{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:27:15Z","timestamp":1790630835692,"version":"4.1.0"},"reference-count":95,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T00:00:00Z","timestamp":1727049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T00:00:00Z","timestamp":1727049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["1RF1AG062831-05"],"award-info":[{"award-number":["1RF1AG062831-05"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["2RF1AG043640-10"],"award-info":[{"award-number":["2RF1AG043640-10"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["GeroScience"],"DOI":"10.1007\/s11357-024-01353-3","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T07:03:04Z","timestamp":1727074984000},"page":"3627-3645","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["White matter lipid alterations during aging in the rhesus monkey brain"],"prefix":"10.1007","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1364-6161","authenticated-orcid":false,"given":"Christina","family":"Dimovasili","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana T.","family":"Vitantonio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryce","family":"Conner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelli L.","family":"Vaughan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Mattison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas L.","family":"Rosene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,23]]},"reference":[{"key":"1353_CR1","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/978-1-4020-8831-5_8","volume":"49","author":"M Bogdanov","year":"2008","unstructured":"Bogdanov M, Mileykovskaya E, Dowhan W. Lipids in the assembly of membrane proteins and organization of protein supercomplexes: implications for lipid-linked disorders. Subcell Biochem. 2008;49:197\u2013239.","journal-title":"Subcell Biochem"},{"issue":"10","key":"1353_CR2","doi-asserted-by":"publisher","first-page":"2322","DOI":"10.1016\/j.bbamem.2016.03.016","volume":"1858","author":"S P\u00f6yry","year":"2016","unstructured":"P\u00f6yry S, Vattulainen I. Role of charged lipids in membrane structures - insight given by simulations. Biochim Biophys Acta. 2016;1858(10):2322\u201333.","journal-title":"Biochim Biophys Acta"},{"key":"1353_CR3","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1186\/s40478-014-0150-6","volume":"2","author":"AS Don","year":"2014","unstructured":"Don AS, et al. Altered lipid levels provide evidence for myelin dysfunction in multiple system atrophy. Acta Neuropathol Commun. 2014;2:150.","journal-title":"Acta Neuropathol Commun"},{"issue":"1","key":"1353_CR4","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.plipres.2011.11.004","volume":"51","author":"MD Ledesma","year":"2012","unstructured":"Ledesma MD, Martin MG, Dotti CG. Lipid changes in the aged brain: effect on synaptic function and neuronal survival. Prog Lipid Res. 2012;51(1):23\u201335.","journal-title":"Prog Lipid Res"},{"key":"1353_CR5","doi-asserted-by":"crossref","unstructured":"Das UN. \u201cCell Membrane Theory of Senescence\u201d and the role of bioactive lipids in aging, and aging associated diseases and their therapeutic implications. Biomolecules. 2021;11(2).","DOI":"10.3390\/biom11020241"},{"issue":"5","key":"1353_CR6","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1111\/jnc.14271","volume":"144","author":"Y Hase","year":"2018","unstructured":"Hase Y, et al. White matter degeneration in vascular and other ageing-related dementias. J Neurochem. 2018;144(5):617\u201333.","journal-title":"J Neurochem"},{"key":"1353_CR7","doi-asserted-by":"publisher","first-page":"103204","DOI":"10.1016\/j.nicl.2022.103204","volume":"36","author":"M Dadar","year":"2022","unstructured":"Dadar M, et al. White matter hyperintensity distribution differences in aging and neurodegenerative disease cohorts. Neuroimage Clin. 2022;36:103204.","journal-title":"Neuroimage Clin"},{"issue":"1","key":"1353_CR8","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s40478-018-0515-3","volume":"6","author":"SE Nasrabady","year":"2018","unstructured":"Nasrabady SE, et al. White matter changes in Alzheimer\u2019s disease: a focus on myelin and oligodendrocytes. Acta Neuropathol Commun. 2018;6(1):22.","journal-title":"Acta Neuropathol Commun"},{"issue":"6","key":"1353_CR9","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1002\/ana.410210603","volume":"21","author":"RD Terry","year":"1987","unstructured":"Terry RD, DeTeresa R, Hansen LA. Neocortical cell counts in normal human adult aging. Ann Neurol. 