{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:25:02Z","timestamp":1792081502471,"version":"4.4.0"},"reference-count":111,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T00:00:00Z","timestamp":1567555200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T00:00:00Z","timestamp":1567555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG059190"],"award-info":[{"award-number":["AG059190"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG059846"],"award-info":[{"award-number":["AG059846"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG13925"],"award-info":[{"award-number":["AG13925"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG041122"],"award-info":[{"award-number":["AG041122"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["AG030979"],"award-info":[{"award-number":["AG030979"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["GeroScience"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1007\/s11357-019-00096-w","type":"journal-article","created":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T06:13:02Z","timestamp":1567577582000},"page":"759-774","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["The enigmatic role of growth hormone in age-related diseases, cognition, and longevity"],"prefix":"10.1007","volume":"41","author":[{"given":"Gabriela","family":"Colon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Saccon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusto","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo B.","family":"Cavalcante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek M.","family":"Huffman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darlene","family":"Berryman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ed","family":"List","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Ikeno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Musi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Bartke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Kopchick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Kirkland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Tchkonia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal M.","family":"Masternak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,9,4]]},"reference":[{"issue":"2","key":"96_CR1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1210\/er.2018-00216","volume":"40","author":"MH Aguiar-Oliveira","year":"2019","unstructured":"Aguiar-Oliveira MH, Bartke A (2019) Growth hormone deficiency: health and longevity. Endocr Rev 40(2):575\u2013601","journal-title":"Endocr Rev"},{"issue":"2","key":"96_CR2","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1210\/jcem.84.2.5455","volume":"84","author":"A Aleman","year":"1999","unstructured":"Aleman A et al (1999) Insulin-like growth factor-I and cognitive function in healthy older men. J Clin Endocrinol Metab 84(2):471\u2013475","journal-title":"J Clin Endocrinol Metab"},{"key":"96_CR3","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.exger.2014.10.002","volume":"68","author":"NM Ashpole","year":"2015","unstructured":"Ashpole NM et al (2015) Growth hormone, insulin-like growth factor-1 and the aging brain. Exp Gerontol 68:76\u201381","journal-title":"Exp Gerontol"},{"issue":"2","key":"96_CR4","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s11357-017-9971-0","volume":"39","author":"NM Ashpole","year":"2017","unstructured":"Ashpole NM et al (2017) IGF-1 has sexually dimorphic, pleiotropic, and time-dependent effects on healthspan, pathology, and lifespan. Geroscience 39(2):129\u2013145","journal-title":"Geroscience"},{"issue":"11","key":"96_CR5","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1001\/archneurol.2012.1970","volume":"69","author":"LD Baker","year":"2012","unstructured":"Baker LD et al (2012) Effects of growth hormone-releasing hormone on cognitive function in adults with mild cognitive impairment and healthy older adults: results of a controlled trial. Arch Neurol 69(11):1420\u20131429","journal-title":"Arch Neurol"},{"issue":"1","key":"96_CR6","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s11357-018-0048-5","volume":"41","author":"P Balasubramanian","year":"2019","unstructured":"Balasubramanian P, Hall D, Subramanian M (2019) Sympathetic nervous system as a target for aging and obesity-related cardiovascular diseases. Geroscience 41(1):13\u201324","journal-title":"Geroscience"},{"issue":"9","key":"96_CR7","doi-asserted-by":"crossref","first-page":"3718","DOI":"10.1210\/en.2005-0411","volume":"146","author":"A Bartke","year":"2005","unstructured":"Bartke A (2005) Minireview: role of the growth hormone\/insulin-like growth factor system in mammalian aging. Endocrinology 146(9):3718\u20133723","journal-title":"Endocrinology"},{"issue":"4","key":"96_CR8","doi-asserted-by":"crossref","first-page":"659","DOI":"10.2147\/CIA.S3697","volume":"3","author":"A Bartke","year":"2008","unstructured":"Bartke A (2008) Growth hormone and aging: a challenging controversy. Clin Interv Aging 3(4):659\u2013665","journal-title":"Clin Interv Aging"},{"key":"96_CR9","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41514-017-0014-y","volume":"3","author":"A Bartke","year":"2017","unstructured":"Bartke A (2017) Somatic growth, aging, and longevity. NPJ Aging Mech Dis 3:14","journal-title":"NPJ Aging Mech