{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:42:41Z","timestamp":1788385361535,"version":"build-2803163510"},"reference-count":85,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2024,5,11]],"date-time":"2024-05-11T00:00:00Z","timestamp":1715385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,5,11]],"date-time":"2024-05-11T00:00:00Z","timestamp":1715385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100016200","name":"Medical College of Georgia, Augusta University","doi-asserted-by":"publisher","award":["MCGFD08343"],"award-info":[{"award-number":["MCGFD08343"]}],"id":[{"id":"10.13039\/100016200","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012127","name":"Augusta University","doi-asserted-by":"publisher","award":["RIA00056"],"award-info":[{"award-number":["RIA00056"]}],"id":[{"id":"10.13039\/100012127","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG062655"],"award-info":[{"award-number":["R01AG062655"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS114560"],"award-info":[{"award-number":["NS114560"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["GeroScience"],"DOI":"10.1007\/s11357-024-01183-3","type":"journal-article","created":{"date-parts":[[2024,5,11]],"date-time":"2024-05-11T04:01:56Z","timestamp":1715400116000},"page":"5439-5457","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Single episode of moderate to severe traumatic brain injury leads to chronic neurological deficits and Alzheimer\u2019s-like pathological dementia"],"prefix":"10.1007","volume":"46","author":[{"given":"Kumar","family":"Vaibhav","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayuri","family":"Gulhane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Ahluwalia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meenakshi","family":"Ahluwalia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashiq M.","family":"Rafiq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vibha","family":"Amble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela G.","family":"Zabala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob B.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liam","family":"Goldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashis K.","family":"Mondal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferenc","family":"Deak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravindra","family":"Kolhe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali S.","family":"Arbab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando L.","family":"Vale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,11]]},"reference":[{"key":"1183_CR1","doi-asserted-by":"crossref","unstructured":"Dewan MC, et al. Estimating the global incidence of traumatic brain injury. J Neurosurg. 2018;130(4):1080\u201397.","DOI":"10.3171\/2017.10.JNS17352"},{"issue":"12","key":"1183_CR2","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/S1474-4422(17)30371-X","volume":"16","author":"AIR Maas","year":"2017","unstructured":"Maas AIR, et al. Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research. Lancet Neurol. 2017;16(12):987\u20131048.","journal-title":"Lancet Neurol"},{"issue":"8","key":"1183_CR3","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1136\/jnnp.2010.222232","volume":"82","author":"TM McMillan","year":"2011","unstructured":"McMillan TM, et al. Death after head injury: the 13 year outcome of a case control study. J Neurol Neurosurg Psychiatry. 2011;82(8):931\u20135.","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"11","key":"1183_CR4","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1136\/jnnp-2017-317557","volume":"90","author":"SNG Neil","year":"2019","unstructured":"Neil SNG, David JS. Understanding neurodegeneration after traumatic brain injury: from mechanisms to clinical trials in dementia. J Neurol Neurosurg Psychiatry. 2019;90(11):1221.","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"11","key":"1183_CR5","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1089\/neu.2019.6510","volume":"37","author":"X Mao","year":"2019","unstructured":"Mao X, et al. Progressive histopathological damage occurring up to one year after experimental traumatic brain injury is associated with cognitive decline and depression-like behavior. J Neurotrauma. 