1987;21(6):530\u20139.","journal-title":"Ann Neurol"},{"issue":"12","key":"1353_CR10","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1097\/NEN.0b013e31818fc72f","volume":"67","author":"SH Freeman","year":"2008","unstructured":"Freeman SH, et al. Preservation of neuronal number despite age-related cortical brain atrophy in elderly subjects without Alzheimer disease. J Neuropathol Exp Neurol. 2008;67(12):1205\u201312.","journal-title":"J Neuropathol Exp Neurol"},{"issue":"10","key":"1353_CR11","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.1016\/j.neurobiolaging.2007.03.022","volume":"29","author":"JJ Wisco","year":"2008","unstructured":"Wisco JJ, et al. An MRI study of age-related white and gray matter volume changes in the rhesus monkey. Neurobiol Aging. 2008;29(10):1563\u201375.","journal-title":"Neurobiol Aging"},{"issue":"3","key":"1353_CR12","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1515\/REVNEURO.2010.21.3.187","volume":"21","author":"AM Fjell","year":"2010","unstructured":"Fjell AM, Walhovd KB. Structural brain changes in aging: courses, causes and cognitive consequences. Rev Neurosci. 2010;21(3):187\u2013221.","journal-title":"Rev Neurosci"},{"issue":"4","key":"1353_CR13","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1212\/WNL.50.4.972","volume":"50","author":"CR Guttmann","year":"1998","unstructured":"Guttmann CR, et al. White matter changes with normal aging. Neurology. 1998;50(4):972\u20138.","journal-title":"Neurology"},{"key":"1353_CR14","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1196\/annals.1340.009","volume":"1064","author":"DH Salat","year":"2005","unstructured":"Salat DH, et al. Age-related changes in prefrontal white matter measured by diffusion tensor imaging. Ann N Y Acad Sci. 2005;1064:37\u201349.","journal-title":"Ann N Y Acad Sci"},{"issue":"15","key":"1353_CR15","doi-asserted-by":"publisher","first-page":"3046","DOI":"10.1002\/cne.22379","volume":"518","author":"MP Bowley","year":"2010","unstructured":"Bowley MP, et al. Age changes in myelinated nerve fibers of the cingulate bundle and corpus callosum in the rhesus monkey. J Comp Neurol. 2010;518(15):3046\u201364.","journal-title":"J Comp Neurol"},{"issue":"3","key":"1353_CR16","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1002\/(SICI)1096-9861(20000410)419:3<364::AID-CNE8>3.0.CO;2-R","volume":"419","author":"A Peters","year":"2000","unstructured":"Peters A, Moss MB, Sethares C. Effects of aging on myelinated nerve fibers in monkey primary visual cortex. J Comp Neurol. 2000;419(3):364\u201376.","journal-title":"J Comp Neurol"},{"issue":"3","key":"1353_CR17","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1002\/cne.10099","volume":"442","author":"A Peters","year":"2002","unstructured":"Peters A, Sethares C. Aging and the myelinated fibers in prefrontal cortex and corpus callosum of the monkey. J Comp Neurol. 2002;442(3):277\u201391.","journal-title":"J Comp Neurol"},{"issue":"8\u20139","key":"1353_CR18","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1023\/A:1025731309829","volume":"31","author":"A Peters","year":"2002","unstructured":"Peters A. The effects of normal aging on myelin and nerve fibers: a review. J Neurocytol. 2002;31(8\u20139):581\u201393.","journal-title":"J Neurocytol"},{"issue":"1","key":"1353_CR19","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1083\/jcb.28.1.73","volume":"28","author":"J Rosenbluth","year":"1966","unstructured":"Rosenbluth J. Redundant myelin sheaths and other ultrastructural features of the toad cerebellum. J Cell Biol. 1966;28(1):73\u201393.","journal-title":"J Cell Biol"},{"issue":"1","key":"1353_CR20","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s11357-022-00621-4","volume":"45","author":"C Dimovasili","year":"2023","unstructured":"Dimovasili C, et al. Aging compromises oligodendrocyte precursor cell maturation and efficient remyelination in the monkey brain. Geroscience. 2023;45(1):249\u201364.","journal-title":"Geroscience"},{"issue":"5","key":"1353_CR21","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1007\/s11357-011-9357-7","volume":"34","author":"SG Kohama","year":"2012","unstructured":"Kohama SG, Rosene DL, Sherman LS. Age-related changes in human and non-human primate white matter: from myelination disturbances to cognitive decline. Age (Dordr). 2012;34(5):1093\u2013110.","journal-title":"Age (Dordr)"},{"issue":"7","key":"1353_CR22","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1093\/cercor\/bhj045","volume":"16","author":"EV Sullivan","year":"2006","unstructured":"Sullivan EV, Adalsteinsson E, Pfefferbaum A. Selective age-related degradation of anterior callosal fiber bundles quantified in vivo with fiber tracking. Cereb Cortex. 