{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:20:07Z","timestamp":1792783207184,"version":"4.5.0"},"reference-count":105,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32260148"],"award-info":[{"award-number":["32260148"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31900410"],"award-info":[{"award-number":["31900410"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302957"],"award-info":[{"award-number":["82302957"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Yunnan Fundamental Research Projects","award":["202401CF070054"],"award-info":[{"award-number":["202401CF070054"]}]},{"name":"Biomedical Projects of Yunnan Key Science and Technology Program","award":["202302AA310046"],"award-info":[{"award-number":["202302AA310046"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["GeroScience"],"DOI":"10.1007\/s11357-024-01468-7","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T01:36:07Z","timestamp":1734312967000},"page":"631-651","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A complex systems approach to mosaic loss of the Y chromosome"],"prefix":"10.1007","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7911-1640","authenticated-orcid":false,"given":"Xihan","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqin","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"issue":"1","key":"1468_CR1","doi-asserted-by":"publisher","first-page":"101342","DOI":"10.1016\/j.arr.2021.101342","volume":"68","author":"X Dai","year":"2021","unstructured":"Dai X, Guo X. Decoding and rejuvenating human ageing genomes: lessons from mosaic chromosomal alterations. Ageing Res Rev. 2021;68(1):101342.","journal-title":"Ageing Res Rev"},{"issue":"6465","key":"1468_CR2","doi-asserted-by":"publisher","first-page":"eaan4673","DOI":"10.1126\/science.aan4673","volume":"366","author":"S Jaiswal","year":"2019","unstructured":"Jaiswal S, Ebert BL. Clonal hematopoiesis in human aging and disease. Science. 2019;366(6465):eaan4673.","journal-title":"Science."},{"issue":"6","key":"1468_CR3","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1038\/ng.2966","volume":"46","author":"LA Forsberg","year":"2014","unstructured":"Forsberg LA, Rasi C, Malmqvist N, Davies H, Pasupulati S, Pakalapati G, Sandgren J, de St\u00e5hl TD, Zaghlool A, Giedraitis V, et al. Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer. Nat Genet. 2014;46(6):624\u20138.","journal-title":"Nat Genet"},{"issue":"6603","key":"1468_CR4","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1126\/science.abn3100","volume":"377","author":"S Sano","year":"2022","unstructured":"Sano S, Horitani K, Ogawa H, Halvardson J, Chavkin NW, Wang Y, Sano M, Mattisson J, Hata A, Danielsson M, et al. Hematopoietic loss of Y chromosome leads to cardiac fibrosis and heart failure mortality. Science. 2022;377(6603):292\u20137.","journal-title":"Science"},{"issue":"3","key":"1468_CR5","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.153768","volume":"7","author":"Q Zhang","year":"2022","unstructured":"Zhang Q, Zhao L, Yang Y, Li S, Liu Y, Chen C. Mosaic loss of chromosome Y promotes leukemogenesis and clonal hematopoiesis. JCI Insight. 2022;7(3): e153768.","journal-title":"JCI Insight"},{"issue":"2","key":"1468_CR6","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13542","volume":"21","author":"AM Bronikowski","year":"2022","unstructured":"Bronikowski AM, Meisel RP, Biga PR, Walters JR, Mank JE, Larschan E, Wilkinson GS, Valenzuela N, Conard AM, de Magalh\u00e3es JP, et al. Sex-specific aging in animals: perspective and future directions. Aging Cell. 2022;21(2): e13542.","journal-title":"Aging Cell"},{"issue":"1","key":"1468_CR7","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1146\/annurev-genet-112414-055311","volume":"49","author":"JF Hughes","year":"2015","unstructured":"Hughes JF, Page DC. The biology and evolution of mammalian Y chromosomes. Ann Rev Genet. 2015;49(1):507\u201327.","journal-title":"Ann Rev Genet"},{"issue":"1","key":"1468_CR8","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/s13578-020-00452-w","volume":"10","author":"Y-FC Lau","year":"2020","unstructured":"Lau Y-FC. Y chromosome in health and diseases. Cell Biosci. 2020;10(1):97.","journal-title":"Cell Biosci"},{"issue":"7978","key":"1468_CR9","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1038\/s41586-023-06457-y","volume":"621","author":"A Rhie","year":"2023","unstructured":"Rhie A, Nurk S, Cechova M, Hoyt SJ, Taylor DJ, Altemose N, Hook PW, Koren S, Rautiainen M, Alexandrov IA, et al. The complete sequence of a human Y chromosome. Nature. 2023;621(7978):344\u201354.","journal-title":"Nature"},{"issue":"7978","key":"1468_CR10","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/s41586-023-06425-6","volume":"621","author":"P Hallast","year":"2023","unstructured":"Hallast P, Ebert P, Loftus M, Yilmaz F, Audano PA, Logsdon GA, Bonder MJ, Zhou W, H\u00f6ps W, Kim K, et al. Assembly of 43 human Y chromosomes reveals extensive complexity and variation. Nature. 2023;621(7978):355\u201364.","journal-title":"Nature"},{"issue":"1","key":"1468_CR11","doi-asserted-by":"publisher","first-page":"3990","DOI":"10.1038\/s41467-023-39644-6","volume":"14","author":"EA Lucotte","year":"2023","unstructured":"Lucotte EA, Gu\u00f0mundsd\u00f3ttir VB, Jensen JM, Skov L, Maci\u00e0 MC, Almstrup K, Schierup MH, Helgason A, Stefansson K. Characterizing the evolution and phenotypic impact of ampliconic Y chromosome regions. Nat Commun. 2023;14(1):3990.","journal-title":"Nat Commun"},{"issue":"10","key":"1468_CR12","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1038\/s41588-023-01490-z","volume":"55","author":"CJ Watson","year":"2023","unstructured":"Watson CJ, Blundell JR. Mutation rates and fitness consequences of mosaic chromosomal alterations in blood. Nat Genet. 