{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T04:21:46Z","timestamp":1744258906609,"version":"3.40.4"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG066515"],"award-info":[{"award-number":["AG066515"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["GeroScience"],"DOI":"10.1007\/s11357-024-01291-0","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T01:01:36Z","timestamp":1722387696000},"page":"1501-1515","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Age-associated proteins explain the role of medial temporal lobe networks in Alzheimer\u2019s disease"],"prefix":"10.1007","volume":"47","author":[{"given":"Adam","family":"Turnbull","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yejin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqian","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zihuai","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor W.","family":"Henderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. Vankee","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,7,31]]},"reference":[{"key":"1291_CR1","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1093\/brain\/awaa068","volume":"143","author":"D Berron","year":"2020","unstructured":"Berron D, van Westen D, Ossenkoppele R, Strandberg O, Hansson O. Medial temporal lobe connectivity and its associations with cognition in early Alzheimer\u2019s disease. Brain. 2020;143:1233\u201348.","journal-title":"Brain"},{"key":"1291_CR2","doi-asserted-by":"publisher","first-page":"e62114","DOI":"10.7554\/eLife.62114","volume":"9","author":"Q Chen","year":"2020","unstructured":"Chen Q, Turnbull A, Baran TM, Lin FV. Longitudinal stability of medial temporal lobe connectivity is associated with tau-related memory decline. eLife. 2020;9:e62114.","journal-title":"eLife"},{"key":"1291_CR3","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1002\/ana.24711","volume":"80","author":"H Cho","year":"2016","unstructured":"Cho H, Choi JY, Hwang MS, Kim YJ, Lee HM, Lee HS, Lee JH, Ryu YH, Lee MS, Lyoo CH. In vivo cortical spreading pattern of tau and amyloid in the Alzheimer disease spectrum. Ann Neurol. 2016;80:247\u201358.","journal-title":"Ann Neurol"},{"issue":"Suppl 1","key":"1291_CR4","doi-asserted-by":"publisher","first-page":"S141","DOI":"10.1016\/j.neurobiolaging.2014.03.041","volume":"36","author":"SR Das","year":"2015","unstructured":"Das SR, Pluta J, Mancuso L, Kliot D, Yushkevich PA, Wolk DA. Anterior and posterior MTL networks in aging and MCI. Neurobiol Aging. 2015;36(Suppl 1):S141\u201350.","journal-title":"Neurobiol Aging"},{"key":"1291_CR5","doi-asserted-by":"publisher","first-page":"3747","DOI":"10.1093\/brain\/awv283","volume":"138","author":"CR Jack Jr","year":"2015","unstructured":"Jack CR Jr, Wiste HJ, Weigand SD, Knopman DS, Mielke MM, Vemuri P, Lowe V, Senjem ML, Gunter JL, Reyes D. Different definitions of neurodegeneration produce similar amyloid\/neurodegeneration biomarker group findings. Brain. 2015;138:3747\u201359.","journal-title":"Brain"},{"key":"1291_CR6","doi-asserted-by":"publisher","first-page":"e13325","DOI":"10.1111\/acel.13325","volume":"20","author":"R Moaddel","year":"2021","unstructured":"Moaddel R, Ubaida-Mohien C, Tanaka T, Lyashkov A, Basisty N, Schilling B, Semba RD, Franceschi C, Gorospe M, Ferrucci L. Proteomics in aging research: a roadmap to clinical, translational research. Aging Cell. 2021;20:e13325.","journal-title":"Aging Cell"},{"key":"1291_CR7","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/j.jalz.2019.09.004","volume":"16","author":"FM Elahi","year":"2020","unstructured":"Elahi FM, Casaletto KB, La Joie R, Walters SM, Harvey D, Wolf A, Edwards L, Rivera-Contreras W, Karydas A, Cobigo Y, Rosen HJ, DeCarli C, Miller BL, Rabinovici GD, Kramer JH. Plasma biomarkers of astrocytic and neuronal dysfunction in early- and late-onset Alzheimer\u2019s disease. Alzheimers Dement. 2020;16:681\u201395.","journal-title":"Alzheimers Dement"},{"key":"1291_CR8","doi-asserted-by":"publisher","first-page":"e12240","DOI":"10.1002\/dad2.12240","volume":"13","author":"L Shi","year":"2021","unstructured":"Shi L, Buchanan CR, Cox SR, Hillary RF, Marioni RE, Campbell A, Hayward C, Stolicyn A, Whalley HC, Harris MA, Waymont J, Waiter G, Backhouse E, Wardlaw JM, Steele D, McIntosh A, Lovestone S, Buckley NJ, Nevado-Holgado AJ. Identification of plasma proteins relating to brain neurodegeneration and vascular pathology in cognitively normal individuals. Alzheimers Dement (Amst). 