2019;37(11):1331\u201341.","journal-title":"J Neurotrauma"},{"key":"1183_CR6","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.expneurol.2017.11.003","volume":"300","author":"F Pischiutta","year":"2018","unstructured":"Pischiutta F, et al. Single severe traumatic brain injury produces progressive pathology with ongoing contralateral white matter damage one year after injury. Exp Neurol. 2018;300:167\u201378.","journal-title":"Exp Neurol"},{"issue":"10","key":"1183_CR7","doi-asserted-by":"publisher","first-page":"389","DOI":"10.3390\/biomedicines8100389","volume":"8","author":"A Jarrahi","year":"2020","unstructured":"Jarrahi A, et al. Revisiting traumatic brain injury: from molecular mechanisms to therapeutic interventions. Biomedicines. 2020;8(10):389.","journal-title":"Biomedicines"},{"issue":"4","key":"1183_CR8","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1159\/000525111","volume":"56","author":"MA Sperl","year":"2022","unstructured":"Sperl MA, et al. Long-term risk of stroke after traumatic brain injury: a population-based medical record review study. Neuroepidemiology. 2022;56(4):283\u201390.","journal-title":"Neuroepidemiology"},{"key":"1183_CR9","doi-asserted-by":"publisher","first-page":"198","DOI":"10.3389\/fneur.2019.00198","volume":"10","author":"MG de Freitas Cardoso","year":"2019","unstructured":"de Freitas Cardoso MG, et al. Cognitive impairment following acute mild traumatic brain injury. Front Neurol. 2019;10:198.","journal-title":"Front Neurol"},{"issue":"2","key":"1183_CR10","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1007\/s00415-021-10669-5","volume":"269","author":"AZ Mohamed","year":"2022","unstructured":"Mohamed AZ, et al. Traumatic brain injury fast-forwards Alzheimer\u2019s pathology: evidence from amyloid positron emission tomorgraphy imaging. J Neurol. 2022;269(2):873\u201384.","journal-title":"J Neurol"},{"issue":"9","key":"1183_CR11","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/s11920-016-0719-9","volume":"18","author":"JS Young","year":"2016","unstructured":"Young JS, Hobbs JG, Bailes JE. The impact of traumatic brain injury on the aging brain. Curr Psychiatry Rep. 2016;18(9):81.","journal-title":"Curr Psychiatry Rep"},{"issue":"4","key":"1183_CR12","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1037\/neu0000431","volume":"32","author":"C LoBue","year":"2018","unstructured":"LoBue C, et al. Traumatic brain injury history and progression from mild cognitive impairment to Alzheimer disease. Neuropsychology. 2018;32(4):401\u20139.","journal-title":"Neuropsychology"},{"issue":"10","key":"1183_CR13","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/S1474-4422(17)30279-X","volume":"16","author":"L Wilson","year":"2017","unstructured":"Wilson L, et al. The chronic and evolving neurological consequences of traumatic brain injury. Lancet Neurol. 2017;16(10):813\u201325.","journal-title":"Lancet Neurol"},{"issue":"8","key":"1183_CR14","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1089\/neu.2010.1358","volume":"27","author":"BE Masel","year":"2010","unstructured":"Masel BE, DeWitt DS. Traumatic brain injury: a disease process, not an event. J Neurotrauma. 2010;27(8):1529\u201340.","journal-title":"J Neurotrauma"},{"issue":"2","key":"1183_CR15","doi-asserted-by":"publisher","first-page":"511","DOI":"10.3171\/2015.2.JNS14503","volume":"124","author":"DC Perry","year":"2016","unstructured":"Perry DC, et al. Association of traumatic brain injury with subsequent neurological and psychiatric disease: a meta-analysis. J Neurosurg. 2016;124(2):511\u201326.","journal-title":"J Neurosurg"},{"issue":"3","key":"1183_CR16","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1176\/appi.ajp.2009.09050617","volume":"167","author":"RA Bryant","year":"2010","unstructured":"Bryant RA, et al. The psychiatric sequelae of traumatic injury. Am J Psychiatry. 2010;167(3):312\u201320.","journal-title":"Am J Psychiatry"},{"issue":"9","key":"1183_CR17","first-page":"1509","volume":"23","author":"JD MacKenzie","year":"2002","unstructured":"MacKenzie JD, et al. Brain atrophy in mild or moderate traumatic brain injury: a longitudinal quantitative analysis. Am J Neuroradiol. 