2006;16(7):1030\u20139.","journal-title":"Cereb Cortex"},{"issue":"4","key":"1353_CR23","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1093\/cercor\/bhh003","volume":"14","author":"D Head","year":"2004","unstructured":"Head D, et al. Differential vulnerability of anterior white matter in nondemented aging with minimal acceleration in dementia of the Alzheimer type: evidence from diffusion tensor imaging. Cereb Cortex. 2004;14(4):410\u201323.","journal-title":"Cereb Cortex"},{"issue":"4","key":"1353_CR24","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1016\/j.cell.2014.10.011","volume":"159","author":"MS Yeung","year":"2014","unstructured":"Yeung MS, et al. Dynamics of oligodendrocyte generation and myelination in the human brain. Cell. 2014;159(4):766\u201374.","journal-title":"Cell"},{"issue":"4","key":"1353_CR25","doi-asserted-by":"publisher","first-page":"812","DOI":"10.3390\/cells9040812","volume":"9","author":"Y Poitelon","year":"2020","unstructured":"Poitelon Y, Kopec AM, Belin S. Myelin fat facts: an overview of lipids and fatty acid metabolism. Cells. 2020;9(4):812.","journal-title":"Cells"},{"issue":"1","key":"1353_CR26","first-page":"100360","volume":"4","author":"JA Barnes-V\u00e9lez","year":"2023","unstructured":"Barnes-V\u00e9lez JA, AksoyYasar FB, Hu J. Myelin lipid metabolism and its role in myelination and myelin maintenance. Innovation (Camb). 2023;4(1):100360.","journal-title":"Innovation (Camb)"},{"issue":"1","key":"1353_CR27","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/S0166-4328(96)02256-5","volume":"87","author":"JG Herndon","year":"1997","unstructured":"Herndon JG, et al. Patterns of cognitive decline in aged rhesus monkeys. Behav Brain Res. 1997;87(1):25\u201334.","journal-title":"Behav Brain Res"},{"issue":"10","key":"1353_CR28","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1016\/j.neurobiolaging.2006.07.005","volume":"28","author":"N Makris","year":"2007","unstructured":"Makris N, et al. Frontal connections and cognitive changes in normal aging rhesus monkeys: a DTI study. Neurobiol Aging. 2007;28(10):1556\u201367.","journal-title":"Neurobiol Aging"},{"key":"1353_CR29","doi-asserted-by":"publisher","first-page":"734173","DOI":"10.3389\/fnagi.2021.734173","volume":"13","author":"GA Stonebarger","year":"2021","unstructured":"Stonebarger GA, Bimonte-Nelson HA, Urbanski HF. The rhesus macaque as a translational model for neurodegeneration and Alzheimer\u2019s disease. Front Aging Neurosci. 2021;13:734173.","journal-title":"Front Aging Neurosci"},{"key":"1353_CR30","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.neuroimage.2015.05.072","volume":"117","author":"E Calabrese","year":"2015","unstructured":"Calabrese E, et al. A diffusion tensor MRI atlas of the postmortem rhesus macaque brain. Neuroimage. 2015;117:408\u201316.","journal-title":"Neuroimage"},{"key":"1353_CR31","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.neurobiolaging.2023.02.002","volume":"126","author":"S Dash","year":"2023","unstructured":"Dash S, et al. Brain volumetrics across the lifespan of the rhesus macaque. Neurobiol Aging. 2023;126:34\u201343.","journal-title":"Neurobiol Aging"},{"key":"1353_CR32","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.neurobiolaging.2024.02.014","volume":"139","author":"YS Liu","year":"2024","unstructured":"Liu YS, et al. Brain age of rhesus macaques over the lifespan. Neurobiol Aging. 2024;139:73\u201381.","journal-title":"Neurobiol Aging"},{"issue":"3","key":"1353_CR33","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1111\/j.1600-0684.1997.tb00042.x","volume":"26","author":"JL VandeBerg","year":"1997","unstructured":"VandeBerg JL, Williams-Blangero S. Advantages and limitations of nonhuman primates as animal models in genetic research on complex diseases. J Med Primatol. 1997;26(3):113\u20139.","journal-title":"J Med Primatol"},{"issue":"1","key":"1353_CR34","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/1866-1955-4-21","volume":"4","author":"KK Watson","year":"2012","unstructured":"Watson KK, Platt ML. Of mice and monkeys: using non-human primate models to bridge mouse- and human-based investigations of autism spectrum disorders. J Neurodev Disord. 2012;4(1):21.","journal-title":"J Neurodev Disord"},{"issue":"1","key":"1353_CR35","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/S0197-4580(02)00054-4","volume":"24","author":"TL Moore","year":"2003","unstructured":"Moore TL, et al. Impairment in abstraction and set shifting in aged rhesus monkeys. Neurobiol Aging. 