{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:49:49Z","timestamp":1791618589859,"version":"4.3.4"},"reference-count":142,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"NUS Bia-Echo Asia Centre for Reproductive Longevity and Equality"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["GeroScience"],"DOI":"10.1007\/s11357-025-01876-3","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T22:08:35Z","timestamp":1757542115000},"page":"4981-4996","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Slowing down the clock on ovarian aging\u2014does the ovary hold the secret to the fountain of youth?"],"prefix":"10.1007","volume":"48","author":[{"given":"Paula","family":"Benny","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Chavarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4061-9321","authenticated-orcid":false,"given":"Zhongwei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,10]]},"reference":[{"key":"1876_CR1","unstructured":"World Health Organization. Ageing and health fact sheet. 2022.\u00a0https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/ageing-and-health."},{"key":"1876_CR2","unstructured":"Khalik S. Singaporeans have world\u2019s longest life expectancy at 84.8 years. 2019.\u00a0https:\/\/www.straitstimes.com\/singapore\/health\/singapore-tops-in-life-expectancy-at-848-years."},{"issue":"10","key":"1876_CR3","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1097\/GME.0000000000001424","volume":"26","author":"SR El Khoudary","year":"2019","unstructured":"El Khoudary SR, Greendale G, Crawford SL, Avis NE, Brooks MM, Thurston RC, et al. The menopause transition and women\u2019s health at midlife: a progress report from the study of women\u2019s health across the nation (SWAN). Menopause. 2019;26(10):1213.","journal-title":"Menopause"},{"issue":"10","key":"1876_CR4","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1093\/eurheartj\/ehaa1044","volume":"42","author":"AHEM Maas","year":"2021","unstructured":"Maas AHEM, Rosano G, Cifkova R, Chieffo A, van Dijken D, Hamoda H, et al. Cardiovascular health after menopause transition, pregnancy disorders, and other gynaecologic conditions: a consensus document from European cardiologists, gynaecologists, and endocrinologists. Eur Heart J. 2021;42(10):967.","journal-title":"Eur Heart J"},{"issue":"4","key":"1876_CR5","doi-asserted-by":"publisher","first-page":"2623","DOI":"10.1152\/physrev.00032.2022","volume":"103","author":"EE Telfer","year":"2023","unstructured":"Telfer EE, Grosbois J, Odey YL, Rosario RAR. Making a good egg: human oocyte health, aging, and in vitro development. Physiol Rev. 2023;103(4):2623.","journal-title":"Physiol Rev"},{"issue":"2","key":"1876_CR6","doi-asserted-by":"publisher","first-page":"661","DOI":"10.3390\/ijerph18020661","volume":"18","author":"F Baum","year":"2021","unstructured":"Baum F, Musolino C, Gesesew HAPJ. New perspective on why women live longer than men: an exploration of power, gender, social determinants, and capitals. Int J Environ Res Public Health. 2021;18(2):661.","journal-title":"Int J Environ Res Public Health"},{"key":"1876_CR7","doi-asserted-by":"publisher","first-page":"q999","DOI":"10.1136\/bmj.q999","volume":"385","author":"L Taylor","year":"2024","unstructured":"Taylor L. Women live longer than men but have more illness throughout life, global study finds. BMJ. 2024;385:q999.","journal-title":"BMJ"},{"key":"1876_CR8","unstructured":"US Centers for Disease Control and Prevention. National center for health statistics. 2024.\u00a0https:\/\/www.cdc.gov\/nchs\/index.html."},{"key":"1876_CR9","unstructured":"Singapore statistics. Department of Statistics Singapore. 2024. https:\/\/www.singstat.gov.sg\/"},{"key":"1876_CR10","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1146\/annurev.publhealth.23.100901.140513","volume":"23","author":"MR Gold","year":"2002","unstructured":"Gold MR, Stevenson DFD. HALYS and QALYS and DALYS, oh my: similarities and differences in summary measures of population health. Annu Rev Public Health. 2002;23:115.","journal-title":"Annu Rev Public Health"},{"issue":"10","key":"1876_CR11","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1093\/molehr\/gaq031","volume":"16","author":"ZWD Huang","year":"2010","unstructured":"Huang ZWD. The human oocyte and cumulus cells relationship: new insights from the cumulus cell transcriptome. Mol Hum Reprod. 2010;16(10):715.","journal-title":"Mol Hum Reprod"},{"key":"1876_CR12","doi-asserted-by":"crossref","unstructured":"Panay N, Anderson RA, Bennie A, Cedars M, Davies M, Ee C, Gravholt CH, Kalantaridou S, Kallen A, Kim KQ, Misrahi M, Mousa A, Nappi RE, Rocca WA, Ruan X, Teede H, Vermeulen N, Vogt E, Vincent AJ; ESHRE, ASRM, CREWHIRL and IGG on P. Evidence-based guideline: premature ovarian insufficiency. Hum Reprod Open. 2024;2024(4):hoae065.","DOI":"10.1093\/hropen\/hoae065"},{"issue":"163","key":"1876_CR13","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.maturitas.2022.06.002","volume":"9","author":"JE Bl\u00fcmel","year":"2022","unstructured":"Bl\u00fcmel JE, Mezones-Holgu\u00edn E, Chedraui P, Soto-Becerra P, Arteaga EVM. Is premature ovarian insufficiency associated with mortality? A three-decade follow-up cohort. Maturitas. 2022;9(163):82.","journal-title":"Maturitas"},{"issue":"8","key":"1876_CR14","doi-asserted-by":"publisher","first-page":"26929","DOI":"10.3402\/gha.v8.26929","volume":"27","author":"Y Song","year":"2015","unstructured":"Song Y, Ma J, Agardh A, Lau PW, Hu PZB. Secular trends in age at menarche among Chinese girls from 24 ethnic minorities, 1985 to 2010. Glob Health Action. 2015;27(8):26929.","journal-title":"Glob Health Action"},{"issue":"1","key":"1876_CR15","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/s12978-016-0240-y","volume":"13","author":"MH Lee","year":"2016","unstructured":"Lee MH, Kim SH, Oh M, Lee KW, PM. Age at menarche in Korean adolescents: trends and influencing factors. Reprod Health. 2016;13(1):121.","journal-title":"Reprod Health"},{"issue":"2","key":"1876_CR16","doi-asserted-by":"publisher","first-page":"e20170085","DOI":"10.1542\/peds.2017-0085","volume":"140","author":"X Meng","year":"2017","unstructured":"Meng X, Li S, Duan W, Sun Y, JC. Secular trend of age at menarche in Chinese adolescents born from 1973 to 2004. Pediatrics. 2017;140(2):e20170085.","journal-title":"Pediatrics"},{"key":"1876_CR17","unstructured":"TYE EA and CY. Age of menarche of a group of singapore girls. Hum Biol. 1970;42(2):329\u201336."