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Diagnostic intermittent blood pressure (BP) measurements are only a proxy for cerebral perfusion and do not reflect daily-life BP fluctuations. Near-infrared spectroscopy (NIRS)-measured cerebral oxygenation potentially overcomes these drawbacks. This study aimed to determine feasibility, face validity, and reliability of NIRS in the home environment. Ten participants with OH (2 female, mean age 77, <jats:italic>SD<\/jats:italic> 3.7) and 11 without OH (5 female, mean age 78, <jats:italic>SD<\/jats:italic> 6.7) wore a NIRS sensor at home on two different days for 10\u201311\u00a0h per day. Preceded by a laboratory-situated test, cerebral oxygenation was measured during three standardized supine-stand tests per day and during unsupervised daily life activities. Data availability, quality, and user experience were assessed (feasibility), as well as differences in posture-related oxygenation responses between participants with and without OH and between symptomatic (dizziness, light-headedness, blurred vision) and asymptomatic postural changes (face validity). Reliability was assessed through repetitive supine-stand tests. Up to 80% of the standardized home-based supine-stand tests could be analyzed. Oxygenation recovery values were lower for participants with OH (<jats:italic>p<\/jats:italic>\u2009=\u20090 .03\u20130.15); in those with OH, oxygenation showed a deeper maximum drop for symptomatic than asymptomatic postural changes (<jats:italic>p<\/jats:italic>\u2009=\u20090.04). Intra-class correlation coefficients varied from 0.07 to 0.40, with no consistent differences over measurements. This proof-of-concept study shows feasibility and face validity of at-home oxygenation monitoring using NIRS, confirming its potential value for diagnosis and monitoring in OH and OH-related symptoms. Further data are needed for conclusions about reliability.<\/jats:p>","DOI":"10.1007\/s11357-024-01241-w","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T18:12:44Z","timestamp":1718734364000},"page":"6331-6346","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Home-based monitoring of cerebral oxygenation in response to postural changes using near-infrared spectroscopy"],"prefix":"10.1007","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2454-534X","authenticated-orcid":false,"given":"Marjolein","family":"Klop","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurgen A. H. 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J NeuroEng Rehab. 2020;17(1):70. https:\/\/doi.org\/10.1186\/s12984-020-00692-4.","journal-title":"J NeuroEng Rehab"}],"container-title":["GeroScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11357-024-01241-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11357-024-01241-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11357-024-01241-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T15:12:49Z","timestamp":1729609969000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11357-024-01241-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,18]]},"references-count":48,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1241"],"URL":"https:\/\/doi.org\/10.1007\/s11357-024-01241-w","relation":{},"ISSN":["2509-2723"],"issn-type":[{"value":"2509-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,18]]},"assertion":[{"value":"7 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 June 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All participants gave written informed consent, and the study was performed in accordance with the Declaration of Helsinki. The study was judged to fall beyond the remits of the Dutch Medical Research Involving Human Subjects Act (WMO) from the local ethics committee (CMO Arnhem-Nijmegen), who therefore waived the need for central approval.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Marianne Floor-Westerdijk is an employee of Artinis Medical Systems and was involved in the development of the NIRS device used in this study. This research was part of a funded project in which Artinis Medical Systems (the manufacturer of the NIRS system) also participated. The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}