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We included 9,739 participants (54% women) aged 70+\u2009from the Tr\u00f8ndelag Health Study (HUNT4 70+). BMI was measured four times (1984\u20132019) and WC three times (1995\u20132019). Dementia diagnoses were clinically assessed at HUNT4 70+\u2009. Women and men with dementia had higher midlife BMI and WC than those without dementia. These differences diminished closer to diagnosis, especially in women. Midlife obesity in both sexes and midlife overweight, high WC, and overweight\/obesity with high WC in men were linked to higher dementia risk. Lower dementia risk was observed with late-life overweight for both sexes, late-life high WC in women, late-life overweight\/obesity with normal WC in men or high WC in women. Adiposity measures and their changes influence dementia risk differently in women and men.<\/jats:p>","DOI":"10.1007\/s11357-025-01660-3","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T22:18:08Z","timestamp":1745273888000},"page":"405-419","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Sex differences in body mass index and waist circumference trajectories and dementia risk: the HUNT4 70+\u2009study"],"prefix":"10.1007","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5777-4731","authenticated-orcid":false,"given":"Ekaterina","family":"Zotcheva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f8rn Heine","family":"Strand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vegard","family":"Skirbekk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kay","family":"Deckers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steinar","family":"Krokstad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gill","family":"Livingston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archana","family":"Singh-Manoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geir","family":"Selb\u00e6k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,22]]},"reference":[{"issue":"7","key":"1660_CR1","doi-asserted-by":"publisher","first-page":"e105","DOI":"10.1016\/s2468-2667(21)00249-8","volume":"2022","author":"GBD","year":"2019","unstructured":"GBD. 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GS has participated in Advisory Board meetings for Roche, Eli-Lilly and Eisai regarding disease-modifying drugs for Alzheimer\u2019s disease. GS has received honoraria for delivering lectures at symposia sponsored by Eisai and Eli-Lilly.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}