},{"key":"1876_CR18","doi-asserted-by":"crossref","unstructured":"Balaji Ramraj, V. Meenakshi Subramanian VG. Study on age of menarche between generations and the factors associated with it. Clin Epidemiol Glob Heal. 2021;11:100758.","DOI":"10.1016\/j.cegh.2021.100758"},{"issue":"5","key":"1876_CR19","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1093\/humrep\/deh870","volume":"20","author":"C Gnoth","year":"2005","unstructured":"Gnoth C, Godehardt E, Frank-Herrmann P, Friol K, Tigges J, FG. Definition and prevalence of subfertility and infertility. Hum Reprod. 2005;20(5):1144.","journal-title":"Hum Reprod"},{"key":"1876_CR20","unstructured":"JW. W. Fecundity and natural fertility in humans. Oxf Rev Reprod Biol. 1989;11:61."},{"key":"1876_CR21","doi-asserted-by":"publisher","first-page":"114153","DOI":"10.1016\/j.socscimed.2021.114153","volume":"282","author":"A Carson","year":"2021","unstructured":"Carson A, Webster FJP, Bamford S. The power of potential: assisted reproduction and the counterstories of women who discontinue fertility treatment. Soc Sci Med. 2021;282:114153.","journal-title":"Soc Sci Med"},{"issue":"9","key":"1876_CR22","first-page":"e46921","volume":"15","author":"S Zabak","year":"2023","unstructured":"Zabak S, Varma A, Bansod SPM. Exploring the complex landscape of delayed childbearing: factors, history, and long-term implications. Cureus. 2023;15(9):e46921.","journal-title":"Cureus"},{"key":"1876_CR23","doi-asserted-by":"crossref","unstructured":"Medicine TPC of the AS for R. Aging and infertility in women. Fertil Steril. 2006;86(5):S248.","DOI":"10.1016\/j.fertnstert.2006.08.024"},{"issue":"10","key":"1876_CR24","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1093\/humrep\/deaa188","volume":"35","author":"M Christensen","year":"2020","unstructured":"Christensen M, Kesmodel U, Christensen K, Kirkegaard KIH. Early ovarian ageing: is a low number of oocytes harvested in young women associated with an earlier and increased risk of age-related diseases? Hum Reprod. 2020;35(10):2375\u201390.","journal-title":"Hum Reprod"},{"issue":"1","key":"1876_CR25","first-page":"1","volume":"7","author":"R Sj","year":"1993","unstructured":"Sj R. The biological basis of the menopause. Baillieres Clin Endocrinol Metab. 1993;7(1):1\u201316.","journal-title":"Baillieres Clin Endocrinol Metab"},{"issue":"3\u20134","key":"1876_CR26","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.maturitas.2004.11.004","volume":"52","author":"FH Loh","year":"2005","unstructured":"Loh FH, Khin LW, Saw SM, Lee JJGK. The age of menopause and the menopause transition in a multiracial population: a nation-wide Singapore study. Maturitas. 2005;52(3\u20134):169\u201380.","journal-title":"Maturitas"},{"issue":"7","key":"1876_CR27","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1093\/gerona\/glp055","volume":"64","author":"KR Smith","year":"2009","unstructured":"Smith KR, Gagnon A, Cawthon RM, Mineau GP, Mazan RDB. Familial aggregation of survival and late female reproduction. J Gerontol A Biol Sci Med Sci. 2009;64(7):740\u20134.","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"4","key":"1876_CR28","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1172\/JCI41350","volume":"120","author":"JSPS Richards","year":"2010","unstructured":"Richards JSPS. The ovary: basic biology and clinical implications. J Clin Invest. 2010;120(4):96.","journal-title":"J Clin Invest"},{"issue":"12","key":"1876_CR29","doi-asserted-by":"publisher","first-page":"800739","DOI":"10.3389\/fphys.2021.800739","volume":"27","author":"HCWD Alberico","year":"2022","unstructured":"Alberico HCWD. Role of granulosa cells in the aging ovarian landscape: a focus on mitochondrial and metabolic function. Front Physiol. 2022;27(12):800739.","journal-title":"Front Physiol"},{"key":"1876_CR30","doi-asserted-by":"publisher","first-page":"2292","DOI":"10.3390\/cells10092292","volume":"10","author":"B Turathum","year":"2021","unstructured":"Turathum B, Gao E-M, Chian R-C. The function of cumulus cells in oocyte growth and maturation and in subsequent ovulation and fertilization. Cells. 2021;10:2292.","journal-title":"Cells"},{"issue":"2","key":"1876_CR31","first-page":"200","volume":"21","author":"EAHA McGee","year":"2000","unstructured":"McGee EAHA. Initial and cyclic recruitment of ovarian follicles. Endocr Rev. 2000;21(2):200.","journal-title":"Endocr Rev"},{"issue":"2","key":"1876_CR32","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.ajog.2017.02.027","volume":"217","author":"RSD Tal","year":"2017","unstructured":"Tal RSD. Ovarian reserve testing: a user\u2019s guide. Am J Obs Gynecol. 2017;217(2):129.","journal-title":"Am J Obs Gynecol"},{"issue":"4","key":"1876_CR33","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1042\/BST20170493","volume":"46","author":"JRJK Sanders","year":"2018","unstructured":"Sanders JRJK. Regulation of the meiotic divisions of mammalian oocytes and eggs. Biochem Soc Trans. 2018;46(4):797.","journal-title":"Biochem Soc Trans"},{"key":"1876_CR34","unstructured":"Reed BG, Carr BR. The normal menstrual cycle and the control of ovulation. In: Feingold KR, Ahmed SF, Anawalt B, Blackman MR, Boyce A, Chrousos G, Corpas E, de Herder WW, Dhatariya K, Dungan K, Hofland J, Kalra S, Kaltsas G, Kapoor N, Koch C, Kopp P, Korbonits M, Kovacs CS, Kuohung W, Laferr\u00e8re B, Levy M, McGee EA, McLachlan R, Muzumdar R, Purnell J, Rey R, Sahay R, Shah AS, Singer F, Sperling MA, Stratakis CA, Trence DL, Wilson DP, editors.\u00a0Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000."},{"issue":"3","key":"1876_CR35","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.mcna.2015.01.006","volume":"99","author":"TAJK Takahashi","year":"2015","unstructured":"Takahashi TAJK. Menopause. Med Clin North Am. 2015;99(3):521\u201334.","journal-title":"Med Clin North Am"},{"issue":"1","key":"1876_CR36","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1186\/s12974-020-01998-9","volume":"17","author":"MRA McCarthy","year":"2020","unstructured":"McCarthy MRA. The peri-menopause in a woman\u2019s life: a systemic inflammatory phase that enables later neurodegenerative disease. J Neuroinflammation. 2020;17(1):317.","journal-title":"J Neuroinflammation"},{"key":"1876_CR37","doi-asserted-by":"crossref","unstructured":"Cunningham AC, Hewings-Martin Y, Wickham AP, Prentice C, Payne JL, Zhaunova L. Perimenopause symptoms, severity, and healthcare seeking in women in the US. npj Womens Heal. 2025;3(12).","DOI":"10.1038\/s44294-025-00061-3"},{"key":"1876_CR38","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1080\/09513590.2020.1852544","volume":"37","author":"L Tro\u00eca","year":"2020","unstructured":"Tro\u00eca L, Martone S, Morgante G, Luisi S. Management of perimenopause disorders: hormonal treatment. Gynecol Endocrinol. 