2003;24(1):125\u201334.","journal-title":"Neurobiol Aging"},{"key":"1353_CR36","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/1476-511X-12-68","volume":"12","author":"Y Tajima","year":"2013","unstructured":"Tajima Y, et al. Lipidomic analysis of brain tissues and plasma in a mouse model expressing mutated human amyloid precursor protein\/tau for Alzheimer\u2019s disease. Lipids Health Dis. 2013;12:68.","journal-title":"Lipids Health Dis"},{"issue":"1","key":"1353_CR37","doi-asserted-by":"publisher","first-page":"5924","DOI":"10.1038\/s41467-022-33500-9","volume":"13","author":"S Boland","year":"2022","unstructured":"Boland S, et al. Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis. Nat Commun. 2022;13(1):5924.","journal-title":"Nat Commun"},{"issue":"3","key":"1353_CR38","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1369\/0022155418815860","volume":"67","author":"RJ Maganti","year":"2019","unstructured":"Maganti RJ, et al. Defining changes in the spatial distribution and composition of brain lipids in the shiverer and cuprizone mouse models of myelin disease. J Histochem Cytochem. 2019;67(3):203\u201319.","journal-title":"J Histochem Cytochem"},{"issue":"Pt 11","key":"1353_CR39","doi-asserted-by":"publisher","first-page":"3092","DOI":"10.1093\/brain\/awn190","volume":"131","author":"D Wheeler","year":"2008","unstructured":"Wheeler D, et al. A defect of sphingolipid metabolism modifies the properties of normal appearing white matter in multiple sclerosis. Brain. 2008;131(Pt 11):3092\u2013102.","journal-title":"Brain"},{"issue":"3","key":"1353_CR40","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1002\/ajp.1350150308","volume":"15","author":"J Tigges","year":"1988","unstructured":"Tigges J, et al. Survival rate and life span of rhesus monkeys at the Yerkes regional primate research center. Am J Primatol. 1988;15(3):263\u201373.","journal-title":"Am J Primatol"},{"issue":"7","key":"1353_CR41","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1093\/clinchem\/43.7.1209","volume":"43","author":"F Nielsen","year":"1997","unstructured":"Nielsen F, et al. Plasma malondialdehyde as biomarker for oxidative stress: reference interval and effects of life-style factors. Clin Chem. 1997;43(7):1209\u201314.","journal-title":"Clin Chem"},{"issue":"11","key":"1353_CR42","doi-asserted-by":"publisher","first-page":"108132","DOI":"10.1016\/j.celrep.2020.108132","volume":"32","author":"D Fitzner","year":"2020","unstructured":"Fitzner D, et al. Cell-type- and brain-region-resolved mouse brain lipidome. Cell Rep. 2020;32(11):108132.","journal-title":"Cell Rep"},{"issue":"1","key":"1353_CR43","doi-asserted-by":"publisher","first-page":"6021","DOI":"10.1038\/s41467-021-26310-y","volume":"12","author":"J Ding","year":"2021","unstructured":"Ding J, et al. A metabolome atlas of the aging mouse brain. Nat Commun. 2021;12(1):6021.","journal-title":"Nat Commun"},{"issue":"1","key":"1353_CR44","doi-asserted-by":"publisher","first-page":"4455","DOI":"10.1038\/s41467-024-48734-y","volume":"15","author":"M Osetrova","year":"2024","unstructured":"Osetrova M, et al. Lipidome atlas of the adult human brain. Nat Commun. 2024;15(1):4455.","journal-title":"Nat Commun"},{"issue":"4","key":"1353_CR45","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1002\/glia.24329","volume":"71","author":"JD Teo","year":"2023","unstructured":"Teo JD, et al. Early microglial response, myelin deterioration and lethality in mice deficient for very long chain ceramide synthesis in oligodendrocytes. Glia. 2023;71(4):1120\u201341.","journal-title":"Glia"},{"issue":"48","key":"1353_CR46","doi-asserted-by":"publisher","first-page":"33549","DOI":"10.1074\/jbc.M109.031971","volume":"284","author":"S Imgrund","year":"2009","unstructured":"Imgrund S, et al. Adult ceramide synthase 2 (CERS2)-deficient mice exhibit myelin sheath defects, cerebellar degeneration, and hepatocarcinomas. J Biol Chem. 2009;284(48):33549\u201360.","journal-title":"J Biol Chem"},{"key":"1353_CR47","doi-asserted-by":"publisher","first-page":"1137893","DOI":"10.3389\/fnins.2023.1137893","volume":"17","author":"X Pan","year":"2023","unstructured":"Pan X, et al. Sphingolipids in neurodegenerative diseases. Front Neurosci. 2023;17:1137893.","journal-title":"Front Neurosci"},{"issue":"1","key":"1353_CR48","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s12964-021-00767-2","volume":"20","author":"T Kagan","year":"2022","unstructured":"Kagan T, et al. Ceramide from sphingomyelin hydrolysis induces neuronal differentiation, whereas de novo ceramide synthesis and sphingomyelin hydrolysis initiate apoptosis after NGF withdrawal in PC12 Cells. Cell Commun Signal. 