{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T11:41:34Z","timestamp":1773056494982,"version":"3.50.1"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T00:00:00Z","timestamp":1749254400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T00:00:00Z","timestamp":1749254400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"crossref","award":["2019\/24271-0"],"award-info":[{"award-number":["2019\/24271-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008914","name":"Ontario Brain Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008914","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["GeroScience"],"DOI":"10.1007\/s11357-025-01727-1","type":"journal-article","created":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T05:58:01Z","timestamp":1749275881000},"page":"1115-1126","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Subcortical white matter hyperintensities and motor function in parkinson\u2019s disease: findings from the ONDRI study"],"prefix":"10.1007","volume":"48","author":[{"given":"Daniela Cristina Carvalho","family":"de Abreu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7659-4285","authenticated-orcid":false,"given":"Frederico","family":"Pieruccini-Faria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1229-3667","authenticated-orcid":false,"given":"Anthony E.","family":"Lang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Cornish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2319-1746","authenticated-orcid":false,"given":"William","family":"McIlroy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandar","family":"Jog","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6244-2096","authenticated-orcid":false,"given":"Mario","family":"Masellis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5582-1776","authenticated-orcid":false,"given":"Joel","family":"Ramirez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean","family":"Symons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra E.","family":"Black","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0616-7771","authenticated-orcid":false,"given":"Stephen R.","family":"Arnott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9998-6612","authenticated-orcid":false,"given":"Malcolm","family":"Binns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek","family":"Beaton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6513-307X","authenticated-orcid":false,"given":"Brian","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Connie","family":"Marras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna","family":"Kwan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2115-1866","authenticated-orcid":false,"given":"David","family":"Grimes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7118-9096","authenticated-orcid":false,"given":"Robert","family":"Bartha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5796-2361","authenticated-orcid":false,"given":"Manuel","family":"Montero-Odasso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,6,7]]},"reference":[{"issue":"9996","key":"1727_CR1","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","volume":"386","author":"LV Kalia","year":"2015","unstructured":"Kalia LV, Lang AE. Parkinson\u2019s disease. Lancet. 2015;386(9996):896\u2013912. https:\/\/doi.org\/10.1016\/S0140-6736(14)61393-3.","journal-title":"Lancet"},{"key":"1727_CR2","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1038\/nrneurol.2011.21","volume":"7","author":"NI Bohnen","year":"2011","unstructured":"Bohnen NI, Albin RL. White matter lesions in Parkinson disease. Nat Rev Neurol. 2011;7:229\u201336. https:\/\/doi.org\/10.1038\/nrneurol.2011.21.","journal-title":"Nat Rev Neurol"},{"key":"1727_CR3","doi-asserted-by":"publisher","first-page":"175628641984344","DOI":"10.1177\/1756286419843447","volume":"12","author":"M Gorges","year":"2019","unstructured":"Gorges M, M\u00fcller HP, Liepelt-Scarfone I, et al. Structural brain signature of cognitive decline in Parkinson's disease: DTI-based evidence from the LANDSCAPE study. Ther Adv Neurol Disord. 