2020;37:195\u2013200.","journal-title":"Gynecol Endocrinol"},{"issue":"6","key":"1876_CR39","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1210\/endrev\/bnab015","volume":"42","author":"EG Mills","year":"2021","unstructured":"Mills EG, Yang L, Nielsen MF, Kassem M, Dhillo WS, ANC. The relationship between bone and reproductive hormones beyond estrogens and androgens. Endocr Rev. 2021;42(6):691.","journal-title":"Endocr Rev"},{"key":"1876_CR40","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.bone.2019.03.033","volume":"123","author":"BC Collins","year":"2019","unstructured":"Collins BC, Laakkonen EKLD. Aging of the musculoskeletal system: how the loss of estrogen impacts muscle strength. Bone. 2019;123:137.","journal-title":"Bone"},{"issue":"12","key":"1876_CR41","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1038\/s43587-024-00767-0","volume":"4","author":"C Camon","year":"2024","unstructured":"Camon C, Garratt MCS. Exploring the effects of estrogen deficiency and aging on organismal homeostasis during menopause. Nat Aging. 2024;4(12):1731.","journal-title":"Nat Aging"},{"key":"1876_CR42","doi-asserted-by":"crossref","unstructured":"Z\u00e1rate S ST and GR. Role of estrogen and other sex hormones in brain aging. neuroprotection and DNA repair. Front Aging Neurosci. 2017;9:430.","DOI":"10.3389\/fnagi.2017.00430"},{"issue":"9","key":"1876_CR43","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1093\/gerona\/glaa204","volume":"76","author":"NHC Llarena","year":"2021","unstructured":"Llarena NHC. Reproductive longevity and aging: geroscience approaches to maintain long-term ovarian fitness. J Gerontol A Biol Sci Med Sci. 2021;76(9):1551\u201360.","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"1876_CR44","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/s43587-024-00762-5","volume":"5","author":"C Jin","year":"2025","unstructured":"Jin C, Wang X, Yang J, et al. Molecular and genetic insights into human ovarian aging from single-nuclei multi-omics analyses. Nat Aging. 2025;5:275.","journal-title":"Nat Aging"},{"issue":"8","key":"1876_CR45","doi-asserted-by":"publisher","first-page":"575706","DOI":"10.3389\/fcell.2020.575706","volume":"30","author":"Y Chen","year":"2020","unstructured":"Chen Y, Yang W, Shi X, Zhang C, Song GHD. No title the factors and pathways regulating the activation of mammalian primordial follicles in vivo. Front Cell Dev Biol. 2020;30(8):575706.","journal-title":"Front Cell Dev Biol"},{"issue":"2","key":"1876_CR46","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.ydbio.2005.02.013","volume":"281","author":"P Reddy","year":"2005","unstructured":"Reddy P, Shen L, Ren C, Boman K, Lundin E, Ottander U, et al. Activation of Akt (PKB) and suppression of FKHRL1 in mouse and rat oocytes by stem cell factor during follicular activation and development. Dev Biol. 2005;281(2):160.","journal-title":"Dev Biol"},{"issue":"7872","key":"1876_CR47","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1038\/s41586-021-03779-7","volume":"596","author":"KS Ruth","year":"2021","unstructured":"Ruth KS, Day FR, Hussain J, Mart\u00ednez-Marchal A, Aiken CE, Azad A, et al. Genetic insights into biological mechanisms governing human ovarian ageing. Nature. 2021;596(7872):393\u20137.","journal-title":"Nature"},{"issue":"7119","key":"1876_CR48","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1038\/nature05337","volume":"444","author":"EK Suh","year":"2006","unstructured":"Suh EK, Yang A, Kettenbach A, Bamberger C, Michaelis AH, Zhu Z, et al. P63 protects the female germ line during meiotic arrest. Nature. 2006;444(7119):624.","journal-title":"Nature"},{"issue":"2","key":"1876_CR49","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1534\/genetics.120.303182","volume":"215","author":"VD Rinaldi","year":"2020","unstructured":"Rinaldi VD, Bloom JCSJ. Oocyte elimination through DNA damage signaling from CHK1\/CHK2 to p53 and p63. Genetics. 2020;215(2):373.","journal-title":"Genetics"},{"issue":"3","key":"1876_CR50","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1093\/ije\/dyac215","volume":"52","author":"J Lankester","year":"2023","unstructured":"Lankester J, Li J, Salfati ELI, Stefanick ML, Chan KHK, Liu S, et al. Genetic evidence for causal relationships between age at natural menopause and the risk of ageing-associated adverse health outcomes. Int J Epidemiol. 2023;52(3):806.","journal-title":"Int J Epidemiol"},{"issue":"1","key":"1876_CR51","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1097\/GME.0000000000000387","volume":"22","author":"AQ SL","year":"2015","unstructured":"AQ SL, C. What explains the link between reproductive events and women\u2019s longevity? Menopause. 2015;22(1):6\u20138.","journal-title":"Menopause"},{"issue":"1","key":"1876_CR52","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1093\/aje\/kws421","volume":"178","author":"EB Gold","year":"2013","unstructured":"Gold EB, Crawford SL, Avis NE, Crandall CJ, Matthews KA, Waetjen LE, et al. Factors related to age at natural menopause: longitudinal analyses from SWAN. Am J Epidemiol. 2013;178(1):70\u201383.","journal-title":"Am J Epidemiol"},{"issue":"11","key":"1876_CR53","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1097\/GME.0000000000001669","volume":"27","author":"CD Latour","year":"2020","unstructured":"Latour CD, O\u2019Connell K, Romano ME, Kantor EDDM. Maternal age at last birth and leukocyte telomere length in a nationally representative population of perimenopausal and postmenopausal women. Menopause. 2020;27(11):1242\u201350.","journal-title":"Menopause"},{"issue":"5","key":"1876_CR54","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1097\/GME.0000000000000795","volume":"24","author":"E Fagan","year":"2017","unstructured":"Fagan E, Sun F, Bae H, Elo I, Andersen SL, Lee J, et al. Telomere length is longer in women with late maternal age. Menopause. 2017;24(5):497\u2013501.","journal-title":"Menopause"},{"issue":"1","key":"1876_CR55","doi-asserted-by":"publisher","first-page":"113","DOI":"10.2105\/AJPH.2016.303503","volume":"107","author":"AH Shadyab","year":"2017","unstructured":"Shadyab AH, Gass ML, Stefanick ML, Waring ME, Macera CA, Gallo LC, et al. Maternal age at childbirth and parity as predictors of longevity among women in the United States: the Women\u2019s Health Initiative. Am J Public Health. 2017;107(1):113\u20139.","journal-title":"Am J Public Health"},{"key":"1876_CR56","doi-asserted-by":"publisher","unstructured":"Xing Z, Kirby RS, Chen H, Cain MA, Alman AC. Associations between parity, age at childbirth, and later-life mortality in postmenopausal women mediated by premature menopause. Am J Obstet Gynecol. 