{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T02:47:04Z","timestamp":1785466024637,"version":"3.56.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T00:00:00Z","timestamp":1748131200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T00:00:00Z","timestamp":1748131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100014439","name":"FONDATION ALZHEIMER","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014439","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["GeroScience"],"DOI":"10.1007\/s11357-025-01701-x","type":"journal-article","created":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T17:17:41Z","timestamp":1748193461000},"page":"1051-1062","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cognitive and neuroimaging outcome of very prodromal dementia with Lewy bodies"],"prefix":"10.1007","volume":"48","author":[{"given":"Fr\u00e9d\u00e9ric","family":"Blanc","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Bouteloup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Paquet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Chupin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Pasquier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Gabelle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Ceccaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Loureiro","family":"de Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Krolak-Salmon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaud","family":"David","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Dartigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Wallon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Moreaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Sauv\u00e9e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Belin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Roubaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Botzung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alix","family":"Ravier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Demuynck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izzie","family":"Namer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Odile","family":"Habert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Bousiges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beno\u00eet","family":"Schorr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candice","family":"Muller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Philippi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevi\u00e8ve","family":"Ch\u00eane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Cretin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Mangin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Dufouil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,25]]},"reference":[{"issue":"1","key":"1701_CR1","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1212\/WNL.0000000000004058","volume":"89","author":"IG McKeith","year":"2017","unstructured":"McKeith IG, Boeve BF, Dickson DW, Halliday G, Taylor JP, Weintraub D, Aarsland D, Galvin J, Attems J, Ballard CG, et al. Diagnosis and management of dementia with Lewy bodies: fourth consensus report of the DLB Consortium. Neurology. 2017;89(1):88\u2013100.","journal-title":"Neurology"},{"issue":"17","key":"1701_CR2","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1212\/WNL.0000000000009323","volume":"94","author":"IG McKeith","year":"2020","unstructured":"McKeith IG, Ferman TJ, Thomas AJ, Blanc F, Boeve BF, Fujishiro H, Kantarci K, Muscio C, O\u2019Brien JT, Postuma RB, et al. Research criteria for the diagnosis of prodromal dementia with Lewy bodies. Neurology. 2020;94(17):743\u201355.","journal-title":"Neurology"},{"issue":"1","key":"1701_CR3","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s13195-017-0272-8","volume":"9","author":"F Blanc","year":"2017","unstructured":"Blanc F, Mahmoudi R, Jonveaux T, Galmiche J, Chopard G, Cretin B, Demuynck C, Martin-Hunyadi C, Philippi N, Sellal F, et al. Long-term cognitive outcome of Alzheimer\u2019s disease and dementia with Lewy bodies: dual disease is worse. Alzheimer\u2019s Research & Therapy. 2017;9(1):47.","journal-title":"Alzheimer's Research & Therapy"},{"issue":"5","key":"1701_CR4","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1002\/mds.27997","volume":"35","author":"M van de Beek","year":"2020","unstructured":"van de Beek M, van Steenoven I, van der Zande JJ, Barkhof F, Teunissen CE, van der Flier WM, Lemstra AW. Prodromal dementia with Lewy bodies: clinical characterization and predictors of progression. Mov Disord. 