{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:02:35Z","timestamp":1790143355532,"version":"4.0.1"},"reference-count":80,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T00:00:00Z","timestamp":1765584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T00:00:00Z","timestamp":1765584000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R15AG061795"],"award-info":[{"award-number":["R15AG061795"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R56AG074499"],"award-info":[{"award-number":["R56AG074499"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG069742"],"award-info":[{"award-number":["R01AG069742"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ed and Ethel Moore Alzheimer's Disease Research Program, Florida Department of Health","award":["24A12"],"award-info":[{"award-number":["24A12"]}],"id":[{"id":"https:\/\/ror.org\/03e1xkn26","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Nathan Shock Center Pilot Funding Program, San Antonio Nathan Shock Center","award":["P30 AG050911"],"award-info":[{"award-number":["P30 AG050911"]}]},{"name":"The Global Consortium for Reproductive Longevity and Equality","award":["GCRLE-4501"],"award-info":[{"award-number":["GCRLE-4501"]}]},{"DOI":"10.13039\/100001298","name":"Presbyterian Health Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001298","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007199","name":"Utah Agricultural Experiment Station","doi-asserted-by":"publisher","award":["UTA01159"],"award-info":[{"award-number":["UTA01159"]}],"id":[{"id":"10.13039\/100007199","id-type":"DOI","asserted-by":"publisher"}]},{"name":"IDeA National Resource for Quantitative Proteomics, University of Arkansas for Medical sciences","id":[{"id":"https:\/\/ror.org\/00xcryt71","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Utah State University, College of Veterinary Medicine","id":[{"id":"https:\/\/ror.org\/00h6set76","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Utah State University, Department of Veterinary Clinical and Life Sciences","id":[{"id":"https:\/\/ror.org\/00h6set76","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006630","name":"Utah State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006630","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["GeroScience"],"DOI":"10.1007\/s11357-025-02019-4","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T02:34:38Z","timestamp":1765593278000},"page":"7139-7155","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Ovarian somatic tissue rejuvenates circulating apolipoproteins and promotes cognitive health in postreproductive female mice"],"prefix":"10.1007","volume":"48","author":[{"given":"Nathan D.","family":"McCoy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven P.","family":"Gawrys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel G.","family":"Mackintosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Byrum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negar","family":"Kosari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anhong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mishfak A. M.","family":"Mansoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Ikeno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 V. V.","family":"Isola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Stout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusto","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal M.","family":"Masternak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2459-1186","authenticated-orcid":false,"given":"Jeffrey B.","family":"Mason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,13]]},"reference":[{"issue":"1","key":"2019_CR1","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1093\/gerona\/glw048","volume":"72","author":"M Jov\u00e9","year":"2017","unstructured":"Jov\u00e9 M, Naud\u00ed A, Gambini J, Borras C, Cabr\u00e9 R, Portero-Ot\u00edn M, et al. A stress-resistant lipidomic signature confers extreme longevity to humans. J Gerontol A Biol Sci Med Sci. 2017;72(1):30\u20137. https:\/\/doi.org\/10.1093\/gerona\/glw048.","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"2019_CR2","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.jprot.2017.11.001","volume":"178","author":"M Audano","year":"2018","unstructured":"Audano M, Maldini M, De Fabiani E, Mitro N, Caruso D. Gender-related metabolomics and lipidomics: from experimental animal models to clinical evidence. J Proteomics. 2018;178:82\u201391. https:\/\/doi.org\/10.1016\/j.jprot.2017.11.001.","journal-title":"J Proteomics"},{"issue":"25","key":"2019_CR3","doi-asserted-by":"publisher","first-page":"2366","DOI":"10.1016\/j.jacc.2009.10.009","volume":"54","author":"KA Matthews","year":"2009","unstructured":"Matthews KA, Crawford SL, Chae CU, Everson-Rose SA, Sowers MF, Sternfeld B, et al. Are changes in cardiovascular disease risk factors in midlife women due to chronological aging or to the menopausal transition? J Am Coll Cardiol. 