2025. https:\/\/doi.org\/10.1016\/j.ajog.2025.06.005","DOI":"10.1016\/j.ajog.2025.06.005"},{"key":"1876_CR57","doi-asserted-by":"crossref","unstructured":"Ahrenfeldt LJ, M\u00f6ller S, Wensink MJ, Eisenberg ML, Christensen K, Jensen TK L-JR. Impaired fecundity as a marker of health and survival: a Danish twin cohort study. Hum Reprod. 2021;36(8):2309\u201320.","DOI":"10.1093\/humrep\/deab077"},{"issue":"3","key":"1876_CR58","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.fertnstert.2022.05.038","volume":"118","author":"KH Sk\u00e5ra","year":"2022","unstructured":"Sk\u00e5ra KH, \u00c5svold BO, Hern\u00e1ez \u00c1, Fraser A, Rich-Edwards JW, Farland LV, et al. Risk of cardiovascular disease in women and men with subfertility: the Tr\u00f8ndelag Health Study. Fertil Steril. 2022;118(3):537\u201347.","journal-title":"Fertil Steril"},{"key":"1876_CR59","doi-asserted-by":"crossref","unstructured":"Latif T, Kold Jensen T, Mehlsen J, Holmboe SA, Brinth L, Pors K, Skouby SO, J\u00f8rgensen N L-JR. Semen quality as a predictor of subsequent morbidity: a Danish cohort study of 4,712 men with long-term follow-up. Am J Epidemiol. 2017;186(8):910\u20137.","DOI":"10.1093\/aje\/kwx067"},{"issue":"4","key":"1876_CR60","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1007\/s10815-016-0663-y","volume":"33","author":"S Gunes","year":"2016","unstructured":"Gunes S, Hekim GN, Arslan MAAR. Effects of aging on the male reproductive system. J Assist Reprod Genet. 2016;33(4):441.","journal-title":"J Assist Reprod Genet"},{"issue":"4","key":"1876_CR61","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1016\/j.fertnstert.2013.05.046","volume":"100","author":"BA Stone","year":"2013","unstructured":"Stone BA, Alex A, Werlin LB. Age thresholds for changes in semen parameters in men. Fertil Steril. 2013;100(4):952.","journal-title":"Fertil Steril"},{"key":"1876_CR62","doi-asserted-by":"crossref","unstructured":"Neaves WB, Johnson L, Porter JC, Parker CR Jr PC. Leydig cell numbers, daily sperm production, and serum gonadotropin levels in aging men. J Clin Endocrinol Metab. 1984;59(4):756.","DOI":"10.1210\/jcem-59-4-756"},{"issue":"1","key":"1876_CR63","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1530\/jrf.0.0700211","volume":"70","author":"L Johnson","year":"1984","unstructured":"Johnson L, Petty CSNW. Influence of age on sperm production and testicular weights in men. J Reprod Fertil. 1984;70(1):211.","journal-title":"J Reprod Fertil"},{"key":"1876_CR64","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/s41580-021-00411-4","volume":"23","author":"CL Green","year":"2022","unstructured":"Green CL, Lamming DW, Fontana L. Molecular mechanisms of dietary restriction promoting health and longevity. Nat Rev Mol Cell Biol. 2022;23:56.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"1876_CR65","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s40001-015-0114-8","volume":"20","author":"WJ Liu","year":"2015","unstructured":"Liu WJ, Zhang XM, Wang N, Zhou XL, Fu YC. Calorie restriction inhibits ovarian follicle development and follicle loss through activating SIRT1 signaling in mice. Eur J Med Res. 2015;20(1):22 LL.","journal-title":"Eur J Med Res"},{"issue":"5","key":"1876_CR66","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1111\/j.1474-9726.2008.00409.x","volume":"7","author":"K Selesniemi","year":"2008","unstructured":"Selesniemi K, Lee HJTJ. Moderate caloric restriction initiated in rodents during adulthood sustains function of the female reproductive axis into advanced chronological age. Aging Cell. 2008;7(5):622.","journal-title":"Aging Cell"},{"issue":"1","key":"1876_CR67","doi-asserted-by":"publisher","first-page":"100856","DOI":"10.1016\/j.repbio.2024.100856","volume":"24","author":"GB Veiga","year":"2024","unstructured":"Veiga GB, Zanini BM, Garcia DN, Hense JD, Barreto MM, Isola JVV, et al. Effects of calorie, protein, and branched chain amino acid restriction on ovarian aging in mice. Reprod Biol. 2024;24(1):100856.","journal-title":"Reprod Biol"},{"issue":"6","key":"1876_CR68","doi-asserted-by":"publisher","first-page":"e13626","DOI":"10.1111\/acel.13626","volume":"21","author":"ME Trautman","year":"2022","unstructured":"Trautman ME, Richardson NELD. Protein restriction and branched-chain amino acid restriction promote geroprotective shifts in metabolism. Aging Cell. 2022;21(6):e13626.","journal-title":"Aging Cell"},{"issue":"5","key":"1876_CR69","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1095\/biolreprod.115.137414","volume":"94","author":"ME Skaznik-Wikiel","year":"2016","unstructured":"Skaznik-Wikiel ME, Swindle DC, Allshouse AA, Polotsky AJMJ. High-fat diet causes subfertility and compromised ovarian function independent of obesity in mice. Biol Reprod. 2016;94(5):108.","journal-title":"Biol Reprod"},{"issue":"11","key":"1876_CR70","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1093\/molehr\/gaz049","volume":"25","author":"E Andreas","year":"2019","unstructured":"Andreas E, Reid M, Zhang WMK. The effect of maternal high-fat\/high-sugar diet on offspring oocytes and early embryo development. Mol Hum Reprod. 2019;25(11):717.","journal-title":"Mol Hum Reprod"},{"issue":"2","key":"1876_CR71","doi-asserted-by":"publisher","first-page":"3334","DOI":"10.3390\/nu12020334","volume":"12","author":"HCP Cena","year":"2020","unstructured":"Cena HCP. Defining a healthy diet: evidence for the role of contemporary dietary patterns in health and disease. Nutrients. 