2019;12:1756286419843447. https:\/\/doi.org\/10.1177\/1756286419843447.","journal-title":"Ther Adv Neurol Disord"},{"key":"1727_CR4","doi-asserted-by":"publisher","first-page":"103204","DOI":"10.1016\/j.nicl.2022.103204","volume":"36","author":"M Dadar","year":"2022","unstructured":"Dadar M, Mahmoud S, Zhernovaia M, Camicioli R, Maranzano J, Duchesne S, CCNA Group. White matter hyperintensity distribution differences in aging and neurodegenerative disease cohorts. Neuroimage Clin. 2022;36:103204. https:\/\/doi.org\/10.1016\/j.nicl.2022.103204.","journal-title":"Neuroimage Clin"},{"issue":"3","key":"1727_CR5","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1007\/s11682-018-9909-x","volume":"13","author":"V Dunet","year":"2019","unstructured":"Dunet V, Fartaria MJ, Deverdun J, et al. Episodic memory decline in Parkinson' s disease: relation with white matter hyperintense lesions and influence of quantification method. Brain Imaging Behav. 2019;13(3):810\u20138. https:\/\/doi.org\/10.1007\/s11682-018-9909-x.","journal-title":"Brain Imaging Behav"},{"issue":"6","key":"1727_CR6","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1007\/s00415-018-8838-3","volume":"265","author":"T Stojkovic","year":"2018","unstructured":"Stojkovic T, Stefanova E, Soldatovic I, et al. Exploring the relationship between motor impairment, vascular burden and cognition in Parkinson's disease. J Neurol. 2018;265(6):1320\u20137. https:\/\/doi.org\/10.1007\/s00415-018-8838-3.","journal-title":"J Neurol"},{"issue":"7","key":"1727_CR7","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1002\/mdc3.13792","volume":"10","author":"N Schr\u00f6ter","year":"2023","unstructured":"Schr\u00f6ter N, Bormann T, Rijntjes M, Blazhenets G, Berti R, Sajonz BEA, Urbach H, Weiller C, Meyer PT, Rau A, Frings L. Cognitive Deficits in Parkinson's Disease Are Associated with Neuronal Dysfunction and Not White Matter Lesions. Mov Disord Clin Pract. 2023;10(7):1066\u201373. https:\/\/doi.org\/10.1002\/mdc3.13792.","journal-title":"Mov Disord Clin Pract"},{"key":"1727_CR8","doi-asserted-by":"publisher","first-page":"1088050","DOI":"10.3389\/fnagi.2023.1088050","volume":"15","author":"I Fatokun","year":"2023","unstructured":"Fatokun I, Gee M, Nelles K, Ba F, Dadar M, Duchesne S, Sharma B, Masellis M, Black SE, Almeida QJ, Smith EE, Pieruccini-Faria F, Montero-Odasso M, Camicioli R. Dual-task gait and white matter hyperintensities in Lewy body diseases: An exploratory analysis. Front Aging Neurosci. 2023;15:1088050. https:\/\/doi.org\/10.3389\/fnagi.2023.1088050.","journal-title":"Front Aging Neurosci"},{"key":"1727_CR9","doi-asserted-by":"publisher","first-page":"785","DOI":"10.2147\/IJGM.S399307","volume":"16","author":"Z Zhang","year":"2023","unstructured":"Zhang Z, Li S, Wang S. Application of Periventricular White Matter Hyperintensities Combined with Homocysteine into Predicting Mild Cognitive Impairment in Parkinson's Disease. Int J Gen Med. 2023;16:785\u201392. https:\/\/doi.org\/10.2147\/IJGM.S399307.","journal-title":"Int J Gen Med"},{"issue":"8","key":"1727_CR10","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1111\/j.1468-1331.2012.03682.x","volume":"19","author":"R Gonz\u00e1lez-Redondo","year":"2012","unstructured":"Gonz\u00e1lez-Redondo R, Toledo J, Clavero P, et al. The impact of silent vascular brain burden in cognitive impairment in Parkinson's disease. Eur J Neurol. 2012;19(8):1100\u20137. https:\/\/doi.org\/10.1111\/j.1468-1331.2012.03682.x.","journal-title":"Eur J Neurol"},{"issue":"7","key":"1727_CR11","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1016\/j.parkreldis.2013.03.008","volume":"19","author":"N Kandiah","year":"2013","unstructured":"Kandiah N, Mak E, Ng A, et al. Cerebral white matter hyperintensity in Parkinson's disease: a major risk factor for mild cognitive impairment. Parkinsonism Relat Disord. 2013;19(7):680\u20133. https:\/\/doi.org\/10.1016\/j.parkreldis.2013.03.008.","journal-title":"Parkinsonism Relat Disord"},{"issue":"3","key":"1727_CR12","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1097\/WAD.0b013e3181d71a13","volume":"24","author":"SJ Lee","year":"2010","unstructured":"Lee SJ, Kim JS, Yoo JY, et al. Influence of white matter hyperintensities on the cognition of patients with Parkinson disease. Alzheimer Dis Assoc Disord. 