2009;54(25):2366\u201373. https:\/\/doi.org\/10.1016\/j.jacc.2009.10.009.","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"2019_CR4","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1080\/01616412.2000.11740678","volume":"22","author":"K Kalman","year":"2000","unstructured":"Kalman K, McConathy W, Araoz C, Kasa P, Lacko AG. Apolipoprotein D in the aging brain and in Alzheimer\u2019s dementia. Neurol Res. 2000;22(4):330\u20136. https:\/\/doi.org\/10.1080\/01616412.2000.11740678.","journal-title":"Neurol Res"},{"issue":"6","key":"2019_CR5","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1194\/jlr.M001206","volume":"51","author":"G Perdomo","year":"2010","unstructured":"Perdomo G, Kim DH, Zhang T, Qu S, Thomas EA, Toledo FGS, et al. A role of apolipoprotein D in triglyceride metabolism[S]. J Lipid Res. 2010;51(6):1298\u2013311. https:\/\/doi.org\/10.1194\/jlr.M001206.","journal-title":"J Lipid Res"},{"issue":"12","key":"2019_CR6","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1016\/j.metabol.2011.04.013","volume":"60","author":"M Jim\u00e9nez-Palomares","year":"2011","unstructured":"Jim\u00e9nez-Palomares M, C\u00f3zar-Castellano I, Ganfornina MD, S\u00e1nchez D, Perdomo G. Genetic deficiency of apolipoprotein D in the mouse is associated with nonfasting hypertriglyceridemia and hyperinsulinemia. Metabolism. 2011;60(12):1767\u201374. https:\/\/doi.org\/10.1016\/j.metabol.2011.04.013.","journal-title":"Metabolism"},{"key":"2019_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2020.144874","volume":"756","author":"E Rassart","year":"2020","unstructured":"Rassart E, Desmarais F, Najyb O, Bergeron K-F, Mounier C. Apolipoprotein D. Gene. 2020;756:144874. https:\/\/doi.org\/10.1016\/j.gene.2020.144874.","journal-title":"Gene"},{"key":"2019_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2020.146685","volume":"1733","author":"K Krishnamurthy","year":"2020","unstructured":"Krishnamurthy K, Cantillana V, Wang H, Sullivan PM, Kolls BJ, Ge X, et al. ApoE mimetic improves pathology and memory in a model of Alzheimer\u2019s disease. Brain Res. 2020;1733:146685. https:\/\/doi.org\/10.1016\/j.brainres.2020.146685.","journal-title":"Brain Res"},{"issue":"7937","key":"2019_CR9","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1038\/s41586-022-05439-w","volume":"611","author":"JW Blanchard","year":"2022","unstructured":"Blanchard JW, Akay LA, Davila-Velderrain J, von Maydell D, Mathys H, Davidson SM, et al. APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes. Nature. 2022;611(7937):769\u201379. https:\/\/doi.org\/10.1038\/s41586-022-05439-w.","journal-title":"Nature"},{"issue":"1","key":"2019_CR10","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-022-01058-9","volume":"14","author":"A Giannisis","year":"2022","unstructured":"Giannisis A, Al-Grety A, Carlsson H, Patra K, Twohig D, Sando SB, et al. Plasma apolipoprotein E levels in longitudinally followed patients with mild cognitive impairment and Alzheimer\u2019s disease. Alzheimers Res Ther. 2022;14(1):115. https:\/\/doi.org\/10.1186\/s13195-022-01058-9.","journal-title":"Alzheimers Res Ther"},{"issue":"8","key":"2019_CR11","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.43053","volume":"15","author":"N Ali","year":"2023","unstructured":"Ali N, Sohail R, Jaffer SR, Siddique S, Kaya B, Atowoju I, et al. The role of estrogen therapy as a protective factor for Alzheimer\u2019s disease and dementia in postmenopausal women: a comprehensive review of the literature. Cureus. 2023;15(8):e43053. https:\/\/doi.org\/10.7759\/cureus.43053.","journal-title":"Cureus"},{"key":"2019_CR12","doi-asserted-by":"publisher","first-page":"1350318","DOI":"10.3389\/fendo.2024.1350318","volume":"15","author":"C Andy","year":"2024","unstructured":"Andy C, Nerattini M, Jett S, Carlton C, Zarate C, Boneu C, et al. Systematic review and meta-analysis of the effects of menopause hormone therapy on cognition. Front Endocrinol. 2024;15:1350318. https:\/\/doi.org\/10.3389\/fendo.2024.1350318.","journal-title":"Front Endocrinol"},{"issue":"3","key":"2019_CR13","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/S1474-4422(05)01016-1","volume":"4","author":"MC Craig","year":"2005","unstructured":"Craig MC, Maki PM, Murphy DG. The women\u2019s health initiative memory study: findings and implications for treatment. Lancet Neurol. 2005;4(3):190\u20134. https:\/\/doi.org\/10.1016\/S1474-4422(05)01016-1.","journal-title":"Lancet Neurol"},{"issue":"5","key":"2019_CR14","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1001\/jamaneurol.2023.0455","volume":"80","author":"GT Coughlan","year":"2023","unstructured":"Coughlan GT, Betthauser TJ, Boyle R, Koscik RL, Klinger HM, Chibnik LB, et al. Association of age at menopause and hormone therapy use with tau and \u03b2-amyloid positron emission tomography. JAMA Neurol. 