2020;12(2):3334.","journal-title":"Nutrients"},{"issue":"6","key":"1876_CR72","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.3945\/ajcn.2009.28415","volume":"91","author":"F Kolahdooz","year":"2010","unstructured":"Kolahdooz F, van der Pols JC, Bain CJ, Marks GC, Hughes MC, Whiteman DC, et al. Meat, fish, and ovarian cancer risk: results from 2 Australian case-control studies, a systematic review, and meta-analysis. Am J Clin Nutr. 2010;91(6):1752\u201363.","journal-title":"Am J Clin Nutr"},{"issue":"5","key":"1876_CR73","doi-asserted-by":"publisher","first-page":"e0251789","DOI":"10.1371\/journal.pone.0251789","volume":"16","author":"J Sadowska","year":"2021","unstructured":"Sadowska J, DI Dudzi\u0144ska W. Effects of different models of sucrose intake on the oxidative status of the uterus and ovary of rats. PLoS One. 2021;16(5):e0251789.","journal-title":"PLoS One"},{"issue":"6","key":"1876_CR74","doi-asserted-by":"publisher","first-page":"135","DOI":"10.3892\/etm.2020.9264","volume":"20","author":"S Yan","year":"2020","unstructured":"Yan S, Wang FSQ. The effect of maternal high-fat-diet mediated oxidative stress on ovarian function in mice offspring. Exp Ther Med. 2020;20(6):135.","journal-title":"Exp Ther Med"},{"issue":"1","key":"1876_CR75","first-page":"44","volume":"10","author":"D Kiranmayee","year":"2017","unstructured":"Kiranmayee D, Praveena T, Himabindu Y, Sriharibabu M, Kavya K, Mahalakshmi M. The effect of moderate physical activity on ovarian reserve markers in reproductive age women below and above 30 years. J Hum Reprod Sci. 2017;10(1):44\u20138.","journal-title":"J Hum Reprod Sci"},{"issue":"8","key":"1876_CR76","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1108\/00251740910984514","volume":"47","author":"AS Al-Eisa","year":"2009","unstructured":"Al-Eisa AS, Furayyan MAAA. An empirical examination of the effects of self-efficacy, supervisor support and motivation to learn on transfer intention. Manag Decis. 2009;47(8):1221\u201344.","journal-title":"Manag Decis"},{"issue":"3","key":"1876_CR77","first-page":"295","volume":"19","author":"M Tonekaboni","year":"2012","unstructured":"Tonekaboni M, Peeri MAM. Effect of two intensity of aerobic exercise on clinical symptoms of premenstrual syndrome in fertile women. World Appl Sci J. 2012;19(3):295\u2013301.","journal-title":"World Appl Sci J"},{"key":"1876_CR78","doi-asserted-by":"crossref","unstructured":"Bedrick BS, Broughton DE, Schulte M, Boots CE, Eskew AM JE. Physical activity is negatively associated with antral follicle count. Fertil Steril. 2017;107(E):22\u201333.","DOI":"10.1016\/j.fertnstert.2017.02.061"},{"key":"1876_CR79","doi-asserted-by":"crossref","unstructured":"Mussawar M, Balsom AA, Totosy de Zepetnek JO GJ. The effect of physical activity on fertility: a mini-review. F S Rep. 2023;4(2):150.","DOI":"10.1016\/j.xfre.2023.04.005"},{"key":"1876_CR80","doi-asserted-by":"publisher","first-page":"3837623","DOI":"10.1155\/2016\/3837623","volume":"2016","author":"S Falone","year":"2016","unstructured":"Falone S, Santini SJ, Cordone V, Grannonico M, Cacchio M, Di Emidio G, Tatone CAF. Regular and moderate exercise counteracts the decline of antioxidant protection but not methylglyoxal-dependent glycative burden in the ovary of reproductively aging mice. Oxid Med Cell Longev. 2016;2016:3837623.","journal-title":"Oxid Med Cell Longev"},{"issue":"16","key":"1876_CR81","first-page":"100","volume":"20","author":"G Beroukhim","year":"2022","unstructured":"Beroukhim G, Esencan E, Seifer DB. Impact of sleep patterns upon female neuroendocrinology and reproductive outcomes: a comprehensive review. Reprod Biol Endocrinol. 2022;20(16):100.","journal-title":"Reprod Biol Endocrinol"},{"issue":"18","key":"1876_CR82","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5334\/jcr.190","volume":"23","author":"OMAM Lateef","year":"2020","unstructured":"Lateef OMAM. Sleep and Reproductive Health. J Circadian Rhythm. 2020;23(18):1.","journal-title":"J Circadian Rhythm"},{"issue":"41","key":"1876_CR83","doi-asserted-by":"publisher","first-page":"e2402393","DOI":"10.1002\/advs.202402393","volume":"11","author":"L Weng","year":"2024","unstructured":"Weng L, Hong H, Zhang Q, Xiao C, Zhang Q, Wang Q, Huang JLD. Sleep deprivation triggers the excessive activation of ovarian primordial follicles via \u03b22 adrenergic receptor signaling. Adv Sci. 2024;11(41):e2402393.","journal-title":"Adv Sci"},{"issue":"10","key":"1876_CR84","doi-asserted-by":"publisher","first-page":"1029469","DOI":"10.3389\/fpubh.2022.1029469","volume":"3","author":"F Zhao","year":"2022","unstructured":"Zhao F, Hong X, Wang W, Wu JWB. Effects of physical activity and sleep duration on fertility: a systematic review and meta-analysis based on prospective cohort studies. Front Public Health. 2022;3(10):1029469.","journal-title":"Front Public Health"},{"issue":"10","key":"1876_CR85","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1093\/abm\/kaad015","volume":"57","author":"KM Harris","year":"2023","unstructured":"Harris KM, Gaffey AE, Schwartz JE, Krantz DS. The perceived stress scale as a measure of stress: decomposing score variance in longitudinal behavioral medicine studies. Ann Behav Med. 2023;57(10):846.","journal-title":"Ann Behav Med"},{"issue":"23","key":"1876_CR86","first-page":"26","volume":"29","author":"S Prasad","year":"2016","unstructured":"Prasad S, Tiwari M, Pandey AN, Shrivastav TGCS. Impact of stress on oocyte quality and reproductive outcome. J Biomed Sci. 2016;29(23):26.","journal-title":"J Biomed Sci"},{"key":"1876_CR87","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2015.09.010","author":"MNM Kala","year":"2016","unstructured":"Kala MNM. Role of cortisol and superoxide dismutase in psychological stress induced anovulation. Gen Comp Endocrinol. 2016. https:\/\/doi.org\/10.1016\/j.ygcen.2015.09.010.","journal-title":"Gen Comp Endocrinol"},{"issue":"4","key":"1876_CR88","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1095\/biolreprod.110.087890","volume":"84","author":"SY Zhang","year":"2011","unstructured":"Zhang SY, Wang JZ, Li JJ, Wei DL, Sui HS, Zhang ZH, et al. Maternal restraint stress diminishes the developmental potential of oocytes. Biol Reprod. 2011;84(4):672\u201381.","journal-title":"Biol Reprod"},{"issue":"3","key":"1876_CR89","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1097\/GCO.0b013e32832924ba","volume":"21","author":"EH Ruder","year":"2009","unstructured":"Ruder EH, Hartman TJGM. Impact of oxidative stress on female fertility. Curr Opin Obstet Gynecol. 2009;21(3):219\u201322.","journal-title":"Curr Opin Obstet Gynecol"},{"issue":"2","key":"1876_CR90","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.ejogrb.2010.12.006","volume":"155","author":"M Chelchowska","year":"2011","unstructured":"Chelchowska M, Ambroszkiewicz J, Gajewska J, Laskowska-Klita T. The effect of tobacco smoking during pregnancy on plasma oxidant and antioxidant status in mother and newborn. Eur J Obstet Gynecol Reprod Biol. 2011;155(2):132\u20136 LJ.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"9","key":"1876_CR91","doi-asserted-by":"publisher","first-page":"309","DOI":"10.3390\/biomedicines8090309","volume":"8","author":"F Konstantinidou","year":"2020","unstructured":"Konstantinidou F, Stuppia LGV. Looking inside the world of granulosa cells: the noxious effects of cigarette smoke. Biomedicines. 2020;8(9):309.","journal-title":"Biomedicines"},{"key":"1876_CR92","doi-asserted-by":"crossref","unstructured":"P K. Unifying mechanism for addiction and toxicity of abused drugs with application to dopamine and glutamate mediators: electron transfer and reactive oxygen species. Med Hypotheses. 