2010;24(3):227\u201333. https:\/\/doi.org\/10.1097\/WAD.0b013e3181d71a13.","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"1727_CR13","doi-asserted-by":"publisher","unstructured":"Carvalho de Abreu DC, Pieruccini-Faria F, Sarquis-Adamson Y, et al. White matter hyperintensity burden predicts cognitive but not motor decline in Parkinson's disease: results from the Ontario Neurodegenerative Diseases Research Initiative. Eur J Neurol. 2023; https:\/\/doi.org\/10.1111\/ene.15692.","DOI":"10.1111\/ene.15692"},{"key":"1727_CR14","doi-asserted-by":"publisher","first-page":"105677","DOI":"10.1016\/j.neubiorev.2024.105677","volume":"161","author":"DC Carvalho de Abreu","year":"2024","unstructured":"Carvalho de Abreu DC, Pieruccini-Faria F, Son S, Montero-Odasso M, Camicioli R. Is white matter hyperintensity burden associated with cognitive and motor impairment in patients with parkinson's disease? A systematic review and meta-analysis. Neurosci Biobehav Rev. 2024;161:105677. https:\/\/doi.org\/10.1016\/j.neubiorev.2024.105677.","journal-title":"Neurosci Biobehav Rev"},{"issue":"Suppl 3","key":"1727_CR15","doi-asserted-by":"publisher","first-page":"S548","DOI":"10.1002\/mds.22062","volume":"23","author":"JA Obeso","year":"2008","unstructured":"Obeso JA, Rodr\u00edguez-Oroz MC, Benitez-Temino B, Blesa FJ, Guridi J, Marin C, Rodriguez M. Functional organization of the basal ganglia: therapeutic implications for Parkinson\u2019s disease. Mov Disord. 2008;23(Suppl 3):S548\u201359. https:\/\/doi.org\/10.1002\/mds.22062.","journal-title":"Mov Disord"},{"key":"1727_CR16","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/0166-2236(89)90074-x","volume":"12","author":"RL Albin","year":"1989","unstructured":"Albin RL, Young AB, Penney JB. The functional anatomy of basal ganglia disorders. Trend Neurosci. 1989;12:366\u201375. https:\/\/doi.org\/10.1016\/0166-2236(89)90074-x.","journal-title":"Trend Neurosci"},{"key":"1727_CR17","unstructured":"Knierim J. Neuroscience online an electronic textbook for the neurosciences. Chapter 4: Basal Ganglia. https:\/\/nba.uth.tmc.edu\/neuroscience\/m\/s3\/chapter04.html"},{"issue":"8","key":"1727_CR18","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1007\/s00381-002-0604-1","volume":"18","author":"MT Herrero","year":"2002","unstructured":"Herrero MT, Barcia C, Navarro JM. Functional anatomy of thalamus and basal ganglia. Childs Nerv Syst. 2002;18(8):386\u2013404. https:\/\/doi.org\/10.1007\/s00381-002-0604-1.","journal-title":"Childs Nerv Syst"},{"key":"1727_CR19","doi-asserted-by":"publisher","first-page":"e291","DOI":"10.1212\/WNL.0000000000009890","volume":"95","author":"Y Lee","year":"2020","unstructured":"Lee Y, Ko J, Choi YE, et al. Areas of white matter hyperintensities and motor symptoms of Parkinson disease. Neurology. 2020;95:e291\u20138. https:\/\/doi.org\/10.1212\/WNL.0000000000009890.","journal-title":"Neurology"},{"key":"1727_CR20","doi-asserted-by":"publisher","first-page":"117518","DOI":"10.1016\/j.jns.2021.117518","volume":"427","author":"E Fang","year":"2021","unstructured":"Fang E, Fartaria MJ, Ann CN, et al. Clinical correlates of white matter lesions in Parkinson's disease using automated multi-modal segmentation measures. J Neurol Sci. 2021;427:117518. https:\/\/doi.org\/10.1016\/j.jns.2021.117518.","journal-title":"J Neurol Sci"},{"issue":"1","key":"1727_CR21","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1002\/alz.12632","volume":"19","author":"KM Sunderland","year":"2023","unstructured":"Sunderland KM, et al. ONDRI Investigators. Characteristics of the Ontario Neurodegenerative Disease Research Initiative cohort. Alzheimers Dement. 2023;19(1):226\u201343. https:\/\/doi.org\/10.1002\/alz.12632.","journal-title":"Alzheimers Dement"},{"key":"1727_CR22","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1017\/cjn.2016.415","volume":"44","author":"SM Farhan","year":"2017","unstructured":"Farhan SM, Bartha R, Black SE, et al. The Ontario Neurodegenerative Disease Research Initiative (ONDRI). Can J Neurol Sci. 2017;44:196\u2013202. https:\/\/doi.org\/10.1017\/cjn.2016.415.","journal-title":"Can J Neurol Sci"},{"key":"1727_CR23","doi-asserted-by":"publisher","first-page":"847","DOI":"10.3389\/fneur.2020.00847","volume":"11","author":"J Ramirez","year":"2020","unstructured":"Ramirez J, Holmes MF, Scott CJM, et al. Ontario Neurodegenerative Disease Research Initiative (ONDRI): Structural MRI Methods and Outcome Measures. Front Neurol. 