Dis"},{"issue":"1","key":"96_CR10","doi-asserted-by":"crossref","first-page":"19","DOI":"10.5534\/wjmh.180018","volume":"37","author":"A Bartke","year":"2019","unstructured":"Bartke A (2019) Growth hormone and aging: updated review. World J Mens Health 37(1):19\u201330","journal-title":"World J Mens Health"},{"issue":"5","key":"96_CR11","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1210\/en.2015-1097","volume":"156","author":"A Bartke","year":"2015","unstructured":"Bartke A, Kopchick JJ (2015) The forgotten lactogenic activity of growth hormone: important implications for rodent studies. Endocrinology 156(5):1620\u20131622","journal-title":"Endocrinology"},{"key":"96_CR12","doi-asserted-by":"crossref","first-page":"288","DOI":"10.3389\/fgene.2012.00288","volume":"3","author":"A Bartke","year":"2012","unstructured":"Bartke A, Westbrook R (2012) Metabolic characteristics of long-lived mice. Front Genet 3:288","journal-title":"Front Genet"},{"issue":"6862","key":"96_CR13","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/35106646","volume":"414","author":"A Bartke","year":"2001","unstructured":"Bartke A et al (2001) Extending the lifespan of long-lived mice. Nature 414(6862):412","journal-title":"Nature"},{"key":"96_CR14","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.yhbeh.2017.04.001","volume":"93","author":"A Basu","year":"2017","unstructured":"Basu A, McFarlane HG, Kopchick JJ (2017) Spatial learning and memory in male mice with altered growth hormone action. Horm Behav 93:18\u201330","journal-title":"Horm Behav"},{"issue":"9","key":"96_CR15","first-page":"3184","volume":"83","author":"HB Baum","year":"1998","unstructured":"Baum HB et al (1998) Effects of physiological growth hormone (GH) therapy on cognition and quality of life in patients with adult-onset GH deficiency. J Clin Endocrinol Metab 83(9):3184\u20133189","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"96_CR16","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1602025","volume":"3","author":"D Ben-Avraham","year":"2017","unstructured":"Ben-Avraham D et al (2017) The GH receptor exon 3 deletion is a marker of male-specific exceptional longevity associated with increased GH sensitivity and taller stature. Sci Adv 3(6):e1602025","journal-title":"Sci Adv"},{"issue":"1","key":"96_CR17","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s11357-017-9957-y","volume":"39","author":"MT Bennis","year":"2017","unstructured":"Bennis MT et al (2017) The role of transplanted visceral fat from the long-lived growth hormone receptor knockout mice on insulin signaling. Geroscience 39(1):51\u201359","journal-title":"Geroscience"},{"issue":"8","key":"96_CR18","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.3390\/ijms18081621","volume":"18","author":"Darlene Berryman","year":"2017","unstructured":"Berryman DE, List EO (2017) Growth hormone\u2019s effect on adipose tissue: quality versus quantity. Int J Mol Sci 18(8)","journal-title":"International Journal of Molecular Sciences"},{"issue":"4","key":"96_CR19","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.ghir.2004.02.005","volume":"14","author":"DE Berryman","year":"2004","unstructured":"Berryman DE et al (2004) Comparing adiposity profiles in three mouse models with altered GH signaling. Growth Hormon IGF Res 14(4):309\u2013318","journal-title":"Growth Hormon IGF Res"},{"issue":"1","key":"96_CR20","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/gerona\/glp175","volume":"65","author":"DE Berryman","year":"2010","unstructured":"Berryman DE et al (2010) Two-year body composition analyses of long-lived GHR null mice. J Gerontol A Biol Sci Med Sci 65(1):31\u201340","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"8","key":"96_CR21","doi-asserted-by":"crossref","first-page":"3664","DOI":"10.1210\/jc.2002-021938","volume":"88","author":"A Besson","year":"2003","unstructured":"Besson A et al (2003) Reduced longevity in untreated patients with isolated growth hormone deficiency. J Clin Endocrinol Metab 88(8):3664\u20133667","journal-title":"J Clin Endocrinol Metab"},{"issue":"18","key":"96_CR22","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1001\/jama.288.18.2282","volume":"288","author":"MR Blackman","year":"2002","unstructured":"Blackman MR et al (2002) Growth hormone and sex steroid administration in healthy aged women and men: a randomized controlled trial. JAMA 288(18):2282\u20132292","journal-title":"JAMA"},{"issue":"4","key":"96_CR23","first-page":"414","volume":"67","author":"CL Boguszewski","year":"2016","unstructured":"Boguszewski CL, Boguszewski MC, Kopchick JJ (2016) Growth hormone, insulin-like growth factor system and carcinogenesis. Endokrynol Pol 67(4):414\u2013426","journal-title":"Endokrynol Pol"},{"issue":"2","key":"96_CR24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0004567","volume":"4","author":"MS Bonkowski","year":"2009","unstructured":"Bonkowski MS et al (2009) Disruption of growth hormone receptor prevents calorie restriction from improving insulin action and longevity. PLoS One 4(2):e4567","journal-title":"PLoS One"},{"key":"96_CR25","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1186\/1756-0500-7-813","volume":"7","author":"M Brod","year":"2014","unstructured":"Brod M et al (2014) Impact of adult growth hormone deficiency on daily functioning and well-being. BMC