2023;55(10):1677\u201385.","journal-title":"Nat Genet"},{"issue":"7913","key":"1468_CR13","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1038\/s41586-022-04786-y","volume":"606","author":"E Mitchell","year":"2022","unstructured":"Mitchell E, Spencer CM, Williams N, Dawson KJ, Mende N, Calderbank EF, Jung H, Mitchell T, Coorens THH, Spencer DH, et al. Clonal dynamics of haematopoiesis across the human lifespan. Nature. 2022;606(7913):343\u201350.","journal-title":"Nature"},{"issue":"3","key":"1468_CR14","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.devcel.2015.03.020","volume":"33","author":"D Fachinetti","year":"2015","unstructured":"Fachinetti D, Han JS, McMahon MA, Ly P, Abdullah A, Wong AJ, Cleveland DW, DNA,. sequence-specific binding of CENP-B enhances the fidelity of human centromere function. Dev Cell. 2015;33(3):314\u201327.","journal-title":"Dev Cell"},{"issue":"8010","key":"1468_CR15","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1038\/s41586-024-07278-3","volume":"629","author":"GA Logsdon","year":"2024","unstructured":"Logsdon GA, Rozanski AN, Ryabov F, Potapova T, Shepelev VA, Catacchio CR, Porubsky D, Mao Y, Yoo D, Rautiainen M, et al. The variation and evolution of complete human centromeres. Nature. 2024;629(8010):136\u201345.","journal-title":"Nature"},{"issue":"4","key":"1468_CR16","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/S0168-9525(97)01098-6","volume":"13","author":"D Kipling","year":"1997","unstructured":"Kipling D, Warburton PE. Centromeres, CENP-B and Tigger too. Trends Genet. 1997;13(4):141\u20135.","journal-title":"Trends Genet"},{"issue":"4","key":"1468_CR17","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1007\/s00439-020-02114-w","volume":"139","author":"X Guo","year":"2020","unstructured":"Guo X, Dai X, Zhou T, Wang H, Ni J, Xue J, Wang X. Mosaic loss of human Y chromosome: what, how and why. Hum Genet. 2020;139(4):421\u201346.","journal-title":"Hum Genet"},{"issue":"2","key":"1468_CR18","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1002\/ajmg.1320530204","volume":"53","author":"LYF Hsu","year":"1994","unstructured":"Hsu LYF. Phenotype\/karyotype correlations of Y chromosome aneuploidy with emphasis on structural aberrations in postnatally diagnosed cases. Am J Med Genet. 1994;53(2):108\u201340.","journal-title":"Am J Med Genet"},{"issue":"5","key":"1468_CR19","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/j.cell.2009.07.042","volume":"138","author":"J Lange","year":"2009","unstructured":"Lange J, Skaletsky H, van Daalen SK, Embry SL, Korver CM, Brown LG, Oates RD, Silber S, Repping S, Page DC. Isodicentric Y chromosomes and sex disorders as byproducts of homologous recombination that maintains palindromes. Cell. 2009;138(5):855\u201369.","journal-title":"Cell"},{"issue":"12","key":"1468_CR20","doi-asserted-by":"publisher","first-page":"2559","DOI":"10.1093\/humrep\/15.12.2559","volume":"15","author":"JP Siffroi","year":"2000","unstructured":"Siffroi JP, Le Bourhis C, Krausz C, Barbaux S, Quintana-Murci L, Kanafani S, Rouba H, Bujan L, Bourrouillou G, Seifer I, et al. Sex chromosome mosaicism in males carrying Y chromosome long arm deletions. Hum Reprod. 2000;15(12):2559\u201362.","journal-title":"Hum Reprod"},{"issue":"2","key":"1468_CR21","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1002\/ajmg.a.30712","volume":"135","author":"PC Patsalis","year":"2005","unstructured":"Patsalis PC, Skordis N, Sismani C, Kousoulidou L, Koumbaris G, Eftychi C, Stavrides G, Ioulianos A, Kitsiou-Tzeli S, Galla-Voumvouraki A. Identification of high frequency of Y chromosome deletions in patients with sex chromosome mosaicism and correlation with the clinical phenotype and Y-chromosome instability. Am J Med Genet A. 2005;135(2):145\u20139.","journal-title":"Am J Med Genet A"},{"issue":"1","key":"1468_CR22","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s12610-023-00212-z","volume":"33","author":"J Fedder","year":"2023","unstructured":"Fedder J, Fagerberg C, J\u00f8rgensen MW, Gravholt CH, Berglund A, Knudsen UB, Skakkeb\u00e6k A. Complete or partial loss of the Y chromosome in an unselected cohort of 865 non-vasectomized, azoospermic men. Basic Clin Androl. 2023;33(1):37.","journal-title":"Basic Clin Androl"},{"issue":"1\u20136","key":"1468_CR23","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/0921-8734(95)00016-Y","volume":"338","author":"JF Stone","year":"1995","unstructured":"Stone JF, Sandberg AA. Sex chromosome aneuploidy and aging. Mutat Res DNAging. 1995;338(1\u20136):107\u201313.","journal-title":"Mutat Res DNAging"},{"issue":"6695","key":"1468_CR24","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1126\/science.ado0431","volume":"384","author":"K Karimian","year":"2024","unstructured":"Karimian K, Groot A, Huso V, Kahidi R, Tan K-T, Sholes S, Keener R, McDyer JF, Alder JK, Li H, et al. Human telomere length is chromosome end\u2013specific and conserved across individuals. Science. 2024;384(6695):533\u20139.","journal-title":"Science"},{"issue":"3\u20134","key":"1468_CR25","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1159\/000089870","volume":"112","author":"S Mayer","year":"2006","unstructured":"Mayer S, Br\u00fcderlein S, Perner S, Waibel I, Holdenried A, Ciloglu N, Hasel C, Mattfeldt T, Nielsen KV, M\u00f6ller P. Sex-specific telomere length profiles and age-dependent erosion dynamics of individual chromosome arms in humans. Cytogenet Genome Res. 2006;112(3\u20134):194\u2013201.","journal-title":"Cytogenet Genome Res"},{"issue":"6706","key":"1468_CR26","doi-asserted-by":"publisher","first-page":"eadn5529","DOI":"10.1126\/science.adn5529","volume":"385","author":"O Takenouchi","year":"2024","unstructured":"Takenouchi O, Sakakibara Y, Kitajima TS. Live chromosome identifying and tracking reveals size-based spatial pathway of meiotic errors in oocytes. Science. 