2023;80(5):462\u201373. https:\/\/doi.org\/10.1001\/jamaneurol.2023.0455.","journal-title":"JAMA Neurol"},{"issue":"39","key":"2019_CR15","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adp2442","volume":"10","author":"S Artham","year":"2024","unstructured":"Artham S, Juras PK, Goyal A, Chakraborty P, Byemerwa J, Liu S, et al. Estrogen signaling suppresses tumor-associated tissue eosinophilia to promote breast tumor growth. Sci Adv. 2024;10(39):eadp2442. https:\/\/doi.org\/10.1126\/sciadv.adp2442.","journal-title":"Sci Adv"},{"issue":"2","key":"2019_CR16","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.amjms.2017.06.011","volume":"354","author":"VA Fonseca","year":"2017","unstructured":"Fonseca VA, Lovre D. Diabetes-related dyslipidemia and cardiovascular events. Am J Med Sci. 2017;354(2):103\u20134. https:\/\/doi.org\/10.1016\/j.amjms.2017.06.011.","journal-title":"Am J Med Sci"},{"issue":"18","key":"2019_CR17","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.021362","volume":"10","author":"KA Matthews","year":"2021","unstructured":"Matthews KA, Chen X, Barinas\u2010Mitchell E, Brooks MM, Derby CA, Harlow S, et al. Age at menopause in relationship to lipid changes and subclinical carotid disease across 20 years: study of women\u2019s health across the nation. J Am Heart Assoc. 2021;10(18):e021362. https:\/\/doi.org\/10.1161\/JAHA.121.021362.","journal-title":"J Am Heart Assoc"},{"issue":"2","key":"2019_CR18","first-page":"1","volume":"2","author":"T Habermehl","year":"2018","unstructured":"Habermehl T, Parkinson K, Mason J. Germ cell depletion influenced neuromuscular, sensory, renal and metabolic function in postreproductive female mice. Obstetrics & Gynecology: Open Access. 2018;2(2):1\u201315.","journal-title":"Obstetrics & Gynecology: Open Access"},{"issue":"1","key":"2019_CR19","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s11357-018-0049-4","volume":"41","author":"TL Habermehl","year":"2019","unstructured":"Habermehl TL, Parkinson KC, Hubbard GB, Ikeno Y, Engelmeyer JI, Schumacher B, et al. Extension of longevity and reduction of inflammation is ovarian-dependent, but germ cell-independent in post-reproductive female mice. Geroscience. 2019;41(1):25\u201338. https:\/\/doi.org\/10.1007\/s11357-018-0049-4.","journal-title":"Geroscience"},{"issue":"1","key":"2019_CR20","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8010040","volume":"8","author":"TL Habermehl","year":"2019","unstructured":"Habermehl TL, Mason JB. Decreased sarcopenia in aged females with young ovary transplants was preserved in mice that received germ cell-depleted young ovaries. J Clin Med. 2019;8(1):40. https:\/\/doi.org\/10.3390\/jcm8010040.","journal-title":"J Clin Med"},{"key":"2019_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2019.110686","volume":"126","author":"KA Tyler","year":"2019","unstructured":"Tyler KA, Habermehl TL, Mason JB. Manipulation of ovarian function influenced glucose metabolism in CBA\/J mice. Exp Gerontol. 2019;126:110686. https:\/\/doi.org\/10.1016\/j.exger.2019.110686.","journal-title":"Exp Gerontol"},{"issue":"4","key":"2019_CR22","doi-asserted-by":"publisher","first-page":"2157","DOI":"10.1007\/s11357-022-00549-9","volume":"44","author":"TL Habermehl","year":"2022","unstructured":"Habermehl TL, Underwood KB, Welch KD, Gawrys SP, Parkinson KC, Schneider A, et al. Aging-associated changes in motor function are ovarian somatic tissue-dependent, but germ cell and estradiol independent in post-reproductive female mice exposed to young ovarian tissue. Geroscience. 2022;44(4):2157\u201369. https:\/\/doi.org\/10.1007\/s11357-022-00549-9.","journal-title":"Geroscience"},{"issue":"1","key":"2019_CR23","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1093\/gerona\/glab252","volume":"77","author":"JB Mason","year":"2022","unstructured":"Mason JB, Habermehl TL, Underwood KB, Schneider A, Brie\u00f1o-Enriquez MA, Masternak MM, et al. The interrelationship between female reproductive aging and survival. J Gerontol A Biol Sci Med Sci. 2022;77(1):75\u201383. https:\/\/doi.org\/10.1093\/gerona\/glab252.","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"2019_CR24","doi-asserted-by":"publisher","first-page":"1066356","DOI":"10.3389\/fendo.2023.1066356","volume":"14","author":"TL King","year":"2023","unstructured":"King TL, Bryner BS, Underwood KB, Walters MR, Zimmerman SM, Johnson NK, et al. Estradiol-independent restoration of T-cell function in post-reproductive females. Front Endocrinol. 2023;14:1066356. https:\/\/doi.org\/10.3389\/fendo.2023.1066356.","journal-title":"Front Endocrinol"},{"issue":"1","key":"2019_CR25","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1038\/s43587-023-00552-5","volume":"4","author":"JVV Isola","year":"2024","unstructured":"Isola JVV, Oca\u00f1as SR, Hubbart CR, Ko S, Mondal SA, Hense JD, et al. A single-cell atlas of the aging mouse ovary. Nat Aging. 