2020;35(5):859\u201367.","journal-title":"Mov Disord"},{"issue":"3","key":"1701_CR5","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.jagp.2020.07.018","volume":"29","author":"CA Hamilton","year":"2021","unstructured":"Hamilton CA, Matthews FE, Donaghy PC, Taylor JP, O\u2019Brien JT, Barnett N, Olsen K, Lloyd J, Petrides G, McKeith IG, et al. Cognitive decline in mild cognitive impairment with Lewy bodies or Alzheimer disease: a prospective cohort study. Am J Geriatr Psychiatry. 2021;29(3):272\u201384.","journal-title":"Am J Geriatr Psychiatry"},{"issue":"1","key":"1701_CR6","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s13195-017-0288-0","volume":"9","author":"C Dufouil","year":"2017","unstructured":"Dufouil C, Dubois B, Vellas B, Pasquier F, Blanc F, Hugon J, Hanon O, Dartigues JF, Harston S, Gabelle A, et al. Cognitive and imaging markers in non-demented subjects attending a memory clinic: study design and baseline findings of the MEMENTO cohort. Alzheimers Res Ther. 2017;9(1):67.","journal-title":"Alzheimers Res Ther"},{"issue":"2","key":"1701_CR7","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1212\/WNL.62.2.181","volume":"62","author":"T Ferman","year":"2004","unstructured":"Ferman T, Smith G, Boeve B, Ivnik R, Petersen R, Knopman D, Graff-Radford N, Parisi J, Dickson D. DLB fluctuations specific features that reliably differentiate DLB from AD and normal aging. Neurology. 2004;62(2):181\u20137.","journal-title":"Neurology"},{"issue":"6","key":"1701_CR8","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1002\/mds.22839","volume":"25","author":"G Fenelon","year":"2010","unstructured":"Fenelon G, Soulas T, Zenasni F. Cleret de Langavant L: The changing face of Parkinson\u2019s disease-associated psychosis: a cross-sectional study based on the new NINDS-NIMH criteria. Mov Disord. 2010;25(6):763\u20136.","journal-title":"Mov Disord"},{"issue":"4","key":"1701_CR9","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1136\/jnnp.2007.116830","volume":"79","author":"MD Gjerstad","year":"2008","unstructured":"Gjerstad MD, Boeve B, Wentzel-Larsen T, Aarsland D, Larsen JP. Occurrence and clinical correlates of REM sleep behaviour disorder in patients with Parkinson\u2019s disease over time. J Neurol Neurosurg Psychiatry. 2008;79(4):387\u201391.","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"8","key":"1701_CR10","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1016\/S1474-4422(07)70178-3","volume":"6","author":"B Dubois","year":"2007","unstructured":"Dubois B, Feldman HH, Jacova C, Dekosky ST, Barberger-Gateau P, Cummings J, Delacourte A, Galasko D, Gauthier S, Jicha G, et al. Research criteria for the diagnosis of Alzheimer\u2019s disease: revising the NINCDS-ADRDA criteria. Lancet Neurol. 2007;6(8):734\u201346.","journal-title":"Lancet Neurol"},{"key":"1701_CR11","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1136\/jnnp-2017-316385","volume":"89","author":"O Bousiges","year":"2018","unstructured":"Bousiges O, Bombois S, Schraen S, Wallon D, Quillard MM, Gabelle A, Lehmann S, Paquet C, Amar-Bouaziz E, Magnin E, et al. Cerebrospinal fluid Alzheimer biomarkers can be useful for discriminating dementia with Lewy bodies from Alzheimer\u2019s disease at the prodromal stage. J Neurol Neurosurg Psychiatry. 2018;89:467\u201375.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"1701_CR12","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s13195-017-0288-0","volume":"9","author":"C Dufouil","year":"2017","unstructured":"Dufouil C, Dubois B, Vellas B, Pasquier F, Blanc F, Hugon J, Hanon O, Dartigues JF, Harston S, Gabelle A, et al. Cognitive and imaging markers in non-demented subjects attending a memory clinic: study design and baseline findings of the MEMENTO cohort. Alzheimers Res Ther. 2017;9:67.","journal-title":"Alzheimers Res Ther"},{"key":"1701_CR13","unstructured":"Operto G, Chupin M, Batrancourt B, Habert MO, Colliot O, Benali H, Poupon C, Champseix C, Delmaire C, Marie S et al: CATI: a large distributed infrastructure for the neuroimaging of cohorts. Neuroinformatics 2016."},{"issue":"11","key":"1701_CR14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048953","volume":"7","author":"T Samaille","year":"2012","unstructured":"Samaille T, Fillon L, Cuingnet R, Jouvent E, Chabriat H, Dormont D, Colliot O, Chupin M. Contrast-based fully automatic segmentation of white matter hyperintensities: method and validation. PLoS ONE. 2012;7(11).","journal-title":"PLoS ONE"},{"issue":"4","key":"1701_CR15","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1016\/j.neuroimage.2008.12.072","volume":"45","author":"JBS Langbaum","year":"2009","unstructured":"Langbaum JBS, Chen K, Lee W, Reschke C, Bandy D, Fleisher AS, Alexander GE, Foster NL, Weiner MW, Koeppe RA, et al. Categorical and correlational analyses of baseline fluorodeoxyglucose positron emission tomography images from the Alzheimer\u2019s Disease Neuroimaging Initiative (ADNI). Neuroimage. 