2024;385(6706):eadn5529.","journal-title":"Science."},{"issue":"7919","key":"1468_CR27","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1038\/s41586-022-04938-0","volume":"607","author":"SJ Klaasen","year":"2022","unstructured":"Klaasen SJ, Truong MA, van Jaarsveld RH, Koprivec I, \u0160timac V, de Vries SG, Risteski P, Kodba S, Vuku\u0161i\u0107 K, de Luca KL, et al. Nuclear chromosome locations dictate segregation error frequencies. Nature. 2022;607(7919):604\u20139.","journal-title":"Nature"},{"issue":"10","key":"1468_CR28","doi-asserted-by":"publisher","first-page":"2316","DOI":"10.1002\/ijc.27924","volume":"132","author":"PHG Duijf","year":"2013","unstructured":"Duijf PHG, Schultz N, Benezra R. Cancer cells preferentially lose small chromosomes. Int J Cancer. 2013;132(10):2316\u201326.","journal-title":"Int J Cancer"},{"key":"1468_CR29","doi-asserted-by":"publisher","first-page":"7970","DOI":"10.1101\/2024.1109.1119.613876","volume":"619","author":"J Fischer","year":"2024","unstructured":"Fischer J, Shutta K, Chen C, Fanfani V, Saha E, Mandros P, Ben GM, Xiu J, Nieva J, Liu S, et al. Selective loss of Y chromosomes in lung adenocarcinoma modulates the tumor immune environment through cancer\/testis antigens. bioRxiv. 2024;619:7970. https:\/\/doi.org\/10.1101\/2024.1109.1119.613876.","journal-title":"bioRxiv"},{"issue":"7784","key":"1468_CR30","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1038\/s41586-019-1765-3","volume":"575","author":"DJ Thompson","year":"2019","unstructured":"Thompson DJ, Genovese G, Halvardson J, Ulirsch JC, Wright DJ, Terao C, Davidsson OB, Day FR, Sulem P, Jiang Y, et al. Genetic predisposition to mosaic Y chromosome loss in blood. Nature. 2019;575(7784):652\u20137.","journal-title":"Nature"},{"issue":"3","key":"1468_CR31","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/s41431-019-0533-z","volume":"28","author":"M Danielsson","year":"2020","unstructured":"Danielsson M, Halvardson J, Davies H, Moghadam BT, Mattisson J, Rychlicka-Buniowska E, Jaszczy\u0144ski J, Heintz J, Lannfelt L, Giedraitis V, et al. Longitudinal changes in the frequency of mosaic chromosome Y loss in peripheral blood cells of aging men varies profoundly between individuals. Eur J Hum Genet. 2020;28(3):349\u201357.","journal-title":"Eur J Hum Genet"},{"issue":"1","key":"1468_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2024.111979","volume":"222","author":"DM Hozakowska-Roszkowska","year":"2024","unstructured":"Hozakowska-Roszkowska DM, Mengel-From J, Hristozova TK, Pedersen JK, Jeune B, Andersen-Ranberg K, Hjelmborg JVB, Christensen K, R\u00f6ttger R, Nygaard M. Mosaic loss of Y chromosome and the association to mortality in Danish men aged 56\u2013100 years. Mech Ageing Dev. 2024;222(1): 111979.","journal-title":"Mech Ageing Dev"},{"key":"1468_CR33","doi-asserted-by":"crossref","unstructured":"Francis M, Gorman BR, Bigdeli TB, Genovese G, Voloudakis G, Bendl J, Zeng B, Venkatesh S, Chatzinakos C, McAuley E et al. Multi-ancestry genome-wide association meta-analysis of mosaic loss of chromosome Y in the Million Veteran Program identifies 167 novel loci. medRxiv. 2024;2024.2004.2024.24306301.","DOI":"10.1101\/2024.04.24.24306301"},{"issue":"5","key":"1468_CR34","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1038\/ng.3821","volume":"49","author":"DJ Wright","year":"2017","unstructured":"Wright DJ, Day FR, Kerrison ND, Zink F, Cardona A, Sulem P, Thompson DJ, Sigurjonsdottir S, Gudbjartsson DF, Helgason A, et al. Genetic variants associated with mosaic Y chromosome loss highlight cell cycle genes and overlap with cancer susceptibility. Nat Genet. 2017;49(5):674\u20139.","journal-title":"Nat Genet"},{"issue":"1","key":"1468_CR35","doi-asserted-by":"publisher","first-page":"4719","DOI":"10.1038\/s41467-019-12705-5","volume":"10","author":"C Terao","year":"2019","unstructured":"Terao C, Momozawa Y, Ishigaki K, Kawakami E, Akiyama M, Loh P-R, Genovese G, Sugishita H, Ohta T, Hirata M, et al. GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation. Nat Commun. 2019;10(1):4719.","journal-title":"Nat Commun"},{"issue":"1","key":"1468_CR36","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/s41572-019-0113-0","volume":"5","author":"AMR Taylor","year":"2019","unstructured":"Taylor AMR, Rothblum-Oviatt C, Ellis NA, Hickson ID, Meyer S, Crawford TO, Smogorzewska A, Pietrucha B, Weemaes C, Stewart GS. Chromosome instability syndromes. Nat Rev Dis Primers. 2019;5(1):64.","journal-title":"Nat Rev Dis Primers"},{"issue":"5","key":"1468_CR37","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1038\/ng.3545","volume":"48","author":"W Zhou","year":"2016","unstructured":"Zhou W, Machiela MJ, Freedman ND, Rothman N, Malats N, Dagnall C, Caporaso N, Teras LT, Gaudet MM, Gapstur SM, et al. Mosaic loss of chromosome Y is associated with common variation near TCL1A. Nat Genet. 2016;48(5):563\u20138.","journal-title":"Nat Genet"},{"issue":"1","key":"1468_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2021.108389","volume":"788","author":"X Guo","year":"2021","unstructured":"Guo X, Li J, Xue J, Fenech M, Wang X. Loss of Y chromosome: an emerging next-generation biomarker for disease prediction and early detection? Mutat. Res Rev Mutat Res. 2021;788(1): 108389.","journal-title":"Res Rev Mutat Res"},{"issue":"8","key":"1468_CR39","doi-asserted-by":"publisher","first-page":"4019","DOI":"10.1007\/s00018-021-03822-w","volume":"78","author":"JP Dumanski","year":"2021","unstructured":"Dumanski JP, Halvardson J, Davies H, Rychlicka-Buniowska E, Mattisson J, Moghadam BT, Nagy N, W\u0119glarczyk K, Bukowska-Strakova K, Danielsson M, et al. Immune cells lacking Y chromosome show dysregulation of autosomal gene expression. Cell Mol Life Sci. 2021;78(8):4019\u201333.","journal-title":"Cell Mol Life Sci"},{"issue":"1","key":"1468_CR40","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1186\/s12864-024-10168-7","volume":"25","author":"J Mattisson","year":"2024","unstructured":"Mattisson J, Halvardson J, Davies H, Bruhn-Olszewska B, Olszewski P, Danielsson M, Bjurling J, Lindberg A, Zaghlool A, Rychlicka-Buniowska E, et al. Loss of chromosome Y in regulatory T cells. BMC Genomics. 