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OH is currently diagnosed in a clinical setting with single-time point cuff measurements. Continuous blood pressure (BP) devices can measure OH dynamics but cannot be used for daily life monitoring. Near-infrared spectroscopy (NIRS) has potential diagnostic value in measuring cerebral oxygenation continuously over a longer time period, but this needs further validation. This study aimed to compare NIRS-measured (cerebral) oxygenation with continuous BP and transcranial Doppler-measured cerebral blood velocity (CBv) during postural changes. This cross-sectional study included 41 participants between 20 and 88 years old. BP, CBv, and cerebral (long channels) and superficial (short channels) oxygenated hemoglobin (O<jats:sub>2<\/jats:sub>Hb) were measured continuously during various postural changes. Pearson correlations between BP, CBv, and O<jats:sub>2<\/jats:sub>Hb were calculated over curves and specific characteristics (maximum drop amplitude and recovery). BP and O<jats:sub>2<\/jats:sub>Hb only showed good curve-based correlations (0.58\u20130.75) in the initial 30 s after standing up. Early (30\u201340 s) and 1-min BP recovery associated significantly with O<jats:sub>2<\/jats:sub>Hb, but no consistent associations were found for maximum drop amplitude and late (60\u2013175 s) recovery values. Associations between CBv and O<jats:sub>2<\/jats:sub>Hb were poor, but stronger for long-channel than short-channel measurements. BP associated well with NIRS-measured O<jats:sub>2<\/jats:sub>Hb in the first 30 s after postural change. Stronger associations for CBv with long-channel O<jats:sub>2<\/jats:sub>Hb suggest that long-channel NIRS specifically reflects cerebral blood flow during postural transitions, necessary to better understand the consequences of OH such as intolerance symptoms.<\/jats:p>","DOI":"10.1007\/s11357-023-00791-9","type":"journal-article","created":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T02:02:45Z","timestamp":1681264965000},"page":"2643-2657","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Capturing postural blood pressure dynamics with near-infrared spectroscopy-measured cerebral oxygenation"],"prefix":"10.1007","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2454-534X","authenticated-orcid":false,"given":"Marjolein","family":"Klop","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rianne A. 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