2009;45(4):1107\u201316.","journal-title":"Neuroimage"},{"issue":"2","key":"1701_CR16","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s12149-017-1221-0","volume":"32","author":"M-O Habert","year":"2018","unstructured":"Habert M-O, Bertin H, Labit M, Diallo M, Marie S, Martineau K, Kas A, Causse-Lemercier V, Bakardjian H, Epelbaum S, et al. Evaluation of amyloid status in a cohort of elderly individuals with memory complaints: validation of the method of quantification and determination of positivity thresholds. Ann Nucl Med. 2018;32(2):75\u201386.","journal-title":"Ann Nucl Med"},{"issue":"1","key":"1701_CR17","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.70066","volume":"17","author":"M Verdurand","year":"2025","unstructured":"Verdurand M, Kaczorowski F, Dautricourt S, Desestret V, Formaglio M, Mollion H, Petitnicolas G, Afifi A, Fourier A, Garnier-Crussard A, et al. Toward alpha-synuclein seed amplification assay in clinical practice. Alzheimers Dement (Amst). 2025;17(1).","journal-title":"Alzheimers Dement (Amst)"},{"key":"1701_CR18","unstructured":"Van der Linden M, Coyette F, Poitrenaud J, Kalafat M, Calicis F, Wyns C, Adam S: L'\u00e9preuve de rappel libre \/ rappel indic\u00e9 \u00e0 16 items (RL\/RI-16). In., edn.: Solal; 2004: 25."},{"issue":"2","key":"1701_CR19","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/S0887-6177(03)00039-8","volume":"19","author":"TN Tombaugh","year":"2004","unstructured":"Tombaugh TN. Trail Making Test A and B: Normative data stratified by age and education. Arch Clin Neuropsychol. 2004;19(2):203\u201314.","journal-title":"Arch Clin Neuropsychol"},{"key":"1701_CR20","doi-asserted-by":"crossref","unstructured":"Morris JC: Clinical dementia rating: a reliable and valid diagnostic and staging measure for dementia of the Alzheimer type. Int Psychogeriatr 1997, 9 Suppl 1:173\u2013176; discussion 177\u2013178.","DOI":"10.1017\/S1041610297004870"},{"key":"1701_CR21","doi-asserted-by":"crossref","unstructured":"EuroQol--a new facility for the measurement of health-related quality of life. Health policy (Amsterdam, Netherlands) 1990, 16(3):199\u2013208.","DOI":"10.1016\/0168-8510(90)90421-9"},{"issue":"2","key":"1701_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v078.i02","volume":"78","author":"C Proust-Lima","year":"2017","unstructured":"Proust-Lima C, Philipps V, Liquet B. Estimation of extended mixed models using latent classes and latent processes: the R Package lcmm. J Stat Softw. 2017;78(2):1\u201356.","journal-title":"J Stat Softw"},{"issue":"5","key":"1701_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/PREACCEPT-1892765652118673","volume":"6","author":"MH Breitve","year":"2014","unstructured":"Breitve MH, Chwiszczuk LJ, Hynninen MJ, Rongve A, Br\u00f8nnick K, Janvin C, Aarsland D. A systematic review of cognitive decline in dementia with Lewy bodies versus Alzheimer\u2019s disease. Alzheimer\u2019s Research & Therapy. 2014;6(5):1\u201313.","journal-title":"Alzheimer's Research & Therapy"},{"issue":"1","key":"1701_CR24","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s13195-019-0575-z","volume":"12","author":"E Chabran","year":"2020","unstructured":"Chabran E, Noblet V. Loureiro de Sousa P, Demuynck C, Philippi N, Mutter C, Anthony P, Martin-Hunyadi C, Cretin B, Blanc F: Changes in gray matter volume and functional connectivity in dementia with Lewy bodies compared to Alzheimer\u2019s disease and normal aging: implications for fluctuations. Alzheimers Res Ther. 2020;12(1):9.","journal-title":"Alzheimers Res Ther"},{"issue":"6","key":"1701_CR25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0127396","volume":"10","author":"F Blanc","year":"2015","unstructured":"Blanc F, Colloby SJ, Philippi N, de Petigny X, Jung B, Demuynck C, Phillipps C, Anthony P, Thomas A, Bing F, et al. Cortical thickness in dementia with Lewy bodies and Alzheimer\u2019s disease: a comparison of prodromal and dementia stages. PLoS ONE. 2015;10(6).","journal-title":"PLoS ONE"},{"issue":"3\u20134","key":"1701_CR26","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1159\/000358051","volume":"38","author":"R Oesterhus","year":"2014","unstructured":"Oesterhus R, Soennesyn H, Rongve A, Ballard C, Aarsland D, Vossius C. Long-term mortality in a cohort of home-dwelling elderly with mild Alzheimer\u2019s disease and lewy body dementia. Dement Geriatr Cogn Disord. 