2022;20(1):15.","journal-title":"Cell Commun Signal"},{"issue":"20","key":"1353_CR49","doi-asserted-by":"publisher","first-page":"5031","DOI":"10.3390\/ijms20205031","volume":"20","author":"S Dasgupta","year":"2019","unstructured":"Dasgupta S, Ray SK. Ceramide and sphingosine regulation of myelinogenesis: targeting serine palmitoyltransferase using microRNA in multiple sclerosis. Int J Mol Sci. 2019;20(20):5031.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"1353_CR50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0163-7827(98)00021-6","volume":"38","author":"FM Go\u00f1i","year":"1999","unstructured":"Go\u00f1i FM, Alonso A. Structure and functional properties of diacylglycerols in membranes. Prog Lipid Res. 1999;38(1):1\u201348.","journal-title":"Prog Lipid Res"},{"issue":"1","key":"1353_CR51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.chemphyslip.2007.04.003","volume":"148","author":"JC G\u00f3mez-Fern\u00e1ndez","year":"2007","unstructured":"G\u00f3mez-Fern\u00e1ndez JC, Corbal\u00e1n-Garc\u00eda S. Diacylglycerols, multivalent membrane modulators. Chem Phys Lipids. 2007;148(1):1\u201325.","journal-title":"Chem Phys Lipids"},{"key":"1353_CR52","doi-asserted-by":"publisher","first-page":"1031007","DOI":"10.3389\/fcell.2022.1031007","volume":"10","author":"MG Mart\u00edn","year":"2022","unstructured":"Mart\u00edn MG, Dotti CG. Plasma membrane and brain dysfunction of the old: do we age from our membranes? Front Cell Dev Biol. 2022;10:1031007.","journal-title":"Front Cell Dev Biol"},{"key":"1353_CR53","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.neurobiolaging.2018.02.022","volume":"67","author":"M D\u00edaz","year":"2018","unstructured":"D\u00edaz M, et al. \u201cLipid raft aging\u201d in the human frontal cortex during nonpathological aging: gender influences and potential implications in Alzheimer\u2019s disease. Neurobiol Aging. 2018;67:42\u201352.","journal-title":"Neurobiol Aging"},{"issue":"7","key":"1353_CR54","doi-asserted-by":"publisher","first-page":"e12089","DOI":"10.1002\/jev2.12089","volume":"10","author":"H Su","year":"2021","unstructured":"Su H, et al. Characterization of brain-derived extracellular vesicle lipids in Alzheimer\u2019s disease. J Extracell Vesicles. 2021;10(7):e12089.","journal-title":"J Extracell Vesicles"},{"issue":"4","key":"1353_CR55","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1046\/j.1471-4159.1994.62041578.x","volume":"62","author":"T Schmidt-Schultz","year":"1994","unstructured":"Schmidt-Schultz T, Althaus HH. Monogalactosyl diglyceride, a marker for myelination, activates oligodendroglial protein kinase C. J Neurochem. 1994;62(4):1578\u201385.","journal-title":"J Neurochem"},{"key":"1353_CR56","doi-asserted-by":"publisher","first-page":"106313","DOI":"10.1016\/j.nbd.2023.106313","volume":"187","author":"K Shing","year":"2023","unstructured":"Shing K, et al. Early whole-body mutant huntingtin lowering averts changes in proteins and lipids important for synapse function and white matter maintenance in the LacQ140 mouse model. Neurobiol Dis. 2023;187:106313.","journal-title":"Neurobiol Dis"},{"issue":"4","key":"1353_CR57","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1002\/(SICI)1098-1136(200006)30:4<319::AID-GLIA10>3.0.CO;2-T","volume":"30","author":"J Marcus","year":"2000","unstructured":"Marcus J, Dupree JL, Popko B. Effects of galactolipid elimination on oligodendrocyte development and myelination. Glia. 2000;30(4):319\u201328.","journal-title":"Glia"},{"issue":"6","key":"1353_CR58","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1111\/jnc.14335","volume":"145","author":"MO Tr\u00e9panier","year":"2018","unstructured":"Tr\u00e9panier MO, et al. Phosphatidylcholine 36:1 concentration decreases along with demyelination in the cuprizone animal model and in post-mortem multiple sclerosis brain tissue. J Neurochem. 2018;145(6):504\u201315.","journal-title":"J Neurochem"},{"issue":"1","key":"1353_CR59","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s40478-023-01544-7","volume":"11","author":"OC Marian","year":"2023","unstructured":"Marian OC, et al. Disrupted myelin lipid metabolism differentiates frontotemporal dementia caused by GRN and C9orf72 gene mutations. Acta Neuropathol Commun. 