2005;65(1):90\u20136.","DOI":"10.1016\/j.mehy.2005.01.031"},{"issue":"3","key":"1876_CR93","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/j.mayocp.2013.11.005","volume":"89","author":"JH O\u2019Keefe","year":"2014","unstructured":"O\u2019Keefe JH, Bhatti SK, Bajwa A, DiNicolantonio JJLC. Alcohol and cardiovascular health: the dose makes the poison\u2026or the remedy. Mayo Clin Proc. 2014;89(3):382.","journal-title":"Mayo Clin Proc"},{"issue":"1","key":"1876_CR94","doi-asserted-by":"publisher","first-page":"13815","DOI":"10.1038\/s41598-017-14261-8","volume":"7","author":"D Fan","year":"2017","unstructured":"Fan D, Liu LI, Xia Q, et al. Female alcohol consumption and fecund-ability: a systematic review and dose-response meta-analysis. Sci Rep. 2017;7(1):13815.","journal-title":"Sci Rep"},{"issue":"1","key":"1876_CR95","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1093\/humrep\/dev271","volume":"31","author":"JD Peck","year":"2016","unstructured":"Peck JD, Quaas AM, Craig LB, Soules MR, Klein NAHK. Lifestyle factors associated with histologically derived human ovar- ian non-growing follicle count in reproductive age women. Hum Reprod. 2016;31(1):150\u20137.","journal-title":"Hum Reprod"},{"issue":"1","key":"1876_CR96","doi-asserted-by":"publisher","first-page":"13815","DOI":"10.1038\/s41598-017-14261-8","volume":"7","author":"D Fan","year":"2017","unstructured":"Fan D, Liu L, Xia Q, Wang W, Wu S, Tian G, et al. Female alcohol consumption and fecundability: a systematic review and dose-response meta-analysis. Sci Rep. 2017;7(1):13815.","journal-title":"Sci Rep"},{"issue":"1","key":"1876_CR97","doi-asserted-by":"publisher","first-page":"e220254","DOI":"10.1530\/JOE-22-0254","volume":"257","author":"Y Kasahara","year":"2023","unstructured":"Kasahara Y, Kishi H, Yokomizo ROA. Ethanol potentiates follicle-stimulating hormone action in ovarian granulosa cells. J Endocrinol. 2023;257(1):e220254.","journal-title":"J Endocrinol"},{"issue":"3","key":"1876_CR98","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1210\/endo-113-3-949","volume":"113","author":"M Knecht","year":"1983","unstructured":"Knecht M, Ranta TCK. Granulosa cell differentiation in vitro: induction and maintenance of follicle-stimulating hormone receptors by adenosine 3\u2019,5\u2019-monophosphate. Endocrinology. 1983;113(3):949.","journal-title":"Endocrinology"},{"issue":"13","key":"1876_CR99","doi-asserted-by":"publisher","first-page":"13128","DOI":"10.18632\/aging.103401","volume":"12","author":"Y Diao","year":"2020","unstructured":"Diao Y, Nie J, Tan P, Zhao Y, Zhao T, Tu J, et al. Long-term low-dose ethanol intake improves healthspan and resists high-fat diet-induced obesity in mice. Aging (Albany NY). 2020;12(13):13128.","journal-title":"Aging (Albany NY)"},{"key":"1876_CR100","doi-asserted-by":"crossref","unstructured":"Stuart Adamson, Lear Brace BK. Alcohol and aging: from epidemiology to mechanism. Transl Med Aging. 2017;1:18.","DOI":"10.1016\/j.tma.2017.09.001"},{"key":"1876_CR101","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3109\/09513590.2011.589925","volume":"28","author":"AS Batioglu","year":"2012","unstructured":"Batioglu AS, Sahin U, Gurlek B, Ozturk N, Unsal E. The efficacy of melatonin administration on oocyte quality. Gynecol Endocrinol. 2012;28:91\u20133.","journal-title":"Gynecol Endocrinol"},{"key":"1876_CR102","doi-asserted-by":"publisher","first-page":"545","DOI":"10.3389\/fendo.2018.00545","volume":"9","author":"S Fernando","year":"2018","unstructured":"Fernando S, et al. Melatonin in assisted reproductive technology: a pilot double- blind randomized placebo-controlled clinical trial. Front Endocrinol. 2018;9:545.","journal-title":"Front Endocrinol"},{"key":"1876_CR103","doi-asserted-by":"publisher","first-page":"338","DOI":"10.3390\/antiox8090338","volume":"8","author":"J Espino","year":"2019","unstructured":"Espino J, et al. Impact of melatonin supplementation in women with unexplained infertility undergoing fertility treatment. Antioxidants. 2019;8:338.","journal-title":"Antioxidants"},{"key":"1876_CR104","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/S0531-5565(00)00217-5","volume":"36","author":"G Bellipanni","year":"2001","unstructured":"Bellipanni G, Bianchi P, Pierpaoli W, Bulian D. Effects of melatonin in perimenopausal and menopausal women: a randomized and placebo controlled study. Exp Gerontol. 2001;36:297\u2013310.","journal-title":"Exp Gerontol"},{"issue":"9","key":"1876_CR105","doi-asserted-by":"publisher","first-page":"2505","DOI":"10.1007\/s43032-021-00768-z","volume":"29","author":"RS Barberino","year":"2022","unstructured":"Barberino RS, Lins TLBG, Monte APO, Gouveia BB, Campinho DSP, Palheta RC Jr, et al. Melatonin attenuates cyclophosphamide-induced primordial follicle loss by interaction with MT1 receptor and modulation of PTEN\/Akt\/FOXO3a proteins in the mouse ovary. Reprod Sci. 2022;29(9):2505.","journal-title":"Reprod Sci"},{"issue":"13","key":"1876_CR106","doi-asserted-by":"publisher","first-page":"895095","DOI":"10.3389\/fendo.2022.895095","volume":"3","author":"J Feng","year":"2022","unstructured":"Feng J, Ma WW, Li HX, Pei XY, Deng SL, Jia HMW. Melatonin prevents cyclophosphamide-induced primordial follicle loss by inhibiting ovarian granulosa cell apoptosis and maintaining AMH expression. Front Endocrinol (Lausanne). 2022;3(13):895095.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"16","key":"1876_CR107","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.21037\/atm-21-3294","volume":"9","author":"J He","year":"2021","unstructured":"He J, Xu W, Zheng X, Zhao B, Ni T, Yu P, et al. Vitamin C reduces vanco- mycin-related nephrotoxicity through the inhibition of oxidative stress, apoptosis, and inflammation in mice. Ann Transl Med. 2021;9(16):1319.","journal-title":"Ann Transl Med"},{"issue":"4","key":"1876_CR108","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1002\/jbt.20030","volume":"18","author":"EA Hassoun","year":"2004","unstructured":"Hassoun EA, Vodhanel JAA. The modulatory effects of ellagic acid and vitamin E succinate on TCDD-induced oxidative stress in different brain regions of rats after subchronic exposure. J Biochem Mol Toxicol. 