Res Notes 7:813","journal-title":"BMC Res Notes"},{"issue":"5","key":"96_CR26","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/j.1365-2265.1992.tb02347.x","volume":"37","author":"RC Cuneo","year":"1992","unstructured":"Cuneo RC et al (1992) The growth hormone deficiency syndrome in adults. Clin Endocrinol 37(5):387\u2013397","journal-title":"Clin Endocrinol"},{"issue":"1","key":"96_CR27","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1080\/21623945.2016.1274470","volume":"6","author":"J Darcy","year":"2017","unstructured":"Darcy J, Bartke A (2017) Functionally enhanced brown adipose tissue in Ames dwarf mice. Adipocyte 6(1):62\u201367","journal-title":"Adipocyte"},{"issue":"12","key":"96_CR28","doi-asserted-by":"crossref","first-page":"4744","DOI":"10.1210\/en.2016-1593","volume":"157","author":"J Darcy","year":"2016","unstructured":"Darcy J et al (2016) Brown adipose tissue function is enhanced in long-lived, male Ames dwarf mice. Endocrinology 157(12):4744\u20134753","journal-title":"Endocrinology"},{"key":"96_CR29","doi-asserted-by":"crossref","first-page":"47","DOI":"10.4137\/CMED.S38201","volume":"9","author":"J Devesa","year":"2016","unstructured":"Devesa J, Almenglo C, Devesa P (2016a) Multiple effects of growth hormone in the body: is it really the hormone for growth? Clin Med Insights Endocrinol Diabetes 9:47\u201371","journal-title":"Clin Med Insights Endocrinol Diabetes"},{"issue":"2","key":"96_CR30","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3390\/jcm5020014","volume":"5","author":"Jes\u00fas Devesa","year":"2016","unstructured":"Devesa J et al (2016b) Learning and memory recoveries in a young girl treated with growth hormone and neurorehabilitation. J Clin Med 5(2)","journal-title":"Journal of Clinical Medicine"},{"issue":"1","key":"96_CR31","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1677\/joe.0.1730081","volume":"173","author":"FP Dominici","year":"2002","unstructured":"Dominici FP et al (2002) Increased insulin sensitivity and upregulation of insulin receptor, insulin receptor substrate (IRS)-1 and IRS-2 in liver of Ames dwarf mice. J Endocrinol 173(1):81\u201394","journal-title":"J Endocrinol"},{"issue":"15","key":"96_CR32","doi-asserted-by":"crossref","first-page":"6031","DOI":"10.1073\/pnas.0507776103","volume":"103","author":"CP Donahue","year":"2006","unstructured":"Donahue CP, Kosik KS, Shors TJ (2006) Growth hormone is produced within the hippocampus where it responds to age, sex, and stress. Proc Natl Acad Sci U S A 103(15):6031\u20136036","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"96_CR33","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1073\/pnas.8.3.38","volume":"8","author":"HM Evans","year":"1922","unstructured":"Evans HM, Long JA (1922) Characteristic effects upon growth, oestrus and ovulation induced by the intraperitoneal administration of fresh anterior hypophyseal substance. Proc Natl Acad Sci U S A 8(3):38\u201339","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"96_CR34","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s11357-019-00065-3","volume":"41","author":"GE Farias Quipildor","year":"2019","unstructured":"Farias Quipildor GE et al (2019) Central IGF-1 protects against features of cognitive and sensorimotor decline with aging in male mice. Geroscience 41(2):185\u2013208","journal-title":"Geroscience"},{"issue":"1","key":"96_CR35","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s12020-016-1047-x","volume":"54","author":"U Feldt-Rasmussen","year":"2016","unstructured":"Feldt-Rasmussen U, Klose M (2016) Central hypothyroidism and its role for cardiovascular risk factors in hypopituitary patients. Endocrine 54(1):15\u201323","journal-title":"Endocrine"},{"issue":"7","key":"96_CR36","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1001\/jamaneurol.2013.1425","volume":"70","author":"SD Friedman","year":"2013","unstructured":"Friedman SD et al (2013) Growth hormone-releasing hormone effects on brain gamma-aminobutyric acid levels in mild cognitive impairment and healthy aging. JAMA Neurol 70(7):883\u2013890","journal-title":"JAMA Neurol"},{"issue":"3","key":"96_CR37","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1046\/j.1365-2265.2002.01608.x","volume":"57","author":"FJ Gilchrist","year":"2002","unstructured":"Gilchrist FJ, Murray RD, Shalet SM (2002) The effect of long-term untreated growth hormone deficiency (GHD) and 9 years of GH replacement on the quality of life (QoL) of GH-deficient adults. Clin Endocrinol 57(3):363\u2013370","journal-title":"Clin Endocrinol"},{"issue":"70","key":"96_CR38","doi-asserted-by":"crossref","first-page":"70ra13","DOI":"10.1126\/scitranslmed.3001845","volume":"3","author":"J Guevara-Aguirre","year":"2011","unstructured":"Guevara-Aguirre J et al (2011) Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci Transl Med 3(70):70ra13","journal-title":"Sci Transl Med"},{"issue":"7","key":"96_CR39","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1210\/jc.2015-1678","volume":"100","author":"J Guevara-Aguirre","year":"2015","unstructured":"Guevara-Aguirre J et al (2015) GH receptor deficiency in Ecuadorian adults is associated with obesity and enhanced insulin sensitivity. J Clin Endocrinol Metab 100(7):2589\u20132596","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"96_CR40","first-page":"329","volume":"72","author":"KN