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Epidemiological data on patients with AF who fall are limited. From the prospective global GLORIA-AF Registry Phase III study, we evaluated patients with a recent diagnosis of AF and CHA\n                    <jats:sub>2<\/jats:sub>\n                    DS\n                    <jats:sub>2<\/jats:sub>\n                    -VASc score\u2009\u2265\u20091 according to previous history of falling at baseline. We analyzed the associations with use of oral anticoagulant (OAC) and other drugs, risk of OAC discontinuation, and risk of major outcomes using multivariable regression models. Primary outcome was a composite of all-cause death and major adverse cardiovascular events (MACE); exploratory secondary outcomes were also analyzed. 20,875 patients (age 70.1\u2009\u00b1\u200910.3 years, 45.0% females) were included: 874 (4.2%) had prior falls. Patients with falls had more complex clinical profiles, were older, and were more likely female. No difference in OAC use was observed at baseline based on prior falls (OR [95%CI] 0.90 [0.75\u20131.08]), but patients with previous falls who received OAC were more likely treated with a NOAC compared to VKA (OR [95%CI] 1.29: 1.07\u20131.55) and were more likely to discontinue OAC during follow-up (HR 1.18, 95%CI 1.02\u20131.36). Patients with prior falls had a higher risk of the primary composite outcome (HR 1.63, 95%CI 1.40\u20131.90) and all secondary outcomes explored, including thromboembolism and major bleeding. Patients in the GLORIA-AF Registry with prior falls were more likely to receive a NOAC (vs. VKA) and had a higher risk of major adverse events, including all-cause mortality, thromboembolism, and major bleeding.\n                  <\/jats:p>","DOI":"10.1007\/s11357-025-01852-x","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T03:59:15Z","timestamp":1756353555000},"page":"3045-3058","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["History of falls in patients with atrial fibrillation and risk of major outcomes: analysis from the Prospective GLORIA-AF Registry"],"prefix":"10.1007","volume":"48","author":[{"given":"Giulio Francesco","family":"Romiti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadette","family":"Corica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Bucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Boriani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Olshansky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tze-Fan","family":"Chao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menno V.","family":"Huisman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Proietti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7566-1626","authenticated-orcid":false,"given":"Gregory Y. 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The study was conducted according to the Declaration of Helsinki and the Good Clinical Practice.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"GFR reports consultancy for Boehringer Ingelheim and an educational grant from Anthos, outside the submitted work. No fees are directly received personally. GB reports small speaker fees from Bayer, Boehringer Ingelheim, Boston, BMS, Daiichi, Sanofi, and Janssen, outside the submitted work. TFC reported honoraria for lectures from Boehringer Ingelheim, Bayer, Pfizer, and Daiichi Sankyo, outside the submitted work. BO has one disclosure AstraZeneca DSMB, Consultant for Boehringer Ingelheim. MVH has been receiving research grants from the Dutch Healthcare Fund, Dutch Heart Foundation, BMS-Pfizer, Bayer Healthcare, and Boehringer Ingelheim and consulting fees from BMS-Pfizer, Bayer Healthcare, and Boehringer Ingelheim to the institution. All other authors have nothing to declare. MP is the national leader of the AFFIRMO project on multimorbidity in atrial fibrillation, which has received funding from the European Union\u2019s Horizon 2020 research and innovation program under grant agreement no. 899871. GYHL has been a consultant and speaker for BMS\/Pfizer, Boehringer Ingelheim, Anthos, and Daiichi-Sankyo. No fees are directly received personally. All the disclosures happened outside the submitted work. GYHL is a National Institute for Health and Care Research (NIHR) Senior Investigator and co-principal investigator of the AFFIRMO project on multimorbidity in AF, which has received funding from the European Union\u2019s Horizon 2020 research and innovation program under grant agreement no. 899871.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}