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Glutamate-weighted chemical exchange saturation transfer (gluCEST) MRI provides a non-invasive method for mapping glutamate distribution with high spatial resolution. Collecting data from a large cohort of healthy mice aged 2 to 23\u00a0months, scanned in vivo at 17.2\u00a0T, we demonstrate that gluCEST can differentiate multiple brain regions, and introduce a gluCEST template for the mouse mid-rostrocaudal brain from Bregma\u2009\u22120.5 to\u2009\u22124\u00a0mm approximately. Our findings reveal significant age-related decreases in gluCEST values in the hippocampus, thalamus, and hypothalamus. These decreases did not correlate with volume reductions of these regions, except in the hippocampus, indicating gluCEST as a complementary neuroimaging approach to overall anatomical changes. Our study also demonstrates gluCEST\u2019s potential to monitor age-related changes in smaller brain subregions, such as cortical and hippocampal layers, providing a valuable tool for longitudinal investigations into aging and neurodegenerative diseases. The high spatial resolution and sensitivity offered by ultra-high magnetic field MR scanners enhance the precision of these measurements, paving the way for future preclinical and clinical applications.<\/jats:p>","DOI":"10.1007\/s11357-026-02290-z","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T01:49:33Z","timestamp":1778291373000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["High-resolution glutamate-weighted mapping of in vivo mouse brain across age with chemical exchange saturation transfer MRI"],"prefix":"10.1007","author":[{"given":"R.","family":"Gaudin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Delebarre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Glatigny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Selingue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Debacker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Ciobanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1823-0555","authenticated-orcid":false,"given":"D.","family":"Boido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,9]]},"reference":[{"key":"2290_CR1","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1016\/j.cmet.2018.05.011","volume":"27","author":"MP Mattson","year":"2018","unstructured":"Mattson MP, Arumugam TV. 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