Hascup","year":"2017","unstructured":"Hascup KN et al (2017) Enhanced cognition and hypoglutamatergic signaling in a growth hormone receptor knockout mouse model of successful aging. J Gerontol A Biol Sci Med Sci 72(3):329\u2013337","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"10","key":"96_CR41","doi-asserted-by":"crossref","first-page":"4765","DOI":"10.1210\/jcem.86.10.7897","volume":"86","author":"L Hulthen","year":"2001","unstructured":"Hulthen L et al (2001) GH is needed for the maturation of muscle mass and strength in adolescents. J Clin Endocrinol Metab 86(10):4765\u20134770","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"96_CR42","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1093\/gerona\/58.4.B291","volume":"58","author":"Y Ikeno","year":"2003","unstructured":"Ikeno Y et al (2003) Delayed occurrence of fatal neoplastic diseases in Ames dwarf mice: correlation to extended longevity. J Gerontol A Biol Sci Med Sci 58(4):291\u2013296","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"1","key":"96_CR43","first-page":"279","volume":"84","author":"YJ Janssen","year":"1999","unstructured":"Janssen YJ, Doornbos J, Roelfsema F (1999) Changes in muscle volume, strength, and bioenergetics during recombinant human growth hormone (GH) therapy in adults with GH deficiency. J Clin Endocrinol Metab 84(1):279\u2013284","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"96_CR44","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1210\/jcem.87.4.8394","volume":"87","author":"G Johannsson","year":"2002","unstructured":"Johannsson G et al (2002) GH increases extracellular volume by stimulating sodium reabsorption in the distal nephron and preventing pressure natriuresis. J Clin Endocrinol Metab 87(4):1743\u20131749","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"96_CR45","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1046\/j.1365-2265.1996.8720883.x","volume":"45","author":"JO Jorgensen","year":"1996","unstructured":"Jorgensen JO et al (1996) Growth hormone versus placebo treatment for one year in growth hormone deficient adults: increase in exercise capacity and normalization of body composition. Clin Endocrinol 45(6):681\u2013688","journal-title":"Clin Endocrinol"},{"issue":"12","key":"96_CR46","doi-asserted-by":"crossref","first-page":"4551","DOI":"10.1210\/jcem.85.12.7033","volume":"85","author":"S Kalmijn","year":"2000","unstructured":"Kalmijn S et al (2000) A prospective study on circulating insulin-like growth factor I (IGF-I), IGF-binding proteins, and cognitive function in the elderly. J Clin Endocrinol Metab 85(12):4551\u20134555","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"96_CR47","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S0031-9384(01)00423-1","volume":"72","author":"BA Kinney","year":"2001","unstructured":"Kinney BA et al (2001a) Evidence that age-induced decline in memory retention is delayed in growth hormone resistant GH-R-KO (Laron) mice. Physiol Behav 72(5):653\u2013660","journal-title":"Physiol Behav"},{"issue":"4","key":"96_CR48","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1006\/hbeh.2001.1654","volume":"39","author":"BA Kinney","year":"2001","unstructured":"Kinney BA et al (2001b) Evidence that Ames dwarf mice age differently from their normal siblings in behavioral and learning and memory parameters. Horm Behav 39(4):277\u2013284","journal-title":"Horm Behav"},{"key":"96_CR49","doi-asserted-by":"crossref","first-page":"365","DOI":"10.3389\/fnagi.2017.00365","volume":"9","author":"JL Labandeira-Garcia","year":"2017","unstructured":"Labandeira-Garcia JL et al (2017) Insulin-like growth factor-1 and neuroinflammation. Front Aging Neurosci 9:365","journal-title":"Front Aging Neurosci"},{"issue":"2","key":"96_CR50","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.mad.2004.08.022","volume":"126","author":"Z Laron","year":"2005","unstructured":"Laron Z (2005) Do deficiencies in growth hormone and insulin-like growth factor-1 (IGF-1) shorten or prolong longevity? Mech Ageing Dev 126(2):305\u2013307","journal-title":"Mech Ageing Dev"},{"issue":"10","key":"96_CR51","doi-asserted-by":"crossref","first-page":"7119","DOI":"10.1073\/pnas.092135399","volume":"99","author":"M Le Greves","year":"2002","unstructured":"Le Greves M et al (2002) Growth hormone induces age-dependent alteration in the expression of hippocampal growth hormone receptor and N-methyl-D-aspartate receptor subunits gene transcripts in male rats. Proc Natl Acad Sci U S A 99(10):7119\u20137123","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"96_CR52","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0306-4522(01)00378-5","volume":"107","author":"RJ Lichtenwalner","year":"2001","unstructured":"Lichtenwalner RJ et al (2001) Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis. Neuroscience 107(4):603\u2013613","journal-title":"Neuroscience"},{"key":"96_CR53","unstructured":"List EO, et al (2014) Liver-specific GH receptor gene disrupted (LiGHRKO) mice have decreased endocrine IGF-1, increased local IGF-1 as well as altered body size, body composition and adipokine profiles. Endocrinology en20132086"},{"issue":"262","key":"96_CR54","first-page":"145","volume":"70","author":"MD Littley","year":"1989","unstructured":"Littley MD et al (1989) Hypopituitarism