{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:39:19Z","timestamp":1792035559306,"version":"4.4.0"},"reference-count":100,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["23-15-00124"],"award-info":[{"award-number":["23-15-00124"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["GeroScience"],"DOI":"10.1007\/s11357-025-02005-w","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T06:38:29Z","timestamp":1763015909000},"page":"5957-5986","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Age-related changes in adrenergic regulation of contractility and redox status of glycolytic and oxidative skeletal muscles"],"prefix":"10.1007","volume":"48","author":[{"given":"Julia G.","family":"Odnoshivkina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guzel V.","family":"Sibgatullina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana A.","family":"Dmitrieva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia A.","family":"Ponomareva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venera F.","family":"Khuzakhmetova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellya A.","family":"Bukharaeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1432-3455","authenticated-orcid":false,"given":"Alexey M.","family":"Petrov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,13]]},"reference":[{"key":"2005_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2020.101200","volume":"65","author":"P Wiedmer","year":"2021","unstructured":"Wiedmer P, Jung T, Castro JP, Pomatto LCD, Sun PY, Davies KJA, et al. Sarcopenia - molecular mechanisms and open questions. Ageing Res Rev. 2021;65:101200.","journal-title":"Ageing Res Rev"},{"key":"2005_CR2","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1093\/gerona\/63.8.829","volume":"63","author":"BC Clark","year":"2008","unstructured":"Clark BC, Manini TM. Sarcopenia =\/= dynapenia. J Gerontol A Biol Sci Med Sci. 2008;63:829\u201334.","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"2005_CR3","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.freeradbiomed.2024.11.046","volume":"227","author":"H Xu","year":"2025","unstructured":"Xu H, Brown JL, Bhaskaran S, Van Remmen H. Reactive oxygen species in the pathogenesis of sarcopenia. Free Radic Biol Med. 2025;227:446\u201358.","journal-title":"Free Radic Biol Med"},{"key":"2005_CR4","doi-asserted-by":"publisher","unstructured":"Nishikawa H, Fukunishi S, Asai A, Yokohama K, Nishiguchi S, Higuchi K. Pathophysiology and mechanisms of primary sarcopenia (review). Int J Mol Med. 2021;48:156. https:\/\/doi.org\/10.3892\/ijmm.2021.4989.","DOI":"10.3892\/ijmm.2021.4989"},{"key":"2005_CR5","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1007\/s00424-019-02304-0","volume":"471","author":"SJ Blackwood","year":"2019","unstructured":"Blackwood SJ, Katz A. Isoproterenol enhances force production in mouse glycolytic and oxidative muscle via separate mechanisms. Pflugers Arch. 2019;471:1305\u201316.","journal-title":"Pflugers Arch"},{"key":"2005_CR6","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13690","volume":"6","author":"SR Morris","year":"2018","unstructured":"Morris SR, Gittings W, Vandenboom R. Epinephrine augments posttetanic potentiation in mouse skeletal muscle with and without myosin phosphorylation. Physiol Rep. 2018;6:e13690.","journal-title":"Physiol Rep"},{"key":"2005_CR7","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1111\/j.1476-5381.1993.tb13932.x","volume":"110","author":"SP Cairns","year":"1993","unstructured":"Cairns SP, Dulhunty AF. The effects of beta-adrenoceptor activation on contraction in isolated fast- and slow-twitch skeletal muscle fibres of the rat. Br J Pharmacol. 1993;110:1133\u201341.","journal-title":"Br J Pharmacol"},{"key":"2005_CR8","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/BF00501424","volume":"301","author":"E Holmberg","year":"1977","unstructured":"Holmberg E, Waldeck B. Analysis of the beta-receptor mediated effect on fast-contracting skeletal muscle in vitro. Naunyn Schmiedebergs Arch Pharmacol. 1977;301:109\u201313.","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"2005_CR9","doi-asserted-by":"publisher","first-page":"1268380","DOI":"10.3389\/fphys.2024.1268380","volume":"15","author":"RL Abdalla-Silva","year":"2024","unstructured":"Abdalla-Silva RL, Zanetti GO, Lautherbach N, Schavinski AZ, Heck LC, Goncalves DAP, et al. Beta(2)-adrenoceptors activation regulates muscle trophic-related genes following acute resistance exercise in mice. Front Physiol. 2024;15:1268380.","journal-title":"Front Physiol"},{"key":"2005_CR10","doi-asserted-by":"publisher","first-page":"E663","DOI":"10.1152\/ajpendo.2000.279.3.E663","volume":"279","author":"LC Navegantes","year":"2000","unstructured":"Navegantes LC, Resano NM, Migliorini RH, Kettelhut IC. Role of adrenoceptors and cAMP on the catecholamine-induced inhibition of proteolysis in rat skeletal muscle. Am J Physiol Endocrinol Metab. 