2024;25(1):243.","journal-title":"BMC Genomics"},{"issue":"10","key":"1468_CR41","first-page":"1795","volume":"32","author":"MC Vermeulen","year":"2022","unstructured":"Vermeulen MC, Pearse R, Young-Pearse T, Mostafavi S. Mosaic loss of chromosome Y in aged human microglia. Genome Res. 2022;32(10):1795\u2013807.","journal-title":"Genome Res"},{"issue":"1","key":"1468_CR42","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s13059-024-03173-2","volume":"25","author":"PC Wilson","year":"2024","unstructured":"Wilson PC, Verma A, Yoshimura Y, Muto Y, Li H, Malvin NP, Dixon EE, Humphreys BD. Mosaic loss of Y chromosome is associated with aging and epithelial injury in chronic kidney disease. Genome Biol. 2024;25(1):36.","journal-title":"Genome Biol"},{"issue":"5","key":"1468_CR43","doi-asserted-by":"publisher","first-page":"961","DOI":"10.3390\/cancers16050961","volume":"16","author":"W Sta\u0144kowska","year":"2024","unstructured":"Sta\u0144kowska W, Sarkisyan D, Bruhn-Olszewska B, Duzowska K, Bie\u0144kowski M, J\u0105kalski M, W\u00f3jcik-Zalewska M, Davies H, Dr\u0119\u017cek-Chy\u0142a K, P\u0119ksa R. Tumor predisposing post-zygotic chromosomal alterations in bladder cancer\u2014insights from histologically normal urothelium. Cancers. 2024;16(5):961.","journal-title":"Cancers"},{"key":"1468_CR44","doi-asserted-by":"publisher","first-page":"146345","DOI":"10.1016\/j.brainres.2019.146345","volume":"1721","author":"EJ Graham","year":"2019","unstructured":"Graham EJ, Vermeulen M, Vardarajan B, Bennet D, De Jager P, Pearse RV, Young-Pearse TL, Mostafavi S. Somatic mosaicism of sex chromosomes in the blood and brain. Brain Res. 2019;1721:146345.","journal-title":"Brain Res"},{"issue":"3","key":"1468_CR45","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1038\/s41375-021-01456-2","volume":"36","author":"V Ljungstr\u00f6m","year":"2021","unstructured":"Ljungstr\u00f6m V, Mattisson J, Halvardson J, Pandzic T, Davies H, Rychlicka-Buniowska E, Danielsson M, Lacaze P, Cavelier L, Dumanski JP, et al. Loss of Y and clonal hematopoiesis in blood\u2014two sides of the same coin? Leukemia. 2021;36(3):889\u201391.","journal-title":"Leukemia"},{"issue":"6","key":"1468_CR46","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1182\/blood-2017-02-769869","volume":"130","author":"F Zink","year":"2017","unstructured":"Zink F, Stacey SN, Norddahl GL, Frigge ML, Magnusson OT, Jonsdottir I, Thorgeirsson TE, Sigurdsson A, Gudjonsson SA, Gudmundsson J, et al. Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly. Blood. 2017;130(6):742\u201352.","journal-title":"Blood"},{"issue":"16","key":"1468_CR47","doi-asserted-by":"publisher","first-page":"eade9746","DOI":"10.1126\/sciadv.ade9746","volume":"9","author":"AAZ Dawoud","year":"2023","unstructured":"Dawoud AAZ, Tapper WJ, Cross NCP. Age-related loss of chromosome Y is associated with levels of sex hormone binding globulin and clonal hematopoiesis defined by TET2, TP53, and CBL mutations. Sci Adv. 2023;9(16):eade9746.","journal-title":"Sci Adv"},{"issue":"1","key":"1468_CR48","first-page":"555","volume":"106","author":"MM Ouseph","year":"2021","unstructured":"Ouseph MM, Hasserjian RP, Dal Cin P, Lovitch SB, Steensma DP, Nardi V, Weinberg OK. Genomic alterations in patients with somatic loss of the Y chromosome as the sole cytogenetic finding in bone marrow cells. Haematologica. 2021;106(1):555\u201364.","journal-title":"Haematologica"},{"issue":"6","key":"1468_CR49","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1038\/s41588-024-01754-2","volume":"56","author":"K Grimes","year":"2024","unstructured":"Grimes K, Jeong H, Amoah A, Xu N, Niemann J, Raeder B, Hasenfeld P, Stober C, Rausch T, Benito E, et al. Cell-type-specific consequences of mosaic structural variants in hematopoietic stem and progenitor cells. Nat Genet. 2024;56(6):1134\u201346.","journal-title":"Nat Genet"},{"issue":"1","key":"1468_CR50","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.mrrev.2009.02.001","volume":"682","author":"NO Bianchi","year":"2009","unstructured":"Bianchi NO. Y chromosome structural and functional changes in human malignant diseases. Mutat Res Rev Mutat Res. 2009;682(1):21\u20137.","journal-title":"Mutat Res Rev Mutat Res"},{"issue":"7","key":"1468_CR51","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.23260","volume":"63","author":"A Djos","year":"2024","unstructured":"Djos A, Svensson J, Gaarder J, Umapathy G, Nilsson S, Ek T, Vogt H, Georgantzi K, \u00d6ra I, Tr\u00e4ger C, et al. Loss of chromosome Y in neuroblastoma is associated with high-risk disease, 11q-deletion, and telomere maintenance. Genes Chromosomes Cancer. 