following external radiotherapy for pituitary tumours in adults. Q J Med 70(262):145\u2013160","journal-title":"Q J Med"},{"issue":"2","key":"96_CR55","doi-asserted-by":"crossref","first-page":"104","DOI":"10.7326\/0003-4819-146-2-200701160-00005","volume":"146","author":"H Liu","year":"2007","unstructured":"Liu H et al (2007) Systematic review: the safety and efficacy of growth hormone in the healthy elderly. Ann Intern Med 146(2):104\u2013115","journal-title":"Ann Intern Med"},{"key":"96_CR56","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.molmet.2018.01.013","volume":"9","author":"S Logan","year":"2018","unstructured":"Logan S et al (2018) Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-beta uptake in astrocytes. Mol Metab 9:141\u2013155","journal-title":"Mol Metab"},{"issue":"1","key":"96_CR57","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1006\/dbio.2000.9975","volume":"229","author":"F Lupu","year":"2001","unstructured":"Lupu F et al (2001) Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth. Dev Biol 229(1):141\u2013162","journal-title":"Dev Biol"},{"issue":"3","key":"96_CR58","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S0306-4522(98)00143-2","volume":"87","author":"AL Markowska","year":"1998","unstructured":"Markowska AL, Mooney M, Sonntag WE (1998) Insulin-like growth factor-1 ameliorates age-related behavioral deficits. Neuroscience 87(3):559\u2013569","journal-title":"Neuroscience"},{"key":"96_CR59","doi-asserted-by":"crossref","unstructured":"Masternak MM, Bartke A (2012) Growth hormone, inflammation and aging. Pathobiol Aging Age Relat Dis. 2","DOI":"10.3402\/pba.v2i0.17293"},{"issue":"8","key":"96_CR60","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1093\/gerona\/59.8.B784","volume":"59","author":"MM Masternak","year":"2004","unstructured":"Masternak MM et al (2004) Divergent effects of caloric restriction on gene expression in normal and long-lived mice. J Gerontol A Biol Sci Med Sci 59(8):784\u2013788","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"1","key":"96_CR61","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1474-9726.2011.00763.x","volume":"11","author":"MM Masternak","year":"2012","unstructured":"Masternak MM et al (2012) Metabolic effects of intra-abdominal fat in GHRKO mice. Aging Cell 11(1):73\u201381","journal-title":"Aging Cell"},{"key":"96_CR62","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/bs.pmbts.2017.12.002","volume":"155","author":"MM Masternak","year":"2018","unstructured":"Masternak MM et al (2018) Dwarf mice and aging. Prog Mol Biol Transl Sci 155:69\u201383","journal-title":"Prog Mol Biol Transl Sci"},{"key":"96_CR63","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/acel.12201","volume":"13","author":"V Menon","year":"2014","unstructured":"Menon V et al (2014) The contribution of visceral fat to improved insulin signaling in Ames dwarf mice. Aging Cell 13:497\u2013506","journal-title":"Aging Cell"},{"issue":"5","key":"96_CR64","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1530\/eje.0.1350553","volume":"135","author":"B Merola","year":"1996","unstructured":"Merola B et al (1996) Lung volumes and respiratory muscle strength in adult patients with childhood- or adult-onset growth hormone deficiency: effect of 12 months\u2019 growth hormone replacement therapy. Eur J Endocrinol 135(5):553\u2013558","journal-title":"Eur J Endocrinol"},{"issue":"9\u201310","key":"96_CR65","first-page":"813","volume":"27","author":"J Modesto Mde","year":"2014","unstructured":"Modesto Mde J et al (2014) Muscle strength and body composition during the transition phase in patients treated with recombinant GH to final height. J Pediatr Endocrinol Metab 27(9\u201310):813\u2013820","journal-title":"J Pediatr Endocrinol Metab"},{"issue":"5","key":"96_CR66","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1046\/j.1365-2265.1996.728550.x","volume":"44","author":"J Moller","year":"1996","unstructured":"Moller J et al (1996) Decreased plasma and extracellular volume in growth hormone deficient adults and the acute and prolonged effects of GH administration: a controlled experimental study. Clin Endocrinol 44(5):533\u2013539","journal-title":"Clin Endocrinol"},{"key":"96_CR67","doi-asserted-by":"crossref","unstructured":"Murray PG, Clayton PE (2000) Disorders of growth hormone in childhood","DOI":"10.1159\/000023529"},{"issue":"7","key":"96_CR68","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1523\/JNEUROSCI.1929-16.2016","volume":"37","author":"K Nashiro","year":"2017","unstructured":"Nashiro K et al (2017) Brain structure and function associated with younger adults in growth hormone receptor-deficient humans. J Neurosci 37(7):1696\u20131707","journal-title":"J Neurosci"},{"issue":"9","key":"96_CR69","doi-asserted-by":"crossref","first-page":"601","DOI":"10.7326\/0003-4819-149-9-200811040-00003","volume":"149","author":"R Nass","year":"2008","unstructured":"Nass R et al (2008) Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial. Ann Intern Med 149(9):601\u2013611","journal-title":"Ann Intern Med"},{"issue":"10","key":"96_CR70","doi-asserted-by":"crossref","first-page":"3913","DOI":"10.1210\/jc.2009-0452","volume":"94","author":"I Netchine","year":"2009","unstructured":"Netchine I et al (2009) Partial primary deficiency of insulin-like growth