2023;11(1):52.","journal-title":"Acta Neuropathol Commun"},{"issue":"Pt A","key":"1353_CR60","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.mad.2016.05.006","volume":"161","author":"KH Tse","year":"2017","unstructured":"Tse KH, Herrup K. DNA damage in the oligodendrocyte lineage and its role in brain aging. Mech Ageing Dev. 2017;161(Pt A):37\u201350.","journal-title":"Mech Ageing Dev"},{"key":"1353_CR61","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/978-3-319-40764-7_8","volume":"949","author":"AD Roth","year":"2016","unstructured":"Roth AD, N\u00fa\u00f1ez MT. Oligodendrocytes: functioning in a delicate balance between high metabolic requirements and oxidative damage. Adv Exp Med Biol. 2016;949:167\u201381.","journal-title":"Adv Exp Med Biol"},{"key":"1353_CR62","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.neuroscience.2012.09.077","volume":"251","author":"DL Dickstein","year":"2013","unstructured":"Dickstein DL, et al. Dendritic spine changes associated with normal aging. Neuroscience. 2013;251:21\u201332.","journal-title":"Neuroscience"},{"key":"1353_CR63","doi-asserted-by":"publisher","first-page":"89","DOI":"10.3389\/fncom.2019.00089","volume":"13","author":"S Iba\u00f1ez","year":"2019","unstructured":"Iba\u00f1ez S, et al. Network models predict that pyramidal neuron hyperexcitability and synapse loss in the dlPFC lead to age-related spatial working memory impairment in rhesus monkeys. Front Comput Neurosci. 2019;13:89.","journal-title":"Front Comput Neurosci"},{"key":"1353_CR64","doi-asserted-by":"publisher","first-page":"773795","DOI":"10.3389\/fragi.2021.773795","volume":"2","author":"B Gille","year":"2021","unstructured":"Gille B, et al. Recent advances in studying age-associated lipids alterations and dietary interventions in mammals. Front Aging. 2021;2:773795.","journal-title":"Front Aging"},{"issue":"8","key":"1353_CR65","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1016\/j.molmet.2016.06.014","volume":"5","author":"C Rodriguez-Navas","year":"2016","unstructured":"Rodriguez-Navas C, Morselli E, Clegg DJ. Sexually dimorphic brain fatty acid composition in low and high fat diet-fed mice. Mol Metab. 2016;5(8):680\u20139.","journal-title":"Mol Metab"},{"issue":"4","key":"1353_CR66","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1093\/schbul\/sbs089","volume":"39","author":"BD Peters","year":"2013","unstructured":"Peters BD, et al. Polyunsaturated fatty acid concentration predicts myelin integrity in early-phase psychosis. Schizophr Bull. 2013;39(4):830\u20138.","journal-title":"Schizophr Bull"},{"key":"1353_CR67","doi-asserted-by":"publisher","first-page":"669073","DOI":"10.3389\/fnana.2021.669073","volume":"15","author":"I Balbo","year":"2021","unstructured":"Balbo I, et al. Elovl5 expression in the central nervous system of the adult mouse. Front Neuroanat. 2021;15:669073.","journal-title":"Front Neuroanat"},{"issue":"3","key":"1353_CR68","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1136\/jmedgenet-2018-105711","volume":"56","author":"N Mueller","year":"2019","unstructured":"Mueller N, et al. De novo mutation in. J Med Genet. 2019;56(3):164\u201375.","journal-title":"J Med Genet"},{"issue":"6","key":"1353_CR69","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1136\/jmedgenet-2017-105172","volume":"55","author":"A Kutkowska-Ka\u017amierczak","year":"2018","unstructured":"Kutkowska-Ka\u017amierczak A, et al. Dominant ELOVL1 mutation causes neurological disorder with ichthyotic keratoderma, spasticity, hypomyelination and dysmorphic features. J Med Genet. 2018;55(6):408\u201314.","journal-title":"J Med Genet"},{"issue":"8","key":"1353_CR70","doi-asserted-by":"publisher","first-page":"1594","DOI":"10.1016\/S0022-2275(20)32188-X","volume":"39","author":"I Bj\u00f6rkhem","year":"1998","unstructured":"Bj\u00f6rkhem I, et al. Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation. J Lipid Res. 1998;39(8):1594\u2013600.","journal-title":"J Lipid Res"},{"issue":"1","key":"1353_CR71","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1023\/A:1021635826032","volume":"28","author":"S Ando","year":"2003","unstructured":"Ando S, et al. Turnover of myelin lipids in aging brain. Neurochem Res. 2003;28(1):5\u201313.","journal-title":"Neurochem Res"},{"issue":"1","key":"1353_CR72","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/s41593-020-00757-6","volume":"24","author":"SA Berghoff","year":"2021","unstructured":"Berghoff SA, et al. Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis. Nat Neurosci. 