2024;4(1):145\u201362. https:\/\/doi.org\/10.1038\/s43587-023-00552-5.","journal-title":"Nat Aging"},{"issue":"1","key":"2019_CR26","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1055\/s-2007-992933","volume":"26","author":"PH Kodaman","year":"2008","unstructured":"Kodaman PH, Duleba AJ. Statins: do they have potential in the treatment of polycystic ovary syndrome? Semin Reprod Med. 2008;26(1):127\u201338. https:\/\/doi.org\/10.1055\/s-2007-992933.","journal-title":"Semin Reprod Med"},{"issue":"4","key":"2019_CR27","doi-asserted-by":"publisher","first-page":"277","DOI":"10.5152\/dir.2015.34414","volume":"21","author":"M Horta","year":"2015","unstructured":"Horta M, Cunha TM. Sex cord-stromal tumors of the ovary: a comprehensive review and update for radiologists. Diagn Interv Radiol. 2015;21(4):277\u201386. https:\/\/doi.org\/10.5152\/dir.2015.34414.","journal-title":"Diagn Interv Radiol"},{"issue":"5","key":"2019_CR28","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1016\/j.jhep.2008.06.029","volume":"49","author":"E Kim","year":"2008","unstructured":"Kim E, Li K, Lieu C, Tong S, Kawai S, Fukutomi T, et al. Expression of apolipoprotein C-IV is regulated by Ku antigen\/peroxisome proliferator-activated receptor \u03b3 complex and correlates with liver steatosis. J Hepatol. 2008;49(5):787\u201398. https:\/\/doi.org\/10.1016\/j.jhep.2008.06.029.","journal-title":"J Hepatol"},{"issue":"3","key":"2019_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2024.104073","volume":"49","author":"AC de Kat","year":"2024","unstructured":"de Kat AC, Roelofs F, Slagboom PE, Broekmans FJM, Beekman M, van den Berg N. Late reproduction is associated with extended female survival but not with familial longevity. Reprod Biomed Online. 2024;49(3):104073. https:\/\/doi.org\/10.1016\/j.rbmo.2024.104073.","journal-title":"Reprod Biomed Online"},{"issue":"10","key":"2019_CR30","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1093\/eurjpc\/zwac060","volume":"29","author":"JE Karppinen","year":"2022","unstructured":"Karppinen JE, T\u00f6rm\u00e4kangas T, Kujala UM, Sipil\u00e4 S, Laukkanen J, Aukee P, et al. Menopause modulates the circulating metabolome: evidence from a prospective cohort study. Eur J Prev Cardiol. 2022;29(10):1448\u201359. https:\/\/doi.org\/10.1093\/eurjpc\/zwac060.","journal-title":"Eur J Prev Cardiol"},{"issue":"6","key":"2019_CR31","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.exger.2010.03.010","volume":"45","author":"JB Mason","year":"2010","unstructured":"Mason JB, Cargill SL, Anderson GB, Carey JR. Ovarian status influenced the rate of body-weight change but not the total amount of body-weight gained or lost in female CBA\/J mice. Exp Gerontol. 2010;45(6):435\u201341. https:\/\/doi.org\/10.1016\/j.exger.2010.03.010.","journal-title":"Exp Gerontol"},{"issue":"12","key":"2019_CR32","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1093\/gerona\/glp134","volume":"64A","author":"JB Mason","year":"2009","unstructured":"Mason JB, Cargill SL, Anderson GB, Carey JR. Transplantation of young ovaries to old mice increased life span in transplant recipients. J Gerontol A Biol Sci Med Sci. 2009;64A(12):1207\u201311. https:\/\/doi.org\/10.1093\/gerona\/glp134.","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"3","key":"2019_CR33","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1111\/j.1474-9726.2011.00691.x","volume":"10","author":"JB Mason","year":"2011","unstructured":"Mason JB, Cargill SL, Griffey SM, Reader JR, Anderson GB, Carey JR. Transplantation of young ovaries restored cardioprotective influence in postreproductive-aged mice. Aging Cell. 2011;10(3):448\u201356. https:\/\/doi.org\/10.1111\/j.1474-9726.2011.00691.x.","journal-title":"Aging Cell"},{"issue":"12","key":"2019_CR34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0145821","volume":"10","author":"JB Mason","year":"2015","unstructured":"Mason JB, Terry BC, Merchant SS, Mason HM, Nazokkarmaher M. Manipulation of ovarian function significantly influenced trabecular and cortical bone volume, architecture and density in mice at death. PLoS One. 2015;10(12):e0145821. https:\/\/doi.org\/10.1371\/journal.pone.0145821.","journal-title":"PLoS One"},{"key":"2019_CR35","doi-asserted-by":"publisher","DOI":"10.3791\/56638","volume":"132","author":"JB Mason","year":"2018","unstructured":"Mason JB, Parkinson KC, Habermehl TL. Orthotopic ovarian transplantation procedures to investigate the life- and health-span influence of ovarian senescence in female mice. Journal of Visualized Experiments: JoVE. 2018;132:56638. https:\/\/doi.org\/10.3791\/56638.","journal-title":"Journal of Visualized Experiments: JoVE"},{"issue":"1","key":"2019_CR36","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1146\/annurev.pa.36.040196.001515","volume":"36","author":"PB Hoyer","year":"1996","unstructured":"Hoyer PB, Sipes IG. Assessment of follicle destruction in chemical-induced ovarian toxicity. Annu Rev Pharmacol Toxicol. 