2021;13:e12240.","journal-title":"Alzheimers Dement (Amst)"},{"key":"1291_CR9","doi-asserted-by":"publisher","first-page":"193","DOI":"10.3233\/JAD-220399","volume":"89","author":"J Timsina","year":"2022","unstructured":"Timsina J, Gomez-Fonseca D, Wang L, Do A, Western D, Alvarez I, Aguilar M, Pastor P, Henson RL, Herries E. Comparative analysis of Alzheimer\u2019s disease cerebrospinal fluid biomarkers measurement by multiplex SOMAscan platform and immunoassay-based approach 1. J Alzheimers Dis. 2022;89:193\u2013207.","journal-title":"J Alzheimers Dis"},{"key":"1291_CR10","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.nbd.2013.09.011","volume":"62","author":"HY Agbemenyah","year":"2014","unstructured":"Agbemenyah HY, Agis-Balboa RC, Burkhardt S, Delalle I, Fischer A. Insulin growth factor binding protein 7 is a novel target to treat dementia. Neurobiol Dis. 2014;62:135\u201343.","journal-title":"Neurobiol Dis"},{"key":"1291_CR11","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1093\/brain\/awu318","volume":"138","author":"G Cantarella","year":"2015","unstructured":"Cantarella G, Di Benedetto G, Puzzo D, Privitera L, Loreto C, Saccone S, Giunta S, Palmeri A, Bernardini R. Neutralization of TNFSF10 ameliorates functional outcome in a murine model of Alzheimer\u2019s disease. Brain. 2015;138:203\u201316.","journal-title":"Brain"},{"key":"1291_CR12","doi-asserted-by":"publisher","first-page":"621","DOI":"10.3233\/JAD-2010-1253","volume":"19","author":"X Cheng","year":"2010","unstructured":"Cheng X, Yang L, He P, Li R, Shen Y. Differential activation of tumor necrosis factor receptors distinguishes between brains from Alzheimer\u2019s disease and non-demented patients. J Alzheimers Dis. 2010;19:621\u201330.","journal-title":"J Alzheimers Dis"},{"key":"1291_CR13","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.bbrc.2015.03.082","volume":"460","author":"W Tan","year":"2015","unstructured":"Tan W, Pu Y, Shao Q, Fang X, Han D, Zhao M, Cao L. Insulin-like growth factor-binding protein 7 is up-regulated during EAE and inhibits the differentiation of oligodendrocyte precursor cells. Biochem Biophys Res Commun. 2015;460:639\u201344.","journal-title":"Biochem Biophys Res Commun"},{"key":"1291_CR14","doi-asserted-by":"publisher","first-page":"453","DOI":"10.2169\/internalmedicine.54.2876","volume":"54","author":"I-U Song","year":"2015","unstructured":"Song I-U, Kim Y-D, Chung S-W, Cho H-J. Association between serum haptoglobin and the pathogenesis of Alzheimer\u2019s disease. Intern Med. 2015;54:453\u20137.","journal-title":"Intern Med"},{"key":"1291_CR15","doi-asserted-by":"publisher","first-page":"1868","DOI":"10.1016\/j.freeradbiomed.2012.08.596","volume":"53","author":"A Cocciolo","year":"2012","unstructured":"Cocciolo A, Di Domenico F, Coccia R, Fiorini A, Cai J, Pierce W, Mecocci P, Butterfield D, Perluigi M. Decreased expression and increased oxidation of plasma haptoglobin in Alzheimer disease: insights from redox proteomics. Free Radical Biol Med. 2012;53:1868\u201376.","journal-title":"Free Radical Biol Med"},{"key":"1291_CR16","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1038\/s41593-018-0234-x","volume":"21","author":"MD Sweeney","year":"2018","unstructured":"Sweeney MD, Kisler K, Montagne A, Toga AW, Zlokovic BV. The role of brain vasculature in neurodegenerative disorders. Nat Neurosci. 2018;21:1318\u201331.","journal-title":"Nat Neurosci"},{"key":"1291_CR17","doi-asserted-by":"publisher","first-page":"2131","DOI":"10.1523\/JNEUROSCI.0949-21.2021","volume":"42","author":"R de Flores","year":"2022","unstructured":"de Flores R, Das SR, Xie L, Wisse LE, Lyu X, Shah P, Yushkevich PA, Wolk DA. Medial temporal lobe networks in Alzheimer\u2019s disease: structural and molecular vulnerabilities. J Neurosci. 2022;42:2131\u201341.","journal-title":"J Neurosci"},{"key":"1291_CR18","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1038\/nrneurol.2013.164","volume":"9","author":"RN Kalaria","year":"2013","unstructured":"Kalaria RN, Ihara M. Vascular and neurodegenerative pathways\u2014will they meet? Nat Rev Neurol. 