2024;63(7): e23260.","journal-title":"Genes Chromosomes Cancer"},{"issue":"1","key":"1468_CR52","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1016\/j.csbj.2023.02.024","volume":"21","author":"P M\u00fcller","year":"2023","unstructured":"M\u00fcller P, Velazquez CO, Yazbeck AM, W\u00f6lwer C, Zhai W, Schumacher J, Heider D, Buettner R, Quaas A, Hillmer AM. Why loss of Y? A pan-cancer genome analysis of tumors with loss of Y chromosome. Comput Struct Biotechnol J. 2023;21(1):1573\u201383.","journal-title":"Comput Struct Biotechnol J"},{"issue":"14","key":"1468_CR53","doi-asserted-by":"publisher","first-page":"3125","DOI":"10.1016\/j.cell.2023.06.006","volume":"186","author":"M Qi","year":"2023","unstructured":"Qi M, Pang J, Mitsiades I, Lane AA, Rheinbay E. Loss of chromosome Y in primary tumors. Cell. 2023;186(14):3125\u201336.","journal-title":"Cell"},{"issue":"20","key":"1468_CR54","doi-asserted-by":"publisher","first-page":"3464","DOI":"10.1158\/0008-5472.CAN-24-1366","volume":"84","author":"NU Nair","year":"2024","unstructured":"Nair NU, Sch\u00e4ffer AA, Gertz EM, Cheng K, Zerbib J, Sahu AD, Leor G, Shulman ED, Aldape KD, Ben-David U, et al. Chromosome 7 gain compensates for chromosome 10 loss in glioma. Cancer Res. 2024;84(20):3464\u201377.","journal-title":"Cancer Res"},{"issue":"9","key":"1468_CR55","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/s41576-021-00356-6","volume":"22","author":"AJ Silver","year":"2021","unstructured":"Silver AJ, Bick AG, Savona MR. Germline risk of clonal haematopoiesis. Nat Rev Genet. 2021;22(9):603\u201317.","journal-title":"Nat Rev Genet"},{"issue":"12","key":"1468_CR56","doi-asserted-by":"publisher","first-page":"2423","DOI":"10.1016\/j.celrep.2017.05.055","volume":"19","author":"M Soto","year":"2017","unstructured":"Soto M, Raaijmakers JA, Bakker B, Spierings DCJ, Lansdorp PM, Foijer F, Medema RH. p53 prohibits propagation of chromosome segregation errors that produce structural aneuploidies. Cell Rep. 2017;19(12):2423\u201331.","journal-title":"Cell Rep"},{"issue":"1","key":"1468_CR57","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1007\/s00335-022-09970-z","volume":"34","author":"E Batdorj","year":"2023","unstructured":"Batdorj E, AlOgayil N, Zhuang QK-W, Galvez JH, Bauermeister K, Nagata K, Kimura T, Ward MA, Taketo T, Bourque G, et al. Genetic variation in the Y chromosome and sex-biased DNA methylation in somatic cells in the mouse. Mamm Genome. 2023;34(1):44\u201355.","journal-title":"Mamm Genome"},{"issue":"7970","key":"1468_CR58","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1038\/s41586-023-06254-7","volume":"619","author":"J Li","year":"2023","unstructured":"Li J, Lan Z, Liao W, Horner JW, Xu X, Liu J, Yoshihama Y, Jiang S, Shim HS, Slotnik M, et al. Histone demethylase KDM5D upregulation drives sex differences in colon cancer. Nature. 2023;619(7970):632\u20139.","journal-title":"Nature"},{"key":"1468_CR59","doi-asserted-by":"publisher","unstructured":"J\u0105kalski M, Rychlicka-Buniowska E, Davies H, Sarkisyan D, Siedlar M, Baran J, W\u0119glarczyk K, Jaszczynski J, Ry\u015b J, Gedraitis V. Loss of Y is associated with multi-omic changes in immune cells from Alzheimer\u2019s disease patients. medRxiv. 2023. https:\/\/doi.org\/10.1101\/2023.02.07.23285520.","DOI":"10.1101\/2023.02.07.23285520"},{"key":"1468_CR60","doi-asserted-by":"publisher","unstructured":"J\u0105kalski M, Bruhn-Olszewska B, Rychlicka-Buniowska E, Davies H, Sarkisyan D, Siedlar M, Baran J, W\u0119glarczyk K, Jaszczynski J, Ry\u015b J, et al. DNA methylation patterns contribute to changes of cellular differentiation pathways in leukocytes with LOY from patients with Alzheimer\u2019s disease. medRxiv. 2024. https:\/\/doi.org\/10.1101\/2024.08.19.24312211.","DOI":"10.1101\/2024.08.19.24312211"},{"issue":"3","key":"1468_CR61","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1038\/s44161-024-00441-z","volume":"3","author":"K Horitani","year":"2024","unstructured":"Horitani K, Chavkin NW, Arai Y, Wang Y, Ogawa H, Yura Y, Evans MA, Cochran JD, Thel MC, Polizio AH, et al. Disruption of the Uty epigenetic regulator locus in hematopoietic cells phenocopies the profibrotic attributes of Y chromosome loss in heart failure. Nat Cardiovasc Res. 2024;3(3):343\u201355.","journal-title":"Nat Cardiovasc Res"},{"issue":"16","key":"1468_CR62","doi-asserted-by":"publisher","first-page":"R786","DOI":"10.1016\/j.cub.2019.07.011","volume":"29","author":"NA Robertson","year":"2019","unstructured":"Robertson NA, Hillary RF, McCartney DL, Terradas-Terradas M, Higham J, Sproul D, Deary IJ, Kirschner K, Marioni RE, Chandra T. Age-related clonal haemopoiesis is associated with increased epigenetic age. Curr Biol. 2019;29(16):R786\u20137.","journal-title":"Curr Biol"},{"issue":"2","key":"1468_CR63","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3390\/ncrna10020021","volume":"10","author":"ES Westemeier-Rice","year":"2024","unstructured":"Westemeier-Rice ES, Winters MT, Rawson TW, Martinez I. More than the SRY: the non-coding landscape of the Y chromosome and its importance in human disease. Non-coding RNA. 2024;10(2):21.","journal-title":"Non-coding RNA"},{"issue":"10","key":"1468_CR64","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1161\/CIRCULATIONAHA.124.069139","volume":"150","author":"M Weyrich","year":"2024","unstructured":"Weyrich M, Cremer S, Gerster M, Sarakpi T, Rasper T, Zewinger S, Patyna SR, Leistner DM, Heine GH, Wanner C, et al. Loss of Y chromosome and cardiovascular events in chronic kidney disease. Circulation. 2024;150(10):746\u201357.","journal-title":"Circulation"},{"issue":"1","key":"1468_CR65","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s13578-024-01198-5","volume":"14","author":"L Celli","year":"2024","unstructured":"Celli L, Gasparini P, Biino G, Zannini L, Cardano M. CRISPR\/Cas9 mediated Y-chromosome elimination affects human cells transcriptome. Cell Biosci. 2024;14(1):15.","journal-title":"Cell Biosci"},{"key":"1468_CR66","doi-asserted-by":"publisher","unstructured":"Ahern DT, Bansal P, Faustino IV, Glatt-Deeley HR, Kondaveeti Y, Banda EC, Pinter SF. Isogenic hiPSC models of Turner syndrome reveal shared roles of inactive X and Y in the human cranial neural crest network. bioRxiv. 