2000;279:E663-668.","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2005_CR11","doi-asserted-by":"publisher","first-page":"4713","DOI":"10.1113\/JP270909","volume":"593","author":"SP Cairns","year":"2015","unstructured":"Cairns SP, Borrani F. beta-Adrenergic modulation of skeletal muscle contraction: key role of excitation-contraction coupling. J Physiol. 2015;593:4713\u201327.","journal-title":"J Physiol"},{"key":"2005_CR12","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1152\/physrev.00028.2007","volume":"88","author":"GS Lynch","year":"2008","unstructured":"Lynch GS, Ryall JG. Role of beta-adrenoceptor signaling in skeletal muscle: implications for muscle wasting and disease. Physiol Rev. 2008;88:729\u201367.","journal-title":"Physiol Rev"},{"key":"2005_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101305","volume":"67","author":"O Delbono","year":"2021","unstructured":"Delbono O, Rodrigues ACZ, Bonilla HJ, Messi ML. The emerging role of the sympathetic nervous system in skeletal muscle motor innervation and sarcopenia. Ageing Res Rev. 2021;67:101305.","journal-title":"Ageing Res Rev"},{"key":"2005_CR14","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1186\/s13287-021-02571-8","volume":"12","author":"S Yuan","year":"2021","unstructured":"Yuan S, Zheng S, Zheng K, Gao Y, Chen M, Li Y, et al. Sympathetic activity is correlated with satellite cell aging and myogenesis via beta2-adrenoceptor. Stem Cell Res Ther. 2021;12:505.","journal-title":"Stem Cell Res Ther"},{"key":"2005_CR15","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-33821-9","volume":"13","author":"H Hotta","year":"2023","unstructured":"Hotta H, Iimura K, Watanabe N, Suzuki H, Sugie M, Shigemoto K. Sympathetic modulation of hindlimb muscle contractility is altered in aged rats. Sci Rep. 2023;13:7504.","journal-title":"Sci Rep"},{"key":"2005_CR16","doi-asserted-by":"publisher","first-page":"1908","DOI":"10.1002\/jcsm.12790","volume":"12","author":"ACZ Rodrigues","year":"2021","unstructured":"Rodrigues ACZ, Messi ML, Wang ZM, Bonilla HJ, Freeman WM, Delbono O. Long-term, induced expression of Hand2 in peripheral sympathetic neurons ameliorates sarcopenia in geriatric mice. J Cachexia Sarcopenia Muscle. 2021;12:1908\u201324.","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"2005_CR17","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1113\/jphysiol.2003.056770","volume":"555","author":"JG Ryall","year":"2004","unstructured":"Ryall JG, Plant DR, Gregorevic P, Sillence MN, Lynch GS. Beta 2-agonist administration reverses muscle wasting and improves muscle function in aged rats. J Physiol. 2004;555:175\u201388.","journal-title":"J Physiol"},{"key":"2005_CR18","doi-asserted-by":"crossref","unstructured":"Gon\u00e7alves DA, Silveira WA, Manfredi LH, Gra\u00e7a FA, Armani A, Bertaggia E, O\u00b4 Neill BT, Lautherbach N, Machado J, Nogara L, Pereira MG. Insulin\/IGF1 signalling mediates the effects of \u03b22\u2010adrenergic agonist on muscle proteostasis and growth. Journal of cachexia, sarcopenia and muscle. 2019 10(2):455-75.","DOI":"10.1002\/jcsm.12395"},{"key":"2005_CR19","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.phrs.2015.05.010","volume":"99","author":"V Dutt","year":"2015","unstructured":"Dutt V, Gupta S, Dabur R, Injeti E, Mittal A. Skeletal muscle atrophy: potential therapeutic agents and their mechanisms of action. Pharmacol Res. 2015;99:86\u2013100.","journal-title":"Pharmacol Res"},{"key":"2005_CR20","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1152\/japplphysiol.00317.2007","volume":"105","author":"JG Ryall","year":"2008","unstructured":"Ryall JG, Schertzer JD, Alabakis TM, Gehrig SM, Plant DR, Lynch GS. Intramuscular beta2-agonist administration enhances early regeneration and functional repair in rat skeletal muscle after myotoxic injury. J Appl Physiol (1985). 2008;105:165\u201372.","journal-title":"J Appl Physiol (1985)"},{"key":"2005_CR21","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1093\/gerona\/62.8.813","volume":"62","author":"JG Ryall","year":"2007","unstructured":"Ryall JG, Schertzer JD, Lynch GS. Attenuation of age-related muscle wasting and weakness in rats after formoterol treatment: therapeutic implications for sarcopenia. J Gerontol A Biol Sci Med Sci. 2007;62:813\u201323.","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"2005_CR22","doi-asserted-by":"publisher","first-page":"9130","DOI":"10.1038\/s41598-021-88438-7","volume":"11","author":"T Higashihara","year":"2021","unstructured":"Higashihara T, Nishi H, Takemura K, Watanabe H, Maruyama T, Inagi R, et al. Beta2-adrenergic receptor agonist counteracts skeletal muscle atrophy and oxidative stress in uremic mice. Sci Rep. 2021;11:9130.","journal-title":"Sci Rep"},{"key":"2005_CR23","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.exger.2013.02.012","volume":"48","author":"R Nilwik","year":"2013","unstructured":"Nilwik R, Snijders T, Leenders M, Groen BB, van Kranenburg J, Verdijk LB, et al. The decline in skeletal muscle mass with aging is mainly attributed to a reduction in type II muscle fiber size. Exp Gerontol. 