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The present secondary analyses from the \u201cAnthocyanins in People at Risk for Dementia Study\u201d were aimed at (I) determining the intervention\u2019s effect on blood-based markers of cardiovascular disease and inflammation and (II) evaluating whether baseline factors such as age, sex, inflammation, or cardiometabolic score may moderate the intervention\u2019s effect on inflammatory status. This study was an ancillary, 24-week randomized, double-blind, placebo-controlled Phase II trial. Sub-sample participants (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200999), aged 60\u201380\u00a0years with mild cognitive impairment or cardiometabolic disorders, were randomized to receive either 320\u00a0mg\/day of anthocyanins or placebo. The biomarkers analyzed included inflammatory biomarker assessment (IL\u2009\u2212\u20096, IL\u2009\u2212\u20098, IL\u2009\u2212\u200910, IL\u2009\u2212\u20091b, TNF\u2009\u2212\u2009\u03b1, IFN\u2009\u2212\u2009\u03b3), and C-reactive protein (CRP), as well as albumin, thrombocytes, cholesterol, LDL, HDL, and triglycerides, which were longitudinally compared between both groups. Baseline characteristics were balanced between the groups. ANCOVA analyses reveal 24-week differences favoring the anthocyanin treatment in LDL cholesterol levels (\u019ep\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.078;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.015), cardiometabolic score (\u019ep\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.073;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.021), CRP levels (\u019ep\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.417;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0001), IL\u2009\u2212\u20096 (\u019ep2\u2009=\u20090.085;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.015), IL\u2009\u2212\u20091b (\u019ep\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.058;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.037), and Inflam z-score 5 (\u019ep\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.059,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.004). Moderation analysis demonstrated that the inflammatory score at baseline was a significant predictor of the effect of the intervention on the CRP levels. Anthocyanin supplementation reduces CRP and cardiovascular disease biomarkers in individuals at risk of dementia, especially when there is increased inflammation at baseline. ClinicalTrials.gov study identifier: NCT03419039.\n                  <\/jats:p>","DOI":"10.1007\/s11357-025-01669-8","type":"journal-article","created":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T23:12:48Z","timestamp":1746141168000},"page":"563-576","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Anthocyanin supplementation in adults at risk for dementia: a randomized controlled trial on its cardiometabolic and anti-inflammatory biomarker effects"],"prefix":"10.1007","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5832-0603","authenticated-orcid":false,"given":"Miguel German","family":"Borda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robinson","family":"Ram\u00edrez-V\u00e9lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Botero-Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Patricio-Baldera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"de Lucia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Pola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George E.","family":"Barreto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khadija","family":"Khalifa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Katrine","family":"Bergland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miia","family":"Kivipelto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommy","family":"Cederholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Ashton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clive","family":"Ballard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Siow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dag","family":"Aarsland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of NJ FINGER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenni","family":"Lehtisalo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiia","family":"Ngandu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujiro","family":"Kuroda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arai","family":"Hidenori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Mangialasche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiki","family":"Sugimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuaki","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosuke","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingelin","family":"Testad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha Therese","family":"Gjestsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,2]]},"reference":[{"key":"1669_CR1","doi-asserted-by":"publisher","first-page":"1960","DOI":"10.3389\/fimmu.2017.01960","volume":"8","author":"T Fulop","year":"2017","unstructured":"Fulop T, Larbi A, Dupuis G, Le Page A, Frost EH, Cohen AA, et al. 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