2020;11:847. https:\/\/doi.org\/10.3389\/fneur.2020.00847.","journal-title":"Front Neurol"},{"issue":"10","key":"1727_CR24","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1001\/jamaneurol.2017.1658","volume":"74","author":"RF Gottesman","year":"2017","unstructured":"Gottesman RF, Albert MS, Alonso A, Coker LH, Coresh J, Davis SM, Deal JA, McKhann GM, Mosley TH, Sharrett AR, Schneider ALC, Windham BG, Wruck LM, Knopman DS. Associations Between Midlife Vascular Risk Factors and 25-Year Incident Dementia in the Atherosclerosis Risk in Communities (ARIC) Cohort. JAMA Neurol. 2017;74(10):1246\u201354. https:\/\/doi.org\/10.1001\/jamaneurol.2017.1658.","journal-title":"JAMA Neurol"},{"issue":"10","key":"1727_CR25","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1002\/mds.26698","volume":"31","author":"N Malek","year":"2016","unstructured":"Malek N, Lawton MA, Swallow DM, Grosset KA, Marrinan SL, Bajaj N, Barker RA, Burn DJ, Hardy J, Morris HR, Williams NM, Wood N, Ben-Shlomo Y, Grosset DG, PRoBaND Clinical Consortium. Vascular disease and vascular risk factors in relation to motor features and cognition in early Parkinson's disease. Mov Disord. 2016;31(10):1518\u201326. https:\/\/doi.org\/10.1002\/mds.26698.","journal-title":"Mov Disord"},{"key":"1727_CR26","doi-asserted-by":"publisher","first-page":"707","DOI":"10.3233\/JAD-170149","volume":"59","author":"M Montero-Odasso","year":"2017","unstructured":"Montero-Odasso M, Pieruccini-Faria F, Bartha R, et al. Motor Phenotype in Neurodegenerative Disorders: Gait and Balance Platform Study Design Protocol for the Ontario Neurodegenerative Research Initiative (ONDRI). J Alzheimers Dis. 2017;59:707\u201321. https:\/\/doi.org\/10.3233\/JAD-170149.","journal-title":"J Alzheimers Dis"},{"key":"1727_CR27","volume-title":"Discovering Statistics using IBM SPSS Statistics","author":"A Field","year":"2024","unstructured":"Field A. Discovering Statistics using IBM SPSS Statistics. 6th ed. Sage Publications Ltd.; 2024.","edition":"6"},{"issue":"4","key":"1727_CR28","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1197\/j.aem.2004.11.018","volume":"12","author":"JS Haukoos","year":"2005","unstructured":"Haukoos JS, Lewis RJ. Advanced statistics: bootstrapping confidence intervals for statistics with \"difficult\" distributions. Acad Emerg Med. 2005;12(4):360\u20135. https:\/\/doi.org\/10.1197\/j.aem.2004.11.018.","journal-title":"Acad Emerg Med"},{"key":"1727_CR29","doi-asserted-by":"publisher","first-page":"863","DOI":"10.3389\/fpsyg.2013.00863","volume":"4","author":"D Lakens","year":"2013","unstructured":"Lakens D. Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs. Front Psychol. 2013;4:863. https:\/\/doi.org\/10.3389\/fpsyg.2013.00863.","journal-title":"Front Psychol"},{"issue":"4","key":"1727_CR30","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1002\/mdc3.12632","volume":"5","author":"\u00c1 S\u00e1nchez-Ferro","year":"2018","unstructured":"S\u00e1nchez-Ferro \u00c1, Matarazzo M, Mart\u00ednez-Mart\u00edn P, et al. Minimal Clinically Important Difference for UPDRS-III in Daily Practice. Mov Disord Clin Pract. 2018;5(4):448\u201350.","journal-title":"Mov Disord Clin Pract"},{"key":"1727_CR31","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1002\/mdc3.12632","volume":"18","author":"P Brown","year":"2003","unstructured":"Brown P. Oscillatory nature of human basal ganglia activity: relationship to the pathophysiology of Parkinson\u2019s disease. Mov Disord. 2003;18:357\u201363. https:\/\/doi.org\/10.1002\/mdc3.12632.","journal-title":"Mov Disord"},{"issue":"10291","key":"1727_CR32","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.1016\/S0140-6736(21)00218-X","volume":"397","author":"BR Bloem","year":"2021","unstructured":"Bloem BR, Okun MS, Klein C. Parkinson's disease. Lancet. 2021;397(10291):2284\u2013303. https:\/\/doi.org\/10.1016\/S0140-6736(21)00218-X.","journal-title":"Lancet"},{"issue":"3","key":"1727_CR33","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1093\/brain\/awz344","volume":"143","author":"M Bologna","year":"2020","unstructured":"Bologna M, Paparella G, Fasano A, Hallett M, Berardelli A. Evolving concepts on bradykinesia. Brain. 