2002;23(9):1509\u201315.","journal-title":"Am J Neuroradiol"},{"issue":"1","key":"1183_CR18","doi-asserted-by":"publisher","first-page":"147","DOI":"10.2214\/ajr.160.1.8416613","volume":"160","author":"I Reider-Groswasser","year":"1993","unstructured":"Reider-Groswasser I, et al. Late CT findings in brain trauma: relationship to cognitive and behavioral sequelae and to vocational outcome. AJR Am J Roentgenol. 1993;160(1):147\u201352.","journal-title":"AJR Am J Roentgenol"},{"issue":"1","key":"1183_CR19","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1097\/NEN.0000000000000021","volume":"73","author":"DJ Loane","year":"2014","unstructured":"Loane DJ, et al. Progressive neurodegeneration after experimental brain trauma: association with chronic microglial activation. J Neuropathol Exp Neurol. 2014;73(1):14\u201329.","journal-title":"J Neuropathol Exp Neurol"},{"issue":"1","key":"1183_CR20","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/s13311-014-0319-5","volume":"12","author":"AI Faden","year":"2015","unstructured":"Faden AI, Loane DJ. Chronic neurodegeneration after traumatic brain injury: Alzheimer disease, chronic traumatic encephalopathy, or persistent neuroinflammation? Neurotherapeutics. 2015;12(1):143\u201350.","journal-title":"Neurotherapeutics"},{"issue":"13","key":"1183_CR21","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1089\/neu.2017.5399","volume":"35","author":"RM Ritzel","year":"2018","unstructured":"Ritzel RM, et al. Chronic alterations in systemic immune function after traumatic brain injury. J Neurotrauma. 2018;35(13):1419\u201336.","journal-title":"J Neurotrauma"},{"issue":"1","key":"1183_CR22","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1093\/brain\/aws322","volume":"136","author":"VE Johnson","year":"2013","unstructured":"Johnson VE, et al. Inflammation and white matter degeneration persist for years after a single traumatic brain injury. Brain. 2013;136(1):28\u201342.","journal-title":"Brain"},{"issue":"3","key":"1183_CR23","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1002\/ana.22455","volume":"70","author":"AF Ramlackhansingh","year":"2011","unstructured":"Ramlackhansingh AF, et al. Inflammation after trauma: microglial activation and traumatic brain injury. Ann Neurol. 2011;70(3):374\u201383.","journal-title":"Ann Neurol"},{"issue":"5","key":"1183_CR24","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1007\/s11357-020-00245-6","volume":"42","author":"A Irimia","year":"2020","unstructured":"Irimia A, et al. Acute cognitive deficits after traumatic brain injury predict Alzheimer\u2019s disease-like degradation of the human default mode network. Geroscience. 2020;42(5):1411\u201329.","journal-title":"Geroscience"},{"key":"1183_CR25","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1146\/annurev-pathol-012615-044116","volume":"11","author":"J Hay","year":"2016","unstructured":"Hay J, et al. Chronic traumatic encephalopathy: the neuropathological legacy of traumatic brain injury. Annu Rev Pathol. 2016;11:21\u201345.","journal-title":"Annu Rev Pathol"},{"issue":"3","key":"1183_CR26","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1002\/jcp.25629","volume":"232","author":"SA Acosta","year":"2017","unstructured":"Acosta SA, et al. Increased amyloid precursor protein and tau expression manifests as key secondary cell death in chronic traumatic brain injury. J Cell Physiol. 2017;232(3):665\u201377.","journal-title":"J Cell Physiol"},{"issue":"11","key":"1183_CR27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078851","volume":"8","author":"N Tajiri","year":"2013","unstructured":"Tajiri N, et al. Traumatic brain injury precipitates cognitive impairment and extracellular A\u03b2 aggregation in Alzheimer\u2019s disease transgenic mice. PLoS ONE. 2013;8(11): e78851.","journal-title":"PLoS ONE"},{"issue":"1","key":"1183_CR28","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1002\/alz.12671","volume":"19","author":"L Zhang","year":"2023","unstructured":"Zhang L, et al. Association of life-course traumatic brain injury with dementia risk: a nationwide twin study. Alzheimer\u2019s Dement. 