1996;36(1):307\u201331. https:\/\/doi.org\/10.1146\/annurev.pa.36.040196.001515.","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"6","key":"2019_CR37","first-page":"523","volume":"55","author":"JC Lohff","year":"2005","unstructured":"Lohff JC, Christian PJ, Marion SL, Arrandale A, Hoyer PB. Characterization of cyclicity and hormonal profile with impending ovarian failure in a novel chemical-induced mouse model of perimenopause. Comp Med. 2005;55(6):523\u20137.","journal-title":"Comp Med"},{"issue":"2","key":"2019_CR38","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1095\/biolreprod.108.070359","volume":"80","author":"Z Rivera","year":"2009","unstructured":"Rivera Z, Christian PJ, Marion SL, Brooks HL, Hoyer PB. Steroidogenic capacity of residual ovarian tissue in 4-vinylcyclohexene diepoxide-treated mice. Biol Reprod. 2009;80(2):328\u201336. https:\/\/doi.org\/10.1095\/biolreprod.108.070359.","journal-title":"Biol Reprod"},{"issue":"10","key":"2019_CR39","doi-asserted-by":"publisher","first-page":"2052","DOI":"10.1071\/RD16333","volume":"29","author":"RL Peterson","year":"2017","unstructured":"Peterson RL, Parkinson KC, Mason JB. Restoration of immune and renal function in aged females by re-establishment of active ovarian function. Reprod Fertil Dev. 2017;29(10):2052\u20139. https:\/\/doi.org\/10.1071\/RD16333.","journal-title":"Reprod Fertil Dev"},{"key":"2019_CR40","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.2147\/JPR.S253069","volume":"13","author":"Q Zhang","year":"2020","unstructured":"Zhang Q, Flach CR, Mendelsohn R, Page L, Whitson S, Boncheva Bettex M. Visualization of epidermal reservoir formation from topical diclofenac gels by Raman spectroscopy. J Pain Res. 2020;13:1621\u20137. https:\/\/doi.org\/10.2147\/JPR.S253069.","journal-title":"J Pain Res"},{"issue":"1","key":"2019_CR41","doi-asserted-by":"publisher","DOI":"10.3402\/pba.v1i0.7189","volume":"1","author":"MA Mahlke","year":"2011","unstructured":"Mahlke MA, Cortez LA, Ortiz MA, Rodriguez M, Uchida K, Shigenaga MK, et al. The anti-tumor effects of calorie restriction are correlated with reduced oxidative stress in ENU-induced gliomas. Pathobiology of Aging & Age Related Diseases. 2011;1(1):7189. https:\/\/doi.org\/10.3402\/pba.v1i0.7189.","journal-title":"Pathobiology of Aging & Age Related Diseases"},{"issue":"4","key":"2019_CR42","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1007\/BF03324169","volume":"5","author":"RT Bronson","year":"1993","unstructured":"Bronson RT, Lipman RD. FRAR course on laboratory approaches to aging. The role of pathology in rodent experimental gerontology. Aging (Milan, Italy). 1993;5(4):253\u20137. https:\/\/doi.org\/10.1007\/BF03324169.","journal-title":"Aging (Milan, Italy)"},{"issue":"5","key":"2019_CR43","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1016\/j.cmet.2018.12.008","volume":"29","author":"M Ogrodnik","year":"2019","unstructured":"Ogrodnik M, Zhu Y, Langhi LGP, Tchkonia T, Kr\u00fcger P, Fielder E, et al. Obesity-induced cellular senescence drives anxiety and impairs neurogenesis. Cell Metab. 2019;29(5):1061-1077.e8. https:\/\/doi.org\/10.1016\/j.cmet.2018.12.008.","journal-title":"Cell Metab"},{"key":"2019_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2020.111425","volume":"194","author":"VA Ansere","year":"2021","unstructured":"Ansere VA, Ali-Mondal S, Sathiaseelan R, Garcia DN, Isola JVV, Henseb JD, et al. Cellular hallmarks of aging emerge in the ovary prior to primordial follicle depletion. Mech Ageing Dev. 2021;194:111425. https:\/\/doi.org\/10.1016\/j.mad.2020.111425.","journal-title":"Mech Ageing Dev"},{"key":"2019_CR45","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2021.111669","author":"JVV Isola","year":"2022","unstructured":"Isola JVV, Zanini BM, Hense JD, Alvarado-Rinc\u00f3n JA, Garcia DN, Pereira GC, et al. Mild calorie restriction, but not 17\u03b1-estradiol, extends ovarian reserve and fertility in female mice. Exp Gerontol. 2022. https:\/\/doi.org\/10.1016\/j.exger.2021.111669.","journal-title":"Exp Gerontol"},{"issue":"5","key":"2019_CR46","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1210\/er.2009-0006","volume":"30","author":"FJ Broekmans","year":"2009","unstructured":"Broekmans FJ, Soules MR, Fauser BC. Ovarian aging: mechanisms and clinical consequences. Endocr Rev. 2009;30(5):465\u201393. https:\/\/doi.org\/10.1210\/er.2009-0006.","journal-title":"Endocr Rev"},{"issue":"1","key":"2019_CR47","doi-asserted-by":"publisher","first-page":"5128","DOI":"10.1038\/s41467-018-07454-w","volume":"9","author":"BC Searle","year":"2018","unstructured":"Searle BC, Pino LK, Egertson JD, Ting YS, Lawrence RT, MacLean BX, et al. Chromatogram libraries improve peptide detection and quantification by data independent acquisition mass spectrometry. Nat Commun. 2018;9(1):5128. https:\/\/doi.org\/10.1038\/s41467-018-07454-w.","journal-title":"Nat Commun"},{"issue":"40","key":"2019_CR48","doi-asserted-by":"publisher","first-page":"25625","DOI":"10.1021\/acsomega.0c02564","volume":"5","author":"S Graw","year":"2020","unstructured":"Graw S, Tang J, Zafar MK, Byrd AK, Bolden C, Peterson EC, et al. ProteiNorm \u2013 a user-friendly tool for normalization and analysis of TMT and label-free protein quantification. ACS Omega. 