2020;143(3):727\u201350. https:\/\/doi.org\/10.1093\/brain\/awz344.","journal-title":"Brain"},{"issue":"3","key":"1727_CR34","doi-asserted-by":"publisher","first-page":"200","DOI":"10.3934\/Neuroscience.2023017","volume":"10","author":"S Ramesh","year":"2023","unstructured":"Ramesh S, Arachchige ASPM. Depletion of dopamine in Parkinson's disease and relevant therapeutic options: A review of the literature. AIMS Neurosci. 2023;10(3):200\u201331. https:\/\/doi.org\/10.3934\/Neuroscience.2023017.","journal-title":"AIMS Neurosci"},{"issue":"7","key":"1727_CR35","doi-asserted-by":"publisher","first-page":"596","DOI":"10.2174\/1871527320666211006142100","volume":"21","author":"S Kumar","year":"2022","unstructured":"Kumar S, Goyal L, Singh S. Tremor and Rigidity in Patients with Parkinson's Disease: Emphasis on Epidemiology, Pathophysiology and Contributing Factors. CNS Neurol Disord Drug Targets. 2022;21(7):596\u2013609. https:\/\/doi.org\/10.2174\/1871527320666211006142100.","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"1727_CR36","doi-asserted-by":"publisher","first-page":"568703","DOI":"10.3389\/fnhum.2020.568703","volume":"14","author":"DD Wang","year":"2020","unstructured":"Wang DD, Choi JT. Brain Network Oscillations During Gait in Parkinson's Disease. Front Hum Neurosci. 2020;14:568703. https:\/\/doi.org\/10.3389\/fnhum.2020.568703.","journal-title":"Front Hum Neurosci"},{"key":"1727_CR37","doi-asserted-by":"publisher","first-page":"120196","DOI":"10.1016\/j.jns.2022.120196","volume":"435","author":"MF Dirkx","year":"2022","unstructured":"Dirkx MF, Bologna M. The pathophysiology of Parkinson's disease tremor. J Neurol Sci. 2022;435:120196. https:\/\/doi.org\/10.1016\/j.jns.2022.120196.","journal-title":"J Neurol Sci"},{"issue":"6","key":"1727_CR38","doi-asserted-by":"publisher","first-page":"2208","DOI":"10.1093\/brain\/awad154","volume":"146","author":"K Younes","year":"2023","unstructured":"Younes K, Mormino EC. The pathotome and precision health. Brain. 2023;146(6):2208\u201310. https:\/\/doi.org\/10.1093\/brain\/awad154.","journal-title":"Brain"}],"container-title":["GeroScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11357-025-01727-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11357-025-01727-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11357-025-01727-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T09:24:26Z","timestamp":1773048266000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11357-025-01727-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,7]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["1727"],"URL":"https:\/\/doi.org\/10.1007\/s11357-025-01727-1","relation":{},"ISSN":["2509-2723"],"issn-type":[{"value":"2509-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,7]]},"assertion":[{"value":"14 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Research Ethics Board of Sunnybrook Health Sciences Centre (Project identification number: 013-2014). All participants gave written informed consent to participate.We confirm that we have read the Journal\u2019s position on issues involved in ethical publication and affirm that this work is consistent with those guidelines.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical compliance statement"}},{"value":"Informed consent for publication of data was obtained from all participants.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"AEL has served as an advisor for AbbVie, Amylyx, Aprinoia, Biogen, BioAdvance, Biohaven, BioVie, BlueRock, BMS, Denali, Janssen, Lilly, Pharma 2B, Sun Pharma, and UCB; received honoraria from Sun Pharma, AbbVie and Sunovion; received grants from Brain Canada, Canadian Institutes of Health Research, Edmond J Safra Philanthropic Foundation, Michael J. Fox Foundation, the Ontario Brain Institute, Parkinson Foundation, Parkinson Canada, and W. Garfield Weston Foundation; is serving as an expert witness in litigation related to paraquat and Parkinson\u2019s disease, received publishing royalties from Elsevier, Saunders, Wiley-Blackwell, Johns Hopkins Press, and Cambridge University Press.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}