2013;48:492\u20138.","journal-title":"Exp Gerontol"},{"key":"2005_CR24","doi-asserted-by":"crossref","unstructured":"Lexell J, Human aging, muscle mass, and fiber type composition, J Gerontol A Biol Sci Med Sci, 50 Spec No (1995) 11\u201316.","DOI":"10.1093\/gerona\/50A.Special_Issue.11"},{"issue":"1","key":"2005_CR25","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1152\/japplphysiol.00129.2005","volume":"99","author":"KR Short","year":"2005","unstructured":"Short KR, Vittone JL, Bigelow ML, Proctor DN, Coenen-Schimke JM, Rys P, et al. Changes in myosin heavy chain mRNA and protein expression in human skeletal muscle with age and endurance exercise training. J Appl Physiol. 2005;99(1):95\u2013102.","journal-title":"J Appl Physiol"},{"key":"2005_CR26","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-024-06851-y","volume":"15","author":"FM Zhang","year":"2024","unstructured":"Zhang FM, Wu HF, Wang KF, Yu DY, Zhang XZ, Ren Q, et al. Transcriptome profiling of fast\/glycolytic and slow\/oxidative muscle fibers in aging and obesity. Cell Death Dis. 2024;15:459.","journal-title":"Cell Death Dis"},{"key":"2005_CR27","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/S0167-4943(97)00008-3","volume":"25","author":"M Barontini","year":"1997","unstructured":"Barontini M, Lazzari JO, Levin G, Armando I, Basso SJ. Age-related changes in sympathetic activity: biochemical measurements and target organ responses. Arch Gerontol Geriatr. 1997;25:175\u201386.","journal-title":"Arch Gerontol Geriatr"},{"issue":"Suppl 1","key":"2005_CR28","first-page":"S127","volume":"10","author":"H Hotta","year":"2010","unstructured":"Hotta H, Uchida S. Aging of the autonomic nervous system and possible improvements in autonomic activity using somatic afferent stimulation. Geriatr Gerontol Int. 2010;10(Suppl 1):S127-136.","journal-title":"Geriatr Gerontol Int"},{"key":"2005_CR29","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1111\/j.1469-7793.2000.00407.x","volume":"528","author":"DR Seals","year":"2000","unstructured":"Seals DR, Esler MD. Human ageing and the sympathoadrenal system. J Physiol. 2000;528:407\u201317.","journal-title":"J Physiol"},{"key":"2005_CR30","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1023\/A:1015203328878","volume":"3","author":"M Esler","year":"2002","unstructured":"Esler M, Lambert G, Kaye D, Rumantir M, Hastings J, Seals DR. Influence of ageing on the sympathetic nervous system and adrenal medulla at rest and during stress. Biogerontology. 2002;3:45\u20139.","journal-title":"Biogerontology"},{"key":"2005_CR31","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.937132","volume":"13","author":"EC Minchew","year":"2022","unstructured":"Minchew EC, Williamson NC, Readyoff AT, McClung JM, Spangenburg EE. Isometric skeletal muscle contractile properties in common strains of male laboratory mice. Front Physiol. 2022;13:937132.","journal-title":"Front Physiol"},{"key":"2005_CR32","doi-asserted-by":"publisher","unstructured":"Tsentsevitsky AN, Sibgatullina GV, Odoshivkina YG, Khuzakhmetova VF, Tokmakova AR, Ponomareva AA. Functional and structural changes in diaphragm neuromuscular junctions in early aging. Int J Mol Sci. 2024;25:8959. https:\/\/doi.org\/10.3390\/ijms25168959.","DOI":"10.3390\/ijms25168959"},{"key":"2005_CR33","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.ejphar.2015.08.020","volume":"765","author":"UG Odnoshivkina","year":"2015","unstructured":"Odnoshivkina UG, Sytchev VI, Nurullin LF, Giniatullin AR, Zefirov AL, Petrov AM. \u03922-adrenoceptor agonist-evoked reactive oxygen species generation in mouse atria: implication in delayed inotropic effect. Eur J Pharmacol. 2015;765:140\u201353.","journal-title":"Eur J Pharmacol"},{"key":"2005_CR34","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1152\/japplphysiol.00126.2006","volume":"101","author":"CL Mendias","year":"2006","unstructured":"Mendias CL, Marcin JE, Calerdon DR, Faulkner JA. Contractile properties of EDL and soleus muscles of myostatin-deficient mice. J Appl Physiol. 2006;101:898\u2013905.","journal-title":"J Appl Physiol"},{"key":"2005_CR35","first-page":"184","volume":"9","author":"J M\u00e9ndez","year":"1960","unstructured":"M\u00e9ndez J. Density and composition of mammalian muscle. Metabolism. 1960;9:184\u20138.","journal-title":"Metabolism"},{"key":"2005_CR36","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1113\/jphysiol.1988.sp017279","volume":"404","author":"SV Brooks","year":"1988","unstructured":"Brooks SV, Faulkner JA. Contractile properties of skeletal muscles from young, adult and aged mice. J Physiol. 