2014;38(3\u20134):161\u20139.","journal-title":"Dement Geriatr Cogn Disord"},{"issue":"10","key":"1701_CR27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045451","volume":"7","author":"K Stubendorff","year":"2012","unstructured":"Stubendorff K, Aarsland D, Minthon L, Londos E. The impact of autonomic dysfunction on survival in patients with dementia with Lewy bodies and Parkinson\u2019s disease with dementia. PLoS ONE. 2012;7(10).","journal-title":"PLoS ONE"},{"issue":"3","key":"1701_CR28","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1093\/brain\/awaa413","volume":"144","author":"G Naasan","year":"2021","unstructured":"Naasan G, Shdo SM, Rodriguez EM, Spina S, Grinberg L, Lopez L, Karydas A, Seeley WW, Miller BL, Rankin KP. Psychosis in neurodegenerative disease: differential patterns of hallucination and delusion symptoms. Brain. 2021;144(3):999\u20131012.","journal-title":"Brain"},{"issue":"3","key":"1701_CR29","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.3233\/JAD-215198","volume":"87","author":"E Schwertner","year":"2022","unstructured":"Schwertner E, Pereira JB, Xu H, Secnik J, Winblad B, Eriksdotter M, N\u00e4gga K, Religa D. Behavioral and psychological symptoms of dementia in different dementia disorders: a large-scale study of 10,000 individuals. J Alzheimers Dis. 2022;87(3):1307\u201318.","journal-title":"J Alzheimers Dis"},{"key":"1701_CR30","doi-asserted-by":"crossref","unstructured":"Thomas AJ, Donaghy P, Roberts G, Colloby SJ, Barnett NA, Petrides G, Lloyd J, Olsen K, Taylor JP, McKeith I et al: Diagnostic accuracy of dopaminergic imaging in prodromal dementia with Lewy bodies. Psychol Med 2018:1\u20137.","DOI":"10.1017\/S0033291718000995"},{"issue":"3","key":"1701_CR31","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1007\/s00415-009-5324-y","volume":"257","author":"PT Nelson","year":"2010","unstructured":"Nelson PT, Jicha GA, Kryscio RJ, Abner EL, Schmitt FA, Cooper G, Xu LO, Smith CD, Markesbery WR. Low sensitivity in clinical diagnoses of dementia with Lewy bodies. J Neurol. 2010;257(3):359\u201366.","journal-title":"J Neurol"},{"key":"1701_CR32","doi-asserted-by":"crossref","unstructured":"McKeith IG, Ballard CG, Perry RH, Ince PG, O\u2019Brien JT, Neill D: Prospective validation of consensus criteria for the diagnosis of dementia with Lewy bodies. Neurology 2000, 54.","DOI":"10.1212\/WNL.54.5.1050"},{"issue":"2","key":"1701_CR33","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1038\/s41591-024-03469-7","volume":"31","author":"C Soto","year":"2025","unstructured":"Soto C, Mollenhauer B, Hansson O, Kang UJ, Alcalay RN, Standaert D, Trenkwalder C, Marek K, Galasko D, Poston K. Toward a biological definition of neuronal and glial synucleinopathies. Nat Med. 2025;31(2):396\u2013408.","journal-title":"Nat Med"},{"key":"1701_CR34","doi-asserted-by":"crossref","unstructured":"Fereshtehnejad SM, Yao C, Pelletier A, Montplaisir JY, Gagnon JF, Postuma RB: Evolution of prodromal Parkinson\u2019s disease and dementia with Lewy bodies: a prospective study. Brain 2019.","DOI":"10.1093\/brain\/awz111"},{"key":"1701_CR35","doi-asserted-by":"crossref","unstructured":"Ferman TJ, Boeve BF, Smith GE, Lin SC, Silber MH, Pedraza O: Inclusion of RBD improves the diagnostic classification of dementia with Lewy bodies. Neurology 2011, 77.","DOI":"10.1212\/WNL.0b013e31822c9148"}],"container-title":["GeroScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11357-025-01701-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11357-025-01701-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11357-025-01701-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T09:24:42Z","timestamp":1773048282000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11357-025-01701-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,25]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["1701"],"URL":"https:\/\/doi.org\/10.1007\/s11357-025-01701-x","relation":{},"ISSN":["2509-2723"],"issn-type":[{"value":"2509-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,25]]},"assertion":[{"value":"2 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was performed in accordance with the guidelines of the Declaration of Helsinki. Every participant provided written informed consent for the MEMENTO cohort, and the protocol was approved by the ethics committee (Comit\u00e9 de Protection des Personnes sud-ouest et outre-mer III, approval number 2010-A01394-35). The protocol is registered in ClinicalTrials.gov (Identifier: NCT01926249,\n                      \n                      ). Registration date: 16 August 2013.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"F.B. was the national coordinator for France for the Eisai Delphia (E2027), Axovant Headway-DLB and therapeutic trials Roche Graduate therapeutic trial; he had received honoraria from Roche, Eisai and Biogen for oral presentations. The other authors declare that they have no competing interests or financial disclosure related to the present work.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}