2020;5(40):25625\u201333. https:\/\/doi.org\/10.1021\/acsomega.0c02564.","journal-title":"ACS Omega"},{"issue":"7","key":"2019_CR49","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007","volume":"43","author":"ME Ritchie","year":"2015","unstructured":"Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W, et al. Limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 2015;43(7):e47. https:\/\/doi.org\/10.1093\/nar\/gkv007.","journal-title":"Nucleic Acids Res"},{"issue":"85","key":"2019_CR50","doi-asserted-by":"publisher","DOI":"10.21105\/joss.05184","volume":"8","author":"TJ Thurman","year":"2023","unstructured":"Thurman TJ, Washam CL, Alkam D, Bird JT, Gies A, Dhusia K, et al. ProteoDA: a package for quantitative proteomics. J Open Source Softw. 2023;8(85):5184. https:\/\/doi.org\/10.21105\/joss.05184.","journal-title":"J Open Source Softw"},{"key":"2019_CR51","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.62199","volume":"9","author":"M Shinohara","year":"2020","unstructured":"Shinohara M, Kanekiyo T, Tachibana M, Kurti A, Shinohara M, Fu Y, et al. APOE2 is associated with longevity independent of Alzheimer\u2019s disease. Elife. 2020;9:e62199. https:\/\/doi.org\/10.7554\/eLife.62199.","journal-title":"Elife"},{"issue":"6","key":"2019_CR52","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.1002\/glia.23974","volume":"69","author":"MF Lanfranco","year":"2021","unstructured":"Lanfranco MF, Sepulveda J, Kopetsky G, Rebeck GW. Expression and secretion of apoE isoforms in astrocytes and microglia during inflammation. Glia. 2021;69(6):1478\u201393. https:\/\/doi.org\/10.1002\/glia.23974.","journal-title":"Glia"},{"issue":"45","key":"2019_CR53","doi-asserted-by":"publisher","first-page":"11445","DOI":"10.1523\/JNEUROSCI.1972-08.2008","volume":"28","author":"DR Riddell","year":"2008","unstructured":"Riddell DR, Zhou H, Atchison K, Warwick HK, Atkinson PJ, Jefferson J, et al. Impact of apolipoprotein E (ApoE) polymorphism on brain ApoE levels. J Neurosci. 2008;28(45):11445\u201353. https:\/\/doi.org\/10.1523\/JNEUROSCI.1972-08.2008.","journal-title":"J Neurosci"},{"issue":"9","key":"2019_CR54","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1016\/j.neurobiolaging.2007.11.014","volume":"30","author":"MP Vitek","year":"2009","unstructured":"Vitek MP, Brown CM, Colton CA. APOE genotype-specific differences in the innate immune response. Neurobiol Aging. 2009;30(9):1350\u201360. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2007.11.014.","journal-title":"Neurobiol Aging"},{"issue":"5","key":"2019_CR55","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/s0197-4580(02)00016-7","volume":"23","author":"CA Colton","year":"2002","unstructured":"Colton CA, Brown CM, Cook D, Needham LK, Xu Q, Czapiga M, et al. APOE and the regulation of microglial nitric oxide production: a link between genetic risk and oxidative stress. Neurobiol Aging. 2002;23(5):777\u201385. https:\/\/doi.org\/10.1016\/s0197-4580(02)00016-7.","journal-title":"Neurobiol Aging"},{"issue":"s185","key":"2019_CR56","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1111\/j.1600-0404.2006.00680.x","volume":"185","author":"DT Laskowitz","year":"2006","unstructured":"Laskowitz DT, Fillit H, Yeung N, Toku K, Vitek MP. Apolipoprotein E-derived peptides reduce CNS inflammation: implications for therapy of neurological disease. Acta Neurol Scand Suppl. 2006;185(s185):15\u201320. https:\/\/doi.org\/10.1111\/j.1600-0404.2006.00680.x.","journal-title":"Acta Neurol Scand Suppl"},{"issue":"11","key":"2019_CR57","doi-asserted-by":"publisher","first-page":"1983","DOI":"10.1089\/neu.2010.1396","volume":"27","author":"DT Laskowitz","year":"2010","unstructured":"Laskowitz DT, Song P, Wang H, Mace B, Sullivan PM, Vitek MP, et al. Traumatic brain injury exacerbates neurodegenerative pathology: improvement with an apolipoprotein E-based therapeutic. J Neurotrauma. 2010;27(11):1983\u201395. https:\/\/doi.org\/10.1089\/neu.2010.1396.","journal-title":"J Neurotrauma"},{"issue":"1","key":"2019_CR58","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.expneurol.2004.11.014","volume":"192","author":"JR Lynch","year":"2005","unstructured":"Lynch JR, Wang H, Mace B, Leinenweber S, Warner DS, Bennett ER, et al. A novel therapeutic derived from apolipoprotein E reduces brain inflammation and improves outcome after closed head injury. Exp Neurol. 