2004;18(4):196\u2013203.","journal-title":"J Biochem Mol Toxicol"},{"key":"1876_CR109","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.rvsc.2020.03.028","volume":"131","author":"MS Hossain","year":"2020","unstructured":"Hossain MS, Dutta RK, Muralidhar KGR. Decreased ascorbic acid biosynthesis in response to PMSG in the pre-pubertal female rat ovary. Res Vet Sci. 2020;131:15\u201320.","journal-title":"Res Vet Sci"},{"issue":"2","key":"1876_CR110","doi-asserted-by":"publisher","first-page":"196","DOI":"10.5115\/acb.2019.52.2.196","volume":"52","author":"MA Abdollahifar","year":"2019","unstructured":"Abdollahifar MA, Azad N, Sajadi E, Shams Mofarahe Z, Zare F, Moradi A, et al. Vitamin C restores ovarian follicular reservation in a mouse model of aging. Anat Cell Biol. 2019;52(2):196\u2013203.","journal-title":"Anat Cell Biol"},{"key":"1876_CR111","doi-asserted-by":"publisher","first-page":"102533","DOI":"10.1016\/j.ctim.2020.102533","volume":"56","author":"FD Safiyeh","year":"2021","unstructured":"Safiyeh FD, Mojgan M, Parviz S, Sakineh MABS. The effect of selenium and vitamin E supplementation on anti-Mullerian hormone and antral follicle count in infertile women with occult premature ovarian insufficiency: a randomized controlled clinical trial. Complement Ther Med. 2021;56:102533.","journal-title":"Complement Ther Med"},{"issue":"2","key":"1876_CR112","doi-asserted-by":"publisher","first-page":"79","DOI":"10.18502\/ijrm.v17i2.3985","volume":"17","author":"Z Sargazi","year":"2019","unstructured":"Sargazi Z, Reza Nikravesh M, Jalali M, Reza Sadeghnia HRA. The protective effect of vitamin E on rats\u2019 ovarian follicles following an administration of diazinon: an experimental study. Int J Reprod Biomed. 2019;17(2):79\u201388.","journal-title":"Int J Reprod Biomed"},{"issue":"2","key":"1876_CR113","first-page":"125","volume":"7","author":"M Molavi","year":"2016","unstructured":"Molavi M, Razi M, Cheraghi H, Khorramjouy M, Ostadi AGS. Protective effect of vitamin E on cypermethrin-induced follicular atresia in rat ovary: evidence for energy dependent mechanism. Vet Res Forum. 2016;7(2):125\u201332.","journal-title":"Vet Res Forum"},{"issue":"2","key":"1876_CR114","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1093\/humupd\/dmz046","volume":"26","author":"Y Zhang","year":"2020","unstructured":"Zhang Y, Zhang C, Shu J, Guo J, Chang HM, Leung PCK, et al. Adjuvant treatment strategies in ovarian stimulation for poor responders undergoing IVF: a systematic review and network meta-analysis. Hum Reprod Update. 2020;26(2):247\u201363.","journal-title":"Hum Reprod Update"},{"key":"1876_CR115","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.arr.2008.10.002","volume":"8","author":"YSZ Wang","year":"2009","unstructured":"Wang YSZ. Current understanding of klotho. Ageing Res Rev. 2009;8:43\u201351.","journal-title":"Ageing Res Rev"},{"key":"1876_CR116","doi-asserted-by":"crossref","unstructured":"Buchanan S, Combet E, Stenvinkel P, Shiels PG. Klotho, Aging, and the Failing Kidney. Front Endocrinol (Lausanne).\u00a02020;27(11):560.","DOI":"10.3389\/fendo.2020.00560"},{"issue":"4","key":"1876_CR117","first-page":"3511","volume":"16","author":"N Ji","year":"2018","unstructured":"Ji N, Luan J, Hu F, Zhao Y, Lv B, Wang W, Xia M, Zhao XLK. Aerobic exercise-stimulated Klotho upregulation extends life span by attenuating the excess production of reactive oxygen species in the brain and kidney. Exp Ther Med. 2018;16(4):3511\u20137.","journal-title":"Exp Ther Med"},{"issue":"6","key":"1876_CR118","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1016\/j.fertnstert.2020.06.035","volume":"114","author":"X Xu","year":"2020","unstructured":"Xu X, Hao Y, Zhong Q, Hang J, Zhao YQJ. Low KLOTHO level related to aging is associated with diminished ovarian reserve. Fertil Steril. 2020;114(6):1250.","journal-title":"Fertil Steril"},{"key":"1876_CR119","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1177\/1933719117715129","volume":"25","author":"Z Mao","year":"2018","unstructured":"Mao Z, Fan L, Yu Q, Luo S, Wu X, Tang J, et al. Abnormality of Klotho signaling is involved in polycystic ovary syndrome. Reprod Sci. 2018;25:372\u201383.","journal-title":"Reprod Sci"},{"key":"1876_CR120","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.freeradbiomed.2019.07.010","volume":"141","author":"T Liu","year":"2019","unstructured":"Liu T, Liu Y, Huang Y, Chen J, Yu Z, Chen C, et al. MiR-15b induces premature ovarian failure in mice via inhibition of \u03b1-Klotho expression in ovarian granulosa cells. Free Radic Biol Med. 2019;141:383\u201392.","journal-title":"Free Radic Biol Med"},{"key":"1876_CR121","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1126\/science.1112766","volume":"309","author":"H Kurosu","year":"2005","unstructured":"Kurosu H, Yamamoto M, Clark JD, Pastor JV, Nandi A, Gurnani P, et al. Suppression of aging in mice by the hormone Klotho. Science. 2005;309:1829\u201333.","journal-title":"Science"},{"key":"1876_CR122","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1016\/j.mad.2005.07.007","volume":"126","author":"H Masuda","year":"2005","unstructured":"Masuda H, Chikuda H, Suga T, Kawaguchi H. Regulation of multiple ageing-like phenotypes by inducible klotho gene expression in klotho mutant mice. Mech Ageing Dev. 2005;126:1274\u201383.","journal-title":"Mech Ageing Dev"},{"key":"1876_CR123","doi-asserted-by":"crossref","unstructured":"Umehara T, Winstanley YE, Andreas E, Morimoto A, Williams EJ, Smith KM, Carroll J, Febbraio MA, Shimada M, Russell DL RR. Female reproductive life span is extended by targeted removal of fibrotic collagen from the mouse ovary. Sci Adv. 2022;8(24):eabn4564.","DOI":"10.1126\/sciadv.abn4564"},{"key":"1876_CR124","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/s41422-022-00718-7","volume":"33","author":"L Dong","year":"2023","unstructured":"Dong L, Teh DBL, Kennedy BK, et al. Unraveling female reproductive senescence to enhance healthy longevity. Cell Res. 2023;33:11\u201329.","journal-title":"Cell Res"},{"key":"1876_CR125","doi-asserted-by":"publisher","first-page":"794496","DOI":"10.3389\/fendo.2021.794496","volume":"12","author":"L Jiang","year":"2021","unstructured":"Jiang L, Fei H, Tong J, Zhou J, Zhu J, Jin X, et al. Hormone replacement therapy reverses gut microbiome and serum metabolome alterations in premature ovarian insufficiency. Front Endocrinol. 