2013;9:487\u20138.","journal-title":"Nat Rev Neurol"},{"issue":"6","key":"1291_CR19","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/s43587-023-00405-1","volume":"3","author":"L Montoliu-Gaya","year":"2023","unstructured":"Montoliu-Gaya L, Benedet AL, Tissot C, Vrillon A, Ashton NJ, Brum WS, Lantero-Rodriguez J, Stevenson J, Nilsson J, Sauer M, Rahmouni N. Mass spectrometric simultaneous quantification of tau species in plasma shows differential associations with amyloid and tau pathologies. Nature Aging. 2023;3(6):661\u20139.","journal-title":"Nature Aging"},{"key":"1291_CR20","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","volume":"14","author":"CR Jack Jr","year":"2018","unstructured":"Jack CR Jr, Bennett DA, Blennow K, Carrillo MC, Dunn B, Haeberlein SB, Holtzman DM, Jagust W, Jessen F, Karlawish J. NIA-AA research framework: toward a biological definition of Alzheimer\u2019s disease. Alzheimers Dement. 2018;14:535\u201362.","journal-title":"Alzheimers Dement"},{"key":"1291_CR21","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","volume":"7","author":"GM McKhann","year":"2011","unstructured":"McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR Jr, Kawas CH, Klunk WE, Koroshetz WJ, Manly JJ, Mayeux R. The diagnosis of dementia due to Alzheimer\u2019s disease: recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease. Alzheimers Dement. 2011;7:263\u20139.","journal-title":"Alzheimers Dement"},{"key":"1291_CR22","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.jalz.2011.03.008","volume":"7","author":"MS Albert","year":"2011","unstructured":"Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, Gamst A, Holtzman DM, Jagust WJ, Petersen RC. The diagnosis of mild cognitive impairment due to Alzheimer\u2019s disease: recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease. Alzheimers Dement. 2011;7:270\u20139.","journal-title":"Alzheimers Dement"},{"key":"1291_CR23","doi-asserted-by":"publisher","first-page":"2336","DOI":"10.1016\/j.ajhg.2021.10.009","volume":"108","author":"Z He","year":"2021","unstructured":"He Z, Le Guen Y, Liu L, Lee J, Ma S, Yang AC, Liu X, Rutledge J, Losada PM, Song B. Genome-wide analysis of common and rare variants via multiple knockoffs at biobank scale, with an application to Alzheimer disease genetics. Am J Human Genetics. 2021;108:2336\u201353.","journal-title":"Am J Human Genetics"},{"key":"1291_CR24","doi-asserted-by":"publisher","first-page":"102180","DOI":"10.1016\/j.pneurobio.2021.102180","volume":"208","author":"B Lee","year":"2022","unstructured":"Lee B, Cai W, Young CB, Yuan R, Ryman S, Kim J, Santini V, Henderson VW, Poston KL, Menon V. Latent brain state dynamics and cognitive flexibility in older adults. Prog Neurobiol. 2022;208:102180.","journal-title":"Prog Neurobiol"},{"key":"1291_CR25","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.neuroimage.2014.04.074","volume":"98","author":"G Girard","year":"2014","unstructured":"Girard G, Whittingstall K, Deriche R, Descoteaux M. Towards quantitative connectivity analysis: reducing tractography biases. Neuroimage. 2014;98:266\u201378.","journal-title":"Neuroimage"},{"key":"1291_CR26","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1016\/j.neuroimage.2006.01.021","volume":"31","author":"RS Desikan","year":"2006","unstructured":"Desikan RS, S\u00e9gonne F, Fischl B, Quinn BT, Dickerson BC, Blacker D, Buckner RL, Dale AM, Maguire RP, Hyman BT. An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. Neuroimage. 2006;31:968\u201380.","journal-title":"Neuroimage"},{"key":"1291_CR27","doi-asserted-by":"publisher","first-page":"6969","DOI":"10.1113\/JP274714","volume":"595","author":"F Lin","year":"2017","unstructured":"Lin F, Ren P, Wang X, Anthony M, Tadin D, Heffner KL. Cortical thickness is associated with altered autonomic function in cognitively impaired and non-impaired older adults. J Physiol. 2017;595:6969\u201378.","journal-title":"J Physiol"},{"key":"1291_CR28","doi-asserted-by":"publisher","first-page":"11050","DOI":"10.1073\/pnas.200033797","volume":"97","author":"B Fischl","year":"2000","unstructured":"Fischl B, Dale AM. Measuring the thickness of the human cerebral cortex from magnetic resonance images. Proc Natl Acad Sci. 2000;97:11050\u20135.","journal-title":"Proc Natl Acad Sci"},{"key":"1291_CR29","doi-asserted-by":"publisher","first-page":"204","DOI":"10.3389\/fnagi.2019.00204","volume":"11","author":"P Barbier","year":"2019","unstructured":"Barbier P, Zejneli O, Martinho M, Lasorsa A, Belle V, Smet-Nocca C, Tsvetkov PO, Devred F, Landrieu I. Role of tau as a microtubule-associated protein: structural and functional aspects. Front Aging Neurosci. 