1988;404:71\u201382.","journal-title":"J Physiol"},{"key":"2005_CR37","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-025-04415-w","volume":"50","author":"A Arkhipov","year":"2025","unstructured":"Arkhipov A, Zhilyakov N, Sibgatullina G, Nevsky E, Bukharaeva EA, Petrov AM. Adrenergic modulation of acetylcholine release at the mouse neuromuscular junctions of fast-twitch skeletal muscle. Neurochem Res. 2025;50:162.","journal-title":"Neurochem Res"},{"key":"2005_CR38","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-025-04550-4","volume":"50","author":"GF Zakyrjanova","year":"2025","unstructured":"Zakyrjanova GF, Tsentsevitsky AN, Matigorova VA, Fedorov NS, Odnoshivkina JG, Sibgatullina GV, et al. Cholesterol-lowering treatment suppresses neuromuscular transmission via presynaptic mechanism at the mouse diaphragm muscle. Neurochem Res. 2025;50:298.","journal-title":"Neurochem Res"},{"key":"2005_CR39","doi-asserted-by":"publisher","unstructured":"Zakyrjanova GF, Matigorova VA, Kuznetsova EA, Dmitrieva SA, Tyapkina OV, Tsentsevitsky AN, et al. Key genes and processes affected by atorvastatin treatment in mouse diaphragm muscle. Arch Toxicol. 2025;99:2877\u2013901.\u00a0https:\/\/doi.org\/10.1007\/s00204-025-04056-6.","DOI":"10.1007\/s00204-025-04056-6"},{"key":"2005_CR40","doi-asserted-by":"crossref","unstructured":"Wolff SP. [18] Ferrous ion oxidation in presence of ferric ion indicator xylenol orange for measurement of hydroperoxides. InMethods in enzymology 1994 Jan 1 (Vol. 233, pp. 182-189). Academic Press.","DOI":"10.1016\/S0076-6879(94)33021-2"},{"key":"2005_CR41","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.neuroscience.2018.12.027","volume":"399","author":"A Giniatullin","year":"2019","unstructured":"Giniatullin A, Petrov A, Giniatullin R. Action of hydrogen peroxide on synaptic transmission at the mouse neuromuscular junction. Neuroscience. 2019;399:135\u201345.","journal-title":"Neuroscience"},{"key":"2005_CR42","doi-asserted-by":"publisher","first-page":"31426","DOI":"10.1074\/jbc.M212549200","volume":"278","author":"LJ Niedernhofer","year":"2003","unstructured":"Niedernhofer LJ, Daniels JS, Rouzer CA, Greene RE, Marnett LJ. Malondialdehyde, a product of lipid peroxidation, is mutagenic in human cells. J Biol Chem. 2003;278:31426\u201333.","journal-title":"J Biol Chem"},{"key":"2005_CR43","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","volume":"95","author":"H Ohkawa","year":"1979","unstructured":"Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979;95:351\u20138.","journal-title":"Anal Biochem"},{"key":"2005_CR44","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","volume":"105","author":"H Aebi","year":"1984","unstructured":"Aebi H. Catalase in vitro. Methods Enzymol. 1984;105:121\u20136.","journal-title":"Methods Enzymol"},{"issue":"1","key":"2005_CR45","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/nprot.2009.197","volume":"5","author":"CJ Weydert","year":"2010","unstructured":"Weydert CJ, Cullen JJ. Measurement of superoxide dismutase, catalase and glutathione peroxidase in cultured cells and tissue. Nat Protoc. 2010;5(1):51\u201366.","journal-title":"Nat Protoc"},{"key":"2005_CR46","first-page":"158","volume":"70","author":"DE Paglia","year":"1967","unstructured":"Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med. 1967;70:158\u201369.","journal-title":"J Lab Clin Med"},{"key":"2005_CR47","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/0003-2697(89)90188-7","volume":"183","author":"AE Cribb","year":"1989","unstructured":"Cribb AE, Leeder JS, Spielberg SP. Use of a microplate reader in an assay of glutathione reductase using 5,5\u2019-dithiobis(2-nitrobenzoic acid). Anal Biochem. 1989;183:195\u20136.","journal-title":"Anal Biochem"},{"key":"2005_CR48","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2020.109905","volume":"80","author":"M Ippolito","year":"2021","unstructured":"Ippolito M, Benovic JL. Biased agonism at beta-adrenergic receptors. Cell Signal. 2021;80:109905.","journal-title":"Cell Signal"},{"key":"2005_CR49","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.ejphar.2012.06.036","volume":"690","author":"S Palea","year":"2012","unstructured":"Palea S, Rekik M, Rouget C, Camparo P, Botto H, Rischmann P, et al. Fenoterol functionally activates the beta(3)-adrenoceptor in human urinary bladder, comparison with rat and mouse: implications for drug discovery. Eur J Pharmacol. 2012;690:202\u20136.","journal-title":"Eur J Pharmacol"},{"key":"2005_CR50","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1007\/s00424-024-02913-4","volume":"476","author":"JG Odnoshivkina","year":"2024","unstructured":"Odnoshivkina JG, Averin AS, Khakimov IR, Trusov NA, Trusova DA, Petrov AM. The mechanism of 25-hydroxycholesterol-mediated suppression of atrial beta1-adrenergic responses. Pflugers Arch. 2024;476:407\u201321.","journal-title":"Pflugers Arch"},{"key":"2005_CR51","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1111\/j.1476-5381.2010.00754.x","volume":"160","author":"JG Baker","year":"2010","unstructured":"Baker JG. The selectivity of beta-adrenoceptor agonists at human beta1-, beta2- and beta3-adrenoceptors. Br J Pharmacol. 