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Besides its major role in the production of cerebrospinal fluid (CSF), it conveys signals originating from the brain, and from the circulatory system, shaping brain function in health and in pathology. Previous studies in rodents have revealed altered transcriptome both during aging and in various diseases of the central nervous system, including Alzheimer\u2019s disease. In the present study, a high-throughput sequencing of the CP transcriptome was performed in postmortem samples of clinically healthy individuals aged 50\u2019s through 80\u2019s. The data shows an age-related profile, with the main changes occurring in the transition from the 50\u2019s to the 60\u2019s, stabilizing thereafter. Specifically, neuronal and membrane functions distinguish the transcriptome between the 50\u2019s and the 60\u2019s, while neuronal and axon development and extracellular structure organization differentiate the 50\u2019s from the 70\u2019s. 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Future studies will unravel whether these relate with processes occurring in late- onset brain diseases.<\/jats:p>","DOI":"10.1007\/s11357-021-00329-x","type":"journal-article","created":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T12:04:20Z","timestamp":1613131460000},"page":"225-237","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Are the 50\u2019s, the transition decade, in choroid plexus aging?"],"prefix":"10.1007","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7036-7305","authenticated-orcid":false,"given":"Ana","family":"Tahira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3612-1870","authenticated-orcid":false,"given":"Fernanda","family":"Marques","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2687-5011","authenticated-orcid":false,"given":"Bianca","family":"Lisboa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1810-2203","authenticated-orcid":false,"given":"Arthur","family":"Feltrin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3261-984X","authenticated-orcid":false,"given":"Andr\u00e9","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2203-5573","authenticated-orcid":false,"given":"K\u00e1tia Cristina","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6315-7484","authenticated-orcid":false,"given":"Carlos Alberto","family":"de Bragan\u00e7a Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5878-398X","authenticated-orcid":false,"given":"Renata","family":"Leite","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6809-0618","authenticated-orcid":false,"given":"Lea","family":"Grinberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5942-4778","authenticated-orcid":false,"given":"Claudia","family":"Suemoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6159-5787","authenticated-orcid":false,"given":"Renata Eloah","family":"de Lucena Ferretti-Rebustini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6608-2473","authenticated-orcid":false,"given":"Carlos Augusto","family":"Pasqualucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2290-4492","authenticated-orcid":false,"given":"Wilson","family":"Jacob-Filho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5192-4682","authenticated-orcid":false,"given":"Helena","family":"Brentani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8866-368X","authenticated-orcid":false,"given":"Joana Almeida","family":"Palha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,2,12]]},"reference":[{"key":"329_CR1","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1159\/000440697","volume":"41","author":"L Perna","year":"2016","unstructured":"Perna L, Mons U, Rujescu D, Kliegel M, Brenner H. 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