2021;24(1):47\u201360.","journal-title":"Nat Neurosci"},{"issue":"4","key":"1353_CR73","doi-asserted-by":"publisher","first-page":"109889","DOI":"10.1016\/j.celrep.2021.109889","volume":"37","author":"SA Berghoff","year":"2021","unstructured":"Berghoff SA, et al. Neuronal cholesterol synthesis is essential for repair of chronically demyelinated lesions in mice. Cell Rep. 2021;37(4):109889.","journal-title":"Cell Rep"},{"key":"1353_CR74","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1146\/annurev-neuro-091922-034237","volume":"46","author":"G Saher","year":"2023","unstructured":"Saher G. Cholesterol metabolism in aging and age-related disorders. Annu Rev Neurosci. 2023;46:59\u201378.","journal-title":"Annu Rev Neurosci"},{"key":"1353_CR75","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2024.05.005","volume":"141","author":"AT Vitantonio","year":"2024","unstructured":"Vitantonio AT, et al. Long-term calorie restriction reduces oxidative DNA damage to oligodendroglia and promotes homeostatic microglia in the aging monkey brain. Neurobiol Aging. 2024;141:1\u201313.","journal-title":"Neurobiol Aging"},{"issue":"4","key":"1353_CR76","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1002\/ana.410340416","volume":"34","author":"P Mecocci","year":"1993","unstructured":"Mecocci P, et al. Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain. Ann Neurol. 1993;34(4):609\u201316.","journal-title":"Ann Neurol"},{"issue":"1","key":"1353_CR77","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s40035-023-00350-4","volume":"12","author":"S Shadfar","year":"2023","unstructured":"Shadfar S, et al. Redox dysregulation as a driver for DNA damage and its relationship to neurodegenerative diseases. Transl Neurodegener. 2023;12(1):18.","journal-title":"Transl Neurodegener"},{"issue":"2","key":"1353_CR78","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1111\/j.1750-3639.2009.00326.x","volume":"20","author":"A Mart\u00ednez","year":"2010","unstructured":"Mart\u00ednez A, et al. Protein targets of oxidative damage in human neurodegenerative diseases with abnormal protein aggregates. Brain Pathol. 2010;20(2):281\u201397.","journal-title":"Brain Pathol"},{"issue":"4","key":"1353_CR79","doi-asserted-by":"publisher","first-page":"880","DOI":"10.3390\/cells10040880","volume":"10","author":"KW Chung","year":"2021","unstructured":"Chung KW. Advances in understanding of the role of lipid metabolism in aging. Cells. 2021;10(4):880.","journal-title":"Cells"},{"issue":"6","key":"1353_CR80","doi-asserted-by":"publisher","first-page":"e13048","DOI":"10.1111\/acel.13048","volume":"18","author":"AA Johnson","year":"2019","unstructured":"Johnson AA, Stolzing A. The role of lipid metabolism in aging, lifespan regulation, and age-related disease. Aging Cell. 2019;18(6):e13048.","journal-title":"Aging Cell"},{"issue":"1","key":"1353_CR81","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/s40478-021-01216-4","volume":"9","author":"C Emre","year":"2021","unstructured":"Emre C, et al. Age-related changes in brain phospholipids and bioactive lipids in the APP knock-in mouse model of Alzheimer\u2019s disease. Acta Neuropathol Commun. 2021;9(1):116.","journal-title":"Acta Neuropathol Commun"},{"issue":"1","key":"1353_CR82","doi-asserted-by":"publisher","first-page":"17652","DOI":"10.1038\/s41598-017-17389-9","volume":"7","author":"H Blasco","year":"2017","unstructured":"Blasco H, et al. Lipidomics reveals cerebrospinal-fluid signatures of ALS. Sci Rep. 2017;7(1):17652.","journal-title":"Sci Rep"},{"issue":"3","key":"1353_CR83","doi-asserted-by":"publisher","first-page":"809","DOI":"10.3233\/JAD-160645","volume":"60","author":"M Kim","year":"2017","unstructured":"Kim M, et al. Association between plasma ceramides and phosphatidylcholines and hippocampal brain volume in late onset Alzheimer\u2019s disease. J Alzheimers Dis. 2017;60(3):809\u201317.","journal-title":"J Alzheimers Dis"},{"issue":"4","key":"1353_CR84","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.3233\/JAD-142925","volume":"45","author":"J Olazar\u00e1n","year":"2015","unstructured":"Olazar\u00e1n J, et al. A blood-based, 7-metabolite signature for the early diagnosis of Alzheimer\u2019s disease. J Alzheimers Dis. 2015;45(4):1157\u201373.","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"1353_CR85","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1038\/s41398-021-01362-2","volume":"11","author":"Y Liu","year":"2021","unstructured":"Liu Y, et al. Plasma lipidome is dysregulated in Alzheimer\u2019s disease and is associated with disease risk genes. Transl Psychiatry. 2021;11(1):344.","journal-title":"Transl Psychiatry"},{"issue":"1","key":"1353_CR86","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1523\/JNEUROSCI.2095-18.2018","volume":"39","author":"R McGonigal","year":"2019","unstructured":"McGonigal R, et al. Glial sulfatides and neuronal complex gangliosides are functionally interdependent in maintaining myelinating axon integrity. J Neurosci. 