2010;160:1048\u201361.","journal-title":"Br J Pharmacol"},{"key":"2005_CR52","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.lfs.2015.10.025","volume":"152","author":"S Dutta","year":"2016","unstructured":"Dutta S, Sengupta P. Men and mice: relating their ages. Life Sci. 2016;152:244\u20138.","journal-title":"Life Sci"},{"key":"2005_CR53","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.964130","volume":"10","author":"M Chen","year":"2022","unstructured":"Chen M, Wang Y, Deng S, Lian Z, Yu K. Skeletal muscle oxidative stress and inflammation in aging: focus on antioxidant and anti-inflammatory therapy. Front Cell Dev Biol. 2022;10:964130.","journal-title":"Front Cell Dev Biol"},{"key":"2005_CR54","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-015-9773-1","volume":"37","author":"TG Graber","year":"2015","unstructured":"Graber TG, Kim JH, Grange RW, McLoon LK, Thompson LV. C57BL\/6 life span study: age-related declines in muscle power production and contractile velocity. Age. 2015;37:9773.","journal-title":"Age"},{"key":"2005_CR55","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1093\/gerona\/glx243","volume":"73","author":"C Hill","year":"2018","unstructured":"Hill C, James RS, Cox VM, Tallis J. The effect of increasing age on the concentric and eccentric contractile properties of isolated mouse soleus and extensor digitorum longus muscles. J Gerontol A Biol Sci Med Sci. 2018;73:579\u201387.","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"2005_CR56","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1016\/S0047-6374(01)00229-9","volume":"122","author":"E Gonzalez","year":"2001","unstructured":"Gonzalez E, Delbono O. Age-dependent fatigue in single intact fast- and slow fibers from mouse EDL and soleus skeletal muscles. Mech Ageing Dev. 2001;122:1019\u201332.","journal-title":"Mech Ageing Dev"},{"key":"2005_CR57","doi-asserted-by":"publisher","first-page":"4532","DOI":"10.1021\/pr400644x","volume":"12","author":"DF Chaves","year":"2013","unstructured":"Chaves DF, Carvalho PC, Lima DB, Nicastro H, Lorenzeti FM, Siqueira-Filho M, et al. Comparative proteomic analysis of the aging soleus and extensor digitorum longus rat muscles using TMT labeling and mass spectrometry. J Proteome Res. 2013;12:4532\u201346.","journal-title":"J Proteome Res"},{"issue":"1","key":"2005_CR58","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1152\/jappl.1999.87.1.465","volume":"87","author":"J Bejma","year":"1999","unstructured":"Bejma J, Ji LL. Aging and acute exercise enhance free radical generation in rat skeletal muscle. J Appl Physiol. 1999;87(1):465\u201370.","journal-title":"J Appl Physiol"},{"key":"2005_CR59","doi-asserted-by":"publisher","unstructured":"Eshima H, Shahtout JL, Siripoksup P, Pearson MJ, Mahmassani ZS, Ferrara PJ, et al. Lipid hydroperoxides promote sarcopenia through carbonyl stress. Elife. 2023;12:e85289.\u00a0https:\/\/doi.org\/10.7554\/eLife.85289.","DOI":"10.7554\/eLife.85289"},{"key":"2005_CR60","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1080\/10715760000301451","volume":"33","author":"O Pansarasa","year":"2000","unstructured":"Pansarasa O, Castagna L, Colombi B, Vecchiet J, Felzani G, Marzatico F. Age and sex differences in human skeletal muscle: role of reactive oxygen species. Free Radic Res. 2000;33:287\u201393.","journal-title":"Free Radic Res"},{"key":"2005_CR61","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.exger.2005.08.010","volume":"40","author":"B Marzani","year":"2005","unstructured":"Marzani B, Felzani G, Bellomo RG, Vecchiet J, Marzatico F. Human muscle aging: ROS-mediated alterations in rectus abdominis and vastus lateralis muscles. Exp Gerontol. 2005;40:959\u201365.","journal-title":"Exp Gerontol"},{"key":"2005_CR62","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/S0891-5849(98)00208-1","volume":"26","author":"P Mecocci","year":"1999","unstructured":"Mecocci P, Fano G, Fulle S, MacGarvey U, Shinobu L, Polidori MC, et al. Age-dependent increases in oxidative damage to DNA, lipids, and proteins in human skeletal muscle. Free Radic Biol Med. 1999;26:303\u20138.","journal-title":"Free Radic Biol Med"},{"key":"2005_CR63","doi-asserted-by":"crossref","unstructured":"Brown JL, Peelor FF 3rd, Georgescu C, Wren JD, Kinter M, Tyrrell VJ, et al. Lipid hydroperoxides and oxylipins are mediators of denervation induced muscle atrophy. Redox Biol. 2022;57:102518.","DOI":"10.1016\/j.redox.2022.102518"},{"key":"2005_CR64","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-70792-7","volume":"10","author":"G Pharaoh","year":"2020","unstructured":"Pharaoh G, Brown JL, Sataranatarajan K, Kneis P, Bian J, Ranjit R, et al. Targeting cPLA(2) derived lipid hydroperoxides as a potential intervention for sarcopenia. Sci Rep. 2020;10:13968.","journal-title":"Sci Rep"},{"key":"2005_CR65","first-page":"R918","volume":"258","author":"LL Ji","year":"1990","unstructured":"Ji LL, Dillon D, Wu E. Alteration of antioxidant enzymes with aging in rat skeletal muscle and liver. Am J Physiol. 