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Despite its importance, comprehensive reviews on this topic remain limited. This study investigates the association between overweight\/obesity and oral health outcomes in adults aged 55 and older. This systematic review followed PRISMA guidelines and was registered with PROSPERO (CRD42020202108). A systematic literature search was conducted across PubMed, Embase.com, CINAHL, and Web of Science up to November 6, 2023. The study was structured using the Population, Intervention\/Exposure, Comparison, Outcome, and Study Design (PICOS) criteria: Population (P) included adults aged\u2009\u2265\u200955\u00a0years; Intervention\/Exposure (I\/E) involved overweight\/obesity; Comparison (C) included normal-weight individuals; Outcomes (O) focused on periodontal diseases, dental caries, tooth wear, and orofacial pain; and Study design (S) included case\u2013control, cross-sectional, prospective, and retrospective cohort studies and randomized controlled trials. Eligible studies underwent data extraction and quality assessment using the Newcastle\u2013Ottawa scale. Meta-analyses were conducted using fixed and random effects models in Stata v.18. From 6219 records, 16 studies met the inclusion criteria. Among these, 14 focused on periodontal diseases, while 2 examined dental caries. No studies met the eligibility criteria for tooth wear or orofacial pain. The included studies were predominantly of \u201cgood\u201d or \u201cvery good\u201d quality. Meta-analysis indicated that overweight or obese older adults had a significantly higher risk of periodontal disease compared with normal-weight counterparts (pooled odds ratio [OR]\u2009=\u20091.49; 95% confidence interval [CI] 1.13\u20131.97). The association was stronger in studies conducted in Asia (OR\u2009=\u20092.21; 95% CI 1.28\u20133.81) and in mixed-sex populations (OR\u2009=\u20091.52; 95% CI 1.02\u20132.28) compared with male-only samples. The two cross-sectional studies on dental caries yielded inconsistent findings, precluding a meta-analysis for this outcome. This systematic review demonstrates a significant association between overweight\/obesity and increased prevalence of periodontal disease in adults aged 55 and older. These findings underscore the need to consider oral health as a key component of general health in this population. The current evidence base is insufficient regarding dental caries, tooth wear, and orofacial pain, highlighting the need for high-quality research in these domains.<\/jats:p>","DOI":"10.1007\/s11357-025-01849-6","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T02:48:10Z","timestamp":1757299690000},"page":"4957-4979","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association between overweight\/obesity and oral health in adults aged 55 and older: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2628-2136","authenticated-orcid":false,"given":"Maryam","family":"Raoof","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"al Chafi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid Reza","family":"Tohidinik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"de Vries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Lobbezoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,8]]},"reference":[{"key":"1849_CR1","doi-asserted-by":"publisher","first-page":"9716","DOI":"10.1038\/s41598-022-13733-w","volume":"12","author":"M Alshakhs","year":"2022","unstructured":"Alshakhs M, Jackson B, Ikponmwosa D, Reynolds R, Madlock-Brown C. 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