factor (IGF)-I activity associated with IGF1 mutation demonstrates its critical role in growth and brain development. J Clin Endocrinol Metab 94(10):3913\u20133921","journal-title":"J Clin Endocrinol Metab"},{"issue":"26","key":"96_CR71","first-page":"1260","volume":"177","author":"J Nielsen","year":"2015","unstructured":"Nielsen J, Jensen RB, Afdeling AJ (2015) Growth hormone deficiency in children. Ugeskr Laeger 177(26):1260\u20131263","journal-title":"Ugeskr Laeger"},{"issue":"4","key":"96_CR72","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1006\/frne.2000.0200","volume":"21","author":"F Nyberg","year":"2000","unstructured":"Nyberg F (2000) Growth hormone in the brain: characteristics of specific brain targets for the hormone and their functional significance. Front Neuroendocrinol 21(4):330\u2013348","journal-title":"Front Neuroendocrinol"},{"issue":"11","key":"96_CR73","doi-asserted-by":"crossref","first-page":"4898","DOI":"10.1210\/en.2005-0587","volume":"146","author":"W Pan","year":"2005","unstructured":"Pan W et al (2005) Permeation of growth hormone across the blood-brain barrier. Endocrinology 146(11):4898\u20134904","journal-title":"Endocrinology"},{"issue":"7","key":"96_CR74","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1210\/jcem.82.7.4087","volume":"82","author":"G Paolisso","year":"1997","unstructured":"Paolisso G et al (1997) Serum levels of insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 in healthy centenarians: relationship with plasma leptin and lipid concentrations, insulin action, and cognitive function. J Clin Endocrinol Metab 82(7):2204\u20132209","journal-title":"J Clin Endocrinol Metab"},{"issue":"16","key":"96_CR75","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1001\/jama.294.16.2086","volume":"294","author":"TT Perls","year":"2005","unstructured":"Perls TT, Reisman NR, Olshansky SJ (2005) Provision or distribution of growth hormone for \u201cantiaging\u201d: clinical and legal issues. JAMA 294(16):2086\u20132090","journal-title":"JAMA"},{"issue":"2","key":"96_CR76","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s11357-017-9966-x","volume":"39","author":"A Podlutsky","year":"2017","unstructured":"Podlutsky A et al (2017) The GH\/IGF-1 axis in a critical period early in life determines cellular DNA repair capacity by altering transcriptional regulation of DNA repair-related genes: implications for the developmental origins of cancer. Geroscience 39(2):147\u2013160","journal-title":"Geroscience"},{"key":"96_CR77","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.psyneuen.2017.09.018","volume":"86","author":"P Quinlan","year":"2017","unstructured":"Quinlan P et al (2017) Low serum insulin-like growth factor-I (IGF-I) level is associated with increased risk of vascular dementia. Psychoneuroendocrinology 86:169\u2013175","journal-title":"Psychoneuroendocrinology"},{"issue":"1","key":"96_CR78","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.neuroscience.2004.08.001","volume":"129","author":"MM Ramsey","year":"2004","unstructured":"Ramsey MM et al (2004) Growth hormone treatment attenuates age-related changes in hippocampal short-term plasticity and spatial learning. Neuroscience 129(1):119\u2013127","journal-title":"Neuroscience"},{"issue":"8","key":"96_CR79","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1111\/j.0953-816X.2004.03308.x","volume":"19","author":"MI Ransome","year":"2004","unstructured":"Ransome MI et al (2004) Comparative analysis of CNS populations in knockout mice with altered growth hormone responsiveness. Eur J Neurosci 19(8):2069\u20132079","journal-title":"Eur J Neurosci"},{"issue":"22","key":"96_CR80","doi-asserted-by":"crossref","first-page":"4528","DOI":"10.1093\/hmg\/ddt300","volume":"22","author":"M Renna","year":"2013","unstructured":"Renna M et al (2013) IGF-1 receptor antagonism inhibits autophagy. Hum Mol Genet 22(22):4528\u20134544","journal-title":"Hum Mol Genet"},{"issue":"1","key":"96_CR81","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM199007053230101","volume":"323","author":"D Rudman","year":"1990","unstructured":"Rudman D et al (1990) Effects of human growth hormone in men over 60 years old. N Engl J Med 323(1):1\u20136","journal-title":"N Engl J Med"},{"issue":"1","key":"96_CR82","first-page":"273","volume":"86","author":"R Salvatori","year":"2001","unstructured":"Salvatori R et al (2001) Three new mutations in the gene for the growth hormone (gh)-releasing hormone receptor in familial isolated gh deficiency type ib. J Clin Endocrinol Metab 86(1):273\u2013279","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"96_CR83","first-page":"119","volume":"25","author":"A Sanz","year":"2002","unstructured":"Sanz A, Bartke A, Barja G (2002) Long-lived Ames dwarf mice: oxidative damage to mitochondrial DNA in heart and brain. J Am Aging Assoc 25(3):119\u2013122","journal-title":"J Am Aging Assoc"},{"issue":"4","key":"96_CR84","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1530\/eje.1.02346","volume":"156","author":"M Sathiavageeswaran","year":"2007","unstructured":"Sathiavageeswaran M et al (2007) Effects of GH on cognitive function in elderly patients with adult-onset GH deficiency: a placebo-controlled 12-month study. Eur J Endocrinol 156(4):439\u2013447","journal-title":"Eur J