2019;11:204.","journal-title":"Front Aging Neurosci"},{"key":"1291_CR30","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/S1474-4422(21)00361-6","volume":"21","author":"CE Teunissen","year":"2022","unstructured":"Teunissen CE, Verberk IMW, Thijssen EH, Vermunt L, Hansson O, Zetterberg H, van der Flier WM, Mielke MM, Del Campo M. Blood-based biomarkers for Alzheimer\u2019s disease: towards clinical implementation. Lancet Neurol. 2022;21:66\u201377.","journal-title":"Lancet Neurol"},{"key":"1291_CR31","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1097\/WAD.0000000000000223","volume":"32","author":"S Weintraub","year":"2018","unstructured":"Weintraub S, Besser L, Dodge HH, Teylan M, Ferris S, Goldstein FC, Giordani B, Kramer J, Loewenstein D, Marson D. Version 3 of the Alzheimer Disease Centers\u2019 neuropsychological test battery in the Uniform Data Set (UDS). Alzheimer Dis Assoc Disord. 2018;32:10.","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"1291_CR32","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","volume":"53","author":"ZS Nasreddine","year":"2005","unstructured":"Nasreddine ZS, Phillips NA, B\u00e9dirian V, Charbonneau S, Whitehead V, Collin I, Cummings JL, Chertkow H. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53:695\u20139.","journal-title":"J Am Geriatr Soc"},{"key":"1291_CR33","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1038\/s41598-017-01139-y","volume":"7","author":"Y Kim","year":"2017","unstructured":"Kim Y, El-Kareh R, Sun J, Yu H, Jiang X. Discriminative and distinct phenotyping by constrained tensor factorization. Sci Rep. 2017a;7:1114.","journal-title":"Sci Rep"},{"key":"1291_CR34","doi-asserted-by":"crossref","unstructured":"Kim Y, Sun J, Yu H, Jiang X. Federated tensor factorization for computational phenotyping. In: Proceedings of the 23rd ACM SIGKDD International conference on knowledge discovery and data mining. 2017;4:887\u201395.","DOI":"10.1145\/3097983.3098118"},{"key":"1291_CR35","doi-asserted-by":"publisher","first-page":"103462","DOI":"10.1016\/j.jbi.2020.103462","volume":"107","author":"Y Kim","year":"2020","unstructured":"Kim Y, Lhatoo S, Zhang G-Q, Chen L, Jiang X. Temporal phenotyping for transitional disease progress: an application to epilepsy and Alzheimer\u2019s disease. J Biomed Inform. 2020;107:103462.","journal-title":"J Biomed Inform"},{"key":"1291_CR36","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/BF02310791","volume":"35","author":"JD Carroll","year":"1970","unstructured":"Carroll JD, Chang J-J. Analysis of individual differences in multidimensional scaling via an N-way generalization of \u201cEckart-Young\u201d decomposition. Psychometrika. 1970;35:283\u2013319.","journal-title":"Psychometrika"},{"key":"1291_CR37","unstructured":"Ramsey JD, Zhang K, Glymour M, Romero RS, Huang B, Ebert-Uphoff I, Samarasinghe S, Barnes EA, Glymour C. Tetrad\u2014a toolbox for causal discovery. In: 8th international workshop on climate informatics. 2018;(1\u20134)."},{"key":"1291_CR38","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1177\/089443939100900106","volume":"9","author":"P Spirtes","year":"1991","unstructured":"Spirtes P, Glymour C. An algorithm for fast recovery of sparse causal graphs. Soc Sci Comput Rev. 1991;9:62\u201372.","journal-title":"Soc Sci Comput Rev"},{"key":"1291_CR39","unstructured":"Kalisch M, B\u00fchlman P. Estimating high-dimensional directed acyclic graphs with the PC-algorithm. J Machine Learn Res 2007;8."}],"container-title":["GeroScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11357-024-01291-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11357-024-01291-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11357-024-01291-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T17:03:48Z","timestamp":1744218228000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11357-024-01291-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,31]]},"references-count":39,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["1291"],"URL":"https:\/\/doi.org\/10.1007\/s11357-024-01291-0","relation":{},"ISSN":["2509-2723"],"issn-type":[{"type":"electronic","value":"2509-2723"}],"subject":[],"published":{"date-parts":[[2024,7,31]]},"assertion":[{"value":"16 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}