2023;19(1):217\u201325.","journal-title":"Alzheimer\u2019s Dement"},{"issue":"5","key":"1183_CR29","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/S2215-0366(18)30065-8","volume":"5","author":"JR Fann","year":"2018","unstructured":"Fann JR, et al. Long-term risk of dementia among people with traumatic brain injury in Denmark: a population-based observational cohort study. Lancet Psychiatry. 2018;5(5):424\u201331.","journal-title":"Lancet Psychiatry"},{"issue":"9","key":"1183_CR30","doi-asserted-by":"publisher","first-page":"3615","DOI":"10.4049\/jimmunol.1601948","volume":"198","author":"M Braun","year":"2017","unstructured":"Braun M, et al. Activation of myeloid TLR4 mediates T lymphocyte polarization after traumatic brain injury. J Immunol. 2017;198(9):3615\u201326.","journal-title":"J Immunol"},{"key":"1183_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2023.114320","volume":"361","author":"M Ahluwalia","year":"2023","unstructured":"Ahluwalia M, et al. Altered endocannabinoid metabolism compromises the brain-CSF barrier and exacerbates chronic deficits after traumatic brain injury in mice. Exp Neurol. 2023;361: 114320.","journal-title":"Exp Neurol"},{"issue":"22","key":"1183_CR32","doi-asserted-by":"publisher","first-page":"eaax8847","DOI":"10.1126\/sciadv.aax8847","volume":"6","author":"K Vaibhav","year":"2020","unstructured":"Vaibhav K, et al. Neutrophil extracellular traps exacerbate neurological deficits after traumatic brain injury. Sci Adv. 2020;6(22):eaax8847.","journal-title":"Sci Adv"},{"key":"1183_CR33","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3389\/fneur.2014.00209","volume":"5","author":"I Cernak","year":"2014","unstructured":"Cernak I, et al. A novel mouse model of penetrating brain injury. Front Neurol. 2014;5:209.","journal-title":"Front Neurol"},{"key":"1183_CR34","doi-asserted-by":"crossref","unstructured":"Luong TN, et al. Assessment of motor balance and coordination in mice using the balance beam. J Vis Exp. 2011;(49):e2379.","DOI":"10.3791\/2376"},{"key":"1183_CR35","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.bbi.2016.09.001","volume":"61","author":"KS Evonuk","year":"2017","unstructured":"Evonuk KS, et al. Myocardial ischemia\/reperfusion impairs neurogenesis and hippocampal-dependent learning and memory. Brain Behav Immun. 2017;61:266\u201373.","journal-title":"Brain Behav Immun"},{"key":"1183_CR36","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.ejphar.2014.09.015","volume":"747","author":"R Tabassum","year":"2015","unstructured":"Tabassum R, et al. Perillyl alcohol improves functional and histological outcomes against ischemia\u2013reperfusion injury by attenuation of oxidative stress and repression of COX-2, NOS-2 and NF-\u03baB in middle cerebral artery occlusion rats. Eur J Pharmacol. 2015;747:190\u20139.","journal-title":"Eur J Pharmacol"},{"issue":"6","key":"1183_CR37","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.3171\/2010.3.JNS091212","volume":"113","author":"C Wakade","year":"2010","unstructured":"Wakade C, et al. Delayed reduction in hippocampal postsynaptic density protein-95 expression temporally correlates with cognitive dysfunction following controlled cortical impact in mice. J Neurosurg. 2010;113(6):1195\u2013201.","journal-title":"J Neurosurg"},{"issue":"2","key":"1183_CR38","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.expneurol.2006.09.006","volume":"203","author":"V Bou\u00ebt","year":"2007","unstructured":"Bou\u00ebt V, et al. Sensorimotor and cognitive deficits after transient middle cerebral artery occlusion in the mouse. Exp Neurol. 2007;203(2):555\u201367.","journal-title":"Exp Neurol"},{"issue":"7","key":"1183_CR39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041229","volume":"7","author":"DE Kimbler","year":"2012","unstructured":"Kimbler DE, et al. Activation of P2X7 promotes cerebral edema and neurological injury after traumatic brain injury in mice. PLoS ONE. 2012;7(7): e41229.","journal-title":"PLoS ONE"},{"issue":"1","key":"1183_CR40","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1002\/glia.22581","volume":"62","author":"MD Laird","year":"2014","unstructured":"Laird MD, et al. High mobility group box protein-1 promotes cerebral edema after traumatic brain injury via activation of toll-like receptor 4. Glia. 2014;62(1):26\u201338.","journal-title":"Glia"},{"issue":"6","key":"1183_CR41","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1002\/cam4.4568","volume":"11","author":"P Ahluwalia","year":"2022","unstructured":"Ahluwalia P, et al. Clinical and molecular assessment of an onco-immune signature with prognostic significance in patients with colorectal cancer. Cancer Med. 2022;11(6):1573\u201386.","journal-title":"Cancer Med"},{"issue":"11","key":"1183_CR42","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.3390\/healthcare9111592","volume":"9","author":"R Kolhe","year":"2021","unstructured":"Kolhe R, et al. Nanostring-based identification of the gene expression profile in trigger finger samples. Healthcare (Basel). 