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Seventy-seven participants were randomized to receive a 6-week cognitive training with either HomeCoRe (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200940) or CoRe (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200937). Global cognition, specific cognitive domains, and well-being were assessed at baseline and after training. Participant-centered outcomes were also examined, including Weighted Scores, which offer a composite measure capturing both individual session performance and overall rehabilitation progress. Results showed that HomeCoRe was non-inferior to CoRe in improving cognition. Both groups showed significant gains in working memory (\n                    <jats:italic>p<\/jats:italic>\n                    <jats:sub>HomeCoRe<\/jats:sub>\n                    \u2009=\u20090.03;\n                    <jats:italic>p<\/jats:italic>\n                    <jats:sub>CoRe<\/jats:sub>\n                    \u2009=\u20090.005) and logical-executive functions (\n                    <jats:italic>p<\/jats:italic>\n                    <jats:sub>HomeCoRe<\/jats:sub>\n                    \u2009=\u20090.003;\n                    <jats:italic>p<\/jats:italic>\n                    <jats:sub>CoRe<\/jats:sub>\n                    \u2009=\u20090.002), while only HomeCoRe was found to improve global cognition (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.01). Weighted Scores significantly increased in both groups (\n                    <jats:italic>p<\/jats:italic>\n                    <jats:sub>HomeCoRe<\/jats:sub>\n                    \u2009=\u20090.001;\n                    <jats:italic>p<\/jats:italic>\n                    <jats:sub>CoRe<\/jats:sub>\n                    \u2009&lt;\u20090.001). No significant differences emerged in mood or mental health outcomes. This study provides important evidence on how the mode of delivery can influence cognitive rehabilitation outcomes, representing one of the first RCTs to assess the same intervention delivered both in-person and remotely. The demonstration of HomeCoRe\u2019s non-inferiority highlights the potential of this promising alternative to in-clinic rehabilitation, promoting accessibility, engagement, and autonomy. Clinicaltrials.gov\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04889560\" ext-link-type=\"uri\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04889560<\/jats:ext-link>\n                    (registration date: May 17, 2021).\n                  <\/jats:p>","DOI":"10.1007\/s11357-025-02006-9","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T02:10:28Z","timestamp":1762999828000},"page":"121-134","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["HomeCoRe for telerehabilitation in mild or major neurocognitive disorders: a non-inferiority randomized controlled trial"],"prefix":"10.1007","volume":"48","author":[{"given":"Sara","family":"Bernini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Valcarenghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Panzarasa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvana","family":"Quaglini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo Cotta","family":"Ramusino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Picascia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marica","family":"Barbieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Tassorelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomaso","family":"Vecchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0151-3962","authenticated-orcid":false,"given":"Sara","family":"Bottiroli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,13]]},"reference":[{"key":"2006_CR1","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1176\/appi.ajp.2016.16030360","volume":"174","author":"NTM Hill","year":"2017","unstructured":"Hill NTM, Mowszowski L, Naismith SL, Chadwick VL, Valenzuela M, Lampit A. 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