2005;192(1):109\u201316. https:\/\/doi.org\/10.1016\/j.expneurol.2004.11.014.","journal-title":"Exp Neurol"},{"issue":"4","key":"2019_CR59","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1002\/glia.20772","volume":"57","author":"A Pocivavsek","year":"2009","unstructured":"Pocivavsek A, Burns MP, Rebeck GW. Low-density lipoprotein receptors regulate microglial inflammation through c-Jun N-terminal kinase. Glia. 2009;57(4):444\u201353. https:\/\/doi.org\/10.1002\/glia.20772.","journal-title":"Glia"},{"issue":"4","key":"2019_CR60","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1007\/s00221-013-3464-x","volume":"226","author":"AC Leuthold","year":"2013","unstructured":"Leuthold AC, Mahan MY, Stanwyck JJ, Georgopoulos A, Georgopoulos AP. The number of cysteine residues per mole in apolipoprotein E affects systematically synchronous neural interactions in women\u2019s healthy brains. Exp Brain Res. 2013;226(4):525\u201336. https:\/\/doi.org\/10.1007\/s00221-013-3464-x.","journal-title":"Exp Brain Res"},{"key":"2019_CR61","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.104795","volume":"138","author":"DA Butterfield","year":"2020","unstructured":"Butterfield DA, Mattson MP. Apolipoprotein E and oxidative stress in brain with relevance to Alzheimer\u2019s disease. Neurobiol Dis. 2020;138:104795. https:\/\/doi.org\/10.1016\/j.nbd.2020.104795.","journal-title":"Neurobiol Dis"},{"issue":"3","key":"2019_CR62","doi-asserted-by":"publisher","first-page":"201","DOI":"10.14283\/jpad.2017.22","volume":"4","author":"Y Hara","year":"2017","unstructured":"Hara Y, McKeehan N, Dacks PA, Fillit HM. Evaluation of the neuroprotective potential of N-acetylcysteine for prevention and treatment of cognitive aging and dementia. J Prev Alzheimers Dis. 2017;4(3):201\u20136. https:\/\/doi.org\/10.14283\/jpad.2017.22.","journal-title":"J Prev Alzheimers Dis"},{"issue":"2","key":"2019_CR63","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1080\/10715760701861373","volume":"42","author":"P Bermejo","year":"2008","unstructured":"Bermejo P, Mart\u00edn-Arag\u00f3n S, Bened\u00ed J, Sus\u00edn C, Felici E, Gil P, et al. Peripheral levels of glutathione and protein oxidation as markers in the development of Alzheimer\u2019s disease from mild cognitive impairment. Free Radic Res. 2008;42(2):162\u201370. https:\/\/doi.org\/10.1080\/10715760701861373.","journal-title":"Free Radic Res"},{"key":"2019_CR64","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.899175","volume":"14","author":"J-H Tong","year":"2022","unstructured":"Tong J-H, Gong S-Q, Zhang Y-S, Dong J-R, Zhong X, Wei M-J, et al. Association of circulating apolipoprotein AI levels in patients with Alzheimer\u2019s disease: a systematic review and meta-analysis. Front Aging Neurosci. 2022;14:899175. https:\/\/doi.org\/10.3389\/fnagi.2022.899175.","journal-title":"Front Aging Neurosci"},{"key":"2019_CR65","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.exger.2017.03.002","volume":"92","author":"KC Parkinson","year":"2017","unstructured":"Parkinson KC, Peterson RL, Mason JB. Cognitive behavior and sensory function were significantly influenced by restoration of active ovarian function in postreproductive mice. Exp Gerontol. 2017;92:28\u201333. https:\/\/doi.org\/10.1016\/j.exger.2017.03.002.","journal-title":"Exp Gerontol"},{"issue":"4","key":"2019_CR66","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1111\/j.1474-9726.2008.00395.x","volume":"7","author":"MD Ganfornina","year":"2008","unstructured":"Ganfornina MD, Do Carmo S, Lora JM, Torres-Schumann S, Vogel M, Allhorn M, et al. Apolipoprotein D is involved in the mechanisms regulating protection from oxidative stress. Aging Cell. 2008;7(4):506\u201315. https:\/\/doi.org\/10.1111\/j.1474-9726.2008.00395.x.","journal-title":"Aging Cell"},{"issue":"4","key":"2019_CR67","doi-asserted-by":"publisher","first-page":"613","DOI":"10.4088\/jcp.v68n0419","volume":"68","author":"KD Coon","year":"2007","unstructured":"Coon KD, Myers AJ, Craig DW, Webster JA, Pearson JV, Lince DH, et al. A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer\u2019s disease. J Clin Psychiatry. 2007;68(4):613\u20138. https:\/\/doi.org\/10.4088\/jcp.v68n0419.","journal-title":"J Clin Psychiatry"},{"issue":"4","key":"2019_CR68","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.ajhg.2009.03.011","volume":"84","author":"JA Webster","year":"2009","unstructured":"Webster JA, Gibbs JR, Clarke J, Ray M, Zhang W, Holmans P, et al. Genetic control of human brain transcript expression in Alzheimer disease. Am J Hum Genet. 2009;84(4):445\u201358. https:\/\/doi.org\/10.1016\/j.ajhg.2009.03.011.","journal-title":"Am J Hum Genet"},{"issue":"5","key":"2019_CR69","doi-asserted-by":"publisher","first-page":"1017.e1","DOI":"10.1016\/j.neurobiolaging.2011.09.033","volume":"33","author":"PL De Jager","year":"2012","unstructured":"De Jager PL, Shulman JM, Chibnik LB, Keenan BT, Raj T, Wilson RS, et al. A genome-wide scan for common variants affecting the rate of age-related cognitive decline. Neurobiol Aging. 2012;33(5):1017.e1-15. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2011.09.033.","journal-title":"Neurobiol Aging"},{"issue":"19","key":"2019_CR70","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1161\/CIRCULATIONAHA.107.693382","volume":"116","author":"M Westerterp","year":"2007","unstructured":"Westerterp M, Berb\u00e9e JFP, Pires NMM, van Mierlo GJD, Kleemann R, Romijn JA, et al. Apolipoprotein C-I is crucially involved in lipopolysaccharide-induced atherosclerosis development in apolipoprotein E-knockout mice. Circulation. 