2021;9(11):1592.","journal-title":"Healthcare (Basel)"},{"issue":"W1","key":"1183_CR43","doi-asserted-by":"publisher","first-page":"W191","DOI":"10.1093\/nar\/gkz369","volume":"47","author":"U Raudvere","year":"2019","unstructured":"Raudvere U, et al. g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update). Nucleic Acids Res. 2019;47(W1):W191-w198.","journal-title":"Nucleic Acids Res"},{"issue":"1\u20132","key":"1183_CR44","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/s11010-012-1321-z","volume":"367","author":"K Vaibhav","year":"2012","unstructured":"Vaibhav K, et al. Piperine suppresses cerebral ischemia-reperfusion-induced inflammation through the repression of COX-2, NOS-2, and NF-kappaB in middle cerebral artery occlusion rat model. Mol Cell Biochem. 2012;367(1\u20132):73\u201384.","journal-title":"Mol Cell Biochem"},{"issue":"1","key":"1183_CR45","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s12975-014-0374-6","volume":"6","author":"MB Khan","year":"2015","unstructured":"Khan MB, et al. Remote ischemic postconditioning: harnessing endogenous protection in a murine model of vascular cognitive impairment. Transl Stroke Res. 2015;6(1):69\u201377.","journal-title":"Transl Stroke Res"},{"issue":"3","key":"1183_CR46","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1002\/jmri.22837","volume":"35","author":"JW Totenhagen","year":"2012","unstructured":"Totenhagen JW, et al. In vivo assessment of neurodegeneration in Niemann-Pick type C mice by quantitative T2 mapping and diffusion tensor imaging. J Magn Reson Imaging. 2012;35(3):528\u201336.","journal-title":"J Magn Reson Imaging"},{"key":"1183_CR47","doi-asserted-by":"crossref","unstructured":"Ng SY, Lee AYW. Traumatic brain injuries: pathophysiology and potential therapeutic targets. Front Cell Neurosci. 2019;(13):528.","DOI":"10.3389\/fncel.2019.00528"},{"key":"1183_CR48","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/B978-0-444-52892-6.00004-0","volume":"127","author":"AC McKee","year":"2015","unstructured":"McKee AC, Daneshvar DH. The neuropathology of traumatic brain injury. Handb Clin Neurol. 2015;127:45\u201366.","journal-title":"Handb Clin Neurol"},{"issue":"3","key":"1183_CR49","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.3233\/JAD-220159","volume":"88","author":"MM Mielke","year":"2022","unstructured":"Mielke MM, et al. Traumatic brain injury and risk of Alzheimer\u2019s disease and related dementias in the population. J Alzheimers Dis. 2022;88(3):1049\u201359.","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"1183_CR50","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002496","volume":"15","author":"A Nordstr\u00f6m","year":"2018","unstructured":"Nordstr\u00f6m A, Nordstr\u00f6m P. Traumatic brain injury and the risk of dementia diagnosis: a nationwide cohort study. PLoS Med. 2018;15(1): e1002496.","journal-title":"PLoS Med"},{"issue":"8","key":"1183_CR51","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002103","volume":"13","author":"A Sariaslan","year":"2016","unstructured":"Sariaslan A, et al. Long-term outcomes associated with traumatic brain injury in childhood and adolescence: a nationwide Swedish cohort study of a wide range of medical and social outcomes. PLoS Med. 2016;13(8): e1002103.","journal-title":"PLoS Med"},{"key":"1183_CR52","unstructured":"Gugger JJ, et al. Change in structural brain network abnormalities after traumatic brain injury determines post-injury recovery. arXiv preprint arXiv:2205.14663, 2022."