2023. https:\/\/doi.org\/10.1101\/2023.03.08.531747.","DOI":"10.1101\/2023.03.08.531747"},{"issue":"7970","key":"1468_CR67","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1038\/s41586-023-06234-x","volume":"619","author":"HA Abdel-Hafiz","year":"2023","unstructured":"Abdel-Hafiz HA, Schafer JM, Chen X, Xiao T, Gauntner TD, Li Z, Theodorescu D. Y chromosome loss in cancer drives growth by evasion of adaptive immunity. Nature. 2023;619(7970):624\u201331.","journal-title":"Nature"},{"issue":"9","key":"1468_CR68","doi-asserted-by":"publisher","first-page":"100628","DOI":"10.1016\/j.xgen.2024.100628","volume":"4","author":"LV Blanton","year":"2024","unstructured":"Blanton LV, San Roman AK, Wood G, Buscetta A, Banks N, Skaletsky H, Godfrey AK, Pham TT, Hughes JF, Brown LG, et al. Stable and robust Xi and Y transcriptomes drive cell-type-specific autosomal and Xa responses in vivo and in vitro in four human cell types. Cell Genomics. 2024;4(9):100628.","journal-title":"Cell Genomics"},{"issue":"22","key":"1468_CR69","doi-asserted-by":"publisher","first-page":"ddad133","DOI":"10.1093\/hmg\/ddad133","volume":"32","author":"AK Hubbard","year":"2023","unstructured":"Hubbard AK, Brown DW, Zhou W, Lin S-H, Genovese G, Chanock SJ, Machiela MJ. Serum biomarkers are altered in UK Biobank participants with mosaic chromosomal alterations. Hum Mol Genet. 2023;32(22):ddad133.","journal-title":"Hum Mol Genet"},{"issue":"21","key":"1468_CR70","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.1093\/eurheartj\/ehad093","volume":"44","author":"S Mas-Peiro","year":"2023","unstructured":"Mas-Peiro S, Abplanalp WT, Rasper T, Berkowitsch A, Leistner DM, Dimmeler S, Zeiher AM. Mosaic loss of Y chromosome in monocytes is associated with lower survival after transcatheter aortic valve replacement. Eur Heart J. 2023;44(21):1943\u201352.","journal-title":"Eur Heart J"},{"issue":"6","key":"1468_CR71","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1016\/j.ajhg.2016.05.014","volume":"98","author":"JP Dumanski","year":"2016","unstructured":"Dumanski JP, Lambert J-C, Rasi C, Giedraitis V, Davies H, Grenier-Boley B, Lindgren CM, Campion D, Dufouil C, Pasquier F, et al. Mosaic loss of chromosome Y in blood is associated with Alzheimer disease. Am J Hum Genet. 2016;98(6):1208\u201319.","journal-title":"Am J Hum Genet"},{"key":"1468_CR72","first-page":"2022","volume":"174","author":"EL Palmer","year":"2022","unstructured":"Palmer EL, Benchek P, Wheeler NR, Smeiszek S, Naj AC, Haines JL, Pericak-Vance MA, Forsberg LA, Cukier HN, Song Y. Somatic loss of the Y chromosome and Alzheimer\u02bcs disease risk. biorxiv. 2022;174:2022\u20132011.","journal-title":"biorxiv"},{"issue":"2","key":"1468_CR73","doi-asserted-by":"publisher","first-page":"898","DOI":"10.3390\/ijms24020898","volume":"24","author":"P Garc\u00eda-Gonz\u00e1lez","year":"2023","unstructured":"Garc\u00eda-Gonz\u00e1lez P, de Rojas I, Moreno-Grau S, Montrreal L, Puerta R, Alarc\u00f3n-Mart\u00edn E, Quintela I, Orellana A, Andrade V, Adami PVM. Mendelian randomisation confirms the role of Y-chromosome loss in Alzheimer\u2019s disease aetiopathogenesis in men. Int J Mol Sci. 2023;24(2):898.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"1468_CR74","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1038\/s41593-020-00745-w","volume":"24","author":"W-N Jin","year":"2021","unstructured":"Jin W-N, Shi K, He W, Sun J-H, Van Kaer L, Shi F-D, Liu Q. Neuroblast senescence in the aged brain augments natural killer cell cytotoxicity leading to impaired neurogenesis and cognition. Nat Neurosci. 2021;24(1):61\u201373.","journal-title":"Nat Neurosci"},{"issue":"10","key":"1468_CR75","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1038\/s41593-018-0242-x","volume":"21","author":"S Hickman","year":"2018","unstructured":"Hickman S, Izzy S, Sen P, Morsett L, El Khoury J. Microglia in neurodegeneration. Nat Neurosci. 2018;21(10):1359\u201369.","journal-title":"Nat Neurosci"},{"issue":"1","key":"1468_CR76","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1038\/s42003-024-05805-6","volume":"7","author":"LA P\u00e9rez-Jurado","year":"2024","unstructured":"P\u00e9rez-Jurado LA, C\u00e1ceres A, Balagu\u00e9-Dob\u00f3n L, Esko T, L\u00f3pez de Heredia M, Quintela I, Cruz R, Lapunzina P, Carracedo \u00c1, Abell\u00e1n J, et al. Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2. Commun Biol. 2024;7(1):202.","journal-title":"Commun Biol"},{"issue":"1","key":"1468_CR77","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1186\/s13073-022-01144-5","volume":"14","author":"B Bruhn-Olszewska","year":"2022","unstructured":"Bruhn-Olszewska B, Davies H, Sarkisyan D, Juhas U, Rychlicka-Buniowska E, W\u00f3jcik M, Horbacz M, J\u0105kalski M, Olszewski P, Westholm JO. Loss of Y in leukocytes as a risk factor for critical COVID-19 in men. Genome Med. 2022;14(1):139.","journal-title":"Genome Med"},{"issue":"1","key":"1468_CR78","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/nrc.2015.1","volume":"16","author":"LC Fern\u00e1ndez","year":"2016","unstructured":"Fern\u00e1ndez LC, Torres M, Real FX. Somatic mosaicism: on the road to cancer. Nat Rev Cancer. 2016;16(1):43\u201355.","journal-title":"Nat Rev Cancer"},{"issue":"9","key":"1468_CR79","first-page":"819","volume":"2","author":"WT Abplanalp","year":"2023","unstructured":"Abplanalp WT, Schuhmacher B, Cremer S, Merten M, Shumliakivska M, Macinkovic I, Zeiher AM, John D, Dimmeler S. Cell-intrinsic effects of clonal hematopoiesis in heart failure. Nat Cardiovasc Res. 2023;2(9):819\u201334.","journal-title":"Nat Cardiovasc Res"},{"issue":"1","key":"1468_CR80","doi-asserted-by":"publisher","first-page":"9458","DOI":"10.1038\/s41598-024-60049-y","volume":"14","author":"M W\u00f3jcik","year":"2024","unstructured":"W\u00f3jcik M, Juhas U, Mohammadi E, Mattisson J, Dr\u0119\u017cek-Chy\u0142a K, Rychlicka-Buniowska E, Bruhn-Olszewska B, Davies H, Chojnowska K, Olszewski P, et al. Loss of Y in regulatory T lymphocytes in the tumor micro-environment of primary colorectal cancers and liver metastases. Sci Rep. 2024;14(1):9458.","journal-title":"Sci Rep"},{"issue":"9","key":"1468_CR81","doi-asserted-by":"publisher","first-page":"2434","DOI":"10.1161\/STROKEAHA.123.043551","volume":"54","author":"M Dorvall","year":"2023","unstructured":"Dorvall M, Pedersen A, Dumanski JP, S\u00f6derholm M, Lindgren AG, Stanne TM, Jern C. Mosaic loss of chromosome Y is associated with functional outcome after ischemic stroke. Stroke. 