Endocrinol"},{"issue":"21","key":"96_CR85","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1212\/01.wnl.0000335163.88054.e7","volume":"71","author":"JJ Sevigny","year":"2008","unstructured":"Sevigny JJ et al (2008) Growth hormone secretagogue MK-677: no clinical effect on AD progression in a randomized trial. Neurology 71(21):1702\u20131708","journal-title":"Neurology"},{"issue":"1","key":"96_CR86","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ghir.2006.10.007","volume":"17","author":"O Shevah","year":"2007","unstructured":"Shevah O, Laron Z (2007) Patients with congenital deficiency of IGF-I seem protected from the development of malignancies: a preliminary report. Growth Hormon IGF Res 17(1):54\u201357","journal-title":"Growth Hormon IGF Res"},{"issue":"4","key":"96_CR87","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1054\/clnu.2001.0398","volume":"20","author":"JA Simpson","year":"2001","unstructured":"Simpson JA et al (2001) Body water compartment measurements: a comparison of bioelectrical impedance analysis with tritium and sodium bromide dilution techniques. Clin Nutr 20(4):339\u2013343","journal-title":"Clin Nutr"},{"issue":"6","key":"96_CR88","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1210\/endo-107-6-1875","volume":"107","author":"WE Sonntag","year":"1980","unstructured":"Sonntag WE et al (1980) Decreased pulsatile release of growth hormone in old male rats. Endocrinology 107(6):1875\u20131879","journal-title":"Endocrinology"},{"issue":"2","key":"96_CR89","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1159\/000123205","volume":"33","author":"WE Sonntag","year":"1981","unstructured":"Sonntag WE et al (1981) Effects of CNS active drugs and somatostatin antiserum on growth hormone release in young and old male rats. Neuroendocrinology 33(2):73\u201378","journal-title":"Neuroendocrinology"},{"issue":"Pt 4","key":"96_CR90","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1017\/S002187829900713X","volume":"197","author":"WE Sonntag","year":"2000","unstructured":"Sonntag WE et al (2000) The effects of growth hormone and IGF-1 deficiency on cerebrovascular and brain ageing. J Anat 197(Pt 4):575\u2013585","journal-title":"J Anat"},{"issue":"2","key":"96_CR91","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.arr.2005.02.001","volume":"4","author":"WE Sonntag","year":"2005","unstructured":"Sonntag WE, Ramsey M, Carter CS (2005) Growth hormone and insulin-like growth factor-1 (IGF-1) and their influence on cognitive aging. Ageing Res Rev 4(2):195\u2013212","journal-title":"Ageing Res Rev"},{"issue":"6","key":"96_CR92","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1093\/gerona\/gls115","volume":"67","author":"WE Sonntag","year":"2012","unstructured":"Sonntag WE et al (2012) Diverse roles of growth hormone and insulin-like growth factor-1 in mammalian aging: progress and controversies. J Gerontol A Biol Sci Med Sci 67(6):587\u2013598","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"96_CR93","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3389\/fnagi.2013.00027","volume":"5","author":"WE Sonntag","year":"2013","unstructured":"Sonntag WE et al (2013) Insulin-like growth factor-1 in CNS and cerebrovascular aging. Front Aging Neurosci 5:27","journal-title":"Front Aging Neurosci"},{"issue":"6","key":"96_CR94","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.neurobiolaging.2004.07.010","volume":"26","author":"LY Sun","year":"2005","unstructured":"Sun LY et al (2005a) Local expression of GH and IGF-1 in the hippocampus of GH-deficient long-lived mice. Neurobiol Aging 26(6):929\u2013937","journal-title":"Neurobiol Aging"},{"issue":"3","key":"96_CR95","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1210\/en.2004-1115","volume":"146","author":"LY Sun","year":"2005","unstructured":"Sun LY et al (2005b) Increased neurogenesis in dentate gyrus of long-lived Ames dwarf mice. Endocrinology 146(3):1138\u20131144","journal-title":"Endocrinology"},{"key":"96_CR96","doi-asserted-by":"crossref","unstructured":"Sun LY et al (2017) Longevity is impacted by growth hormone action during early postnatal period. Elife 6","DOI":"10.7554\/eLife.24059"},{"issue":"5","key":"96_CR97","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1210\/jc.2016-2046","volume":"102","author":"AJ Swerdlow","year":"2017","unstructured":"Swerdlow AJ et al (2017) Cancer risks in patients treated with growth hormone in childhood: the SAGhE European cohort study. J Clin Endocrinol Metab 102(5):1661\u20131672","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"96_CR98","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/acel.12583","volume":"16","author":"S Tarantini","year":"2017","unstructured":"Tarantini S et al (2017) Insulin-like growth factor 1 deficiency exacerbates hypertension-induced cerebral microhemorrhages in mice, mimicking the aging phenotype. Aging Cell 16(3):469\u2013479","journal-title":"Aging Cell"},{"issue":"10","key":"96_CR99","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1093\/gerona\/glp091","volume":"64","author":"MO Thorner","year":"2009","unstructured":"Thorner MO (2009) Statement by the growth hormone research society on the GH\/IGF-I axis in extending health span. J Gerontol A Biol Sci Med Sci 64(10):1039\u20131044","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"2","key":"96_CR100","doi-asserted-by":"crossref","first-page":"B106","DOI":"10.1093\/gerona\/55.2.B106","volume":"55","author":"PL