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This study investigates the relationship between PUD, <jats:italic>H. pylori<\/jats:italic> eradication, and dementia risk, including Alzheimer\u2019s disease (AD), in an elderly South Korean cohort, considering age and eradication timing. Data from the Korean National Health Insurance Service (2002\u20132015) for individuals aged 55\u201379 were analyzed. Participants were divided based on PUD and <jats:italic>H. pylori<\/jats:italic> therapy status. Propensity score matching was used to evaluate dementia incidence and hazard ratios over 5 and 10 years, alongside the timing of eradication therapy. PUD is linked to higher dementia risk at 5 and 10 years, more for overall dementia than AD, with eradication status not significantly altering the risk. Age-specific analysis showed increased AD risk in the 60s and 70s age groups. Late eradication therapy is correlated with a higher dementia risk. PUD is a risk factor for dementia in elderly South Koreans, particularly with delayed <jats:italic>H. pylori<\/jats:italic> therapy. The findings emphasize timely <jats:italic>H. pylori<\/jats:italic> management and its potential role in neurodegenerative disease prevention.<\/jats:p>","DOI":"10.1007\/s11357-024-01284-z","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T02:02:22Z","timestamp":1723428142000},"page":"1161-1174","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Impact of Helicobacter pylori eradication on age-specific risk of incident dementia in patients with peptic ulcer disease: a nationwide population-based cohort study"],"prefix":"10.1007","volume":"47","author":[{"given":"Dong Woo","family":"Kang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung-Won","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Man Young","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Hwan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoo Hyun","family":"Um","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng-Min","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang Uk","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Kook","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,8,12]]},"reference":[{"issue":"6","key":"1284_CR1","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.14336\/AD.2022.0412","volume":"13","author":"T Wu","year":"2022","unstructured":"Wu T, Lin D, Cheng Y, Jiang S, Riaz MW, Fu N, et al. 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