2019;39(1):63\u201377.","journal-title":"J Neurosci"},{"issue":"15","key":"1353_CR87","doi-asserted-by":"publisher","first-page":"6507","DOI":"10.1523\/JNEUROSCI.22-15-06507.2002","volume":"22","author":"T Ishibashi","year":"2002","unstructured":"Ishibashi T, et al. A myelin galactolipid, sulfatide, is essential for maintenance of ion channels on myelinated axon but not essential for initial cluster formation. J Neurosci. 2002;22(15):6507\u201314.","journal-title":"J Neurosci"},{"issue":"9","key":"1353_CR88","doi-asserted-by":"publisher","first-page":"3154","DOI":"10.1073\/pnas.0813110106","volume":"106","author":"Y Min","year":"2009","unstructured":"Min Y, et al. Interaction forces and adhesion of supported myelin lipid bilayers modulated by myelin basic protein. Proc Natl Acad Sci U S A. 2009;106(9):3154\u20139.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"1353_CR89","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.bbadis.2003.10.001","volume":"1688","author":"B Ohler","year":"2004","unstructured":"Ohler B, et al. Role of lipid interactions in autoimmune demyelination. Biochim Biophys Acta. 2004;1688(1):10\u20137.","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"1353_CR90","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1038\/s41531-023-00558-1","volume":"9","author":"I Kaya","year":"2023","unstructured":"Kaya I, et al. Spatial lipidomics reveals brain region-specific changes of sulfatides in an experimental MPTP Parkinson\u2019s disease primate model. NPJ Parkinsons Dis. 2023;9(1):118.","journal-title":"NPJ Parkinsons Dis"},{"key":"1353_CR91","doi-asserted-by":"publisher","first-page":"106491","DOI":"10.1016\/j.nbd.2024.106491","volume":"195","author":"I Vermeulen","year":"2024","unstructured":"Vermeulen I, et al. Spatial omics reveals molecular changes in focal cortical dysplasia type II. Neurobiol Dis. 2024;195:106491.","journal-title":"Neurobiol Dis"},{"issue":"12","key":"1353_CR92","doi-asserted-by":"publisher","first-page":"2510","DOI":"10.3945\/jn.108.096016","volume":"138","author":"WJ Lukiw","year":"2008","unstructured":"Lukiw WJ, Bazan NG. Docosahexaenoic acid and the aging brain. J Nutr. 2008;138(12):2510\u20134.","journal-title":"J Nutr"},{"key":"1353_CR93","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.addr.2020.04.009","volume":"159","author":"D van Kruining","year":"2020","unstructured":"van Kruining D, et al. Sphingolipids as prognostic biomarkers of neurodegeneration, neuroinflammation, and psychiatric diseases and their emerging role in lipidomic investigation methods. Adv Drug Deliv Rev. 2020;159:232\u201344.","journal-title":"Adv Drug Deliv Rev"},{"issue":"1","key":"1353_CR94","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1038\/s42003-022-04011-6","volume":"5","author":"P Baloni","year":"2022","unstructured":"Baloni P, et al. Multi-omic analyses characterize the ceramide\/sphingomyelin pathway as a therapeutic target in Alzheimer\u2019s disease. Commun Biol. 2022;5(1):1074.","journal-title":"Commun Biol"},{"key":"1353_CR95","doi-asserted-by":"publisher","first-page":"797320","DOI":"10.3389\/fragi.2021.797320","volume":"2","author":"S Li","year":"2021","unstructured":"Li S, Kim HE. Implications of sphingolipids on aging and age-related diseases. Front Aging. 2021;2:797320.","journal-title":"Front Aging"}],"updated-by":[{"DOI":"10.1007\/s11357-025-01620-x","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000}}],"container-title":["GeroScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11357-024-01353-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11357-024-01353-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11357-024-01353-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T13:02:50Z","timestamp":1750510970000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11357-024-01353-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,23]]},"references-count":95,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["1353"],"URL":"https:\/\/doi.org\/10.1007\/s11357-024-01353-3","relation":{},"ISSN":["2509-2723"],"issn-type":[{"value":"2509-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,23]]},"assertion":[{"value":"23 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2025","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s11357-025-01620-x","URL":"https:\/\/doi.org\/10.1007\/s11357-025-01620-x","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}