},{"issue":"6","key":"1183_CR53","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1179\/016164103101201977","volume":"25","author":"G Aliev","year":"2003","unstructured":"Aliev G, et al. Mitochondria and vascular lesions as a central target for the development of Alzheimer\u2019s disease and Alzheimer disease-like pathology in transgenic mice. Neurol Res. 2003;25(6):665\u201374.","journal-title":"Neurol Res"},{"key":"1183_CR54","first-page":"1","volume":"2011","author":"N Jantaratnotai","year":"2011","unstructured":"Jantaratnotai N, et al. Comparison of vascular perturbations in an A\u03b2-injected animal model and in AD brain. Int J Alzheimer\u2019s Dis. 2011;2011:1\u20138.","journal-title":"Int J Alzheimer\u2019s Dis"},{"key":"1183_CR55","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/S0022-510X(02)00289-7","volume":"203","author":"B Borroni","year":"2002","unstructured":"Borroni B, et al. Microvascular damage and platelet abnormalities in early Alzheimer\u2019s disease. J Neurol Sci. 2002;203:189\u201393.","journal-title":"J Neurol Sci"},{"issue":"3","key":"1183_CR56","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.mvr.2007.10.004","volume":"75","author":"DG Walker","year":"2008","unstructured":"Walker DG, Dalsing-Hernandez JE, Lue L-F. Human postmortem brain-derived cerebrovascular smooth muscle cells express all genes of the classical complement pathway: a potential mechanism for vascular damage in cerebral amyloid angiopathy and Alzheimer\u2019s disease. Microvasc Res. 2008;75(3):411\u20139.","journal-title":"Microvasc Res"},{"issue":"2","key":"1183_CR57","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.archger.2011.09.016","volume":"55","author":"Y Yesil","year":"2012","unstructured":"Yesil Y, et al. Increased mean platelet volume (MPV) indicating the vascular risk in Alzheimer\u2019s disease (AD). Arch Gerontol Geriatr. 2012;55(2):257\u201360.","journal-title":"Arch Gerontol Geriatr"},{"issue":"1","key":"1183_CR58","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1093\/brain\/awaa372","volume":"144","author":"AE Jolly","year":"2021","unstructured":"Jolly AE, et al. Detecting axonal injury in individual patients after traumatic brain injury. Brain. 2021;144(1):92\u2013113.","journal-title":"Brain"},{"issue":"12","key":"1183_CR59","doi-asserted-by":"publisher","first-page":"3685","DOI":"10.1093\/brain\/awaa316","volume":"143","author":"NS Graham","year":"2020","unstructured":"Graham NS, et al. Diffuse axonal injury predicts neurodegeneration after moderate\u2013severe traumatic brain injury. Brain. 2020;143(12):3685\u201398.","journal-title":"Brain"},{"key":"1183_CR60","doi-asserted-by":"crossref","unstructured":"Jerstad T, et al. Predicting functional outcome one year after traumatic brain injury with CT and MRI findings. 2012;2(4):134\u201344.","DOI":"10.4021\/jnr133w"},{"issue":"11","key":"1183_CR61","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1136\/jnnp-2017-317557","volume":"90","author":"NS Graham","year":"2019","unstructured":"Graham NS, Sharp DJ. Understanding neurodegeneration after traumatic brain injury: from mechanisms to clinical trials in dementia. J Neurol Neurosurg Psychiatry. 2019;90(11):1221\u201333.","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"4","key":"1183_CR62","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/nrneurol.2013.29","volume":"9","author":"DH Smith","year":"2013","unstructured":"Smith DH, Johnson VE, Stewart W. Chronic neuropathologies of single and repetitive TBI: substrates of dementia? Nat Rev Neurol. 2013;9(4):211\u201321.","journal-title":"Nat Rev Neurol"},{"issue":"613","key":"1183_CR63","doi-asserted-by":"publisher","first-page":"eabg9922","DOI":"10.1126\/scitranslmed.abg9922","volume":"13","author":"NS Graham","year":"2021","unstructured":"Graham NS, et al. Axonal marker neurofilament light predicts long-term outcomes and progressive neurodegeneration after traumatic brain injury. Sci Transl Med. 2021;13(613):eabg9922.","journal-title":"Sci Transl Med"},{"issue":"6","key":"1183_CR64","doi-asserted-by":"publisher","first-page":"e623","DOI":"10.1212\/WNL.0000000000009985","volume":"95","author":"P Shahim","year":"2020","unstructured":"Shahim P, et al. Time course and diagnostic utility of NfL, tau, GFAP, and UCH-L1 in subacute and chronic TBI. Neurology. 2020;95(6):e623\u201336.","journal-title":"Neurology"},{"key":"1183_CR65","doi-asserted-by":"crossref","unstructured":"Newcombe VFJ, et al. Post-acute blood biomarkers and disease progression in traumatic brain injury. Brain. 