Sanderson","year":"2017","unstructured":"Sanderson SL, Simon AK (2017) In aged primary T cells, mitochondrial stress contributes to telomere attrition measured by a novel imaging flow cytometry assay. Aging Cell 16:1234\u20131243","journal-title":"Aging Cell"},{"key":"62_CR34","doi-asserted-by":"publisher","first-page":"13639","DOI":"10.1073\/pnas.1516215112","volume":"112","author":"LM Shannon","year":"2015","unstructured":"Shannon LM, Boyko RH, Castelhano M, Corey E, Hayward JJ, McLean C, White ME, Abi Said M, Anita BA, Bondjengo NI, Calero J, Galov A, Hedimbi M, Imam B, Khalap R, Lally D, Masta A, Oliveira KC, Perez L, Randall J, Tam NM, Trujillo-Cornejo FJ, Valeriano C, Sutter NB, Todhunter RJ, Bustamante CD, Boyko AR (2015) Genetic structure in village dogs reveals a Central Asian domestication origin. Proc Natl Acad Sci U S A 112:13639\u201313644","journal-title":"Proc Natl Acad Sci U S A"},{"key":"62_CR35","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1046\/j.1474-9728.2003.00061.x","volume":"2","author":"JR Speakman","year":"2003","unstructured":"Speakman JR, van Acker A, Harper EJ (2003) Age-related changes in the metabolism and body composition of three dog breeds and their relationship to life expectancy. Aging Cell 2:265\u2013275","journal-title":"Aging Cell"},{"key":"62_CR36","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1111\/j.1474-9728.2004.00097.x","volume":"3","author":"JR Speakman","year":"2004","unstructured":"Speakman JR, Talbot DA, Selman C, Snart S, McLaren JS, Redman P, Krol E, Jackson DM, Johnson MS, Brand MD (2004) Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longer. Aging Cell 3:87\u201395","journal-title":"Aging Cell"},{"key":"62_CR37","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.cmet.2015.11.002","volume":"23","author":"M Sukumar","year":"2016","unstructured":"Sukumar M, Liu J, Mehta GU, Patel SJ, Roychoudhuri R, Crompton JG, Klebanoff CA, Ji Y, Li P, Yu Z, Whitehill GD, Clever D, Eil RL, Palmer DC, Mitra S, Rao M, Keyvanfar K, Schrump DS, Wang E, Marincola FM, Gattinoni L, Leonard WJ, Muranski P, Finkel T, Restifo NP (2016) Mitochondrial membrane potential identifies cells with enhanced stemness for cellular therapy. Cell Metab 23:63\u201376","journal-title":"Cell Metab"},{"key":"62_CR38","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1126\/science.1137045","volume":"316","author":"NB Sutter","year":"2007","unstructured":"Sutter NB, Bustamante CD, Chase K, Gray MM, Zhao KY, Zhu L, Padhukasahasram B, Karlins E, Davis S, Jones PG, Quignon P, Johnson GS, Parker HG, Fretwell N, Mosher DS, Lawler DF, Satyaraj E, Nordborg M, Lark KG, Wayne RK, Ostrander EA (2007) A single IGF1 allele is a major determinant of small size in dogs. Science. 316:112\u2013115","journal-title":"Science."},{"key":"62_CR39","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1111\/j.1474-9726.2012.00833.x","volume":"11","author":"M Wang","year":"2012","unstructured":"Wang M, Miller RA (2012) Fibroblasts from long-lived mutant mice exhibit increased autophagy and lower TOR activity after nutrient deprivation or oxidative stress. Aging Cell 11:668\u2013674","journal-title":"Aging Cell"},{"key":"62_CR40","doi-asserted-by":"publisher","first-page":"1860","DOI":"10.1038\/ncomms2814","volume":"4","author":"GD Wang","year":"2013","unstructured":"Wang GD, Zhai W, Yang HC, Fan RX, Cao X, Zhong L, Wang L, Liu F, Wu H, Cheng LG, Poyarkov AD, Poyarkov NA Jr, Tang SS, Zhao WM, Gao Y, Lv XM, Irwin DM, Savolainen P, Wu CI, Zhang YP (2013) The genomics of selection in dogs and the parallel evolution between dogs and humans. Nat Commun 4:1860","journal-title":"Nat Commun"}],"container-title":["GeroScience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11357-019-00062-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11357-019-00062-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11357-019-00062-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T21:35:31Z","timestamp":1589664931000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11357-019-00062-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["62"],"URL":"https:\/\/doi.org\/10.1007\/s11357-019-00062-6","relation":{},"ISSN":["2509-2715","2509-2723"],"issn-type":[{"value":"2509-2715","type":"print"},{"value":"2509-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"2 November 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}