2023;54(9):2434\u20137.","journal-title":"Stroke"},{"issue":"1","key":"1468_CR82","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1186\/s12888-023-04929-z","volume":"23","author":"L Jiang","year":"2023","unstructured":"Jiang L, Song M, Song F, Zhou Y, Yao H, Li G, Luo H. Characterization of loss of chromosome Y in peripheral blood cells in male Han Chinese patients with schizophrenia. BMC Psychiatry. 2023;23(1):469.","journal-title":"BMC Psychiatry"},{"key":"1468_CR83","doi-asserted-by":"crossref","unstructured":"Weng C, Zhao Y, Song M, Shao Z, Pang Y, Yu C, Pei P, Yang L, Millwood IY, Walters RG et al. Mosaic loss of chromosome Y, tobacco smoking, and risk of age-related lung diseases: insights from two prospective cohorts. Eur Respir J. 2024;2400968.","DOI":"10.1183\/13993003.00968-2024"},{"issue":"8","key":"1468_CR84","first-page":"e011681","volume":"17","author":"MC Thel","year":"2024","unstructured":"Thel MC, Cochran JD, Teruya S, Hayashi O, Xie CR, Srinivasan AR, Chavkin NW, Arai Y, Sano S, Mirabal Santos A, et al. Mosaic loss of the Y chromosome is enriched in patients with wild-type transthyretin cardiac amyloidosis and associated with increased mortality. Circulation: Heart Failure. 2024;17(8):e011681.","journal-title":"Circulation: Heart Failure"},{"issue":"1","key":"1468_CR85","doi-asserted-by":"publisher","first-page":"5536","DOI":"10.1038\/s41467-023-41315-5","volume":"14","author":"DW Brown","year":"2023","unstructured":"Brown DW, Cato LD, Zhao Y, Nandakumar SK, Bao EL, Gardner EJ, Hubbard AK, DePaulis A, Rehling T, Song L, et al. Shared and distinct genetic etiologies for different types of clonal hematopoiesis. Nat Commun. 2023;14(1):5536.","journal-title":"Nat Commun"},{"issue":"6","key":"1468_CR86","doi-asserted-by":"publisher","first-page":"e634","DOI":"10.1212\/NXG.0000000000000634","volume":"7","author":"M Johansson","year":"2021","unstructured":"Johansson M, Pedersen A, Cole JW, Lagging C, Lindgren A, Maguire JM, Rost NS, S\u00f6derholm M, Worrall BB, Stanne TM, et al. Genetic predisposition to mosaic chromosomal loss is associated with functional outcome after ischemic stroke. Neurol Genet. 2021;7(6):e634.","journal-title":"Neurol Genet"},{"key":"1468_CR87","doi-asserted-by":"crossref","unstructured":"Bae T, Fasching L, Wang Y, Shin JH, Suvakov M, Jang Y, Norton S, Dias C,\u00a0Mariani J, Jourdon A, et al. Analysis of somatic mutations in 131 human brains reveals aging-associated hypermutability.\u00a0Science. 2022;377(6605):511\u20137.","DOI":"10.1126\/science.abm6222"},{"issue":"4","key":"1468_CR88","doi-asserted-by":"publisher","first-page":"356","DOI":"10.3109\/00313021003767298","volume":"42","author":"S Minner","year":"2010","unstructured":"Minner S, Kilgu\u00e9 A, Stahl P, Weikert S, Rink M, Dahlem R, Fisch M, H\u00f6ppner W, Wagner W, Bokemeyer C. Y chromosome loss is a frequent early event in urothelial bladder cancer. Pathology. 2010;42(4):356\u20139.","journal-title":"Pathology"},{"issue":"3","key":"1468_CR89","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/s43587-024-00589-0","volume":"4","author":"CD Kapadia","year":"2024","unstructured":"Kapadia CD, Goodell MA. Tissue mosaicism following stem cell aging: blood as an exemplar. Nat Aging. 2024;4(3):295\u2013308.","journal-title":"Nat Aging"},{"issue":"4","key":"1468_CR90","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.tem.2022.01.007","volume":"33","author":"A Moskalev","year":"2022","unstructured":"Moskalev A, Guvatova Z, Lopes IDA, Beckett CW, Kennedy BK, De Magalhaes JP, Makarov AA. Targeting aging mechanisms: pharmacological perspectives. Trends Endocrinol Metab. 2022;33(4):266\u201380.","journal-title":"Trends Endocrinol Metab"},{"issue":"12","key":"1468_CR91","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1182\/blood.2022015494","volume":"141","author":"J Stachelscheid","year":"2023","unstructured":"Stachelscheid J, Jiang Q, Aszyk C, Warner K, Bley N, M\u00fcller T, Vydzhak O, Symeonidis K, Crispatzu G, Mayer P, et al. The proto-oncogene TCL1A deregulates cell cycle and genomic stability in CLL. Blood. 2023;141(12):1425\u201341.","journal-title":"Blood"},{"issue":"7958","key":"1468_CR92","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1038\/s41586-023-05806-1","volume":"616","author":"JS Weinstock","year":"2023","unstructured":"Weinstock JS, Gopakumar J, Burugula BB, Uddin MM, Jahn N, Belk JA, Bouzid H, Daniel B, Miao Z, Ly N, et al. Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis. Nature. 2023;616(7958):755\u201363.","journal-title":"Nature"},{"issue":"3","key":"1468_CR93","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.cell.2012.11.043","volume":"152","author":"Y-C Tang","year":"2013","unstructured":"Tang Y-C, Amon A. Gene copy-number alterations: a cost-benefit analysis. Cell. 2013;152(3):394\u2013405.","journal-title":"Cell"},{"issue":"7846","key":"1468_CR94","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/s41586-020-03114-6","volume":"590","author":"Y Cohen-Sharir","year":"2021","unstructured":"Cohen-Sharir Y, McFarland JM, Abdusamad M, Marquis C, Bernhard SV, Kazachkova M, Tang H, Ippolito MR, Laue K, Zerbib J, et al. Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition. Nature. 