2022;145(6):2064\u201376.","DOI":"10.1093\/brain\/awac126"},{"issue":"1\u20133","key":"1183_CR66","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1159\/000283480","volume":"7","author":"P Eikelenboom","year":"2010","unstructured":"Eikelenboom P, et al. Neuroinflammation\u2013an early event in both the history and pathogenesis of Alzheimer\u2019s disease. Neurodegener Dis. 2010;7(1\u20133):38\u201341.","journal-title":"Neurodegener Dis"},{"issue":"4","key":"1183_CR67","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/nrneurol.2010.17","volume":"6","author":"VH Perry","year":"2010","unstructured":"Perry VH, Nicoll JA, Holmes C. Microglia in neurodegenerative disease. Nat Rev Neurol. 2010;6(4):193\u2013201.","journal-title":"Nat Rev Neurol"},{"issue":"2\u20133","key":"1183_CR68","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.forsciint.2004.06.027","volume":"146","author":"S Gentleman","year":"2004","unstructured":"Gentleman S, et al. Long-term intracerebral inflammatory response after traumatic brain injury. Forensic Sci Int. 2004;146(2\u20133):97\u2013104.","journal-title":"Forensic Sci Int"},{"issue":"9","key":"1183_CR69","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1002\/glia.23171","volume":"65","author":"S Villapol","year":"2017","unstructured":"Villapol S, Loane DJ, Burns MP. Sexual dimorphism in the inflammatory response to traumatic brain injury. Glia. 2017;65(9):1423\u201338.","journal-title":"Glia"},{"issue":"1","key":"1183_CR70","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-019-48145-w","volume":"9","author":"F Trautz","year":"2019","unstructured":"Trautz F, et al. Survival-time dependent increase in neuronal IL-6 and astroglial GFAP expression in fatally injured human brain tissue. Sci Rep. 2019;9(1):1\u201315.","journal-title":"Sci Rep"},{"issue":"1","key":"1183_CR71","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1186\/s12974-021-02197-w","volume":"18","author":"BP Todd","year":"2021","unstructured":"Todd BP, et al. Traumatic brain injury results in unique microglial and astrocyte transcriptomes enriched for type I interferon response. J Neuroinflammation. 2021;18(1):151.","journal-title":"J Neuroinflammation"},{"issue":"1","key":"1183_CR72","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1176\/appi.neuropsych.17070145","volume":"30","author":"C LoBue","year":"2017","unstructured":"LoBue C, et al. Neurodegenerative dementias after traumatic brain injury. J Neuropsychiatry Clin Neurosci. 2017;30(1):7\u201313.","journal-title":"J Neuropsychiatry Clin Neurosci"},{"issue":"3","key":"1183_CR73","doi-asserted-by":"publisher","first-page":"153","DOI":"10.3109\/13506120009146830","volume":"7","author":"TA Davies","year":"2000","unstructured":"Davies TA, et al. \u03b2 amyloid fragments derived from activated platelets deposit in cerebrovascular endothelium: usage of a novel blood brain barrier endothelial cell model system. Amyloid. 2000;7(3):153\u201365.","journal-title":"Amyloid"},{"issue":"3","key":"1183_CR74","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.neulet.2009.09.043","volume":"466","author":"R Mlekusch","year":"2009","unstructured":"Mlekusch R, Humpel C. Matrix metalloproteinases-2 and-3 are reduced in cerebrospinal fluid with low beta-amyloid1\u201342 levels. Neurosci Lett. 2009;466(3):135\u20138.","journal-title":"Neurosci Lett"},{"issue":"6","key":"1183_CR75","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1111\/j.1365-2990.2010.01084.x","volume":"36","author":"JC Palmer","year":"2010","unstructured":"Palmer JC, Kehoe PG, Love S. Endothelin-converting enzyme-1 in Alzheimer\u2019s disease and vascular dementia. Neuropathol Appl Neurobiol. 2010;36(6):487\u201397.","journal-title":"Neuropathol Appl Neurobiol"},{"key":"1183_CR76","doi-asserted-by":"publisher","first-page":"238","DOI":"10.3389\/fnagi.2014.00238","volume":"6","author":"JS Miners","year":"2014","unstructured":"Miners JS, et al. A\u03b2 degradation or cerebral perfusion? Divergent effects of multifunctional enzymes. Front Aging Neurosci. 