Thornton","year":"2000","unstructured":"Thornton PL, Ingram RL, Sonntag WE (2000) Chronic [D-Ala2]-growth hormone-releasing hormone administration attenuates age-related deficits in spatial memory. J Gerontol A Biol Sci Med Sci 55(2):B106\u2013B112","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"6","key":"96_CR101","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1111\/acel.12372","volume":"14","author":"P Toth","year":"2015","unstructured":"Toth P et al (2015) IGF-1 deficiency impairs neurovascular coupling in mice: implications for cerebromicrovascular aging. Aging Cell 14(6):1034\u20131044","journal-title":"Aging Cell"},{"issue":"4","key":"96_CR102","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.psyneuen.2004.10.002","volume":"30","author":"PS van Dam","year":"2005","unstructured":"van Dam PS et al (2005) Childhood-onset growth hormone deficiency, cognitive function and brain N-acetylaspartate. Psychoneuroendocrinology 30(4):357\u2013363","journal-title":"Psychoneuroendocrinology"},{"issue":"2","key":"96_CR103","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1474-9728.2005.00148.x","volume":"4","author":"D van Heemst","year":"2005","unstructured":"van Heemst D et al (2005) Reduced insulin\/IGF-1 signalling and human longevity. Aging Cell 4(2):79\u201385","journal-title":"Aging Cell"},{"issue":"12","key":"96_CR104","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1093\/gerona\/59.12.1244","volume":"59","author":"M Vergara","year":"2004","unstructured":"Vergara M et al (2004) Hormone-treated Snell dwarf mice regain fertility but remain long lived and disease resistant. J Gerontol A Biol Sci Med Sci 59(12):1244\u20131250","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"2","key":"96_CR105","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.neurobiolaging.2005.01.010","volume":"27","author":"MV Vitiello","year":"2006","unstructured":"Vitiello MV et al (2006) Growth hormone releasing hormone improves the cognition of healthy older adults. Neurobiol Aging 27(2):318\u2013323","journal-title":"Neurobiol Aging"},{"issue":"5","key":"96_CR106","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1210\/jc.2004-1254","volume":"90","author":"MJ Walenkamp","year":"2005","unstructured":"Walenkamp MJ et al (2005) Homozygous and heterozygous expression of a novel insulin-like growth factor-I mutation. J Clin Endocrinol Metab 90(5):2855\u20132864","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"96_CR107","first-page":"153","volume":"80","author":"JU Weaver","year":"1995","unstructured":"Weaver JU et al (1995) The effect of low dose recombinant human growth hormone replacement on regional fat distribution, insulin sensitivity, and cardiovascular risk factors in hypopituitary adults. J Clin Endocrinol Metab 80(1):153\u2013159","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"96_CR108","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1093\/gerona\/gln075","volume":"64","author":"R Westbrook","year":"2009","unstructured":"Westbrook R et al (2009) Alterations in oxygen consumption, respiratory quotient, and heat production in long-lived GHRKO and Ames dwarf mice, and short-lived bGH transgenic mice. J Gerontol A Biol Sci Med Sci 64(4):443\u2013451","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"11","key":"96_CR109","doi-asserted-by":"crossref","first-page":"4413","DOI":"10.1210\/jc.2008-1239","volume":"93","author":"WM Widdowson","year":"2008","unstructured":"Widdowson WM, Gibney J (2008) The effect of growth hormone replacement on exercise capacity in patients with GH deficiency: a metaanalysis. J Clin Endocrinol Metab 93(11):4413\u20134417","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"96_CR110","volume":"9","author":"H Zhang","year":"2014","unstructured":"Zhang H et al (2014) The effect and mechanism of growth hormone replacement on cognitive function in rats with traumatic brain injury. PLoS One 9(9):e108518","journal-title":"PLoS One"},{"issue":"24","key":"96_CR111","doi-asserted-by":"crossref","first-page":"13215","DOI":"10.1073\/pnas.94.24.13215","volume":"94","author":"Y Zhou","year":"1997","unstructured":"Zhou Y et al (1997) A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor\/binding protein gene (the Laron mouse). Proc Natl Acad Sci U S A 94(24):13215\u201313220","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["GeroScience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11357-019-00096-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11357-019-00096-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11357-019-00096-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T23:22:27Z","timestamp":1599088947000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11357-019-00096-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,4]]},"references-count":111,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["96"],"URL":"https:\/\/doi.org\/10.1007\/s11357-019-00096-w","relation":{},"ISSN":["2509-2715","2509-2723"],"issn-type":[{"value":"2509-2715","type":"print"},{"value":"2509-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,4]]},"assertion":[{"value":"17 June 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 September 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}