1990;258:R918-923.","journal-title":"Am J Physiol"},{"key":"2005_CR66","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/S0047-6374(00)00130-5","volume":"116","author":"J Hollander","year":"2000","unstructured":"Hollander J, Bejma J, Ookawara T, Ohno H, Ji LL. Superoxide dismutase gene expression in skeletal muscle: fiber-specific effect of age. Mech Ageing Dev. 2000;116:33\u201345.","journal-title":"Mech Ageing Dev"},{"key":"2005_CR67","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.mad.2006.12.006","volume":"128","author":"RH Lambertucci","year":"2007","unstructured":"Lambertucci RH, Levada-Pires AC, Rossoni LV, Curi R, Pithon-Curi TC. Effects of aerobic exercise training on antioxidant enzyme activities and mRNA levels in soleus muscle from young and aged rats. Mech Ageing Dev. 2007;128:267\u201375.","journal-title":"Mech Ageing Dev"},{"key":"2005_CR68","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1016\/j.mad.2006.08.004","volume":"127","author":"A Vasilaki","year":"2006","unstructured":"Vasilaki A, McArdle F, Iwanejko LM, McArdle A. Adaptive responses of mouse skeletal muscle to contractile activity: the effect of age. Mech Ageing Dev. 2006;127:830\u20139.","journal-title":"Mech Ageing Dev"},{"key":"2005_CR69","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1016\/S0891-5849(98)00144-0","volume":"25","author":"A Lass","year":"1998","unstructured":"Lass A, Sohal BH, Weindruch R, Forster MJ, Sohal RS. Caloric restriction prevents age-associated accrual of oxidative damage to mouse skeletal muscle mitochondria. Free Radic Biol Med. 1998;25:1089\u201397.","journal-title":"Free Radic Biol Med"},{"key":"2005_CR70","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1017\/S0007114516002920","volume":"116","author":"E Rodriguez-Bies","year":"2016","unstructured":"Rodriguez-Bies E, Tung BT, Navas P, Lopez-Lluch G. Resveratrol primes the effects of physical activity in old mice. Br J Nutr. 2016;116:979\u201388.","journal-title":"Br J Nutr"},{"key":"2005_CR71","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2318-13-104","volume":"13","author":"MJ Sullivan-Gunn","year":"2013","unstructured":"Sullivan-Gunn MJ, Lewandowski PA. Elevated hydrogen peroxide and decreased catalase and glutathione peroxidase protection are associated with aging sarcopenia. BMC Geriatr. 2013;13:104.","journal-title":"BMC Geriatr"},{"key":"2005_CR72","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1111\/j.1474-9726.2011.00745.x","volume":"10","author":"M Picard","year":"2011","unstructured":"Picard M, Ritchie D, Thomas MM, Wright KJ, Hepple RT. Alterations in intrinsic mitochondrial function with aging are fiber type-specific and do not explain differential atrophy between muscles. Aging Cell. 2011;10:1047\u201355.","journal-title":"Aging Cell"},{"key":"2005_CR73","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/S0891-5849(99)00108-2","volume":"27","author":"O Pansarasa","year":"1999","unstructured":"Pansarasa O, Bertorelli L, Vecchiet J, Felzani G, Marzatico F. Age-dependent changes of antioxidant activities and markers of free radical damage in human skeletal muscle. Free Radic Biol Med. 1999;27:617\u201322.","journal-title":"Free Radic Biol Med"},{"key":"2005_CR74","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.1016\/j.freeradbiomed.2006.01.036","volume":"40","author":"FL Muller","year":"2006","unstructured":"Muller FL, Song W, Liu Y, Chaudhuri A, Pieke-Dahl S, Strong R, et al. Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy. Free Radic Biol Med. 2006;40:1993\u20132004.","journal-title":"Free Radic Biol Med"},{"key":"2005_CR75","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1002\/ana.25144","volume":"83","author":"B Joureau","year":"2018","unstructured":"Joureau B, de Winter JM, Conijn S, Bogaards SJP, Kovacevic I, Kalganov A, et al. Dysfunctional sarcomere contractility contributes to muscle weakness in ACTA1-related nemaline myopathy (NEM3). Ann Neurol. 2018;83:269\u201382.","journal-title":"Ann Neurol"},{"key":"2005_CR76","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1292\/jvms.70.115","volume":"70","author":"T Kobayashi","year":"2008","unstructured":"Kobayashi T, Takita Y, Suzuki A, Katsu Y, Iguchi T, Ohta Y. Vacuolar degeneration of skeletal muscle in transgenic mice overexpressing ORP150. J Vet Med Sci. 2008;70:115\u20138.","journal-title":"J Vet Med Sci"},{"key":"2005_CR77","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1007\/BF00228590","volume":"86","author":"M Uchino","year":"1993","unstructured":"Uchino M, Uyama E, Hirano T, Nakamura T, Fukushima T, Ando M. A histochemical and electron microscopic study of skeletal muscle in an adult case of Chediak-Higashi syndrome. Acta Neuropathol. 