2014;6:238.","journal-title":"Front Aging Neurosci"},{"issue":"9","key":"1183_CR77","doi-asserted-by":"publisher","first-page":"1554","DOI":"10.1002\/alz.12321","volume":"17","author":"CM Moloney","year":"2021","unstructured":"Moloney CM, Lowe VJ, Murray ME. Visualization of neurofibrillary tangle maturity in Alzheimer\u2019s disease: a clinicopathologic perspective for biomarker research. Alzheimer\u2019s Dement. 2021;17(9):1554\u201374.","journal-title":"Alzheimer\u2019s Dement"},{"key":"1183_CR78","doi-asserted-by":"crossref","unstructured":"Carron SF, Alwis DS, Rajan R. Traumatic brain injury and neuronal functionality changes in sensory cortex. Front Syst Neurosci. 2016;(10):47.","DOI":"10.3389\/fnsys.2016.00047"},{"issue":"1","key":"1183_CR79","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1017\/S1355617718000851","volume":"25","author":"LD Crocker","year":"2019","unstructured":"Crocker LD, et al. Mild traumatic brain injury burden moderates the relationship between cognitive functioning and suicidality in Iraq\/Afghanistan-Era veterans. J Int Neuropsychol Soc. 2019;25(1):79\u201389.","journal-title":"J Int Neuropsychol Soc"},{"key":"1183_CR80","doi-asserted-by":"publisher","first-page":"157","DOI":"10.3389\/fneur.2013.00157","volume":"4","author":"O Malkesman","year":"2013","unstructured":"Malkesman O, et al. Traumatic brain injury - modeling neuropsychiatric symptoms in rodents. Front Neurol. 2013;4:157\u2013157.","journal-title":"Front Neurol"},{"issue":"7","key":"1183_CR81","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1136\/jnnp.74.7.857","volume":"74","author":"S Fleminger","year":"2003","unstructured":"Fleminger S, et al. Head injury as a risk factor for Alzheimer\u2019s disease: the evidence 10 years on; a partial replication. J Neurol Neurosurg Psychiatry. 2003;74(7):857\u201362.","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"3","key":"1183_CR82","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1192\/bjp.bp.111.096461","volume":"201","author":"JJ Vasterling","year":"2012","unstructured":"Vasterling JJ, et al. Neuropsychological outcomes of mild traumatic brain injury, post-traumatic stress disorder and depression in Iraq-deployed US Army soldiers. Br J Psychiatry. 2012;201(3):186\u201392.","journal-title":"Br J Psychiatry"},{"issue":"7","key":"1183_CR83","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1038\/jcbfm.2014.75","volume":"34","author":"SL Aungst","year":"2014","unstructured":"Aungst SL, et al. Repeated mild traumatic brain injury causes chronic neuroinflammation, changes in hippocampal synaptic plasticity, and associated cognitive deficits. J Cereb Blood Flow Metab. 2014;34(7):1223\u201332.","journal-title":"J Cereb Blood Flow Metab"},{"issue":"3","key":"1183_CR84","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/nrneurol.2014.15","volume":"10","author":"DJ Sharp","year":"2014","unstructured":"Sharp DJ, Scott G, Leech R. Network dysfunction after traumatic brain injury. Nat Rev Neurol. 2014;10(3):156\u201366.","journal-title":"Nat Rev Neurol"},{"issue":"1","key":"1183_CR85","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169650","volume":"12","author":"Y Li","year":"2017","unstructured":"Li Y, et al. Head injury as a risk factor for dementia and Alzheimer\u2019s disease: a systematic review and meta-analysis of 32 observational studies. PLoS ONE. 2017;12(1): e0169650.","journal-title":"PLoS ONE"}],"container-title":["GeroScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11357-024-01183-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11357-024-01183-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11357-024-01183-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T14:09:07Z","timestamp":1729606147000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11357-024-01183-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,11]]},"references-count":85,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1183"],"URL":"https:\/\/doi.org\/10.1007\/s11357-024-01183-3","relation":{},"ISSN":["2509-2723"],"issn-type":[{"value":"2509-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,11]]},"assertion":[{"value":"31 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that there is no financial conflict of interest. We also declare that one of the co-authors (FD) is an Associate Editor of Geroscience.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}