2021;590(7846):486\u201391.","journal-title":"Nature"},{"issue":"3","key":"1468_CR95","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.tips.2024.01.009","volume":"45","author":"S Bhatia","year":"2024","unstructured":"Bhatia S, Khanna KK, Duijf PHG. Targeting chromosomal instability and aneuploidy in cancer. Trends Pharmacol Sci. 2024;45(3):210\u201324.","journal-title":"Trends Pharmacol Sci"},{"issue":"9","key":"1468_CR96","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1038\/s41419-024-07087-6","volume":"15","author":"M Song","year":"2024","unstructured":"Song M, Han Y, Zhao Y, Lv J, Yu C, Pei P, Yang L, Millwood IY, Walters RG, Chen Y, et al. Association of autosomal mosaic chromosomal alterations with risk of bladder cancer in Chinese adults: a prospective cohort study. Cell Death Dis. 2024;15(9):706.","journal-title":"Cell Death Dis"},{"issue":"11","key":"1468_CR97","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1158\/1055-9965.EPI-24-0620","volume":"33","author":"CD Young","year":"2024","unstructured":"Young CD, Hubbard AK, Saint-Maurice PF, Chan ICC, Cao Y, Tran D, Bolton KL, Chanock SJ, Matthews CE, Moore SC, et al. Social, behavioral, and clinical risk factors are associated with clonal hematopoiesis. Cancer Epidemiol Biomarkers Prev. 2024;33(11):1423\u201332.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"21","key":"1468_CR98","doi-asserted-by":"publisher","first-page":"7081","DOI":"10.1007\/s00018-021-03935-2","volume":"78","author":"X Guo","year":"2021","unstructured":"Guo X. Loss of Y chromosome at the interface between aging and Alzheimer\u2019s disease. Cell Mol Life Sci. 2021;78(21):7081\u20134.","journal-title":"Cell Mol Life Sci"},{"issue":"6","key":"1468_CR99","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1038\/s41591-021-01371-0","volume":"27","author":"SM Zekavat","year":"2021","unstructured":"Zekavat SM, Lin S-H, Bick AG, Liu A, Paruchuri K, Wang C, Uddin MM, Ye Y, Yu Z, Liu X, et al. Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection. Nat Med. 2021;27(6):1012\u201324.","journal-title":"Nat Med"},{"issue":"10","key":"1468_CR100","doi-asserted-by":"publisher","first-page":"e956","DOI":"10.1097\/HS9.0000000000000956","volume":"7","author":"P Kamphuis","year":"2023","unstructured":"Kamphuis P, van Zeventer IA, de Graaf AO, Genovese G, Salzbrunn JB, Dinmohamed AG, van der Reijden BA, Schuringa JJ, Jansen JH, Huls G. Clonal hematopoiesis defined by somatic mutations infrequently co-occurs with mosaic loss of the Y chromosome in a population-based cohort. HemaSphere. 2023;7(10):e956.","journal-title":"HemaSphere"},{"issue":"8","key":"1468_CR101","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1016\/j.jtho.2023.05.001","volume":"18","author":"C Cheng","year":"2023","unstructured":"Cheng C, Hong W, Li Y, Xiao X, McKay J, Han Y, Byun J, Peng B, Albanes D, Lam S, et al. Mosaic chromosomal alterations are associated with increased lung cancer risk: insight from the INTEGRAL-ILCCO cohort analysis. J Thorac Oncol. 2023;18(8):1003\u201316.","journal-title":"J Thorac Oncol"},{"issue":"1","key":"1468_CR102","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1186\/s13578-021-00651-z","volume":"11","author":"S-H Lin","year":"2021","unstructured":"Lin S-H, Brown DW, Rose B, Day F, Lee OW, Khan SM, Hislop J, Chanock SJ, Perry JRB, Machiela MJ. Incident disease associations with mosaic chromosomal alterations on autosomes, X and Y chromosomes: insights from a phenome-wide association study in the UK Biobank. Cell Biosci. 2021;11(1):143.","journal-title":"Cell Biosci"},{"issue":"3","key":"1468_CR103","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1158\/0008-5472.CAN-18-2566","volume":"79","author":"E Loftfield","year":"2019","unstructured":"Loftfield E, Zhou W, Yeager M, Chanock SJ, Freedman ND, Machiela MJ. Mosaic Y loss is moderately associated with solid tumor risk. Cancer Res. 2019;79(3):461\u20136.","journal-title":"Cancer Res"},{"issue":"1","key":"1468_CR104","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.jtho.2018.09.013","volume":"14","author":"N Qin","year":"2019","unstructured":"Qin N, Li N, Wang C, Pu Z, Ma Z, Jin G, Zhu M, Dai M, Hu Z, Ma H, et al. Association of mosaic loss of chromosome Y with lung cancer risk and prognosis in a Chinese population. J Thorac Oncol. 2019;14(1):37\u201344.","journal-title":"J Thorac Oncol"},{"key":"1468_CR105","doi-asserted-by":"publisher","unstructured":"Uchiyama S, Ishikawa Y, Ikari K, Honda S, Hikino K, Tanaka E, Kamatani Y, Gono T, Genovese G, Kuwana M, et al. Mosaic loss of chromosome Y characterizes late-onset rheumatoid arthritis and contrasting associations of polygenic risk score based on age at onset. medRxiv. 2024. https:\/\/doi.org\/10.1101\/2024.09.12.24313215.","DOI":"10.1101\/2024.09.12.24313215"}],"container-title":["GeroScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11357-024-01468-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11357-024-01468-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11357-024-01468-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T09:14:01Z","timestamp":1740993241000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11357-024-01468-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,16]]},"references-count":105,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["1468"],"URL":"https:\/\/doi.org\/10.1007\/s11357-024-01468-7","relation":{},"ISSN":["2509-2723"],"issn-type":[{"value":"2509-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,16]]},"assertion":[{"value":"5 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Xihan Guo is assigned as corresponding author and acts on behalf of all co-authors and ensures that questions related to the accuracy or integrity of any part of the work are appropriately addressed.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosure"}}]}}