2007;116(19):2173\u201381. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.107.693382.","journal-title":"Circulation"},{"issue":"9","key":"2019_CR71","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlr.2022.100263","volume":"63","author":"J Koska","year":"2022","unstructured":"Koska J, Furtado J, Hu Y, Sinari S, Budoff MJ, Billheimer D, et al. Plasma proteoforms of apolipoproteins C-I and C-II are associated with plasma lipids in the multi-ethnic study of atherosclerosis. J Lipid Res. 2022;63(9):100263. https:\/\/doi.org\/10.1016\/j.jlr.2022.100263.","journal-title":"J Lipid Res"},{"issue":"8","key":"2019_CR72","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1016\/S0022-2275(20)42621-5","volume":"31","author":"KH Weisgraber","year":"1990","unstructured":"Weisgraber KH. Apolipoprotein E distribution among human plasma lipoproteins: role of the cysteine-arginine interchange at residue 112. J Lipid Res. 1990;31(8):1503\u201311.","journal-title":"J Lipid Res"},{"issue":"18","key":"2019_CR73","doi-asserted-by":"publisher","first-page":"10771","DOI":"10.1016\/S0021-9258(18)87014-4","volume":"265","author":"RC Kowal","year":"1990","unstructured":"Kowal RC, Herz J, Weisgraber KH, Mahley RW, Brown MS, Goldstein JL. Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein. J Biol Chem. 1990;265(18):10771\u20139.","journal-title":"J Biol Chem"},{"issue":"1","key":"2019_CR74","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1037\/a0013607","volume":"123","author":"S Pietropaolo","year":"2009","unstructured":"Pietropaolo S, Sun Y, Li R, Brana C, Feldon J, Yee BK. Limited impact of social isolation on Alzheimer-like symptoms in a triple transgenic mouse model. Behav Neurosci. 2009;123(1):181\u201395. https:\/\/doi.org\/10.1037\/a0013607.","journal-title":"Behav Neurosci"},{"key":"2019_CR75","unstructured":"Characterization of the APP\/PS1 mouse model of Alzheimer\u2019s disease. (n.d.). PsychoGenics. Retrieved September 8, 2025, from https:\/\/www.psychogenics.com\/resources\/characterization-of-the-app-ps1-mouse-model-of-alzheimers-disease\/"},{"key":"2019_CR76","doi-asserted-by":"publisher","first-page":"40889","DOI":"10.1038\/srep40889","volume":"7","author":"K Czamara","year":"2017","unstructured":"Czamara K, Majzner K, Selmi A, Baranska M, Ozaki Y, Kaczor A. Unsaturated lipid bodies as a hallmark of inflammation studied by Raman 2D and 3D microscopy. Sci Rep. 2017;7:40889. https:\/\/doi.org\/10.1038\/srep40889.","journal-title":"Sci Rep"},{"issue":"3","key":"2019_CR77","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1111\/acel.12064","volume":"12","author":"V Gonzalez-Covarrubias","year":"2013","unstructured":"Gonzalez-Covarrubias V, Beekman M, Uh H-W, Dane A, Troost J, Paliukhovich I, et al. Lipidomics of familial longevity. Aging Cell. 2013;12(3):426\u201334. https:\/\/doi.org\/10.1111\/acel.12064.","journal-title":"Aging Cell"},{"issue":"10","key":"2019_CR78","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1016\/j.devcel.2021.03.034","volume":"56","author":"AS Mutlu","year":"2021","unstructured":"Mutlu AS, Duffy J, Wang MC. Lipid metabolism and lipid signals in aging and longevity. Dev Cell. 2021;56(10):1394\u2013407. https:\/\/doi.org\/10.1016\/j.devcel.2021.03.034.","journal-title":"Dev Cell"},{"issue":"8","key":"2019_CR79","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70512","volume":"21","author":"A Wretlind","year":"2025","unstructured":"Wretlind A, Xu J, Chen W, Velayudhan L, Ashton NJ, Zetterberg H, et al. Lipid profiling reveals unsaturated lipid reduction in women with Alzheimer\u2019s disease. Alzheimers Dement. 2025;21(8):e70512. https:\/\/doi.org\/10.1002\/alz.70512.","journal-title":"Alzheimers Dement"},{"issue":"5","key":"2019_CR80","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1159\/000358072","volume":"8","author":"B Nicol","year":"2014","unstructured":"Nicol B, Yao HH-C. Building an ovary: insights into establishment of somatic cell lineages in the mouse. Sex Dev. 2014;8(5):243\u201351.","journal-title":"Sex Dev"}],"container-title":["GeroScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11357-025-02019-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11357-025-02019-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11357-025-02019-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:20:42Z","timestamp":1790140842000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11357-025-02019-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,13]]},"references-count":80,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["2019"],"URL":"https:\/\/doi.org\/10.1007\/s11357-025-02019-4","relation":{},"ISSN":["2509-2723"],"issn-type":[{"value":"2509-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,13]]},"assertion":[{"value":"2 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None declared.","order":2,"name":"Ethics","label":"Disclosures","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}