1993;86:521\u20134.","journal-title":"Acta Neuropathol"},{"key":"2005_CR78","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-21741-z","volume":"12","author":"J Pingel","year":"2022","unstructured":"Pingel J, Kjer HM, Biering-Sorensen F, Feidenhans\u2019l R, Dyrby TB. 3D synchrotron imaging of muscle tissues at different atrophic stages in stroke and spinal cord injury: a proof-of-concept study. Sci Rep. 2022;12:17289.","journal-title":"Sci Rep"},{"key":"2005_CR79","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1196\/annals.1404.008","volume":"1119","author":"T Jung","year":"2007","unstructured":"Jung T, Bader N, Grune T. Lipofuscin: formation, distribution, and metabolic consequences. Ann N Y Acad Sci. 2007;1119:97\u2013111.","journal-title":"Ann N Y Acad Sci"},{"key":"2005_CR80","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1111\/j.1748-1716.1978.tb06277.x","volume":"104","author":"J Orlander","year":"1978","unstructured":"Orlander J, Kiessling KH, Larsson L, Karlsson J, Aniansson A. Skeletal muscle metabolism and ultrastructure in relation to age in sedentary men. Acta Physiol Scand. 1978;104:249\u201361.","journal-title":"Acta Physiol Scand"},{"key":"2005_CR81","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1023\/B:HIJO.0000045947.83628.a7","volume":"35","author":"Y Nakae","year":"2004","unstructured":"Nakae Y, Stoward PJ, Kashiyama T, Shono M, Akagi A, Matsuzaki T, et al. Early onset of lipofuscin accumulation in dystrophin-deficient skeletal muscles of DMD patients and mdx mice. J Mol Histol. 2004;35:489\u201399.","journal-title":"J Mol Histol"},{"key":"2005_CR82","doi-asserted-by":"publisher","DOI":"10.1186\/2051-5960-2-2","volume":"2","author":"EJ Feeney","year":"2014","unstructured":"Feeney EJ, Austin S, Chien YH, Mandel H, Schoser B, Prater S, et al. The value of muscle biopsies in Pompe disease: identifying lipofuscin inclusions in juvenile- and adult-onset patients. Acta Neuropathol Commun. 2014;2:2.","journal-title":"Acta Neuropathol Commun"},{"issue":"9","key":"2005_CR83","doi-asserted-by":"publisher","first-page":"6805","DOI":"10.1007\/s12035-024-03991-2","volume":"61","author":"CR Gafurova","year":"2024","unstructured":"Gafurova CR, Tsentsevitsky AN, Fedorov NS, Khaziev AN, Malomouzh AI, Petrov AM. \u03922-adrenergic regulation of the neuromuscular transmission and its lipid-dependent switch. Mol Neurobiol. 2024;61(9):6805\u201321.","journal-title":"Mol Neurobiol"},{"key":"2005_CR84","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1073\/pnas.1524272113","volume":"113","author":"MM Khan","year":"2016","unstructured":"Khan MM, Lustrino D, Silveira WA, Wild F, Straka T, Issop Y, et al. Sympathetic innervation controls homeostasis of neuromuscular junctions in health and disease. Proc Natl Acad Sci USA. 2016;113:746\u201350.","journal-title":"Proc Natl Acad Sci USA"},{"key":"2005_CR85","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1111\/j.1476-5381.1996.tb15176.x","volume":"117","author":"BA Evans","year":"1996","unstructured":"Evans BA, Papaioannou M, Bonazzi VR, Summers RJ. Expression of beta 3-adrenoceptor mRNA in rat tissues. Br J Pharmacol. 1996;117:210\u20136.","journal-title":"Br J Pharmacol"},{"key":"2005_CR86","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1007\/s12576-009-0046-6","volume":"59","author":"F Kawano","year":"2009","unstructured":"Kawano F, Tanihata J, Sato S, Nomura S, Shiraishi A, Tachiyashiki K, et al. Effects of dexamethasone on the expression of beta(1)-, beta (2)- and beta (3)-adrenoceptor mRNAs in skeletal and left ventricle muscles in rats. J Physiol Sci. 2009;59:383\u201390.","journal-title":"J Physiol Sci"},{"key":"2005_CR87","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1038\/sj.ijo.0801039","volume":"23","author":"PD Chamberlain","year":"1999","unstructured":"Chamberlain PD, Jennings KH, Paul F, Cordell J, Berry A, Holmes SD, et al. The tissue distribution of the human beta3-adrenoceptor studied using a monoclonal antibody: direct evidence of the beta3-adrenoceptor in human adipose tissue, atrium and skeletal muscle. Int J Obes Relat Metab Disord. 1999;23:1057\u201365.","journal-title":"Int J Obes Relat Metab Disord"},{"key":"2005_CR88","doi-asserted-by":"publisher","first-page":"552","DOI":"10.3803\/EnM.2022.1421","volume":"37","author":"MJ Park","year":"2022","unstructured":"Park MJ, Kim JW, Roh E, Choi KM, Baik SH, Hwang HJ, et al. Sestrin2 regulates beneficial beta3-adrenergic receptor-mediated effects observed in inguinal white adipose tissue and soleus muscle. Endocrinol Metab (Seoul). 2022;37:552\u20137.","journal-title":"Endocrinol Metab (Seoul)"},{"key":"2005_CR89","doi-asserted-by":"publisher","first-page":"37504","DOI":"10.1038\/srep37504","volume":"5","author":"D Puzzo","year":"2016","unstructured":"Puzzo D, Raiteri R, Castaldo C, Capasso R, Pagano E, Tedesco M, et al. CL316,243, a beta3-adrenergic receptor agonist, induces muscle hypertrophy and increased strength. Sci Rep. 2016;5:37504.","journal-title":"Sci Rep"},{"key":"2005_CR90","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1007\/s00424-012-1213-9","volume":"465","author":"MC Miniaci","year":"2013","unstructured":"Miniaci MC, Bucci M, Santamaria R, Irace C, Cantalupo A, Cirino G, et al. CL316,243, a selective beta3-adrenoceptor agonist, activates protein translation through mTOR\/p70S6K signaling pathway in rat skeletal muscle cells. Pflugers Arch. 2013;465:509\u201316.","journal-title":"Pflugers Arch"},{"key":"2005_CR91","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/S0014-2999(00)00671-3","volume":"406","author":"M Board","year":"2000","unstructured":"Board M, Doyle P, Cawthorne MA. BRL37344, but not CGP12177, stimulates fuel oxidation by soleus muscle in vitro. Eur J Pharmacol. 