2021;12:794496.","journal-title":"Front Endocrinol"},{"key":"1876_CR126","doi-asserted-by":"crossref","unstructured":"Landry DA, Yakubovich E, Cook DP, Fasih S, Upham J VB. Metformin prevents age-associated ovarian fibrosis by modulating the immune landscape in female mice. Sci Adv. 2022;8(35):eabq1475.","DOI":"10.1126\/sciadv.abq1475"},{"issue":"3","key":"1876_CR127","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1158\/1078-0432.CCR-19-0603","volume":"26","author":"CW McCloskey","year":"2020","unstructured":"McCloskey CW, Cook DP, Kelly BS, Azzi F, Allen CH, Forsyth A, et al. Metformin abrogates age-associated ovarian fibrosis. Clin Cancer Res. 2020;26(3):632.","journal-title":"Clin Cancer Res"},{"issue":"4","key":"1876_CR128","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1111\/acel.12617","volume":"16","author":"X Dou","year":"2017","unstructured":"Dou X, Sun Y, Li J, Zhang J, Hao D, Liu W, Wu R, Kong F, Peng X. Short-term rapamycin treatment increases ovarian lifespan in young and middle-aged female mice. Aging Cell. 2017;16(4):825 LJ.","journal-title":"Aging Cell"},{"key":"1876_CR129","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1177\/1933719114542016","volume":"22","author":"L Li","year":"2015","unstructured":"Li L, Fu YC, Xu JJ, Lin XH, Chen XC, Zhang XM. Caloric restriction promotes the reserve of follicle pool in adult female rats by inhibiting the activation of mammalian target of rapamycin signaling. Reprod Sci. 2015;22:60 LL.","journal-title":"Reprod Sci"},{"issue":"4","key":"1876_CR130","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1007\/s11357-019-00087-x","volume":"41","author":"DN Garcia","year":"2019","unstructured":"Garcia DN, Saccon TD, Pradiee J, Rinc\u00f3n JAA, Andrade KRS, Rovani MT, et al. Effect of caloric restriction and rapamycin on ovarian aging in mice. Geroscience. 2019;41(4):395\u2013408.","journal-title":"Geroscience"},{"key":"1876_CR131","unstructured":"NIH National Institute on Aging. The interventions testing program - supported interventions. 2024. https:\/\/www.nia.nih.gov\/research\/dab\/interventions."},{"issue":"2","key":"1876_CR132","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1111\/acel.12170","volume":"13","author":"DE Harrison","year":"2014","unstructured":"Harrison DE, Strong R, Allison DB, Ames BN, Astle CM, Atamna H, Fernandez E, Flurkey K, Javors MA, Nadon NL, Nelson JF, Pletcher S, Simpkins JW, Smith D, Wilkinson JE. Acarbose, 17-\u03b1-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males. Aging Cell. 2014;13(2):273 MR.","journal-title":"Aging Cell"},{"issue":"87","key":"1876_CR133","doi-asserted-by":"publisher","first-page":"101922","DOI":"10.1016\/j.arr.2023.101922","volume":"6","author":"AACT Johnson","year":"2023","unstructured":"Johnson AACT. Glycine and aging: evidence and mechanisms. Ageing Res Rev. 2023;6(87):101922.","journal-title":"Ageing Res Rev"},{"issue":"3","key":"1876_CR134","doi-asserted-by":"publisher","first-page":"e12953","DOI":"10.1111\/acel.12953","volume":"19","author":"RA Miller","year":"2019","unstructured":"Miller RA, Harrison DE, Astle CM, Bogue MA, Brind J, Fernandez E, Flurkey K, Javors M, Ladiges W, Leeuwenburgh C, Macchiarini F, Nelson J, Ryazanov AG, Snyder J, Stearns TM, Vaughan DESR. Glycine supplementation extends lifespan of male and female mice. Aging Cell. 2019;19(3):e12953.","journal-title":"Aging Cell"},{"issue":"12","key":"1876_CR135","doi-asserted-by":"publisher","first-page":"e13724","DOI":"10.1111\/acel.13724","volume":"21","author":"R Strong","year":"2022","unstructured":"Strong R, Miller RA, Cheng CJ, Nelson JF, Gelfond J, Allani SK, et al. Lifespan benefits for the combination of rapamycin plus acarbose and for captopril in genetically heterogeneous mice. Aging Cell. 2022;21(12):e13724.","journal-title":"Aging Cell"},{"key":"1876_CR136","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1007\/s00439-012-1184-0","volume":"131","author":"SM Schuh-Huerta","year":"2012","unstructured":"Schuh-Huerta SM, Johnson NA, Rosen MP, et al. Genetic markers of ovarian follicle number and menopause in women of multiple ethnicities. Hum Genet. 2012;131:1709.","journal-title":"Hum Genet"},{"issue":"1","key":"1876_CR137","first-page":"105","volume":"26","author":"ARE Moghadam","year":"2022","unstructured":"Moghadam ARE, Moghadam MT, Hemadi MSG. Oocyte quality and aging. JBRA Assist Reprod. 2022;26(1):105.","journal-title":"JBRA Assist Reprod"},{"issue":"3","key":"1876_CR138","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.fertnstert.2018.04.025","volume":"110","author":"S Herraiz","year":"2018","unstructured":"Herraiz S, Romeu M, Buigues A, Mart\u00ednez S, D\u00edaz-Garc\u00eda C, G\u00f3mez-Segu\u00ed I, Mart\u00ednez J, Pellicer NPA. Autologous stem cell ovarian transplantation to increase reproductive potential in patients who are poor responders. Fertil Steril. 2018;110(3):496\u2013505.","journal-title":"Fertil Steril"},{"issue":"1","key":"1876_CR139","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.ajog.2021.01.023","volume":"225","author":"A Buigues","year":"2021","unstructured":"Buigues A, Marchante M, de Miguel-G\u00f3mez L, Martinez J, Cervell\u00f3 I, Pellicer AHS. Stem cell-secreted factor therapy regenerates the ovarian niche and rescues follicles. Am J Obs Gynecol. 2021;225(1):65.","journal-title":"Am J Obs Gynecol"},{"issue":"2","key":"1876_CR140","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.cell.2022.11.001","volume":"186","author":"C L\u00f3pez-Ot\u00edn","year":"2023","unstructured":"L\u00f3pez-Ot\u00edn C, Blasco MA, Partridge L, Serrano MKG. Hallmarks of aging: an expanding universe. Cell. 2023;186(2):243.","journal-title":"Cell"},{"issue":"5","key":"1876_CR141","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1016\/j.molcel.2016.08.004","volume":"63","author":"RRVJ White","year":"2016","unstructured":"White RRVJ. Do DNA double-strand breaks drive aging? Mol Cell. 2016;63(5):729\u201338.","journal-title":"Mol Cell"},{"key":"1876_CR142","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.1038\/s43587-024-00713-0","volume":"4","author":"Z Huang","year":"2024","unstructured":"Huang Z. Healthy longevity requires bridging reproductive medicine, aging research and public engagement. Nat Aging. 2024;4:1658.","journal-title":"Nat Aging"}],"container-title":["GeroScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11357-025-01876-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11357-025-01876-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11357-025-01876-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T12:02:09Z","timestamp":1783771329000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11357-025-01876-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,10]]},"references-count":142,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["1876"],"URL":"https:\/\/doi.org\/10.1007\/s11357-025-01876-3","relation":{},"ISSN":["2509-2723"],"issn-type":[{"value":"2509-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,10]]},"assertion":[{"value":"19 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}