2000;406:33\u201340.","journal-title":"Eur J Pharmacol"},{"key":"2005_CR92","doi-asserted-by":"publisher","first-page":"2898","DOI":"10.1172\/JCI118748","volume":"97","author":"I Nagase","year":"1996","unstructured":"Nagase I, Yoshida T, Kumamoto K, Umekawa T, Sakane N, Nikami H, et al. Expression of uncoupling protein in skeletal muscle and white fat of obese mice treated with thermogenic beta 3-adrenergic agonist. J Clin Invest. 1996;97:2898\u2013904.","journal-title":"J Clin Invest"},{"key":"2005_CR93","doi-asserted-by":"publisher","first-page":"2319","DOI":"10.1172\/JCI134892","volume":"130","author":"BS Finlin","year":"2020","unstructured":"Finlin BS, Memetimin H, Zhu B, Confides AL, Vekaria HJ, El Khouli RH, et al. The beta3-adrenergic receptor agonist mirabegron improves glucose homeostasis in obese humans. J Clin Invest. 2020;130:2319\u201331.","journal-title":"J Clin Invest"},{"key":"2005_CR94","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-025-02370-9","volume":"163","author":"EA Kuznetsova","year":"2025","unstructured":"Kuznetsova EA, Fedorov NS, Zakyrjanova GF, Malomouzh AI, Petrov AM. 25-hydroxycholesterol as a negative regulator of diaphragm muscle contractions via estrogen receptor and Ca(2+) -dependent pathway. Histochem Cell Biol. 2025;163:42.","journal-title":"Histochem Cell Biol"},{"key":"2005_CR95","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1007\/BF02181463","volume":"408","author":"RC Carlsen","year":"1987","unstructured":"Carlsen RC, Walsh DA. Decrease in force potentiation and appearance of alpha-adrenergic mediated contracture in aging rat skeletal muscle. Pflugers Arch. 1987;408:224\u201330.","journal-title":"Pflugers Arch"},{"key":"2005_CR96","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.ando.2020.03.012","volume":"82","author":"J Motiejunaite","year":"2021","unstructured":"Motiejunaite J, Amar L, Vidal-Petiot E. Adrenergic receptors and cardiovascular effects of catecholamines. Ann Endocrinol (Paris). 2021;82:193\u20137.","journal-title":"Ann Endocrinol (Paris)"},{"key":"2005_CR97","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1113\/jphysiol.1981.sp013805","volume":"316","author":"L Grimby","year":"1981","unstructured":"Grimby L, Hannerz J, Hedman B. The fatigue and voluntary discharge properties of single motor units in man. J Physiol. 1981;316:545\u201354.","journal-title":"J Physiol"},{"key":"2005_CR98","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1242\/jeb.115.1.125","volume":"115","author":"CJ De Luca","year":"1985","unstructured":"De Luca CJ. Control properties of motor units. J Exp Biol. 1985;115:125\u201336.","journal-title":"J Exp Biol"},{"key":"2005_CR99","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1038\/314164a0","volume":"314","author":"R Hennig","year":"1985","unstructured":"Hennig R, Lomo T. Firing patterns of motor units in normal rats. Nature. 1985;314:164\u20136.","journal-title":"Nature"},{"key":"2005_CR100","doi-asserted-by":"publisher","first-page":"2002","DOI":"10.1152\/jn.2000.83.4.2002","volume":"83","author":"M Gorassini","year":"2000","unstructured":"Gorassini M, Eken T, Bennett DJ, Kiehn O, Hultborn H. Activity of hindlimb motor units during locomotion in the conscious rat. J Neurophysiol. 2000;83:2002\u201311.","journal-title":"J Neurophysiol"}],"container-title":["GeroScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11357-025-02005-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11357-025-02005-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11357-025-02005-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T15:05:45Z","timestamp":1789398345000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11357-025-02005-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,13]]},"references-count":100,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["2005"],"URL":"https:\/\/doi.org\/10.1007\/s11357-025-02005-w","relation":{},"ISSN":["2509-2723"],"issn-type":[{"value":"2509-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,13]]},"assertion":[{"value":"29 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The experimental protocols (Protocols #23\u20131\/23\u20132\/2, #23\u20134\/6, 28 February,2023; #23\/7 12 May 2023) were approved by the Bioethics Committee of Kazan Federal Scientific Centre and met the requirements of the EU Directive 2010\/63\/EU as well as European Convention for the Protection of Vertebrate Animals used for Experimental and other Scientific Purposes (Council of Europe No 123, Strasbourg, 1985).","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for Publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. All authors consent to publish the article.","order":3,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}